Brain and Behavior最新文献

{"title":"Corrigendum to “Optimal Timing of Exercise for Enhanced Learning and Memory: Insights from CA1 and CA3 Regions in Traumatic Brain Injury Model in Male Rats”","authors":"","doi":"10.1002/brb3.71795","DOIUrl":"10.1002/brb3.71795","url":null,"abstract":"<p>F. Rafie, S. Amiresmaili, M. A. Rajizadeh, M. Pourranjbar, E. Jafari, M. Khaksari, S. Shirazpour, O. Moradnejad and A. H. Nekouei, Brain and Behavior 15, no. 3 (2025): e70354, https://doi.org/10.1002/brb3.70354.</p><p>The originally published article contained two errors that require correction.</p><p>First, the sample size reported in the captions of Figures 1, 3, 4, 5, 6G, 7G, and 8 was incorrectly stated as n = 7 or n = 8 due to a typographical error. The correct sample size is n = 6 per group throughout, consistent with the Methods section and with the degrees of freedom reported in all statistical analyses (F (5,30)). The figure captions have been corrected accordingly to reflect n = 6 per group.</p><p>Second, an error occurred during the preparation of Figure 6. The representative micrograph in Panel B (NE group, CA1 region, H&amp;E ×400) has been corrected. This correction does not affect the histological scoring, statistical analyses, or the conclusions of the study.</p><p>Corrected Figure 6:</p><p></p><p>The authors apologize for these errors.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.71795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Predictors of Depressive Symptom Trajectories in Older Adults: A Systematic Review","authors":"Yuying Li,&nbsp;Qiuyan Liu,&nbsp;Xue Dong","doi":"10.1002/brb3.71793","DOIUrl":"10.1002/brb3.71793","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To describe the distribution patterns and cross-study heterogeneity of depressive symptom trajectories in older adults and to identify consistent predictors of high-symptom trajectories for targeted intervention strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA 2020 guidelines, six databases were searched from April 2010 to January 2026 for longitudinal studies using latent variable mixture models in adults aged ≥ 60 years. Study quality was assessed using the Newcastle–Ottawa Scale. Descriptive synthesis was employed due to methodological heterogeneity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-one studies (median <i>N</i> = 3428; 26 observations after accounting for within-study stratification by sex, poverty status, and country) met inclusion criteria. High-symptom trajectories were identified in 18 of 21 studies (0%–42.2%). Low-symptom trajectories predominated (12.4%–84.5%). Consistent risk factors included female sex, functional limitations, and multimorbidity. Higher educational attainment was the most consistent protective factor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Older adults exhibit heterogeneous depressive symptom trajectories, with clinically significant high-symptom subgroups universally present but context-dependent. Modifiable predictors provide evidence for precision prevention strategies. Because estimates are descriptive and derived from heterogeneous instruments, they should be interpreted as heuristic indicative ranges rather than precise global benchmarks. Standardized assessment protocols are needed to enable quantitative synthesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizability Affects the Processing of Facial Gender Information","authors":"Szabolcs Sáringer,&nbsp;András Benyhe,&nbsp;Péter Kaposvári","doi":"10.1002/brb3.71826","DOIUrl":"10.1002/brb3.71826","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The different aspects of a face, like sex, gender, or identity, can be decoded from the cortical patterns related to its processing. Many studies have investigated this phenomenon with similar outcomes. These studies usually utilize a low number of facial identities and high repetition numbers, potentially affecting the recognizability of a face, thus altering the processing. We propose that this commonly employed paradigm influences cortical patterns associated with features seemingly unrelated to identity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>In the first experiment, we adapted common paradigm parameters from previous studies using a few identities and a high presentation number for decoding facial gender. In the second experiment, the identity-presentation ratio was switched.