Brain and Behavior最新文献

{"title":"Community Participation in Native American and White Individuals After Traumatic Brain Injury: A 5-Year Longitudinal Model Systems Study.","authors":"Jack D Watson, Paul B Perrin, Bridget Xia, Juan Carlos Arango-Lasprilla","doi":"10.1002/brb3.70195","DOIUrl":"10.1002/brb3.70195","url":null,"abstract":"<p><strong>Purpose/objective: </strong>This study examined (a) differences in demographic and injury-related characteristics following traumatic brain injury (TBI) between Native American and White individuals; (b) differences in community participation between Native American and White individuals with TBI at 1, 2, and 5 years after TBI; and (c) whether demographic or injury-related characteristics account for community participation disparities.</p><p><strong>Research method/design: </strong>A sample of 63 Native American individuals demographically matched to 63 White individuals (n = 126) was enrolled while on acute rehabilitation for moderate or severe TBI. Baseline demographic and injury-related characteristics were collected at this time and the Participation Assessment with Recombined Tools (PART-O) measure of community participation at 1, 2, and 5 years after TBI.</p><p><strong>Results: </strong>Native American individuals were less likely to have private insurance and be employed at the time of injury and more likely to have had lower educational attainment and engaged in binge drinking in the month prior to TBI compared to White individuals. Native American individuals demonstrated lower Out and About scores but statistically equivalent Social and Productivity scores. The difference in Out and About scores did not change as a function of time, and the overall difference between the two groups dissipated with the inclusion of statistically different sociodemographic variables.</p><p><strong>Conclusions/implications: </strong>Clinicians can provide culturally sensitive, patient- and family-centered care by conducting comprehensive interviews and identifying strengths as well as risk factors that enhance or hinder community participation after TBI in Native American individuals.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 12","pages":"e70195"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial of Mindfulness Meditation Combined With BrainLink Intelligent Biofeedback Instrument on Pancreatic Cancer Patients Under Chemotherapy.","authors":"Na Mi, Shu-Ting Zhang, Xiao-Li Sun, Ting Li, Yu Liao, Lei Dong, Ling-Ling Chu","doi":"10.1002/brb3.70197","DOIUrl":"https://doi.org/10.1002/brb3.70197","url":null,"abstract":"<p><strong>Background: </strong>Adjuvant chemotherapy can promote the 5-year overall survival rate of pancreatic cancer (PC) patients to 16%-21%. However, the negative emotions of patients, such as anxiety, are usually omitted. Moreover, their disease burden concentrates on pain symptoms, seriously affecting the quality of life of patients. How to improve the negative emotions of PC patients, alleviate their pain, and ameliorate their quality of life has become an urgent issue.</p><p><strong>Objective: </strong>To explore the effect of mindfulness meditation (MM) combined with the BrainLink intelligent biofeedback instrument on the anxiety, pain, brain fatigue, and quality of life of PC patients under chemotherapy.</p><p><strong>Method: </strong>A total of 145 PC patients under chemotherapy were admitted to the Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Army Military Medical University from January 2022 to March 2024 and were incorporated as study objects. They were divided into a control group (n = 72) and a test group (n = 73) according to the random number table. The control group received routine nursing treatment; the experimental group was treated with MM combined with an intelligent biofeedback instrument. The general information, anxiety (SAS), pain (VAS), EEG signal data (degrees of fatigue, concentration, and relaxation and EEG waves), and quality of life (EORTC QLQ-C30) of the two groups before intervention and 4th, 8th, and 12th weeks after intervention were compared.</p><p><strong>Result: </strong>There is no significant difference in baseline data and pathological features between the two groups. After the 4th, 8th, and 12th weeks of intervention, the SAS values of the experimental group are remarkably lower than those of the control group (p < 0.05). In the 4th, 8th, and 12th weeks of intervention, the VAS scores of the experimental group are apparently lower than those of the control group (p < 0.05). In the 4th, 8th, and 12th weeks of intervention, the score of the quality of life (EORTC QLQ-C30) in the experimental group is significantly higher than that in the control group (p < 0.05). In the 4th, 8th, and 12th weeks, compared with the control group, the experimental group patients showed significant improvement in brain fatigue relief, concentration, and relaxation levels (p < 0.05), while the experimental group's brain α and θ. The wave showed an upward trend (p < 0.05).</p><p><strong>Conclusion: </strong>MM combined with the BrainLink intelligent biofeedback instrument can significantly mitigate the anxiety, pain severity, and brain fatigue relief degree of PC patients under chemotherapy, thereby promoting their quality of life. It provides a novel intervention for the psychosomatic health of PC patients under chemotherapy.