Brain and Behavior最新文献

{"title":"GABAergic Signaling Underlying REM Sleep Deprivation-Induced Spatial Working Memory Deficits","authors":"Peeraporn Varinthra,&nbsp;Shu-Ching Shih,&nbsp;Ingrid Y Liu","doi":"10.1002/brb3.70607","DOIUrl":"https://doi.org/10.1002/brb3.70607","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Declining spatial working memory (WM) is an early hallmark of Alzheimer's disease (AD). Sleep disturbance exacerbates spatial WM and increases AD risk. The GABAergic system, crucial for sleep regulation, may mediate this link. We thus investigate the relationship between spatial WM and hippocampal GABAergic signaling during rapid eye movement sleep deprivation (REM-SD) in AD model mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We assessed spatial and non-spatial WM, locomotor activity, and anxiety-like behavior in 6-month-old triple transgenic (3xTg) AD mice and wild-type (WT) controls, with and without REM-SD (5 days, 4 h/day). We then used immunofluorescence to quantify GABA_Aα1, GABA_BR1, GAD67, and GABA levels in the prefrontal cortex (PFC) and hippocampus and analyze the correlations with behavioral outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>REM-SD increased locomotor activity, reduced anxiety-like behavior, and improved non-spatial WM in 3xTg-AD mice. Conversely, REM-SD impaired spatial WM in WT mice, which was also demonstrated in 3xTg-AD mice. Increased hippocampal GABA levels are correlated with improved non-spatial WM in 3xTg+SD mice. In contrast, impaired spatial WM in WT+SD mice was associated with elevated hippocampal GABA and GABA_BR1, decreased hippocampal GAD67, and reduced PFC GABA levels. Notably, spatial WM in 3xTg+SD and 3xTg control mice related to increased GABA_Aα1 in the PFC and hippocampus and GAD67 in hippocampal CA1, along with decreased GABA_BR1 and GAD67 in the dentate gyrus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>REM-SD-induced alterations in WM performance are linked to GABAergic signaling changes in the PFC and hippocampus, with distinct patterns in WT and 3xTg-AD mice. This study provides insight into AD pathologies and potential therapeutic targets for sleep-related cognitive impairments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70607","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Profiles and Determinants of Eligibility for Awake Surgery in Non-Dominant Hemisphere Gliomas: A Narrative Review","authors":"Alice Tomaselli,&nbsp;Antonina Luca,&nbsp;Gianluca Ferini,&nbsp;Giuseppe Emmanuele Umana,&nbsp;Bipin Chaurasia,&nbsp;Gianluca Scalia","doi":"10.1002/brb3.70604","DOIUrl":"https://doi.org/10.1002/brb3.70604","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Awake surgery has become a crucial approach in glioma treatment, primarily aimed at maximizing tumor resection while preserving neurological functions. While its application to the dominant hemisphere has been well established, its use in the non-dominant hemisphere remains underexplored. The non-dominant hemisphere plays essential roles in visuospatial processing, social cognition, and executive functions, which can significantly impact a patient's quality of life. Despite increasing evidence of these functions, standardized protocols for intraoperative brain mapping (ioBM) in the non-dominant hemisphere are lacking.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A systematic search of the PubMed database was conducted to identify studies published between 2015 and 2024 that examined cognitive outcomes and ioBM paradigms in awake surgery for right non-dominant hemisphere gliomas. The review included studies that assessed neuropsychological outcomes, tumor characteristics, and the extent of surgical resection. Exclusion criteria included case reports, reviews, and studies focused exclusively on dominant hemisphere gliomas. A total of 13 studies met the inclusion criteria.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The review identified key cognitive functions assessed during awake surgery, including speech/motor language, visuospatial cognition, executive functions, social cognition, working memory, and sensorimotor functions. Intraoperative neuropsychological assessment primarily used cortical and subcortical stimulation, with a variety of cognitive tests applied to different domains. Studies reported that direct electrical stimulation (DES) revealed functional roles for the right hemisphere in visuospatial attention, social cognition, and executive functions. Patients who underwent awake surgery demonstrated better long-term cognitive outcomes and extended tumor resection compared to those under general anesthesia. However, variability in assessment tools and inconsistent reporting of postoperative outcomes were noted.