Brain and Behavior最新文献

{"title":"KLF7 Blocks MKNK2/HIF-1 Pathway-Mediated M1 Microglia Polarization to Ameliorate Ischemic Stroke-Induced Neurological Injury","authors":"Ran Wei,&nbsp;Shuang Li,&nbsp;Lei Tang","doi":"10.1002/brb3.70850","DOIUrl":"https://doi.org/10.1002/brb3.70850","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ischemic stroke (IS) is a common neurological disease with a significant financial burden but lacks effective drugs. This study sought to explore the mechanisms underlying MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2), a gene enriched in the hypoxia-inducible factor-1 (HIF-1) signaling, in IS-related neurological injury.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Middle cerebral artery occlusion/reperfusion (MCAO/R) and oxygen-glucose deprivation/reoxygenation (OGD/R) models were used in vivo and in vitro. Rats were infected with lentiviral vectors harboring knockdown or overexpression of the target genes, followed by MCAO/R to conduct 2,3,5-triphenyltetrazolium chloride, HE, Fluoro-Jade C, and TUNEL, enzyme-linked immunosorbent assay, immunohistochemistry, and neurological deficits assessment. The regulation of Krueppel-like factor 7 (KLF7) on MKNK2 was analyzed by ChIP and dual-luciferase assays. The effects of the KLF7/MKNK2/HIF-1 axis on the M1 or M2 polarization of rat microglia were demonstrated by the transfection of knockdown or overexpression plasmids into the cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MCAO/R-treated rat brain tissues and OGD/R-treated rat microglia showed MKNK2 upregulation along with activation of the HIF-1 signaling, whereas KLF7 expression was downregulated. Knockdown of MKNK2 inhibited the HIF-1 signaling and M1 microglia polarization, whereas it promoted M2 polarization. KLF7 repressed the MKNK2 transcription, thereby achieving the same effect as the knockdown of MKNK2 in vitro, which was reversed by combined overexpression of MKNK2. Knockdown of MKNK2 or overexpression of KLF7 ameliorated MCAO/R-induced brain damage and neurological injury in rats. MKNK2 overexpression reversed the alleviating effect of KLF7 overexpression on pathological brain injury in rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Significant downregulation of KLF7 expression after IS exacerbated pathological brain damage through the MKNK2-mediated HIF-1 pathway.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Depression in College Students Using NLP and Transformer Models: Implications for Career and Educational Counseling","authors":"Qiuxia Wan,&nbsp;Yue Pan,&nbsp;Sonia Zakeri","doi":"10.1002/brb3.70828","DOIUrl":"https://doi.org/10.1002/brb3.70828","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Depression among college students is a growing concern that negatively affects academic performance, emotional well-being, and career planning. Existing diagnostic methods are often slow, subjective, and inaccessible, underscoring the need for automated systems that can detect depressive symptoms through digital behavior, particularly on social media platforms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This study proposes a novel natural language processing (NLP) framework that combines a RoBERTa-based Transformer with gated recurrent unit (GRU) layers and multimodal embeddings. The Transformer captures nuanced language patterns, while the GRU layers account for the sequence of user posts over time. Multimodal embeddings—including behavioral, temporal, and contextual metadata—enhance the model's ability to interpret subtle emotional cues in social media posts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>The model was evaluated on real-world datasets from Twitter and Reddit, achieving an accuracy of 90.18% in classifying depressive versus non-depressive posts. It also demonstrated consistently high performance across both simple and complex sentence types. Statistical comparison with several baseline models confirmed the superiority of the proposed method, particularly over traditional deep learning architectures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>By enabling real-time detection of depressive signals in social media content, the proposed framework can serve as a practical tool in academic and career counseling. It supports early identification of at-risk students and facilitates timely interventions, contributing to improved student well-being, retention, and long-term success.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active Touch Intervention Using a Rough Texture Enhances Corticospinal Excitability","authors":"Kako Tanabe,&nbsp;Sho Kojima,&nbsp;Kei Saito,&nbsp;Hideaki Onishi","doi":"10.1002/brb3.70837","DOIUrl":"https://doi.org/10.1002/brb3.70837","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>We aimed to clarify the effects of an active touch intervention using different textures on corticospinal excitability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 30 healthy individuals participated in the active touch intervention. Two tactile stimuli were used for intervention: smooth (silk) and rough (hessian) stimuli. Motor-evoked potentials were measured using transcranial magnetic stimulation to evaluate corticospinal excitability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The rough-textured stimulus increased corticospinal excitability 15 min after the intervention. In contrast, the active touch