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 12","pages":"e70197"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of Neutrophil Percentage-to-Albumin Ratio With Stroke: Evidence From NHANES 1999-2020.","authors":"Shuying Xu, Yiyan Sun, Siyao Zhang, Yongjun Peng, Dechun Dai, Leiyong Zhao","doi":"10.1002/brb3.70192","DOIUrl":"https://doi.org/10.1002/brb3.70192","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this research is to examine the association between neutrophil percentage-to-albumin ratio (NPAR) and stroke, providing a reference for the prevention and prognosis of clinical stroke.</p><p><strong>Method: </strong>The study included 56,566 participants from the National Health and Nutrition Examination Survey (NHANES) to explore the association between NPAR and stroke using logistic regression and restricted cubic splines. Upon identifying the nonlinear relationship, inflection points were calculated using recursive algorithms and two-stage linear regression models. Stratified analyses and interaction tests examined variations across population groups.</p><p><strong>Results: </strong>After adjusting for confounders, NPAR was positively associated with stroke (OR: 1.09, 95% CI: 1.05-1.12). Restricted cubic spline analysis indicated a nonlinear trend. Beyond the inflection point, the increasing trend of stroke incidence with higher NPAR levels began to slow down. This relationship remained nonlinear in males but was linear in females.</p><p><strong>Conclusion: </strong>This study revealed a nonlinear positive association between NPAR and stroke, with higher NPAR increasing the risk of stroke.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 12","pages":"e70192"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and Validity of the Turkish Version of the Acute Stroke Management Questionnaire.","authors":"Öznur Adadıoğlu, Bilgehan Atılgan Acar, Türkan Acar","doi":"10.1002/brb3.70191","DOIUrl":"https://doi.org/10.1002/brb3.70191","url":null,"abstract":"<p><strong>Objective: </strong>The current research was carried out to test the validity and reliability of the Turkish version of the Acute Stroke Management Questionnaire (ASMaQ), developed to determine the acute stroke management awareness of health-care professionals.</p><p><strong>Methods: </strong>This methodological study was performed in a training and research hospital. Data were collected using the \"Participant Interview Form\" and the Acute Stroke Management Questionnaire.</p><p><strong>Results: </strong>The Content Validity Index (CVI) of the Acute Stroke Management Questionnaire was found to be 0.91. As a result of exploratory factor analysis (EFA), it was revealed that the scale, which was adapted to Turkish, consisted of 3-factor and 29 items, as in its original form. Confirmatory factor analysis confirmed the 3-factor structure of the scale. The ASMaQ exhibited strong internal consistency (Cronbach's alpha 0.96) and test-retest reliability (0.879).</p><p><strong>Conclusion: </strong>The 29-item and three-dimensional structure of the Acute Stroke Management Questionnaire was revealed to be a valid and reliable measurement tool that could be utilized in evaluating the acute stroke management awareness of health-care professionals in the Turkish language and culture.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 12","pages":"e70191"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Neurofeedback Interventions for Attention-Deficit/Hyperactivity Disorder in Children: A Network Meta-Analysis.","authors":"Gang Wu, Qiang He, Da Li, Zhang Zhang, Jinli Miao, Yanping Shu","doi":"10.1002/brb3.70194","DOIUrl":"https://doi.org/10.1002/brb3.70194","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to synthesize and encapsulate findings from recent research (May 1, 2018 to August 1, 2023) on neurofeedback interventions for children diagnosed with attention deficit hyperactivity disorder (ADHD).</p><p><strong>Methods: </strong>A comprehensive search was conducted across major databases and platforms, including randomized controlled trials s focusing on children aged 5-11 years with ADHD. The inclusion was broad, not restricted by ADHD subtype, gender, IQ, socioeconomic status, or coexisting conditions.</p><p><strong>Results: </strong>From the study screening process, 13 studies were included in the network meta-analysis, involving 1370 children. Most neurofeedback therapies surpassed placebo in ADHD symptoms. In the acceptability outcome, five neurofeedback therapies (HEG, SCP training, TBR training, SMR training, and active control) outperformed the inactive control, physical activity, and EMG therapies.</p><p><strong>Conclusions: </strong>The potential efficacy of nonpharmacological interventions in ADHD management among children is illuminated. The findings advocate for a holistic, child-centered approach, emphasizing the need for further in-depth research to understand and refine these interventions.