Behavioural Brain Research最新文献

{"title":"Sex differences in sucrose-induced locomotor sensitization and cross-sensitization with the D2/D3 agonist quinpirole in rats","authors":"Vangel Matic ,&nbsp;Matthew Huynh ,&nbsp;Indra R. Bishnoi ,&nbsp;Martin Kavaliers ,&nbsp;Klaus-Peter Ossenkopp","doi":"10.1016/j.bbr.2025.115771","DOIUrl":"10.1016/j.bbr.2025.115771","url":null,"abstract":"<div><div>In humans, women are known to have a greater prevalence of eating-related disorders and stronger experience of food cravings than men. Similarly, in rodents, females display a greater preference and motivation for the highly palatable sweet food, sucrose, than do males. Pre-exposure to sucrose has been shown to enhance locomotor sensitization induced by dopaminergic agonists, however, evidence of sex differences in this effect is limited. Female (n = 16) and male (n = 16) Long-Evans rats received 30 min daily access to sucrose (0.3 M) or water for nine consecutive days followed by daily administration of the D2/D3 agonist, quinpirole (0.5 mg/kg), for nine consecutive days. Automated locomotor activity assessment occurred on the first, fifth, and ninth days of the sucrose and quinpirole phases. In the sucrose phase, sex × fluid interactions were broadly observed in activity measures across and within testing days with females but not males showing an effect of sucrose-induced locomotor sensitization. In the quinpirole phase, a sex × fluid interaction was only observed in a single activity measure across days, suggesting that sucrose pre-exposure does not robustly alter quinpirole sensitization by sex. A sex difference was identified in the effect of locomotor sensitization induced by sucrose, but not for sucrose pre-exposure on quinpirole sensitization. These results suggest that differences exist between sexes in sucrose-induced sensitization in rodents, perhaps underlying sex differences in food cravings and eating-related disorder prevalence in humans.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115771"},"PeriodicalIF":2.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How we stumbled upon the rat play vocalizations: A recollection","authors":"Brian Knutson","doi":"10.1016/j.bbr.2025.115773","DOIUrl":"10.1016/j.bbr.2025.115773","url":null,"abstract":"<div><div>Over a quarter of a century later, most rodent researchers know that specific types of rat Ultrasonic Vocalizations (USVs) appear to index distinct affective states endowed with arousal, value, and motivational force. Few know the story, however, of how we accidentally stumbled upon 50 kilohertz (50 kHz) USVs in the context of rat play by turning the wrong dial on a bat detector, which I recollect here. The tale of that mistake highlights the critical roles of serendipity, preparation, openness, persistence, and a supportive environment in scientific discovery.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115773"},"PeriodicalIF":2.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive response to fearful faces in mothers","authors":"Anne Bjertrup ,&nbsp;Julian Macoveanu ,&nbsp;Kamilla Miskowiak","doi":"10.1016/j.bbr.2025.115766","DOIUrl":"10.1016/j.bbr.2025.115766","url":null,"abstract":"<div><div>Emerging evidence highlights distinct neurocognitive adaptations during pregnancy and motherhood. This study investigated neural and cognitive responses to adult emotional expressions, focusing on fear and happiness, in 35 mothers with four-month-old infants and 19 control women without young children. Participants completed computerized tasks assessing accuracy in recognizing emotional facial expressions and underwent functional magnetic resonance imaging while viewing fearful and happy adult faces. Compared to control women, mothers demonstrated heightened neural activation to fear versus happiness in occipital and orbitofrontal cortex, regions implicated in visual attention, emotional salience and emotion regulation, respectively. At a behavioural level, no differences in discrimination accuracy were observed between groups. However, greater activation in the orbitofrontal cortex to fearful faces in mothers correlated with higher sensitivity toward their infants during interactions. The findings suggest that enhanced neural vigilance to fear-related cues in mothers may be an adaptive mechanism supporting caregiving behaviour.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115766"},"PeriodicalIF":2.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-23b regulation of metabolites in neuropathic pain: A novel approach","authors":"Shu-Jing Hao ,&nbsp;Yu-Ying Zhao ,&nbsp;Zi-Jun Wu ,&nbsp;Meng-Yao An ,&nbsp;Cheng-Cheng Song ,&nbsp;Jing Li","doi":"10.1016/j.bbr.2025.115768","DOIUrl":"10.1016/j.bbr.2025.115768","url":null,"abstract":"<div><h3>Background</h3><div>MiR-23b has been shown to be involved in a range of neurological disorders and in regulating inflammation and metabolism. However, studies on the role of miR-23b in neuropathic pain (NP) are limited. This study aimed to investigate whether miR-23b could enhance the progression of NP by regulating metabolites.