Behavioural Brain Research最新文献

{"title":"The effects of moderate prenatal alcohol exposure on performance in object and spatial discrimination tasks by adult male rats","authors":"Lilliana M. Sanchez ,&nbsp;Gabriela Acosta ,&nbsp;Sarah D. Cushing ,&nbsp;Sarah A. Johnson ,&nbsp;Sean M. Turner ,&nbsp;Suzy Davies ,&nbsp;Daniel D. Savage ,&nbsp;Sara N. Burke ,&nbsp;Benjamin J. Clark","doi":"10.1016/j.bbr.2024.115324","DOIUrl":"10.1016/j.bbr.2024.115324","url":null,"abstract":"<div><div>Exposure to alcohol during pregnancy produces Fetal Alcohol Spectrum Disorders, which in its most severe form is characterized by physical dysmorphology and neurobehavioral alterations. Moderate prenatal alcohol exposure (mPAE) is known to produce deficits in discrimination of spatial locations in adulthood. However, the impact of mPAE on higher-order sensory representations, such as discrimination of perceptually similar stimuli, is currently unknown. In the present study, we tested the hypothesis that mPAE would disrupt performance on hippocampal-sensitive tasks that require discrimination between perceptually similar objects or discrimination between spatial locations in a radial arm maze. Here we report that male mPAE rats exhibited intact performance on three types of object discrimination tasks: one in which rats discriminated between distinct toy objects, a second in which discrimination was made between distinct and similar LEGO objects, and a mnemonic similarity task in which rats discriminated between randomly presented LEGO objects that varied in similarity with a learned object. Although adult male mPAE rats performed similarly to control rats on all three object discrimination tasks, they showed deficits when tested in a radial arm maze spatial discrimination task. Specifically, male mPAE rats expressed a significantly higher number of working memory errors (returns to previously visited arms) and were more likely to use non-spatial strategies during training. Together, the findings of the present study support the conclusion that mPAE produces specific deficits in the online processing of spatial information and executing spatial navigation strategies, but spares the ability to discriminate between perceptually similar stimuli.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"478 ","pages":"Article 115324"},"PeriodicalIF":2.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academic-related stressors predict depressive symptoms in graduate students: A machine learning study","authors":"Aline F. Bastos ,&nbsp;Orlando Fernandes-Jr ,&nbsp;Suzana P. Liberal ,&nbsp;Anna Júlia L. Pires ,&nbsp;Luisa A. Lage ,&nbsp;Olga Grichtchouk ,&nbsp;Aline R. Cardoso ,&nbsp;Leticia de Oliveira ,&nbsp;Mirtes G. Pereira ,&nbsp;Giovanni M. Lovisi ,&nbsp;Raquel B. De Boni ,&nbsp;Eliane Volchan ,&nbsp;Fatima S. Erthal","doi":"10.1016/j.bbr.2024.115328","DOIUrl":"10.1016/j.bbr.2024.115328","url":null,"abstract":"<div><h3>Background</h3><div>Graduate students face higher depression rates worldwide, which were further exacerbated during the COVID-19 pandemic. This study employed a machine learning approach to predict depressive symptoms using academic-related stressors.</div></div><div><h3>Methods</h3><div>We surveyed students across four graduate programs at a Federal University in Brazil between October 15, 2021, and March 26, 2022, when most activities were restricted to taking place online due to the pandemic. Through an online self-reported screening, participants rated ten academic stressors and completed the Patient Health Questionnaire (PHQ-9). Machine learning analysis tested whether the stressors would predict depressive symptoms. Gender, age, and race and ethnicity were used as covariates in the predictive model.</div></div><div><h3>Results</h3><div>Participants (n=172), 67.4 % women, mean age: 28.0 (SD: 4.53) fully completed the online questionnaires. The machine learning approach, employing an epsilon-insensitive support vector regression (Ɛ-SVR) with a k-fold (k=5) cross-validation strategy, effectively predicted depressive symptoms (r=0.51; R²=0.26; NMSE=0.79; all p=0.001). Among the academic stressors, those that made the greatest contribution to the predictive model were “fear and worry about academic performance”, “financial difficulties”, “fear and worry about academic progress and plans”, and “fear and worry about academic deadlines”.</div></div><div><h3>Conclusions</h3><div>This study highlights the vulnerability of graduate students to depressive symptoms caused by academic-related stressors during the COVID-19 pandemic through an artificial intelligence methodology. These findings have the potential to guide policy development to create intervention programs and public health initiatives targeted towards graduate students.