Behavioural Brain Research最新文献

{"title":"Effects of sex and estrous cycle on action-outcome contingencies","authors":"Claire M. Corbett ,&nbsp;Samantha L. Bozarth ,&nbsp;Elizabeth A. West","doi":"10.1016/j.bbr.2024.115317","DOIUrl":"10.1016/j.bbr.2024.115317","url":null,"abstract":"<div><div>Goal-directed and habitual-like behaviors are both necessary to efficiently and effectively navigate the environment. A dysregulation between these behaviors can lead to an overreliance on habitual-like behaviors and may contribute to symptoms experienced in some neuropsychiatric disorders such as substance use disorder. One behavioral task used to evaluate goal-directed and habitual-like behavior is an action-outcome task, contingency degradation, where an action (i.e., lever press) is degraded by decoupling the receipt of a reward from the action. However, little is known about how male and female rats and females across the estrous cycle respond during contingency degradation training and extinction testing. Here, we investigated how the variable of sex and estrous cycle influences contingency degradation training and extinction testing and the correlation between baseline anxiety-like behaviors and performance on contingency degradation extinction testing in adult male and female Long-Evans rats. We found that both males and females learned the contingency degradation task. However, during extinction testing, males respond more to the contingent lever than the non-contingent lever while females do not differ in their responses on the non-contingent and contingent levers. Lower baseline anxiety-like behavior predicted better performance on the contingency degradation test in males, but not females. Next, when we examined performance during extinction testing in females based on their estrous cycle stage on test day, we found that females in the proestrus and estrus stages of the estrous cycle do not differ in their responses on the non-contingent and contingent levers, while females in the metestrus and diestrus stages of the estrous cycle respond more on the contingent lever than the non-contingent lever on the extinction test day, similar to male rats. Our findings indicate that the estrous cycle influences how female rats respond during contingency degradation extinction testing that is dependent on their estrous cycle stage.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115317"},"PeriodicalIF":2.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic unpredictable stress during adolescence exerts sex-specific effects on depressive-like behavior and neural activation triggered by tail suspension test","authors":"Wenjing Hu ,&nbsp;Lifang Jiang ,&nbsp;Qiyuan Wang,&nbsp;Qijiang Hu,&nbsp;Tianfeng Zhong,&nbsp;Jian Wu,&nbsp;Xiao Chen,&nbsp;Tao Liu","doi":"10.1016/j.bbr.2024.115314","DOIUrl":"10.1016/j.bbr.2024.115314","url":null,"abstract":"<div><div>During adolescence, acute stress can modify neuronal excitability in various brain regions, leading to negative behavioral outcomes. However, the impact of chronic stress during adolescence on neuronal responses to acute stimuli remains unclear. To address this, we subjected adolescent mice to 12 days of chronic unpredictable stress (CUS). Anxiety and depressive behaviors were evaluated, along with changes in c-Fos expression, which is one of the most widely used markers of neuronal activation. By comparing c-Fos immunoreactivity between the CUS and control groups both before and after the tail suspension test (TST), we found that adolescent CUS induced depressive behaviors in male mice, but not in female mice. Adolescent CUS primarily affected the excitability of neurons in the infralimbic cortex (IL), the dorsomedial and dorsolateral area of the bed nucleus of the stria terminalis (BNST), and the ventral hippocampus CA3. TST exerted a significant main effect on the density of c-Fos⁺ neurons in the prelimbic cortex (PL), infralimbic cortex (IL), cingulate areas 1 and 2 (Cg1, Cg2), the lateral septum (LS), BNST, and lateral habenular (LHb). Furthermore, the excitability of neurons in the paraventricular thalamic nucleus (PVT) was impacted by sex. These data suggest that adolescent CUS elicits region- and sex-specific modifications in TST-induced c-Fos expression, establishing a theoretical basis for understanding the pathophysiological alterations in mood disorders following adolescent stress.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115314"},"PeriodicalIF":2.