Brain and Behavior最新文献

{"title":"A Mendelian Randomization Study and Experimental Validation Investigating the Potential Relationship Among Interleukin-6 Receptor Subunit Beta, Obesity, and Alzheimer's Disease","authors":"Yu Liu,&nbsp;Nan Song,&nbsp;Qun Wang,&nbsp;Peng Cui,&nbsp;Dongyu Min","doi":"10.1002/brb3.70772","DOIUrl":"10.1002/brb3.70772","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study employs Mendelian randomization (MR) aimed at systematically evaluating the relationship among interleukin-6 receptor subunit beta, obesity, and Alzheimer's disease (AD). We conducted animal studies to validate the reliability of the MR analytical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The pooled data for the interleukin-6 receptor subunit beta originated from the genome-wide association study (GWAS) dataset, which included a total of 10,534,735 participants. Obesity pooled data were from the GWAS dataset (case <i>n</i> = 23,971 and control <i>n</i> = 388,084) and AD pooled data from the GWAS database (case <i>n</i> = 39,106 and control <i>n</i> = 46,828). The aforementioned data sets facilitated MR causal analysis. First, utilize the inverse variance weighting (IVW) method for analysis and enhance it with MR-Egger regression and weighted median approaches, and a sensitivity analysis was performed by MR-multiple effect residuals and outliers (MR-Presso), Cochran Q test, and Leave-one (LOO) analysis. We established an obesity model by feeding 6-week-old male ApoE^−/− mice a high-fat diet for 16 weeks. In contrast, C57BL/6 control mice were fed a normal diet for the same duration. An AD model was established by feeding 3-month-old APP/PS1 mice a normal diet for 24 weeks. We harvested serum and hippocampal tissue from the mice for enzyme-linked immunosorbent assay (ELISA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MR analysis indicated that a genetically predicted increase in interleukin-6 receptor subunit beta raises the risk of AD (OR = 1.064, 95% CI: 1.021–1.109, <i>p</i> = 0.003). The exposure factor interleukin-6 receptor subunit beta served as a protective element against obesity (OR = 0.9372,95%CI:0.8921–0.9847, <i>p</i> = 0.010). Obesity showed an adverse relationship with AD. As the body mass index (BMI) increased, the risk of developing AD decreased (OR = 0.9299, 95% CI: 0.8939–0.9674, <i>p</i> ＜0.001). ELISA findings revealed that the levels of interleukin-6 receptor subunit beta (gp130), oncostatin-M (OSM), and IL-6 in serum and hippocampus decreased in obesity, whereas they increased in AD, aligning with the results of the MR Analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In summary, our extensive Mendelian randomization data suggest that increased levels of the interleukin-6 receptor subunit beta may be associated with a reduced risk of obesity, and consequently, may increase the risk of AD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization and Machine Learning Reveal Immune Cell and Gene Drivers in Systemic Lupus Erythematosus","authors":"Luofei Huang,&nbsp;Jian shi,&nbsp;Han Li,&nbsp;Quanzhi Lin","doi":"10.1002/brb3.70754","DOIUrl":"10.1002/brb3.70754","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unclear pathogenesis. Recent studies suggest that immune cell phenotypes may play a causal role. This study aimed to uncover causal immune cell types, key genes, and potential biomarkers using Mendelian randomization (MR) and machine learning.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A two-sample MR analysis was performed on 731 immune cell traits to assess their causal relationship with SLE risk. Gene Expression Omnibus datasets were used to identify differentially expressed genes (DEGs), followed by immune infiltration analysis and machine learning-based gene selection. Key genes were validated using independent datasets and expression quantitative trait loci-MR analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant causal links with SLE were observed for 10 immune cell subtypes (<i>p</i> &lt; 0.01). A total of 17 DEGs, including FCGR2A, TMEM181, and RASA3, were identified as being associated with immune infiltration. Single-sample gene set enrichment analysis revealed altered immune cell compositions in SLE. Five key genes (FCGR2A, TMEM181, RASA3, BCAR3, and MCTP2) with strong diagnostic potential (area under the curve = 0.948) were identified using a support vector machine model. Their causal relevance was confirmed by MR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This integrative approach revealed 10 immune cell types and five genes with causal roles in SLE, offering novel insights into disease mechanisms and potential targets for precision medicine.