Brain and Behavior最新文献

{"title":"Life Beyond Childhood: Insight Into the Lived Experience of 91 Adults With KBG Syndrome Through an Online Patient/Caregiver-Reported Co-Produced Questionnaire","authors":"Karen J. Low,&nbsp;Moira Walker,&nbsp;Georgia Treneman-Evans,&nbsp;Nuria C. Bramswig,&nbsp;Morten K. Herlin,&nbsp;Gaetan Lesca,&nbsp;Emanuela Scarano,&nbsp;Charlotte W. Ockeloen,&nbsp;Allan Bayat","doi":"10.1002/brb3.70553","DOIUrl":"https://doi.org/10.1002/brb3.70553","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>KBG syndrome (KBGS) is a rare neurodevelopmental syndrome. We aimed to study the impact of KBGS in adulthood as reported by individuals with KBGS and their families/caregivers, thereby exploring aspects of everyday life underreported by healthcare professionals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We co-produced an online questionnaire for adults with KBGS and their families/caregivers. Participants were recruited via the KBG Foundation, an American-based charity supporting individuals with KBGS and their families worldwide, and other international collaborators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 91 responses for analysis, across the age range of 16–86 years. Respondents described a range of living arrangements, education, employment, leisure activities, and relationships. A higher proportion of 45–54year-olds had achieved independent living skills such as driving and grocery shopping compared to the younger age groups. None of the participants who were experiencing seizures lived independently. We described high rates of psychiatric comorbidities, behavioral difficulties, sleep problems, seizures, visual and hearing problems, dental and skeletal issues, and a higher than expected cardiovascular and gastrointestinal burden of disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides new insights into the everyday life of adults with KBGS, along with high rates of comorbidities that continue to impact quality of life into adulthood, with implications for medical care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide-Induced Mouse Model of Depression","authors":"Wen-Wen Li,&nbsp;Rui Xiao,&nbsp;Xue-Yi Chen,&nbsp;Jun-Cai Pu,&nbsp;Jian-Jun Chen,&nbsp;Hai-Yang Wang,&nbsp;Lan-Xiang Liu,&nbsp;Dan Li,&nbsp;Yang-Dong Zhang,&nbsp;Wen-Xia Li,&nbsp;Peng Xie","doi":"10.1002/brb3.70549","DOIUrl":"https://doi.org/10.1002/brb3.70549","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Depression is a global health concern characterized by high incidence, disability, and disease burden. Neuroimmunity, through the secretion of inflammatory mediators and mediation of neuroinflammation, plays a significant role in depression's pathogenesis. However, the underlying molecular mechanisms remain poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this pioneering study, we employed a comprehensive multi-omics approach, integrating 2-DE proteomics, liquid chromatography mass spectrometry-based metabolomics, and real-time polymerase chain reaction (PCR) array, to investigate the hippocampal molecular profiles of lipopolysaccharide (LPS)-induced immune inflammation-related depression. This innovative approach aimed to explore the potential pathogenesis of depression by systematically integrating data across multiple molecular layers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to the control group, we identified 81 differential proteins, 44 differential metabolites, and 4 differential mRNAs in LPS-treated mice. Integrated analysis of these multidimensional data revealed that purine metabolism and glutamate metabolism are the most significantly altered molecular pathways in LPS-induced depression. Additionally, we constructed the corresponding compound-reaction-enzyme-gene regulatory network.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests that purine metabolism and glutamate metabolism may be the underlying mechanisms by which neuroinflammation regulates depression-like behaviors. Our findings confirm the important role of immune inflammation in depression and provide a new clue for the diagnosis and treatment of this disorder. Notably, the multi-omics approach employed in this study represents a pioneering effort in the field, providing unprecedented insights into the molecular mechanisms underlying depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Protection Against Status Epilepticus Caused by Lithium–Pilocarpine: Combination of Midazolam and Lacosamide","authors":"Cumaali Demirtas,&nbsp;Metehan Akca,&nbsp;Ugur Aykin,&nbsp;Yunus Emre Surmeneli,&nbsp;Hava Yildirim,&nbsp;Mehmet