Brain and Behavior最新文献

{"title":"An Exploratory Analysis of Rhythmic Auditory Stimulation's Impact on Brain Function in Parkinson's Disease Patients With Freezing of Gait","authors":"Chen Liu,&nbsp;Miaomiao Hou,&nbsp;Shuili Yu,&nbsp;Ying Wan,&nbsp;Zhenguo Liu,&nbsp;Jing Gan","doi":"10.1002/brb3.70532","DOIUrl":"https://doi.org/10.1002/brb3.70532","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Freezing of gait (FOG) is a debilitating symptom in Parkinson's disease (PD) patients that severely impairs mobility. Rhythmic auditory stimulation (RAS) has demonstrated potential in improving gait, but the mechanisms underlying its efficacy remain unclear. This study explored the impact of RAS on brain function in PD patients with FOG using functional near-infrared spectroscopy (fNIRS) during an imagined walking task, with the aim of elucidating the underlying mechanisms involved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We enrolled 45 PD patients, comprising 21 with FOG (PD+FOG), 24 without FOG (PD-FOG), and 10 healthy controls (HC). Using a 53-channel fNIRS system, we measured the oxygenated hemoglobin (oxy-Hb) content in brain regions as subjects performed an imagined walking task both with and without RAS. Dynamic functional connectivity and k-means clustering were employed to identify key brain connectivity states. Data processing was conducted using MATLAB R2014a, with one-way ANOVA to select channels of interest, followed by paired t-tests for comparative analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PD+FOG patients showed significantly lower activation in the supplementary motor area (SMA) and the left primary motor cortex of the lower limb (M1-LL) without RAS compared to PD-FOG patients and HC. RAS significantly increased activation in these areas and altered functional connectivity, characterized by an increased frequency of transitions between low-strength and medium-strength connectivity states in PD+FOG patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RAS may ameliorate gait in FOG patients by activating key motor areas (SMA and left M1-LL) and modulating the dynamic regulation of brain connectivity. This research provides valuable insights into the neural processes involved in the therapeutic effects of RAS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Aging of Patients With Amyotrophic Lateral Sclerosis: A Preliminary Longitudinal Study","authors":"Sana Mohammadi,&nbsp;Sadegh Ghaderi,&nbsp;Farzad Fatehi,&nbsp;Sanjay Kalra,&nbsp;Seyed Amir Hossein Batouli","doi":"10.1002/brb3.70484","DOIUrl":"https://doi.org/10.1002/brb3.70484","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This longitudinal study investigated pathological brain aging in amyotrophic lateral sclerosis (ALS) by evaluating disparities between chronological age and deep learning-derived brain structure age (BSA) and exploring associations with cognitive and functional decline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten limb-onset ALS patients (seven males) and 10 demographically matched healthy controls (HCs) underwent structural magnetic resonance imaging (sMRI) and cognitive assessments at baseline and follow-up. The BSA was estimated using the validated volBrain platform. Cognitive domains (language, verbal fluency, executive function, memory, and visuospatial skills) and global cognition (Persian adaptive Edinburgh Cognitive and Behavioral ALS Screen [ECAS] total score) were assessed along with functional status (ALSFRS-R).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ALS patients exhibited significant BSA-chronological age disparities at baseline (Δ = +7.31 years, <i>p</i> = 0.009) and follow-up (Δ = +8.39 years, <i>p</i> = 0.003), with accelerated BSA progression over time (<i>p</i> = 0.004). The HCs showed no such disparities (<i>p</i> = 0.931). Longitudinal BSA increases were correlated with executive function decline (<i>r</i> = −0.651, <i>p</i> = 0.042). Higher education predicted preserved language (<i>r</i> = 0.831, <i>p</i> = 0.003) and verbal fluency (<i>r</i> = 0.738, <i>p</i> = 0.015). ALSFRS-R decline paralleled visuospatial (<i>r</i> = 0.642, <i>p</i> = 0.045) and global cognitive deterioration (<i>r</i> = 0.667, <i>p</i> = 0.035).