</div></div><div><h3>Methods</h3><div>Mechanical and thermal pain thresholds were determined in sham, CCI (chronic constriction injury), and KO-CCI mice. Hematoxylin and eosin staining was used to observe morphological changes in the sciatic nerve. Untargeted metabolomics was employed to analyse the changes in metabolic levels in the serum. Furthermore, a significantly decreased metabolite, betaine, was administered intraperitoneally to both sham and CCI mice to determine its effect on the activation level of microglia using immunofluorescence staining.</div></div><div><h3>Results</h3><div>After the knockout of miR-23b, the paw withdrawal threshold and thermal threshold significantly decreased, indicating an exacerbation of pain and increased infiltration of inflammatory cells in the sciatic nerve. Metabolomic analysis revealed alterations in various metabolites following the miR-23b gene knockout. Following betaine treatment, the activation level of microglia in CCI mice showed a decline.</div></div><div><h3>Conclusion</h3><div>This study shows that removing miR-23b notably affects metabolic levels, worsening NP in CCI mice. It also explores the possible therapeutic roles of miR-23b in NP.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115768"},"PeriodicalIF":2.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the neural correlates of social cognition and emotion recognition in cannabis users: A systematic review of neuroimaging studies","authors":"Christophe Romein ,&nbsp;Mika Mautner-Rohde ,&nbsp;Karis Colyer-Patel ,&nbsp;Helle Larsen ,&nbsp;Janna Cousijn","doi":"10.1016/j.bbr.2025.115755","DOIUrl":"10.1016/j.bbr.2025.115755","url":null,"abstract":"<div><div>Social factors significantly influence the initiation and progression of cannabis use and cannabis use disorder. Although cannabis is the most widely used drug globally, its social cognitive aspects and neural correlates have rarely been studied. To evaluate the findings to date and to guide future research, this systematic review assesses neuroimaging evidence on the associations between long-term cannabis use, social cognition, and emotion recognition. Findings from 8 studies on social cognition suggest an increased neural response to social influence and a decreased neural sensitivity to social exclusion, psychosocial stress, and social reward. However, these results should be interpreted with caution, and further replication is necessary due to the limited number of studies in each area. The findings from 21 studies on emotion recognition remain largely inconsistent. Specifically, regarding the amygdala, cingulate cortex, and frontal areas, findings vary, with certain studies reporting increased activity in response to affective stimuli in cannabis users compared to controls, while other studies reported the opposite effect. These effects could be caused by methodological and sample differences across the studies on emotion recognition. Overall, the functional implications, the causal relationship with use, and the role of individual user characteristics, such as the severity of CUD symptoms, gender, and age remain unclear. Future research should involve larger, more diverse samples and specifically target individuals with CUD. Especially, longitudinal studies focusing on social motivational processes, the brain, and the roles of age and gender as potential moderators could provide valuable insights.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115755"},"PeriodicalIF":2.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does prefrontal cortex oxygenation mediate executive function during high-intensity exercise? A systematic review of fNIRS studies","authors":"Myungjin Jung","doi":"10.1016/j.bbr.2025.115765","DOIUrl":"10.1016/j.bbr.2025.115765","url":null,"abstract":"<div><div>The transient hypofrontality hypothesis posits that cognitive resources are deprioritized in favor of motor demands during extreme physical stress, potentially reducing prefrontal cortex (PFC) activation and impairing executive function (EF). Although prior studies have attempted to investigate the effects of PFC oxygenation, measured via functional near-infrared spectroscopy (fNIRS), on EF during high-intensity exercise, the results remain inconclusive. This systematic review examined whether PFC oxygenation plays a mechanistic role in changes in EF performance during high-intensity exercise, focusing on insights from fNIRS studies employing dual-task paradigms. Following PRISMA guidelines, a comprehensive literature search across five electronic databases identified 523 studies, of which five met the inclusion criteria and were included in the final synthesis. All included studies employed dual-task paradigms in which EF was assessed concurrently with high-intensity exercise. Some studies reported EF impairments associated with reduced PFC oxygenation during high-intensity exercise, while others observed stable or increased PFC oxygenation, without significant EF impairments. These inconsistencies may arise from methodological variations, extracerebral confounders, and individual differences. The findings highlight PFC oxygenation as a critical yet context-dependent factor in EF regulation but suggest it may not directly mediate cognitive impairments under such dual-task paradigms. This review supports the need for standardized dual-task protocols, advanced neuroimaging techniques, and multi-modal approaches to better understand the role of PFC oxygenation in the transient hypofrontality effect.