Behavioural Brain Research最新文献

{"title":"HMGB1/RAGE signaling mediates the activation of microglia and participates in depressive-like behaviors and cognitive deficits in rats after ischemia-reperfusion","authors":"Lifei Fan ,&nbsp;Xinyue Zhang ,&nbsp;Xiaojia Song ,&nbsp;Lina Yang ,&nbsp;Huanhuan Liu ,&nbsp;Yunfei Zhang ,&nbsp;Kun Li ,&nbsp;Xuejiao Jin ,&nbsp;Hao Lei ,&nbsp;Zhaohui Zhang ,&nbsp;Fuping Zhang ,&nbsp;Jinggui Song","doi":"10.1016/j.bbr.2025.115662","DOIUrl":"10.1016/j.bbr.2025.115662","url":null,"abstract":"<div><div>Post-stroke depression (PSD) is a common psychiatric complication that occurs after stroke, especially in ischemic stroke (I/S). It has been reported that high-mobility group box-1 (HMGB1) is highly expressed in clinical PSD patients, but the exact molecular mechanism of its involvement in PSD is not completely clear, the neuroinflammation may participate in its development. Thus, we established a PSD rat model, observed behavioral and cognitive deficits, and found that the HMGB1/ receptor for advanced glycation end products (RAGE) pathway were activated in microglia. Glycyrrhizin acid (GA), an inhibitor of HMGB1, inhibited microglial activation, reversed the expression of HMGB1/RAGE, and ameliorated depressive-like behaviors in PSD rats. GA also reduced the expression of MAPK and NF-κB, which further led to decreased expression of IL-1β and NLRP3 inflammasome. These results suggested that the HMGB1/RAGE pathway was involved in microglial activation in the PSD model, promoting neuroinflammation and depressive-like behaviors.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"492 ","pages":"Article 115662"},"PeriodicalIF":2.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emulation as a behavioral strategy underlying spatial observational learning in rats","authors":"Yerko Fuentealba ,&nbsp;José Tomás García-Molina ,&nbsp;Maximiliano Downey ,&nbsp;José L. Valdés","doi":"10.1016/j.bbr.2025.115645","DOIUrl":"10.1016/j.bbr.2025.115645","url":null,"abstract":"<div><div>Humans and several non-human species have shown the ability to learn by observing an experimented conspecific. A basic form of this learning is spatial observational learning (sOL), where a naïve animal improves their accuracy in a spatial task after witnessing a demonstrator solve the same task. This ability has gained neurophysiological support with the discovery of hippocampal CA1 social place cells, which encoded the position of others, and the role of CA2 and ventral CA1 neurons in processing and storing social memory. However, the direct role of the hippocampus in accomplishing sOL and the behavioral changes adopted by the observer animal have not been fully understood. Observational learning can be explained by behavioral processes such as imitation, emulation, or local enhancement. We used a modified version of the oasis maze to unravel the strategy unfolded by naïve observer rats during sOL. Our results suggest that emulation is the primary strategy implemented by observers by switching from a free-foraging approach to goal-directed behavior. Furthermore, the pharmacological inactivation of the hippocampus during the observation period impeded sOL, revealing the necessity of this structure for engaging in this behavioral change. Our results propose that the hippocampus is necessary for the internal representation of the demonstrator in the space and their movement towards a particular area and for the animal comprehension of the behavioral purpose of others during observational learning.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"491 ","pages":"Article 115645"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel object recognition task for mice: Is it a test for memory, object neophobia or innate preference?","authors":"H. Koivisto,&nbsp;C. Maguire,&nbsp;H. Tanila","doi":"10.1016/j.bbr.2025.115649","DOIUrl":"10.1016/j.bbr.2025.115649","url":null,"abstract":"<div><div>Novel object recognition task (NOR) is one of the most widely used memory tests for mice. Over the years of intensive use, the test protocol has become largely standardized except for one detail, the objects themselves. In three experiments including in total 41 C57BL/6 J mice, we tested the impact of the object novelty vs. its general appeal to an individual mouse using 18 object pairs. This was possible by having a cross-over design where the same object was familiar to half of the mice and novel for the other half. Some objects were consistently approached or avoided across mice. However, an object pair that showed a strong novelty preference in one group of mice, could fail to do so in another group. Therefore, a counterbalance design of the object assignments is important. Pre-test habituation of mice to the presence of objects in their home cage increased object exploration in the test for the first three object pairs. We also assessed how well the object-related details in NOR are disclosed in current literature. As a representative sample, we searched for NOR reporting in mice published in top-tier Nature journals during 2024 and found 69 articles. Notably, only 24.6 % of the articles described the objects and only 14.5 % employed a cross-over design. Most alarming was that 20.3 % of the reports mixed up object neophobia and memory as the task outcome. Obviously, more detailed reporting is needed to ensure reproducibility of results obtained with the NOR test in mice.