Brain and Behavior最新文献

{"title":"Dementia in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis","authors":"Omid Mirmosayyeb,&nbsp;Danial Dehghani Firouzabadi,&nbsp;Soroush Oraee,&nbsp;Mohammadreza Alinejadfard,&nbsp;Mohammad Yazdan Panah,&nbsp;Saeed Vaheb,&nbsp;Hamed Ghoshouni,&nbsp;Vahid Shaygannejad","doi":"10.1002/brb3.70588","DOIUrl":"https://doi.org/10.1002/brb3.70588","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Multiple sclerosis (MS), as an autoimmune demyelinating disorder, is associated with cognitive dysfunction. Dementia can result from severe cognitive dysfunction or other pathways in MS, but the exact mechanisms and prevalence are unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This review aimed to determine the pooled prevalence and risk of dementia in people with MS (PwMS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>This meta-analysis was performed in accordance with the guidelines established by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Embase, PubMed, Web of Science, and Scopus were comprehensively searched up to August 29, 2024, to identify observational studies that examined the prevalence or hazard ratio (HR) of dementia among PwMS. This meta-analysis used a random-effects model to calculate the pooled prevalence and risk of dementia among PwMS, where the prevalence rate and HR were the main metrics for effect size.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ten studies, including a total of 37,831 PwMS, estimated the prevalence of dementia in PwMS to be 5.31% (<i>I</i>² = 99.2%, 95% CI: 2.25%–11.98%). In addition, a meta-analysis of four studies assessed the HR of dementia among PwMS, revealing a pooled HR of 1.67 (<i>p</i> &lt; 0.01, <i>I</i>² = 73.5%, 95% CI: 1.31–2.13).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While dementia is not a common feature of MS, PwMS still have a significantly higher risk of developing it, compared to healthy indiviuals. However, the considerable variability across studies indicates that these estimates should be interpreted with caution, as inconsistencies in research approaches may have influenced the results. These findings warrant further validation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli","authors":"Aslı Çelik,&nbsp;Cemre Ural,&nbsp;Hatice Efsun Kolatan,&nbsp;Pembe Keskinoğlu,&nbsp;Mehmet Ateş,&nbsp;Zahide Çavdar,&nbsp;Osman Yılmaz,&nbsp;Mehmet Ensari Güneli","doi":"10.1002/brb3.70601","DOIUrl":"https://doi.org/10.1002/brb3.70601","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Housing conditions, which have a major impact on the welfare of laboratory animals, are an important issue in experimental research. Individually ventilated cage (IVC) and open-top cage (OTC) systems are widely used for housing laboratory mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to comprehensively investigate the effects of OTC and IVC housing conditions on the behavior, metabolism, and pain responses of laboratory mice from an animal welfare perspective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We measured body temperature, body weight, anxiety levels (using the elevated plus maze and open field test), and thermal nociceptive responses (using the hot-plate and tail-flick tests) in male albino BALB/c mice. At the end of these procedures, the mice were sacrificed, and the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT), ghrelin, and leptin were determined by ELISA, and the weight of the adrenal glands was measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>The results showed that there were significant differences in body weight, body temperature, anxiety-related behaviors, pain latency, and hormonal parameters between the OTC group and the IVC group. Compared to OTC, IVC had lower levels of leptin, especially under stress conditions, where a significant interaction between housing and stress was observed, and higher levels of ghrelin, ACTH, and CORT. IVC group also had increased body weight, adrenal gland weight, and body temperature. In the hot-plate test, the IVC group showed increased latency of hind limb responses compared to the OTC group, but not in the tail-flick test. IVC group exhibited more anxiety-related behaviors in the OFT, while no differences were observed in the EPM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>According to the results of this study, housing mice in IVCs appears to compromise welfare, altering behavioral, hormonal, and pain responses. This suggests that the IVC system can induce physiological and behavioral stress, potentially acting as a systemic confounding factor in mouse research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Teleworking on Work-Related and Home-Related Stress at During the First Global Lockdown–The International