Brain and Behavior最新文献

{"title":"Machine Learning-Based Classification of Conduct Disorder Comorbidity in Youth With ADHD.","authors":"Büşra Çağır, Rifat Kurban, Sevgi Özmen","doi":"10.1002/brb3.71784","DOIUrl":"10.1002/brb3.71784","url":null,"abstract":"<p><strong>Purpose: </strong>To identify clinical profiles associated with conduct disorder (CD) among adolescents with attention-deficit/hyperactivity disorder (ADHD) using integrated statistical and machine learning approaches.</p><p><strong>Methods: </strong>A total of 138 adolescents aged 11-18 years (100 ADHD; 38 ADHD+CD) were assessed using multidimensional sociodemographic and psychometric measures. Ninety-nine variables were analyzed. Feature selection and classification analyses were performed using χ² and mRMR methods combined with supervised machine learning models, including logistic regression, support vector machine (SVM), decision tree, random forest, gradient boosting, and artificial neural networks. Model performance was evaluated using accuracy, recall, specificity, and the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Low maternal education, disciplinary punishment, school absenteeism, medication-free periods, peer smoking and delinquency, family criminal history, physical abuse, and later ADHD diagnosis (≥12 years) consistently emerged as key factors associated with CD. In the exploratory comparison, the Top-20 SVM had the highest observed accuracy and F1-score among the evaluated configurations (accuracy = 0.87; AUC = 0.90; F1-score = 0.71), with high specificity and moderate sensitivity; no single model-selection metric was prespecified.</p><p><strong>Conclusion: </strong>These findings demonstrate that machine learning can identify clinical profiles associated with CD comorbidity in adolescents with ADHD. Such approaches may complement comprehensive clinical assessment but should not be interpreted as tools for predicting future CD development.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71784"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication Difficulties and Associations With Health Literacy, Medication Beliefs, and Adherence in Multiple Sclerosis.","authors":"Sawsan Khdair, Walid Al-Qerem, Dunia Basem, Judith Eberhardt, Lama Sawaftah","doi":"10.1002/brb3.71749","DOIUrl":"10.1002/brb3.71749","url":null,"abstract":"<p><strong>Introduction: </strong>Communication difficulties are a common but under-recognized feature of multiple sclerosis (MS) and can affect quality of life, social participation, and engagement with health care. The extent to which communication functioning is associated with health literacy, medication beliefs, and adherence in MS remains poorly understood.</p><p><strong>Methods: </strong>This cross-sectional study included 307 adults with MS recruited from Al-Bashir Hospital in Amman, Jordan. Participants completed validated Arabic versions of the Communication and Language Assessment Questionnaire for Multiple Sclerosis (CLAMS), the Health Literacy Survey-12 (HLS-Q12), the Beliefs about Medicines Questionnaire (BMQ), and the Medication Adherence Report Scale (MARS-5). Sociodemographic data were collected. Quantile regression analysis was used to examine associations between communication functioning and health literacy, medication beliefs, adherence, and sociodemographic factors.</p><p><strong>Results: </strong>Communication difficulties were commonly reported, particularly problems with word finding, maintaining a train of thought, remembering information, and following conversations. Lower health literacy scores were significantly associated with higher CLAMS scores, indicating greater communication difficulties. Higher medication concern scores were also independently associated with poorer communication functioning. Lower educational attainment was linked to higher CLAMS scores. Medication adherence, necessity beliefs, age, sex, employment status, and income were not significantly associated with communication functioning in the adjusted model.</p><p><strong>Conclusion: </strong>Communication difficulties are prevalent among adults with MS and are closely linked to health literacy and medication-related concerns. Addressing these factors may support more effective communication, improved self-management, and better engagement with care.