Brain and Behavior最新文献

{"title":"Determining the Effects of Emotional Freedom Techniques on Sexual Dysfunction and Self-Care Management in Women Diagnosed With Multiple Sclerosis","authors":"Ayşe Çuvadar,&nbsp;Ayfer Güneş,&nbsp;Yeter Çuvadar Baş,&nbsp;Sezgin Kehaya","doi":"10.1002/brb3.70635","DOIUrl":"https://doi.org/10.1002/brb3.70635","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to determine the effects of Emotional Freedom Techniques (EFT) on sexual dysfunction and self-care in women diagnosed with multiple sclerosis (MS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This study was conducted using a pretest–posttest experimental design, including follow-up assessments to evaluate the sustainability of the intervention effects. The sample consisted of 16 women aged between 19 and 49 years who were diagnosed with MS and presented to the neurology clinic of a university hospital in Türkiye between October 2023 and September 2024. Data collection instruments included the Personal Information Form (PIF), Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19), and Self-Care Management Process in Chronic Illness (SCMP-G). Repeated measures analysis of variance (ANOVA) was employed to analyze changes in sexuality and self-care over time. Statistical significance was set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants received two EFT sessions per month, each lasting 60 min, together with affirmation sessions conducted at least twice a week for 10–15 min. The mean scores of all subdimensions of the MSISQ-19 reached the lowest levels by the seventh week following EFT intervention, with significant differences between time points (<i>p</i> &lt; 0.05). Even though an improvement was observed in the social protection dimension of self-care, the mean scores for the self-protection subdimension decreased.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The application of EFT demonstrated positive effects on sexual functioning and self-care levels in women with MS. Therefore, EFT can be integrated into the holistic care processes of patients with MS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making Sense of Proprioception by Bibliometric Research","authors":"Kevser Sevik Kacmaz","doi":"10.1002/brb3.70610","DOIUrl":"https://doi.org/10.1002/brb3.70610","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Proprioception is one of the most significant factors in balance, stability, fine movements, coordination, and injury prevention. Proprioception research helps clarify how the nervous system integrates sensory inputs to plan and execute movements. Bibliometric analyses offer a systematic and comprehensive understanding of a field's structure, evolution, trends, research clusters, and gaps, laying a scientific foundation for future research. This study employs bibliometric analysis to provide a panoramic view of proprioception research and to identify its thematic structure, evolution, production, and impact.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 4506 original studies from 1979 to 2024 were extracted from the WoS. Using the Bibliometrix application in RStudio, a bibliometric analysis examined scientific performance, production, citation impact, research trends, developments, and the conceptual framework related to proprioception research. The Biblioshiny application performed the scientific mapping.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Proprioception research has increased linearly. The most influential article was Sensorimotor System Measurement Techniques, published in the Journal of Athletic Training, with 455 citations. Uwe Proske was the most influential author, with an &lt;i&gt;h&lt;/i&gt;-index of 20 in proprioception. The literature utilized 6797 keywords. Of these, 29% was proprioception, 4% joint position sense, and 4% rehabilitation. Keyword trends showed a shift toward rehabilitation and neurophysiology, with terms such as “rehabilitation,” “balance,” and “stroke” becoming more prevalent. However, an emerging interest in psychophysics, which investigates the interaction between proprioception and sensory perception, is also evident. This theme offers significant opportunities for future research. The USA leads in productivity, contributing 57.70% of the total publications, followed by Canada with 19.32%, and the UK with 18.28%.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The results indicate a significant upward trend in research output, highlighting the increasing importance of proprioception in clinical and research settings. The findings emphasize several gaps in current proprioception research, including the need for greater interdisciplinary collaboration, particularly with neuroprosthetics and AI-driven proprioceptive modeling. Furthermore, geographical diversity in research, particularly from underrepresented regions, is critical for comprehensively understanding propri","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70610","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory Processing Difficulties in Children With Eosinophilic Esophagitis","authors":"Muserrefe Nur Keles,&nbsp;Hacer Ilbilge Ertoy Karagol,&nbsp;Ramazan Yildiz,&nbsp;Odul Egritas Gurkan,&nbsp;Sinan Sari,&nbsp;Bulent Elbasan,&nbsp;Buket Dalgic,&nbsp;Arzu Bakirtas,&nbsp;Gazi University Pediatric Eosinophilic Gastrointestinal Diseases Working Group","doi":"10.1002/brb3.70642","DOIUrl":"https://doi.org/10.1002/brb3.70642","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease associated with dysphagia, food impaction, feeding difficulties, vomiting, and failure to thrive in children. These symptoms result from dysregulated neural control