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of chronic and intermittent administration of taurine on alcohol binge drinking in male rats","authors":"Gabriela Adriany Lisboa Zilli ,&nbsp;Bruna Haendchen Sant’Ana ,&nbsp;Caroline da Silveira Bastiani ,&nbsp;Lucas dos Reis Izolan ,&nbsp;Rianne Remus Pulcinelli ,&nbsp;Douglas Marques ,&nbsp;Mirna Bainy Leal ,&nbsp;Rosane Gomez","doi":"10.1016/j.bbr.2024.115316","DOIUrl":"10.1016/j.bbr.2024.115316","url":null,"abstract":"<div><div>Episodic consumption of high doses of alcohol in a short period (binge drinking - BD) among adolescents is known to be harmful to their brain development. Chronic use of taurine increases voluntary alcohol consumption and shows an anxiolytic-like effect in rats. In this study, we evaluated the differential effects of chronic and intermittent taurine administration on alcohol consumption and behavioral changes in adolescent and young adult rats subjected to the BD model. Male Wistar rats (35 days old) were divided into 4 groups for daily intraperitoneal administration of saline (SAL); taurine, 100 mg/kg (TAU); taurine on BD days and saline on intervals (TAU/SAL); and saline on BD days and taurine on intervals (SAL/TAU). They were exposed to 4 cycles of BD, with free access to alcoholic solution (20 % w/v), for 2 h, 3 days per week. At the end of the 3rd cycle, anxiety-like behaviors were assessed using the light-dark task. After euthanasia, plasma and prefrontal cortex samples were collected to measure corticosterone and BDNF levels, respectively. Chronic taurine treatment did not alter alcohol consumption in rats, whereas intermittent administration increased alcohol intake after 4 BD exposures (TAU/SAL: +19.4 % and SAL/TAU: +21.6 %). No anxiolytic-like effects were found by taurine administration, nor were there changes in serum corticosterone or BDNF levels in the frontal cortex of young adult rats. Intermittent taurine, but not chronic treatment, increased alcohol intake among rats after the second week of exposure. The translation of these results to humans is concerning since the combination of alcohol and drinks containing taurine is common among adolescent and young adult individuals.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115316"},"PeriodicalIF":2.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of repeated voluntary oral consumption of synthetic delta-9-tetrahydrocannabinol on locomotor activity and cannabinoid receptor 1 expression","authors":"Dylan A. Laux,&nbsp;Miki C. Azuma,&nbsp;Mary E. Cain","doi":"10.1016/j.bbr.2024.115315","DOIUrl":"10.1016/j.bbr.2024.115315","url":null,"abstract":"<div><div>As cannabis legalization expands, preclinical studies continue to investigate the impact of repeated exposure to delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in the plant. With the increasing popularity of cannabis infused foods, the rise of THC in medicinal applications have also expanded. The present study addresses a critical gap in existing literature by investigating the behavioral and neurobiological effects of low-dose edible THC in a preclinical rodent model. Adult male rats were administered synthetic-THC (Dronabinol) (0.0625 mg/kg, 0.125 mg/kg, and 0.25 mg/kg) or vehicle (sesame oil) through edible cookies, 90 min prior to eight locomotor sessions. Locomotor activity significantly increased in both 0.0625 mg/kg and 0.25 mg/kg THC groups, indicating a dose-dependent relationship. Repeated 0.25 mg/kg THC administration dose-dependently reduced cannabinoid receptor 1 expression in the hippocampus. The observed neurobiological change from low dose oral THC advances our understanding of repeated cannabis use. These findings also emphasize the importance of refining rodent models for translational relevance.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115315"},"PeriodicalIF":2.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology integrated with pharmacological evaluation for investigating the mechanism of resveratrol in perimenopausal depression","authors":"Ye Zhang ,&nbsp;Li Gui ,&nbsp;Yan Yin ,&nbsp;Xiaona Tong ,&nbsp;Guobin Xia ,&nbsp;Yuanyuan Wang ,&nbsp;Jingting Yi ,&nbsp;Chunyan Tian ,&nbsp;Xiaobo Liu ,&nbsp;Hongling Yang","doi":"10.1016/j.bbr.2024.115304","DOIUrl":"10.1016/j.bbr.2024.115304","url":null,"abstract":"<div><div>Perimenopause constitutes a pivotal transitional phase characterized by hormonal variability and heightens vulnerability to depressive episodes. This study seeks to elucidate the mechanism of resveratrol (RES) in perimenopausal depression through integrated network pharmacology, molecular docking analysis, and experimental validation. Screening yielded 83 RES-related disease targets, with IL10, CCL2, and SERPINE1 identified as core genes overexpressed in perimenopausal depression. GO analysis and KEGG pathway enrichment analysis predicted that the target genes could regulate the PI3K-Akt, FoxO, HIF-1, and IL-17 signaling pathways. Molecular docking indicated SERPINE1 as a promising RES target. Consistently, <em>in vitro</em> experiments showed that RES significantly attenuated the inflammatory response and apoptosis of lipopolysaccharide-stimulated CTX-TNA2 cells. RES also reduced the expression of NLRP3, caspase-1, SERPINE1 proteins and acetylation, while increasing the expression of BDNF, TrkB, SIRT1, and decreasing MAO-A proteins. <em>In vivo</em> experiments demonstrated that RES also significantly improved the depression behaviors, increased the levels of 5-HT1A and SIRT1, and decreased levels of MAO-A of depression rats. This study unveils RES's potential targets and mechanism in perimenopausal depression, laying groundwork for future research.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115304"},"PeriodicalIF":2.