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"478 ","pages":"Article 115328"},"PeriodicalIF":2.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of forced and voluntary exercise types on male rat brain monoamine levels, anxiety-like behaviour, and physiological indexes under light and dark phases","authors":"Daisuke Matsunaga ,&nbsp;Hikaru Nakagawa ,&nbsp;Takayuki Ishiwata","doi":"10.1016/j.bbr.2024.115321","DOIUrl":"10.1016/j.bbr.2024.115321","url":null,"abstract":"<div><h3>Purpose</h3><div>Physical exercise improves physical and mental health; however, the differences between voluntary and forced exercise protocols are unclear. In addition, knowledge regarding the consequences of differences in testing timing, such as light and dark phases, in response to exercise type is limited. We investigated the effects of chronic forced and voluntary wheel running on the changes in brain monoamine levels (5-HT: serotonin, DA: dopamine, NA: noradrenaline), anxiety-like behaviours, and physiological stress responses in the light and dark phases.</div></div><div><h3>Methods</h3><div>Adult male Wistar rats were equally and randomly assigned to four groups: sedentary control, voluntary exercise (free running on a wheel, V-EX), voluntary limited exercise (wheel available only 1 h/day, VL-EX), and forced exercise (running on a motorised wheel, F-EX). Each group was further divided into dark- or light-experimental condition groups. After 4 weeks, the rats underwent an open-field test. The monoamines and their metabolite levels were measured in the major neural cell bodies and the projection areas related to behaviour, cognition, anxiety, and stress in the brain.</div></div><div><h3>Results</h3><div>Adrenal hypertrophy and elevated body temperature, except during the exercise period, were observed in the F-EX rats that exhibited anxiety-like behaviour. The levels of monoamines and their metabolites, particularly the 5-HTergic and DAergic systems, in specific areas, were significantly altered in the rats in the V-EX group compared to those in the VL-EX and other groups. These differences were observed only in the dark phase.</div></div><div><h3>Conclusion</h3><div>The results suggest that V-EX mainly stimulates the 5-HTergic and DAergic systems, while F-EX induces physiological stress and increases anxiety-like behaviour during the dark phase. This study highlights the importance of accounting for exercise types and light/dark phases in behavioural neuroscience experiments.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"479 ","pages":"Article 115321"},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression diagnosis: EEG-based cognitive biomarkers and machine learning","authors":"Kiran Boby,&nbsp;Sridevi Veerasingam","doi":"10.1016/j.bbr.2024.115325","DOIUrl":"10.1016/j.bbr.2024.115325","url":null,"abstract":"<div><div>Depression is a complex mental illness that has significant effects on people as well as society. The traditional techniques for the diagnosis of depression, along with the potential of nascent biomarkers especially EEG-based biomarkers, are studied. This review explores the significance of cognitive biomarkers, offering a comprehensive understanding of their role in the overall assessment of depression. It also investigates the effects of depression on various brain regions, outlines promising areas for future research, and emphasizes the importance of understanding the neurophysiological roots of depression. Furthermore, it elucidates how machine learning and deep learning models are integrated into EEG-based depression diagnosis, emphasizing their importance in optimizing personalized therapeutic protocols and improving diagnostic accuracy with EEG data analysis.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"478 ","pages":"Article 115325"},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower DTI-ALPS index in patients with major depressive disorder: Correlation with fatigue","authors":"Wenxin Bao ,&nbsp;Ping Jiang ,&nbsp;Peiwei Xu ,&nbsp;Hai Lin ,&nbsp;Jiaqi Xu ,&nbsp;Mingfeng Lai ,&nbsp;Jianmin Yuan ,&nbsp;Jiajun Xu","doi":"10.1016/j.bbr.2024.115323","DOIUrl":"10.1016/j.bbr.2024.115323","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is an index that may provide insights into intracranial waste clearance processes. Glymphatic system dysfunction has been suggested to play a role in the development of major depressive disorder (MDD). Additionally, fatigue—a common precursor of MDD—is also closely connected to the waste clearance function of the central nervous system (CNS), further underscoring the significance of efficient waste removal in MDD. However, evidence linking altered DTI-ALPS index to MDD remains limited. This study aims to investigate the changes in the DTI-ALPS index in patients with MDD and explore the potential interplay between DTI-ALPS index alterations, fatigue, and the presence of MDD.