Brain and Behavior最新文献

{"title":"Mendelian Randomization Analysis Reveal the Role of Circulating Inflammatory Proteins in Mediating Functional Brain Networks and Peripheral Neuropathic Pain Effects","authors":"Wen-Hui Liu,&nbsp;Hui-Min Hu,&nbsp;Chen Li,&nbsp;Qing Shi,&nbsp;Yi-Fan Li,&nbsp;Peng Mao,&nbsp;Bi-Fa Fan","doi":"10.1002/brb3.70751","DOIUrl":"https://doi.org/10.1002/brb3.70751","url":null,"abstract":"<p><b>Objective</b>: The perception of pain is thought to arise from the integration of information between multiple brain regions. Data from observational studies indicates that dysfunction of brain resting-state functional networks is present in a wide range of peripheral neuropathic pain (pNP). The present study thus sought to investigate whether a causal relationship exists and to determine the potential mediating role of circulating inflammatory proteins in this association.</p><p><b>Methods</b>: The resting-state functional magnetic imaging phenotype is defined as a stable feature that quantifies the pattern of functional connectivity (i.e., synchronized activity) between different regions of the brain in the resting state of an individual. We gathered publicly available genome-wide association study (GWAS) summary statistics for brain functional networks, including 191 rsfMRI phenotypes and postherpetic neuralgia (PHN) and trigeminal neuralgia (TN) in the FinnGen biobank. Furthermore, data were collected on genetic variation related to inflammation, including 91 circulating inflammatory proteins. We performed two-sample MR analysis to investigate the causal effects of functional brain networks on PHN and TN. To explore the possible mediation of inflammatory factor changes between rsfMRI phenotypes and PHN and TN.</p><p><b>Results</b>: The forward MR approach identifies five rs-fMRI phenotypes that are causally associated with the risk of developing PHN. For instance, enhanced motor network connectivity was found to be associated with a reduced risk of PHN. Six rsfMRI phenotypes were identified as causally associated with TN risk. These brain network phenotypes mainly involve the default mode network (DMN), the sensory-motor network (SMN), and the motor network, etc. Two-step MR-mediated analysis revealed that the inflammatory protein interleukin 20 receptor alpha (IL-20RA) is a mediator of the pathway from the phenotype Pheno 12 of the brain motor network to PHN.</p><p><b>Conclusion</b>: The findings provide valuable insights into potential targets for disease intervention and treatment at the level of functional brain networks.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70751","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Remapping at “Point-Line-Plane” Levels With Central Dysfunction in Cerebral Small Vessel Disease","authors":"Jie Ma,&nbsp;Juan-Juan Lu,&nbsp;Xin Gao,&nbsp;Jia-Jia Wu,&nbsp;Xiang-Xin Xing,&nbsp;Mou-Xiong Zheng,&nbsp;Xu-Yun Hua,&nbsp;Jian-Guang Xu","doi":"10.1002/brb3.70773","DOIUrl":"https://doi.org/10.1002/brb3.70773","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study is aimed at investigate the glucose metabolic patterns of cerebral small vessel disease (CSVD) at “point-line-plane” levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively collected the ¹⁸F-fluorodeoxyglucose PET/MRI images of 174 CSVD patients and 206 healthy controls. First, the brain FDG-PET of each subject was divided into 7 classical networks, and the mean standard uptake value (SUV_mean) was calculated. Second, the SUV_mean of different brain networks was compared at the region of interest and voxel level. Third, the metabolic connectivity of intra- and inter-networks was compared. Fourth, the correlation of SUV_mean changes in different networks was calculated. Finally, the correlation between the SUV_mean of the whole network and each brain region within the network was analyzed in different brain networks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Increased SUV_mean was mainly shown in the right postcentral gyrus in the somatomotor network and the right superior parietal gyrus in the dorsal attention network; decreased SUV_mean was predominantly observed in the right superior temporal gyrus in the somatomotor network in the CSVD group. Significant correlations of SUV_mean alterations in varying networks and SUV_mean of the whole network and each brain region within the network were found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Affected by CSVD, the glucose metabolism redistribution is heterogeneous in different brain network, and its changes start from brain region and metabolic connectivity within the sub-brain network.