Brain and Behavior最新文献

{"title":"Association of Sarcopenia With Cognitive Function in Patients With Parkinson's Disease: A Cross-Sectional Study.","authors":"Qiuwan Liu, Kangrui Zhang, Yi Tang, Chi Zhang, Chengjie Mao, Chunfeng Liu, Juncang Wu","doi":"10.1002/brb3.71460","DOIUrl":"10.1002/brb3.71460","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between sarcopenia and cognitive function in Chinese patients with Parkinson's disease (PD).</p><p><strong>Patients and methods: </strong>This cross-sectional study included 148 patients with PD aged 60 years or older. Sarcopenia, nutritional status, and cognitive functioning were assessed using the 2019 Asian sarcopenia guidelines, the Mini Nutritional Assessment (MNA) scale, and the Montreal Cognitive Assessment (MoCA) scale, respectively. The relationship between sarcopenia and cognitive functioning was examined using multivariable logistic regression, receiver operating characteristic (ROC) analysis, and threshold effect analysis to identify the inflection point. Additionally, mediation analysis was performed to examine potential mediating variables. Subgroup analyses were also conducted to assess the robustness of the results across different populations.</p><p><strong>Results: </strong>In the fully adjusted model, higher MoCA scores were significantly associated with lower odds of sarcopenia (OR = 0.78, 95% CI: 0.69-0.88, p = 0.0001), whereas higher Hamilton Anxiety Inventory (HAMA) scores (OR = 1.11, 95% CI: 1.02-1.21, p = 0.0133) and Hamilton Depression Inventory (HAMD) scores (OR = 1.16, 95% CI: 1.06-1.27, p = 0.0011) were significantly associated with higher odds of sarcopenia. This association was more pronounced in older participants and those with higher HAMA scores. In addition, the multivariable model adjusted for age, gender, BMI, and MoCA showed better discriminative ability for sarcopenia than MoCA alone (AUC: 0.828 vs. 0.778). E-value analysis suggested that the observed association was relatively robust to potential unmeasured confounding.</p><p><strong>Conclusion: </strong>Lower MoCA scores were independently associated with higher odds of sarcopenia in patients with PD. This association was more pronounced in older participants and those with higher anxiety scores. These findings suggest that cognitive assessment may help identify PD patients at increased likelihood of sarcopenia.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71460"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FGF23 and Immune Cell Signatures Causally Linked to Subarachnoid Hemorrhage: Evidence From Multi-Omics and Genetic Colocalization.","authors":"Xingjie Shi, Cheng Zhang, Tao Yang, Zhiming Sun, Chao Wang, Lucheng Zhou, Shiqiang Hou, Ning Lin, Lanlan Zhang","doi":"10.1002/brb3.71485","DOIUrl":"10.1002/brb3.71485","url":null,"abstract":"<p><strong>Background: </strong>Inflammation and immune response significantly contribute to brain injury following subarachnoid hemorrhage (SAH), a severe neurological condition. This study employed Mendelian randomization, colocalization, and multi-omics analysis to examine potential causal connections between inflammatory proteins, immune cells, and SAH, aiming to elucidate its pathogenesis.</p><p><strong>Methods: </strong>This study utilized publicly available data from genome-wide association studies (GWAS), including protein QTL (pQTL) and RNA sequencing data. Bidirectional two-sample Mendelian Randomization (MR) analysis was initially employed to evaluate the cause-and-effect relationships among inflammatory proteins, immune cells, and SAH. A comprehensive multi-omics approach, encompassing transcriptome, colocalization, mediation MR, was employed to identify specific inflammatory proteins, immune cells, and potential drug targets.</p><p><strong>Results: </strong>A causal relationship between five inflammatory proteins and SAH was identified through MR analysis (CD6, FGF23, TGFB-1, LIFR, and TGF-α). Moreover, a causal relationship with SAH was identified in 22 types of immune cells. Subsequent multi-omics analysis showed that FGF23 was a hub inflammatory protein, and its expression level was closely linked to the amount of CD4 Treg cells. Meta-analysis and replication studies identified FGF23 as a risk factor for SAH, with a colocalization score of 0.74.</p><p><strong>Conclusion: </strong>This study successfully identified inflammatory proteins and immune cells associated with SAH, and revealed the complex genetic causality and drug targets of SAH.