Yildirim","doi":"10.1002/brb3.70546","DOIUrl":"https://doi.org/10.1002/brb3.70546","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Status epilepticus causes the most severe condition related to epilepsy in terms of high mortality rate. Although status epilepticus treatment guidelines specify a treatment process based on three-stage monotherapy, effective control cannot yet be achieved in all cases. In the presented study, with electrophysiological and behavioral tests, it was aimed to investigate the effectiveness of the combination of midazolam (MDZ), one of the most commonly used benzodiazepines in the first-line treatment of status epilepticus, with the second-line antiepileptics levetiracetam (LEV), lacosamide (LCM), valproic acid (VPA), and fosphenytoin (fPHT).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A status epilepticus model was created with lithium–pilocarpine (5 mEq/kg–320 mg/kg) in adult male Sprague–Dawley rats with implanted electroencephalography (EEG) electrodes. MDZ (9 mg/kg) alone or in dual combinations with antiepileptic drugs (200 mg/kg LEV, 50 mg/kg LCM, 300 mg/kg VPA, 100 mg/kg fPHT) was injected i.p. to the experiment groups with status epilepticus. After video-EEG recordings were taken from the rats during and after status, the effects of drug interactions on cognitive and motor behaviors were examined by applying behavioral tests (open field, Rotarod, radial arm maze, and passive avoidance).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Compared with the untreated status epilepticus group, it was determined that MDZ alone and the combination of four antiepileptic drugs administered with MDZ significantly reduced the mortality rate, spike frequency, and spike amplitude of epileptic seizures and suppressed epileptic seizures at certain levels (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). Compared to MDZ monotherapy, it was determined that the mortality rate and spike frequency and amplitude decreased significantly in the MDZ + LCM group (&lt;i&gt;p&lt;/i&gt; &lt; 0.01), whereas on the other hand, mortality and spike frequency increased in the MDZ + LEV group (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). No negative effects were observed in learning and memory in all treatment groups, but it was determined that the motor functions of the animals treated with MDZ + fPHT were impaired compared to both the control group without any treatment and the MDZ group (&lt;i&gt;p&lt;/i&gt; &lt; 0.01).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In the status epilepticus model induced by lithium–pilocarpine, the combination of MDZ + LCM was found to be the most effective polytherapy option in reducing seizures and mortality. Additionally, it was observed that LEV, LCM, and VPA administered togeth","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationship Between Excessive Social Media Use and Eating Disorders Among Young Adults: Evidence From a Bangladesh-Based Cross-Sectional Study","authors":"Trisha Mallick,&nbsp;Md. Hasan Al Banna,&nbsp;Tasnim Rahman Disu,&nbsp;Shammy Akter,&nbsp;Tareq Mahmud,&nbsp;Tasnima Akhter Tasin,&nbsp;Nargees Akter,&nbsp;Md. Saiful Alam,&nbsp;Md. Nazmul Hassan","doi":"10.1002/brb3.70540","DOIUrl":"https://doi.org/10.1002/brb3.70540","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Problematic or addictive use of social media has been associated with psychological and health issues. The main objective of this study was to explore the relationship between Facebook addiction and eating disorders (EDs) among young adults in Bangladesh.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted an online-based cross-sectional study among 550 young adults aged 18 to 27 in Bangladesh. A structured questionnaire was used to obtain the survey data. The survey tool consisted of three sections: (i) socio-demographic, behavioral, and social media use-related characteristics, (ii) assessment of Facebook addiction using Bergen Facebook Addiction Scale, and (iii) assessment of EDs risk using Eating Attitudes Test-26 (EAT-26, outcome variable). Scoring at or above 20 on the EAT-26 scale (total score ranges from 0 to 78) indicated an ED risk. Unadjusted and adjusted binary logistic regression analyses were performed to investigate the relationship outcome and explanatory variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Approximately 38% of the study participants showed addiction to Facebook, whereas 23.6% were at risk of developing an ED. Multiple adjusted logistic regression models demonstrated that Facebook addiction was significantly associated with an increased risk of EDs (OR  =  1.784; 95% confidence interval [CI]: 1.154–2.760). Moreover, smoking habits, self-rated body mass index (BMI), and physical activity level showed a significant association with the risk of EDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings may help public health professionals and policymakers to take the initiative and develop strategies to overcome these addictive behaviors and promote healthy eating habits across the country.