Behavioural Brain Research最新文献

{"title":"Effects of High-Intensity Interval Training (HIIT) on miR-29c and miR-146a expression in the hippocampus of streptozotocin-induced diabetic rats","authors":"Mehdi Soltani Ichi,&nbsp;Fatemeh Shabkhiz,&nbsp;Mohammadreza Kordi","doi":"10.1016/j.bbr.2025.115632","DOIUrl":"10.1016/j.bbr.2025.115632","url":null,"abstract":"<div><h3>Background</h3><div>MicroRNAs like miR-146a and miR-29c are potential biomarkers for diabetes, which is linked to brain impairments such as cognitive decline and hippocampal dysfunction due to hyperglycemia and inflammation. This study investigates the effects of high-intensity interval training (HIIT) on hippocampal miR-146a and miR-29c expression and serum TNF-α levels in diabetic rats, highlighting its role in reducing inflammation and improving brain function.</div></div><div><h3>Methods</h3><div>Twenty-four male Wistar rats were divided into four groups: Control (Normal), 1-week diabetes (Diabetes 1 W), 6-week diabetes (Diabetes 6 W), and diabetic HIIT (Diabetes-Exe). Diabetes was induced using streptozotocin (55 mg/kg) and rats with blood glucose &gt; 250 mg/dL were included. HIIT was conducted for six weeks, and hippocampal miR-146a, miR-29c expression, and TNF-α serum levels were assessed using Real-Time PCR and ELISA. TNF-α serum levels were measured as a marker of systemic inflammation.</div></div><div><h3>Results</h3><div>Diabetic rats exhibited decreased miR-146a and increased miR-29c expression in the hippocampus compared to controls. Additionally, TNF-α serum levels were significantly higher in the diabetic groups, indicating an elevated inflammatory state. HIIT in the Diabetes-Exe group resulted in a non-significant change in miR-29c expression and TNF-α serum levels, accompanied by a significant increase in miR-146a expression compared to the Diabetes 6 W group.</div></div><div><h3>Conclusion</h3><div>HIIT exercise may help reduce hippocampal neuronal damage in diabetic rats by modulating miR-146a expression, improving blood glucose control, and reducing inflammation. Although HIIT did not significantly alter miR-29c expression, its potential as an effective non-pharmacological strategy for managing diabetic neuropathy complications cannot be excluded.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"489 ","pages":"Article 115632"},"PeriodicalIF":2.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway","authors":"Yue Liu ,&nbsp;Yun Zhai ,&nbsp;Lili Ma ,&nbsp;Zhi Wang ,&nbsp;Jing Wang ,&nbsp;Bifeng Hu ,&nbsp;Ying Tang","doi":"10.1016/j.bbr.2025.115619","DOIUrl":"10.1016/j.bbr.2025.115619","url":null,"abstract":"<div><div>White matter lesions (WMLs) caused by chronic cerebral hypoperfusion (CCH) are closely related to the activation of microglia. Inhibition of microglia overactivation is considered as a protective strategy for WMLs. Based on its anti-inflammatory properties and clinical benefits, colchicine has become a hot spot in the drug treatment and research of vascular diseases. However, its role in vascular cognitive impairment (VCI) remains unclear. In this study, BCAS model was established to induce CCH, simulate subcortical white matter lesions, and examine the effect of colchicine on WMLs after BCAS. The basic parameters of body weight and blood pressure were monitored. Behavioral evaluation included the Open Field test, Y maze and Morris Water Maze to evaluate the motor ability and cognitive level of mice respectively. The cerebral blood flow was detected by Laser Speckle Imaging (LSI). Transmission Electron Microscopy, LFB staining, corpus callosum MBP and MAG western blot levels, and mouse brain T2-weighted imaging were used to detect demyelination and white matter changes. The expression of IBA1 was determined by immunohistochemistry and western blot, and the correlation between IBA1 staining and behavioral parameters was analyzed. The expression of brain inflammatory factors was detected by Elisa. It was found that colchicine may alleviates VCI through MAPK/NF-κB pathway by means of network pharmacology enrichment analysis from the perspective of inflammation, and the classical inflammatory proteins TAK1, p38, JNK, and p65 of this pathway were subsequently detected in in vivo and in vitro models. The anti-inflammatory spectrum of colchicine, including IL-1β, IL-6, COX2, CD86 and anti-inflammatory effects, were extensively evaluated by RT-qPCR, western blot, wound healing and transwell tests on BV2 microglia stimulated by low concentration of LPS in vitro. This study shows that colchicine can improve the cognitive impairment of BCAS mice, and the specific mechanism is to regulate the inflammation of microglia by inhibiting the classical inflammatory pathway of TAK1/MAPK/NF-κB, thereby reducing WMLs and improving the cognitive impairment behavior.