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71749"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal Volume Mediates the Association Between Serum Ferritin and Cognition in Non-Dialysis End-Stage Renal Disease Patients.","authors":"Jingjing Si, Minghua Zhu, Mingzhe Dai","doi":"10.1002/brb3.71777","DOIUrl":"10.1002/brb3.71777","url":null,"abstract":"<p><strong>Objective: </strong>Quantitatively assess the characteristics of brain volume in end-stage renal disease (ESRD) individuals through high-resolution structural MRI, analyze the relationship between these features and cognitive impairment, as well as explore associated risk factors.</p><p><strong>Methods: </strong>Fifty ESRD subjects and 48 healthy controls, matched by demographics, participated in the study. Each participant underwent neuropsychological assessments and 3.0T MRI scans, with cerebral volume data obtained via voxel-based morphometry.</p><p><strong>Results: </strong>ESRD patients showed significantly lower scores in mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA), along with reduced gray matter volume (GMV) that was positively correlated with cognitive scores. After adjusting for confounding factors, serum ferritin levels independently served as a risk factor contributing to the decrease in GMV, with hippocampal volume partially mediating the ferritin-cognition association.</p><p><strong>Conclusions: </strong>Lower serum ferritin levels may exert a protective effect against the decrease in gray matter volume and the deterioration of cognitive function in non-dialysis ESRD individuals.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71777"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Self-Compassion on Self-Care With the Mediating Role of Illness Perception in Patients With Multiple Sclerosis Referred to Sina Hospital: Based on the Leventhal Model.","authors":"Ali Bagheri, Amir Sam Kianimoghadam, Zahra Ebadi, Abbas Masjedi-Arani, Maryam Amini-Fasakhoudi","doi":"10.1002/brb3.71772","DOIUrl":"10.1002/brb3.71772","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a chronic neurodegenerative disorder associated with diverse physical and psychological challenges. Effective self-care behaviors are essential for managing symptoms and improving quality of life. Psychological constructs such as self-compassion and illness perception are key determinants of self-management in chronic illness.</p><p><strong>Objective: </strong>This study investigated the role of self-compassion in promoting self-care behaviors among patients with MS, emphasizing the mediating role of illness perception based on Leventhal's Common-Sense Model.</p><p><strong>Methods: </strong>A cross-sectional analytical study was conducted among 360 patients with MS referred to Sina Hospital, Tehran. Participants completed the Self-Care of Chronic Illness Inventory (Version 4.c), Revised Illness Perception Questionnaire (IPQ-R), and Self-Compassion Scale (SCS). Structural equation modeling (SEM) was used to examine direct and indirect relationships between self-compassion, illness perception dimensions, and self-care behaviors. Model fit was evaluated using χ²/df = 2.52, CFI = 0.843, TLI = 0.825, RMSEA = 0.065, and SRMR = 0.084.</p><p><strong>Results: </strong>Self-compassion had a significant positive direct effect on self-care (β = 0.30, p = 0.006). Indirect effects were also found through personal control (β = 0.15, p = 0.004), emotional representation (β = 0.22, p = 0.011), and illness coherence (β = 0.15, p = 0.030). Other illness perception dimensions, including treatment control and timeline beliefs, did not show significant mediation effects (p > 0.05).</p><p><strong>Conclusion: </strong>Self-compassion promotes self-care behaviors in MS patients both directly and indirectly by enhancing adaptive illness perceptions-particularly personal control, illness coherence, and emotional balance. Interventions aimed at fostering self-compassion and reframing maladaptive illness perceptions may strengthen disease self-management and psychological well-being.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71772"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for Poststroke Dysphagia: An NTS-Centered Hypothesis-Generating Framework Linking the Brainstem Swallowing Network, Neuroimmune Regulation, and Vagal Anti-Inflammatory Signaling.","authors":"Wei Li, Lebin Liu, Yingying Tu, Chongjiu Gong, Xiao Ran, Jiuguo Pei","doi":"10.1002/brb3.71732","DOIUrl":"10.1002/brb3.71732","url":null,"abstract":"<p><strong>Background: </strong>Poststroke dysphagia (PSD) may reflect not only focal motor pathway injury but also instability of the brainstem swallowing network under neuroimmune, glial, and vascular microenvironmental stress.