Nature Human Behaviour最新文献

Reproductive and cognitive phenotypes in carriers of recessive pathogenic variants 隐性致病变异携带者的生殖和认知表型

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-15 DOI: 10.1038/s41562-025-02204-7

Hila Fridman, Gelana Khazeeva, Ephrat Levy-Lahad, Christian Gilissen, Han G. Brunner

{"title":"Reproductive and cognitive phenotypes in carriers of recessive pathogenic variants","authors":"Hila Fridman, Gelana Khazeeva, Ephrat Levy-Lahad, Christian Gilissen, Han G. Brunner","doi":"10.1038/s41562-025-02204-7","DOIUrl":"https://doi.org/10.1038/s41562-025-02204-7","url":null,"abstract":"The genetic landscape of human Mendelian diseases is shaped by mutation and selection. Although selection on heterozygotes is well-established in autosomal-dominant disorders, convincing evidence for selection in carriers of pathogenic variants associated with recessive conditions is limited. Here, we studied heterozygous pathogenic variants in 1,929 genes, which cause recessive diseases when bi-allelic, in n = 378,751 unrelated European individuals from the UK Biobank. We find evidence suggesting fitness effects in heterozygous carriers for recessive genes, especially for variants in constrained genes across a broad range of diseases. Our data suggest reproductive effects at the population level, and hence natural selection, for autosomal-recessive disease variants. Further, variants in genes that underlie intellectual disability are associated with lower educational attainment in carriers, and we observe an altered genetic landscape, characterized by a threefold reduction in the calculated frequency of bi-allelic intellectual disability in the population relative to other recessive disorders.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"29 1","pages":""},"PeriodicalIF":29.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social media interventions to improve well-being 社交媒体干预提高幸福感

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-15 DOI: 10.1038/s41562-025-02167-9

Amira Skeggs, Amy Orben

引用次数: 0

ChatGPT decreases idea diversity in brainstorming ChatGPT减少了头脑风暴中的想法多样性

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-14 DOI: 10.1038/s41562-025-02173-x

Lennart Meincke, Gideon Nave, Christian Terwiesch

{"title":"ChatGPT decreases idea diversity in brainstorming","authors":"Lennart Meincke, Gideon Nave, Christian Terwiesch","doi":"10.1038/s41562-025-02173-x","DOIUrl":"https://doi.org/10.1038/s41562-025-02173-x","url":null,"abstract":"arising from B. C. Lee & J. J. Chung Nature Human Behaviour https://doi.org/10.1038/s41562-024-01953-1 (2024)Lee and Chung1 explore how ChatGPT augments human creativity in brainstorming. In a series of experiments, they randomized participants to complete various creative challenges, either with or without the help of ChatGPT. These challenges included tasks such as coming up with gift ideas, designing toys from everyday objects and repurposing household items. Each participant submitted one idea, which external evaluators rated on multiple creativity dimensions, including innovativeness and usefulness. Across tasks, instructing participants to use ChatGPT enhanced the average creativity of ideas, outperforming web searches and unaided human intuition, with creativity measured as the average of aggregated scores of originality (original, innovative, creative) and appropriateness (practical, effective, useful). These results strengthen the empirical evidence for the effectiveness of large language models in idea generation, contributing to a rapidly growing literature2,3,4. However, as we demonstrate analytically, reliance on ChatGPT for idea generation comes with a trade-off: while enhancing individual ideas’ creativity, it reduces the diversity of ideas in a pool of ideas—a critical element for effective brainstorming.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"4 1","pages":""},"PeriodicalIF":29.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Information transfer within and between autistic and non-autistic people 自闭症患者和非自闭症患者之间的信息传递

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-14 DOI: 10.1038/s41562-025-02163-z

Catherine J. Crompton, Sarah J. Foster, Charlotte E. H. Wilks, Michelle Dodd, Themis N. Efthimiou, Danielle Ropar, Noah J. Sasson, Martin Lages, Sue Fletcher-Watson