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"491 ","pages":"Article 115649"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease.","authors":"Lili Li, Shiyin Li, Lei Cai, Xiaofeng Yang, Yifeng Feng, Liying Zhang, Xiaofei He, Mingyue Li","doi":"10.1016/j.bbr.2025.115650","DOIUrl":"https://doi.org/10.1016/j.bbr.2025.115650","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the primary cause of dementia in older individuals, exhibiting an increasing incidence worldwide. Endoplasmic reticulum (ER) quality control has been receiving attention in the pathology of AD. The accumulation of misfolded proteins in the ER will activates the unfolded protein response (UPR), leading to cellular apoptosis. Using a mouse model of 5xFAD, we found that physical exercise (PE) promoted the clearance of ER fragments and inhibited the ER stress via ER autophagy (ER - Phagy). As a result, physical exercise reduced Aβ deposition, inhibited the neuronal apoptosis, ameliorated the emotional and cognitive impairments. Mechanistically, these PE related effects may be linked to the increased FAM134B, an ER-Phagy receptor, by up-regulating neuronal progranulin (Pgrn). Recombinant Pgrn injection could mimic the protective effects of PE, whereas down-regulation of Pgrn could abolish the PE-associated protection. Our findings indicate that physical exercise, as a readily accessible lifestyle intervention, holds significant potential for preventing diseases related to the global aging population.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115650"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grey matter loss across deteriorating cognitive stages in Parkinson’s disease","authors":"M. Chondrogiorgi ,&nbsp;L. Astrakas ,&nbsp;A. Zikou ,&nbsp;M.I. Argyropoulou ,&nbsp;S. Konitsiotis","doi":"10.1016/j.bbr.2025.115654","DOIUrl":"10.1016/j.bbr.2025.115654","url":null,"abstract":"<div><div>The purpose of the present study was to depict the pattern of grey matter (GM) abnormalities in patients with Parkinson’s disease (PD) and various stages of cognitive decline. GM changes were investigated with the use of voxel-based morphometry in three age-matched groups consisted of PD patients with normal cognition (PD-NC, n = 20), mild cognitive impairment (PD-MCI, n = 20) and dementia (PDD, n = 21). The Parkinson’s disease-cognitive rating scale (PD-CRS) was used for the neuropsychological assessment of the subjects and to define patient groups. GM atrophy was observed in the PD-MCI group in right middle and inferior temporal gyri and in the PDD group in right thalamus and hippocampus both compared to PD-NC group. Regression analyses retrieved significant associations among total, cortical, and subcortical PD-CRS scores and GM volume in multiple areas, with an exceptionally stable finding being the correlation of striatal atrophy with deteriorating cognitive function. Significant associations were also observed between GM volume in specific regions and the performance of patients in particular PD-CRS items. The study findings reveal a central role of striatal atrophy in the PD-related cognitive decline. Degenerative changes in temporal regions could contribute to MCI, while hippocampal and thalamic atrophy are proposed to accompany the transition to dementia.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"491 ","pages":"Article 115654"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutraceutical approaches for Autism Spectrum Disorder treatment","authors":"Fernando Dobrachinski ,&nbsp;Kátia Alves Ribeiro ,&nbsp;Iverson Conrado Bezerra ,&nbsp;Artur José da Silva ,&nbsp;Camila Milagres Macedo Pereira ,&nbsp;Kelle Vellasques ,&nbsp;Heloísa Aiolfi Padilha ,&nbsp;Sandra Elisa Haas ,&nbsp;Daiana Silva Ávila ,&nbsp;Priscila Gubert","doi":"10.1016/j.bbr.2025.115653","DOIUrl":"10.1016/j.bbr.2025.115653","url":null,"abstract":"<div><div>The Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that has been increasing in prevalence and is characterized by some degree of difficulty with social interaction, communication, and sensory response. According to the World Health Organization, ASD affects 1 in 100 children, and many factors may cause brain alterations, such as genetic and environmental factors. Currently, there is no standard treatment for ASD. Notably, one of the hallmarks of this condition is neuroinflammation since it has been suggested that autism results from central nervous system derangements due to chronic inflammatory reactions, with activation of microglial cells. Therefore, antioxidant and anti-inflammatory compounds may be nutraceutical supplements of interest to attenuate the impacts of neuroinflammation in ASD subjects. This review highlights the main molecules that have been successful in preclinical and clinical trials, as well as potential associations that might be further strategies to investigate.