</p><p><strong>Methods: </strong>This mechanism-oriented narrative review synthesized evidence on swallowing central pattern generator (CPG) organization, nucleus tractus solitarius (NTS)-related sensory integration within the medullary swallowing network, poststroke neuroinflammation, altered glial responses, blood-brain barrier/neurovascular unit (BBB/NVU) dysfunction, vagus-related anti-inflammatory regulation, and acupuncture-mediated neuromodulation.</p><p><strong>Results: </strong>Evidence suggests that inflammatory amplification, altered glial responses, and BBB/NVU instability may be associated with reduced reserve in the distributed medullary swallowing network. Within this broader dorsal and ventral swallowing circuitry, the NTS contributes to sensory integration and premotor organization rather than serving as the sole center of swallowing pattern generation. Such disturbances may contribute to respiratory-swallow discoordination in vulnerable patients. Acupuncture and electroacupuncture may indirectly support swallowing-network recovery by modifying inflammatory burden, glial state, autonomic balance, and microenvironmental permissiveness. However, most mechanistic evidence is derived from ischemic stroke models in which swallowing was not the primary outcome.</p><p><strong>Conclusion: </strong>We propose an NTS-focused, hypothesis-generating framework in which acupuncture may support PSD recovery by modifying neuroimmune, glial, vascular, and autonomic background conditions relevant to brainstem swallowing-network stability. This framework should not be interpreted as evidence that acupuncture directly acts through a confirmed NTS-vagal anti-inflammatory pathway. Future studies should distinguish direct PSD evidence from indirect mechanistic evidence, stratify patients by inflammatory burden and autonomic tone, and incorporate physiological proxies of respiratory-swallow phase stability as mechanistically informative outcomes.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71732"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Different Severities of Anxiety on Decision-Making.","authors":"Yutong Ma, Yingfeng Tan, Fan Xu, Jiayi Chen, Yuxian Chen, Fangfang Liu, Meng Fan, Qin Han","doi":"10.1002/brb3.71704","DOIUrl":"10.1002/brb3.71704","url":null,"abstract":"<p><strong>Purpose: </strong>The effects of anxiety on the brain exist universally; however, little is known about how anxiety affects the functional connectivity of the cerebral cortex and various brain regions. We aimed to understand the relationship between levels of anxiety and decision-making.</p><p><strong>Method: </strong>In this study, 58 healthy adult students with an average age of 20 years were recruited. We then estimated their severity of anxiety by using the Self-Assessment Scale (SAS) for anxiety, grouping them into three severity groups according to their SAS results. Next, we performed a 24-point number crunching. During this process, the participants' facial expressions and vital signs were also recorded, while functional near-infrared spectroscopy (fNIRS) was used to measure changes in participants' hemoglobin in specific cortical areas.</p><p><strong>Finding: </strong>The moderate-anxiety group demonstrated superior outcomes compared to the other groups. Specifically, they exhibited more efficient functional connectivity in the brain, smoother hemodynamic changes (primarily reflected by HbO signals, which were selected as the main indicator due to their high sensitivity to task-evoked cerebral activation), and more positive physiological indicators during the decision-making task.</p><p><strong>Conclusion: </strong>The study concludes that a moderate-anxiety state appears to enhance brain functional connectivity, thereby improving decision-making ability and accuracy. This research provides valuable insights into the neural mechanisms through which varying severity of anxiety influences cognitive functions like decision-making.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71704"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Multiple Intelligences Among Older Adults: Development and Validation of the Multiple Intelligence Scale for Older People.","authors":"Tzu-Yu Lin, Ikeuchi Tomoko, I-Hua Chen, Servet Üztemur, Mark D Griffiths, Chung-Ying Lin","doi":"10.1002/brb3.71762","DOIUrl":"10.1002/brb3.71762","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have supported a multidimensional view of intelligence, particularly the concept of multiple intelligence (MI). However, the application and comprehensive understanding of MI in the context of aging have been explored infrequently. The present study aimed to develop and validate the Multiple Intelligence Scale for Older People (MISFOP) for community-dwelling older adults, incorporating spiritual intelligence and ensuring cultural sensitivity through translation, adaptation, and psychometric validation.