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Implications of White Matter Alterations in Overweight Chinese Individuals: An NODDI and DTI Study","authors":"Shaofan Jiang,&nbsp;Yingzhe Cheng,&nbsp;Rifeng Jiang,&nbsp;Peilin Huang,&nbsp;Jiejun Zhang,&nbsp;Xiaodong Pan,&nbsp;Yunjing Xue","doi":"10.1002/brb3.70777","DOIUrl":"https://doi.org/10.1002/brb3.70777","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective:</h3>\u0000 \u0000 <p>Scarce studies have elucidated the relationship between the microstructure changes of white matter (WM) and cognitive domains in overweight (OW). This study aimed to evaluate the WM microstructure changes and the relationship with the cognitive domains and cognition-related plasma biomarkers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods:</h3>\u0000 \u0000 <p>This study recruited 77 standard weight (SW) and 42 OW participants. The WM integrity was analyzed using neurite orientation dispersion and density imaging (NODDI) and diffusion tensor imaging (DTI). The region of interest (ROI) values of NODDI and DTI were calculated and compared between groups. The correlations between WM microstructure and cognitive domains and cognition-related plasma biomarkers were also recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results:</h3>\u0000 \u0000 <p>The ROI analysis revealed significant differences in fractional anisotropy (FA) and orientation dispersion index (ODI) in extensive WM regions (<i>p</i> &lt; 0.05). Further analysis showed that NODDI parameter values of the uncinate fasciculus (UF) showed significant correlations with the cognitive domain. Additionally, other abnormal WM microstructures of OW were associated with cognitive domains and cognition-related plasma biomarkers to varying degrees.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion:</h3>\u0000 \u0000 <p>The findings evidence that abnormalities of the WM microstructure may indicate typical changes of OW, and these microstructure abnormalities are associated with cognitive functions and cognition-related plasma biomarkers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70777","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microstate Dynamics in Working Memory: Exploring Spatial Information Coding of Stimulus and Behavioral Performance","authors":"Hamideh Norouzi,&nbsp;Mohammad Reza Daliri","doi":"10.1002/brb3.70765","DOIUrl":"https://doi.org/10.1002/brb3.70765","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>EEG microstate analysis provides insights into the spatial and temporal dynamics of brain activity during cognitive tasks. The four canonical microstates (classes A, B, C, and D) have been widely reported and associated with various cognitive functions. However, the relationship between microstate parameters and behavioral responses in cognitive functions, such as working memory (WM), has not been sufficiently investigated. This study investigates how microstate dynamics relate to WM performance during a memory-guided saccade (MGS) task.</p>\u0000 \u0000 <section>\u0000 \u0000 <h3>1.1 Methods</h3>\u0000 \u0000 <p>EEG and Eye-tracking data were recorded from participants performing an MGS task at two target eccentricities (near and far). Saccade error was used as a behavioral index of WM performance. Microstate parameters (occurrence, coverage, duration, and transition probability) were computed for the four canonical microstates during the trials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3>1.2 Results</h3>\u0000 \u0000 <p>Our analysis revealed a significant reduction in the coverage of microstate C, often associated with the default mode network, during the memory maintenance interval compared to baseline. Moreover, a notable increase was observed in the duration of microstate D, considering polarity during the memory interval, which could be related to the frontoparietal control network (FPCN). Notably, the transition probability (TP) from D+ to D- during the memory duration correlated with saccade errors, indicating a behavioral predictive capacity. Furthermore, we identified distinct patterns of microstate D transitions to other microstates that differed significantly between the near and far target conditions, suggesting a functional role in spatial coding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3>1.3 Conclusion</h3>\u0000 \u0000 <p>Microstate dynamics, particularly those of microstate D, play a dual role in spatial WM by supporting information coding and predicting behavioral accuracy. The polarity-specific transitions within microstate D provide a neural signature of WM performance, with implications for understanding network-level mechanisms underlying spatial memory and saccade control.