Behavioural Brain Research最新文献

{"title":"The basic theory and application of the mirror neuron system in dysphagia after stroke","authors":"Le Wang,&nbsp;Yi Li,&nbsp;Ruyao Liu,&nbsp;Heping Li,&nbsp;Liugen Wang,&nbsp;Xi Zeng","doi":"10.1016/j.bbr.2025.115430","DOIUrl":"10.1016/j.bbr.2025.115430","url":null,"abstract":"<div><div>The discovery of the brain's mirror neuron system enables researchers to gain a deeper understanding of social cognitive activities from the level of neural mechanisms. Mirror neurons are situated in bilateral brain regions, overlapping with the swallowing neural network, and there are complex network pathways connecting the two. Repeatedly inducing the activation of mirror neurons in stroke patients can enhance the brain's ability to relearn its original swallowing function, and then restore the swallowing neural network. With the deepening of related studies, rehabilitation therapies based on the mirror neuron system have been discussed and explored by numerous scholars and applied to the rehabilitation of dysphagia after stroke. In this paper, we review the basic theory of mirror neuron system, its mechanism, its relevance to the swallowing neural network, and the clinical application and research progress of related rehabilitation therapies in stroke dysphagia, with a view to triggering relevant researchers to comprehend and innovate the rehabilitation of dysphagia after stroke.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"Article 115430"},"PeriodicalIF":2.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoceutical isoquercitrin and ethanolic extracts from pequi (Caryocar coriaceum Wittm) reverse alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio)","authors":"Yatagan M. da Rocha ,&nbsp;Luzia Débora S. Marques ,&nbsp;Gabriela A. do Nascimento ,&nbsp;Maria Rayane C. de Oliveira ,&nbsp;Luiz F. Wemmenson G. Moura ,&nbsp;Daniela Braga de Sousa ,&nbsp;Keciany A. de Oliveira ,&nbsp;Saulo C. Magalhães ,&nbsp;Solange de O. Pinheiro ,&nbsp;Franciglauber S. Bezerra ,&nbsp;Hamilton M. Ishiki ,&nbsp;Kalina Kelma O. de Sousa ,&nbsp;Sacha A.A.R. Santos ,&nbsp;Natália C.G. Vieira ,&nbsp;Antonio E. Vieira-Neto ,&nbsp;Daniela R. Alves ,&nbsp;Wildson Max B. da Silva ,&nbsp;Lucas S. Frota ,&nbsp;Selene M. de Morais ,&nbsp;Larissa M.R. da Silva ,&nbsp;Francisco Ernani A. Magalhães","doi":"10.1016/j.bbr.2025.115439","DOIUrl":"10.1016/j.bbr.2025.115439","url":null,"abstract":"<div><div>Pharmacotherapy in Alcohol Withdrawal Syndrome (AWS), which is a mental disorder, generally involves benzodiazepines due to their action via GABA, but their side effects, such as excessive sedation, mental confusion and risk of dependence, are considerable. It is important to investigate the anxiolytic potential of plants such as <em>Caryocar coriaceum</em>, due to the presence of secondary metabolic compounds, such as isoquercitrin, capable of promoting the reduction of anxiety during AWS. We evaluated the anxiolytic-like potential of ethanolic extracts from the leaves (EEPL) and pulp (EEPP) of <em>C. coriaceum</em>, and its major compound, isoquercitrin (IsoQuer), in adult zebrafish (<em>Danio rerio</em>) during alcohol withdrawal. Adult zebrafish (n = 8 per group) were treated (20 µL; <em>p.o</em>) with EEPL, or EEPP or IsoQuer (0.01 or 0.05 or 0.1 or 0.5 or 1.0 mg/mL) and submitted to the 96-hour acute toxicity test. Flumazenil in adult zebrafish and molecular Docking of IsoQuer were used to investigate the GABAergic involvement. Finally, the anxiolytic-like activity was evaluated during alcohol withdrawal in adult zebrafish. The results indicated that EEPL, EEPP and IsoQuer are safe and have no sedative effect on adult zebrafish. Furthermore, they demonstrated a pharmacological potential in the treatment of alcohol withdrawal-induced anxiety, mediated by the GABAergic system, evidenced in the in-silico study by the stable isoquercitrin-GABA_A complex, the main constituent of the extracts. These findings suggest an anxiolytic herbal potential of <em>C. coriaceum</em> and isoquercitrin, providing an alternative for the treatment of anxiety associated with AWS.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"482 ","pages":"Article 115439"},"PeriodicalIF":2.