Brain and Behavior最新文献

{"title":"Posterior Circulation Aneurysmal Subarachnoid Hemorrhage: A Comparison Between Saccular and Dissecting Aneurysms","authors":"Jian Li,&nbsp;Guoqiang Song,&nbsp;Guijing Liu,&nbsp;Yunyi Tong,&nbsp;Xinmiao Gu,&nbsp;Bangyue Wang,&nbsp;Libin Fan,&nbsp;Letian Li,&nbsp;Xinyu Yang,&nbsp;Honglei Liang,&nbsp;Xiaojun Zhang","doi":"10.1002/brb3.71668","DOIUrl":"10.1002/brb3.71668","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There is a lack of comparative studies between posterior circulation saccular aneurysms (SA) and dissecting aneurysms (DA). This study aims to comprehensively compare the clinical characteristics, treatment strategies, and outcomes of SA and DA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included all consecutive patients with posterior circulation aneurysmal subarachnoid hemorrhage (aSAH) who underwent surgical treatment between January 2017 and December 2020 from the Chinese Multicenter Cerebral Aneurysm Database (CMAD). Baseline data were retrospectively collected, and survival status and 2-year mRS scores were prospectively assessed. Functional outcomes were categorized as favorable (mRS 0–2) and unfavorable (mRS 3–6). Logistic regression models were used to explore the association between aneurysm morphology and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Note that 406 patients with posterior circulation aSAH who underwent surgical treatment were included, comprising 314 (77.3%) with SA and 92 (22.7%) with DA. In unadjusted analyses, DA was associated with a lower rate of unfavorable outcomes at 2 years (17.1% vs. 34.8%, <i>p</i> = 0.003) but a higher rate of parent vessel sacrifice (22.8% vs. 8.0%, <i>p</i> &lt; 0.001), while ischemic complications were comparable between groups. After further adjustment for covariates, DA showed a trend toward a lower risk of unfavorable outcomes in Model 3 (OR = 0.490, 95% CI 0.237–1.013, <i>p</i> = 0.054). In addition, the association between DA and a higher risk of parent vessel sacrifice remained consistent across all models (Model 1: OR = 3.419, 95% CI 1.811–6.456, <i>p</i> &lt; 0.001; Model 2: OR = 2.737, 95% CI 1.415–5.293, <i>p</i> = 0.003; Model 3: OR = 2.899, 95% CI 1.463–5.747, <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>DA may be associated with a trend toward better long-term functional outcomes compared with SA. Although parent vessel sacrifice was more frequently required, it was not associated with an increased risk of ischemic complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decalcified and Decellularized Bone Conduits for Peripheral Nerve Regeneration: A Comparative In Vivo Study Using Rat Femur and Chicken Ulna Conduits","authors":"Zahra Sepehri,&nbsp;Ali Moradi,&nbsp;Nasser Mahdavi-Shahri,&nbsp;Morteza Behnam Rassouli","doi":"10.1002/brb3.71546","DOIUrl":"10.1002/brb3.71546","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose:</h3>\u0000 \u0000 <p>Peripheral nerve injuries (PNIs) pose a major clinical challenge, especially when nerve gaps exceed 5 mm and spontaneous regeneration is inadequate. This study aimed to evaluate the regenerative potential of novel bone-derived nerve guidance conduits (NGCs) fabricated from rat femoral diaphysis and chicken ulna as alternatives to conventional autologous and allogeneic grafts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods:</h3>\u0000 \u0000 <p>Demineralized and decellularized bone scaffolds were characterized for collagen preservation, luminal geometry, and mechanical and electrical properties. In vivo, the conduits were implanted to bridge 10 mm sciatic nerve gaps in rats. Functional recovery was assessed over 16 weeks using sciatic functional index (SFI), hot-plate latency, and gastrocnemius muscle mass ratio. Histological analysis and RT-qPCR profiling of ECM-related genes (COL1A1, FN1, LAMB2, and Tenascin-C) were performed to evaluate tissue integration and molecular responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings:</h3>\u0000 \u0000 <p>Chicken-derived conduits showed superior tensile strength and elasticity, while both scaffold types supported hydration-dependent ionic conductivity. In vivo results demonstrated progressive conduit resorption and nerve tissue replacement. Treated groups showed significant motor and sensory recovery compared to axotomy controls. Histology revealed early axonal infiltration, neovascularization, and remyelination. Gene expression analysis indicated scaffold-specific temporal regulation aligned with regenerative phases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion:</h3>\u0000 \u0000 <p>Bone-derived NGCs from rat femur and chicken ulna effectively supported structural, electrophysiological, and functional nerve regeneration. These findings highlight their promise as accessible, biocompatible alternatives to traditional grafts and provide a foundation for future translational research in peripheral nerve repair.