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in exploratory behavior of rats successfully performing the object-in-place recognition memory test","authors":"Dan L. McElroy,&nbsp;John G. Howland","doi":"10.1016/j.bbr.2024.115303","DOIUrl":"10.1016/j.bbr.2024.115303","url":null,"abstract":"<div><div>Male and female rodents display unique search strategies when exploring new and familiar environments. Sex differences are well-documented in the literature and may be observed in tasks that rely on spontaneous exploration (e.g., recognition memory tests). Therefore, we assessed patterns of male and female rat behavior in the object-in-place (OiP) test, a common recognition memory paradigm involving object-location associations. Twelve male and 12 female adult Long Evans rats were tested four times in the 1-h OiP test and exploratory behaviors were compared during habituation, sample, and test phases. Results revealed that females moved faster and farther than males, showed increased immobility frequency and reduced immobility duration, reduced outer zone mobility duration, and increased inner zone entrances, compared to males during habituations. During sample phases, female rats moved faster than males, displayed reduced immobility frequency in the inner zone, and demonstrated consistent distance travelled across repeated sessions; conversely, male rats moved less in later sessions and exhibited increased mobility frequency in the outer zone. Analyses comparing test phase behavior revealed females continued to move faster than males; however, no other sex differences were observed. These findings are consistent with previous literature highlighting unique sex differences in explorative behaviors during recognition testing. Sex differences in locomotion and mobility state behaviors may be more indicative of individual motivation and search strategy between the sexes and less indicative of recognition memory.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115303"},"PeriodicalIF":2.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new 2-hit model combining serine racemase deletion and maternal separation displays behavioral and cognitive deficits associated with schizophrenia","authors":"Caroline Lahogue,&nbsp;Michel Boulouard,&nbsp;François Menager,&nbsp;Thomas Freret,&nbsp;Jean-Marie Billard,&nbsp;Valentine Bouet","doi":"10.1016/j.bbr.2024.115301","DOIUrl":"10.1016/j.bbr.2024.115301","url":null,"abstract":"<div><div>Schizophrenia (SCZ) is a multifactorial psychotic disorder characterized by positive and negative symptoms as well as cognitive impairments. To advance the current treatments, it is important to improve animal models by considering the multifactorial etiology, thus by combining different risk factors. The objective of our study was to explore in a new mouse model, the impact of genetic deletion of <em>serine racemase</em> (genetic vulnerability) combined with an early stress factor induced by maternal separation (early environmental exposure) in the context of SCZ development. The face validity of the model was assessed through a wide range of behavioral experiments. The 2-hit mice displayed an increased locomotor activity mimicking positive symptoms, working memory impairment, cognitive deficits and recognition memory alterations, which could reflect neophobia. This new multifactorial model therefore presents an interesting phenotype for modelling animal model with partial behavioral and cognitive deficits associated with SCZ.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115301"},"PeriodicalIF":2.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dopamine transporter inhibition using GBR 12909 as a novel pharmacological tool to assess bipolar disorder-like neurobehavioral phenotypes in zebrafish","authors":"Julia Canzian ,&nbsp;João V. Borba ,&nbsp;Cássio M. Resmim ,&nbsp;Khadija A. Mohammed ,&nbsp;Camilla W. Pretzel ,&nbsp;Isaac A. Adedara ,&nbsp;Denis B. Rosemberg","doi":"10.1016/j.bbr.2024.115302","DOIUrl":"10.1016/j.bbr.2024.115302","url":null,"abstract":"<div><div>Dopamine (DA) is a neurotransmitter that plays an important role in brain physiology. Changes in DA-mediated signaling have been implicated with the pathophysiology of various neuropsychiatric conditions. Bipolar disorder (BD) is a mental disorder, characterized by alterning between manic/hypomanic and depressive mood. In experimental research, the pharmacological inhibition of DA reuptake using GBR 12909 serves as a tool to elicit BD-like phenotypes. Alternative model organisms, such as the zebrafish (<em>Danio rerio</em>), have been considered important systems for investigating the neurobehavioral changes involved in different neuropsychiatric conditions, including BD. Here, we discuss the use of GBR 12909 as a novel pharmacological strategy to mimic BD-like phenotypes in zebrafish models. We also emphasize the well-conserved DA-mediated signaling in zebrafish and the early expression of dopaminergic biomarkers in the brain, especially focusing on dopamine transporter (DAT), the main target of GBR 12909. Finally, we discuss potential advantages and limitations in the field, the perspectives of using GBR 12909 in BD research, and how distinct validation criteria (<em>i.e.