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115765"},"PeriodicalIF":2.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute MK-801 induces hyperactivity and changes spatio-temporal exploratory dynamics without disrupting homebase retention in adult zebrafish","authors":"Khadija A. Mohammed ,&nbsp;João V. Borba ,&nbsp;Cássio M. Resmim ,&nbsp;Camilla W. Pretzel ,&nbsp;Allan V. Kalueff ,&nbsp;Julia Canzian ,&nbsp;Barbara D. Fontana ,&nbsp;Denis B. Rosemberg","doi":"10.1016/j.bbr.2025.115767","DOIUrl":"10.1016/j.bbr.2025.115767","url":null,"abstract":"<div><div>The N-methyl-D-aspartate receptor (NMDA_R) antagonist dizocilpine (MK-801) modulates locomotor functions and disrupts cognitive and spatial processes, making it useful for examining pharmacologically-induced behavioral phenotypes that mimic schizophrenia. Here, we investigated the impact of MK-801 on spatio-temporal exploratory dynamics in adult zebrafish, focusing on homebase behavior in the open field test (OFT). In Experiment 1, zebrafish received an intraperitoneal (<em>i.p.</em>) injection of saline or MK-801 (2.0 mg/kg), followed by a 15-min absorption period prior to a 30-min OFT. Experiment 2 involved an initial 30-min OFT, immediate saline or MK-801 (2.0 mg/kg), <em>i.p.</em> administration, and a retrial in the OFT 24 h later. Overall, MK-801 induced hyperactivity and stereotypy in Experiment 1. Although zebrafish were able to establish a homebase as a functionally relevant spatial reference, notable alterations in homebase-related behaviors were observed. Experiment 2 explored the homebase conservation across repeated OFT sessions, revealing that despite subtle changes in overall exploration and homebase occupancy, both groups demonstrated significant homebase conservation and reduced thigmotaxis in the retrial. An inhibitory avoidance task was also performed to confirm the amnesic effects of MK-801 on zebrafish (Experiment 3), revealing impaired aversive memory consolidation. Our novel findings indicate that while MK-801 altered movement patterns and disrupted aversive memory, zebrafish core spatial behaviors remained intact, highlighting the adaptive value of homebase as a conserved spatial strategy. Collectively, this work further supports the utility of zebrafish models for studying how pharmacological modulations of NMDA_R affect spatial orientation and exploratory behavior, with translational relevance to neuropsychiatric diseases.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115767"},"PeriodicalIF":2.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of nicotine on sleep in female C57BL/6J mice","authors":"Sidney Aki ,&nbsp;Morgan Brown ,&nbsp;Jerry Stitzel ,&nbsp;Hunter Mathews","doi":"10.1016/j.bbr.2025.115754","DOIUrl":"10.1016/j.bbr.2025.115754","url":null,"abstract":"<div><div>Sleep disturbances during nicotine withdrawal are well-documented and strongly linked to relapse. While previous studies, including our lab’s work in male mice (Mathews &amp; Stitzel, 2019), have characterized the effects of nicotine exposure and abstinence on sleep, potential sex differences remain unclear. Given that biological sex influences both nicotine addiction and sleep regulation, understanding its role in withdrawal-induced sleep disturbances is critical.</div><div>This study examines the effects of nicotine exposure and abstinence on sleep in female C57BL/6 J mice using EEG/EMG recordings to assess sleep architecture and spectral power. Mice underwent chronic oral nicotine self-administration followed by abstinence, allowing for a detailed analysis of NREM and REM sleep metrics, sleep fragmentation, and EEG spectral power. Nicotine access significantly reduced total sleep time and NREM sleep while increasing sleep fragmentation and REM bout duration. During abstinence, females exhibited persistent NREM fragmentation, a hallmark of withdrawal-induced sleep disruption linked to hyperarousal and relapse vulnerability. Additionally, spectral power analyses revealed that nicotine exposure and abstinence strongly influenced EEG spectral patterns when examined by vigilance state, with the most pronounced alterations occurring during NREM and REM sleep.