COVISTRESS Study","authors":"Sébastien Couarraze,&nbsp;Guillaume Decormeille,&nbsp;Louis Delamarre,&nbsp;Fouad Marhar,&nbsp;Karen Gbaglo,&nbsp;Raimundo Avilès Dorlhiac,&nbsp;Mickael Berthon,&nbsp;Andy Su-I Liu,&nbsp;Samuel Antunes,&nbsp;Bruno Pereira,&nbsp;Julien S Baker,&nbsp;Morteza Charkhabi,&nbsp;Ukadike C Ugbolue,&nbsp;Reza Bagheri,&nbsp;José J. Gil-Cosano,&nbsp;Marek Zak,&nbsp;The COVISTRESS Network,&nbsp;Maëlys Clinchamps,&nbsp;Frédéric Dutheil","doi":"10.1002/brb3.70592","DOIUrl":"https://doi.org/10.1002/brb3.70592","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The initial lockdown during the pandemic of COVID-19 led to adjustments in working conditions, including extensive use of telecommuting whenever possible, putatively influencing both work-related and home-related stress.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our aim was to measure the impact of teleworking on work-related and home-related during the COVID-19 pandemic.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The international study was conducted using an online questionnaire to collect demographic and stress-related data from individuals worldwide during the 2020 pandemic year. Work-related and home-related stress levels were evaluated using an uncalibrated visual analog scale, with a range from 0 (none) to 100 (maximum).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 13,537 individuals from 44 countries completed the survey between January and June 2020. A total of 7356 individuals were engaged in professional activities. Of these, 6639 continued to work, of which 2573 carried on as usual and 4066 teleworked. The teleworkers demonstrated a considerably (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) lower level of work-related stress (58 ± 31.6) in comparison to those who maintained their usual work schedule (63.6 ± 31.1). However, there was no statistically significant variation in home-related stress between the two groups. The risk of high levels of work-related stress (stress &gt; 80) was multiplied by 1.76 in women (1.54 to 2.01; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), by 1.43 (1.27 to 1.61; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) for those who did not telework, by 5.31 (4.57 to 6.18; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) for those with high levels of home-related stress (stress &gt; 80), and by 1.46 (1.22 to 1.76; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) for those from continents outside Europe. Home-related stress is also a risk factor for work-related stress, and vice versa. Sociodemographic risk factors for higher levels of home-related stress were age &lt; 50 years old, women, working &lt; 50 h per week, continents outside Europe, and not teleworking were no longer risk factors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Telework emerged as a viable option during the initial phase of the global pandemic. This mode of work was associated with lower levels of work-related stress compared to workers who were required to work in a conventional manner. In terms of home-related stress, telecommuters experienced more stress than those who continued to work as usual.&lt;/p&gt;\u0000 ","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Psychotic-Like Experiences and Brain White Matter Microstructure in Young Women","authors":"Rikka Kjelkenes,&nbsp;Sara Fernandez-Cabello,&nbsp;Irene Voldsbekk,&nbsp;Madelene Christin Holm Bukhari,&nbsp;Andreas Dahl,&nbsp;Ingvild Sandø Lofthus,&nbsp;Henning Stople Rise,&nbsp;Christian K. Tamnes,&nbsp;Ivan I. Maximov,&nbsp;Lars T. Westlye","doi":"10.1002/brb3.70587","DOIUrl":"https://doi.org/10.1002/brb3.70587","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psychotic-like experiences (PLE) represent a risk factor for later psychotic disorders and a marker for general mental distress. The connectivity and microstructure of key brain white matter pathways, including fronto–temporal trajectories, have been implicated in psychosis and psychosis-risk. Although sex differences in PLE prevalence and characteristics have been reported, most neuroimaging studies of PLE have primarily included mixed-sex, samples and little research has been carried out in females only. This study examines the associations between PLE and white matter characteristics in young to middle-aged females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed cross-sectional diffusion magnetic resonance imaging (dMRI) and self-reported data from 661 females aged 9–44 years using the 15-item version of The Community Assessment of Psychic Experiences (CAPE) questionnaire. Associations between CAPE subscales and other psychopathology measures were tested. Using linked independent component analysis (LICA), we decomposed the voxel-wise data from 