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ALS is characterized by accelerated structural brain aging that progresses independently of chronological age and is correlated with executive dysfunction. Education may mitigate cognitive decline, while motor functional deterioration aligns with visuospatial and global cognitive impairments. BSA has emerged as a potential biomarker for tracking pathological aging trajectories in ALS, warranting validation using larger cohorts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State Functional Connectivity of Sensorimotor and Default Mode Networks and Lower Limb Performance in Chronic Stroke: A Cross-Sectional Study","authors":"Svetlana Pundik,&nbsp;Margaret M. Skelly,&nbsp;Jessica P. McCabe,&nbsp;Ahlam I. Salameh,&nbsp;Trenley Anderson,&nbsp;Kelsey Rose Duncan,&nbsp;Terri Hisel,&nbsp;Sarah J. A. Carr","doi":"10.1002/brb3.70519","DOIUrl":"https://doi.org/10.1002/brb3.70519","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Stroke disrupts functional brain connectivity, yet how this relates to lower limb motor and sensory abilities is not well understood. Greater knowledge of movement-related brain connectivity can aide in the development of better interventions for recovery after stroke. Our objective was to evaluate the relationship between lower limb performance and resting-state functional connectivity (rsFC) of large-scale brain networks for individuals with chronic motor deficits (&gt; 6 months) after stroke.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Resting-state functional magnetic resonance imaging and lower limb clinical measures were collected for 37 individuals. Regions of interest (ROI)-to-ROI connectivity analysis was conducted for cortical sensorimotor network (SMN) (cortical SMN), SMN with both cortical and subcortical ROIs (SMN), and default mode network (DMN). Relationship of ROI–ROI connectivity and clinical measures or lesion load was assessed using general linear models. Graph theory metrics (global efficiency, clustering coefficient, and betweenness centrality) were related to clinical measures using elastic nets analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Greater connectivity between several SMN and DMN ROI pairs was associated with better gait speed, Timed-Up-and-Go score, and monofilament perception. The majority of ROI pairs showing statistically significant relationship with clinical measures were interhemispheric, non-homologous, and cortical-to-subcortical. Elastic net analysis for graph theory metrics revealed complexity and multi-directionality of the relationship of the individual ROIs to clinical outcomes and lesion load. There were unique sets of ROIs associated with each clinical measure for different graph metrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>rsFC between specific ROIs within SMN and DMN are related to lower limb performance. Non-homologous interhemispheric ROI-to-ROI connectivity was featured in the analysis. Graph theory analysis demonstrates the complex role that an individual ROI has in relation to sensorimotor function of lower extremity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Clinicialtrials.gov registration number NCT03666533</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Sclerosis and Seizures: Clinical, Diagnostic and Therapeutic Correlations","authors":"C. Wood,&nbsp;S. Owen,&nbsp;S. Ebden,&nbsp;B. Anand,&nbsp;M. Wardle,&nbsp;K Hamandi,&nbsp;K. L. Kreft,&nbsp;N. P. Robertson,&nbsp;E. C. Tallantyre","doi":"10.1002/brb3.70511","DOIUrl":"https://doi.org/10.1002/brb3.70511","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Seizures occur more commonly in people with multiple sclerosis (pwMS) than in the general population. Existing studies correlating clinical, diagnostic and therapeutic outcomes for pwMS and seizures are lacking. We determine the prevalence of seizure(s) in people with MS/clinically isolated syndrome (CIS) and characterize a population-based cohort of pwMS/CIS and seizure(s).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used the South Wales MS registry to identify all people with MS/CIS and a lifetime history of seizure living within Cardiff and Vale. Retrospective clinical data were extracted from electronic records. Prevalent populations of (i) lifetime history of seizure(s) (ii) epilepsy diagnosis in pwMS/CIS were calculated on the January 1st, 2020 for the catchment area. MR brain images nearest to time of first seizure were reviewed and compared to a contemporary, matched cohort of pwMS without seizures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 49 historical cases of co-existent MS/CIS and seizure(s). On January 1st, 2020, we found that 2.4% (23/950, 95% CI 1.4%–3.4%) of the prevalent population of people with MS/CIS had experienced a seizure and 2.1% (20/950, 95% CI 1.2%–3.0%) had a diagnosis of epilepsy, which is higher than the general population (0.76%). Seizure(s) occurred before other symptoms of MS in 15/49 and after MS in 34/49. One patient (2%) experienced a seizure during MS relapse. First seizure occurred during treatment with fingolimod in three patients and with fampridine in one patient. Analysis of MR brain images suggests that pwMS and seizures have a higher number of T2 lesions and more marked brain atrophy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests that approximately 2.4% of people with MS/CIS are expected to experience seizure(s). Seizures in MS are associated with higher overall brain disease burden.