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71485"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of BWM-T Versus Brief Mindfulness Induction on Stress, Anxiety and Self-Efficacy in University Students: Immediate and Short-Term Outcomes of RCT on Psychological Well-Being and Autonomic Balance.","authors":"Mauro Cozzolino, Marco Borgese, Giovanna Celia","doi":"10.1002/brb3.71471","DOIUrl":"10.1002/brb3.71471","url":null,"abstract":"<p><strong>Background: </strong>University students face increasing levels of stress, anxiety, and self-efficacy, which may disrupt autonomic balance. While many mind-body interventions require sustained practice, growing evidence suggests that even a single session can yield immediate benefits. This randomized controlled trial compared the immediate and short-term effects of the brain wave modulation technique (BWM-T) and a brief mindfulness induction on psychological and physiological outcomes in university students.</p><p><strong>Methods: </strong>68 students were randomly assigned to either BWM-T or a brief mindfulness induction. State anxiety (STAI-Y1), psychological distress (distress thermometer), generalized self-efficacy scale (GSES), and 5 min heart rate variability (HRV) indices were assessed at baseline (T0), immediately after the session (T1), and 4 h later (T2). Mixed-design ANOVAs with Time (T0, T1, T2) as a within-subject factor and group (BWM-T vs. brief mindfulness induction) as a between-subject factor were conducted, followed by paired-sample t-tests where appropriate.</p><p><strong>Results: </strong>Across the total sample, significant main effects of Time emerged for state anxiety, distress, and self-efficacy (ps < 0.001), indicating reductions in anxiety and distress and increases in self-efficacy from pre-to post-session that were largely maintained at the 4 h follow-up. No significant time × group interactions were found for psychological outcomes, suggesting comparable trajectories for BWM-T and mindfulness. For HRV indices, a significant time × group interaction was observed only for VLF power. VLF decreased from T0-T1 in the BWM-T group, whereas no systematic changes were detected in the mindfulness group. All other HRV parameters (SDNN, rMSSD, pNN50, LF, HF, LF/HF) remained stable over time, with no differential group effects.</p><p><strong>Conclusions: </strong>A single 16 min session of either BWM-T or a brief mindfulness induction yielded rapid improvements in self-reported anxiety, distress and GSES in university students, with effects persisting up to 4 h. Physiological effects were limited to a short-lived reduction in VLF power following BWM-T, while other indices of vagally mediated HRV did not change significantly. These findings support the use of brief mind-body practices as feasible tools for acute stress regulation in academic settings, while underscoring the need for larger, adequately powered trials and more comprehensive autonomic assessments.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71471"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Abdominal Acupuncture in Poststroke Constipation: A Systematic Review and Meta-Analysis With Trial Sequential Analysis.","authors":"Wulam Rukye, Hongzhi Yang, Yingjia Li, Xin Li, Nenggui Xu, Zhennan Wu","doi":"10.1002/brb3.71442","DOIUrl":"10.1002/brb3.71442","url":null,"abstract":"<p><strong>Background: </strong>Poststroke constipation (PSC) is a prevalent and disabling condition that significantly affects patient quality of life. Although abdominal acupuncture (AA) has demonstrated potential therapeutic effects on PSC, its efficacy remains unclear. This meta-analysis evaluated the efficacy of manual AA (MAA) and abdominal electroacupuncture (AEA) combined with conventional therapy (CT) for PSC.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted to identify randomized controlled trials comparing the effects of MAA + CT or AEA + CT versus CT alone in PSC treatment. Twelve eligible studies (n = 943) were selected. Primary (efficacy and time to first bowel movement [BM]) and secondary (stool shape) outcomes were evaluated. Trial sequential analysis (TSA) was performed to assess cumulative evidence reliability.</p><p><strong>Results: </strong>Both MAA + CT (relative risk [RR] = 1.26, 95% confidence interval [CI]: 1.13-1.40) and AEA + CT (RR = 1.28, 95% CI: 1.19-1.38) significantly improved efficacy compared with CT alone. Furthermore, MAA + CT (mean difference [MD] = -0.61, 95% CI: -1.02 to -0.19) and AEA + CT (MD = -0.32, 95% CI: -1.09 to -0.46) reduced the time to first BM, albeit evidence regarding stool shape was inconclusive due to significant heterogeneity. TSA demonstrated unclear cumulative evidence and thus could not determine AA efficacy compared with CT.</p><p><strong>Conclusion: </strong>MAA + CT and AEA + CT may effectively improve PSC by enhancing efficacy and shortening the time to first BM. Given the limited number of studies, small sample sizes, and significant heterogeneity, further high-quality trials are required to confirm these findings and optimize the acupuncture regimen for PSC treatment.