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>This change resulted in a narrower time window where facial gender related cortical patterns were detected. Decoding accuracy was also diminished, yielding lower values and suggesting a reduced signal-to-noise ratio in the cortex. After expanding the sample size to balance male and female participants, we identified shared cortical patterns related to facial gender processing both within the population and across gender-based subpopulations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results provide further evidence that exposure time to a singular face affects its processing and suggest that previous findings on perceived gender information decoding were likely influenced by the experimental paradigms employed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Persian Version of the Mind Excessively Wandering Scale in Iranian Adolescents: A Validation Study","authors":"Mina Hasanpour,&nbsp;Kousar Dadkhah Tehrani,&nbsp;Amir Sam Kianimoghadam,&nbsp;Yalda Daneshi Hir,&nbsp;Abolfazl Chekaneh Bajestani,&nbsp;Shima Hasanpour,&nbsp;Maryam Maadi Esfahan","doi":"10.1002/brb3.71824","DOIUrl":"10.1002/brb3.71824","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The Mind Excessively Wandering Scale (MEWS) assesses excessive mind-wandering. This study evaluated the psychometric properties of the Persian 12-item MEWS (MEWS-12) among Iranian adolescents, focusing on factor structure, internal consistency, associations with external measures, known-groups validity, and gender measurement invariance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>In this cross-sectional study, 506 adolescents aged 12–18 years completed the MEWS and measures of rumination, attentional control, mindfulness, depressive and anxiety symptoms, and positive and negative affect. All 15 original MEWS items were administered, with the developer-recommended 12-item version designated for primary analyses. The sample was randomly divided, with stratification by gender, into independent exploratory factor analysis (EFA; <i>n</i> = 254) and confirmatory factor analysis (CFA; <i>n</i> = 252) subsamples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Finding</h3>\u0000 \u0000 <p>Parallel analysis favored a two-factor EFA solution accounting for 54% of the variance, with a factor correlation of 0.73. In CFA, the correlated two-factor model showed better fit than the unidimensional model, <i>χ</i>²(53) = 122.89, CFI = 0.971, TLI = 0.964, RMSEA = 0.072, 90% CI [0.056, 0.089], and SRMR = 0.054, although the factors were highly correlated (<i>r</i> = 0.858). Internal consistency was good (<i>α</i> = 0.893; <i>ω</i> = 0.917). Higher MEWS-12 scores were associated with greater depressive and anxiety symptoms, rumination, and negative affect, and with lower mindfulness and positive affect; the association with self-reported attentional control was small and non-significant. Adolescents at or above the selected GAD-7 and PHQ-9 symptom thresholds had higher MEWS-12 scores than those below the respective thresholds. Gender invariance analyses provided preliminary support for comparable measurement properties across girls and boys.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings provide preliminary evidence regarding the psychometric properties of the Persian MEWS-12 among Iranian adolescents. The two-factor representation should be interpreted cautiously given the substantial factor overlap. Further replication in independent samples and evaluation in longitudinal and clinically characterized studies are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke","authors":"Yu Cui,&nbsp;Zi-Ang Li,&nbsp;Chao He,&nbsp;Hui-Sheng Chen","doi":"10.1002/brb3.71813","DOIUrl":"10.1002/brb3.71813","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dual antiplatelet therapy (DAPT) was noninferior to alteplase in nondisabling minor stroke (NIHSS 0 to 5). Given potential benefit of DAPT in minor stroke with large artery atherosclerosis (LAA) and of alteplase in stroke with NIHSS 4–5, we hypothesize that neurological deficit and LAA may affect efficacy of DAPT versus alteplase in minor stroke.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This analysis included patients from the ARAMIS trial with minor stroke who underwent vessel imaging assessment. Participants were stratified into NIHSS 0–3 with LAA, NIHSS 0–3 with Non-LAA, NIHSS 4–5 with LAA, and NIHSS 4–5 with Non-LAA. Outcomes were compared between those receiving DAPT versus alteplase. Primary outcome was an excellent functional outcome (mRS 0 to 1) at 90 days. Safety outcomes included symptomatic intracranial hemorrhage and bleeding events. Primary analysis employed adjusted models, with sensitivity analysis conducted using inverse probability of treatment weighting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 478 included patients, including 388 in NIHSS 0–3 group and 90 in NIHSS 4–5 group. In NIHSS 0–3 group, a numerically higher rates of excellent functional outcome was found in patients with LAA who received DAPT versus alteplase (97.3% vs. 85.1%; adjusted OR, 6.45 [0.68 to 60.81]; <i>p</i> = 0.10), which was obviously attenuated in patients with Non-LAA (96.5% vs. 94.4%; adjusted OR, 1.67 [0.50 to 5.59]; <i>p</i> = 0.41). This phenomenon was not observed in NIHSS 4–5 group, and the test for interaction was not statistically significant (<i>p</i>-interaction = 0.36). Notably, sensitivity analysis