\u0000</p>\u0000 </section>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014","authors":"Pingping Huang,&nbsp;Gaocan Ren,&nbsp;Yifei Wang,&nbsp;Yicheng Liu,&nbsp;Hongwei Zhang,&nbsp;Shuangqing Fu,&nbsp;Zhibo Zhang,&nbsp;Lijun Guo,&nbsp;Xiaochang Ma","doi":"10.1002/brb3.70768","DOIUrl":"https://doi.org/10.1002/brb3.70768","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atherosclerosis is the primary cause of cerebrovascular disease, which in turn has substantial deleterious impacts on cognitive abilities. The atherogenic index of plasma (AIP), calculated as the logarithmic transformation of the ratio of triglycerides to high-density lipoprotein cholesterol (log[TG/HDL-C]), has emerged as a novel biomarker reflecting the balance between proatherogenic and antiatherogenic lipoproteins. Nevertheless, the association between AIP and cognitive function has not been examined in a large cohort. This study examined the relationship between AIP and cognitive performance in a nationally representative cohort of adult Americans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted using data from the 2011–2014 National Health and Nutrition Examination Survey (NHANES). The relationship between AIP and cognitive function was examined using several multivariate regression models with adjustment for arrays of potential confound factors. Fitted smoothed curves and threshold effect analysis were used to characterize possible nonlinear relationships.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study population comprised 995 adults (mean age 63.01 ± 14.93 years; 51.86% female), with 49.65% identifying as non-Hispanic White, 9.15% as Mexican American, and 20.2% as non-Hispanic Black. Higher AIP was associated with greater risk of cognitive impairment. Negative correlations were detected between the AIP and both Animal Fluency Test (AFT) performance (β = -5.54, 95%CI: -9.26, -1.82, <i>p</i> &lt; 0.05) and Digit Symbol Substitution Test (DSST) performance (β = -15.79, 95% CI: -26.32, -5.27, <i>p</i> &lt; 0.05) after adjusting for multiple confounding variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Elevated AIP is associated with cognitive impairment in adult Americans.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Self-medication Practices Among Healthcare Providers With Migraine in Saudi Arabia","authors":"Bandar Nasser Aljafen,&nbsp;Jodi Mohamad Alkahwaji,&nbsp;Sarah Amin Alamoudi,&nbsp;Shaimaa Tawfik Jamous,&nbsp;Sara Mohammed Almesfer,&nbsp;Aljohrah Sultan Alanazi,&nbsp;Fatima Yahya Al-Aidaros","doi":"10.1002/brb3.70724","DOIUrl":"https://doi.org/10.1002/brb3.70724","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Migraine is a neurological disorder characterized by recurrent headaches resulting from abnormal regulation of sensory input to the head. Self-medication (SM) is a prevalent practice among healthcare providers (HCPs), with potentially detrimental consequences. This study aims to investigate SM practices among HCPs in Saudi Arabia, specifically focusing on their management of migraines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study was conducted in Riyadh, Saudi Arabia, using an electronic self-administered questionnaire. This study encompassed various categories of healthcare professionals in Riyadh.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 1054 participants, 165 healthcare professionals reported SM for migraine headaches. The primary reasons for this practice included perception of having sufficient information about the disease and its management (60.0%), ease of medication access (53.9%), and busy schedule (46.7%). The most commonly overused self-prescribed medications for migraines were paracetamol (70.9%) and nonsteroidal anti-inflammatory drugs (NSAIDs) (43.0%), both classified as over the counter medication. Out of the 165 self-medicating HCPs with migraines, approximately half (53.2%) reported that the medication was effective in the treatment of migraine, and the majority (78.5%) reported no side effects from self-medication. The 55.8% of participants were unaware of the term “medication-overuse headaches” (MOH). SM was significantly correlated with the specialty of the HCP (<i>p</i> &lt; 0.001), as was perceiving headache as a migraine (<i>p</i> &lt; 0.001). Significant positive correlations were observed between certain SM drugs and the reported side effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A