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive Symptoms Profiles and Cognitive Outcomes After Stroke","authors":"Giuseppe Scopelliti,&nbsp;Francesco Mele,&nbsp;Ilaria Cova,&nbsp;Federico Masserini,&nbsp;Valentina Cucumo,&nbsp;Giorgia Maestri,&nbsp;Alessia Nicotra,&nbsp;Arianna Forgione,&nbsp;Pierluigi Bertora,&nbsp;Simone Pomati,&nbsp;Emilia Salvadori,&nbsp;Leonardo Pantoni","doi":"10.1002/brb3.70801","DOIUrl":"https://doi.org/10.1002/brb3.70801","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Post-stroke depressive symptoms are heterogeneous and variably associated with other psycho-cognitive features. We employed cluster analysis to identify distinct profiles of post-stroke depressive symptomatology and their association with cognitive performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included consecutive patients undergoing neuropsychiatric evaluation 6 months after stroke. Cluster analysis incorporated the Center for Epidemiologic Studies Depression Scale, along with the apathy and anxiety items from the Neuropsychiatric Inventory questionnaire. Baseline clinical/neuroimaging variables and 6-months cognitive outcomes were compared across profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 189 patients with acute cerebrovascular events (median age 75.4 years, 62% male, 80% ischemic strokes). Three profiles emerged: (A) low-depressive symptoms (<i>n</i> = 108), (B) moderate-depressive symptoms plus anxiety (<i>n</i> = 41), (C) high-depressive symptoms plus apathy (<i>n</i> = 40). Regarding baseline predictors of 6-month depressive symptoms profiles, patients with high-depressive symptoms plus apathy exhibited lower Montreal Cognitive Assessment scores at baseline (16.0 vs. 21.5; adjusted odds ratio [adj.OR] per 1-point increase 0.91, 95% confidence interval [95% CI] 0.83–0.99) compared to patients with low-depressive symptoms; moderate-depressive symptoms plus anxiety patients had less cortical atrophy compared to both low-depressive symptoms (adj.OR 0.92, 95% CI 0.86–0.99) and high-depressive symptoms plus apathy (adj.OR 0.89, 95% CI 0.81–0.97) profiles. Regarding 6-month cognitive performance, high-depressive symptoms plus apathy patients showed higher rates of post-stroke dementia and attention/executive function impairment compared with the two other groups (both <i>p</i> &lt; 0.05), and higher rates of language impairment compared with low-depressive symptoms profile (<i>p </i>&lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>By integrating apathy and anxiety in our model, depressive symptoms after stroke emerged as heterogeneous neuropsychiatric syndromes, showing different baseline predictors and distinctive cognitive patterns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70801","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory EEG Comparison of Good and Bad Readers","authors":"María José Álvarez-Alonso,&nbsp;Cristina de-la-Peña Álvarez,&nbsp;Ricardo Scott","doi":"10.1002/brb3.70780","DOIUrl":"https://doi.org/10.1002/brb3.70780","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study investigates the neurophysiological differences between proficient and struggling readers using electroencephalography (EEG).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Eighteen participants, categorized as good or poor readers based on standardized assessments, underwent resting-state EEG recordings. The analysis focused on the alpha (8–12 Hz) and beta (13–30 Hz) frequency bands, which are crucial for cognitive and language processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>Good readers exhibited increased beta power in frontal regions and enhanced synchronization within fronto-central-parietal networks compared to poor readers. Alpha band activity showed complex associations with age, reading skills, and verbal fluency. The heightened beta activity in good readers aligns with its role in cognitive control and language processing, while stronger network connectivity suggests more efficient neural communication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings provide insights into the neural basis of reading proficiency, highlighting the importance of distributed brain networks in skilled reading. Future research should replicate these results with larger samples and longitudinal designs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70780","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling","authors":"Hui-Hui Guo,&nbsp;Jun-Jie Liang,&nbsp;Rui-Huan Pan,&nbsp;Mei-Feng Zheng,&nbsp;Ya-Xian Qiu,&nbsp;Shan-Shan Jiang,&nbsp;Xin-Yu Fu,&nbsp;Hector Wing-Hong Tsang,&nbsp;Suk-Yu Yau,&nbsp;Hai-Ning Ou","doi":"10.1002/brb3.70767","DOIUrl":"https://doi.org/10.1002/brb3.70767","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cognitive impairment is one of the main complications after a stroke and seriously affects the quality of life and survival time of patients, thereby causing a heavy burden on the social economy and public health. Although exercise is an effective non-pharmacological strategy for prevention and treatment of cognitive impairment, the mechanism(s) of this effect remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The current study investigated the effects of irisin treatment on the behavioral characteristics of mice with post-stroke cognitive impairment (PSCI). The expression levels of platelet endothelial cell adhesion molecule 1 (PECAM, PECAM-1, CD31), glial fibrillary acidic protein (GFAP), vascular endothelial growth factor (VEGF), and molecules in the adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK)–endothelial nitric oxide synthase (eNOS) signaling cascade in the hippocampus were then measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Irisin significantly enhances learning and memory functions in cases of PSCI. This improvement correlates with a reduction in cerebral infarction size and decreased neuronal death. Additionally, irisin treatment resulted in a marked decrease in the levels of astrocytic scar formation in the cortex. Furthermore, irisin activates the AMPK-eNOS signaling pathway, which promotes the expression of VEGF. The irisin compounds are involved in the process of brain angiogenesis and play a critical role in endothelial and reactive astrocytes function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study revealed a potential mechanism by which exercise-induced irisin secretion may attenuate PSCI. Irisin improved endothelial dysfunction and neuroinflammation, suggesting it may be a promising target for PSCI therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70767","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL7R+ T Cell-Macrophage Crosstalk Links Asthma to Alzheimer's Pathogenesis: Integrating Mendelian Randomization and CellChat Analysis","authors":"Jing Yang,&nbsp;Zixing Liu,&nbsp;Xiaofang Li,&nbsp;Yichong Qiu,&nbsp;Qiong Liu,&nbsp;Xiufang Huang,&nbsp;Leshen Lian","doi":"10.1002/brb3.70809","DOIUrl":"https://doi.org/10.1002/brb3.70809","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Epidemiological investigation has revealed a higher incidence of Alzheimer's disease (AD) in individuals with severe asthma. However, the causality of this relationship remains uncertain. The current research aimed to examine the potential link between genetically predicted moderate to severe asthma and the risk of AD using Mendelian randomization (MR) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Summary statistics obtained from genome-wide association studies of AD (<i>n</i> = 455,258) and moderate to severe asthma (<i>n</i> = 57,695) in individuals of European ancestry were utilized in this MR study. SMR analysis was also performed to investigate whether the expression of these genes was correlated with AD or moderate to severe asthma outcomes to detect a causal relationship between moderate to severe asthma and AD. Genome-wide genetic correlation between moderate to severe asthma and AD was estimated using linkage disequilibrium score regression (LDSC). Single-cell RNA sequencing (scRNA-seq) datasets of asthma-related peripheral blood mononuclear cell (PBMC) data and AD cerebrospinal fluid (CSF) were obtained to further investigate the crosstalk between the different biological pathways in asthma and AD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The impact of moderate to severe asthma on AD risk persisted (OR_IVW= 1.01, 95% CI = 1.00–1.02, <i>p</i> = 3.85 × 10⁻³) after controlling for confounder risk factors in multivariable MR analyses. Additionally, the study showed that 1.8% of the total effect (moderate to severe asthma) was mediated by eosinophils. SMR analysis and the gene-wide MR analysis revealed numerous gene targets linked to the susceptibility of AD and moderate to severe asthma. Among these targets, FPR1 (Formyl Peptide Receptor 1), IL1RAP (Interleukin 1 Receptor Accessory Protein), IL7R (Interleukin 7 Receptor), and IL18RAP (Interleukin 18 Receptor Accessory Protein) warrant additional exploration as potential therapeutic targets for AD and moderate to severe asthma. LDSC analysis revealed no significant overlap between asthma and AD (rg = 0.0436, SE = 0.0813, <i>p</i> = 0.592), suggesting distinct genetic architectures. Integrated single-cell RNA sequencing analysis of asthma PBMCs and AD CSF revealed IL7R may utilize the MIF-CD74-CXCR4 pathway to complete crosstalk between CD4 T cells and macrophages and contribute to AD disease development.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Probiotics Lactobacillus rhamnosus DM163 and Lactobacillus delbrueckii DPUL-F36 on Anxiety-Related and Emotional Behaviors in Male Wistar Rats Under an Altered Light–Dark Cycle","authors":"Farnaz Ghayour Babaei,&nbsp;Ali Moghimi,&nbsp;Ehsan Saburi,&nbsp;Ali Makhdoumi,&nbsp;Morteza Behnam Rasouli","doi":"10.1002/brb3.70814","DOIUrl":"10.1002/brb3.70814","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Anxiety and stress are prevalent mental health issues. Traditional drug treatments often come with unwanted side effects and may not produce the desired results. As an alternative, probiotics are being used as a treatment option due to their lack of specific side effects. Probiotics are live microorganisms that, in sufficient amounts, benefit the host's health. The human digestive tract naturally contains hundreds of different types of bacteria; among these bacteria, probiotic strains of <i>Lactobacillus rhamnosus</i> DM163 and <i>Lactobacillus delbrueckii</i> DPUL-F36 are among the species that may improve behavioral disorders such as anxiety and stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, 42 adult male Wistar rats (190–220 