revealed that DAPT significantly increased the likelihood of excellent functional outcome in the NIHSS 0–3 with LAA subgroup (adjusted OR, 6.49 [1.54 to 27.39]; <i>p</i> = 0.01), but not in NIHSS 0–3 with Non-LAA subgroup (adjusted OR, 2.51 [0.58 to 10.90]; <i>p</i> = 0.22). Safety outcomes were comparable across treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Neurological deficit and LAA may affect efficacy of DAPT versus alteplase in acute minor nondisabling stroke. In patients with NIHSS scores of 0 to 3 due to LAA, DAPT may be associated with numerically higher odds of 90-day functional outcomes compared to alteplase. Given the exploratory nature of this subgroup analysis and no formal adjustment for multiple comparisons was applied, these results should be interpreted as hypothesis-generating and require confirmation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Flow Restriction Training in Stroke Rehabilitation: A Narrative Review of Current Evidence and Future Directions.","authors":"Jiawei Tong, Lei Song, Juan Jin, Fangfang Li, Tao Huang, Hang Ying, Jiawei Zhu, Jue Wang, Jie Zhuang","doi":"10.1002/brb3.71832","DOIUrl":"10.1002/brb3.71832","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke motor deficits cause disability, while paresis and comorbidities may limit high-intensity training. Blood flow restriction training (BFRT) combines low-intensity exercise with partial vascular occlusion and may promote neuromuscular adaptations at low loads.</p><p><strong>Methods: </strong>This narrative review synthesized peer-reviewed evidence on BFRT in stroke rehabilitation. Stroke-specific clinical studies, particularly randomized controlled trials (RCTs), were prioritized for evaluating clinical effects; experimental, preclinical, physiological, mechanistic, review, and guideline evidence provided context. RCT data included participant characteristics, protocols, outcomes, and adverse events. Two reviewers independently assessed risk of bias using the Cochrane Risk of Bias tool (RoB 1). Findings were synthesized qualitatively without meta-analysis or GRADE assessment.</p><p><strong>Results: </strong>Sixty-seven reports were included, comprising eight stroke-specific clinical studies and 59 contextual reports. Participants represented early, subacute, and chronic stroke stages, although stroke stage and baseline impairment were inconsistently reported. Studies generally enrolled medically stable individuals with adequate motor control, postural stability, or walking capacity; those with severe paresis or substantial mobility dependence were underrepresented. Improvements were reported in strength, motor function, balance, walking, mobility, activities of daily living, muscle morphology, and cortical activation. However, between-group benefits were inconsistent, and BFRT was not consistently superior to conventional, unrestricted, or high-intensity resistance exercise. No serious BFRT-related adverse events were reported, but safety reporting was incomplete.</p><p><strong>Conclusion: </strong>BFRT may be a useful low-load adjunct for selected stroke survivors, particularly in lower-limb rehabilitation. Evidence remains preliminary because of risk of bias, small samples, heterogeneous protocols, short follow-up, and limited representation of severely impaired patients. Well-controlled studies are needed before broad implementation.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":"e71832"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ensemble-Based Machine Learning Models for Classifying Intervention-Related Psychological Outcome Patterns in Menopausal Women Treated With Pimpinella anisum.","authors":"Md Belal Bin Heyat, Arshiya Sultana, Attiq Ur Rehman, Arfa Begum, Mohamad Sawan","doi":"10.1002/brb3.71787","DOIUrl":"10.1002/brb3.71787","url":null,"abstract":"<p><strong>Background: </strong>Menopause, a natural biological transition in the life of women, is often associated with significant psychological disturbances such as depression, anxiety, and stress. However, early identification and management of psychological disorders in menopausal women remain under-addressed due to limited specialist access and a lack of systematic screening approaches.</p><p><strong>Purpose: </strong>This study aimed to develop ensemble-based machine learning (ML) models to classify intervention-related clinical and psychological outcome patterns in menopausal women using clinical and questionnaire-based data collected during a controlled intervention study.</p><p><strong>Method: </strong>Psychological and menopausal symptoms were assessed using standardized tools, including the Depression Anxiety Stress Scale-21 (DASS-21), modified Kupperman index (MKI), vaginal health index (VHI), and menopause symptoms treatment satisfaction questionnaire (MS-TSQ). Statistical analyzes were performed using chi-square tests and independent t-tests to evaluate group differences. Three ensemble classifiers, random forest (RF), gradient boosting (GB), and AdaBoost (AB), were evaluated using repeated cross-validation.