</p><p><strong>Methods: </strong>The research comprised two studies to develop and validate the Chinese MISFOP. Study 1 involved translation and adaptation through expert review and pilot testing. Study 2 evaluated the 36-item instrument with 428 older adults using exploratory structural equation modeling (ESEM) and correlations with the Montreal Cognitive Assessment (MoCA).</p><p><strong>Results: </strong>ESEM resulted in a 29-item scale comprising an eight-factor structure, merging intrapersonal and spiritual intelligences due to theoretical insights and statistical considerations. The revised model showed excellent fit using the comparative fit index (CFI = 0.991), non-normed fit index (NNFI = 0.982), root mean square error of approximation (RMSEA = 0.020), and standardized root mean square residual (SRMR = 0.017), with high internal consistency for the total scale (Cronbach's α = 0.91). Significant positive associations were found between MoCA scores and linguistic (β = 0.36, p < 0.001), logical-mathematical (β = 0.26, p = 0.007), and the combined intrapersonal/spiritual intelligence (β = 0.23, p = 0.001).</p><p><strong>Conclusion: </strong>The findings suggest associations between specific MI domains and cognitive health, indicating potential applications in geriatric care. Moreover, further research with larger, longitudinal samples across different cultural contexts is necessary.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71762"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Disparities in Aspiration Pneumonitis Mortality With Co-Listed Stroke Among US Adults, 1999-2024: A CDC WONDER Analysis.","authors":"Mirza Ammar Arshad, Shiza Talib Butt, Wahhaj Munir, Muhammad Hassan Daniyal, Rohan Ahmad Daud, Warda Ikram, Rijas Ramish, Isbah Aman, Maryam Aslam, Hafiz Ahmad Masood, Asad Ali Ahmed Cheema","doi":"10.1002/brb3.71739","DOIUrl":"10.1002/brb3.71739","url":null,"abstract":"<p><strong>Background: </strong>Aspiration pneumonitis is a serious poststroke respiratory complication, yet contemporary US mortality trends involving aspiration pneumonitis as the underlying cause of death with co-listed stroke remain unclear. We evaluated national trends and disparities in aspiration pneumonitis mortality with co-listed stroke among US adults aged ≥ 25 years from 1999 to 2024.</p><p><strong>Methods: </strong>We conducted a retrospective, population-based serial cross-sectional analysis of CDC WONDER multiple cause of death data from 1999 through 2024. Deaths were included when aspiration pneumonitis (ICD-10 J69.0) was the underlying cause and stroke (I60-I69) was a contributing cause among adults aged ≥ 25 years. Age-adjusted mortality rates (AAMRs) per 100,000 population were standardized to the 2000 US population; age-specific rates were crude. Joinpoint regression estimated annual percent changes (APCs) and average annual percent changes (AAPCs).</p><p><strong>Results: </strong>A total of 296,691 deaths were identified. The overall AAMR declined from 9.20 in 1999 to 3.55 in 2024 (AAPC, -3.66%; 95% CI, -4.34 to -2.97, p < 0.001). Mortality declined among men from 13.38 to 4.92 (AAPC, -3.85%) and women from 6.79 to 2.46 (AAPC, -3.92%; both p < 0.001). Mortality declined across all census regions, including Northeast (AAPC, -3.98%; p < 0.001), Midwest (AAPC, -3.76%; p < 0.001), South (AAPC, -3.93%; p < 0.001), and West (AAPC, -3.57%; p < 0.001), with the South having the higher AAMR (3.88) in 2024. Mortality remained higher in nonmetropolitan counties, with AAMR declining from 9.96 in 1999 to 4.42 in 2020 (AAPC, -4.05%; p < 0.001), compared with metropolitan counties, where the AAMR declined from 9.02 to 3.80 (AAPC, -4.31%; p < 0.001). Among non-Hispanic Black adults, the 2014-2024 trend was stable (APC, 1.13%; p = 0.12). Rates increased after 2010 among adults aged 35-44 years (APC, 6.65%; p < 0.001), 45-54 years (APC, 4.70%; p < 0.001), and 55-64 years (APC, 3.96%; p < 0.001).</p><p><strong>Conclusion: </strong>Aspiration pneumonitis mortality with co-listed stroke declined nationally, but progress was uneven, with persistent demographic, regional, and rural disparities.