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrysin Modulates Behavior and Hippocampal Histopathology in Adult Male Hypoandrogenic Rats: The Regulatory Role of miR-30a, miR-375, and miR-204","authors":"Amir-Hossein Ebadi,&nbsp;Maryam Moghimian,&nbsp;Seyd-Hossein Abtahi-Evari,&nbsp;Zahra Saadatian,&nbsp;Alireza Fathi,&nbsp;Malihe Soltani","doi":"10.1002/brb3.70529","DOIUrl":"https://doi.org/10.1002/brb3.70529","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Hypoandrogenism, a condition linked to oxidative stress and hippocampal cell death, can lead to learning and memory disorders in aging men or those with hypogonadism. Recently, microRNAs such as miR-30a, miR-375, and miR-204 have been identified as regulators of cell death and memory formation. Flavonoid antioxidants that modulate microRNA expression offer a potential therapeutic approach for neurodegenerative conditions. This study examines the effects of the flavonoid chrysin on these microRNAs, cell death processes, and memory under hypoandrogenic stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Rats were assigned to six groups: control, hypoandrogenic, hypoandrogenic treated with chrysin (50 mg/kg and 75 mg/kg), and chrysin treated alone (50 mg/kg and 75 mg/kg). After 14 days, memory changes were assessed using the Morris water maze test, along with evaluations of oxidative stress enzymes, apoptosis and autophagy, miR-30a, miR-375, and miR-204 gene expression, and the number of dark neurons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Hypoandrogenism increased apoptosis and autophagy gene expression, dark neurons, oxidative stress enzymes, and decreased memory and microRNA expression compared to controls. Treatment with chrysin (75 mg/kg) significantly reduced apoptosis and autophagy gene expression, dark neurons, and oxidative stress enzymes, and improved memory and learning. This group also showed modulation of miR-30a, miR-375, and miR-204 levels compared to the hypoandrogenic group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hypoandrogenism led to neurodegeneration and memory impairment, likely due to oxidative stress affecting miR-30a, miR-375, and miR-204 regulation. Chrysin (75 mg/kg) potentially mitigates cell death processes and memory deficits in hypoandrogenism by modulating these microRNAs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppression of Deactivation of Working Memory and Promotion of Activation of Sustained Attention in the Default Mode Network Are Affected by Schizotypy in a Large Sample of Nonclinical Subjects","authors":"Seishu Nakagawa,&nbsp;Hikaru Takeuchi,&nbsp;Yasuyuki Taki,&nbsp;Ryoichi Yokoyama,&nbsp;Kohei Sakaki,&nbsp;Kelssy Hitomi dos Santos Kawata,&nbsp;Takayuki Nozawa,&nbsp;Susumu Yokota,&nbsp;Tsuyoshi Araki,&nbsp;Rui Nouchi,&nbsp;Ryuta Kawashima","doi":"10.1002/brb3.70449","DOIUrl":"https://doi.org/10.1002/brb3.70449","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Schizotypy is a personality trait characterized by subclinical expression of the signs and symptoms of schizophrenia. Maladaptive schizotypy is given the clinical designation of schizotypal personality disorder. Previous studies have shown that functional disturbance of the default mode network (DMN) is associated with maladaptive schizotypy. Working memory impairment is a particularly common feature of maladaptive schizotypy and schizophrenia. As these characteristics can also be observed in the healthy population, our purpose was to identify the neural correlates of schizotypy during sustained attention tasks and working memory tasks in nonclinical subjects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We recruited 409 healthy individuals (251 men and 158 women; 20.7 ± 1.8 [SD] years of age) and determined their schizotypy scores using the Schizotypal Personality Questionnaire. We used a typical functional MRI (fMRI) task under 0-back and 2-back conditions. Corrections for multiple comparisons were performed via the threshold-free cluster enhancement method with a familywise error-corrected threshold of <i>p</i> &lt; 0.0167 (0.05/3) at the whole-brain level, including the cerebellum.