24 dMRI metrics across five different diffusion models into 10 spatially independent components. We then examined the association between the LICA subject weights and age. Next, we tested for associations between the LICA subject weights and both CAPE total and subscales scores using Bayesian statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PLE were broadly associated with various domains of psychopathology and psychosocial factors. Moderate evidence emerged for an association between PLE and an LICA component reflecting a broad and complex pattern of diffusivity in major pathways, including the inferior fronto– occipital fasciculus, anterior thalamic radiation, and forceps minor. The persecutory ideations subscale showed the strongest evidence of an effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PLE in young females are associated with a distinct multimodal white matter pattern reflecting microstructural characteristics in key commissural, association, and thalamocortical pathways in young females. The findings support that LICA is a valuable tool for fusing and decomposing advanced dMRI metrics to delineate white matter patterns that show sensitivity to PLE and mental distress.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological Function and the Relationship Between Subjective Cognition, Objective Cognition, and Symptoms in Hypermobile Ehlers–Danlos Syndrome","authors":"Amber Sousa,&nbsp;Min-Kyung Jung,&nbsp;Arline Allera,&nbsp;Bernadette Riley","doi":"10.1002/brb3.70603","DOIUrl":"https://doi.org/10.1002/brb3.70603","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Hypermobile Ehlers–Danlos syndrome (hEDS), a subtype of the Ehlers–Danlos syndromes, is a connective tissue disorder that is associated with a number of cognitive and psychological symptoms. Very little research has directly examined the neuropsychological functioning profile in hEDS, but some research has found associations of hypermobility with cognitive difficulties, psychological symptoms, and structural brain differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The current research compared a 12-matched-pairs sample of individuals with hEDS to healthy controls on a comprehensive neuropsychological test battery, as well as measures of mood, pain levels, fatigue, subjective cognition, and ability to perform social activities. Participants were matched for age, gender, and years of education. A second analysis was completed for a larger group of 18 participants with hEDS to examine associations of cognition and other symptoms with subjective cognition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our results did not reveal significant cognitive differences between the two groups for most cognitive measures. However, individuals with hEDS had lower scores for delayed verbal memory recall. In the larger hEDS sample, correlations between subjective cognition, objective cognitive test performance, and other clinical variables revealed significant correlations between subjective cognition and visuospatial planning and construction, working memory, and set-shifting. Additionally, subjective cognition was associated with anxiety, depression, fatigue, pain, and the ability to participate in social activities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We conclude that cognitive difficulties reported by individuals with hEDS are likely fluctuating and may correspond with fluctuating symptoms including dysautonomia, pain, and sleep difficulties. Furthermore, subjective cognition appears to be especially correlated with other related symptoms of mood, pain, and fatigue.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Oxidative Stress Gene Protein, Expression, and DNA Methylation on Multiple Sclerosis: A Multi-Omics Mendelian Randomized Study","authors":"Yang Li,&nbsp;Yushi Wang,&nbsp;Shuning Wang,&nbsp;Hui Zhu","doi":"10.1002/brb3.70606","DOIUrl":"https://doi.org/10.1002/brb3.70606","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oxidative stress (OS) is linked to the development of multiple sclerosis (MS), but the causal relationship in terms of genetic pathophysiology remains ambiguous. We employed Mendelian randomization (MR) and colocalization analysis to explore the relationship between OS genes and MS, utilizing an integrative multi-omics approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We obtained data from a genome-wide association study (GWAS) of MS from the International Multiple Sclerosis Genetics Consortium (Discovery phase) and the FinnGen study (Replication phase). Mendelian randomization analyses were conducted using summary data to evaluate the association between molecular features of OS-related genes and MS. Additional colocalization analyses were undertaken to ascertain whether the