Brain and Behavior最新文献

{"title":"A Meta-Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long-Term Downregulation of Myelin-Related Gene Expression","authors":"Toni Q. Duan, Megan H. Hagenauer, Elizabeth I. Flandreau, Anne Bader, Duy Manh Nguyen, Pamela M. Maras, Randriely Merscher S. De Lima, Trevonn Gyles, Christabel Mclain, Michael J. Meaney, Eric J. Nestler, Stanley J. Watson Jr., Huda Akil","doi":"10.1002/brb3.70608","DOIUrl":"https://doi.org/10.1002/brb3.70608","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Early life stress (ELS) refers to exposure to negative childhood experiences, such as neglect, disaster, and physical, mental, or emotional abuse. ELS can permanently alter the brain, leading to cognitive impairment, increased sensitivity to future stressors, and mental health risks. The prefrontal cortex (PFC) is a key brain region implicated in the effects of ELS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To better understand the effects of ELS on the PFC, we ran a meta-analysis of publicly available transcriptional profiling datasets. We identified five datasets (GSE89692, GSE116416, GSE14720, GSE153043, and GSE124387) that characterized the long-term effects of multiday postnatal ELS paradigms (maternal separation, limited nesting/bedding) in male and female laboratory rodents (rats, mice). The outcome variable was gene expression in the PFC later in adulthood as measured by microarray or RNA-Seq. To conduct the meta-analysis, preprocessed gene expression data were extracted from the Gemma database. Following quality control, the final sample size was <i>n</i> = 89<i>(n</i> = 42 controls and <i>n</i> = 47 ELS: GSE116416, <i>n</i> = 23 (no outliers); GSE116416, <i>n</i> = 44 (two outliers); GSE14720, <i>n</i> = 7 (no outliers); GSE153043, <i>n</i> = 9 (one outlier); and GSE124387, <i>n</i> = 6 (no outliers)). Differential expression was calculated using the <i>limma</i> pipeline followed by an empirical Bayes correction. For each gene, a random-effects meta-analysis model was then fit to the ELS versus control effect sizes (Log2 Fold Changes) from each study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our meta-analysis yielded stable estimates for 11,885 genes, identifying five genes with differential expression following ELS (false discovery rate < 0.05) — transforming growth factor alpha (<i>Tgfa</i>), IQ motif containing GTPase activating protein 3 (<i>Iqgap3</i>), collagen, type XI, alpha 1 (<i>Col11a1</i>), claudin 11 (<i>Cldn11</i>), and myelin-associated glycoprotein (<i>Mag</i>) — all of which were downregulated. Broadly, gene sets associated with oligodendrocyte differentiation, myelination, and brain development were downregulated following ELS. In contrast, genes previously shown to be upregulated in major depressive disorder patients were upregulated following ELS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that ELS during critical periods of development may produce long-term effects on the efficiency of transmission in the PFC and drive changes in gene ex","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70608","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Inflammation and Immune Dysregulation in PTSD","authors":"Luodong Yang,&nbsp;Jiaying Lu,&nbsp;Zhiqiang Zhao,&nbsp;Ziwei Zhang,&nbsp;Weiliang Yang,&nbsp;Guiqing Zhang","doi":"10.1002/brb3.70633","DOIUrl":"https://doi.org/10.1002/brb3.70633","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Post-traumatic stress disorder (PTSD) is a severe psychological condition triggered by traumatic events, commonly characterized by symptoms such as re-experiencing traumatic memories, avoidance, hyperarousal, and disturbances in cognition and emotions. While PTSD is often viewed through a psychological lens, increasing evidence highlights its strong association with immune system dysfunction and inflammation. This narrative review summarizes recent research progress on the role of inflammation and immune dysregulation in PTSD, highlighting key findings and their implications for understanding the pathophysiology of the disorder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a search in the PubMed and Web of Science databases using the keywords “PTSD” and “related inflammatory markers” and discussed the existing literature on the relationship between PTSD and inflammatory responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The research indicates that PTSD is marked by significant imbalances in pro-inflammatory and anti-inflammatory cytokines across various biological fluids, including blood, saliva, and cerebrospinal fluid. Abnormal immune cell activation and elevated levels of soluble adhesion molecules, chemokines, and markers of inflammation were frequently observed in PTSD patients. These inflammatory responses are accompanied by aberrant activity in central immune cells, suggesting that inflammation