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115619"},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habits and vulnerability or resilience to stress – Impact on depressive disorders","authors":"Amanda Gollo Bertollo ,&nbsp;Milene Zanella Capitanio ,&nbsp;Laysa Anacleto Schuh ,&nbsp;Nandara Pradella ,&nbsp;Zuleide Maria Ignácio","doi":"10.1016/j.bbr.2025.115630","DOIUrl":"10.1016/j.bbr.2025.115630","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is prevalent worldwide and impacts the health and quality of life of millions of people. MDD is a condition influenced by a complex interplay of genetic, psychological and environmental factors. This narrative review examines the roles of stress vulnerability, resilience, and lifestyle habits in shaping the risk of depression, emphasizing holistic approaches that address both biological and environmental factors in mental health management. Vulnerability to stress, influenced by factors such as childhood adversity and personality traits such as neuroticism, increases the probability of MDD. On the other hand, resilience acts as a protective mechanism, reducing stress reactivity and supporting mental health. The main findings suggest that healthy lifestyle habits, including consistent sleep patterns, a balanced diet and regular exercise, play significant roles in increasing resilience and preventing depressive symptoms. Interventions to build resilience, such as emotional skills training and promoting a growth mindset, have been proven effective in reducing depressive symptoms. Overall, the findings suggest that lifestyle modifications combined with psychological strategies to build resilience can significantly reduce depressive disorders. This study advocates for personalized therapeutic strategies that consider the multifactorial nature of depressive disorders, integrating psychological and lifestyle interventions to enhance resilience and mental health.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115630"},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Love addiction symptoms and subjective cognitive complaints: The mediator role of depression and anxiety and the impact of social media use","authors":"Gianpaolo Maggi ,&nbsp;Chiara Giacobbe ,&nbsp;Lorenzo Borrello ,&nbsp;Angelo Barone ,&nbsp;Clara Mastromarino ,&nbsp;Paolo Antonelli ,&nbsp;Gabriella Santangelo","doi":"10.1016/j.bbr.2025.115621","DOIUrl":"10.1016/j.bbr.2025.115621","url":null,"abstract":"<div><div>Love addiction (LA) can lead to adverse psychological, social, and cognitive consequences. However, the relationship between LA symptoms and perceived cognitive function, as well as the contribution of social media use, remains unclear. The present study aimed to unravel the exact nature of these relationships in a large Italian sample using an online questionnaire. We found that individuals with even mild LA symptoms experienced reduced everyday memory ability and more severe cognitive failures during daily activities and at work, compared to those without LA. Psychological symptoms mediated the effect of LA symptoms on perceived cognitive function, with the use of social media as a strong risk factor for LA development. LA deserves more scientific attention to provide clinicians with a clinical framework and spread awareness of its harmful consequences involving cognitive aspects. Awareness should encourage most at-risk individuals to recognize early LA manifestations and seek professional help for mental health care.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115621"},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensing the beauty of interface: Neural oscillatory correlates of visual aesthetic judgment","authors":"Yanci Liu ,&nbsp;Shiyu Zhang ,&nbsp;Zheng Jiang ,&nbsp;Feng Du","doi":"10.1016/j.bbr.2025.115623","DOIUrl":"10.1016/j.bbr.2025.115623","url":null,"abstract":"<div><div>It is critical for manufacturers to assess customers' aesthetic preferences for various interfaces. However, few studies on neural oscillations for aesthetic judgment have yielded inconsistent results. In this study, we explored the EEG oscillations linked to aesthetic judgments using interface materials (from aesthetic to medium and unaesthetic) along with corresponding scrambled images. Present findings showed that theta-band synchronization to interface were significantly higher for aesthetic interfaces than unaesthetic ones during 200–240 ms at the bilateral occipitotemporal electrodes. However, no significant differences in theta-band oscillations were observed between scrambled images of aesthetic and unaesthetic interfaces. During 250–300 ms, similar theta oscillation patterns were found only at the right occipitotemporal electrodes. Meanwhile, during 220–270 ms, aesthetic interfaces induced stronger alpha-beta desynchronization than unaesthetic ones at the left frontal electrodes, and still no such significant differences were observed in scrambled images. These EEG oscillations could serve as valuable real-time indicators for assessing individual aesthetic judgments.