Brain and Behavior最新文献

{"title":"The Default Mode Network and Visual Network Functional Connectivity Changes in Noise-Induced Hearing Loss Patients: A Resting-State fMRI Study","authors":"Wei Lian,&nbsp;Lei Zhang,&nbsp;Aijie Wang,&nbsp;Ranran Huang,&nbsp;Haijun Zhang,&nbsp;Xianghua Bao,&nbsp;GuoweiZ hang","doi":"10.1002/brb3.70465","DOIUrl":"https://doi.org/10.1002/brb3.70465","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hearing loss affects communication and hinders personal attention and cognitive ability. We hypothesized that noise-induced hearing loss (NIHL) patients during long-term noise exposure may result in multimodal plastic changes in the nonauditory central nervous system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the functional connectivity (FC) of the default mode network (DMN) and visual network (VN) in patients with occupational NIHL using resting-state functional magnetic resonance imaging (rs-fMRI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ninety-eight people with NIHL and 78 healthy controls (HCs) matched for age and educational level were enrolled. The mini–mental state examination (MMSE) was conducted, and rs-fMRI scanning was performed. The data were processed and analyzed to identify FC changes between DMN, VN, and the whole brain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the HCs, the NIHL group showed significantly enhanced connectivity with multiple brain regions when utilizing the DMN as seed regions of interest (ROI), with only some brain regions showing significantly decreased connectivity. When the VN was used as the seed ROI, the NIHL group showed significantly enhanced connectivity with multiple brain regions (corrected by GRF, <i>p </i>&lt; 0.05). In the present study, the FC between multiple brain areas of VN and DMN in the NIHL patient group was enhanced compared to the normal population. The phenomenon of “perceptual compensation” is confirmed. The results of this study suggest that NIHL causes various changes in brain function related to emotion, decision-making, social cognition, and psychopathology. It suggests that changes in brain functional networks involve complex processes involving plasticity and damage to multiple networks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The NIHL patients showed abnormal FC changes in both the DMN and VN, indicating widespread multimodal plasticity and reorganization of nonauditory central nervous system functions in people with NIHL.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compulsive Exercise and Changes in Physical Activity Among Females: A Longitudinal Analysis During the First 12 Months of the COVID-19 Pandemic","authors":"Hannah J. White,&nbsp;Chris J. McLeod,&nbsp;Emma Haycraft,&nbsp;Carolyn R. Plateau,&nbsp;Clare E. Holley,&nbsp;Gemma L. Witcomb","doi":"10.1002/brb3.70456","DOIUrl":"https://doi.org/10.1002/brb3.70456","url":null,"abstract":"<p>This study had two aims; first to explore changes in compulsive exercise among adult females across the first year of the COVID-19 pandemic, and second, to explore how changes to physical activity early in the pandemic impacted compulsive exercise.</p><p>Participants were 174 adult females who completed online surveys four times (T1–T4) during the first 12 months of the pandemic. Participants reported changes in physical activity (T1) and completed the compulsive exercise test (CET) at each time point (T1–T4).</p><p>Mixed ANOVAs with time (T1–T4) and group (did versus did not report changes in physical activity) as factors revealed that compulsive exercise significantly differed across timepoints for the whole sample. Furthermore, females who reported that their physical activity levels had changed early in the pandemic reported higher levels of CET Weight Control Exercise compared to those who reported no change. No significant interactions were found.</p><p>Among this sample of adult females, attitudes towards exercise changed during the first year of the pandemic, which may reflect the impact of varying lockdown restrictions. Additionally, changes to physical activity early in the pandemic were linked with exercising to control body weight. This suggests that externally influenced changes in physical activity may be an influential factor in the development of compulsive exercise. This may have implications for understanding and managing risk in a range of transition situations that impact upon physical activity.