Brain and Behavior最新文献

{"title":"Analysis of the Maturation of the Median Nerve in Preterm-Born Children During the First 3 Years of Life Using High-Resolution Nerve Ultrasound Imaging","authors":"Lynn Jansen,&nbsp;Noé Bürke,&nbsp;Erin West,&nbsp;Janina Wurster,&nbsp;Philip J. Broser","doi":"10.1002/brb3.70954","DOIUrl":"10.1002/brb3.70954","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the development of the peripheral nervous systems of preterm- and term-born children from birth to 3 years of age by imaging the median nerve.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Measuring the cross-sectional area (CSA) of the median nerve at three locations along the arm in term-born (control group) and preterm-born children (study group) using high-resolution ultrasound imaging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The data revealed a steady myelination that follows a logarithmic curve when considering the increase of the CSA of the median nerve relative to body surface area (BSA) in preterm-born children. Therefore, while the CSA of the median nerve was smaller in premature babies at the time of birth, the maturation of the nerve is comparable for preterm- and term-born children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>This study analyzed how the peripheral nervous system of preterm children develops compared to full-term children and found no differences in terms of median nerve development. Further, these findings align with previous research documenting a logarithmic increase in the CSA of the median nerve with age in full-term infants. This research could be helpful for enabling the use of high-resolution ultrasound imaging as a diagnostic tool for the peripheral nervous system of premature infants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Eye as a Window to Brain Health: Can Retinal Imaging and AI Modeling Predict Alzheimer's Disease?","authors":"Eniola Awodiya","doi":"10.1002/brb3.70890","DOIUrl":"10.1002/brb3.70890","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This is a review article to evaluate clinical evidence for the vascular model of Alzheimer's disease (AD) pathology and elucidate the extent to which retinal imaging with AI modeling can be useful in earlier diagnosis of the condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>I comprehensively reviewed the literature on the current understanding of AD pathology and emerging role of the neurovascular system. I reviewed the evidence for retinal vascular biomarkers that can predict the presence of cognitive impairments seen in AD and AI models that utilize these to diagnose and elucidate pathophysiology for the condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>It is found that retinal imaging offers a non-invasive and cost-effective way to detect AD-related neurovascular changes and, when coupled with AI, holds a transformative role in improving screening, diagnostics, and our understanding of the disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is evidence to suggest that retinal imaging can provide an earlier diagnosis of the condition. This can change the practice by encouraging lifestyle modification as crucial in modifying the progression of the disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Brain Functional Connectivity and Its Correlation With Cognitive Dysfunction in Chronic Kidney Disease Patients via Resting-State fMRI.","authors":"Ying Liu, Yingying Wang, Liling Peng, Huan Yu, Ning Wu, Chunhua Song, Chaoyang Zhang, Yan Cai, Zhenwei Wang, Yiqing Sun, Xin Gao","doi":"10.1002/brb3.70947","DOIUrl":"https://doi.org/10.1002/brb3.70947","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the brain functional connectivity and its association with cognitive function in patients with chronic kidney disease (CKD) using resting-state functional magnetic resonance imaging (rs-fMRI).</p><p><strong>Methods: </strong>A total of 64 CKD patients were enrolled and divided into two groups based on their dependence on dialysis: dialysis-dependent CKD (DD-CKD) group (n = 38) and non-dialysis-dependent CKD (NDD-CKD) group (n = 26). A total of 43 healthy controls (NC) were also recruited and matched for age and sex. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). MRI scans were conducted on a 3.0T Magnetom Skyra scanner equipped with a 32-channel phased array head coil. Data analysis was performed using the Data Processing Assistant for Resting-State fMRI (DPARSF) and Statistical Parametric Mapping (SPM) software.