Behavioural Brain Research最新文献

{"title":"Should I \"stay\" or should I \"go\"? Influence of an anticipated stop on cortical correlates of overground walking.","authors":"Daghan Piskin, Saskia Kurtzhals, Jochen Baumeister","doi":"10.1016/j.bbr.2026.116540","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116540","url":null,"abstract":"<p><p>Real-world walking frequently requires pedestrians to maintain proactive inhibition to safely navigate unpredictable environments. While cortical modulations occurring during locomotion under environmental uncertainty are well-established, the specific proactive mechanisms underlying this state of inhibitory anticipation remain unexplored. This study aimed to investigate the behavioral and cortical shifts associated with anticipating a stop during overground walking. Fourteen healthy young adults performed fluent and cautious walking tasks with an expected stop. Cortical activity and trunk acceleration were recorded using a 32-channel mobile electroencephalography and an integrated accelerometer. Step-1 latency and step-interval variability were calculated via heel strike detection. Gait-phase-related power modulations were computed, and spectral principal component analysis was applied to attenuate artifacts. The results revealed that cautious walking significantly increased step-interval variability, whereas step-1 latency remained unaffected. At the cortical level, left frontotemporal areas exhibited an attenuated and delayed theta desynchronization during the swing phase. Furthermore, centroparietal regions demonstrated an altered temporal profile of alpha and beta synchronization, characterized by enhanced late-stance synchronization and reduced swing-phase synchronization. The present findings suggest that anticipating a potential stop may alter the rhythmic consistency of gait and reorganize phase-specific cortical dynamics. Being prepared to stop may shift the neural control of automated locomotion toward active monitoring, highlighting the relevance of proactive inhibition during everyday mobility.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116540"},"PeriodicalIF":2.9,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal piromelatine treatment is associated with attenuated behavioral alterations and sex-specific changes in hippocampal pCREB/BDNF signaling in adult offspring following prenatal constant-light exposure.","authors":"Tsveta Stoyanova, Petya Ivanova, Jana Tchekalarova","doi":"10.1016/j.bbr.2026.116539","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116539","url":null,"abstract":"<p><p>Maternal exposure to constant light during pregnancy (CLE) is associated with disrupted circadian organization and persistent behavioral alterations in adult offspring. This study examined behavioural performance and 24-hour locomotor activity patterns, as well as hippocampal pCREB and BDNF levels, in adult male and female offspring following prenatal CLE and maternal treatment with piromelatine (pir), which acts as an agonist at melatonin MT1/MT2 and serotonin 5-HT1A/5-HT1D receptors. Pregnant Wistar rats under light-dark regime received vehicle (veh), whereas dams exposed to CLE received vehicle (LL-veh), pir (10mg/kg), or melatonin. Compared to the LL-veh groups, offspring from pir-treated dams exhibited reduced anxiety- and depression-like responses and improved working memory in both sexes. Individual-subject cosinor analysis revealed heterogeneous 24-hour locomotor rhythmicity within and between groups. No significant treatment-group effect was detected for MESOR or amplitude, and the descriptive acrophase patterns did not provide evidence of treatment-induced restoration or normalization of circadian organization. Maternal pir treatment was associated with higher hippocampal pCREB and BDNF levels in male, but not female offspring relative to the LL-veh group. While the behavioral and molecular differences occurred concurrently in males, these findings do not prove that pCREB/BDNF signaling mediated the behavioral outcomes. Furthermore, the study cannot distinguish the direct developmental effects of maternal pir exposure from those mediated through maternal or offspring circadian rhythm. Therefore, the findings should be interpreted as long-term behavioral and sex-specific molecular differences associated with maternal pir treatment rather than as evidence of circadian-independent antidepressant, anxiolytic, cognitive-enhancing, or BDNF-enhancing actions.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116539"},"PeriodicalIF":2.9,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent chronic social stress induces sex-specific behavioral alterations with limited persistence into adulthood.","authors":"Oscar Vegas, Alina Díez-Solinska, Garikoitz Azkona","doi":"10.1016/j.bbr.2026.116535","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116535","url":null,"abstract":"<p><p>Adolescence is a critical period during which social stress can shape neurobehavioral development, yet how acute stress reactivity relates to behavioral adaptation under repeated threat and to later adult outcomes remains poorly understood. Across two complementary experiments conducted in independent cohorts, we examined acute and repeated social defeat stress in pubertal male and female CD-1 mice to characterize endocrine reactivity, adolescent behavioral adaptation trajectories, and their relationship with adult phenotypes. Acute social defeat elicited robust hypothalamic-pituitary-adrenal axis activation in both sexes, accompanied by a sex-specific progesterone response, with stressed females showing a marked reduction in circulating progesterone. During repeated social defeat, mobility decreased immediately after stress in both sexes, but the accompanying social responses differed: after the first session, males increased body contact and reduced inter-individual distance, whereas females increased inter-individual distance without a detectable change in body contact. Across the 10-day protocol, baseline body contact increased, and inter-individual distance decreased in both sexes, with larger longitudinal changes in females. Principal