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Suppression of deactivation of the DMN (the medial prefrontal cortex (mPFC), the posterior cingulate cortex, the inferior parietal lobule, and the middle temporal gyrus) in the working memory (2-back &gt; rest) task and promotion of activation during the sustained attention (0-back &gt; rest) task were associated with schizotypy scores. Among the schizotypy subscores, cognitive–perceptual deficits were significantly related only to the left precuneus, the mPFC, and the superior temporal gyrus for the 2-back &gt; 0-back contrast; to the left precuneus and the bilateral mPFC for the 2-back &gt; rest contrast; and to the left superior temporal cortex and the right precuneus for the 0-back &gt; rest contrast within the DMN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Disturbance of the DMN is related to the degree of schizotypy, especially to the degree of cognitive‒perceptual deficits, even in nonclinical subjects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Role of α2δ-1 in Cerebral Hemorrhage: Calcium Overload, Endoplasmic Reticulum Stress, and Microglial Apoptosis","authors":"Ning Yu,&nbsp;Xiaopeng Li,&nbsp;Bingqian Wang,&nbsp;Chengrui Nan,&nbsp;Qianxu Jin,&nbsp;Liang Yang,&nbsp;Depei Li,&nbsp;Zongmao Zhao","doi":"10.1002/brb3.70499","DOIUrl":"https://doi.org/10.1002/brb3.70499","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Cerebral hemorrhage is a severe condition associated with high morbidity and mortality. Understanding the underlying pathogenesis is crucial for developing effective therapeutic strategies. This study aimed to investigate the role of the dysregulated α2δ-1 protein in cerebral hemorrhage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We observed a significant upregulation of α2δ-1 in cerebral hemorrhage tissue. Knockdown of α2δ-1 resulted in decreased intracellular calcium concentration and reduced phosphorylation of PLCr and IP3R in the presence of calcium. Additionally, α2δ-1-mediated calcium overload induced ERS in BV2 microglia, accompanied with increased phosphorylation of PERK and decreased ERS-related protein levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>α2δ-1 knockdown significantly inhibited BV2 microglia apoptosis and downregulated apoptosis-related proteins in the presence of calcium. Our study indicates the involvement of α2δ-1 in calcium-mediated signaling, endoplasmic reticulum stress, and BV2 microglia apoptosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings provide a basis for considering α2δ-1 as a potential therapeutic target in cerebral hemorrhage and secondary brain injury conditions associated with calcium dysregulation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Psychological Burden Among Family Caregivers of People Living With Dementia, Parkinson's, and Alzheimer's Disease Using the Zarit Burden Interview From Bangladesh","authors":"Md. Rashidur Rahman,&nbsp;Noorjahan Aktar,&nbsp;Farhana Islam","doi":"10.1002/brb3.70527","DOIUrl":"https://doi.org/10.1002/brb3.70527","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to explore the burden experienced by family caregivers of individuals with dementia, Alzheimer's disease (AD), and Parkinson's disease (PD) in Bangladesh. It sought to identify the key contributing factors and determine the primary predictors influencing caregiver burden in this context.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seventy-five caregivers were selected on the basis of specific criteria. The Zarit burden interview was used to assess the caregiver burden among patients with dementia, AD and PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 75 participants were assessed, with 50 (66.67%) being female. Most caregivers (40.0%) were spouses. Overall, caregivers experienced a moderate level of burden, with female caregivers reporting a higher burden compared to their male counterparts. Caregiver burden was significantly associated with age and the patient-caregiver relationship.