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71442"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery.","authors":"Mustafa T Ardah, Pareshkumar N Patel, Omayma Salim Waleed, Jamuna K V, Vandana Tripathi, L Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra","doi":"10.1002/brb3.71466","DOIUrl":"10.1002/brb3.71466","url":null,"abstract":"<p><strong>Purpose: </strong>Aging is a progressive biological process characterized by the decline of cellular and tissue homeostasis, increasing vulnerability to chronic diseases, especially neurodegeneration. This review examines the role of microRNAs (miRNAs) in brain aging by linking them to the updated hallmarks of aging and key neurobiological processes.</p><p><strong>Method: </strong>This is an integrative literature review of studies on brain aging, neurodegeneration, and miRNA-mediated regulation. Evidence was synthesized from transcriptomic analyses, experimental studies, and research on circulating systemic factors, including extracellular vesicle-associated miRNAs and plasma proteins. The review focuses on miRNA involvement in genomic stability, nutrient sensing, proteostasis, autophagy, mitochondrial function, telomere maintenance, epigenetic regulation, and cellular senescence.</p><p><strong>Finding: </strong>miRNAs regulate multiple aging-related pathways, including DNA repair, IGF-1/AKT/mTOR signaling, proteostasis, autophagy, and mitochondrial homeostasis. In aging brains, transcriptomic data consistently show reduced expression of genes involved in synaptic plasticity, metabolism, and maintenance, alongside increased inflammatory and immune signaling. Circulating systemic factors and extracellular vesicle miRNAs also influence brain aging, affecting neuroplasticity, cognitive function, and regenerative capacity. These mechanisms contribute to neuroinflammation, synaptic dysfunction, myelin impairment, and neurovascular unit disruption.</p><p><strong>Conclusion: </strong>miRNAs are key regulators of brain aging and neurodegeneration and hold promise as biomarkers and therapeutic targets. However, clinical application is limited by disease heterogeneity, context-dependent effects, off-target activity, and challenges in central nervous system delivery. Further research is needed to support safe and effective miRNA-based interventions.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71466"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Physical Activity and Domain-Specific Cognitive Function in the Elderly: A Cross-Sectional Study and Genetic Analysis.","authors":"Xingxiao Yin, Hao Peng, Yanqi Li, Yanping Song, Longjiang Chen, Na Yao, Pengcheng Li, Zhijuan He, Hongbo Chen, Li Huang, Zhen Shen, Qigang Chen","doi":"10.1002/brb3.71423","DOIUrl":"10.1002/brb3.71423","url":null,"abstract":"<p><strong>Background: </strong>Population aging is intensifying worldwide, increasing the prevalence of dementia. More than 50 million people globally are affected by dementia. There is some evidence that physical activity (PA) benefits cognitive function (CF). However, it is unclear which types and amounts of PA are best for specific cognitive domains.</p><p><strong>Methods: </strong>This study used a cross-sectional design and genetic analysis to test its hypotheses. Participants were drawn from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, including 2578 adults aged 60 years or older. Cognitive abilities were measured using standardized tests, and PA levels were assessed with the Global Physical Activity Questionnaire (GPAQ). The analysis included multivariable regression, threshold effect testing, and subgroup analysis to explore links between PA patterns, intensities, and specific CF domains. Furthermore, a Mendelian randomization (MR) approach was employed to assess whether PA intensity exerts an effect on CF.</p><p><strong>Results: </strong>NHANES data analysis showed that the regular activity (RA) pattern was positively associated with the Consortium to Establish a Registry for Alzheimer's Disease Word Learning test (CERAD-WL) scores (β = 0.07; 95% confidence interval [CI]: 0.02, 0.16; p = 0.018), Animal Fluency Test (AFT) scores (β = 0.31; 95% CI: 0.21, 0.41; p = 0.002), Digit Symbol Substitution Test (DSST) scores (β = 0.19; 95% CI: 0.09, 0.30; p = 0.017), and overall CF (β = 0.23; 95% CI: 0.14, 0.32; p < 0.004). Threshold-effect analysis revealed an inverted U-shaped relationship between PA levels and cognitive performance. The inflection points occurred at 650, 535, and 550 min per week for AFT, DSST, and overall CF, respectively. Above these values, further cognitive gains plateaued. The inverse-variance weighted (IVW) method of the MR analyses showed that moderate-intensity physical activity (MPA) increased correct counting (odds ratio [OR] = 0.710; 95% CI: 0.606, 0.832; p < 0.001), fluid intelligence (OR = 0.470; 95% CI: 0.346, 0.638; p < 0.001), and overall cognitive performance (OR = 0.707; 95% CI: 0.653, 0.764; p < 0.001). For vigorous-intensity physical activity (VPA), we observed causal associations with memory outcomes, reaction time, correct matches, fluid intelligence, and cognitive performance.