</p>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal Ideation in Patients With Multiple Sclerosis and Its Association With Clinical and Demographic Characteristics","authors":"Elham Bazmi,&nbsp;Amir Hossein Behnoush,&nbsp;Sharareh Eskandarieh,&nbsp;Abdorreza Naser Moghadasi,&nbsp;Samira Navardi,&nbsp;Saeideh Ayoubi,&nbsp;Behnam Behnoush,&nbsp;Mehdi Forouzesh,&nbsp;Mohammad Ali Sahraian","doi":"10.1002/brb3.70458","DOIUrl":"https://doi.org/10.1002/brb3.70458","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic neurological diseases, such as multiple sclerosis (MS) are important risk factors for some psychological disorders, such as depression and consequently suicidal behavior. As suicidal ideation (SI) is one of the important factors in predicting suicide attempts and suicide deaths, the recognition of factors related to the occurrence of SI in patients with MS has high value.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to assess the association between sociodemographic, psychological, and disease characteristics with SI in patients with MS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A sample of 400 subjects with MS was selected from a referral outpatient MS clinic in Tehran, Iran (2024). Participants completed a personal information questionnaire, the patient health questionnaire-9 (PHQ-9), the hospital anxiety and depression scale (HADS), and the beck scale for suicidal ideation (BSSI). Logistic regression models (univariate and multivariate) were conducted to determine the association between each variable and SI using odds ratio (OR) and 95% confidence interval (CI). Finally, the correlation between depression, anxiety, and the SI scale was measured by bivariate Pearson correlation analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The sample consisted of 77% women, and the mean age was 36.91 years. Among them, 149 (37.2%) of cases were identified with suicidal ideation at some period in life. Findings in the multivariate regression model represented that an increase in age had a significant protective effect on SI (adjusted OR [AOR] 0.95, 95% CI 0.92 to 0.98, <i>p</i> = 0.003). Moreover, the history of previous suicide attempts doubled the odds of SI (AOR 2.18, 95% CI 1.05 to 4.54, P = 0.038). Finally, both depression score (measured by PHQ-9) and anxiety score (measured by HADS) had significant associations with SI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>People with MS are highly prone to suicidal thoughts and even suicide attempts; this should not be ignored in routine clinical visits due to other physical complaints. They need to be discussed with patients, and effective psychiatric interventions should be applied to reduce the risks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Ischemia-Reperfusion Injury Research in Ischemic Stroke: Insights From a Two-Decade Bibliometric Analysis","authors":"Hongyu Xu,&nbsp;Xinglin Lu,&nbsp;Rongxing Qin,&nbsp;Lingduo Shao,&nbsp;Li Chen","doi":"10.1002/brb3.70445","DOIUrl":"https://doi.org/10.1002/brb3.70445","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ischemic stroke is a complex disease with high mortality and disability rates. Ischemia-reperfusion injury is a common aftermath. There have been significant advancements in understanding ischemia-reperfusion injury in ischemic stroke over the past two decades. This study aims to evaluate the current state of ischemia-reperfusion injury in ischemic stroke through bibliometric analysis, identifying key research areas and emerging trends.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Relevant documents in the Web of Science Core Collection, SCI-Expanded from January 1, 2003, to December 31, 2023, were downloaded on July 10, 2024. Bibliometric analysis was performed using HistCite, VOSviewer, CiteSpace, and Bibliometrics online analysis platform.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 2179 research papers from 611 journals in 66 countries were included in this study. Among these papers, China emerged as the leading contributor of ischemia-reperfusion injury in ischemic stroke publications, with Capital Medical University standing out as the institution with the highest number of publications in this area. Y. Zhang was identified as the author with the most publications during the study period. <i>Brain Research</i> was found to be the most prolific journal for this research. The keywords “ferroptosis”, “circular RNA”, “polarization”, and “fatty acid binding protein” represent the current hot spots of ischemia-reperfusion injury in ischemic stroke research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This bibliometric analysis offers the first thorough overview of hot spots and research trends in ischemia-reperfusion injury in ischemic stroke over the previous 21 years, providing researchers with new ideas in the field. “ferroptosis”, “circular RNA”, “polarization”, and “fatty acid binding protein” may be the focus of future studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Vestibulo-Ocular Reflex is Associated With Visuospatial Dysfunction in Patients With Parkinson's Disease","authors":"Yukang Kim,&nbsp;Tonghoon Woo,&nbsp;Seoui Kwag,&nbsp;Hyunsoh Park,&nbsp;Hanseob Kim,&nbsp;Kyoungwon Baik,&nbsp;Sun-Uk