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Variability of Sodium and Potassium Predicts Mortality in Critically Ill Patients With Ischemic Stroke: Evidence From Two Critical Care Cohorts","authors":"Jian Zhang,&nbsp;Wei Zhang,&nbsp;Bin Zeng,&nbsp;Linfeng Xie,&nbsp;Jianjun Zhu","doi":"10.1002/brb3.71626","DOIUrl":"10.1002/brb3.71626","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ischemic stroke (IS) is one of the leading causes of death and long-term disability worldwide. Electrolyte fluctuations, particularly in sodium and potassium, may play a critical role in the mortality of IS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study utilized the MIMIC-IV database and NWICU to examine the association between sodium and potassium variability (coefficient of variation [CV]) and mortality in IS patients. A total of 3266 IS patients were included. The study focused on 30-, 90-, and 360-day all-cause mortality. Patients were stratified into quartiles based on CV values for sodium and potassium variability. Multivariable Cox proportional-hazards models were used to assess associations. Cumulative incidence was estimated using Kaplan–Meier methods. Restricted cubic spline (RCS) analyses were conducted to examine the associations of sodium and potassium CVs with the primary outcomes. Sensitivity analyses further examined the impact of electrolyte levels and variability on mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, 2593 patients from MIMIC-IV and 673 patients from NWICU were analyzed by sodium and potassium fluctuation quartiles. Sodium and potassium variability were significantly associated with mortality at 30-day, 90-day, and 360-day intervals, with continuous sodium variability showing HRs of 1.22 (30-day), 1.18 (90-day), and 1.17 (360-day), and Q4 significantly increasing risk (HR = 1.78, 1.51, 1.49, respectively). In NWICU, Q4 sodium variability was an independent risk factor for 30-day mortality (HR = 4.04, <i>p</i> &lt; 0.001). Sensitivity analyses confirmed that both high and low sodium and potassium levels were associated with increased mortality risks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Fluctuations in sodium and potassium levels were strongly linked to increased short-term and long-term mortality risk in intensive care unit (ICU) patients. Patients with high variability in both electrolytes had the worst prognosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Reserve and Psychological Well-Being in Aging Population of Community-Dwellers in Spain","authors":"Mikhail Ordin,&nbsp;Angel Barrasa,&nbsp;Caridad López-Granero,&nbsp;Leona Polyanskaya","doi":"10.1002/brb3.71714","DOIUrl":"10.1002/brb3.71714","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Greater brain resilience—the capacity of the brain to maintain normal functioning and cognition with aging—is associated with a slower cognitive decline. Cognitive reserve (CR) is one component of brain resilience and may be supported by educational, occupational, and leisure experiences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This exploratory, cross-sectional study examined associations among psychological well-being, engagement in leisure activities associated with cognitive reserve, and cognitive performance in older community dwellers (older adults living independently) in Spain. General brain resilience was tapped on by measuring performance in memory and attention cognitive tasks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We used the depression, anxiety and stress scale (DASS-21), life satisfaction scale (SWLS), loneliness scale (UCLA), and cognitive reserve scale (CRS) as proxy measures for psychological well-being and cognitive reserve in 80 people (33 men) between 65 and 101 years of age. The CRS was used as a proxy measure of the leisure-activity contribution to cognitive reserve rather than as a comprehensive or direct measure of cognitive reserve. To probe cognitive performance, we administered a memory-span task and spatial-cueing tasks measuring endogenous and exogenous attention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>Among males, higher CRS scores were associated with lower perceived stress and greater reported loneliness, whereas comparable associations were not observed among females. Higher CRS scores were also associated with selected measures of attention. No significant association was observed between CRS scores and memory span. Given the exploratory design and sample size, sex-specific findings should be interpreted cautiously.