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 12","pages":"e70194"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Antagonism Hypothesis: A New View on the Emergence of Consciousness.","authors":"Weirui Xiong, Lu Yu","doi":"10.1002/brb3.70201","DOIUrl":"https://doi.org/10.1002/brb3.70201","url":null,"abstract":"<p><strong>Purpose: </strong>The generation of consciousness poses a complex scientific challenge. Neuroscience and biological sciences have extensively studied this phenomenon, yielding numerous theories and hypotheses. However, to date, no reliable evidence has emerged to exclude any hypothesis conclusively, nor has any theory garnered unanimous agreement. This study aims to offer novel insights for further in-depth study on consciousness.</p><p><strong>Method: </strong>A new theoretical hypothesis was proposed based on reviews and comments from predictive processing theory, information theory, thermodynamics, and neuroscience.</p><p><strong>Findings: </strong>This study argues that, first, it is necessary to clarify that the core implication of the concept of consciousness is first-person perception. Accordingly, the study of consciousness is based on this premise. Second, on this basis, the antagonistic hypothesis of consciousness generation was proposed. This hypothesis holds that consciousness arises from the antagonism of mature individual experiences that cannot be seamlessly integrated with the function of addressing and navigating these conflicts.</p><p><strong>Conclusion: </strong>The antagonism hypothesis is a new concept regarding the generation of consciousness that deserves further study.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 12","pages":"e70201"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perineuronal Nets in Syrian Hamsters: Anatomical Localization, Sex Differences, Diurnal Variation, and Response to Social Stress.","authors":"Emma K Shaughnessy, Benjamin W Horne, Kim L Huhman","doi":"10.1002/brb3.70189","DOIUrl":"https://doi.org/10.1002/brb3.70189","url":null,"abstract":"<p><strong>Purpose: </strong>Perineuronal nets (PNNs) are extracellular matrix proteoglycans surrounding neurons and glia. It has been suggested that PNNs are involved in the pathophysiology of multiple CNS illnesses, including stress-related neuropsychiatric disorders like schizophrenia, major depressive disorder, and anxiety disorders.</p><p><strong>Method: </strong>Before examining the putative role of PNNs in stress-related responses, we described for the first time the anatomical distribution in Syrian hamsters (Mesocricetus auratus), an excellent model organism for studying social stress and circadian rhythms.</p><p><strong>Results: </strong>We observed PNNs throughout the hamster cortex and hippocampus but found low to no expression in subcortical regions such as the hypothalamus, thalamus, and striatum, sites where they are observed in rats and mice. We further demonstrated that PNNs are dynamically regulated in a sex-dependent manner in response to acute social stress, specifically in hippocampal area CA1. We did not observe a difference in PNNs between the beginning of the dark versus light phase of the light-dark cycle in hamsters, despite other laboratory rodents showing diurnal variation in PNNs. Finally, we also demonstrated that there are sex differences in PNN expression in the somatosensory cortex and the basolateral amygdala in hamsters, suggesting that sex as a biological variable should be considered in studies of PNN function.</p><p><strong>Conclusion: </strong>Together, the data from the current study suggest that a comparative approach will be necessary to fully elucidate the functional role of PNNs and, further, that Syrian hamsters are a valuable model in this endeavor.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 12","pages":"e70189"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Cognitive Function and Emotion, Sleep, Frailty, and Nutrition in Hospitalized Patients","authors":"Nan Wang,&nbsp;Qunying Zhang,&nbsp;Peng Li,&nbsp;Lilan Guo,&nbsp;Xiaoman Wu,&nbsp;Qiuyun Tu","doi":"10.1002/brb3.70170","DOIUrl":"10.1002/brb3.70170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>With the rapid increase in China's aging population, cognitive impairment in the elderly has become a significant public health issue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>In this study we performed a cross-sectional analysis to comprehensively investigate the relationship between cognitive function and emotion, sleep, frailty, nutrition, and clinical variables in hospitalized geriatric patients according to age group and sex. We determined the most important risk factors for cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 1121 inpatients were recruited from the Department of Gerontology at the Fifth Affiliated Hospital of Sun Yat-sen University, China, from August 2023 to April 2024. Cognitive assessment was performed using the Mini-Mental State Examination scale and Montreal Cognitive Assessment. The sleep quality was evaluated based on the Pittsburgh Sleep Quality Index, and anxiety and depression were evaluated based on the Hamilton Anxiety Scale and Hamilton Depression Scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sex and age differences existed with respect to cognition, emotion, and sleep quality. After full adjustment, age, education level, working status, hemoglobin level, activities of daily living, Hamilton Depression Scale, and Pittsburgh Sleep Quality Index scores were significantly and independently associated with cognitive impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Geriatric