</div><div>Compared to males from our previous study, female mice displayed a more robust sleep fragmentation phenotype during abstinence, suggesting heightened sensitivity to withdrawal-induced sleep disturbances. These findings emphasize the importance of sex-specific mechanisms in nicotine addiction and support targeting withdrawal-related sleep disruptions to improve relapse prevention strategies for nicotine use disorder.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115754"},"PeriodicalIF":2.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal adenosine A1 and A2A receptor imbalance is associated with anxiety-like behavior in carioca high- and low-freezing rats","authors":"Vanessa Gama Goulart ,&nbsp;Yasmin Oliveira-Nazareth ,&nbsp;Sofia Latgé-Tovar ,&nbsp;Flávia P. Rossetti ,&nbsp;Silvia Maisonnette ,&nbsp;Pablo Pandolfo ,&nbsp;J. Landeira-Fernandez ,&nbsp;Paula Campello-Costa","doi":"10.1016/j.bbr.2025.115751","DOIUrl":"10.1016/j.bbr.2025.115751","url":null,"abstract":"<div><div>Data from clinical studies implicate adenosine in different types of anxiety disorders. Pharmacological and genetic manipulation of A1 and A2A adenosine receptors (A1R and A2AR) suggest that each contributes separately to regulating anxious states. This study aimed to perform a comparative neurochemical analysis of these receptors in animal models with a genetic basis of anxiety. Male Wistar rats previously selected through the freezing paradigm and characterized as high (CHF) and low (CLF) anxiety-like responses were compared to the control group (CTL). Animals were submitted to behavioral tests to evaluate anxiety-like behavior and declarative memory, and to biochemical and immunohistochemical analyses to evaluate the level and localization of A1R and A2AR in the hippocampus. In the elevated plus-maze, the CHF group was more anxious than the control and CLF groups. No statistical differences were found in the object recognition task among groups. Biochemical analyses showed a significant increase in A1R content for CHF in the dorsal hippocampus compared to the control group. On the other hand, the ventral hippocampus presented a decrease in A1R level for CHF and an increase for CLF compared to the control group. Concerning A2AR, data showed that the CLF group presented an increase in the dorsal hippocampus and a decrease in the ventral hippocampus compared to the control group. Together, these results support the hypothesis that the differential level of adenosine receptors in the hippocampus may modulate different aspects of anxiety-like behavior.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115751"},"PeriodicalIF":2.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sensory modality and tempo of stimuli on behavior and cerebral activities during rhythmic production and perception","authors":"Anaïs Desbernats ,&nbsp;Anthony Guedes ,&nbsp;Mélodie Matrat ,&nbsp;Mélanie Jucla ,&nbsp;Joseph Tisseyre ,&nbsp;David Amarantini ,&nbsp;Jessica Tallet","doi":"10.1016/j.bbr.2025.115757","DOIUrl":"10.1016/j.bbr.2025.115757","url":null,"abstract":"<div><div>Sensorimotor synchronization (SMS) is a natural human behavior associated with the perception of predictable, isochronous and environmental rhythmic stimuli. The main objective of this study is to test the conditions that improve the behavioral stability and accuracy of rhythmic SMS. We tested the interaction between different sensory modalities and tempos on the behavior and cerebral activities related to the production and perception of rhythmic stimuli. To this aim, participants were required to produce a SMS and continuation task (production task) and a perception task with 4 modalities (unimodal auditory stimuli, unimodal visual stimuli, bimodal audio-visual congruent – presented simultaneously – or bimodal audio-visual incongruent – presented non-simultaneously – rhythmic stimuli) and 3 different tempos (500 ms, 700 ms and 900 ms). Firstly, both auditory and congruent audiovisual modalities led to more stable SMS compared to the visual modality. Compared to the SMS with incongruent audiovisual modality, SMS with the congruent audiovisual modality led to higher EEG spectral power in the α frequency band over the superior parietal cortex, suggesting lower involvement of attentional/cognitive processes. Secondly, compared to 500 ms, the 900 ms tempo led to the most stable SMS and higher EEG spectral power relative to sensorimotor and attentional/cognitive processes during both SMS and perception. Thirdly, the SMS was the least stable for the 500 ms tempo and for the visual modality. Our results highlight higher stability of SMS and/or lower involvement of sensorimotor and attentional processes for the slowest required tempo (here, 900 ms) and for congruent audio-visual stimuli, suggesting that these conditions are optimal for rhythmic production. These findings provide new cues to understanding the effects of rhythmic-based interventions, especially in the context of sports training and rehabilitation programs.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"495 ","pages":"Article 115757"},"PeriodicalIF":2.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}