{"title":"Information transfer within and between autistic and non-autistic people","authors":"Catherine J. Crompton, Sarah J. Foster, Charlotte E. H. Wilks, Michelle Dodd, Themis N. Efthimiou, Danielle Ropar, Noah J. Sasson, Martin Lages, Sue Fletcher-Watson","doi":"10.1038/s41562-025-02163-z","DOIUrl":"https://doi.org/10.1038/s41562-025-02163-z","url":null,"abstract":"Autism is clinically defined by social communication deficits, suggesting that autistic people may be less effective at sharing information, particularly with one another. However, recent research indicates that neurotype mismatches, rather than autism itself, degrade information sharing. Here, using the diffusion chain method, we examined information transfer in autistic, non-autistic and mixed-neurotype chains (N = 311), replicating and extending a key study. We hypothesized that information transfer would deteriorate faster and rapport would be lower in mixed-neurotype compared with single-neurotype chains. Additionally, we examined whether informing participants of the diagnostic status of their chain and whether information was fictional or factual impacted performance and rapport. We found no difference in information transfer between single-neurotype and mixed-neurotype chains. Non-autistic chains indicated higher rapport, and disclosing diagnosis improved rapport. This result challenges assumptions about autistic communication deficits but contrasts with prior findings. Enhanced participant heterogeneity and methodological differences may explain these unexpected results. Protocol registration The Stage 1 protocol for this Registered Report was accepted in principle on 23 August 2022. The protocol, as accepted by the journal, can be found at https://osf.io/us9c7/.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"10 1","pages":""},"PeriodicalIF":29.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to: ChatGPT decreases idea diversity in brainstorming ChatGPT在头脑风暴中减少了想法的多样性

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-14 DOI: 10.1038/s41562-025-02195-5

Byung Cheol Lee, Jaeyeon ‘Jae’ Chung

引用次数: 0

What I wish I knew when I switched fields for my PhD 这是我当初换专业读博时希望知道的

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-13 DOI: 10.1038/s41562-025-02214-5

Sterling Williams-Ceci

引用次数: 0

Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice 将疾病多基因风险评分纳入临床实践的心理和行为考虑

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-12 DOI: 10.1038/s41562-025-02200-x

Saskia C. Sanderson, Michael Inouye

引用次数: 0

Evidence of organized but not disorganized attachment in wild Western chimpanzee offspring (Pan troglodytes verus) 野生西方黑猩猩后代有组织而非无组织依恋的证据（泛类人猿）

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-12 DOI: 10.1038/s41562-025-02176-8

Eléonore Rolland, Oscar Nodé-Langlois, Patrick J. Tkaczynski, Cédric Girard-Buttoz, Holly Rayson, Catherine Crockford, Roman M. Wittig

引用次数: 0

Biological markers and psychosocial factors predict chronic pain conditions 生物标记和社会心理因素预测慢性疼痛状况

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-12 DOI: 10.1038/s41562-025-02156-y

Matt Fillingim, Christophe Tanguay-Sabourin, Marc Parisien, Azin Zare, Gianluca V. Guglietti, Jax Norman, Bogdan Petre, Andrey Bortsov, Mark Ware, Jordi Perez, Mathieu Roy, Luda Diatchenko, Etienne Vachon-Presseau

{"title":"Biological markers and psychosocial factors predict chronic pain conditions","authors":"Matt Fillingim, Christophe Tanguay-Sabourin, Marc Parisien, Azin Zare, Gianluca V. Guglietti, Jax Norman, Bogdan Petre, Andrey Bortsov, Mark Ware, Jordi Perez, Mathieu Roy, Luda Diatchenko, Etienne Vachon-Presseau","doi":"10.1038/s41562-025-02156-y","DOIUrl":"https://doi.org/10.1038/s41562-025-02156-y","url":null,"abstract":"Chronic pain is a multifactorial condition presenting significant diagnostic and prognostic challenges. Biomarkers for the classification and the prediction of chronic pain are therefore critically needed. Here, in this multidataset study of over 523,000 participants, we applied machine learning to multidimensional biological data from the UK Biobank to identify biomarkers for 35 medical conditions associated with pain (for example, rheumatoid arthritis and gout) or self-reported chronic pain (for example, back pain and knee pain). Biomarkers derived from blood immunoassays, brain and bone imaging, and genetics were effective in predicting medical conditions associated with chronic pain (area under the curve (AUC) 0.62–0.87) but not self-reported pain (AUC 0.50–0.62). Notably, all biomarkers worked in synergy with psychosocial factors, accurately predicting both medical conditions (AUC 0.69–0.91) and self-reported pain (AUC 0.71–0.92). These findings underscore the necessity of adopting a holistic approach in the development of biomarkers to enhance their clinical utility.","PeriodicalId":19074,"journal":{"name":"Nature Human Behaviour","volume":"21 1","pages":""},"PeriodicalIF":29.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infant attachment in chimpanzees 黑猩猩的婴儿依恋

IF 29.9 1区心理学

Nature Human Behaviour Pub Date : 2025-05-12 DOI: 10.1038/s41562-025-02177-7

Anna Truzzi

引用次数: 0