</p><p><strong>Result: </strong>Among these, the RF classifier achieved the best performance with a sensitivity of 93.3%, a specificity of 90.0%, an accuracy of 91.7%, a precision of 90.3%, and an F1-score of 91.8%.</p><p><strong>Conclusion: </strong>These results indicate that ensemble ML models, particularly RF, can serve as effective supplementary tools for psychological disorder risk stratification in menopausal care, aiding clinicians in decision-making. However, these models are intended to complement, not replace, clinical assessments.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":"e71787"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRS-Assessed Resilience, Symptom Burden, and Functional Burden in Adolescents With Depressive, Anxiety, or Somatic Symptom-Related Disorders: A Single-Center Real-World Cross-Sectional Study.","authors":"Longhuan Zhang, Meiying Zhang, Xuejing Liu, Lingcong Wu, Yang Zhang, Jing Shan","doi":"10.1002/brb3.71811","DOIUrl":"10.1002/brb3.71811","url":null,"abstract":"<p><strong>Background: </strong>Adolescents with depressive, anxiety, and somatic symptom-related disorders often present with overlapping symptom domains and functional difficulties, but cross-sectional associations of Brief Resilience Scale (BRS) score with multidimensional symptom and functional burden in routine outpatient care remain insufficiently characterized.</p><p><strong>Methods: </strong>This single-center, real-world, cross-sectional study retrospectively analyzed routinely collected data from adolescents aged 12-18 years attending a psychological/psychiatric outpatient clinic between January 2024 and December 2025. Eligible patients had clinician-recorded depressive, anxiety, or somatic symptom-related disorders and completed the BRS, PHQ-9, GAD-7, and PHQ-15. Associations of BRS score with symptom outcomes and predefined pragmatic functional-burden indicators were assessed using multivariable linear, logistic, and negative binomial regression models; restricted cubic spline analyses were exploratory.</p><p><strong>Results: </strong>Among 522 screened adolescents, 447 were included. Across increasing BRS-score quartiles, mean PHQ-9 scores ranged from 17.1 ± 5.8 to 9.9 ± 5.2, GAD-7 scores from 13.4 ± 5.1 to 7.2 ± 4.5, and PHQ-15 scores from 12.2 ± 5.0 to 6.9 ± 4.3. The predefined marked functional impairment indicator ranged from 71.4% in Q1 to 30.6% in Q4 (P for trend <0.001). After adjustment, each 1-SD higher BRS score was associated with lower PHQ-9 score (β, -2.42; 95% CI, -3.02 to -1.82), GAD-7 score (β, -1.84; 95% CI, -2.38 to -1.30), PHQ-15 score (β, -1.50; 95% CI, -2.05 to -0.95), and functional impairment count (incidence rate ratio, 0.72; 95% CI, 0.64 to 0.82). Higher BRS score was also associated with lower odds of PHQ-9 score ≥10 (OR, 0.49; 95% CI, 0.36 to 0.66), GAD-7 score ≥10 (OR, 0.57; 95% CI, 0.43 to 0.75), PHQ-15 score ≥10 (OR, 0.61; 95% CI, 0.45 to 0.82), and marked functional impairment (OR, 0.53; 95% CI, 0.40 to 0.71). Exploratory spline analyses showed graded inverse associations but were not interpreted as identifying clinical thresholds.</p><p><strong>Conclusion: </strong>Higher BRS score was concurrently associated with lower depressive, anxiety, and somatic symptom burden and fewer pragmatic indicators of functional burden in adolescent psychiatric outpatients. These cross-sectional findings do not establish causality, prognostic utility, or treatment-guiding value; longitudinal studies are needed to clarify temporal relationships and clinical utility.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":"e71811"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Hematoma Evacuation for Acute Spontaneous Supratentorial Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis With Trial Sequential Analysis.","authors":"Sahar Saleem, Zaryab Bacha, Khushal Khan, Khawaja Arham Jawaid, Muhammad Abbas, Shahab Iqbal, Umer Zaryab Khan, Muhammad Waqas, Saja Mohammed Taher Al-Zamili, Humaira Obaid, Zuha Kashif, Abdullah Abdullah, Zahra Rehman, Javeria Javed, Kamil Ahmad Kamil","doi":"10.1002/brb3.71815","DOIUrl":"10.1002/brb3.71815","url":null,"abstract":"<p><strong>Background: </strong>Intracerebral hemorrhage (ICH) is a severe form of stroke associated with high morbidity and mortality. While surgical evacuation aims to reduce hematoma burden and improve outcomes, its clinical benefit over medical management remains uncertain. Previous systematic reviews have evaluated a broad range of surgical interventions for ICH; however, evidence specific to MIS remains less clearly defined. Therefore, we performed a systematic review and meta-analysis to assess the efficacy and safety of minimally invasive hematoma evacuation in patients with acute spontaneous supratentorial ICH.