may play a key role in the pathogenesis of PTSD. In addition, neuroinflammatory processes were linked to cognitive and emotional disturbances commonly seen in individuals with PTSD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings suggest that immune system dysfunction and inflammation are integral components of PTSD pathology. Understanding the mechanisms of neuroinflammation and immune dysregulation could facilitate the early identification of individuals at high risk for PTSD and pave the way for inflammation-targeted therapies. Future research should focus on developing novel anti-inflammatory interventions to complement existing therapeutic approaches, potentially offering new avenues for precision treatment strategies for PTSD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Sleep, Inflammation and Female Infertility: A Cross-Sectional Survey and Genetic Approach","authors":"Xin Xin,&nbsp;Jiaxi Li,&nbsp;Jinfu Zhang,&nbsp;Haicui Wu","doi":"10.1002/brb3.70627","DOIUrl":"https://doi.org/10.1002/brb3.70627","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Inflammation has been implicated in both reproduction and sleep; however, the relationships remain unclear, and conclusive evidence for genetic associations is lacking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study utilized the 2013–2020 National Health and Nutrition Examination Survey (NHANES) data and conducted a Mendelian randomization (MR) analysis to investigate the associations among inflammation, sleep, and female infertility. A cross-sectional study was performed on 370 infertile women aged 20–44 years. Multiple linear regression was applied to evaluate the associations between sleep and the inflammatory markers. Subgroup and interaction analyses were conducted to assess the robustness of the findings. MR analysis was performed on 91 circulating inflammatory proteins, 11 sleep traits, and infertility to examine potential genetic associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 370 infertile participants aged 20–44 years were included. The logarithmic platelet–lymphocyte ratio (PLR) was significantly higher in the sleep disorder group (<i>p</i> &lt; 0.05). After adjusting for potential confounders, sleep disorders remained associated with a reduction in PLR (<i>β</i> = −0.145, 95% CI: −0.267 to −0.023, <i>p</i> &lt; 0.05). MR analysis using the inverse variance weighted (IVW) method indicated that insomnia, subjective long sleep duration, and high sleep efficiency were associated with increased levels of oncostatin-M, artemisinin, and adenosine deaminase, all of which are implicated in infertility. Additionally, the morning type was associated with increased levels of C-X-C motif chemokine 5, which reduced the risk of infertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sleep is associated with various inflammatory factors in the body and may contribute to infertility. Inflammation appears to play a key role in mediating the complex interplay between sleep and reproduction. These findings highlight the potential value of screening and managing specific inflammatory markers in infertile patients with sleep disorders to improve reproductive outcomes. However, further clinical studies and mechanistic experiments are needed to validate the genetic associations identified in this study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Association Between Default Mode Network Connectivity and Attachment Styles in Healthy Individuals and Crohn's Disease Patients","authors":"Alessandro Agostini,&nbsp;Sara Ventura,&nbsp;Silvia Tempia Valenta,&nbsp;Fernando Rizzello,&nbsp;Paolo Gionchetti,&nbsp;Francesca Benuzzi,&nbsp;Nicola Filippini","doi":"10.1002/brb3.70620","DOIUrl":"https://doi.org/10.1002/brb3.70620","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Crohn's disease (CD) is associated with psychological disorders and insecure attachment styles, potentially reflecting the long-lasting disease effect. Although functional magnetic resonance imaging (fMRI) studies revealed differences in CD patients relative to HC, the brain properties underlying the attachment dimensions in CD remain scarcely investigated. We carried out an fMRI study to investigate the neural substrate of the attachment dimensions in CD patients and healthy controls (HCs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Method</h3>\u0000 \u0000 <p>Nineteen CD patients and 18 HC were included in this study. All participants filled out the Attachment Style Questionnaire (ASQ) widely used to evaluate the dimensions of the attachment style and underwent an MRI protocol including structural and functional scans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The ASQ scores were similar between groups. Concerning the resting fMRI data, we identified two opposite trajectories for the association between two ASQ subscales reflecting attachment insecurity and the