Brain and Behavior最新文献

{"title":"Genetic and Genomic Literacy of Healthcare Providers Treating Anorexia Nervosa in the United States: A Mixed Methods, Cross-Sectional Study","authors":"Sarah Ramsay,&nbsp;Kendra Allison,&nbsp;Heide S. Temples,&nbsp;William C. Bridges Jr.,&nbsp;Sara Sarasua","doi":"10.1002/brb3.70441","DOIUrl":"https://doi.org/10.1002/brb3.70441","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Genetic testing has the potential to transform the prevention, treatment, and management of anorexia nervosa (AN) as it has for other conditions. However, healthcare providers require the knowledge and openness to implement genetic testing effectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study had two main objectives, first, to determine the genomic literacy of those treating AN in the United States and second to assess the viewpoints of these healthcare providers on genetic testing and research, and the influence of genetics on AN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A mixed methods approach combining the GKnowM, a validated genomic literacy tool, Likert-like statements and thematic analysis of free-text responses was used. Participant consent, dissemination of the survey, and response collection were performed through Qualtrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participant's average GKnowM score was 19.6 (SD = 2.8) on a scale of 0–26 (75% correct). Positive correlations were identified between GKnowM score and responses to questions about the influence of genetics on AN and the importance of genetics research, and negative correlations were found between age and years in practice and views on the current value of genetic testing. In addition, participants communicated a need for more genetics learning opportunities, and the challenge of accessing and paying for quality AN treatment in the United States.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>The results of this study indicate a need for targeted genetics and genomics learning opportunities for healthcare providers. Improving genomic literacy has the potential to positively influence attitudes toward genetic research and testing and empower healthcare providers to engage in productive and scientifically sound discussions with their patients and society as a whole.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Italian Survey on the Management of Pediatric Convulsive Status Epilepticus: More Than Just a Pharmacological Choice","authors":"Caterina Zanus,&nbsp;Giulia Cannizzaro,&nbsp;Giacomo Danieli,&nbsp;Angela Amigoni,&nbsp;Silvia Buratti,&nbsp;Francesca Izzo,&nbsp;Massimo Mastrangelo,&nbsp;Maria Cristina Mondardini,&nbsp;Paola Costa,&nbsp;Anna Rosati,&nbsp;Carla Marini,&nbsp;Lucia Fusco,&nbsp;Italian Paediatric Status Epilepticus Group","doi":"10.1002/brb3.70433","DOIUrl":"https://doi.org/10.1002/brb3.70433","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>To explore specialists’ opinions on the current management of pediatric convulsive status epilepticus (CSE) in Italy and the main factors influencing the applicability of guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a national survey of child neurologists, pediatric emergency physicians, and intensivists. Within the multidisciplinary Italian Paediatric Status Epilepticus (IPSE) Group, a web-based 48-multiple-choice questionnaire was developed to explore treatment choices, use of internal protocols and guidelines, and self-perceived competencies in the treatment of CSE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Responses were received from 250 clinicians from 34 Italian hospitals (response rate 71%). Intravenous midazolam (iv-MDZ) was the preferred benzodiazepine (BDZ) when iv access was available (90%). When iv-access was unavailable, 75% of clinicians used BDZs; rectal diazepam was the most indicated (65.6%). Concerning second-line treatment, the choices were equally distributed between phenytoin (55.2%), levetiracetam (52.4%), and phenobarbital (52.4%). MDZ infusion at a dosage &lt; 0.23 mg/kg/h was also a frequent choice (38%). A PICU in the hospital influenced this latter choice, resulting in a significantly greater use of iv-MDZ by pediatric emergency physicians working in these hospitals. Answers’ variability was related to organizational aspects such as the availability of on-duty specialists and diagnostic tools in emergency settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This survey confirmed that first-line treatment of pediatric CSE relied on iv-MDZ and that the heterogeneity of therapeutic choices started from the second-line treatment in real life. The survey also highlighted the need to consider the organizational heterogeneity among settings and to involve different specialties in an integrated and feasible approach.