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Awake surgery combined with ioBM appears to be a viable approach for optimizing tumor resection while preserving cognitive functions in the non-dominant hemisphere. However, the lack of standardized cognitive assessment protocols remains a significant challenge. Future research should focus on establishing a unified set of cognitive tests for intraoperative assessment, conducting longitudinal studies on cognitive recovery, and integrating adv","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis","authors":"Omid Mirmosayyeb,&nbsp;Danial Dehghani Firouzabadi,&nbsp;Soroush Oraee,&nbsp;Mohammadreza Alinejadfard,&nbsp;Mohammad Yazdan Panah,&nbsp;Saeed Vaheb,&nbsp;Hamed Ghoshouni,&nbsp;Vahid Shaygannejad","doi":"10.1002/brb3.70588","DOIUrl":"https://doi.org/10.1002/brb3.70588","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Multiple sclerosis (MS), as an autoimmune demyelinating disorder, is associated with cognitive dysfunction. Dementia can result from severe cognitive dysfunction or other pathways in MS, but the exact mechanisms and prevalence are unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This review aimed to determine the pooled prevalence and risk of dementia in people with MS (PwMS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>This meta-analysis was performed in accordance with the guidelines established by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Embase, PubMed, Web of Science, and Scopus were comprehensively searched up to August 29, 2024, to identify observational studies that examined the prevalence or hazard ratio (HR) of dementia among PwMS. This meta-analysis used a random-effects model to calculate the pooled prevalence and risk of dementia among PwMS, where the prevalence rate and HR were the main metrics for effect size.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ten studies, including a total of 37,831 PwMS, estimated the prevalence of dementia in PwMS to be 5.31% (<i>I</i>² = 99.2%, 95% CI: 2.25%–11.98%). In addition, a meta-analysis of four studies assessed the HR of dementia among PwMS, revealing a pooled HR of 1.67 (<i>p</i> &lt; 0.01, <i>I</i>² = 73.5%, 95% CI: 1.31–2.13).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While dementia is not a common feature of MS, PwMS still have a significantly higher risk of developing it, compared to healthy indiviuals. However, the considerable variability across studies indicates that these estimates should be interpreted with caution, as inconsistencies in research approaches may have influenced the results. These findings warrant further validation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli","authors":"Aslı Çelik,&nbsp;Cemre Ural,&nbsp;Hatice Efsun Kolatan,&nbsp;Pembe Keskinoğlu,&nbsp;Mehmet Ateş,&nbsp;Zahide Çavdar,&nbsp;Osman Yılmaz,&nbsp;Mehmet Ensari Güneli","doi":"10.1002/brb3.70601","DOIUrl":"https://doi.org/10.1002/brb3.70601","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Housing conditions, which have a major impact on the welfare of laboratory animals, are an important issue in experimental research. Individually ventilated cage (IVC) and open-top cage (OTC) systems are widely used for housing laboratory mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to comprehensively investigate the effects of OTC and IVC housing conditions on the behavior, metabolism, and pain responses of laboratory mice from an animal welfare perspective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We measured body temperature, body weight, anxiety levels (using the elevated plus maze and open field test), and thermal nociceptive responses (using the hot-plate and tail-flick tests) in male albino BALB/c mice. At the end of these procedures, the mice were sacrificed, and the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT), ghrelin, and leptin were determined by ELISA, and the weight of the adrenal glands was measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>The results showed that there were significant differences in body weight, body temperature, anxiety-related behaviors, pain latency, and hormonal parameters between the OTC group and the IVC group. Compared to OTC, IVC had lower levels of leptin, especially under stress conditions, where a significant interaction between housing and stress was observed, and higher levels of ghrelin, ACTH, and CORT. IVC group also had increased body weight, adrenal gland weight, and body temperature. In the hot-plate test, the IVC group showed increased latency of hind limb responses compared to the OTC group, but not in the tail-flick test. IVC group exhibited more anxiety-related behaviors in the OFT, while no differences were observed in the EPM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>According to the results of this study, housing mice in IVCs appears to compromise welfare, altering behavioral, hormonal, and pain responses. This suggests that the IVC system can induce physiological and behavioral stress, potentially acting as a systemic confounding factor in mouse research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Teleworking on Work-Related and Home-Related Stress at During the First Global Lockdown–The International COVISTRESS Study","authors":"Sébastien Couarraze,&nbsp;Guillaume Decormeille,&nbsp;Louis Delamarre,&nbsp;Fouad Marhar,&nbsp;Karen Gbaglo,&nbsp;Raimundo Avilès Dorlhiac,&nbsp;Mickael Berthon,&nbsp;Andy Su-I Liu,&nbsp;Samuel Antunes,&nbsp;Bruno Pereira,&nbsp;Julien S Baker,&nbsp;Morteza Charkhabi,&nbsp;Ukadike C Ugbolue,&nbsp;Reza Bagheri,&nbsp;José J. Gil-Cosano,&nbsp;Marek Zak,&nbsp;The COVISTRESS Network,&nbsp;Maëlys Clinchamps,&nbsp;Frédéric Dutheil","doi":"10.1002/brb3.70592","DOIUrl":"https://doi.org/10.1002/brb3.70592","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The initial lockdown during the pandemic of COVID-19 led to adjustments in working conditions, including extensive use of telecommuting whenever possible, putatively influencing both work-related and home-related stress.