</p><p><strong>Methods: </strong>This meta-analysis was performed in accordance with PRISMA 2020 guidelines and Cochrane recommendations. A comprehensive search of MEDLINE, Embase, Cochrane CENTRAL, and ClinicalTrials.gov was conducted from inception to February 2026. We included randomized controlled trials that compared minimally invasive hematoma evacuation with medical or conventional surgical management. Risk ratios (RR) and mean differences (MD) were pooled using a random-effects model.</p><p><strong>Results: </strong>A total of 12 RCTs involving over 2302 patients were included. Minimally invasive hematoma evacuation significantly reduced all-cause mortality (RR = 0.77, 95% CI 0.61-0.97; p = 0.02) and 6-month mortality (RR = 0.79, 95% CI 0.64-0.96; p = 0.02). No significant differences were observed in 7-day or 30-day mortality, although a trend favoring the intervention was noted. Functional outcomes, including mRS 0-1 and mRS 0-3, did not improve significantly. Among secondary outcomes, minimally invasive approaches were associated with greater hematoma volume reduction (MD = 62.47; p = 0.04) but also a higher risk of rebleeding (RR = 2.37; p = 0.002) and cardiac events (RR = 5.08; p = 0.009). No significant differences were found in ischemic stroke, renal failure, gastrointestinal bleeding, seizures, urinary tract infections, or length of hospital and ICU stay.</p><p><strong>Conclusions: </strong>Minimally invasive hematoma evacuation significantly decreases mortality in patients with spontaneous ICH, especially with endoscopic techniques; however, it does not markedly enhance functional outcomes and may elevate the risk of complications such as rebleeding and cardiac events. These results underscore the necessity for meticulous patient selection and additional high-caliber trials to enhance treatment strategies.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":"e71815"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic Use and Self-Reported Psychological, Cognitive, and Gastrointestinal Outcomes in a Community Sample: A Cross-Sectional Observational Study.","authors":"Kim Marie Gehrke, Eef Hogervorst, Thomas D W Wilcockson","doi":"10.1002/brb3.71834","DOIUrl":"10.1002/brb3.71834","url":null,"abstract":"<p><strong>Background: </strong>Research on probiotics and health outcomes has produced mixed findings. While the gut-brain axis provides a theoretical framework for probiotics to influence psychological and cognitive health, evidence remains inconsistent, particularly in community samples. This study examined associations between probiotic use and psychological, cognitive, and gastrointestinal outcomes, with particular attention to delivery method (supplement vs. fermented food).</p><p><strong>Methods: </strong>One hundred and fifty adults (M = 25.82, SD = 10.99) completed validated measures of depressive and anxiety symptoms, stress resilience, gastrointestinal complaints, cognitive lapses, hazardous drinking, and disordered eating. Group differences were examined using Kruskal-Wallis tests (unadjusted) and two covariate-adjusted ANCOVA models (Model 1: age, gender, and physical activity; Model 2: additionally adjusting for prebiotic use and dietary adherence).</p><p><strong>Results: </strong>In unadjusted analyses, probiotic supplement users reported lower depressive and anxiety symptoms, fewer gastrointestinal complaints, and reduced cognitive lapses than non-probiotic users. After adjustment, gastrointestinal symptoms remained significantly associated with probiotic use across both models (p = 0.034, Model 1; p = 0.017, Model 2). Anxiety symptoms and cognitive lapses were significantly associated with probiotic use in Model 1 (p = 0.026 and p = 0.018, respectively) but attenuated to non-significance in the fully adjusted model. Stress resilience was non-significant in Model 1 but reached significance in Model 2 (p = 0.035). However, none of these associations survived Bonferroni correction for multiple comparisons across the five primary outcomes (α = 0.01). Fermented food users did not differ from other groups on any outcomes.</p><p><strong>Conclusions: </strong>In this community sample, unadjusted analyses suggested probiotic supplement use was associated with lower depressive symptoms, anxiety symptoms, gastrointestinal symptoms, and cognitive lapses. After adjustment, gastrointestinal symptoms showed the most consistent association, while anxiety symptoms, cognitive lapses, and stress resilience showed inconsistent, model-dependent associations. No associations were robust to correction, and all findings should be interpreted as preliminary. Longitudinal and experimental research with larger samples is needed to establish causality and clarify the conditions under which probiotic use may confer health benefits.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 10","pages":"e71834"},"PeriodicalIF":2.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}