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domain-Specific and Domain-General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task-Based and Functional Connectivity Meta-Analysis","authors":"Valentino Marcel Tahamata,&nbsp;Yang-Teng Fan,&nbsp;Li Wei,&nbsp;Yen-Nung Lin,&nbsp;Roger Marcelo Martinez,&nbsp;Kah Kheng Goh,&nbsp;Yu-Chun Chen,&nbsp;Chenyi Chen","doi":"10.1002/brb3.70438","DOIUrl":"https://doi.org/10.1002/brb3.70438","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Patients with Type 2 diabetes experience cognitive and affective deficits linked to widespread functional brain alterations. However, previous meta-analyses of functional neuroimaging have primarily focused on the resting-state studies. While valuable, this approach may have overlooked the key neuronal mechanisms underlying these deficits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To address this, we conducted a coordinate-level task-based meta-analysis of functional neuroimaging via a systematic search of Embase, PubMed, Medline, and Web of Science (December 2023), alongside task-based and task-free connectivity analyses using the BrainMap database. Activation likelihood estimations were applied to two task categories: that are, cognitive and affective. To control for biased results, we also conducted jackknife sensitivity analysis and within-paper combined experiments analysis as validation analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified a cluster of activation in cognitive paradigm (18 contrasts, 153 foci, 767 subjects), with the middle frontal gyrus, part of the medial frontal cortex, as the peak region. For the affective paradigm (18 contrasts, 181 foci, 951 subjects), we observed both increased and decreased activities. Two increased clusters peak in the amygdala and middle temporal gyrus, while the three decreased clusters were inferior frontal gyrus, insula, and putamen. Follow-up connectivity analyses showed that these brain alterations were both task-specific and task-generic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite the lack of uniformity across task, such domain-specific and domain-general patterns of alterations provide a more nuanced understanding of the cognitive and affective deficits in Type 2 diabetes patients. This highlights the varied neuronal mechanisms underlying these deficits.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review","authors":"Alexandre Carpentier,&nbsp;Dimitrios Zampetas,&nbsp;Alexandre Durand,&nbsp;Mickael Naassila,&nbsp;Marie-Cécile Bralet","doi":"10.1002/brb3.70384","DOIUrl":"https://doi.org/10.1002/brb3.70384","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Patients with schizophrenia spectrum disorders (SSD), particularly patients with schizophrenia, have social cognitive impairments characterized by difficulties in emotion recognition, the ability to attribute mental states, explaining the causes of events, and identifying and utilizing social cues. These impairments appear from early life and are associated with poor functional and social prognosis. The origin of these impairments is not fully understood. The inflammatory hypothesis is one of the pathophysiological hypotheses of schizophrenia. Inflammatory marker abnormalities are also present in the early stages of schizophrenia and are associated with neuronal degeneration. Following our main hypothesis, the aim of this work was to conduct a review to explore the relationship between social cognition and inflammatory markers in SSD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The review included original studies reporting measures of social cognition and plasma levels of inflammatory markers in patients with SSD using the Pubmed, PsycINFO, and Embase databases. The PRISMA methodology was followed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eleven studies were selected and analyzed. They showed significant correlations between plasma cytokine levels and theory of mind and facial emotion recognition abilities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The correlations do not seem to be specific to social cognitive impairments, but our results support the hypothesis of a link between pro- and anti-inflammatory markers and cognition in SSD. In the future, other studies should be conducted to clarify this link from a diagnostic and therapeutic perspective: identification of inflammatory trait factors and patient subgroups and personalized anti-inflammatory therapies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic Dysregulation in Animal Models of Attention-Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms","authors":"Sarah Van Horn,&nbsp;Heather Driscoll,&nbsp;Donna J Toufexis","doi":"10.1002/brb3.70444","DOIUrl":"https://doi.org/10.1002/brb3.70444","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Attention-deficit-hyperactivity disorder (ADHD) is highly heritable and increases the likelihood of nicotine dependence (ND). The self-medication hypothesis of nicotine use in ADHD proposes that ADHD patients seek nicotine for its ability to improve their symptoms, and they have less success quitting, possibly due to the worsening of ADHD symptoms in withdrawal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The present analysis compared transcriptomic data from the brains of rodent models of ADHD and those of ND, with a focus on striatal gene expression. Differential expression analysis, pathway enrichment analysis, and gene-network mapping identified signaling networks and candidate genes that may contribute to the high co-occurrence between ADHD and ND.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified novel differentially expressed genes (<i>PRKAG2</i>, <i>MAPK1</i>), and genes with known associations to either ADHD or ND (<i>ANK3</i>, <i>CALD1</i>, <i>CHRNA4</i>, <i>CHRNA7</i>, <i>CMTM8</i>, <i>DLG4</i>, <i>DUSP6</i>, <i>GNG3</i>, <i>GNG11</i>, <i>GRIK5</i>, <i>GRINA2, GRM5</i>, <i>ICAM2</i>, <i>KCNJ6</i>, <i>PRKAB1</i>, <i>SNAP25</i>, <i>SYNPO</i>, <i>SYT1, VAMP2</i>). In addition, synaptic transmission (hsa04728, R-HAS-112315, R-HSA-442755) and MAPK signaling pathways (hsa04010, hsa04014, hsa04015, R-HSA-5673001, R-HSA-5684996) were enriched in both ADHD and ND.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The signaling pathways implicated by this analysis mediate neurological mechanisms known to contribute to ND. The association of analogous differently expressed genes and common signaling pathways suggests an important causal relationship between ND and ADHD that may be clinically important.