</p><p><strong>Conclusion: </strong>The findings suggest that PA is associated with multiple domains of CF, and the RA pattern is linked to better cognitive performance. Genetically, VPA appears to have a stronger promotive effect. Thus, different patterns and intensities of PA may help delay cognitive decline and maintain brain health in older adults.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71423"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating Role of Psychological Flexibility in the Relationship Between Intolerance of Uncertainty and Perceived Stress Among Women Undergoing in Vitro Fertilization Treatment.","authors":"Fatemeh Karimzadeh, Abbas Abdollahi, Soolmaz Dehghanidowlatabadi","doi":"10.1002/brb3.71436","DOIUrl":"10.1002/brb3.71436","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to examine the moderating role of psychological flexibility (PF) in the relationship between intolerance of uncertainty (IU) and perceived stress (PS) among women undergoing in vitro fertilization (IVF) treatment.</p><p><strong>Methods: </strong>This study used purposive sampling and included 204 participants. The measurement instruments were the Intolerance of Ambiguity Scale (IUS-12) developed by Carleton and colleagues (2007) for assessing IU, the Perceived Stress Scale (PSS-10) developed by Cohen and colleagues (1983) for evaluating PS, and the Multidimensional Psychological Flexibility Inventory (MPFI-60) developed by Rolffs and colleagues (2018) for assessing PF. A covariance-based structural equation modeling using AMOS (version 24) software to test the direct relationships and multi-group analysis was conducted to assess moderation effects of PF.</p><p><strong>Finding: </strong>The findings indicated that IU and Psychological Inflexibility (PI) positively predicted PS (β = 0.16, p < 0.001), while PF negatively predicted it (β = -0.14, p < 0.001). Multi-group analysis revealed that in the low PF group, the association between IU and PS was significant, positive, and greater (β = 0.28, p < 0.001) than in the high PF group (β = 0.06, p = 0.13).</p><p><strong>Conclusion: </strong>Both variables, namely IU and PI, contribute to increased PS; however, PF moderates this relationship, indicating a protective role of PF in reducing PS among women undergoing IVF treatment.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71436"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Hypotension Following Spinal Manipulation: A Case Report and Scoping Review of the Literature.","authors":"Marina Romozzi, Matteo Palermo, Fabio Zeoli, Federico Tosto, Catello Vollono, Giuseppe Garignano, Francesco Signorelli","doi":"10.1002/brb3.71409","DOIUrl":"https://doi.org/10.1002/brb3.71409","url":null,"abstract":"<p><strong>Purpose: </strong>Spinal manipulative therapies, including chiropractic and osteopathic maneuvers, are widely practiced for musculoskeletal complaints. However, rare but serious complications such as cerebrospinal fluid (CSF) leak with subsequent intracranial hypotension (IH) have been described. The pathophysiological mechanism is presumed to involve mechanical stress on the spinal dura during high-velocity movements, leading to dural tears, particularly in the cervicothoracic region.</p><p><strong>Methods: </strong>We conducted a scoping review in accordance with the PRISMA extension for Scoping Reviews (PRISMA-ScR) guidelines, through a comprehensive search of PubMed and Scopus. We complemented the review with an illustrative case from our institution.</p><p><strong>Results: </strong>We identified 21 eligible studies, including 21 patients with IH following spinal manipulation. Most patients were women (81%), aged 29-54 years, and the majority underwent cervical maneuvers. Symptom onset was typically within the first week, and all presented with orthostatic headache, often accompanied by nausea, neck pain, tinnitus, or visual disturbances. Neuroimaging consistently revealed features of IH, with pachymeningeal enhancement and subdural collections as the most frequent findings; spinal imaging frequently demonstrated extradural CSF collections. Management was conservative in about one-third of cases, but most required epidural blood patching, which was effective in the majority. Surgical repair was necessary in rare, refractory cases, particularly in the presence of structural spinal abnormalities. Overall prognosis was favorable, with 95% of patients achieving full recovery. Our illustrative case highlights the potential for severe complications such as subdural hematomas and recurrence if the underlying leak is not addressed.