component analyses confirmed a baseline sex difference driven mainly by greater body contact in females and showed divergent multivariate adaptation trajectories during repeated stress. Adult consequences were selective: previously stressed animals showed reduced open-arm time in the elevated plus maze and lower circulating testosterone, whereas most other adult outcomes were only modestly affected. Associations between adolescent behavioral adaptation and adult outcomes were weak, and none of the developmental-continuity models remained significant after correction for multiple comparisons. These findings suggest that adolescent social stress primarily reorganizes ongoing behavioral strategies, while providing limited evidence for a stable, generalized adult stress phenotype. The results highlight adolescence as a period of considerable behavioral flexibility and identify sex-dependent adaptation trajectories as a central feature of responses to repeated social threat.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116535"},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioural avoidance to imagined conditioned stimuli in differential fear conditioning.","authors":"Sharmili Mitra, Andrew L Lyons, Marzieh Hajiloo, Steven G Greening","doi":"10.1016/j.bbr.2026.116537","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116537","url":null,"abstract":"<p><p>The underlying mechanisms of how a fear is born in our imagination is presently unclear. The current study used differential fear conditioning to assess how a fear is created in one's mind and how behavioural avoidance interacts with imagined fear. This study contained an Acquisition, Behavioural Avoidance, and Transfer phase. During the Acquisition phase, participants combined instructions such that whether they heard \"imagine yellow\" (colour instruction) or \"imagine horizontal\" (orientation instruction) they were to imagine yellow horizontal lines (CS+) and likewise for the \"imagine blue\" and \"imagine vertical\" instructions (CS-). Unbeknownst to participants, they only received the mild shock (US) to the orientation instructions. This manipulation allowed for a disambiguation of descriptive and depictive elements of how imagination interacts with fear. Next, participants completed the Behavioural Avoidance phase, whereby participants had the option to avoid the US after hearing the trial's instructions. Finally, in the Transfer phase, participants were visually shown the CS+ and CS- to determine how their fear transferred from imagery to perception. Self-report, skin conductance response (SCR), and behavioural avoidance attempts were used as dependent measures. Results from each phase and dependent measure suggested that fear was driven by the orientation instructions. Furthermore, fear was shown to transfer from imagery to the corresponding visual stimuli. In this way, these results suggest that both depictive and descriptive elements are involved in the creation of fears in our imagination.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116537"},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of kappa opioid receptor manipulation on the development of methamphetamine-induced locomotor sensitization in adult male and female rats.","authors":"Sarah L Seeley, Madison Snyder, Manoranjan S D'Souza","doi":"10.1016/j.bbr.2026.116530","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116530","url":null,"abstract":"<p><p>Neural substrates playing a role in the development of sensitized behavioral responses after repeated methamphetamine exposure are not fully understood. In this study, we investigated the role of kappa opioid receptors (KORs) in the development of methamphetamine-induced locomotor sensitization, which is used as a rodent model for methamphetamine-induced sensitized behavioral responses. The study was conducted over 28 days using adult male and female rats. Methamphetamine (0.5mg/kg; i.p.)-induced increase in locomotor activity was measured on Days 2 and 28. On Days 3-8, animals were treated with methamphetamine (1mg/kg) injections followed by a period of no drug administration (Days 9-27). Manipulation of KORs was done using the KOR agonist (±U50488; 1.5 & 6mg/kg; s.c.; Days 3-8) or the KOR antagonist (norBNI; 5 & 15mg/kg; s.c.; Day 2) prior to methamphetamine (1mg/kg) treatment on Days 3-8. Difference in total distance travelled on Day 28 from Day 2 after methamphetamine administration was used as measure of methamphetamine-induced locomotor sensitization. Pretreatment with norBNI (15mg/kg but not 5mg/kg) prior to repeated methamphetamine (1mg/kg) treatment (Days 3-8) facilitated development of methamphetamine-induced locomotor sensitization in adult male, but not female rats. In contrast, pretreatment with ±U50488 (6mg/kg or 1.5mg/kg) prior to repeated methamphetamine (1mg/kg) treatment (Days 3-8) did not influence development of methamphetamine-induced locomotor sensitization in either adult male or female rats. Together, the data suggests differential sex-dependent effects of KOR blockade on the development of methamphetamine-induced locomotor sensitization.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116530"},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical early-life ultrasonic vocalizations disrupt the pup-dam communication dyad in the BTBR model of autism spectrum disorder.","authors":"Nicole I Cofsky, Matthew S Binder","doi":"10.1016/j.bbr.2026.116527","DOIUrl":"10.1016/j.bbr.2026.116527","url":null,"abstract":"<p><p>Alterations in early-life communication are a defining feature of autism spectrum disorder (ASD). While these deficits are well conserved in mouse models, few studies have assessed how aberrations in neonatal vocalizations affect maternal behaviors and disrupt the pup-dam communication dyad. To better elucidate the consequences of altered communication in ASD models, we assessed ultrasonic vocalization (USV) production in pups and the corresponding retrieval behaviors in dams using C57 and BTBR (autistic-like) mice. We first used the pup's dam as the retriever and found that BTBR dams retrieved significantly fewer pups than C57 dams. We