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequence learning following maternal immune activation","authors":"Tallulah-May R. Patterson,&nbsp;Rebecca E.A. Dunn,&nbsp;David K. Bilkey","doi":"10.1016/j.bbr.2025.115433","DOIUrl":"10.1016/j.bbr.2025.115433","url":null,"abstract":"<div><div>Maternal immune activation (MIA) is a risk factor for schizophrenia. Since memory for sequence and stimulus order are disrupted in individuals with schizophrenia, we tested whether MIA animals showed deficits in a sequence learning and object-place recency memory task. In experiment one, control and MIA-challenged rats were required to nose poke five ports in a cued sequence. The sequences were presented randomly except for one structured sequence that was repetitive and initiated from the same port. Both groups were more accurate on the structured sequence and learned the task at similar rates. When a new structured sequence was presented, control animals were able to respond flexibly and take advantage of the structure, whereas the performance of MIA animals was similar for random and structured sequences. Experiment two tested MIA and control rats were evaluated in a Temporal Ordering for Spatial Locations task (TOSL). Control animals had a significant preference for the object in the least-recent location, indicating a novelty preference, while MIA animals did not, although the between-group difference failed to reach significance. Exploration patterns changed differentially over time, possibly because of variation in habituation processes. As a result, MIA animals were significantly less likely to explore the object at the least-recent location during the second half of the exploration session, compared to control animals. Collectively these studies indicate that while MIA animals are unimpaired in simple sequence learning, they display changes in behaviour compared to controls. Differences may result from habituation rate or inflexibility when responding to change.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"482 ","pages":"Article 115433"},"PeriodicalIF":2.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of TGF-β1 on Aβ-40 and α- β- γ secretase expression in hippocampus and prefrontal cortex in experimental Alzheimer's disease","authors":"Samet Kara ,&nbsp;Sema Polat ,&nbsp;Kübra Akillioglu ,&nbsp;Dilek Saker ,&nbsp;Ahmet Turan Evli̇ce ,&nbsp;Leman Sencar ,&nbsp;Ummuhan Fulden Aydın ,&nbsp;Sait Polat","doi":"10.1016/j.bbr.2025.115432","DOIUrl":"10.1016/j.bbr.2025.115432","url":null,"abstract":"<div><div>Alzheimer's disease is a chronic complex neurodegenerative disease characterized with amyloid plaques and loss of neurons. TGF-β1 is important growth factor, plays critical roles in cell metabolism, tissue homeostasis, neuronal development, and synaptic plasticity. In this study, we aimed to examine the effect of TGF-β1 on the regulation of α, β, and γ-secretase enzymes, Aβ-40 accumulation, apoptosis, and neuronal damage in an experimental Scopolamine-induced AD-like model. The subjects were divided into 5 groups such as control, sham, TGF-β1 control, Scopolamin group, TGF-β1 treatment groups.Then all groups were divided into 2 subgroups according to 28th-56th days. Except for Morris water maze (MWM) test, hippocampus and prefrontal cortex tissues were taken for light-electron microscopic, immunohistochemical, and biochemical examinations. It was observed that learning and memory abilities, which decreased in the MWM test of the Scopolamine group, increased in the treatment groups. In addition, α-secretase expression decreased in the Scopolamin group, while it increased in the TGF-β1 treatment group. It was determined that Aβ-40 and caspase-3 immunoreactivity, β and γ-secretase enzyme levels increased in the Scopolamin group and decreased in TGF-β1 treatment group. Cellular degenerations were relatively decreased in TGF-β1 treatment group. It was thought that TGF-β1 might have a therapeutic effect on Alzheimer's disease by increasing memory performance and preventing Aβ-40 accumulation in the AD-like model induced by Scopolamine and also, may be effective preventing neuronal damage by down-regulating caspase-3 expression. When all the findings evaluated together, it was concluded that TGF-β1 could be evaluated as a therapeutic agent in Alzheimer's disease.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"482 ","pages":"Article 115432"},"PeriodicalIF":2.