identified signal pairs shared causal genetic variants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Integration of multi-omics data, including mQTL-eQTL and eQTL-pQTL, revealed that the <i>STAT3</i> gene is associated with MS, supported by Level 1 evidence. The <i>CR1</i> gene shows an association with MS risk, evidenced by Level 3 support. Methylation at cg24718015 and cg17833746 in the <i>STAT3</i> gene correlates with reduced expression of <i>STAT3</i>. At the protein level, high circulating levels of STAT3 are inversely associated with MS risk (OR: 0.43, 95% CI, 0.33–0.54). Elevated levels of TNFRSF1A are also linked with a decreased risk of MS (OR: 0.21; 95% CI, 0.12–0.37), while higher levels of CR1 are positively associated with an increased risk of MS (OR: 1.17; 95% CI, 1.08–1.27).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study identifies specific OS genes that are associated with MS and enhances our understanding of its pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors of Post-Lumbar Puncture Headache in Patients With Cognitive Impairment","authors":"Xinhui Wang,&nbsp;Yuchen Qiao,&nbsp;Yuchen Liang,&nbsp;Jinming Han,&nbsp;Hongyan Duan,&nbsp;Yi Tang,&nbsp;Qi Qin","doi":"10.1002/brb3.70597","DOIUrl":"https://doi.org/10.1002/brb3.70597","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cognitive impairment is prevalent among the elderly population. Cerebrospinal fluid (CSF) biomarker tests are employed to facilitate timely and differential diagnosis of cognitive dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate incidence and risk factors of post-lumbar puncture headache (PLPH) in Chinese geriatric patients with cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 254 consecutive patients with cognitive impairment were recruited between March and September 2023 and categorized into two groups: mild cognitive impairment (MCI) and dementia. Different scales, such as the short-form of the McGill pain questionnaire (SF-MPQ), facial visual analogue scale (F-VAS), revised Wong-Baker Assessment of Facial Expression Pain (FPS-R), and Chinese version of Pain Assessment Scale for Advanced Dementia (C-PAINAD), were used to evaluate the incidence of headache after lumbar puncture. Univariate and multivariate factor analyses were conducted to identify potential risk factors, with the most influential predictors included in regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among patients with cognitive disorders, the incidence of PLPH was 24.8%. The incidence and duration of headache did not differ significantly between the MCI and dementia groups. The average time of post-lumbar puncture headache (PLPH) was 22.9 h. There was no significant difference in headache scale scores between MCI patients. The incidence of PLPH in women with cognitive impairment was higher than that in men. The incidence of PLPH in cognitive impairment patients with a history of headache was significantly higher than that in cognitive impairment patients without a history of headache. However, no significant differences were observed in years of education, number of lumbar punctures, length of bed rest, and oral rehydration volume.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PLPH is more commonly observed in women, individuals with a history of headache, younger age, or lower body mass index (BMI). C-PAINAD and SF-MPQ are the preferred assessment tools for evaluating PLPH in patients with cognitive impairment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Chinese Version of the Intuitive Eating Scale-2 Adapted for Pregnant Women: Psychometric Properties and Associations With Diet Quality","authors":"Xingyi Jin,&nbsp;Jian Zhu,&nbsp;Da Pan,&nbsp;Lingzhen Sun,&nbsp;Rui Wang,&nbsp;Niannian Wang,&nbsp;Jiongnan Wang,&nbsp;Chunyan Yuan,&nbsp;Shaokang Wang,&nbsp;Guiju Sun","doi":"10.1002/brb3.70568","DOIUrl":"https://doi.org/10.1002/brb3.70568","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pregnancy is a special period that is strongly influenced by dietary interventions, and many pregnant women develop gestational diabetes caused by conditions such as poor diet. Eating behavior interventions for women during this period are therefore very important, but unfortunately, there is a lack of established studies on intuitive eating in pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study examined the psychometric properties of a Chinese version of the IES-2 scale adopted in a group of pregnant women, as well as the relationship between intuitive eating characteristics and dietary quality. A total of 581 pregnant women completed the study which included the Intuitive Eating Scale (IES-2), the Depressive Symptom Scale (EPDS), the Anxiety Symptom Scale (SAS), the Parenthood Stress Scale (PPS), and The Dietary Guidelines Adherence Index for Pregnant Women during Pregnancy (CDGCI-PW).