</p><p><strong>Results: </strong>Cognitive scores (MMSE and MoCA) were significantly lower in both CKD groups compared to healthy controls (p < 0.001), with DD-CKD patients exhibiting worse cognitive performance than NDD-CKD patients (p < 0.05). Laboratory parameters also differed: compared with DD-CKD, NDD-CKD patients had significantly lower levels of protein, creatinine, calcium, and phosphate (all p < 0.05). Network-based statistical analysis revealed reduced functional connectivity in both CKD groups relative to controls (p < 0.05). NDD-CKD patients showed disruptions mainly in the frontal-insular and occipital networks, whereas DD-CKD patients exhibited more extensive alterations involving frontoparietal, cingulate, and visual regions. Correlation analysis further showed that connectivity reductions in key regions-including the dorsolateral prefrontal cortex and parietal association areas-were negatively associated with renal function indicators such as serum creatinine and urea nitrogen (p < 0.05).</p><p><strong>Conclusion: </strong>Resting-state fMRI effectively reflects alterations in brain functional connectivity in CKD patients and is associated with cognitive performance. Notably, DD-CKD patients showed more extensive network disruptions and more severe cognitive impairment.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70947"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Preinfection Health Status on COVID-19 Severity and Cognitive Function.","authors":"Kang Yuan, Wenbiao Xian, Lishan Lin, Fengjuan Su, Feiwen Huang, Wenli Sheng, Wanling Wu","doi":"10.1002/brb3.70793","DOIUrl":"10.1002/brb3.70793","url":null,"abstract":"<p><strong>Background: </strong>This observational cohort study investigates how infection health factors influence COVID-19 severity and cognitive outcomes. We collected preinfection data from hospitalized COVID-19 patients, including demographic information and baseline health conditions prior to diagnosis, and examined their associations with hospitalization duration and cognitive function assessed after infection.</p><p><strong>Methods: </strong>Data were obtained from Hui Ya Hospital, The First Affiliated Hospital, Sun Yat-sen University, China. The study included confirmed COVID-19 patients requiring hospitalization. Among the 147 collected cases, two were excluded due to missing data, leaving a final sample of 145 patients. The Montreal Cognitive Assessment (MoCA), which evaluates global cognitive function with a total score of 0-30, was used to assess cognitive function, while hospitalization duration and routine clinical examinations were analyzed as indicators of disease severity. Additionally, the SF-12v2 score reflecting Health-Related Quality of Life was used to evaluate patients' overall health status. Statistical analyses were conducted to identify preinfection factors associated with COVID-19 outcomes.</p><p><strong>Results: </strong>Preinfection baseline health status was significantly correlated with both hospitalization duration (p < 0.0001, 95% CI [-0.47, -0.16]) and MoCA scores (p = 0.0001, 95% CI [0.15, 0.46]). Patients with better preinfection health conditions experienced shorter hospital stays and demonstrated better cognitive function postinfection.</p><p><strong>Conclusion: </strong>Our findings indicate that preinfection baseline health conditions play a crucial role in determining both the severity of COVID-19 and postinfection cognitive function. Specifically, impairments were more pronounced in the visuospatial, naming, attention, calculation, language, and memory domains. Additionally, our results suggest a potential link between COVID-19 outcomes and patients' preexisting underlying diseases.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70793"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Childhood Maltreatment on Affect Labeling in Youth: An ERP Study.","authors":"Yuanyuan Li, Pengfei Yue, Mengmeng Shi","doi":"10.1002/brb3.70929","DOIUrl":"10.1002/brb3.70929","url":null,"abstract":"<p><strong>Background: </strong>Previous studies on emotional processing in individuals with a history of childhood maltreatment have primarily examined either implicit or explicit processing modes in isolation, with limited research integrating both approaches. Empirical evidence regarding the use of affect labeling to regulate emotions among young adults with childhood maltreatment remains lacking. The affect labeling paradigm used in this study incorporates both implicit and explicit processing mechanisms, thereby offering a comprehensive means to investigate how childhood maltreatment specifically influences emotional processing.