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our aim was to measure the impact of teleworking on work-related and home-related during the COVID-19 pandemic.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The international study was conducted using an online questionnaire to collect demographic and stress-related data from individuals worldwide during the 2020 pandemic year. Work-related and home-related stress levels were evaluated using an uncalibrated visual analog scale, with a range from 0 (none) to 100 (maximum).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 13,537 individuals from 44 countries completed the survey between January and June 2020. A total of 7356 individuals were engaged in professional activities. Of these, 6639 continued to work, of which 2573 carried on as usual and 4066 teleworked. The teleworkers demonstrated a considerably (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) lower level of work-related stress (58 ± 31.6) in comparison to those who maintained their usual work schedule (63.6 ± 31.1). However, there was no statistically significant variation in home-related stress between the two groups. The risk of high levels of work-related stress (stress &gt; 80) was multiplied by 1.76 in women (1.54 to 2.01; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), by 1.43 (1.27 to 1.61; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) for those who did not telework, by 5.31 (4.57 to 6.18; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) for those with high levels of home-related stress (stress &gt; 80), and by 1.46 (1.22 to 1.76; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) for those from continents outside Europe. Home-related stress is also a risk factor for work-related stress, and vice versa. Sociodemographic risk factors for higher levels of home-related stress were age &lt; 50 years old, women, working &lt; 50 h per week, continents outside Europe, and not teleworking were no longer risk factors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Telework emerged as a viable option during the initial phase of the global pandemic. This mode of work was associated with lower levels of work-related stress compared to workers who were required to work in a conventional manner. In terms of home-related stress, telecommuters experienced more stress than those who continued to work as usual.&lt;/p&gt;\u0000 ","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Psychotic-Like Experiences and Brain White Matter Microstructure in Young Women","authors":"Rikka Kjelkenes,&nbsp;Sara Fernandez-Cabello,&nbsp;Irene Voldsbekk,&nbsp;Madelene Christin Holm Bukhari,&nbsp;Andreas Dahl,&nbsp;Ingvild Sandø Lofthus,&nbsp;Henning Stople Rise,&nbsp;Christian K. Tamnes,&nbsp;Ivan I. Maximov,&nbsp;Lars T. Westlye","doi":"10.1002/brb3.70587","DOIUrl":"https://doi.org/10.1002/brb3.70587","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psychotic-like experiences (PLE) represent a risk factor for later psychotic disorders and a marker for general mental distress. The connectivity and microstructure of key brain white matter pathways, including fronto–temporal trajectories, have been implicated in psychosis and psychosis-risk. Although sex differences in PLE prevalence and characteristics have been reported, most neuroimaging studies of PLE have primarily included mixed-sex, samples and little research has been carried out in females only. This study examines the associations between PLE and white matter characteristics in young to middle-aged females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed cross-sectional diffusion magnetic resonance imaging (dMRI) and self-reported data from 661 females aged 9–44 years using the 15-item version of The Community Assessment of Psychic Experiences (CAPE) questionnaire. Associations between CAPE subscales and other psychopathology measures were tested. Using linked independent component analysis (LICA), we decomposed the voxel-wise data from 24 dMRI metrics across five different diffusion models into 10 spatially independent components. We then examined the association between the LICA subject weights and age. Next, we tested for associations between the LICA subject weights and both CAPE total and subscales scores using Bayesian statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PLE were broadly associated with