intervention that used a smooth texture did not alter corticospinal excitability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The occurrence of changes in corticospinal excitability after an active touch intervention may depend on the texture used for the intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70837","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Statistics Are Essential for Strengthening a Paper in Brain and Behavior","authors":"Michal Ordak,&nbsp;Raffaella Bosurgi","doi":"10.1002/brb3.70727","DOIUrl":"https://doi.org/10.1002/brb3.70727","url":null,"abstract":"&lt;p&gt;Brain and Behavior, launched in 2011 by Andrei V. Alexandrov, is an open-access, multidisciplinary journal dedicated to the rapid publication of original research in neurology, neuroscience, psychology, and psychiatry. Since then, the journal has expanded its scope and today it publishes studies on brain function and behavior in relation to health, social, political systems, and the environment. It accepts research in clinical and basic sciences, including descriptive studies, preliminary research, and work that involves reproducibility. The goal is to support authors in publishing research while meeting high-publication standards. Brain and Behavior's philosophy is to disseminate good and sound science. A study to be good doesn't have to be novel or ground breaking but it has to be robust and has to follow rigour in methodology and statistics. Demonstration that a result can be replicated in independent studies is key in validating novel studies and good statistics can enhance the overall impact of the studies (Alexandrov &lt;span&gt;2011&lt;/span&gt;). Statistics plays three important roles in brain studies. They include the study of differences between brains in distinctive populations, the study of variability in the structure and functioning of the brain, and the study of data reduction on large-scale brain data. These areas are illustrated through research in brain connectivity, information flow, large-scale neuroimaging data, and predictive modeling. After outlining these roles, one can consider how statistical science continues to support brain decoding and how collaboration between statistical and neurobiological communities may contribute to addressing future questions (Chén &lt;span&gt;2019&lt;/span&gt;). The most recent data suggest that we are dealing with low quality in statistical reporting (Ordak &lt;span&gt;2024&lt;/span&gt;). By providing a set of basic statistical recommendations we aim to guide authors to help improve the quality and transparency of future submissions to Brain and Behavior.&lt;/p&gt;&lt;p&gt;One key recommendation concerns effect size measures. A &lt;i&gt;p&lt;/i&gt; value indicates whether an observed effect is unlikely due to chance, but it does not communicate the strength or importance of the effect. Effect sizes allow researchers to determine how large a difference or association is and whether it may be practically or clinically meaningful. Including them supports interpretability and enables comparisons between studies. An example can be found in a study published in Brain and Behavior by Elkjaery et al., where the authors tested the emotional impact of sequentially induced anger and anxiety—emotions associated with opposing action tendencies (approach vs. avoidance) using independent samples &lt;i&gt;t&lt;/i&gt;-tests and mixed-effects ANOVAs. Emotional impact in this context refers to changes in emotional states (e.g., anger, anxiety, and irritability) and behavioral inclinations, assessed through visual and verbal measures of action tendencies, following experimental ","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of Predictive Machine Learning Model of Glioma-Associated Gut Microbiota","authors":"Ze Li,&nbsp;Kai Zhao,&nbsp;Hongyu Liu,&nbsp;Jialin Liu,&nbsp;Xu Chen,&nbsp;Wentao Hu,&nbsp;Er Wen,&nbsp;Kai Zhang,&nbsp;Ling Chen","doi":"10.1002/brb3.70843","DOIUrl":"https://doi.org/10.1002/brb3.70843","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The gut microbiota plays a crucial role in the development of glioma. With the evolution of artificial intelligence technology, applying AI to analyze the vast amount of data from the gut microbiome indicates the potential that artificial intelligence and computational biology hold in transforming medical diagnostics and personalized medicine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted metagenomic sequencing on stool samples from 42 patients diagnosed with glioma after operation and 30 non-intracranial tumor patients and developed a Gradient Boosting Machine (GBM) machine learning model to predict the glioma patients based on the gut microbiome data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The AUC-ROC for the GBM model was 0.79, indicating a good level of discriminative ability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This method's efficacy in discriminating between glioma cells and normal controls underscores the potential of machine learning models in leveraging large datasets for clinical insights.