gr/BW), categorized into six groups, were used. Except for the control group, the rest were subjected to 30 days of light–dark cycle alteration (4 h dark, 20 h light). Simultaneously with the light/dark disruption, these groups were gavaged daily doses of 1 × 10⁹ colony-forming units (CFU) of the target probiotics. Stool samples were collected to confirm changes in the gut microbiota before and after administration of probiotics. Following DNA extraction, PCR was performed using specific primers. The open-field test and the elevated plus maze test were used to check the anxiety, stress, and exploratory behaviors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The comparison of behavioral tests showed that the change in the light–dark cycle caused negative behavioral changes, and the administration of probiotics, particularly <i>L. rhamnosus</i>, was found to be more effective in reducing anxiety and stress levels and improving exploratory behavior compared to <i>L. delbrueckii</i>. The qualitative PCR test also determined that during the 30-day intervention period, <i>L. rhamnosus</i> and <i>L. delbrueckii</i> bacteria were present in the intestinal bacterial flora of rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Changes in the light–dark cycle cause significant disturbances in normal physiology. These alterations are especially evident in the functions of the central nervous system and various behaviors. So, in the long term, it can seriously lead to destructive neurodegenerative alterations of the nervous system. Probably, the increase and predominance of the population of probiotics and the effects of their metabolites using the gut–brain axis will lead to beneficial and even preventive effects.</p>\u0000 </section>\u0000 </d","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70814","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tafamidis Meglumine on Transient Focal Neurological Episodes and Meningeal Contrast Enhancement in Hereditary Transthyretin-Related Meningeal Amyloidosis: Report of Two Patients Carrying the c.265T>C (p.Y89H) Variant","authors":"Natsumi Saito,&nbsp;Yasuko Kuroha,&nbsp;Ayaka Ishiyama,&nbsp;Takahiro Wakasugi,&nbsp;Takayoshi Tokutake,&nbsp;Arika Hasegawa,&nbsp;Tetsuya Takahashi","doi":"10.1002/brb3.70856","DOIUrl":"10.1002/brb3.70856","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Y69H (p.Y89H) variant hereditary transthyretin (ATTRv) amyloidosis causes meningeal amyloidosis, with mutant TTR deposits localized to the leptomeninges and vitreous body.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The effect of tafamidis meglumine on neurological disorders, such as the frequency of transient focal neurological episodes (TFNEs), magnetic resonance imaging (MRI) findings, and TTR levels in cerebrospinal fluid, was investigated in two patients diagnosed with Y69H ATTRv mutation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The initial symptoms in both patients were TFNEs, such as aphasia, sensory disturbance, motor paralysis, ataxia, and drop attacks. Neither epileptic drugs nor antiplatelet therapy decreased the frequency of attacks. The patients exhibited diffuse leptomeningeal enhancement on brain and spinal MRI. Tafamidis meglumine was initiated at a dose of 20 mg/day and was found to be partially effective. The TFNEs nearly resolved, and meningeal enhancement on brain MRI improved; however, the neurological deficits progressed over the following 2 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Tafamidis had a partial effect on TFNEs and meningeal contrast enhancement on MRI; however, cerebellar ataxia and cognitive decline continued to progress.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Association Analysis of Anxiety and Psoriasis: Based on the NHANES Database","authors":"Jie Bai,&nbsp;Yan Ma","doi":"10.1002/brb3.70817","DOIUrl":"10.1002/brb3.70817","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background:&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Psoriasis is linked with an elevated risk of anxiety disorders, and there may be a temporal relationship between the two. However, the association between anxiety status and its duration with psoriasis is unclear.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The present work aimed to figure out the association between anxiety and the risk of psoriasis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Data from the National Health and Nutrition Examination Survey (NHANES) 2009–2012 were used. Anxiety state and days of anxiety were applied as the independent variables, and psoriasis as the dependent variable. Weighted logistic regression was employed to analyze the connection between the state and days of anxiety with psoriasis. Restricted cubic spline (RCS) was further utilized to dig out the nonlinear association between days of anxiety and psoriasis. By using weighted logistic regression to further explore the correlation between the combination of anxiety and common cardiovascular risk factors (smoking, hypertension, CVD events) and the risk of psoriasis. Finally, a weighted logistic regression model was constructed for different genders and alcohol consumption subgroups to explore the association between anxiety status and anxiety days and psoriasis and to evaluate the differences in association among different groups.