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"492 ","pages":"Article 115653"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Episodic memory and reproductive condition could independently influence the pair bond maintenance in the male prairie vole (Microtus ochrogaster): Ecological implications and translational relevance in the study of sub-clinical manifestations of schizophrenia","authors":"Enrique Basurto ,&nbsp;Alexander G. Ophir ,&nbsp;Bibiana Montoya ,&nbsp;Hugo Cano-Ramírez ,&nbsp;Oscar González-Flores ,&nbsp;Monserrat Suárez-Rodríguez ,&nbsp;Kurt Hoffman","doi":"10.1016/j.bbr.2025.115648","DOIUrl":"10.1016/j.bbr.2025.115648","url":null,"abstract":"<div><div>Investigations on mating tactics of the prairie vole (<em>Microtus ochrogaster</em>, a socially monogamous rodent) have suggested that reproductive pair bonding and monogamy in this species are associated with increased capacity for social-spatial memory. In the present study, we tested this possibility in male voles that had been co-housed for an extended period with a female, by applying a behavioral test designed to assess familiarity recollection (FR) and novelty detection (ND) components of social, object, social-spatial, and object-spatial memory. We also assessed each male vole’s preference to display affiliative behavior toward his mate, relative to an unfamiliar female, as well as the reproductive success of the pair. We found that ND of social-spatial stimuli and reproductive success were independent positive predictors of the male’s affiliative preference for his partner female. ND of social, object, and object-spatial stimuli were not associated with male affiliative preference, nor were FR responses to any of these stimuli. Reproductive success was associated with both object-spatial and social-spatial ND. Taken together, the present results indicate that pair bond maintenance in the prairie vole is importantly associated with increased detection of and/or attention to alterations in associations between individual conspecifics and their spatial location. Independently, reproductive success appears to favor detection of object-spatial and social-spatial novelty. These results are discussed in relation to vole natural history, as well as in the context of their possible significance for elucidating relationships between episodic memory deficits and dysfunctional social behavior in pathological conditions such as schizophrenia.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"492 ","pages":"Article 115648"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIM2 mediated neuron PANoptosis plays an important role in diabetes cognitive dysfunction","authors":"Chengning Ma,&nbsp;Xiang Zhou,&nbsp;Siyang Pan,&nbsp;Lumei Liu","doi":"10.1016/j.bbr.2025.115651","DOIUrl":"10.1016/j.bbr.2025.115651","url":null,"abstract":"<div><div>The increasing global aging population has led to a rise in diabetic cognitive dysfunction (DCD), a common complication of diabetes that significantly impacts the health of elderly individuals. Neuronal death is a key factor in cognitive impairment, with studies showing interactions between cellular pyroptosis, apoptosis, and necroptosis in the development of neurodegenerative disorders. This has led to the concept of PANoptosis, where these pathways work together to cause cell death. High glucose levels can induce neuronal damage and cognitive dysfunction in rats, leading to various forms of programmed cell death. It is hypothesized that high glucose can trigger neuronal PANoptosis, resulting in cognitive dysfunction. AIM2, an upstream regulator of PANoptosis, is closely associated with the pathogenesis of DCD. In DCD, dysregulated glucose metabolism induces the release of mitochondrial DNA (mtDNA), which acts as a ligand to activate the cell membrane-bound DNA sensor AIM2. Upon activation, AIM2 oligomerizes and recruits a caspase recruit domain (ASC), forming a complex that activates caspase-1. Caspase-1 activation subsequently triggers the production of pro-inflammatory cytokines, induces pyroptosis, and mediates apoptosis, necroptosis, and PANoptosis in neurons through signaling crosstalk. Understanding the pathophysiological mechanism of AIM2-mediated neuronal PANoptosis in DCD development can aid in early diagnosis and identify new therapeutic targets.