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We discuss these findings and outline a research agenda for more hypotheses-driven studies to investigate the intricate relationships among different aspects of brain resilience, psychological well-being and cognitive performance in older individuals. Better understanding of intricate associations between cognitive performance and psychological factors (feeling of loneliness, subjective stress and anxiety, and life satisfaction) may contribute to our understanding of how lifestyle and cognitive reserve are related.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of Decompressive Craniectomy in Severe Traumatic Brain Injury Patients: A Systematic Review of Economic Studies.","authors":"William Andrés Florez-Perdomo, Juan Sebastián Reyes Bello, Luis Rafael Moscote-Salazar, Vishal Chavda, Kashif Qureshi, Murtaja Satea, Claudia Restrepo, Amit Agrawal, Daniel Ant Encarnacion Santos, Mukhammadjon Norov, Norov Abdurakhmon, Bipin Chaurasia","doi":"10.1002/brb3.71748","DOIUrl":"10.1002/brb3.71748","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aimed to assess the cost-effectiveness of decompressive craniectomy (DC) in severe traumatic brain injury (TBI) patients by analyzing relevant economic studies.</p><p><strong>Methods: </strong>The authors conducted a comprehensive search across multiple databases and included economic evaluation studies, clinical trials, observational studies, or modeling studies that focused on patients who underwent DC for severe TBI. The quality of included studies was assessed using the Drummond checklist, and potential publication bias was examined. Data on total hospital costs, quality-adjusted life years (QALY), cost per QALY, and patient demographics were extracted and analyzed.</p><p><strong>Results: </strong>The included studies were of moderate to high quality. Total hospital costs increased with a higher likelihood of unfavorable outcomes. A cost-utility analysis demonstrated that DC led to a higher expected QALY gain compared to medical management. At 12 months, though, DC was the costlier option. In the Finnish cohort, the estimated cost of continued care ran to several times that of the initial admission, which raised the all-in cost per QALY well above the figure for neurosurgical treatment alone. Cost-effectiveness varied with the severity of TBI.</p><p><strong>Conclusions: </strong>DC may be cost-effective in the management of severe TBI in selected patients, particularly those at lower risk of an unfavorable outcome, although the available evidence is limited and heterogeneous. That value falls as injury severity rises, and at the extreme end of severity the procedure is no longer cost-effective. Decisions about DC in severe TBI therefore turn on both the expected clinical benefit and the cost, not on either alone. Longer follow-up would help, since much of both the cost and the recovery in these patients accrues years after surgery.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71748"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CSF Tau and Amyloid Biomarkers in Cognitive Impairment Across the ALS–FTD Spectrum: A Systematic Narrative Review and Evidence Map","authors":"Aasim Ali,&nbsp;Muhammad Arif,&nbsp;Usama Ashraf,&nbsp;Saad Elahi,&nbsp;Aswad Mustafa,&nbsp;Mahad Bin Yasir,&nbsp;Waqar Sarfraz,&nbsp;Asad Ullah Ansari,&nbsp;Hafiz Muhammad Yousaf Masood,&nbsp;Muhammad Asad Shabbir,&nbsp;Armaghana Abdullah,&nbsp;Mukesh Kumar Sharma","doi":"10.1002/brb3.71740","DOIUrl":"10.1002/brb3.71740","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Cognitive impairment is an important non-motor manifestation of amyotrophic lateral sclerosis (ALS), particularly across the ALS–frontotemporal dementia (ALS–FTD) spectrum. Cerebrospinal fluid (CSF) tau and amyloid biomarkers may reflect nonspecific neurodegenerative injury, concomitant Alzheimer disease (AD) pathology, or distinct cognitive phenotypes. However, available evidence remains limited, fragmented, and methodologically heterogeneous.