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmenting the Global Layers of Malignant Meningioma: A Population-Based Study of Incidence, Risk Factors, and Temporal Trends","authors":"Junjie Huang,&nbsp;Lai Yim,&nbsp;Apurva Sawhney,&nbsp;Veeleah Lok,&nbsp;Lin Zhang,&nbsp;Xu Lin,&nbsp;Don Eliseo Lucero-Prisno III,&nbsp;Claire Chenwen Zhong,&nbsp;Wanghong Xu,&nbsp;Zhi-Jie Zheng,&nbsp;Mellissa Withers,&nbsp;Martin C. S. Wong","doi":"10.1002/brb3.70430","DOIUrl":"https://doi.org/10.1002/brb3.70430","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Malignant meningioma is a rare form of primary central nervous system cancer originating from the meninges membrane layers. Current data remain unmapped to cover trends for particular groups globally.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study examined the missing gap for its global burden, country-specific incidence, and risk factor trends, stratified by sex and age. Several databases were retrieved for temporal trend analysis and interpretation: Cancer incidence rates from five continents (CI5 Plus), global cancer observatory (GLOBOCAN), global burden of disease (GBD), and the world bank. association between malignant meningioma's and various factors was determined using linear regression. Meningioma incidence trends were estimated using the average annual percentage change (AAPC) with join point regression, including the shift in cancerous meningioma incidence based on corresponding specific variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>New malignant meningioma cases reported in 2020 were estimated to be 14,832 with aged-standardized rates (ASR) of 1.3 per million population. Considerable variations exist among nations for malignant meningioma's, with the highest ASR found in Latvia (6.9 per million population), compared to a 345-fold difference from the lowest ASR found in Fiji (0.02 per million population). Additionally, chronic disease presence such as smoking and hypertension was associated with higher malignant meningioma incidence. The analysis observed increasing rates of malignant meningioma in younger populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, this study contributes a global perspective on malignant meningioma incidence and emphasizes further investigation of specific groups that may have been overlooked. The increasing trend of malignant meningioma in younger populations warrants preventive, early diagnosis, and further research initiatives for evidence on risk management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Functional Connectivity in Nucleus Accumbens Subregions Associates With Cognitive Changes in Alzheimer's Disease","authors":"Lefan Yu,&nbsp;Mengmeng Feng,&nbsp;Yi Shang,&nbsp;Zhaohai Ren,&nbsp;Hanqi Xing,&nbsp;Yue Chang,&nbsp;Ke Dong,&nbsp;Yao Xiao,&nbsp;Hui Dai","doi":"10.1002/brb3.70440","DOIUrl":"https://doi.org/10.1002/brb3.70440","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>The nucleus accumbens (NAc), an important component of the reward circuit, is believed to play an indispensable role in Alzheimer's disease (AD). This study aimed to explore alterations in the functional connectivity (FC) of NAc subregions in AD patients and to explore their associations with neuropsychological profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Total 45 AD patients and 41 healthy controls (HCs) were recruited for this study. Four subregions of the NAc were used as regions of interest for whole-brain FC analysis. Correlation analyses were conducted to explore the relationships between the changed FC of brain regions with significant differences and neuropsychological profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with HCs, decreased FC was observed between NAc subregions and regions of the orbitofrontal cortex (OFC), precuneus (PCUN), insula (INS), cerebellum 8, and putamen in AD patients (Gaussian random field [GRF] corrected, voxel-level <i>p</i> &lt; 0.001, cluster-level <i>p</i> &lt; 0.05). Furthermore, the FC between the left core and left PCUN was correlated with the score of the auditory verbal learning test immediate recall task in AD patients (<i>r</i> = 0.441, <i>p</i> = 0.003, Bonferroni corrected).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Disruptions in connectivity between the NAc subregions and important cognitive-related areas may be related to the cognitive deficits observed in AD patients, especially episodic memory function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Persian Version of the College Academic Perfectionism Scale (CAPS)","authors":"Faezeh Peimanpak,&nbsp;Simin Hosseinian,&nbsp;Abbas Abdollahi","doi":"10.1002/brb3.70368","DOIUrl":"https://doi.org/10.1002/brb3.70368","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The College Academic Perfectionism Scale (CAPS) is a self-report 24-item questionnaire measuring perfectionism in academic and educational environments. The present study determined the psychometric properties of the CAPS among an Iranian sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The statistical sample consisted of students, 404 (115 females and 289 males) of whom were selected by nonrandomized convenience sampling to fill out the questionnaires.