and inflammation-induced tissue remodeling and may extend beyond esophageal dysfunction to impact sensory processing. This study aimed to evaluate the sensory processing difficulties in children with EoE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective case-control study included children with EoE and age-matched healthy controls. Sociodemographic data and medical histories were collected. Sensory processing abilities were evaluated using the sensory profile, which evaluates sensory performance across multiple domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 69 children aged 3–10 years participated in the study, including 22 diagnosed with EoE and 47 healthy controls. No significant demographic differences were found between groups (<i>p</i> &gt; 0.05). Children with EoE exhibited significantly greater sensory processing difficulties in oral sensory processing, vestibular processing, and oral sensory sensitivity compared to healthy controls (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Sensory processing difficulties in children with EoE extend beyond feeding challenges, affecting oral sensory and vestibular processing functions. Incorporating sensory processing assessments into clinical evaluations may improve the understanding of sensory-related challenges in this population. A multidisciplinary approach could help refine clinical management strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Marathon Enthusiast Engagement Through AI: A Quantitative Study on the Role of Social Media in Sports Communication","authors":"Wei Cheng,&nbsp;Yu Tian,&nbsp;Meng Na","doi":"10.1002/brb3.70593","DOIUrl":"https://doi.org/10.1002/brb3.70593","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study explores the impact of AI-driven personalization, interactive features, and real-time feedback on user engagement and experience among marathon enthusiasts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>By integrating uses and gratifications theory (UGT), self-determination theory (SDT), and the technology acceptance model (TAM), the research examines how these AI-driven elements influence user behavior on marathon-related social media platforms. A quantitative approach using partial least squares structural equation modeling (PLS-SEM) was applied to data from 400 Chinese marathon enthusiasts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>The findings reveal that AI-driven personalized content significantly enhances user engagement and experience, with user engagement partially mediating this relationship. Interactive features are crucial for building a sense of community but have a less direct impact on user experience. Real-time feedback significantly improves user engagement, particularly for users with higher technological proficiency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This research contributes to the understanding of user engagement in AI-enhanced environments and provides practical insights for designing more personalized and interactive platforms for marathon enthusiasts. Future studies should explore the long-term effects, cultural factors, and ethical considerations of AI-driven personalization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Large-Scale Brain Network Abnormalities in Patients With Beta-Thalassemia","authors":"Mingrui Yang,&nbsp;Guowei Chen,&nbsp;Peng Peng,&nbsp;Cheng Tang,&nbsp;Chaotian Luo,&nbsp;Fei Peng,&nbsp;Rong Kong,&nbsp;Chunxia Zhu,&nbsp;Jiatong Liang","doi":"10.1002/brb3.70614","DOIUrl":"https://doi.org/10.1002/brb3.70614","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Beta-thalassemia major (β-TM) is a hereditary blood disorder characterized by chronic anemia and hypoxia, which may have profound effects on brain function. This study systematically evaluates alterations in both intra-brain network functional connectivity (FC) and inter-network functional connectivity (FNC) in β-TM patients using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), aiming to uncover the potential mechanisms underlying their neurofunctional impairments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 72 β-TM patients and 50 age- and gender-matched healthy controls (HC). rs-fMRI was used to collect brain functional data, and ICA was applied to extract 14 resting-state functional networks (RSNs). Differences in FC within networks and FNC between the two groups were further compared to investigate the brain network abnormalities in β-TM patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In β-TM patients, FC within brain networks was significantly reduced in the anterior default mode network (aDMN), posterior default mode network (pDMN), left frontoparietal network (lFPN), right frontoparietal network (rFPN), ventral attention network (VAN), and executive control network (ECN). In contrast, FC was significantly increased in the dorsal sensorimotor network (dSMN) and posterior visual network (pVN). FNC analysis revealed that β-TM patients exhibited enhanced connectivity between the lFPN and rFPN, as well as between the dorsal attention network (DAN) and VAN. However, connectivity was significantly weakened between the DAN and lFPN, ECN, auditory network (AN), and salience network (SN); as well as between the pVN and dSMN. These findings suggest impairments in cognitive control, attention allocation, and sensory integration, with specific disruptions in the SN that may contribute to the observed dysfunctions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Brain network abnormalities in β-TM patients manifest as an alternating pattern of enhanced and weakened connectivity, revealing the profound impact of chronic