various domains of psychopathology and psychosocial factors. Moderate evidence emerged for an association between PLE and an LICA component reflecting a broad and complex pattern of diffusivity in major pathways, including the inferior fronto– occipital fasciculus, anterior thalamic radiation, and forceps minor. The persecutory ideations subscale showed the strongest evidence of an effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PLE in young females are associated with a distinct multimodal white matter pattern reflecting microstructural characteristics in key commissural, association, and thalamocortical pathways in young females. The findings support that LICA is a valuable tool for fusing and decomposing advanced dMRI metrics to delineate white matter patterns that show sensitivity to PLE and mental distress.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological Function and the Relationship Between Subjective Cognition, Objective Cognition, and Symptoms in Hypermobile Ehlers–Danlos Syndrome","authors":"Amber Sousa,&nbsp;Min-Kyung Jung,&nbsp;Arline Allera,&nbsp;Bernadette Riley","doi":"10.1002/brb3.70603","DOIUrl":"https://doi.org/10.1002/brb3.70603","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Hypermobile Ehlers–Danlos syndrome (hEDS), a subtype of the Ehlers–Danlos syndromes, is a connective tissue disorder that is associated with a number of cognitive and psychological symptoms. Very little research has directly examined the neuropsychological functioning profile in hEDS, but some research has found associations of hypermobility with cognitive difficulties, psychological symptoms, and structural brain differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The current research compared a 12-matched-pairs sample of individuals with hEDS to healthy controls on a comprehensive neuropsychological test battery, as well as measures of mood, pain levels, fatigue, subjective cognition, and ability to perform social activities. Participants were matched for age, gender, and years of education. A second analysis was completed for a larger group of 18 participants with hEDS to examine associations of cognition and other symptoms with subjective cognition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our results did not reveal significant cognitive differences between the two groups for most cognitive measures. However, individuals with hEDS had lower scores for delayed verbal memory recall. In the larger hEDS sample, correlations between subjective cognition, objective cognitive test performance, and other clinical variables revealed significant correlations between subjective cognition and visuospatial planning and construction, working memory, and set-shifting. Additionally, subjective cognition was associated with anxiety, depression, fatigue, pain, and the ability to participate in social activities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We conclude that cognitive difficulties reported by individuals with hEDS are likely fluctuating and may correspond with fluctuating symptoms including dysautonomia, pain, and sleep difficulties. Furthermore, subjective cognition appears to be especially correlated with other related symptoms of mood, pain, and fatigue.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Oxidative Stress Gene Protein, Expression, and DNA Methylation on Multiple Sclerosis: A Multi-Omics Mendelian Randomized Study","authors":"Yang Li,&nbsp;Yushi Wang,&nbsp;Shuning Wang,&nbsp;Hui Zhu","doi":"10.1002/brb3.70606","DOIUrl":"https://doi.org/10.1002/brb3.70606","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oxidative stress (OS) is linked to the development of multiple sclerosis (MS), but the causal relationship in terms of genetic pathophysiology remains ambiguous. We employed Mendelian randomization (MR) and colocalization analysis to explore the relationship between OS genes and MS, utilizing an integrative multi-omics approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We obtained data from a genome-wide association study (GWAS) of MS from the International Multiple Sclerosis Genetics Consortium (Discovery phase) and the FinnGen study (Replication phase). Mendelian randomization analyses were conducted using summary data to evaluate the association between molecular features of OS-related genes and MS. Additional colocalization analyses were undertaken to ascertain whether the identified signal pairs shared causal genetic variants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Integration of multi-omics data, including mQTL-eQTL and eQTL-pQTL, revealed that the <i>STAT3</i> gene is associated with MS, supported by Level 1 evidence. The <i>CR1</i> gene shows an association with MS risk, evidenced by Level 3 support. Methylation at cg24718015 and cg17833746 in the <i>STAT3</i> gene correlates with reduced expression of <i>STAT3</i>. At the protein level, high circulating levels of STAT3 are inversely associated with MS risk (OR: 0.43, 95% CI, 0.33–0.54). Elevated levels of TNFRSF1A are also linked with a decreased risk of MS (OR: 0.21; 95% CI, 0.12–0.37), while higher levels of CR1 are positively associated with an increased risk of MS (OR: 1.17; 95% CI, 1.08–1.27).