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70843","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventral Anterior–Lateral Complex of the Thalamus Mediates Chronic Stress-Induced Pain Hypersensitivity and Underlies Electroacupuncture Analgesia","authors":"Jie Chen,&nbsp;Qinling Li,&nbsp;Wei Yu,&nbsp;Min He,&nbsp;Zui Shen,&nbsp;Peipei Feng","doi":"10.1002/brb3.70855","DOIUrl":"https://doi.org/10.1002/brb3.70855","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mental disorders frequently co-occur with pain, yet pain mechanisms in non-peripheral etiologies (e.g., chronic psychological stress) remain underexplored. The ventral anterior–lateral thalamic complex (VAL) is implicated in emotional processing, but its role in chronic stress-induced pain hypersensitivity is unclear. Electroacupuncture (EA) is clinically used for pain management, but its efficacy and mechanisms in chronic stress-driven pain hypersensitivity require validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A chronic restraint stress (CRS) model was established in male mice. Behavioral assessments were performed to quantify mechanical sensitivity (hindpaws and abdomen using von Frey filaments), thermal sensitivity (hot plate test), and spontaneous pain-like behaviors. Bidirectional chemogenetic approaches targeted VAL CaMKIIα-positive neurons. EA was applied at Zusanli (ST36) and Sanyinjiao (SP6) acupoints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CRS stably induced pain hypersensitivity phenotypes, including mechanical allodynia (hindpaws/abdomen), thermal hyperalgesia, and spontaneous pain-like behaviors. Chemogenetic inhibition of VAL CaMKIIα-positive neurons reversed these CRS-induced hypersensitivity responses. Conversely, activating these neurons in naive mice recapitulated the full spectrum of hyperalgesia phenotypes. EA alleviated CRS-induced hindpaw mechanical/thermal hyperalgesia, abdominal allodynia, and spontaneous pain. EA's effects on hindpaw mechanical/thermal hyperalgesia were mediated by suppression of VAL CaMKIIα-positive neurons. In contrast, its amelioration of abdominal allodynia and spontaneous pain persisted despite chemogenetic activation of VAL CaMKIIα-positive neurons, indicating possible distinct pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study reveals the pivotal role of thalamic VAL CaMKIIα-positive neurons in chronic stress-associated pain hypersensitivity and elucidates EA's analgesic mechanisms, providing novel therapeutic strategies for emotion–pain comorbidity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70855","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145021804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide Ideation, Attempts, and Mortality in Multiple Sclerosis: A Systematic Review and Meta-Analysis","authors":"Omid Mirmosayyeb,&nbsp;Homa Khodadadi,&nbsp;Aynaz Mohammadi,&nbsp;Motahareh Abbasi,&nbsp;Saeed Vaheb,&nbsp;Mohammad Yazdan Panah,&nbsp;Mohammad Mohammadi,&nbsp;Vahid Shaygannejad","doi":"10.1002/brb3.70839","DOIUrl":"https://doi.org/10.1002/brb3.70839","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background:</h3>\u0000 \u0000 <p>Living with multiple sclerosis (MS) means facing significant obstacles in managing the unpredictable nature of this lifelong condition. Studies highlight a concerning connection between the disease and an elevated risk of suicide. In this study, we assessed the prevalence of suicide and suicide mortality risk in people with MS (PwMS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods:</h3>\u0000 \u0000 <p>A comprehensive and systematic search of Medline, EMBASE, Scopus, and Web of Science databases was conducted. Studies of any design were included if they reported at least one of the following outcomes: (1) the prevalence of suicide ideation, suicide attempts, suicide deaths, and the proportion of suicide deaths among total deaths in MS populations (2) the risk of suicide mortality in PwMS compared to healthy controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results:</h3>\u0000 \u0000 <p>The systematic review and meta-analysis included 64 studies across 19 countries, predominantly from Europe and North America, encompassing over 200,000 PwMS. The pooled prevalence of suicide ideation was 22.6% (95% CI: 16.9–28.3). Suicide attempts were reported at 3.4% (95% CI: 1.6–5.2), while suicide mortality was 0.5% (95% CI: 0.3–0.7), accounting for 2.1% (95% CI: 1.5–2.7) of total mortality in PwMS. PwMS had a significantly higher suicide mortality risk compared to healthy controls (standardized mortality ratio [SMR] = 1.49, 95% CI: 1.08–2.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion:</h3>\u0000 \u0000 <p>This study highlights the elevated suicide mortality risk among PwMS, underscoring the urgent need for integrated mental health care in MS management. Future research should explore the impact of disease-modifying therapies, protective factors, and standardized risk assessment tools to improve early intervention and reduce suicidal behavior in this vulnerable population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholder Pressure and Green Innovation: A Meta-Analytic Exploration of Industry and Regional Variations","authors":"Hasan Emin Gurler,&nbsp;Ahmet Kaya,&nbsp;Ayşe Nur Soysal Bilmiş,&nbsp;Yakup Durmaz","doi":"10.1002/brb3.70840","DOIUrl":"https://doi.org/10.1002/brb3.70840","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Stakeholder pressure is widely recognized as a key driver of green innovation. However, existing research often overlooks how this relationship may differ across various industry settings and national contexts. Understanding these contextual differences is essential for businesses aiming