then used a novel C57 dam as the retriever and found that BTBR pups were retrieved significantly slower than C57 pups. Follow-up analyses detected positive correlations between call duration and retrieval time and amplitude and retrieval time in BTBR pups. Similarly, we found that C57 mice that were retrieved the fastest had calls of a lower amplitude than slowly retrieved mice. In the BTBR model, we found that faster retrieved mice produced shorter calls with a higher pitch than slowly retrieved mice, displaying call characteristics more similar to C57 pups. Lastly, we found that a more diverse call type repertoire was associated with a faster retrieval time. Overall, our study demonstrates that altered USV production significantly affects the pup-dam communication dyad. Furthermore, we identified the USV duration, amplitude, and a more diverse call type repertoire as being critical factors underlying maternal retrieval.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116527"},"PeriodicalIF":2.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From animal behavior to human perioperative neurocognitive disorders: translational boundaries of the gut-brain axis.","authors":"Chi Zhu, Jionglin Wei","doi":"10.1016/j.bbr.2026.116533","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116533","url":null,"abstract":"<p><p>Perioperative neurocognitive disorders (PND), including postoperative delirium (POD), delayed neurocognitive recovery (DNR), and postoperative neurocognitive disorder, are common after surgery in older adults, and the gut-brain axis has been proposed as a contributing pathway. Most mechanistic support rests on rodent behavioral assays, yet these endpoints and human clinical diagnoses are routinely treated as interchangeable. This critical narrative review examines that translational boundary. PND is used here as a clinically consequential test case for a broader behavioral-neuroscience problem: how animal behavioral phenotypes, microbiome-associated signals, and intervention effects should be translated into human diagnostic constructs. A structured search identified and appraised the principal evidence rather than an exhaustive synthesis; no formal risk-of-bias or certainty-of-evidence assessment was performed. Evidence was separated into human perioperative studies reporting a neurocognitive outcome with either a measured gut-brain exposure or a gut-directed intervention; those reporting gut-brain change without a cognitive outcome; perioperative preclinical evidence; and indirect non-perioperative evidence. The retrieved human perioperative evidence spans observational cohorts across gastric, orthopedic, spinal and cardiac surgery, multi-omic and metabolomic cohorts, and randomized perioperative probiotic trials reporting lower rates of study-defined cognitive outcomes. It nonetheless remains heterogeneous and largely single-center, with modest event numbers, inconsistent sampling and assessment, and limited external validation. Mechanistic support still comes mainly from perioperative rodent models using water maze, fear-conditioning, recognition-memory, and delirium-like readouts, which measure narrow, species-specific capacities and are not diagnostic equivalents of POD, DNR, or postoperative neurocognitive disorder. Microbiome-mediated causation is unproven, and cross-species endpoint alignment remains a central route to improved translation.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116533"},"PeriodicalIF":2.9,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Very early treadmill exercise facilitates neuroprotection and functional recovery following cerebral ischemia in rats\" [Behav. Brain Res. 516 (2026) 116469].","authors":"Mohtaram Yazdanian, Mehdi Seydyousefi, Abdorreza Eghbal Moghanlou, Abdullah Demirli, Yunus Sadir, Maryam Nazari, Gerlinde A S Metz, Zeinab Faghfoori","doi":"10.1016/j.bbr.2026.116503","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116503","url":null,"abstract":"","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116503"},"PeriodicalIF":2.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: \"Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease'' [BBR, 336 (2018) pp 219-226].","authors":"","doi":"10.1016/j.bbr.2026.116388","DOIUrl":"10.1016/j.bbr.2026.116388","url":null,"abstract":"","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"514 ","pages":"116388"},"PeriodicalIF":2.9,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure, functions, and mechanisms of Rodentia vocalizations across the lifespan.","authors":"Dami Solaja, Morgan L Gustison","doi":"10.1016/j.bbr.2026.116485","DOIUrl":"10.1016/j.bbr.2026.116485","url":null,"abstract":"<p><p>Vocalizations are an integral way that rodents and many other mammals communicate. Historically, research on rodent vocalizations focused on laboratory-derived strains of two species, house mice (Mus musculus), and brown rats (Rattus norvegicus). However, with over 2000 species, Rodentia is one of the largest vertebrate orders with many species available for communication research. In this review, we synthesize recent findings on lesser-studied species spanning five Rodentia families: Muridae, Caviidae, Cricetidae, Bathyergidae (including Heterocephalidae), and Sciuridae. First, we take an evolutionary perspective to compare adult vocalizations within and across these five Rodentia families. Then, we take a developmental perspective to characterize immature vocalizations and how they transition into mature vocalizations. Next, we explore the potential functions of rodent vocalizations by surveying the behavioural contexts in which they occur. Finally, we summarize recent work on the physiological mechanisms that underpin rodent vocalizations, from biomechanics to neuromodulator systems and neural circuitry. Together, this research shows that Rodentia is an excellent taxonomic group for exploring the diversity and evolution of vertebrate acoustic communication.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116485"},"PeriodicalIF":2.9,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149057796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}