high prevalence of headache was observed among HCPs in Saudi Arabia. Perceived sufficient information about the disease and its management, accessible medications, and a busy schedule were among the most common reasons for SM among HCPs with migraines. Moreover, most participants were unfamiliar with the term MOH and needs immediate attention and implement targeted policies and educational programs, including mandatory continuing medical education (CME) focused on MOH diagnosis, and management. Additional studies are required to identify other contributing factors or unintended complications associated with SM among healthcare professionals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics Analysis of Vestibular Migraine Combined With Unruptured Intracranial Aneurysm","authors":"Yaoheng Zhang,&nbsp;Yi Ju,&nbsp;Chunling Liu,&nbsp;Hui Li,&nbsp;Yanlu Jia,&nbsp;Shuning Sun,&nbsp;Haozhe Yin,&nbsp;Suisui Ma,&nbsp;Wenbo Peng","doi":"10.1002/brb3.70782","DOIUrl":"https://doi.org/10.1002/brb3.70782","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with vestibular migraine (VM) and those with migraine accompanied by unruptured intracranial aneurysm (UIA) may face an increased risk of UIA rupture. This study investigated the rupture risk of UIA in patients with VM and proposed a plausible explanation for the associations between VM, migraine, and UIA distribution, particularly concerning interactions within vascular and nociceptive conduction pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional case-control study involving 148 subjects diagnosed with UIA was conducted, who were categorized into three groups: the VM, the migraine, and the control groups. The distribution of parent arteries and the morphological parameters of the UIA, such as diameter, size, depth, neck width, mean parent arterial diameter, size ratio, non-spherical index (NSI), and parameters specific to bifurcation UIA, were extracted from the original imaging data and 3D-Slicer software for intergroup comparison.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>UIA was predominantly located in the internal carotid arteries (ICA) at C4 (12.3%), C5 (14.0%), and C7 (35.1%) in the VM group. The migraine group exhibited UIA primarily in the ICA at C6 (42.2%) and the vertebrobasilar artery (10.9%). In the control group, UIA was concentrated in the middle cerebral artery (22.6%). These distributions differed significantly (<i>p₁</i> = 0.002, <i>p₃</i> = 0.017). Furthermore, a statistically significant difference was observed in the NSI between the VM and migraine groups (<i>p</i> = 0.044).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We observed significant differences in the distribution of UIA between the VM and migraine groups compared to the control group. Furthermore, intergroup comparisons of morphological parameters indicated that both VM and migraine patients have a higher risk of aneurysm rupture. We propose a plausible hypothesis regarding the relationship between VM, migraine, and UIA distribution. Future research should involve more precise hemodynamic analyses, long-term patient follow-up, and potential animal studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Quality of Life in Myasthenia Gravis Patients: Results From a Cross-Sectional Study in South of Iran","authors":"Fatemeh Khodakarami,&nbsp;Arashk Mallahzadeh,&nbsp;Mohammad Fararouei,&nbsp;Abbas Rahimi Jaberi,&nbsp;Maryam Owjfard","doi":"10.1002/brb3.70680","DOIUrl":"https://doi.org/10.1002/brb3.70680","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterized by fatigue and muscle weakness, often leading to significant impairments in quality of life (QOL). This single-center cross-sectional study investigated factors influencing QOL among MG patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-two participants diagnosed with MG were assessed using the MG Foundation of America (MGFA) classification and the MG composite (MGC) scale for disease severity. Patients completed validated questionnaires, including the Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), MG Activities of Daily Living (MG-ADL), and the MG Quality of Life 15-item scale (MG-QOL). Family stress levels were self-reported and categorized as “Rarely/Never,” “Sometimes,” “Often,” or “Always.