patients with a better mood, sleep and nutrition status, higher education level, and more social engagement performance had superior cognitive function. Interventions, such as valuing education, improving sleep, relaxing emotions, preventing anemia, and adjusting lifestyle, may help prevent the development of cognitive deficits. Elderly and female patients required special attention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Various factors were shown to contribute to maintenance of cognitive function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 11","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting Causal Links Between Gut Microbiota, Inflammatory Cytokines, and Parkinson's Disease: A Mendelian Randomization Study","authors":"Ma Caiyun,&nbsp;Wen Hebao,&nbsp;Ye Wenhao,&nbsp;Liu Changqing,&nbsp;Li Changqing,&nbsp;Zhao Xiaojiang","doi":"10.1002/brb3.70169","DOIUrl":"10.1002/brb3.70169","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The association between gut microbiota (GM) and Parkinson's disease (PD) has been well established, but whether there is a causal relationship between the two and whether inflammatory cytokines (ICs) act as mediators remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods:</h3>\u0000 \u0000 <p>We utilized the summary databases of large-scale genome-wide association studies (GWAS) conducting Mendelian randomization (MR) analyses to investigate the causal relationships between GM, ICs, and PD. The inverse-variance weighted (IVW) method was primarily used to identify GM and ICs associated with PD and to examine the mediating role of ICs, supplemented by MR Egger and weighted median.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results:</h3>\u0000 \u0000 <p>Through MR analysis, we identified three positive causal relationships and six negative causal relationships between GM and PD. Additionally, there were three positive associations and five negative associations between ICs and PD. However, after adjusting for FDR, none of these associations were significant. In reverse MR analysis, we also found causal relationships between PD and various GM and ICs. Further, two-step MR analysis indicated that the negative impact of phylum Actinobacteria on PD may be mediated through Fms-related tyrosine kinase 3 ligand levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion:</h3>\u0000 \u0000 <p>This study strengthens the link between GM and the risk of PD, while also revealing the potential mediating role of ICs in the causal relationships between these factors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 11","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant- and Anxiolytic-Like Effect of the Froriepia subpinnata Extract in the Rat: Neurochemical Correlates","authors":"Mohammad R. Samandari-Bahraseman,&nbsp;Keyvan Esmaeilzadeh-Salestani,&nbsp;Manijeh Dogani,&nbsp;Banafsheh Khaleghdoust,&nbsp;Nima Hatami,&nbsp;Saeed Esmaeili-Mahani,&nbsp;Leila Elyasi,&nbsp;Evelin Loit,&nbsp;Jaanus Harro","doi":"10.1002/brb3.70171","DOIUrl":"10.1002/brb3.70171","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The study aims to explore the potential antianxiety effect of <i>Froriepia subpinnata</i>, a native plant in northern Iran, and it is considered an antiflatulent, appetizing, antiseptic, antispasmodic, and diuretic. Despite its widespread use in diets and its reputation for calming effects, no prior research has specifically investigated its antianxiety properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Rats were subjected to a variety of stressors for 24 days. Rats were treated with the <i>F. subpinnata</i> extract (100, 200, and 400 mg/kg, orally) for 14 days starting from the 10th day of stress. Then behavioral tests (elevated plus-maze, open field, sucrose preference, Morris water maze, passive avoidance) were examined. Real-time PCR was used to investigate changes in the expression of candidate genes of stress response and memory. Oxidative stress markers and corticosterone levels in serum were also measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Chronic stress reduced performance in a variety of tests of anxiety and memory, and treatment with the <i>F. subpinnata</i> extract dose-dependently improved the behavioral deficits caused by chronic stress. At the dose of 200 mg/kg, the <i>F. subpinnata</i> extract mitigated the effect of stress on the expression of several genes, such as those encoding dopamine D₁ and D₂ receptors, glutamate NMDA, and AMPA receptor subunits (Grin1 and Gria1, respectively), glucocorticoid and mineralocorticoid receptors, cholecystokinin (CCK) and CCK_B receptor, neuropeptide Y, and the GABA_A receptor alpha₂ subunit. Also, the expression of two genes, <i>TrkB</i> and <i>BDNF</i>, was significantly affected by the extract, demonstrating meaningful decreasing changes. Furthermore, treatment with the extract led to a decrease in oxidative stress and an elevation in cortisol levels in stressed animals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this study, we provide the first evidence of the antistress and antianxiety effects of <i>F. subpinnata</i> extract, along with its potential procognitive impact on memory.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"14 11","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}