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Greater research focus is needed on caregivers of patients with neurodegenerative diseases in developing countries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition-Associated Changes in Retinal Thickness Relate to Limbic and Temporal Cortical Atrophy in Parkinson's Disease","authors":"Kerstin Schweyer,&nbsp;Tobias Mantel,&nbsp;Benjamin Knier,&nbsp;Lilian Aly,&nbsp;Jan S. Kirschke,&nbsp;Tobias Meindl,&nbsp;Bernhard Haslinger","doi":"10.1002/brb3.70509","DOIUrl":"https://doi.org/10.1002/brb3.70509","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background:</h3>\u0000 \u0000 <p>Research links retinal changes to cognitive decline in Parkinson's disease (PD), paralleling findings in Alzheimer's, raising questions about specific cortical patterns of cognition-related retinal abnormalities in PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective:</h3>\u0000 \u0000 <p>The study aimed to explore whether retinal thinning linked to cognitive decline could act as a potential biomarker for cerebral atrophy in PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods:</h3>\u0000 \u0000 <p>Twenty seven patients with PD underwent cognitive and neurological assessments, along with retinal imaging using OCT and cerebral imaging using structural MRI. After identifying abnormal retinal layers associated with cognitive dysfunction through partial correlation analyses controlling for age-related effects, associations between these retinal layers and the parcellated cerebral gray matter were assessed using multiple comparison-corrected partial correlation analyses adjusted for age and gender.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results:</h3>\u0000 \u0000 <p>Significant positive correlations were found between cognitive impairment measured by MoCA and specific retinal layers (IPL, GCL, and RNFL). Of these, strong associations were observed between the IPL and GCL and cortical thickness in brain the temporal lobe and limbic cortex, with more detailed further analysis showing significant correlations particularly within the middle and posterior cingulate cortex in the limbic cortex and the middle and superior temporal gyrus in the temporal lobe.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion:</h3>\u0000 \u0000 <p>Correlations between retinal thinning, cognitive decline, and specific patterns of cortical atrophy in PD support a potential of retinal measurements as a biomarker for cognitive impairment linked to cerebral neurodegeneration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Soluble Platelet-Derived Growth Factor β Receptor Induces Postoperative Delirium by Downregulating the Clearance of β-Amyloid in the Brain","authors":"Zongfeng Guo,&nbsp;Chen Zhang,&nbsp;Xiang Wang,&nbsp;Weiguo Chen,&nbsp;Zongxiao Guo","doi":"10.1002/brb3.70436","DOIUrl":"https://doi.org/10.1002/brb3.70436","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose:</h3>\u0000 \u0000 <p>To investigate the relationship between soluble platelet-derived growth factor β receptor (sPDGFRβ) in cerebrospinal fluid (CSF) and Alzheimer's disease (AD) biomarkers, to determine whether high CSF sPDGGFRβ is a potential risk factor for postoperative delirium (POD), and to evaluate its predictive effect, so as to provide reference for clinical prevention and treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods:</h3>\u0000 \u0000 <p>CSF samples were collected preoperatively from cognitively normal participants aged 50–90 years undergoing knee/hip replacement surgery under spinal-epidural anesthesia. The concentrations of sPDGFRβ, β-amyloid 42 (Aβ42), total tau protein (Ttau), and phosphorylated tau protein (Ptau) in CSF were detected by enzyme-linked immunosorbent assay (ELISA). The confusion assessment method (CAM) was used to evaluate whether participants developed POD after surgery, and they were divided into the POD group and non-POD group (NPOD). The relationship between CSF sPDGFRβ, AD biomarkers, and POD was analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results:</h3>\u0000 \u0000 <p>The level of sPDGFRβ, a marker of brain pericyte injury, was significantly increased in POD patients (<i>p</i> &lt; 0.05), and the difference was still statistically significant after adjusting for multiple confounders (<i>p</i> &lt; 0.05). CSF Aβ42 showed a significant mediating effect between CSF sPDGFRβ level and POD (22.45%). The combination of AD biomarkers and CSF sPDGFRβ predicted POD better than that of AD biomarkers or CSF sPDGFRβ alone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion:</h3>\u0000 \u0000 <p>The results suggest that the increase in CSF sPDGFRβ is associated with an increased risk of POD due to the blood–brain barrier (BBB) dysfunction and reduced Aβ42 clearance. In this study, the correlation between CSF sPDGFRβ and POD was investigated for the first time, providing a new reference index for POD prediction. However, this paper did not study other relevant indicators of the BBB and lacked follow-up, which could be further improved in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}