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results show that the modified scales have good quality in the Chinese pregnant women population (CMIN/DF = 1.756, CFI = 0.925, TLI = 0.909, RMSEA = 0.037) and that the scale scores are correlated with depression and anxiety of pregnant women and correlated with overall diet quality during pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The final six factors (avoiding forbidden foods, avoiding emotional eating, body.food choice congruence, avoiding food-related coping strategies, permission to eat, and reliance on hunger and satiety cues) structure of the revised IES-2 was confirmed. Moreover, the higher the intuitive diet, the better the quality of the pregnant woman's diet will be. This scale can further assess eating behaviors in different pregnancy states within the Chinese pregnant women population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Co-Morbidities Among Children and Adolescents With Headache: Findings From a Cross-Sectional Study in Bangladesh","authors":"Sifat E. Syed,&nbsp;Mohammad S. I. Mullick","doi":"10.1002/brb3.70599","DOIUrl":"https://doi.org/10.1002/brb3.70599","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Headaches in pediatric populations are increasingly recognized as being associated with psychiatric disorders, predicting poor clinical outcomes. Despite global evidence, data from South Asia, particularly Bangladesh, remain sparse, limiting region-specific insights into this comorbidity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This descriptive, cross-sectional study was conducted in the Pediatric Neurology Departments of two tertiary care hospitals in Dhaka, Bangladesh, between July 2019 and March 2020. A total of 151 children and adolescents were assessed using the International Classification of Headache Disorders (ICHD-III beta version) for headache classification and the validated Bangla version of the Development and Well-Being Assessment (DAWBA) for psychiatric diagnoses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Tension-type headache was the most common type of headache (62.9%), followed by migraines (16.6%). Psychiatric co-morbidities were identified in 39.7% of participants, with 13.2% presenting with multiple psychiatric disorders. Anxiety disorders (19.9%) and depressive disorders (12.6%) were the most prevalent. Children experiencing frequent headaches had significantly higher rates of psychiatric co-morbidities (<i>p</i> = 0.020, 95% CI: 0.000–0.042). Logistic regression analysis revealed headache frequency as a minor but noteworthy predictor of psychiatric co-morbidity (OR = 1.06, 95% CI: 1.016–1.093).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights a high burden of psychiatric disorders among children and adolescents with headaches in Bangladesh, emphasizing the importance of psychiatric screening and multidisciplinary management approaches for pediatric headache. The findings provide valuable regional data and reinforce the need for pediatrician-psychiatrist collaboration to improve outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Herpesvirus-6 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult","authors":"Yu Xie,&nbsp;Chenrui Zhang,&nbsp;Mingchi Ma,&nbsp;Ziqian Yin,&nbsp;Liqian Chen,&nbsp;Yimiao Yang,&nbsp;Shuang Wu,&nbsp;Yuanteng Fan,&nbsp;Yan Xu,&nbsp;Dan He","doi":"10.1002/brb3.70590","DOIUrl":"https://doi.org/10.1002/brb3.70590","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Human Herpesvirus 6 (HHV-6) infections are primarily observed in immunocompromised individuals, such as those with acquired immunodeficiency syndrome or organ transplant recipients. However, its role as a pathogen in immunocompetent adults remains debated. We aimed to explore the clinical significance of HHV-6 in immunocompetent individuals by presenting a case of HHV-6-associated meningitis with concurrent lymphadenitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We describe a case of an immunocompetent adult presenting with recurrent fever and headaches.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Finding</h3>\u0000 \u0000 <p>Diagnostic evaluations included next-generation sequencing analysis identified HHV-6 in both cerebrospinal fluid specimens and lymphoid tissue samples. The patient demonstrated complete clinical resolution following a 14-day course of ganciclovir therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case underscores the need to consider HHV-6 infection in immunocompetent adults presenting with meningitis of unknown etiology. Early detection and targeted antiviral therapy may lead to favorable clinical outcomes</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}