A Single Session of tDCS Stimulation Can Modulate an EEG Microstate Associated With Anxiety in Patients With Depression

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-05-19 DOI:10.1002/brb3.70580

Keiichiro Nishida, Shota Minami, Tomonari Yamane, Satsuki Ueda, Banri Tsukuda, Shunichiro Ikeda, Daisuke Haruna, Masafumi Yoshimura, Tetsufumi Kanazawa, Thomas Koenig

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引用次数: 0

Abstract

Purpose

Microstate analysis involves examining the temporal dynamics of electroencephalogram (EEG) signals and serves as a crucial method for exploring the neural basis of psychiatric disorders. This study investigates the effects of transcranial direct current stimulation (tDCS) on specific microstate parameter maps-D and C in patients with depression, specifically targeting the dorsomedial prefrontal cortex (DMPFC) and left dorsolateral prefrontal cortex (DLPFC).

Methods

We conducted an open-label, between-subject, crossover trial involving 19 patients clinically diagnosed with depression. A 1 mA electrical current was administered, with anodal stimulation specifically targeting the DMPFC or the left DLPFC. Microstate maps were derived from resting-state EEG recordings obtained prior to and following the application of tDCS. The EEG data were categorized into five distinct microstate classes for subsequent analysis.

Findings

The findings revealed a significant increase in the duration of microstate class D following stimulation in both groups, while microstate class C exhibited no notable changes. Additionally, a significant association was identified between the transition from microstate D to C and alterations in the State-Trait Anxiety Inventory-State (STAI-S) scores after left DLPFC stimulation.

Conclusion

Microstate map D appears to be associated with psychiatric disorders and executive functions, whereas map C may relate to the salience network and mind-wandering. Our findings suggest that microstate maps D and C are responsive to tDCS stimuli, indicating their potential as objective tools for anxiety assessment. Employing transition-focused parameters in EEG microstate analysis may enhance the tracking of rapidly fluctuating emotional states, rather than relying solely on duration metrics. Furthermore, the integration of non-invasive brain stimulation techniques, such as tDCS, with EEG microstate analysis holds significant promise for elucidating the neural mechanisms involved in depression.

Trial Registration

UMIN-CTR Clinical Trial: UMIN000015046

查看原文本刊更多论文

单次tDCS刺激可调节抑郁症患者与焦虑相关的脑电图微状态

目的微状态分析涉及脑电图（EEG）信号的时间动态，是探索精神疾病神经基础的重要方法。本研究探讨了经颅直流电刺激（tDCS）对抑郁症患者特定微状态参数图- d和C的影响，特别是针对背内侧前额叶皮层（DMPFC）和左背外侧前额叶皮层（DLPFC）。方法对19例临床诊断为抑郁症的患者进行了一项开放标签、受试者间、交叉试验。给予1ma电流，以阳极刺激专门针对DMPFC或左侧DLPFC。微状态图来源于静息状态脑电图记录，这些记录是在tDCS应用前后获得的。脑电图数据被分为五个不同的微状态类别，以供后续分析。结果显示，两组刺激后D级微状态持续时间均显著增加，而C级微状态无显著变化。此外，从微观状态D到C的转变与左DLPFC刺激后状态-特质焦虑量表-状态（STAI-S）评分的变化之间存在显著关联。结论微状态图D可能与精神障碍和执行功能有关，而微状态图C可能与显著性网络和走神有关。我们的研究结果表明，微状态图D和C对tDCS刺激有反应，表明它们有可能作为焦虑评估的客观工具。在脑电图微状态分析中采用以过渡为中心的参数可以增强对快速波动的情绪状态的跟踪，而不是仅仅依赖于持续时间指标。此外，将非侵入性脑刺激技术（如tDCS）与脑电图微状态分析相结合，对于阐明抑郁症的神经机制具有重要意义。试验注册UMIN-CTR临床试验：UMIN000015046

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

期刊介绍： Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)