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"489 ","pages":"Article 115623"},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-type calcium channel blockade attenuates cue-induced cocaine-seeking in female rats","authors":"Violet M. Kimble ,&nbsp;Eric J. Nunes ,&nbsp;Anjali M. Rajadhyaksha ,&nbsp;Nii A. Addy","doi":"10.1016/j.bbr.2025.115613","DOIUrl":"10.1016/j.bbr.2025.115613","url":null,"abstract":"<div><div>Periods of cocaine abstinence are associated with a high risk of relapse, often triggered by exposure to drug-associated cues. Previous research has implicated L-type calcium channels (LTCCs) in drug-seeking behaviors, yet their role in cue-induced relapse, particularly in females, remains underexplored. This study investigated the effects of LTCC inhibition on cue-induced cocaine-seeking behavior during abstinence in female Sprague-Dawley rats. Following a 10-day cocaine self-administration and a 14-day forced abstinence period, the rats were tested for cue-induced cocaine-seeking after receiving systemic administration of isradipine, a non-selective LTCC inhibitor (0.0 mg/kg, 0.1 mg/kg, 0.4 mg/kg, or 1.2 mg/kg, i.p.). Isradipine significantly reduced cue-induced cocaine-seeking in a dose-dependent manner without affecting cocaine-taking or natural reward-taking or seeking behaviors. Notably, these findings in females were comparable to our prior results observed in males, demonstrating that LTCC inhibition selectively attenuates the impact of cocaine-associated cues across sexes. These results highlight the translational potential of LTCCs as a therapeutic agent to reduce relapse risk in cocaine-dependent individuals. This study underscores the importance of considering sex-specific mechanisms in addiction treatment and calls for further research into LTCCs as a target for relapse prevention.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115613"},"PeriodicalIF":2.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different subregions of the anterior cingulate cortex differentially regulate acute itch-scratching behavior in rats","authors":"Jun-Fei Teng ,&nbsp;Xue-Qiang Hu ,&nbsp;Ya-Min Li ,&nbsp;Xing-Yu Lu ,&nbsp;Juan Yao ,&nbsp;Xuan Li ,&nbsp;Dan-Ni Yin ,&nbsp;Jian-Feng Sui ,&nbsp;Liu Yang ,&nbsp;Ping Wang ,&nbsp;Yue-Ming Xu ,&nbsp;Shu-Lei Liu","doi":"10.1016/j.bbr.2025.115616","DOIUrl":"10.1016/j.bbr.2025.115616","url":null,"abstract":"<div><div>Numerous studies in both humans and rodent models have consistently demonstrated the important role of the anterior cingulate cortex (ACC) in emotion perception, pain processing, memory formation, etc. The ACC can be anatomically subdivided into rostral and caudal subregions, each exhibiting distinct functional profiles. Previous studies have provided robust evidence supporting the involvement of the ACC as a whole in pruritus regulation; however, the specific regulatory effects exerted by the distinct subregions of the ACC on pruritus remain unknown. In this study, we investigated the impact of rostral ACC and caudal ACC neuronal intervention on scratching behavior in rats with acute experimental histaminergic and nonhistaminergic itch. The results demonstrated that activation of ACC neurons occurs during acute itching. Moreover, pharmacogenetic inhibition of the rostral ACC increased acute itch scratching induced by 5-hydroxytryptamine (5-HT), whereas inhibition of the caudal ACC reduced both 5-HT- and Compound 48/80-induced acute itch-scratching behavior. In conclusion, the rostral ACC exerts a negative modulatory effect on itch, whereas the caudal ACC plays a positive modulatory role. Both subregions are implicated in the modulation of nonhistaminergic itch, whereas only the caudal ACC is involved in the modulation of histaminergic itch.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115616"},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of cortical thickness in depression among early-stage Parkinson's disease: A potential neuroimaging indicator for early recognition","authors":"Qin Shen,&nbsp;Changlian Tan,&nbsp;Min Wang,&nbsp;Sainan Cai,&nbsp;Qinru Liu,&nbsp;Xv Li,&nbsp;Yuqing Tang,&nbsp;Haiyan Liao","doi":"10.1016/j.bbr.2025.115622","DOIUrl":"10.1016/j.bbr.2025.115622","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to investigate the early change in cortical thickness and surface area in early-stage depressed PD (dPD) patients, and its associations with severity of depression.</div></div><div><h3>Methods</h3><div>59 patients with dPD, 27 patients with non-depressed PD (ndPD), and 43 healthy controls (HC) were recruited. The dPD patients were subclassified into mild-depressed PD (mi-dPD, n = 24), moderate-depressed PD (mo-dPD, n = 21) and severe-depressed PD (se-dPD, n = 14) subgroups. Structural MRI and surface-based morphometry analysis were applied to compare differences in cortical thickness and surface area among groups, and their correlations with Beck Depression Inventory (BDI) scores were analyzed.