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-enhanced fear learning can be reduced with unconditional stimulus deflation with constraints.","authors":"Jaden B. Brooks ,&nbsp;Payton K. Robinson ,&nbsp;Sean Warner ,&nbsp;Priya Halder ,&nbsp;Sydney Trask","doi":"10.1016/j.bbr.2025.115438","DOIUrl":"10.1016/j.bbr.2025.115438","url":null,"abstract":"<div><div>Exposure to extreme stress can negatively impact behavior and lead to prolonged fear sensitization. These processes can be studied in the lab using stress-enhanced fear learning (SEFL), where prior exposure to inescapable stress exacerbates later contextual fear conditioning. A common method to reduce conditional fear is through extinction, where a conditional stimulus once paired with an unconditional (US; e.g., a footshock) is presented alone. Previous research shows that extinction learning may not be as effective at reducing fear behavior in rodents previously exposed to stress, mirroring similar extinction impairments observed in aged rodents. Weak-shock exposure (termed US deflation) following conditioning with a strong shock has been proposed to be an alternative to extinction where presentations of weaker versions of the US would work to modify the original fear memory rather than create a new memory as in extinction and thus more precisely target the original context fear memory. While effective under normal conditions, it has yet to be studied how effective US deflation is at reducing stress-enhanced context fear. Here we aimed to test if US deflation could reduce fear in a SEFL paradigm and identify any constraints of this effect. Following 15 inescapable footshocks or matched chamber exposure, male and female Long Evans rats received 1 context-shock pairing or 5 context-shock pairings in a novel context. The next day, they were given either 10 weak footshocks (US deflation) or extinction before behavioral testing. Following training with 1 context-shock pairing, both US deflation and extinction functioned similarly in reducing freezing behavior of stressed rodents. However, following 5 context-shock pairings, only the unstressed rodents displayed a significant decrease in fear behavior, suggesting that prior stress coupled with more robust conditioning can limit the efficacy of US deflation in reducing fear behavior. Finally, we replicated the SEFL effect in aged rodents and found that they showed a significant decrease in stress-enhanced fear learning following US deflation, whereas our previous research showed impairments of traditional extinction in aged rodents. Together, these results suggest that US deflation can reduce SEFL in both adult and aged rodents following a single context-shock pairing, with additional pairings rendering this procedure ineffective at mitigating the effects of prior stress.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"Article 115438"},"PeriodicalIF":2.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrolysin treatment improved short-term memory deficits while simultaneously increasing hippocampal spine density in hypertensive female rats","authors":"Ivette Espinoza ,&nbsp;Ma de Jesús Gómez-Villalobos ,&nbsp;Leonardo Aguilar-Hernández ,&nbsp;Gonzalo Flores ,&nbsp;Julio César Morales-Medina","doi":"10.1016/j.bbr.2025.115436","DOIUrl":"10.1016/j.bbr.2025.115436","url":null,"abstract":"<div><div>Hypertension, if untreated, can disrupt the blood-brain-barrier (BBB) and reduce cerebral flow in the central nervous system (CNS) inducing hippocampal atrophy, potentially leading to cognitive deficits and vascular dementia. Spontaneous hypertensive rats (SHR) demonstrated neuroplastic alterations in the hippocampus, hyperlocomotion and memory deficits in males. Cerebrolysin (CBL), a neuropeptide preparation, induces synaptic and neuronal plasticity in various populations of neurons and repairs the integrity of the BBB. This research aims to investigate the behavioral outcomes in locomotion and recognition memory in the Novel Object Recognition Test (NORT) and assess the neuroreparative effect of CBL on the cytoarchitecture of neurons and the spine density in pyramidal neurons of the prefrontal cortex (PFC), the entorhinal cortex (EC) and the CA1 region of the dorsal hippocampus, as well as spheroidal neurons of the dentate gyrus (DG). Our findings indicate that SHR exhibited elevated diastolic and systolic pressures, and increased locomotion. Importantly, CBL treatment improved recognition memory in SHR strain. Hypertension led to reduced arborization in the EC, CA1, and DG regions. Moreover, CBL treatment increased arborization in both normotensive and hypertensive rats in the CA1, and DG regions of hippocampus and EC and selectively increased spine density in the hippocampus of hypertensive rats. These findings suggest that CBL neurotrophic treatment enhances recognition memory and promotes dendritic growth or spine density, depending on the neurochemical environment within the brain.