</p><p><strong>Method: </strong>This study employed event-related potential (ERP) techniques to examine the influence of maltreatment on the affect labeling effect, using both affect labeling and gender labeling tasks. Participants were classified into maltreated (n = 17) and non-maltreated (n = 19) groups based on their scores on the Childhood Trauma Questionnaire-Short Form (CTQ-SF).</p><p><strong>Results: </strong>(1) At Cz and CPz, the LPP amplitudes induced by affect labeling were significantly smaller than those induced by gender labeling. (2) At Fz, FCz, Cz, CPz, and Pz, maltreated individuals exhibited significantly lower LPP amplitudes compared to non-maltreated individuals. (3) With respect to emotional categories, the LPP amplitudes in response to happy faces were smaller than those to angry faces.</p><p><strong>Conclusion: </strong>The findings suggest that implicit emotion regulation is beneficial for young adults with a history of childhood maltreatment in terms of emotion management. Maltreated individuals demonstrated decreased emotional arousal across both implicit and explicit emotional tasks, confirming the influence of maltreatment on the affect labeling effect. This supports the disruption theory. The present study expands the application of the affect labeling effect and provides new electrophysiological evidence for research on cognitive changes in individuals with childhood maltreatment.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70929"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-Induced Gut Dysbiosis Modulates Alzheimer's Disease-Associated Gene Expression and Protein Aggregation in 3xTg-AD Mice via the Gut-Brain Axis.","authors":"Edward Jenner Tettevi, David Larbi Simpong, Mahmoud Maina, Samuel Adjei, Elias Asuming-Brempong, Mike Y Osei-Atweneboana, Augustine Ocloo","doi":"10.1002/brb3.70946","DOIUrl":"https://doi.org/10.1002/brb3.70946","url":null,"abstract":"<p><strong>Introduction: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that poses a major global health challenge due to its increasing prevalence and lack of effective treatments. Emerging evidence suggests the gut-brain axis may play a pivotal role in AD pathogenesis. However, causal links between dysbiosis and late-stage AD pathology remain unclear.</p><p><strong>Methods: </strong>This study evaluated the effects of antibiotic-induced gut dysbiosis in aged 3xTg-AD mice (46-48 weeks). Female mice were randomly assigned to control or treatment groups and administered a broad-spectrum antibiotic cocktail (ampicillin, vancomycin, and neomycin) for 14 days. Behavioral tests (Y-maze, elevated plus maze) were performed to assess cognitive and anxiety-like behaviors. Gut microbiota composition was assessed via 16S rRNA qPCR. Gene expression of Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and Tumor Necrosis Factor-Alpha (TNF-α) was analyzed via qRT-PCR, and cerebral amyloid-β_1-42 and tau protein levels were quantified by ELISA.</p><p><strong>Results: </strong>Antibiotic treatment induced significant dysbiosis, with > 90% reduction in Firmicutes and Bacteroidetes. Dysbiotic mice displayed impaired spatial working memory, heightened anxiety-like behavior, and reduced locomotor activity. Molecular analyses revealed region-specific dysregulation of cholinergic genes: AChE was upregulated in the hippocampus but downregulated in the cortex, while BChE showed the opposite trend. TNF-α was significantly elevated in both regions, indicating neuroinflammation. Dysbiosis also led to increased brain levels of amyloid-β_1-42 and tau.</p><p><strong>Conclusion: </strong>Gut microbiome disruption exacerbates late-stage AD pathology, driving cognitive deficits, neuroinflammation, and hallmark protein aggregation. These findings support the gut-brain axis as a critical modulator of AD and highlight the microbiome as a potential therapeutic target.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70946"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study.","authors":"Wenting Lin, Xiaoqin Chen, Yuxing Wei, Lu Yang, Hui Li, Tianmin Zhu","doi":"10.1002/brb3.70870","DOIUrl":"10.1002/brb3.70870","url":null,"abstract":"<p><strong>Background: </strong>Dysfunction of brain resting-state functional networks has been widely reported in sleep disorders, but their causal relationships remain controversial.</p><p><strong>Objective: </strong>To investigate causal relationships between 191 resting-state functional magnetic resonance imaging (rsfMRI) phenotypes and eight sleep disorders using bidirectional two-sample Mendelian randomization (MR), with multivariable MR (MVMR) adjusting for addictive behaviors.