default mode network (DMN) connectivity between the two study groups. For the HC, higher scores at the ASQ were associated with reduced DMN connectivity, whereas in CD patients were related to increased DMN connectivity. The significant clusters were located in the superior frontal gyrus, posterior cingulate, and orbito-frontal regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>DMN is involved in higher mental functions including self-consciousness and affective processes. In CD patients, the DMN modifications associated with attachment insecurity might reflect dysfunctional monitoring of the self and the significant relationships potentially involved in the development of psychological stress and decreased mentalization. Our study strengthens the notion that the attachment dimensions should be considered in the treatment of IBD and encourages novel psychotherapeutic approaches based on mentalization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"22q11.2 Deletion Syndrome: Cognitive, Visuomotor, and Adaptive Functioning Followed Longitudinally","authors":"L. Wallin,&nbsp;C. Gillberg,&nbsp;J. Knutsson,&nbsp;E. Fernell,&nbsp;I. C. Gillberg,&nbsp;E. Billstedt","doi":"10.1002/brb3.70638","DOIUrl":"https://doi.org/10.1002/brb3.70638","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Longitudinal studies on cognitive, visuomotor, and adaptive function and their relation to outcomes in adults with the 22q11.2 deletion syndrome (22q11.2DS) are limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study involved 79 participants (43 females, 36 males) from an original cohort of 100 individuals (58 females, 42 males) with 22q11.2DS, assessed at ages 1–35 years between 1997 and 2006 (T1) and followed up in 2017–2022 (T2), when they were aged 18–50. Clinical, neuropsychological, and adaptive functioning assessments were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At the group level, overall Full-Scale Intelligence Quotient (FSIQ) remained stable; however, females displayed a significant decline in FSIQ and visuomotor integration (Beery VMI) from T1 to T2. At follow-up, 19 of 56 (34%) participants had an uneven intelligence quotient (IQ) profile, with most (15/56; 27%) showing a higher Verbal Function Index (VFI) than Perceptual Function Index (PFI). At T1, 10 of 49 participants (20%) had this “uneven IQ profile,” defined as having a higher VFI than PFI (Verbal Comprehension Index [VCI] ≥15 IQ points higher than Perceptual Reasoning Index [PRI]), compared to 14 of 49 (29%) at T2. In the psychosis subgroup (<i>n</i> = 8), FSIQ and Verbal Intelligence Quotient (VIQ) showed significant decreases; however, the small sample size limits the validity of these findings. Severe to moderate adaptive function impairments, as measured by the Global Assessment of Functioning (GAF) scale, were observed at T2, with T1 FSIQ predicting GAF at T2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While group-level intellectual functioning appeared stable, individual declines were noted. Long-term follow-up is essential for personalized support to mitigate severe psychiatric risks, including psychosis with declines in FSIQ, particularly VIQ, potentially indicating or resulting from psychosis in this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Effects of Emotional Freedom Techniques on Sexual Dysfunction and Self-Care Management in Women Diagnosed With Multiple Sclerosis","authors":"Ayşe Çuvadar,&nbsp;Ayfer Güneş,&nbsp;Yeter Çuvadar Baş,&nbsp;Sezgin Kehaya","doi":"10.1002/brb3.70635","DOIUrl":"https://doi.org/10.1002/brb3.70635","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to determine the effects of Emotional Freedom Techniques (EFT) on sexual dysfunction and self-care in women diagnosed with multiple sclerosis (MS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This study was conducted using a pretest–posttest experimental design, including follow-up assessments to evaluate the sustainability of the intervention effects. The sample consisted of 16 women aged between 19 and 49 years who were diagnosed with MS and presented to the neurology clinic of a university hospital in Türkiye between October 2023 and September 2024. Data collection instruments included the Personal Information Form (PIF), Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19), and Self-Care Management Process in Chronic Illness (SCMP-G). Repeated measures analysis of variance (ANOVA) was employed to analyze changes in sexuality and self-care over time. Statistical significance was set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants received two EFT sessions per month, each lasting 60 min, together with affirmation sessions conducted at least twice a week for 10–15 min. The mean scores of all subdimensions of the MSISQ-19 reached the lowest levels by the seventh week following EFT intervention, with significant differences between time points (<i>p</i> &lt; 0.05). Even though an improvement was observed in the social protection dimension of self-care, the mean scores for the self-protection subdimension decreased.