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"491 ","pages":"Article 115651"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neural underpinnings of body image-related cyberbullying in adolescent females: A proposed neurobiological model","authors":"Taliah Prince ,&nbsp;Christina Driver ,&nbsp;Amanda Boyes ,&nbsp;Kate E. Mulgrew ,&nbsp;Rosiel Elwyn ,&nbsp;Lia Mills ,&nbsp;Daniel F. Hermens","doi":"10.1016/j.bbr.2025.115647","DOIUrl":"10.1016/j.bbr.2025.115647","url":null,"abstract":"<div><h3>Background</h3><div>The widespread adoption of social media has precipitated an increase in cyberbullying. Body image-related cyberbullying (BRC)- which targets an individuals body shape, weight or size -is particularly prevalent among adolescent females, and is associated with negative body image outcomes and eating disorder symptoms. Although research has begun to address the prevalence and psychological impacts of BRC, a significant gap remains in our understanding of the specific neurobiological responses of adolescent females to BRC. This paper presents the body image-related cyberbullying neurobiological model (BRC-NM), which can be used as a framework to investigate the neural underpinnings of adolescent females’ responses to BRC.</div></div><div><h3>Method</h3><div>Drawing from functional magnetic resonance imaging (fMRI) studies of body image and peer victimisation, the BRC-NM details the complex interactions among neural, psychological, and social factors likely involved in experiences of BRC.</div></div><div><h3>Results</h3><div>The BRC-NM delineated several key brain regions involved in emotional regulation, self-referential thought, and social cognition that are proposed to be involved in the emotional and cognitive processing of viewing BRC.</div></div><div><h3>Conclusion</h3><div>By integrating existing knowledge and establishing connections across disciplines such as psychology and neurobiology, the BRC-NM contributes to the evolving field of neurobiological research, enhancing our understanding of the impact of BRC and supporting the development of targeted interventions.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"492 ","pages":"Article 115647"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased tyrosine hydroxylase abundance in the ventral tegmental area after taste-immune associative learning with saccharin or sucrose in rats","authors":"Jasmin Schmidt ,&nbsp;Laura Lückemann ,&nbsp;Manfred Schedlowski ,&nbsp;Martin Hadamitzky ,&nbsp;Marie Jakobs","doi":"10.1016/j.bbr.2025.115646","DOIUrl":"10.1016/j.bbr.2025.115646","url":null,"abstract":"<div><div>Several animal studies have already demonstrated classical conditioning of immune responses, when a novel sweet solution was paired with the administration of an immunosuppressive drug. However, since sweet solutions are known to have an impact on central dopamine synthesis, their “neutrality” as conditioned stimuli has been questioned. In particular, it is not clear whether even re-exposure to water is sufficient to influence central dopamine synthesis when animals are on a specific fluid-restricted conditioning schedule and whether re-exposure to saccharin or sucrose has similar or different effects. To address this, we conducted a taste-immune associative learning study in rats, using saccharin or sucrose and the immunosuppressive drug fingolimod. Subsequently, we analyzed central tyrosine hydroxylase (TH) abundance and phosphorylation (pTH) to indirectly assess dopamine production. Moreover, we measured central monoamine oxidase A (MAO-A) abundance, thereby gaining information of possible immediate conversion of synthesized dopamine. Western blot analyses of the ventral tegmental area revealed no differences in pTH abundance among fluid-restricted rats that received either water, sucrose, saccharin or fingolimod. However, TH abundance was significantly increased in animals re-exposed to sucrose and saccharin compared to those given water. MAO-A abundance did not differ between groups. Analyses of the abundance and phosphorylation of dopamine-associated enzymes in the ventral and dorsal striatum, showed no differences between groups. These exploratory findings suggest that the consumption of sucrose and saccharin may be more rewarding than water consumption, when rats are maintained on a specific fluid-restricted conditioning schedule. However, further research is necessary to draw precise conclusions.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"491 ","pages":"Article 115646"},"PeriodicalIF":2.6,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}