</p><p><strong>Conclusion: </strong>Clinicians should recognize the possibility of CSF leaks after spinal manipulation, especially in patients with new-onset orthostatic headache.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71409"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-Brain Fractional Anisotropy, Centered on the Superior Longitudinal Fasciculus, Is Positively Correlated With Urban Aesthetic Perception.","authors":"Keisuke Kokubun, Kiyotaka Nemoto, Maya Okamoto, Yoshinori Yamakawa","doi":"10.1002/brb3.71446","DOIUrl":"https://doi.org/10.1002/brb3.71446","url":null,"abstract":"<p><strong>Introduction: </strong>With the growth of the global urban population, interest in urban aesthetics has been steadily increasing. Previous studies using functional magnetic resonance imaging (fMRI) to examine brain responses have suggested that various brain regions may be involved in the perception of urban aesthetics. However, the relationship between brain structure and urban aesthetics remains largely unexplored.</p><p><strong>Methods: </strong>In this study, we hypothesized that fractional anisotropy (FA) in the whole brain and in the superior longitudinal fasciculus (SLF), reflecting large-scale structural connectivity across brain regions, would be associated with subjective evaluations of urban aesthetics. To test this hypothesis, we conducted diffusion tensor imaging (DTI) using magnetic resonance imaging (MRI) in a sample of 82 healthy adults recruited in Japan.</p><p><strong>Results: </strong>The results showed that both whole-brain FA and SLF FA were positively correlated with the Aesthetic Quality Scale, which reflects urban aesthetics.</p><p><strong>Conclusion: </strong>This study is the first to demonstrate that urban aesthetics may be associated with white matter microstructure.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71446"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and Validity of the Chinese Version of the Premenstrual Symptoms Screening Tool.","authors":"Xue Li, Xiaochun Wang","doi":"10.1002/brb3.71455","DOIUrl":"https://doi.org/10.1002/brb3.71455","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the reliability and validity of the Chinese version of the Premenstrual Symptoms Screening Tool (PSST) in a sample of Chinese female college students.</p><p><strong>Methods: </strong>A total of 1366 female college students completed the Chinese version of the PSST, the Patient Health Questionnaire (PHQ), and the Generalized Anxiety Disorder Scale (GAD). According to the screening criteria of the PSST, 196 participants were categorized into the premenstrual syndrome (PMS) group, 24 participants were categorized into the premenstrual dysphoric disorder (PMDD) group, and the remaining 1146 were assigned to the healthy control group. For test-retest reliability assessment, a separate sample of 50 female college students completed the Chinese PSST twice, with a retest interval of 28-32 days (M = 30.27, SD = 0.55).</p><p><strong>Results: </strong>The Cronbach's α coefficients for the Symptom Dimension, Impact Dimension, and total scale of the Chinese PSST were 0.95, 0.93, and 0.91, respectively; the corresponding test-retest reliability coefficients (intraclass correlation coefficient [ICC]) were 0.89, 0.99, and 0.94, respectively. The scale showed satisfactory empirical validity: the proportion of moderate-to-severe symptom endorsements (score = 2-3) across all PSST items was significantly higher in the PMS group and the PMDD group than in the healthy control group (all p < 0.001). Scores on the total PSST and its two dimensions were significantly positively correlated with scores on the PHQ and GAD (all p < 0.001). For construct validity, confirmatory factor analysis (CFA) showed that the Chinese PSST had a two-factor structure (Symptom Dimension and Impact Dimension) with acceptable model fit indices (χ²/df = 4.21, GFI = 0.932, CFI = 0.925, TLI = 0.905, RMSEA = 0.05), indicating good construct validity.</p><p><strong>Conclusion: </strong>The Chinese version of the PSST exhibits excellent reliability and validity among Chinese female college students and thus serves as a reliable tool for screening moderate-to-severe PMS in this population.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 5","pages":"e71455"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}