anemia and hypoxia on cognitive, emotional, and sensory functions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta–Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia","authors":"Ying Wang,&nbsp;Jiajia Zhang,&nbsp;Xuan Huang,&nbsp;Shujian Huang,&nbsp;Yanmei Feng,&nbsp;Haibo Shi,&nbsp;Hui Wang,&nbsp;Richard Salvi,&nbsp;Shankai Yin","doi":"10.1002/brb3.70437","DOIUrl":"https://doi.org/10.1002/brb3.70437","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The phantom sound of tinnitus can be an extremely debilitating condition. The thalamocortical dysrhythmia (TCD) hypothesis is a feature of subjective tinnitus; however, its consistency in characterizing different types of tinnitus remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We compared theta–beta/gamma coupling in multichannel EEG recordings from subjects with bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and healthy controls (HC). Additionally, we used these EEG features to distinguish BT from NBT by employing the k-nearest neighbor (KNN) model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Theta–beta/gamma phase-amplitude coupling (PAC) was enhanced in the auditory cortex of both BT and NBT groups compared to HC. In contrast, theta–beta/gamma PAC was specifically enhanced in the cingulate gyrus and parahippocampal gyrus in the BT group. Notably, theta–gamma PAC in the orbitofrontal cortex was attenuated in the BT group and showed a negative correlation with their THI scores. By integrating theta–beta/gamma PAC into a machine learning algorithm, up to 92% of BT patients were accurately identified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TCD in BT patients was characterized by enhanced theta–beta/gamma PAC in the auditory cortex, cingulate gyrus, and parahippocampal gyrus and attenuated theta–gamma PAC in the orbitofrontal cortex. The latter was significantly negatively correlated with THI scores. These PAC features, which could objectively distinguish BT patients by machine learning, may support the specificity of PAC features in tinnitus characterization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional and Structural Differences of Brain in Patients With Vestibular Migraine: A Resting-State Functional MRI and DTI Study","authors":"Ni Liu,&nbsp;Qijun Yu,&nbsp;Shaowei Gan,&nbsp;Yonghui Pan,&nbsp;Zhaowen Qiu","doi":"10.1002/brb3.70569","DOIUrl":"https://doi.org/10.1002/brb3.70569","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The pathogenesis of vestibular migraine (VM) still remained unclear. This study used functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) techniques to study the characteristics of VM brain structure and function changes, to explore the association between those changes and clinical symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>13 VM patients and 12 migraineurs were recruited from a tertiary hospital, while 9 healthy people were selected as controls (HC). All subjects were scanned with fMRI and DTI. The image data were analysed by local consistency (ReHo), functional connectivity (FC), and spatial statistical method based on fiber tracking (TBSS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the migraine group, ReHo in the right dorsolateral middle frontal gyrus, the right inferior frontal gyrus of the insula, and the right inferior frontal gyrus of the trigone in the VM group increased, while the left lingual gyrus, the left posterior cerebellum, and the left fusiform gyrus decreased, and the whole brain FC of the right inferior frontal gyrus in VM group was lower than that in the left middle cingulate gyrus, and lower in the posterior cerebellum than that in the cingulate gyrus. ReHo in the left middle occipital gyrus and left middle temporal gyrus decreased in the VM group compared to the HC group. However, no differences among the three groups were found in DTI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There may be vestibular multisensory processing abnormalities in patients with VM, while the regulation of cerebellum may be an important role. fMRI detection may open a new sight for VM diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Education Levels and Sedentary Behavior With Depression Among US Adults","authors":"Chun Yang,&nbsp;Tiankuo Gao,&nbsp;Yichen Zhang,&nbsp;Cuicui Feng,&nbsp;Kai Zhang","doi":"10.1002/brb3.70615","DOIUrl":"https://doi.org/10.1002/brb3.70615","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Earlier studies have proposed the effect of education level and sedentary behavior (SB) on the incidence of depression in adults. However, the association between the combination of education level and SB and depression in adults has not yet been investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study population consisted of US adults (aged ≥18 years) who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. A multivariable logistic regression model was employed to assess the association between education level, SB, and depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 29,822 participants (weighted mean [SE] age, 47.9[0.2] years; 51.2% male) in our study cohort. Depression was negatively linked to the higher education level (adjusted OR = 0.68 [95% CI: 0.57–0.81], Model 4) and positively correlated to higher SB (adjusted OR = 1.58 [95% CI: 1.34–1.87]). The ORs [95% CIs] for depression were 1.40 [1.13–1.74], 1.68 [1.20–2.35], and 1.78 [1.42–2.22], respectively, among lower education groups sitting &lt; 6 h a day (h/d), 6–8 h/d and ≥ 8 h/d compared with higher education/ sitting &lt; 6 h/d groups (Model 3). Among participants with higher education, those who engaged in SB ≥ 8 h/d had a 1.53-fold [95% CI, 1.31–1.79] increased risk of depression compared with those who sat for &lt;6 h/d (<i>p</i> &lt; 0.0001; Model 4).