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71739"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148965928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reward Prediction Errors Drive Reinforcement Learning and Recognition Memory: Gender Differences in Methamphetamine Abusers.","authors":"YuQing Liu, Die Wang, LePing Wang, SongSong Wang, ZhiYing Chen, Tiancheng Wang, Shengyi Jin, Qiang Zhou, Liping Yang","doi":"10.1002/brb3.71630","DOIUrl":"10.1002/brb3.71630","url":null,"abstract":"<p><strong>Objectives: </strong>Methamphetamine (MA) abusers have impaired executive functioning with gender differences, which may be related to the reward prediction errors (RPEs) that drive reinforcement learning and recognition memory, as RPE signaling is impaired in MA abusers. We examined whether the driving effects of RPE on reinforcement learning and recognition memory are impaired in MA abusers and how they differ between women and men.</p><p><strong>Methods: </strong>Eighty-two MA abusers (43 men, 39 women) from Zhejiang Compulsory Isolation Drug Rehabilitation Center and 86 non-users (45 men, 41 women) from Wenzhou medical university were recruited in this experimental study. We employed a behavioral paradigm adapted from Rouhani et al., which included a learning task and a recognition test. In the learning task, participants underwent a cycle of prediction and feedback, using the outcomes to iteratively adjust their subsequent choices. Reward prediction errors were manipulated by giving different monetary reward feedback after each reward prediction.</p><p><strong>Results: </strong>MA abusers showed significant impairments in learning rates and recognition accuracy compared with non-users. GLMM analysis revealed gender-specific patterns: the moderating effect of group on the RPE-learning relationship was significant in females but not in males, indicating impaired RPE utilization in female abusers.</p><p><strong>Conclusion: </strong>These findings suggest that methamphetamine abuse impairs RPE-dependent learning and memory, with reduced RPE utilization efficiency specifically observed in female abusers-manifested as larger prediction errors but lower learning rates.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71630"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress.","authors":"Rui Wang, Pengling Ren, Xia Ma, Linkun Cai, Tingting Zhang, Fengxia Yu, Liang Zhu, Zhenghan Yang, Yawen Liu, Zhenchang Wang, Peng-Gang Qiao","doi":"10.1002/brb3.71764","DOIUrl":"10.1002/brb3.71764","url":null,"abstract":"<p><strong>Background: </strong>Neurovascular coupling (NVC) is essential for regulating brain metabolism and energy supply and may be altered under acute stress. This study aimed to investigate how acute stress induced by dobutamine affects NVC.</p><p><strong>Materials and methods: </strong>This study enrolled 38 healthy participants undergoing a resting-state fMRI scan and an arterial spin labeling MRI scan prior to and during a stress test induced by dobutamine. Amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and cerebral blood flow (CBF) were calculated. Acrossvoxel CBF-ReHo and CBF-ALFF correlations were analyzed to evaluate the NVC within the whole gray matter, and the regional NVC of the brain was assessed with the CBF/ReHo and CBF/ALFF ratios.</p><p><strong>Results: </strong>The blood pressures at the ventricle systolic state (SBP) and diastolic state (DBP) were significantly increased after the infusion of dobutamine. The CBF/ReHo ratios in the postcentral cortex and the middle cingulate cortex under stress were significantly higher and lower, respectively, than the CBF/ReHo ratios in the postcentral cortex and the middle cingulate cortex under the resting state. Logistic regression analysis showed that DBP in the resting state (odds ratio [OR] 0.817, 95% confidence interval [CI] 0.692-0.965, p = 0.017) and SBP in the stress state (OR 1.218, 95% CI 1.067-1.390, p = 0.004) were significantly related to the increase in CBF/ReHo ratios in the left postcentral cortex.</p><p><strong>Conclusion: </strong>Dobutamine-induced acute stress modulated NVC dynamics. Participants with lower DBP in the resting state and higher SBP during acute stress were more prone to have increased NVC induced by stress.</p><p><strong>Relevance statement: </strong>Acute cardiovascular stress induced by dobutamine altered neurovascular coupling dynamics, and individuals with lower resting diastolic pressure and greater systolic responses showed stronger stress-related NVC enhancement.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71764"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}