</em>, face, predictive, and construct validity) can be assessed in translational approaches using zebrafish-based models.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115302"},"PeriodicalIF":2.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between Scylla and Charybdis: Fixed-ratio avoidance response effort and unavoidable shock extinction in humans","authors":"Simon Dymond ,&nbsp;Weike Xia ,&nbsp;Daniel V. Zuj ,&nbsp;Martyn Quigley","doi":"10.1016/j.bbr.2024.115299","DOIUrl":"10.1016/j.bbr.2024.115299","url":null,"abstract":"<div><div>Avoidance of potential threat may become maladaptive when it is indiscriminate and resistant to change. Here, we investigated the resistance to change of high and low avoidance response effort when avoidance extinction involved unavoidable presentations of the aversive event (shock) in humans. Following fear conditioning, participants prevented upcoming shock delivery by responding on high (i.e., fixed ratio, FR-20) and low (FR-5) negative reinforcement schedules. Next, noneliminable shock was used for an avoidance extinction procedure whereby responding was followed by, rather than prevented, shock. During a subsequent standard extinction and response prevention test phase, we found that High effort (FR-20) avoidance would be more readily extinguished than Low effort (FR-5) avoidance. It was also predicted that fear, threat expectancy, and psychophysiological (skin conductance) responses would decrease on avoidable trials and increase on unavoidable trials before extinguishing to low levels. It was found that in the final extinction re-test phase when avoidance was possible, responding increased, particularly for low effort cues. Both fear and expectancy remained high. Individual differences on clinically relevant measures of trait anxiety, intolerance of uncertainty and experiential avoidance were associated with greater levels of fear and threat expectancy. Overall, unavoidable shock extinction may hold promise for further translational investigations of avoidance learning, extinction, and clinical treatment development.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115299"},"PeriodicalIF":2.6,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of the serotonergic, GABAergic and glutamatergic systems of the rostral anterior cingulate cortex in the trait and state anxiety of adult male Wistar rats.","authors":"Thiago Henrique Almeida-Souza ,&nbsp;Rodolfo Santos Silva ,&nbsp;Heitor Santos Franco ,&nbsp;Leandra Martins Santos ,&nbsp;João Eduardo Conceição Melo ,&nbsp;Ana Mara de Oliveira e Silva ,&nbsp;Edênia Cunha de Menezes ,&nbsp;José Ronaldo dos Santos ,&nbsp;Flavia Teixeira-Silva ,&nbsp;Tiago Costa Goes ,&nbsp;Murilo Marchioro","doi":"10.1016/j.bbr.2024.115298","DOIUrl":"10.1016/j.bbr.2024.115298","url":null,"abstract":"<div><div>Despite significant advancements to understand of the neural circuitry involved in anxiety, the neurobiology of trait anxiety remains unclear. The rostral anterior cingulate cortex (rACC) and various pathways have been implicated in its regulation, making it a key to trait anxiety. The present study aimed to investigate the role of these neurotransmitter systems in the rACC in trait anxiety. Since trait anxiety is known to modulate state anxiety, we further investigated this relationship. Specifically, in Experiment I, we used animals with high trait anxiety; in Experiment II, we used animals with low trait anxiety; and in Experiment III, we used animals with medium trait anxiety. Before each behavioral assessment, drugs that either increased or decreased serotonergic (Fluoxetine or WAY-100635), GABAergic (Muscimol or Bicuculline), and glutamatergic (NMDA or Ketamine) neurotransmission in the rACC were administered, along with their respective controls. Additionally, in Experiment IV, all animals from the previous experiments were subjected to the Elevated Plus Maze (EPM) and Hole board (HB) test and evaluated without taking into account their trait anxiety levels. The results of the present study showed that, in Exp I, the modulation of the serotonergic, GABAergic and glutamatergic systems in the rACC decreased trait anxiety in highly anxious rats, while by submitting the animals to HB, the administration of fluoxetine increased state anxiety. In Exp II, the modulation of all systems increased trait anxiety in rats with low trait anxiety, whereas, in HB, state anxiety levels were increased with the administration of NMDA. In Exp III, only the modulation of the glutamatergic system, with NMDA, increased both trait and state anxiety levels. However, none of the evaluated neurotransmitter systems altered the state anxiety modeled in the EPM. Overall, the results of the present study provide new insights into the role of the neurotransmitter systems in the rACC in the regulation of trait anxiety and state anxiety.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115298"},"PeriodicalIF":2.6,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}