Lee,&nbsp;Euyhyun Park,&nbsp;Chan-Nyoung Lee,&nbsp;Gerard J. Kim,&nbsp;Ji-Soo Kim","doi":"10.1002/brb3.70453","DOIUrl":"https://doi.org/10.1002/brb3.70453","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Visuospatial impairment is one of the most frequent cognitive deficits in patients with Parkinson's disease (PD). It remains unknown whether the vestibulo-ocular reflex (VOR) function affects visuospatial perception and memory in patients with PD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To delineate the relationship between VOR and visuospatial function in patients with PD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We prospectively evaluated video head-impulse tests in 151 patients with PD (mean age &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mspace&gt;&lt;/mspace&gt;\u0000 &lt;mo&gt;±&lt;/mo&gt;\u0000 &lt;mspace&gt;&lt;/mspace&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$; pm ;$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; standard deviation, 68 &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mspace&gt;&lt;/mspace&gt;\u0000 &lt;mo&gt;±&lt;/mo&gt;\u0000 &lt;mspace&gt;&lt;/mspace&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$; pm ;$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; 9 years; 77 male). All patients conducted the Rey Complex Figure test (RCFT).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;RCFT-copying and RCFT-delayed recall were impaired in 11 (11/151, 7%) and 15 (15/151, 10%) patients, respectively. The VOR gain was normal in 55 patients with PD (55/151, 36%). However, 69 patients overestimated VOR gain for at least one canal, and 34 patients showed a decreased gain for at least one canal (seven patients showed an overestimated gain for some canals and decreased gain for other canals). Multivariable logistic regression analysis showed that abnormal RCFT-copying was negatively associated with the VOR gain for the horizontal canal (odds ratio [OR]: 0.001, 95% confidence interval [CI]: 0.001–0.08, &lt;i&gt;p&lt;/i&gt; = 0.007). In contrast, abnormal RCFT-delayed recall was negatively associated with Mini-Mental State Examination scores (0.70, 0.52–0.93, &lt;i&gt;p&lt;/i&gt; = 0.013), positively with age (1.11, 1.00–1.22, &lt;i&gt;p&lt;/i&gt; = 0.041), male sex (12.82, 1.17–142.86, &lt;i&gt;p&lt;/i&gt; = 0.036), years of schooling (1.41, 1.09–1.82, &lt;i&gt;p&lt;/i&gt; = 0.009), but not with the VOR gain for any canal.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The VOR function may be associated with deficits in visuospatia","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Brain Age Among Psychiatrically Healthy Adults Exposed to Childhood Trauma","authors":"Chanellé Hendrikse,&nbsp;Leigh Luella van den Heuvel,&nbsp;Robin Emsley,&nbsp;Soraya Seedat,&nbsp;Stefan du Plessis","doi":"10.1002/brb3.70450","DOIUrl":"https://doi.org/10.1002/brb3.70450","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Adults with childhood trauma exposure may exhibit brain changes typically associated with aging and neurodegeneration (e.g., reduced tissue volume or integrity) to a greater degree than their unexposed counterparts, suggesting accelerated brain aging. Machine learning methods that predict a person's age based on their magnetic resonance imaging (MRI) brain scan may be useful for investigating aberrant brain aging following childhood trauma exposure. Emerging evidence indicates altered brain aging in adolescents with childhood trauma exposure; however, this association has not been examined in healthy adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We investigated the associations between childhood trauma exposure, including abuse and neglect, and brain-predicted age in psychiatrically healthy adults. “Brain age” predictions were generated from T1-weighted structural MRI scans using a pre-trained machine learning pipeline, namely brainageR. The differences between brain-predicted age and chronological age were calculated and associations with childhood trauma questionnaire scores were investigated using linear regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The final sample (<i>n</i> = 153; mean age 46 ± 16 years, 70% female) included 69 adults with childhood trauma exposure and 84 unexposed adults. Childhood sexual abuse was associated with an average increased brain age of 3.2 years, adjusting for chronological age and age-squared, sex, and scanner site; however, this finding did not survive correction for multiple comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>To our knowledge, this study represents the first published investigation of brain age in adults with childhood trauma using a machine-learning-based prediction model. Our findings suggest a link between childhood trauma exposure, specifically sexual abuse, and accelerated brain aging in adulthood, but this association