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The application of EFT demonstrated positive effects on sexual functioning and self-care levels in women with MS. Therefore, EFT can be integrated into the holistic care processes of patients with MS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making Sense of Proprioception by Bibliometric Research","authors":"Kevser Sevik Kacmaz","doi":"10.1002/brb3.70610","DOIUrl":"https://doi.org/10.1002/brb3.70610","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Proprioception is one of the most significant factors in balance, stability, fine movements, coordination, and injury prevention. Proprioception research helps clarify how the nervous system integrates sensory inputs to plan and execute movements. Bibliometric analyses offer a systematic and comprehensive understanding of a field's structure, evolution, trends, research clusters, and gaps, laying a scientific foundation for future research. This study employs bibliometric analysis to provide a panoramic view of proprioception research and to identify its thematic structure, evolution, production, and impact.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 4506 original studies from 1979 to 2024 were extracted from the WoS. Using the Bibliometrix application in RStudio, a bibliometric analysis examined scientific performance, production, citation impact, research trends, developments, and the conceptual framework related to proprioception research. The Biblioshiny application performed the scientific mapping.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Proprioception research has increased linearly. The most influential article was Sensorimotor System Measurement Techniques, published in the Journal of Athletic Training, with 455 citations. Uwe Proske was the most influential author, with an &lt;i&gt;h&lt;/i&gt;-index of 20 in proprioception. The literature utilized 6797 keywords. Of these, 29% was proprioception, 4% joint position sense, and 4% rehabilitation. Keyword trends showed a shift toward rehabilitation and neurophysiology, with terms such as “rehabilitation,” “balance,” and “stroke” becoming more prevalent. However, an emerging interest in psychophysics, which investigates the interaction between proprioception and sensory perception, is also evident. This theme offers significant opportunities for future research. The USA leads in productivity, contributing 57.70% of the total publications, followed by Canada with 19.32%, and the UK with 18.28%.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The results indicate a significant upward trend in research output, highlighting the increasing importance of proprioception in clinical and research settings. The findings emphasize several gaps in current proprioception research, including the need for greater interdisciplinary collaboration, particularly with neuroprosthetics and AI-driven proprioceptive modeling. Furthermore, geographical diversity in research, particularly from underrepresented regions, is critical for comprehensively understanding propri","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70610","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory Processing Difficulties in Children With Eosinophilic Esophagitis","authors":"Muserrefe Nur Keles,&nbsp;Hacer Ilbilge Ertoy Karagol,&nbsp;Ramazan Yildiz,&nbsp;Odul Egritas Gurkan,&nbsp;Sinan Sari,&nbsp;Bulent Elbasan,&nbsp;Buket Dalgic,&nbsp;Arzu Bakirtas,&nbsp;Gazi University Pediatric Eosinophilic Gastrointestinal Diseases Working Group","doi":"10.1002/brb3.70642","DOIUrl":"https://doi.org/10.1002/brb3.70642","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease associated with dysphagia, food impaction, feeding difficulties, vomiting, and failure to thrive in children. These symptoms result from dysregulated neural control and inflammation-induced tissue remodeling and may extend beyond esophageal dysfunction to impact sensory processing. This study aimed to evaluate the sensory processing difficulties in children with EoE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective case-control study included children with EoE and age-matched healthy controls. Sociodemographic data and medical histories were collected. Sensory processing abilities were evaluated using the sensory profile, which evaluates sensory performance across multiple domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 69 children aged 3–10 years participated in the study, including 22 diagnosed with EoE and 47 healthy controls. No significant demographic differences were found between groups (<i>p</i> &gt; 0.05). Children with EoE exhibited significantly greater sensory processing difficulties in oral sensory processing, vestibular