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Combining Transcranial Direct Current Stimulation and Pain Neuroscience Education in Patients With Chronic Low Back Pain and High Pain Catastrophizing: An Exploratory Clinical, Cognitive, and fMRI Study","authors":"Cory Alcon,&nbsp;Sarah Margerison,&nbsp;Haley Kirse,&nbsp;Christopher Zoch,&nbsp;Paul Laurienti,&nbsp;David Seminowicz,&nbsp;Sharon Wang-Price","doi":"10.1002/brb3.70543","DOIUrl":"https://doi.org/10.1002/brb3.70543","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives:</h3>\u0000 \u0000 <p>Priming the neural circuitry likely targeted by pain neuroscience education (PNE) using transcranial direct current stimulation (tDCS) may enhance the efficacy of PNE. This exploratory study aimed to examine the effects of combining tDCS and PNE in those with chronic low back pain (CLBP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Six participants experiencing CLBP completed the study. Assessments for pain catastrophizing, kinesiophobia, pressure pain thresholds (PPT), pain intensity, cognitive function, and resting state and task fMRI were collected before and after the combined tDCS and PNE intervention. Each participant received five 20-min sessions of 2.0 mA tDCS targeting the left dorsolateral prefrontal cortex (DLPFC), followed by a 20-min PNE session.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The participants had a 58.9% reduction in pain catastrophizing, a 25.9% reduction in kinesiophobia, and an 18.8% improvement in cognitive function (i.e., reduced attentional interference). The MRI results indicated increased gray matter volume within the left DLPFC. Additionally, larger reductions in DLPFC activity at rest were associated with larger reductions in kinesiophobia. Increased modularity within networks responsible for cognitive control and executive functions was evident following the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Our clinical and fMRI outcomes shed light on the clinical potential of combining tDCS and PNE, as well as the mechanisms substantiating their effects. We speculate that tDCS alters brain activity and structure, amplifies the effects of PNE, and promotes positive changes in the cognitive-evaluative and sensory-discriminative pain domains investigated. A randomized controlled trial is warranted to determine the effects of tDCS combined with PNE compared with tDCS or PNE alone.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safflower Yellow Pigment Alleviates Cerebral Ischemia-Reperfusion Injury via Protein Nitration and Oxidative Modulation","authors":"Kun Wang,&nbsp;Xi Zhang,&nbsp;Yang Zhao,&nbsp;Lifeng Li,&nbsp;Ruijie Zhao","doi":"10.1002/brb3.70530","DOIUrl":"https://doi.org/10.1002/brb3.70530","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We seek to investigate the efficacy of safflower yellow pigment in mitigating cerebral ischemia-reperfusion injury by examining its effects on protein nitration and oxidative modification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 160 patients with acute ischemic stroke admitted to the department of neurology of Xingtai people's hospital were included in this study. This study was a retrospective study. Patients were divided into the control group (<i>n</i> = 80) and the observation group (<i>n</i> = 80) according to whether safflower yellow pigment was used. The control group received conventional treatment, and the observation group received safflower yellow pigment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Baseline characteristics did not significantly differ between the two groups (<i>p</i> &gt; 0.05). Serum nitrosine levels were lower in the observation group compared to the control group after 24 h and one week of treatment (<i>p</i> &lt; 0.05). Similarly, serum carbonylated protein levels were lower in the observation group after 24 h and one week of treatment (<i>p</i> &lt; 0.05). The observation group exhibited lower NIHSS and modified rankin scale (mRS) scores, reduced cerebral ischemic area. Furthermore, levels of malondialdehyde (MDA), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) were lower, while superoxide dismutase (SOD) activity was higher in the observation group