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This systematic narrative review and semi-quantitative evidence map was conducted according to PRISMA 2020 recommendations. PubMed, Scopus, Web of Science, and Google Scholar were searched from database inception through May 2026. Eligible observational studies reported cognition-specific associations between CSF tau, amyloid, or related neurodegenerative biomarkers and cognitive outcomes in ALS-spectrum populations. Two reviewers independently screened studies, extracted quantitative effect estimates, and assessed risk of bias using the Newcastle–Ottawa Scale. Cross-study consistency was summarized using an exploratory semi-quantitative evidence-coding framework.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Four observational studies comprising 638 ALS-spectrum participants fulfilled the eligibility criteria. Total tau and p-tau181 showed the most reproducible associations with cognition. Total tau correlated with ECAS total (&lt;i&gt;r&lt;/i&gt; = −0.398, &lt;i&gt;P&lt;/i&gt; &lt; 0.001) and ALS-specific cognition (&lt;i&gt;r&lt;/i&gt; = −0.403, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), while adjusted multicenter analyses demonstrated associations between p-tau181 and ECAS total (&lt;i&gt;β&lt;/i&gt; = −0.03, &lt;i&gt;p&lt;/i&gt; = 0.006) and memory performance (&lt;i&gt;β&lt;/i&gt; = −0.04, &lt;i&gt;p&lt;/i&gt; = 0.003). Both biomarkers received ++ evidence-map coding. Amyloid findings were more heterogeneous; lower Aβ42/Aβ40 was associated with poorer memory performance (&lt;i&gt;β&lt;/i&gt; = 0.20, &lt;i&gt;p&lt;/i&gt; = 0.044), but continuous amyloid–cognition associations were not consistently replicated across cohorts (± evidence). Broader CSF protein-ratio findings remained exploratory. Clinical, cognitive, assay, and analytical heterogeneity precluded meta-analysis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The available evidence, although limited and heterogeneous, suggests that total tau may primarily reflect broader neurodegenerative injury, whereas p-tau181 and Aβ42/Aβ40 may be more informative for selected cognitive phenotypes or possible AD co-pathology. These biomarkers should remain research tools until larger, standardi","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial Activation Plays a Critical Role in LPS-Induced Contextual Fear Memory Consolidation Impairment and Blood-Brain Barrier Disruption.","authors":"Jun Zheng, Linxuan Li, Xinchun Jin, Wencao Liu","doi":"10.1002/brb3.71747","DOIUrl":"10.1002/brb3.71747","url":null,"abstract":"<p><strong>Background: </strong>Accurately predicting environmental dangers is a fundamental ability for animal and human survival. Fear memory could be disrupted by various stimuli, including inflammation, which can be mimicked by lipopolysaccharide (LPS) injection. LPS, which can activate microglia and disrupt the blood-brain barrier (BBB), can impair contextual fear memory consolidation when injected immediately after fear conditioning. However, the mechanism is not clear. Minocycline, a tetracycline derivative, can reduce inflammation and microglial activation. This study aims to explore the role of microglial activation in LPS-induced contextual fear memory consolidation impairment and BBB disruption.</p><p><strong>Methods: </strong>Immediately after the fear conditioning training, 0.5 or 1 mg/kg LPS was injected i.p., and the contextual fear memory was tested 24 h later, followed by biochemical and histological test.</p><p><strong>Results: </strong>The results showed that LPS impaired contextual fear memory consolidation, which was accompanied by a significant leakage of immunoglobulin G (IgG) in the hippocampus 24 h after LPS treatment. In addition, significantly decreased levels of claudin-5 and occludin, and significantly upregulated levels of caveolin-1, microglial activation, and the levels of pro-inflammatory factors interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were found in the hippocampus. In contrast, minocycline, which could inhibit microglial activation, reduce LPS-induced memory impairment and BBB damage.</p><p><strong>Conclusions: </strong>In summary, the study provides preliminary evidence that LPS can impair the consolidation of contextual fear memory by causing microglial activation, releasing pro-inflammatory factors IL-1β and TNF-α, and leading to BBB disruption in the hippocampus of mice.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71747"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intensive Blood Pressure Reduction on Perihematomal Edema After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.","authors":"Xianxian Li, Chengguang Zou, Yuchao Jia, Chensheng Pan, Xiaodong Ye, Suiqiang Zhu, Shanshan Huang","doi":"10.1002/brb3.71724","DOIUrl":"10.1002/brb3.71724","url":null,"abstract":"<p><strong>Background: </strong>Perihematomal edema (PHE) is a radiological marker of intracerebral hemorrhage (ICH)-induced secondary brain injury. Whether intensive blood pressure (BP) reduction attenuates PHE expansion remains uncertain. We conducted a systematic review and meta-analysis to assess the effect of intensive BP reduction on approximately 24-h PHE expansion in patients with spontaneous ICH.