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 8888 participants were included in this project, among whom 265 cases (3.1%) were psoriasis patients. Through the weighted logistics regression model, we observed a significant positive correlation between anxiety (OR: 1.439, 95% CI: 1.008–2.053, &lt;i&gt;p &lt;/i&gt;= 0.030), number of days with anxiety (OR: 1.018, 95% CI: 1.002–1.033, &lt;i&gt;p &lt;/i&gt;= 0.014), and the risk of psoriasis in patients. The RCS curve results indicated a linear positive correlation between anxiety days and the risk of psoriasis (&lt;i&gt;p&lt;/i&gt;-nonlinear = 0.162). The results of the joint analysis demonstrated that anxiety&lt;sup&gt;−&lt;/sup&gt;/smoking&lt;sup&gt;+&lt;/sup&gt; (OR: 1.800, 95% CI: 1.160–2.800, &lt;i&gt;p &lt;/i&gt;= 0.011), anxiety&lt;sup&gt;+&lt;/sup&gt;/smoking&lt;sup&gt;+&lt;/sup&gt; (OR: 2.720, 95% CI: 1.430–5.190, &lt;i&gt;p &lt;/i&gt;= 0.004), anxiety&lt;sup&gt;+&lt;/sup&gt;/hypertension&lt;sup&gt;+&lt;/sup&gt; (OR: 2.010, 95% CI: 1.200–3.370, &lt;i&gt;p &lt;/i&gt;= 0.011), anxiety&lt;sup&gt;−&lt;/sup&gt;/CVD event&lt;sup&gt;+&lt;/sup&gt; (OR: 1.740, 95% CI: 1.080–2.820, &lt;i&gt;p &lt;/i&gt;= 0.026), and anxiety&lt;sup&gt;+&lt;/sup&gt;/CVD event&lt;sup&gt;−&lt;/sup&gt; (OR:1.470, 95% CI: 1.000–2.150, &lt;i&gt;p &lt;/i&gt;= 0.047) were linked with a significantly elevated risk of psoriasis. The subgroup analysis results showed that w","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Treadmill Exercise and Voluntary Running Pre-Training Attenuates Vascular Dementia-Related Pathology by Regulating Hippocampal Structural Synaptic Plasticity in a Rat Model","authors":"Yujiao Li,&nbsp;Yuxuan Li,&nbsp;Linlin Zhang,&nbsp;Kunxia Su","doi":"10.1002/brb3.70833","DOIUrl":"10.1002/brb3.70833","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Clinical and basic research suggests that exercise is a safe behavioral intervention and effective in improving cognition in vascular dementia (VD). However, despite global efforts, there is still no effective method to completely cure VD. This study aimed to investigate the effects of long-term exercise pretreatment on typical VD pathology in a rat model, and further compare the neuroprotective impacts of different exercise modalities on VD rats.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Forty-eight SD adult male rats (200–240 g) were randomly allocated to a control group (Con, n = 12), a vascular dementia group (VD, n = 12), and a treadmill exercise and vascular dementia group (Tre-VD, n = 12), a voluntary running and vascular dementia group (Vol-VD, n = 12). Aerobic exercise training included treadmill exercise in the Tre-VD rats, and voluntary running in the Vol-VD rats, respectively. The bilateral common carotid artery occlusion operation was performed to induce the VD rat model in all groups except the Con group. Rat behavior, anxious-depressive-like behavior and cognition, was tested by the sucrose preference test, the open field test, the novel object recognition test, and the Y-maze and passive avoidance test. Brain microdialysis combined with a high-performance liquid chromatography (HPLC) system was applied to measure neurotransmitter concentrations in hippocampal extracellular fluid, including epinephrine (E), norepinephrine (NE), and dopamine (DA). Immunofluorescent staining was conducted to measure neuronal apoptosis. Transmission electron microscope was carried out to analyze hippocampal synaptic ultrastructure.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The behavioral results also showed that long-term treatment and voluntary pretreatment significantly alleviated cognitive impairment and anxious-depressive-like behaviors in VD rats (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Meanwhile, compared to the Con rat, VD rats had significantly decreased E NE, DA, and 5-HT (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), while exercise significantly increased those neurotransmitter levels in the hippocampus (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Moreover, neuronal apoptosis was found in the VD rat when comparing with the Con group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), conversely, exercise pretreatment effectively alleviated VD-induced neuronal apoptosis (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). In addition, the results of TEM revealed a significant reduction in hippocampal synapse numbers and postsynaptic density as well as the width of the synaptic cleft in VD rats compared to the Con (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), which was reversed by eight weeks of exercise pretreatment (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Intrigui","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 9","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70833","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}