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study identifies specific OS genes that are associated with MS and enhances our understanding of its pathogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors of Post-Lumbar Puncture Headache in Patients With Cognitive Impairment","authors":"Xinhui Wang,&nbsp;Yuchen Qiao,&nbsp;Yuchen Liang,&nbsp;Jinming Han,&nbsp;Hongyan Duan,&nbsp;Yi Tang,&nbsp;Qi Qin","doi":"10.1002/brb3.70597","DOIUrl":"https://doi.org/10.1002/brb3.70597","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cognitive impairment is prevalent among the elderly population. Cerebrospinal fluid (CSF) biomarker tests are employed to facilitate timely and differential diagnosis of cognitive dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate incidence and risk factors of post-lumbar puncture headache (PLPH) in Chinese geriatric patients with cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 254 consecutive patients with cognitive impairment were recruited between March and September 2023 and categorized into two groups: mild cognitive impairment (MCI) and dementia. Different scales, such as the short-form of the McGill pain questionnaire (SF-MPQ), facial visual analogue scale (F-VAS), revised Wong-Baker Assessment of Facial Expression Pain (FPS-R), and Chinese version of Pain Assessment Scale for Advanced Dementia (C-PAINAD), were used to evaluate the incidence of headache after lumbar puncture. Univariate and multivariate factor analyses were conducted to identify potential risk factors, with the most influential predictors included in regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among patients with cognitive disorders, the incidence of PLPH was 24.8%. The incidence and duration of headache did not differ significantly between the MCI and dementia groups. The average time of post-lumbar puncture headache (PLPH) was 22.9 h. There was no significant difference in headache scale scores between MCI patients. The incidence of PLPH in women with cognitive impairment was higher than that in men. The incidence of PLPH in cognitive impairment patients with a history of headache was significantly higher than that in cognitive impairment patients without a history of headache. However, no significant differences were observed in years of education, number of lumbar punctures, length of bed rest, and oral rehydration volume.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PLPH is more commonly observed in women, individuals with a history of headache, younger age, or lower body mass index (BMI). C-PAINAD and SF-MPQ are the preferred assessment tools for evaluating PLPH in patients with cognitive impairment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice","authors":"Maria Vedunova,&nbsp;Olga Borysova,&nbsp;Elena Mitroshina,&nbsp;Ivan Morgunov,&nbsp;Alexander Fedintsev,&nbsp;Alexey Moskalev","doi":"10.1002/brb3.70573","DOIUrl":"https://doi.org/10.1002/brb3.70573","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Targeting partial cellular reprogramming pathways through specific small molecule combinations holds promise for lifespan extension in model organisms. Chemical cocktails like RepSox and tranylcypromine (TCP) may induce beneficial age-related changes without the risks of full reprogramming. This study investigated the effects of RepSox and TCP on neurological markers, physical activity, skeletal health, and survival in aging C3H female mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Female C3H mice were divided into two age groups: “old” (16–20 months) and “senior” (10–13 months). They received intraperitoneal injections of RepSox (5 mg/kg) and TCP (3 mg/kg) or DMSO (control) every 72 h for 30 days. Physiological state, neurological scores, open field test performance, skeletal deformation, and survival were assessed. Histological analyses of organs (brain, liver, heart, kidneys, lungs, muscles) were performed post-treatment. Statistical analyses included Mann-Whitney tests, mixed-effects linear regression, Kaplan-Meier survival analysis, and the Gao-Allison test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>In the “old” group, treated mice showed enhanced neurological status, fur and skeletal health, and increased cortical angiogenesis, though with some adverse histological changes in the liver and brain. In the “senior” group, treated mice displayed a plateau in mortality after month seven, while deaths continued in controls. Although overall survival was not significantly different, maximum lifespan significantly increased in treated mice (p = 0.039, Gao-Allison test). Histological findings revealed localized adaptive changes rather than major toxic effects. These results suggest that the combination of RepSox and TCP exerts protective effects on aging phenotypes and may potentially slow systemic aging processes in C3H mice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}