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) data from UK Biobank and FinnGen were analyzed. Instrumental variables (IVs) were selected adhering to MR assumptions. Causal estimates were primarily derived via inverse-variance weighted (IVW), with sensitivity analyses using MR-Egger, weighted median, weighted mode, simple mode, and MR Pleiotropy Residual Sum and Outlier (MR-PRESSO).</p><p><strong>Results: </strong>We found increased functional connectivity within the salience and default mode networks in insular, cingulate, and frontal regions​​ (OR = 0.94, 95% CI: 0.92-0.97, pFDR = 0.042) was causally associated with a 6% reduced risk of daytime napping. For obstructive sleep apnea (OSA), ​​elevated functional connectivity within the default mode and central executive networks localized to precuneus/occipital regions​​ (OR = 1.16, 95% CI: 1.08-1.25, pFDR = 0.042) and ​​elevated functional connectivity within the default mode and central executive networks localized to parietal/temporal regions​​ (OR = 1.18, 95% CI: 1.09-1.27, pFDR = 0.016) having a causal effect, associated with a 16% and 18% elevated risk of OSA respectively. MVMR analysis revealed that coffee intake did not confound associations between rsfMRI phenotypes and sleep disorders, while smoking, alcohol consumption, tea intake, and cannabis use may act as confounding factors affecting these links.</p><p><strong>Conclusion: </strong>This study provides robust evidence for causal associations between specific rsfMRI phenotype signatures and sleep disorders. It highlights brain functional networks as potential targets for non-invasive interventions, particularly within the context of addictive behaviors.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70870"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Sleep Habits and Associated Lifestyle Factors in Adolescents: A Population-Based Study.","authors":"Claire Chenwen Zhong, Mingtao Chen, Zhaojun Li, Zehuan Yang, Vera M W Keung, Amelia Lo, Calvin Cheung, Junjie Huang, Martin C S Wong","doi":"10.1002/brb3.70885","DOIUrl":"https://doi.org/10.1002/brb3.70885","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to examine the associations between adolescent characteristics and sleep habits in Hong Kong.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among secondary school students in Hong Kong. Data on sociodemographics, health behaviors, mental toughness, and sleep patterns were collected. Univariable and multivariable logistic regression analyses were used to identify factors associated with late bedtime, insufficient sleep duration, and late wake-up time.</p><p><strong>Results: </strong>Among 1345 adolescents surveyed, 60.1% reported late bedtime, 56.6% experienced insufficient sleep duration (<8 h), and 34.1% reported late wake-up time. In multivariable models, older age was consistently associated with adverse sleep habits (aOR_{late wake-up} = 1.64, 95% CI: 1.23-2.18, p = 0.001; aOR_{late bedtime} = 2.69, 95% CI: 1.98-3.64, p < 0.001; aOR_{insufficient duration} = 1.74, 95% CI: 1.31-2.31, p < 0.001). Exceeding recommended screen time was linked to later bedtimes (aOR_video = 1.46, 95% CI: 1.14-1.88, p = 0.003; aOR_game = 1.42, 95% CI: 1.10-1.84, p = 0.007; aOR_{social media} = 1.78, 95% CI: 1.38-2.29, p < 0.001) and insufficient sleep duration (aOR_{social media} = 1.87, 95% CI: 1.46-2.39, p < 0.001). Daily breakfast consumption was consistently associated with lower odds of late bedtime (aOR = 0.49, 95% CI: 0.39-0.63, p < 0.001), insufficient sleep duration (aOR = 0.56, 95% CI: 0.44-0.71, p < 0.001), and late wake-up time (aOR = 0.69, 95% CI: 0.54-0.88, p = 0.002). Alcohol consumption was associated with higher odds of insufficient sleep duration (aOR = 1.80, 95% CI: 1.10-2.96, p = 0.020) and lower odds of late wake-up (aOR = 0.60, 95% CI: 0.37-0.96, p = 0.032). Male students had lower odds of insufficient sleep (aOR = 0.69, 95% CI: 0.54-0.87, p = 0.002) but higher odds of waking up late (aOR = 1.75, 95% CI: 1.37-2.24, p < 0.001).</p><p><strong>Conclusion: </strong>This study identified high rates of adverse sleep habits among Hong Kong adolescents and demonstrated strong associations with age, screen use, dietary behavior, and other lifestyle factors. These findings highlight the need for targeted interventions-such as digital use guidelines and school-based breakfast programs-to promote healthy sleep patterns during adolescence.