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"Article 115436"},"PeriodicalIF":2.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking costs in chronic non-specific neck pain patients with high vs. low catastrophizing tendencies compared to healthy controls","authors":"Ibrahim M. Moustafa ,&nbsp;Amal Ahbouch ,&nbsp;Shima Abdollah Mohammad Zadeh ,&nbsp;Tamer Shousha ,&nbsp;Paul A. Oakley ,&nbsp;Deed Harrison","doi":"10.1016/j.bbr.2025.115434","DOIUrl":"10.1016/j.bbr.2025.115434","url":null,"abstract":"<div><div>Chronic non-specific neck pain (CNSNP) is a common condition and its relationship to the pain catastrophizing construct in terms of sensorimotor functions and dual task performance is not fully understood. We aimed to investigate the differences in sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking abilities between CNSNP patients (&gt; 3 months) with high versus low catastrophizing tendencies and healthy controls. Ninety participants were recruited, 30 asymptomatic controls, and 60 patients with CNSNP; 30 scoring high (&gt; 75th percentile) and 30 scoring low (&lt; 25th percentile) on the pain catastrophizing scale (PCS). The variables of sensorimotor integration (frontal N30 amplitude), cervical sensorimotor control (head repositioning accuracy (HRA) - left and right), and cognitive-motor dual tasking (percentage of gait speed time increase with a cognitive load) were assessed and compared across groups. In general, performance of sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking abilities was incrementally better comparing the high to low catastrophizing groups, and the low catastrophizing group to the controls. Correlation coefficients between PCS and HRA (left and right) was strong (r = .8, p &lt; 0.001), between PCS and dual tasking cost was moderate (r = .7, p &lt; 0.001), and between PCS and frontal N30 amplitude was moderate (r = .57, p &lt; 0.001). In conclusion, we found that higher pain catastrophizing was associated with poorer sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking in CNSNP patients highlighting the importance of both assessing and treating catastrophizing in the treatment of CNSNP.</div></div><div><h3>Perspective</h3><div>This study highlights the significant impact of pain catastrophizing on sensorimotor integration, cervical sensorimotor control, and cognitive-motor dual tasking in CNSNP patients. High catastrophizers are particularly vulnerable to these impairments, suggesting the need for comprehensive treatment approaches that address both psychological as well as physical components.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"Article 115434"},"PeriodicalIF":2.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent effects of rat maternal immune activation on motor function in offspring of poly I:C treated rats","authors":"K. Jack Scott ,&nbsp;David K. Bilkey","doi":"10.1016/j.bbr.2025.115431","DOIUrl":"10.1016/j.bbr.2025.115431","url":null,"abstract":"<div><div>A majority of people with schizophrenia will experience motor symptoms such as impairments to coordination, balance and motor sequencing. These neurological soft signs are associated with negative social and functional outcomes, and poor disease prognosis. They occur prior to medication exposure, suggesting they are an intrinsic feature of schizophrenia. Despite the need to better understand this dysfunction, relatively few studies have provided a detailed focus on motor capability in animal models of schizophrenia. Here we investigate motor coordination in a rat maternal immune activation (MIA) model of schizophrenia risk. The female and male offspring of Polyinosinic:polycytidylic acid (Poly I:C), and vehicle-treated, pregnant dams were tested in a horizontal ladder rung task using regular and irregular rung configurations. We extracted information about limb positions from