</div></div><div><h3>Results</h3><div>Compared with ndPD, dPD exhibited cortical thinning in the dorsolateral prefrontal cortex (dlPFC, mainly involving the left superior frontal and bilateral middle frontal gyri), the right pars opercularis and bilateral lateral occipital gyri. The mean cortical thickness values within these regions negatively correlated with BDI scores. Subgroup analysis revealed that patients with mi-dPD had cortical thinning only in the right middle frontal gyrus, while se-dPD showed cortical thinning more extensively involving the right fusiform gyrus, posterior cingulate gyrus, and pars opercularis. There was no significant change in cortical surface area in either the dPD or its subgroups.</div></div><div><h3>Conclusion</h3><div>Our findings indicated that PD-related depression was associated with decrease of cortical thickness, instead of surface area, of which the patterns correlated with the severity of depression. Cortical thinning in dlPFC, mainly involving the left middle frontal gyrus, may serve as a potential neuroimaging indicator for early recognition of depression in PD patients.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115622"},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal evaluation of open field and string-pulling behaviors in mice","authors":"E.A. Schaeffer ,&nbsp;J.R. Osterlund Oltmanns ,&nbsp;E. Meyer ,&nbsp;N. Campbell ,&nbsp;R. Lake ,&nbsp;D.G. Wallace","doi":"10.1016/j.bbr.2025.115615","DOIUrl":"10.1016/j.bbr.2025.115615","url":null,"abstract":"<div><div>Spontaneous behaviors involve collections of highly organized movement sequences produced on a specific spatial scale. For example, mice exhibit organized movement while establishing a home base in the open field (ambulatory scale) and bimanual coordination while string-pulling (manipulatory scale). Disruptions in the organization of spontaneous behaviors, including home base establishment and string-pulling, have been observed in mouse models of neurological disorders. The influence of age on the organization of these behaviors is yet to be determined. The current study evaluated longitudinal changes in the organization of mouse open field movement under completely dark conditions and string-pulling movement at multiple timepoints from 10 to 20 months of age. Topographic and kinematic characteristics of movement were used to investigate age-related changes in ambulatory (i.e., home base stability) and manipulatory (i.e., reaching consistency) scale movement organization. In the open field, general locomotion and home base measures remained stable. However, changes in heading and movement scaling varied with age. In contrast, string-pulling performance varied in measures of accuracy and kinematics, with general improvements observed with age. These results suggest minimal age-related decline in the organization of spontaneous behaviors. As mouse models are commonly used to model progressive diseases in humans, it is important to consider the translatability of aging. This work provides a foundation to characterize the effect of age and compounding variables (e.g., sleep fragmentation, exercise) on spontaneous behaviors.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115615"},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GPR171 is necessary for normal physiological functions and mood-related behaviors in males, but not females","authors":"Megan C. Raddatz ,&nbsp;Callie M. Newson ,&nbsp;Mitchel Stott ,&nbsp;Colton Campbell ,&nbsp;Erin N. Bobeck","doi":"10.1016/j.bbr.2025.115618","DOIUrl":"10.1016/j.bbr.2025.115618","url":null,"abstract":"<div><div>GPR171 is a recently deorphanized G protein-coupled receptor that has been implicated in feeding, mood regulation, and pain. However, the role of this receptor in other physiological functions and in female mice is largely unexplored. Using a novel genetic GPR171 knockout mouse model, we examined general physiological behaviors and mood-related behaviors in both sexes. In male GPR171 knockout mice, we observed increased feeding, reduced water intake, heightened ataxia, and decreased anxiety-like behaviors. Male GPR171 knockout mice showed greater depressive-like behaviors compared to female knockout mice, but this did not correspond to a change in cFos activity in the basolateral amygdala. No significant changes were detected in female GPR171 knockout mice in other behaviors measured. These findings corroborate previous studies linking GPR171 to feeding and mood regulation in males, but highlight notable sex differences that were previously unknown. These sex differences indicate that future studies should focus on elucidating the behavioral effects of GPR171 in females to provide a more comprehensive understanding of its physiological roles.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115618"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}