to implement effective and responsive environmental strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods:</h3>\u0000 \u0000 <p>This study synthesizes findings from 23 independent investigations conducted across multiple industries and countries. The analysis aims to uncover patterns in how stakeholder pressure influences green innovation, with a particular focus on variations between sectors and regional settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>The influence of stakeholder pressure on green innovation is generally positive but varies significantly by context. In manufacturing industries, the relationship is weaker, likely due to technical, operational, or financial constraints that hinder firms from fully meeting stakeholder expectations. The effect is also less pronounced in China, potentially due to country-specific stakeholder norms, regulatory frameworks, or socio-economic factors that shape corporate environmental responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both industry characteristics and national contexts significantly shape the effectiveness of stakeholder-driven green innovation. Firms need to consider these contextual nuances when developing environmental strategies. Tailoring approaches to fit specific industrial and regional conditions can improve alignment with stakeholder expectations and enhance the success of green initiatives.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Venous Thrombosis:Current Status and Challenges","authors":"Wenbo Zuo,&nbsp;Shengcai Chen,&nbsp;Jiashuo Lin,&nbsp;Yan Wan,&nbsp;Fei Cao,&nbsp;Bo Hu","doi":"10.1002/brb3.70844","DOIUrl":"https://doi.org/10.1002/brb3.70844","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cerebral venous thrombosis (CVT) is a stroke type that primarily affects young individuals, with various risk factors and complex mechanisms. It accounts for 0.5% to 3% of all stroke cases and can significantly impact daily activities and quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This review aims to classify the etiology of CVT, assess its impact on prognosis, and evaluate the best treatment approaches. It also analyzes current issues in CVT management and proposes future directions for treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive review of the literature on CVT, focusing on risk factors, treatment strategies, and outcomes. The impact of anticoagulation therapy and endovascular interventions is examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This review examines the various risk factors associated with CVT, including female-specific conditions, infections, autoimmune diseases, cancer, and mechanical triggers. It highlights the impact of these factors on the prognosis and outcomes of CVT. The effectiveness of anticoagulation therapy, both traditional and with direct oral anticoagulants, is discussed, along with the role of endovascular therapy in severe cases. The review also identifies current challenges in CVT management, such as incomplete thrombus clearance and the lack of standardized evaluation criteria for recanalization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Further research is needed to optimize CVT management, improve patient outcomes, and enhance the quality of life for affected individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between the Duration of Hospitalization and Readmission Status in Patients With Schizophrenia: A Saudi Arabian Cohort Study","authors":"Mahmoud A. Alharthi,&nbsp;Rajaa M. Al-Raddadi,&nbsp;Sulhi A. Alfakeh","doi":"10.1002/brb3.70807","DOIUrl":"https://doi.org/10.1002/brb3.70807","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The readmission of individuals with schizophrenia to inpatient care poses a significant challenge for health practitioners, as this tendency has a culminating effect on the patients and their families. The duration of hospitalization of a patient with schizophrenia in a hospital or mental health facility poses a significant burden on mental healthcare systems. This study aimed to assess the length of stay of patients with schizophrenia in a mental health facility. The relationship between the duration of hospitalization and risk of readmission for these patients was assessed with respect to the sociodemographic endpoints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included 145 individuals who were admitted to the Eradah Mental Health Complex in Jeddah from July 1, 2018 to December 31, 2018.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The present study revealed that 84.8% of the sample comprised male participants. Moreover, only 5.5% of the patients were employed, with a larger proportion being unemployed. Among the total admitted patients, 36.6% were readmitted within a year, and the average length of stay was 49.1 days. Importantly, there was no discernible relationship between the readmission status and length of stay in the present study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The current study suggested that enhancing the transition from inpatient psychiatric care to outpatient care may result in positive disease outcomes, which may possess clinical implications for reducing the length of hospitalization of patients. This can culminate in reducing the burden of disease on the patients, their families, and ultimately, the healthcare system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}