should be replicated in future work. Accentuated brain aging in adulthood may increase the risk of age-related cognitive and neurodegenerative decline and associated disorders later in life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and Genomic Literacy of Healthcare Providers Treating Anorexia Nervosa in the United States: A Mixed Methods, Cross-Sectional Study","authors":"Sarah Ramsay,&nbsp;Kendra Allison,&nbsp;Heide S. Temples,&nbsp;William C. Bridges Jr.,&nbsp;Sara Sarasua","doi":"10.1002/brb3.70441","DOIUrl":"https://doi.org/10.1002/brb3.70441","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Genetic testing has the potential to transform the prevention, treatment, and management of anorexia nervosa (AN) as it has for other conditions. However, healthcare providers require the knowledge and openness to implement genetic testing effectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study had two main objectives, first, to determine the genomic literacy of those treating AN in the United States and second to assess the viewpoints of these healthcare providers on genetic testing and research, and the influence of genetics on AN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A mixed methods approach combining the GKnowM, a validated genomic literacy tool, Likert-like statements and thematic analysis of free-text responses was used. Participant consent, dissemination of the survey, and response collection were performed through Qualtrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participant's average GKnowM score was 19.6 (SD = 2.8) on a scale of 0–26 (75% correct). Positive correlations were identified between GKnowM score and responses to questions about the influence of genetics on AN and the importance of genetics research, and negative correlations were found between age and years in practice and views on the current value of genetic testing. In addition, participants communicated a need for more genetics learning opportunities, and the challenge of accessing and paying for quality AN treatment in the United States.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>The results of this study indicate a need for targeted genetics and genomics learning opportunities for healthcare providers. Improving genomic literacy has the potential to positively influence attitudes toward genetic research and testing and empower healthcare providers to engage in productive and scientifically sound discussions with their patients and society as a whole.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Italian Survey on the Management of Pediatric Convulsive Status Epilepticus: More Than Just a Pharmacological Choice","authors":"Caterina Zanus,&nbsp;Giulia Cannizzaro,&nbsp;Giacomo Danieli,&nbsp;Angela Amigoni,&nbsp;Silvia Buratti,&nbsp;Francesca Izzo,&nbsp;Massimo Mastrangelo,&nbsp;Maria Cristina Mondardini,&nbsp;Paola Costa,&nbsp;Anna Rosati,&nbsp;Carla Marini,&nbsp;Lucia Fusco,&nbsp;Italian Paediatric Status Epilepticus Group","doi":"10.1002/brb3.70433","DOIUrl":"https://doi.org/10.1002/brb3.70433","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>To explore specialists’ opinions on the current management of pediatric convulsive status epilepticus (CSE) in Italy and the main factors influencing the applicability of guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a national survey of child neurologists, pediatric emergency physicians, and intensivists. Within the multidisciplinary Italian Paediatric Status Epilepticus (IPSE) Group, a web-based 48-multiple-choice questionnaire was developed to explore treatment choices, use of internal protocols and guidelines, and self-perceived competencies in the treatment of CSE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Responses were received from 250 clinicians from 34 Italian hospitals (response rate 71%). Intravenous midazolam (iv-MDZ) was the preferred benzodiazepine (BDZ) when iv access was available (90%). When iv-access was unavailable, 75% of clinicians used BDZs; rectal diazepam was the most indicated (65.6%). Concerning second-line treatment, the choices were equally distributed between phenytoin (55.2%), levetiracetam (52.4%), and phenobarbital (52.4%). MDZ infusion at a dosage &lt; 0.23 mg/kg/h was also a frequent choice (38%). A PICU in the hospital influenced this latter choice, resulting in a significantly greater use of iv-MDZ by pediatric emergency physicians working in these hospitals. Answers’ variability was related to organizational aspects such as the availability of on-duty specialists and diagnostic tools in emergency settings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This survey confirmed that first-line treatment of pediatric CSE relied on iv-MDZ and that the heterogeneity of therapeutic choices started from the second-line treatment in real life. The survey also highlighted the need to consider the organizational heterogeneity among settings and to involve different specialties in an integrated and feasible approach.