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Composite reliability and Cronbach alpha coefficient were used to examine the reliability and internal consistency of the CAPS, and the results revealed the appropriate internal consistency and composite reliability of the scale. Likewise, the face and content validities of the CAPS were evaluated and confirmed. Confirmatory factor analysis was also employed to determine and confirm construct and convergent validities. The analysis of the correlation showed that the CAPS positively and significantly correlated with self-efficacy, self-criticism, and perceived stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Generally, the results displayed that this scale enjoyed desirable psychometric properties in an Iranian sample and could be applied to Iranian samples confidently.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Center Experience on Endovascular Treatment of Occlusion and/or Stenosis of Bilateral Carotid Arteries","authors":"Şule Dalkiliç,&nbsp;Sena Boncuk Ulaş,&nbsp;Levent Avci,&nbsp;Beyza Nur Bozkurt,&nbsp;Alihan Abdullah Akbaş,&nbsp;Vasfiye Sezer,&nbsp;Esra Ünal,&nbsp;Ayşe Kristina Polat,&nbsp;Semanur Aksu,&nbsp;Derya Kara Genç,&nbsp;Halil Alper Eryilmaz,&nbsp;Türkan Acar,&nbsp;Yeşim Guzey Aras,&nbsp;Bilgehan Atilgan Acar","doi":"10.1002/brb3.70395","DOIUrl":"https://doi.org/10.1002/brb3.70395","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Carotid artery stenosis is the presence of 50% or more stenosis in the internal carotid artery (ICA) according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria and is one of the leading etiological factors of ischemic stroke. The severity of stenosis is associated with stroke risk. The prevalence of bilateral carotid artery stenosis (BCAS) varies. This study aims to evaluate the clinical outcomes and complications associated with carotid artery stenting in patients with BCAS or occlusion in a comprehensive stroke center.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The data of patients who underwent carotid artery stenting (CAS) between January 2020 and September 2024 were scanned. The demographic data and comorbidities were noted from the patients’ files. Then, the patients were divided into two groups. The first group is “bilateral 50%–99% ICA stenosis” and the second group is “one side ICA occluded contralateral side ICA ≥50% stenosis”. Both groups were also listed as symptomatic and asymptomatic. Demographic and endovascular procedure data were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 82 patients were included in this study, 69 male (84.14%) and 13 female (15.85%). The mean age was 69.46 ± 7.24. Hypertension (HT) was the most common comorbid disease (69.51%). Sixty-six patients (80.50%) were symptomatic and 16 (19.50%) were asymptomatic. TIA developed in one patient in the first group. Two minor (The National Institutes of Health Stroke Scale [NIHSS] 1–3) and two major strokes developed in the second group. Only three patients (two in the first group, one in the second group) underwent postdilatation balloon angioplasty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Endovascular treatment seems to be an acceptable strategy in comprehensive stroke centers where the possible complication risks can be well managed in this group of patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESENA: A Novel Spatiotemporal Event Network Information Approach for Mining Scalp EEG Data","authors":"Qiwei Dong,&nbsp;Runchen Yang,&nbsp;Xinrui Wang,&nbsp;Zongwen Feng,&nbsp;Chenggan Liu,&nbsp;Shiyu Chen,&nbsp;Yuxi Zhou,&nbsp;Dezhong Yao,&nbsp;Junru Ren,&nbsp;Qi Xu,&nbsp;Li Dong","doi":"10.1002/brb3.70426","DOIUrl":"https://doi.org/10.1002/brb3.70426","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Brain activity possesses unique spatiotemporal characteristics. However, few electroencephalogram (EEG) analysis methods were designed to capture these features. Here, we developed a novel approach to mine spatiotemporal information contained in EEG data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this work, a novel approach, named EEG Spatiotemporal Event Network Analysis (ESENA), was proposed to fully capture the complex spatiotemporal patterns of EEG data during rich and complex stimulations. The essence of this method is to map power events onto network nodes and define connections on the basis of the temporal sequence of these events, thereby establishing a spatiotemporal network structure. Next, the performance and feasibility of ESENA were tested using three resting-state and game-playing state EEG datasets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For eyes-closed resting-state EEG, specific patterns of spatiotemporal event networks (SENs) were revealed by ESENA for different frequency bands, and the links between SENs were mainly located in regions of rhythmic activity revealed by the relative power spectrum. In the comparison between eyes-closed and eyes-open resting-state EEG, ESENA provided additional important spatiotemporal information in the delta frequency band in the frontal lobe, and in the theta frequency band in the frontoparietal lobes. In the comparison between the game-playing state and eyes-closed resting-state EEG, spatiotemporal information in the delta frequency band in the frontoparietal lobes, the theta frequency band in the parietotemporal lobe and the alpha frequency band in the occipitoparietal lobes was additionally uncovered by ESENA. Moreover, these SENs were correlated with behavioral data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings demonstrated that the proposed ESENA method is superior to traditional EEG methods in discovering spatiotemporal patterns from EEG data and has the potential to become an important tool providing deeper insights into the brain's complex networks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}