</p><p><strong>Methods: </strong>MEDLINE, Embase, and the Cochrane Library were searched from database inception to January 2026. Eligible studies compared intensive versus standard BP reduction in patients with spontaneous ICH and reported PHE-related outcomes. Risk of bias was assessed using the Cochrane risk-of-bias tool. Pooled estimates were calculated using the inverse-variance method with a fixed-effect model.</p><p><strong>Results: </strong>Six studies were included in the qualitative synthesis, and 4 studies were included in the quantitative meta-analysis, comprising 1061 patients in the intensive BP reduction group and 966 patients in the standard BP management group. Intensive BP reduction was associated with smaller approximately 24-h PHE expansion than standard BP management (mean difference, -0.50 mL; 95% CI, -0.89 to -0.12; p = 0.010). No statistical heterogeneity was observed (I² = 0%).</p><p><strong>Conclusions: </strong>Intensive BP reduction was associated with smaller approximately 24-h PHE expansion in patients with spontaneous ICH. Further standardized studies are needed to confirm the clinical relevance of this effect.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71724"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Emerging Trends and Hot Spots in Tauopathy Research (2003-2025): A Bibliometric Analysis\".","authors":"","doi":"10.1002/brb3.71778","DOIUrl":"10.1002/brb3.71778","url":null,"abstract":"","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71778"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Associations Between Sedentary Time and Sleep Traits.","authors":"Haobin Huang, Lei Zheng, Chunyu Zhong, Zhixi Lu, Guoxi Li, Cheng Xu, Hong Cai, Guangfeng Long","doi":"10.1002/brb3.71776","DOIUrl":"10.1002/brb3.71776","url":null,"abstract":"<p><strong>Background: </strong>Few observational studies have examined relationships between sedentary time and sleep traits, and their causal relationships remain unexplored in the general population.</p><p><strong>Methods: </strong>We triangulated evidence using observational analyses and one-sample Mendelian randomization (MR) in the UK Biobank. Sedentary time was assessed by self-report and wrist-worn accelerometry (accelerometer substudy). Six sleep traits were examined: evening chronotype, difficulty waking up, insomnia, short sleep (< 6 h), long sleep (> 9 h), and snoring. Observational associations were estimated using logistic regression with stepwise adjustment, and exploratory observational mediation analyses evaluated BMI as a potential mediator. MR used a genetic risk score for sedentary time and included primary linear MR and secondary nonlinear MR to test departures from linearity. Statistical significance for the six prespecified outcomes in primary linear MR was evaluated using a Bonferroni correction (p < 0.05/6 = 8.3 × 10^- ³).</p><p><strong>Results: </strong>In linear MR, higher genetically predicted sedentary time was associated with increased odds of insomnia, short sleep, long sleep, and snoring, and these associations remained significant under the Bonferroni-corrected threshold. Nonlinear MR provided no robust evidence of departure from linearity after accounting for multiple testing. In observational analyses, self-reported sedentary time was associated with multiple adverse sleep traits. In accelerometer-based analyses, device-measured sedentary time was positively associated with short sleep and evening chronotype, inversely associated with insomnia and long sleep, and its association with snoring was attenuated toward null after full adjustment. Exploratory observational mediation models suggested that BMI may account for part of several associations, particularly that with snoring; these estimates do not establish a causal pathway.</p><p><strong>Conclusion: </strong>Higher sedentary time may be detrimental to sleep health, with the strongest evidence for short sleep across complementary methods. For other sleep traits, methodological heterogeneity warrants cautious interpretation and further validation.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"16 9","pages":"e71776"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}