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domain-Specific and Domain-General Functional Brain Alterations in Type 2 Diabetes Mellitus: A Task-Based and Functional Connectivity Meta-Analysis","authors":"Valentino Marcel Tahamata,&nbsp;Yang-Teng Fan,&nbsp;Li Wei,&nbsp;Yen-Nung Lin,&nbsp;Roger Marcelo Martinez,&nbsp;Kah Kheng Goh,&nbsp;Yu-Chun Chen,&nbsp;Chenyi Chen","doi":"10.1002/brb3.70438","DOIUrl":"https://doi.org/10.1002/brb3.70438","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Patients with Type 2 diabetes experience cognitive and affective deficits linked to widespread functional brain alterations. However, previous meta-analyses of functional neuroimaging have primarily focused on the resting-state studies. While valuable, this approach may have overlooked the key neuronal mechanisms underlying these deficits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To address this, we conducted a coordinate-level task-based meta-analysis of functional neuroimaging via a systematic search of Embase, PubMed, Medline, and Web of Science (December 2023), alongside task-based and task-free connectivity analyses using the BrainMap database. Activation likelihood estimations were applied to two task categories: that are, cognitive and affective. To control for biased results, we also conducted jackknife sensitivity analysis and within-paper combined experiments analysis as validation analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified a cluster of activation in cognitive paradigm (18 contrasts, 153 foci, 767 subjects), with the middle frontal gyrus, part of the medial frontal cortex, as the peak region. For the affective paradigm (18 contrasts, 181 foci, 951 subjects), we observed both increased and decreased activities. Two increased clusters peak in the amygdala and middle temporal gyrus, while the three decreased clusters were inferior frontal gyrus, insula, and putamen. Follow-up connectivity analyses showed that these brain alterations were both task-specific and task-generic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite the lack of uniformity across task, such domain-specific and domain-general patterns of alterations provide a more nuanced understanding of the cognitive and affective deficits in Type 2 diabetes patients. This highlights the varied neuronal mechanisms underlying these deficits.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review","authors":"Alexandre Carpentier,&nbsp;Dimitrios Zampetas,&nbsp;Alexandre Durand,&nbsp;Mickael Naassila,&nbsp;Marie-Cécile Bralet","doi":"10.1002/brb3.70384","DOIUrl":"https://doi.org/10.1002/brb3.70384","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Patients with schizophrenia spectrum disorders (SSD), particularly patients with schizophrenia, have social cognitive impairments characterized by difficulties in emotion recognition, the ability to attribute mental states, explaining the causes of events, and identifying and utilizing social cues. These impairments appear from early life and are associated with poor functional and social prognosis. The origin of these impairments is not fully understood. The inflammatory hypothesis is one of the pathophysiological hypotheses of schizophrenia. Inflammatory marker abnormalities are also present in the early stages of schizophrenia and are associated with neuronal degeneration. Following our main hypothesis, the aim of this work was to conduct a review to explore the relationship between social cognition and inflammatory markers in SSD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The review included original studies reporting measures of social cognition and plasma levels of inflammatory markers in patients with SSD using the Pubmed, PsycINFO, and Embase databases. The PRISMA methodology was followed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eleven studies were selected and analyzed. They showed significant correlations between plasma cytokine levels and theory of mind and facial emotion recognition abilities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The correlations do not seem to be specific to social cognitive impairments, but our results support the hypothesis of a link between pro- and anti-inflammatory markers and cognition in SSD. In the future, other studies should be conducted to clarify this link from a diagnostic and therapeutic perspective: identification of inflammatory trait factors and patient subgroups and personalized anti-inflammatory therapies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":9081,"journal":{"name":"Brain and Behavior","volume":"15 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/brb3.70384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}