processing, and oral sensory sensitivity compared to healthy controls (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Sensory processing difficulties in children with EoE extend beyond feeding challenges, affecting oral sensory and vestibular processing functions. Incorporating sensory processing assessments into clinical evaluations may improve the understanding of sensory-related challenges in this population. A multidisciplinary approach could help refine clinical management strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Marathon Enthusiast Engagement Through AI: A Quantitative Study on the Role of Social Media in Sports Communication","authors":"Wei Cheng,&nbsp;Yu Tian,&nbsp;Meng Na","doi":"10.1002/brb3.70593","DOIUrl":"https://doi.org/10.1002/brb3.70593","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study explores the impact of AI-driven personalization, interactive features, and real-time feedback on user engagement and experience among marathon enthusiasts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>By integrating uses and gratifications theory (UGT), self-determination theory (SDT), and the technology acceptance model (TAM), the research examines how these AI-driven elements influence user behavior on marathon-related social media platforms. A quantitative approach using partial least squares structural equation modeling (PLS-SEM) was applied to data from 400 Chinese marathon enthusiasts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>The findings reveal that AI-driven personalized content significantly enhances user engagement and experience, with user engagement partially mediating this relationship. Interactive features are crucial for building a sense of community but have a less direct impact on user experience. Real-time feedback significantly improves user engagement, particularly for users with higher technological proficiency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This research contributes to the understanding of user engagement in AI-enhanced environments and provides practical insights for designing more personalized and interactive platforms for marathon enthusiasts. Future studies should explore the long-term effects, cultural factors, and ethical considerations of AI-driven personalization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Large-Scale Brain Network Abnormalities in Patients With Beta-Thalassemia","authors":"Mingrui Yang,&nbsp;Guowei Chen,&nbsp;Peng Peng,&nbsp;Cheng Tang,&nbsp;Chaotian Luo,&nbsp;Fei Peng,&nbsp;Rong Kong,&nbsp;Chunxia Zhu,&nbsp;Jiatong Liang","doi":"10.1002/brb3.70614","DOIUrl":"https://doi.org/10.1002/brb3.70614","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Beta-thalassemia major (β-TM) is a hereditary blood disorder characterized by chronic anemia and hypoxia, which may have profound effects on brain function. This study systematically evaluates alterations in both intra-brain network functional connectivity (FC) and inter-network functional connectivity (FNC) in β-TM patients using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), aiming to uncover the potential mechanisms underlying their neurofunctional impairments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 72 β-TM patients and 50 age- and gender-matched healthy controls (HC). rs-fMRI was used to collect brain functional data, and ICA was applied to extract 14 resting-state functional networks (RSNs). Differences in FC within networks and FNC between the two groups were further compared to investigate the brain network abnormalities in β-TM patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In β-TM patients, FC within brain networks was significantly reduced in the anterior default mode network (aDMN), posterior default mode network (pDMN), left frontoparietal network (lFPN), right frontoparietal network (rFPN), ventral attention network (VAN), and executive control network (ECN). In contrast, FC was significantly increased in the dorsal sensorimotor network (dSMN) and posterior visual network (pVN). FNC analysis revealed that β-TM patients exhibited enhanced connectivity between the lFPN and rFPN, as well as between the dorsal attention network (DAN) and VAN. However, connectivity was significantly weakened between the DAN and lFPN, ECN, auditory network (AN), and salience network (SN); as well as between the pVN and dSMN. These findings suggest impairments in cognitive control, attention allocation, and sensory integration, with specific disruptions in the SN that may contribute to the observed dysfunctions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Brain network abnormalities in β-TM patients manifest as an alternating pattern of enhanced and weakened connectivity, revealing the profound impact of chronic anemia and hypoxia on cognitive, emotional, and sensory functions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}