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis revealed no significant differences in QOL scores based on sex, disease type, presenting symptoms, thymectomy status, or BMI. Employed or freelance patients exhibited significantly lower QOL and higher fatigue compared to retired or housewife groups. Higher family stress correlated with increased fatigue, worse MGC scores, and poorer QOL. Regression analysis identified the MG-ADL and FSS scores as the strongest predictors of QOL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>QOL in MG is influenced by complex interactions among functional, social, and occupational factors. These findings emphasize the need for tailored interventions to address fatigue and support occupational and familial well-being in MG patients. Further research with larger cohorts is warranted to refine these insights and guide clinical strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System","authors":"Yanlin Liu,&nbsp;Yuting Jin,&nbsp;Yuxin Liu,&nbsp;Jiaqi Gao,&nbsp;Xiaomei Wang,&nbsp;Hongbin Ren,&nbsp;Yabo Hao,&nbsp;Xibin Yang,&nbsp;Kaitao Luo","doi":"10.1002/brb3.70740","DOIUrl":"https://doi.org/10.1002/brb3.70740","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This research focused on investigating acupuncture's effect on brain injury in middle cerebral artery occlusion (MCAO) rats and elucidating its potential mechanisms, with a focus on transcriptomic and protein-level changes related to the complement system, which may be involved in acupuncture's therapeutic effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An MCAO rat model was established and treated with acupuncture. Brain tissue from the infarct area was analyzed through RNA sequencing, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein–protein interaction (PPI) analyses, followed by qRT-PCR and western blot validation of key complement-related genes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1792 differentially expressed genes (DEGs) were identified between the MCAO and acupuncture groups. Of these, 254 hub genes were associated with acupuncture's therapeutic effects. Seven complement-related genes (C1QA, C1QB, C1QC, C2, C6, C7, and TREM2) were significantly downregulated by acupuncture. Functional enrichment revealed that these genes were involved in the inflammatory response, coagulation cascades, blood‒brain barrier regulation, and neutrophil extracellular trap (NET) formation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings suggest that acupuncture alleviates stroke-induced brain injury by modulating key components of the complement system and associated inflammatory pathways. These results provide mechanistic insights supporting the use of acupuncture as an adjuvant therapy for poststroke neuroinflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Link Between the Gut Microbiota and Epigenetic Factors in Anorexia Nervosa","authors":"N. M. Korten,&nbsp;A. C. Thelen,&nbsp;C. Voelz,&nbsp;C. Beyer,&nbsp;J. Seitz,&nbsp;S. Trinh,&nbsp;L. Blischke","doi":"10.1002/brb3.70733","DOIUrl":"https://doi.org/10.1002/brb3.70733","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Anorexia nervosa (AN) is an often chronic eating disorder that involves genetic, neurohormonal, and epigenetic factors along with key contributions from the microbiota–gut–brain axis. However, interactions between these factors are poorly understood. Recent studies have emphasized the microbiota–gut–brain axis and epigenetic changes as potentially important contributors to AN. Exploring these interactions may improve understanding of the etiology and persistence of AN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Studies specifically addressing microbial–epigenetic interactions in AN remain limited. However, similar associations have been documented in related disorders such as obesity and depression, providing potential models for AN research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Research in obesity has shown that dietary factors influence the composition of the gut microbiota and subsequent epigenetic modifications, affecting metabolic parameters and disease progression. Similarly, in depression, microbially produced metabolites influence brain function and epigenetic processes, contributing to neuropsychiatric symptoms. In AN, altered microbial composition may affect weight regulation and epigenetic patterns. Therapies targeting the microbiome, such as fecal microbiota transplantation, are under investigation for AN, highlighting the potential therapeutic utility of ameliorating microbial dysbiosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This article highlights the importance of investigating microbial–epigenetic interactions in AN. By drawing parallels with obesity and depression, we aim to deepen our understanding of AN mechanisms and ultimately improve patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}