video, and measured faults and gait coordination in the task. We found that adult male MIA rats were more likely to slip from the ladder rungs than control animals, and they were more likely to have multiple limbs slip simultaneously. MIA rats also exhibited more variability in stride length, a result that correlated with slips and mirrored disease-related changes in human gait. In contrast, female MIA rats displayed minimal alterations in motor performance. Our findings show that the ladder task uncovers sex-dependent effects on motor coordination in MIA rats and highlights the potential usefulness of the MIA model for investigating motor dysfunction in an animal model of schizophrenia risk.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"Article 115431"},"PeriodicalIF":2.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal theta oscillation of hippocampal ensemble and memory function","authors":"Lin Sun ,&nbsp;Lihua Bao","doi":"10.1016/j.bbr.2025.115429","DOIUrl":"10.1016/j.bbr.2025.115429","url":null,"abstract":"<div><div>Memory is the ability to acquire and store information following an experience, which can be retrieved by related context exposure. Pioneering studies have demonstrated that sparsely distributed neuronal ensembles or engram cells can serve as neural substrates for storing and recalling memory traces. Many studies of neuronal ensembles have focused on the hippocampus, and increasing evidence has indicated that the neuronal oscillation is closely associated with hippocampal memory functions, including both encoding and retrieval processes. In particular, the theta synchronization of hippocampal ensembles with other brain regions mediates the retrieval of multiple types of memory. The recent progress of theta oscillations in the formation of memory engrams is reviewed, as well as the increased theta power and neurotransmitter regulation on memory function. Detailed information based on an analysis of hippocampal local theta rhythms is presented. Moreover, the hippocampus theta synchronization with the sensory cortex, prefrontal cortex and amygdala, which mediate different types of memory retrieval, are also reviewed. Together, these findings contribute to understanding the important role of hippocampal theta oscillation in the storage and recall of memory traces.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"Article 115429"},"PeriodicalIF":2.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High intensity approaches to exposure and response prevention for obsessive-compulsive disorder","authors":"Erika S. Trent,&nbsp;Robert J. Zhou,&nbsp;Liya Mammo,&nbsp;Wayne K. Goodman,&nbsp;Eric A. Storch","doi":"10.1016/j.bbr.2025.115427","DOIUrl":"10.1016/j.bbr.2025.115427","url":null,"abstract":"<div><div>Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition with multidetermined etiological and maintaining mechanisms. Cognitive behavioral therapy (CBT), specifically exposure and response prevention (ERP), is the first line behavioral intervention to treat OCD. ERP directly targets threat learning that characterizes OCD through processes of habituation (fear extinction) and inhibitory learning, in addition to eliciting neuronal changes implicated in OCD. Although ERP has a strong evidence base, not all OCD patients respond fully to standard, weekly or twice-weekly outpatient ERP. High intensity ERP—treatment delivered through more and/or longer sessions in a condensed manner—is a potential alternative approach that has also demonstrated efficacy for adults and youth with OCD. The goal of this review article is to describe the nature, rationale, and evidence for high intensity ERP for OCD treatment. We describe the foundations of ERP for OCD, various formats of intensive ERP, clinical research on the efficacy of this approach including neuronal changes, and potential pharmacological and neurosurgical augmentation strategies. We conclude with limitations of the current literature on intensive approaches and recommendations for future directions. While additional research is needed, high intensity ERP may be a promising approach for patients who have not responded to standard ERP or for patients requiring rapid symptom improvement.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"481 ","pages":"Article 115427"},"PeriodicalIF":2.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}