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A lower education level and prolonged SB are independently and jointly associated with an increased risk of depression. Interventions that aim to reduce SB, especially among those with lower educational levels and also among those with higher educational levels who sit for more than 8 h per day, may help reduce the prevalence of depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke in High-Altitude Areas","authors":"Chuanxi Duan,&nbsp;Lijun Wu,&nbsp;Yuding Luo,&nbsp;Jiali Zhang,&nbsp;Pingchuan Liu,&nbsp;Fanzhou Ren,&nbsp;Junhao Li,&nbsp;Hai Xiong,&nbsp;Jian Wang","doi":"10.1002/brb3.70626","DOIUrl":"https://doi.org/10.1002/brb3.70626","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Stroke poses a significant social and familial burden on populations worldwide. While research on stroke in low-altitude areas is extensive, there remains a considerable gap in stroke research in high-altitude regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A computer-based search of PubMed and Google Scholar was conducted to retrieve literature on stroke in high-altitude areas. Cross-referencing was performed using available articles and other scientific search engines. Relevant studies on stroke in high-altitude regions were included in this review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of five review articles, two systematic reviews and meta-analyses, three cross-sectional studies, nine retrospective clinical studies (including case reports and case-control studies), one commentary, one letter, and three animal studies were included in this literature review. All data were sourced from high-altitude regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We explored the contribution of environmental and individual factors in high-altitude areas to the occurrence and progression of stroke, and highlighted the current research advances in ischemic stroke, hemorrhagic stroke, post-stroke cognitive impairment in high-altitude regions, and flight-related stroke. In light of the current limitations in research on stroke in these areas, we propose feasible directions for future studies, aiming to provide insights for future research on stroke in high-altitude regions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70626","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Blood Microbiome in Parkinson's Disease, Schizophrenia, and Posttraumatic Stress Disorder","authors":"C. Rust,&nbsp;D. Tonge,&nbsp;L. L. van den Heuvel,&nbsp;L. Asmal,&nbsp;J. Carr,&nbsp;E. Pretorius,&nbsp;S. Seedat,&nbsp;S. M. J. Hemmings","doi":"10.1002/brb3.70629","DOIUrl":"https://doi.org/10.1002/brb3.70629","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Recent studies have challenged the idea of sterile blood, suggesting the presence of a blood microbiome. The detection of microbial nucleic acids in blood is thought to reflect the status of distant microbial niches, including the gut. However, the origins and viability of these microbes remain debated. In this study, blood microbiome signatures in Parkinson's disease (PD), schizophrenia (SCZ), and posttraumatic stress disorder (PTSD) were evaluated by extracting RNA-sequencing (RNA-seq) reads that did not map to the human genome. Furthermore, we investigated the correlation between the gut and blood microbiome in PD, SCZ, and PTSD to gain insight into possible mechanisms behind disease etiology.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We used whole-blood samples from PD (cases: &lt;i&gt;n&lt;/i&gt; = 14; controls: &lt;i&gt;n&lt;/i&gt; = 19), SCZ (cases: &lt;i&gt;n&lt;/i&gt; = 17; controls: &lt;i&gt;n&lt;/i&gt; = 22), and PTSD (cases: &lt;i&gt;n&lt;/i&gt; = 45; trauma-exposed [TE] controls: &lt;i&gt;n&lt;/i&gt; = 34) cohorts. The RNA paired-end sequence reads that did not map to the human reference genome (hg38/GRCH38) were isolated using the sequence alignment/map tools (SAMtools). These unmapped reads were classified against known archaeal, bacterial, and viral microbial genomes using &lt;i&gt;Kraken2&lt;/i&gt; (v2.1.3; k2_standard_08gb_20240112.taz.gz database), and further taxa abundances were estimated using &lt;i&gt;Bracken&lt;/i&gt; (v2.9). The differential abundance of blood microbial signatures between case-control groups for each cohort was assessed using &lt;i&gt;DESeq2&lt;/i&gt; (v1.38.3). Each cohort was analyzed separately.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Statistically significant differences in the abundance of &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; and &lt;i&gt;Acinetobacter wuhouensis&lt;/i&gt; in PD and &lt;i&gt;Salmonella enterica&lt;/i&gt;, &lt;i&gt;Staphylococcus aureus&lt;/i&gt;, &lt;i&gt;Pseudomonas&lt;/i&gt; sp. CC6-YY-74, and &lt;i&gt;Shinella sumterensis&lt;/i&gt; in SCZ were observed compared to cohort-specific controls. We observed no statistically significant differences in microbial signatures between PTSD cases and controls.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We found blood microbial signatures associated with PD and SCZ; however, no significant blood microbial signature was observed for PTSD. These results should be interpreted with caution as biases may have been introduced due to low concentrations of microbial signatures. Further research is required to understand the biological implications of these findings, in particular, taking into account the repurposed data source, and the potential for contamination (duri","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}