compared to the control group after one week of treatment (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Safflower yellow pigment demonstrates significant neuroprotective effects in patients with cerebral ischemia-reperfusion injury by reducing protein oxidation and nitration, improving neurological function, reducing cerebral ischemic area, and attenuating oxidative stress and inflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fusion-Brain-Net: A Novel Deep Fusion Model for Brain Tumor Classification","authors":"Yasin Kaya,&nbsp;Ezgisu Akat,&nbsp;Serdar Yıldırım","doi":"10.1002/brb3.70520","DOIUrl":"https://doi.org/10.1002/brb3.70520","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>Brain tumors are among the most prevalent and lethal diseases. Early diagnosis and precise treatment are crucial. However, the manual classification of brain tumors is a laborious and complex task.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to develop a fusion model to address certain limitations of previous works, such as covering diverse image modalities in various datasets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We presented a hybrid transfer learning model, Fusion-Brain-Net, aimed at automatic brain tumor classification. The proposed method included four stages: preprocessing and data augmentation, fusion of deep feature extractions, fine-tuning, and classification. Integrating the pre-trained CNN models, VGG16, ResNet50, and MobileNetV2, the model enhanced comprehensive feature extraction while mitigating overfitting issues, improving the model's performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proposed model was rigorously tested and verified on four public datasets: Br35H, Figshare, Nickparvar, and Sartaj. It achieved remarkable accuracy rates of 99.66%, 97.56%, 97.08%, and 93.74%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The numerical results highlight that the model should be further investigated for potential use in computer-aided diagnoses to improve clinical decision-making.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What About the Differences in Body Representation and Body Image Between Stroke Patients and Healthy Controls? Psychological and Clinical Implications","authors":"Maria Grazia Maggio,&nbsp;Amelia Rizzo,&nbsp;Morena De Francesco,&nbsp;Martina Barbera,&nbsp;Muhammad Kamran,&nbsp;Rosaria De Luca,&nbsp;Francesco Corallo,&nbsp;Angelo Quartarone,&nbsp;Rocco Salvatore Calabrò","doi":"10.1002/brb3.70155","DOIUrl":"https://doi.org/10.1002/brb3.70155","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The integrity of body representation can be profoundly compromised in neurological patients. This study aims to evaluate body representation in both healthy individuals and stroke patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The study included 40 chronic stroke patients recruited from the Neurorehabilitation Unit, IRCCS Centro Neurolesi “Bonino-Pulejo,” and 40 healthy controls from the University of Messina. Both groups were age- and gender-matched. All participants completed the Body Uneasiness Test to assess body image discomfort and body schema accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 80 participants were enrolled, divided equally into two groups matched by gender: stroke patients and healthy controls. Healthy controls showed higher scores in compulsive self-monitoring (<i>p </i>= 0.023), while stroke patients exhibited greater depersonalization (<i>p </i>= 0.039) and significantly higher psychological distress (<i>p</i> ≤ 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>These findings underscore the complexity of bodily and psychological experiences in both health and disease, emphasizing the need for tailored clinical interventions. While the direct impact on quality of life may vary, addressing these issues can contribute to improved overall well-being for both groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Spatial Voxel-Scale Modulation of Acupuncture on Abnormal Brain Activity in Migraine Patients Without Aura: A Randomized Study Neuroimaging Trial","authors":"Chaorong Xie,&nbsp;Zhiyang Zhang,&nbsp;Yutong Zhang,&nbsp;Xixiu Ni,&nbsp;Yang Yu,&nbsp;Xiaoyu Gao,&nbsp;Mingsheng Sun,&nbsp;Xiao Wang,&nbsp;Ling Zhao","doi":"10.1002/brb3.70536","DOIUrl":"https://doi.org/10.1002/brb3.70536","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The role of acupuncture in treating migraine has been widely recognized, but the systematic, comprehensive and, multi-spatial voxel-scale mechanism of brain function changes is still unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the modulatory effect of acupuncture on brain activity in patients with migraine without aura (MwoA) at different spatial voxel scales.