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70885"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid Plaque Characteristics Combined With Serum Inflammatory Biomarkers Predict Recurrent Ischemic Stroke.","authors":"Lin Wang, Tong Chen, Chun Yuan, Thomas Hatsukami, Xihai Zhao, Mi Shen, Peiyi Gao, Xingquan Zhao, Binbin Sui","doi":"10.1002/brb3.70909","DOIUrl":"10.1002/brb3.70909","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the potential value of serum inflammatory markers combined with carotid plaque characteristics for predicting subsequent recurrent ischemic events.</p><p><strong>Methods: </strong>Patients with cerebral infarction localized to the internal carotid artery territory were recruited. Carotid MRI examinations were performed, and the plaque characteristics were evaluated at baseline. Serum samples were obtained, and clinical characteristics were documented at baseline. All participants received clinical follow-up 1 year after discharge. Recurrent ipsilateral ischemic stroke was considered the clinical endpoint. Logistic regression analyses were employed to assess the correlations between serum inflammatory biomarkers, plaque characteristics, and the endpoint. The diagnostic performances were evaluated using receiver operating characteristic curves. DeLong's test was used to compare the areas under the curve (AUCs) of the models.</p><p><strong>Results: </strong>In total, 89 patients (84.3% men; mean age, 56.57 ± 9.05 years) with recent anterior circulation (carotid territory) cerebral hemisphere ischemia were included. Sixteen patients presented with an endpoint within the 1-year follow-up. Multivariate logistic regression demonstrated that the normalized wall index, intraplaque hemorrhage, lipid-rich necrotic core, and high-sensitivity C-reactive protein (Hs-CRP) were associated with the endpoint. The model combining plaque characteristics and Hs-CRP had the highest diagnostic performance with an AUC of 0.855.</p><p><strong>Conclusions: </strong>Serum Hs-CRP level and plaque characteristics may provide complementary information for predicting recurrent stroke. The combination of these two indicators may be a better potential predictor of the population at high risk of stroke recurrence.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70909"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Function and Efficacy of Remote Ischemic Conditioning in Acute Moderate Ischemic Stroke: A Post Hoc Analysis of RICAMIS Trial.","authors":"Xiao-Yi He, Yu Cui, Jia-Qi Wang, Lu Wang, Hui-Sheng Chen","doi":"10.1002/brb3.70831","DOIUrl":"10.1002/brb3.70831","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence supports the therapeutic potential of remote ischemic conditioning (RIC) in acute stroke management. This post hoc analysis aims to elucidate the relationship between renal function and the efficacy of RIC.</p><p><strong>Methods: </strong>This post hoc analysis utilized the complete case dataset from the RICAMIS trial, enrolling acute ischemic stroke patients with documented renal function within 48 h of symptom onset. Participants were categorized into three groups based on their estimated glomerular filtration rate (eGFR) at admission: normal (≥ 90 mL/min/1.73 m²), mildly impaired (60-89 mL/min/1.73m²), and severely impaired renal function (< 60 mL/min/1.73 m²). The primary outcome was an excellent functional outcome, defined as a modified Rankin Scale score of 0-1 at 90 days. We examined the association between RIC and functional outcomes within each renal function group, as well as the interaction between RIC efficacy and renal function, in comparison to patients receiving standard care.</p><p><strong>Results: </strong>Of the 1652 patients evaluated, 941 had normal renal function, 605 had mildly impaired renal function, and 106 had moderate to severely impaired renal function. In comparison to the control group, RIC was associated with a higher probability of achieving the primary outcome in patients with normal renal function (69% vs. 64%) and those with mildly impaired renal function (66.7% vs. 59.7%). However, this association was not observed in patients with moderate to severely impaired renal function (64.1% vs. 66%, p = 0.428). There was no significant interaction between renal function and the efficacy of RIC (adjusted p value = 0.970).</p><p><strong>Conclusion: </strong>Compared with moderate to severely impaired renal function, RIC is associated with an increased likelihood of excellent functional outcome at 90 days in patients with normal and mildly impaired renal function.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT03740971.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 10","pages":"e70831"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12504810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}