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 64 patients with MwoA were randomized into true acupuncture (TA) and sham acupuncture (SA) groups. MwoA patients received TA or SA three times a week for four weeks, a total of 12 sessions. A clinical symptoms assessment and rs-fMRI scans were evaluated before and after four weeks of treatment. Amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF), regional homogeneity (ReHo), and degree centrality (DC) were used to evaluate the spontaneous activity, activity coherence and connectivity importance of brain function at the single voxel, local voxel, and global voxel scales, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The clinical symptoms of both groups were improved compared with baseline. There were significant differences between the TA group and the SA group in migraine frequency, days and pain intensity. The neuroimaging data suggest that TA modulates a broader and more significant brain neural activity than SA. TA modulates the neural activity of the default mode network (DMN), visual network (VN), and sensorimotor network (SMN) at the single voxel scale, local voxel scale and global voxel scale, and these changes are correlated with the improvement of the migraine and quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TA could exert therapeutic effects at different spatial voxel scales by modulating the DMN, VN, and SMN, which may be the neuroimaging mechanism of acupuncture for MwoA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronotype Predicts Body Mass Index via Emotion Regulation Strategy Use and Emotional Eating","authors":"Gregory S. Keenan,&nbsp;Sakina Hosseni,&nbsp;Robert C. A. Bendall","doi":"10.1002/brb3.70542","DOIUrl":"https://doi.org/10.1002/brb3.70542","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Rates of obesity are increasing across all regions representing a critical public health concern. An evening chronotype has been associated with elevated body mass index and a less nutritious diet. However, the mechanisms underpinning the relationship between chronotype and body mass index remain unclear. The aim of the current study was to investigate if chronotype is indirectly associated with body mass index via emotion regulation strategy use and emotional eating.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Participants completed the Morningness-Eveningness Questionnaire to assess chronotype, the Emotion Regulation Questionnaire to assess habitual emotion regulation strategy use, the Warwick-Edinburgh Mental Well-being Scale to assess mental well-being, and the Three-Factor Eating Questionnaire to provide a measure of emotional eating. Participants reported their weight and height to allow body mass index to be calculated. Structural equation modeling tested the predicted indirect association between chronotype and body mass index via emotion regulation strategy use and emotional eating.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Chronotype was indirectly associated with body mass index via emotion regulation strategy use and emotional eating. As predicted, individuals with an evening chronotype tended to report greater use of expressive suppression, which was associated with a greater tendency to emotionally eat and a higher body mass index (&lt;i&gt;p&lt;/i&gt; = 0.008). In contrast, individuals with a morning chronotype reported more frequent use of cognitive reappraisal, which was associated with reduced emotional eating and a lower body mass index (&lt;i&gt;p&lt;/i&gt; = 0.003). The direct pathway between chronotype and body mass index was non-significant (&lt;i&gt;p&lt;/i&gt; = 0.821).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;These findings suggest a clear pathway through which chronotype might be associated with body mass index, with evening chronotypes at a greater risk of weight gain. Our results suggest that it is not the independent influence of emotion regulation strategy use &lt;i&gt;or&lt;/i&gt; emotional eating on its own that is important in the association between chronotype and body mass index, but the &lt;i&gt;combined sequential effect&lt;/i&gt; of a general tendency towards an emotion regulation strategy and then the impact this has upon emotional eating that is important. The findings highlight the importance of considering emotion regulation strategy use and emotional eating when designing interventions or therapies aimed at re","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}