</div></div><div><h3>Material and methods</h3><div>A total of 46 patients with MDD and 55 healthy controls (HC) were included in the study. All participants underwent diffusion tensor imaging using the same 3-T MRI (3-Tesla Magnetic Resonance Imaging) scanner. The DTI-ALPS index was assessed, and the Chalder Fatigue Scale (CFS) was used to evaluate fatigue levels in both groups, and the 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate the severity of depression in the patients. We compared the DTI-ALPS index and clinical characteristics between the MDD and HC group, and explored the relationship among the DTI-ALPS index, CFS scores, and the presence of MDD through mediation analysis.</div></div><div><h3>Results</h3><div>The DTI-ALPS index in the right hemisphere (DTI-ALPS-R) is significantly lower in patients with MDD (t = 2.41, <em>P</em> = 0.02). The MDD patients exhibited significantly higher scores on the CFS scales compared with HCs (t = 13.12, <em>P</em> &lt;.001). Mediation analysis showed that the CFS score plays a significant mediating role between DTI-ALPS-R and the presence of MDD, acting as a full mediator (indirect effect <em>β</em> = −0.230, 95 % CI: [-0.388, −0.059]).</div></div><div><h3>Conclusion</h3><div>Our study found that patients with MDD have a reduced DTI-ALPS index. This reduction appears to contribute to the development of MDD by facilitating the accumulation of fatigue symptoms. These findings may provide a new perspective on the pathogenesis of MDD, suggest a potential new biomarker for MDD, and offer new insights for its treatment.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"478 ","pages":"Article 115323"},"PeriodicalIF":2.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional (3D) stimuli are always better than two-dimensional (2D) multi-tasking? A high cognitive load in 3D-MATB-II","authors":"Xiang Che ,&nbsp;Ruiyi Tang ,&nbsp;Jingkang Lin ,&nbsp;Qi Hui ,&nbsp;Yu Zhang ,&nbsp;Jie Li ,&nbsp;Jijun Lan","doi":"10.1016/j.bbr.2024.115322","DOIUrl":"10.1016/j.bbr.2024.115322","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to investigate the whether multi-tasking performance in (three-dimensional) 3D aid or impede cognition compare to (two-dimensional) 2D environments, as reflected by cognitive load. Specifically, we aim to examine the mechanism of multi-tasking under 3D (virtual reality [VR]) and 2D (PC monitor) conditions using the widely used Multi-Attribute Task Battery (MATB) II paradigm.</div></div><div><h3>Methodology</h3><div>The MATB-II sub-tasks, namely “Tracking” and “System Monitoring,” were conducted with varying task demands in both 3D conditions (Tracking Far - System Monitoring Near [TF-SN], Tracking Near - System Monitoring Far [TN-SF]) and a 2D condition with no depth perception (No Depth [ND]). Participants' cognitive load was assessed using subjective reporting (NASA-TLX) and physiological measure (root mean square of successive difference (RMSSD) of heart rate variability (HRV)).</div></div><div><h3>Results</h3><div>The study found that performance was significantly better in the ND condition compared to the TF-SN and TN-SF conditions. Furthermore, higher NASA-TLX scores and lower RMSSD values were observed in the TF-SN and TN-SN conditions compared to the ND condition, providing additional support for the overall findings of the MATB-II paradigm.</div></div><div><h3>Conclusion</h3><div>These findings suggest that processing multiple tasks in different depth planes may lead to poorer performance and increased subjective and physiological cognitive load.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115322"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palatable feeding effects on expression and reinstatement of morphine conditioned place preference in male and female rats","authors":"Yonca Cam,&nbsp;Courtney G. Kocum,&nbsp;Tabitha K. Houska,&nbsp;Ella R. Konrad,&nbsp;Tim A. Schweizer,&nbsp;Matthew J. Will","doi":"10.1016/j.bbr.2024.115320","DOIUrl":"10.1016/j.bbr.2024.115320","url":null,"abstract":"<div><div>While many environmental factors are known to play a factor in the recovery and risk of relapse for individuals with opioid use disorder (OUD), the role of diet has been relatively unexplored. Individuals with OUD demonstrate unhealthy diet choices with an exaggerated craving for palatable “junk food,” yet this relationship has not been well characterized. The present study begins to examine this relationship by first determining the influence of palatable food access on the expression of conditioned rewarding properties of acute morphine exposure in male and female rats. Following the establishment of morphine conditioned place preference (CPP) in all rats, morphine CPP expression was assessed following intra-accumbens (Acb) administration of the µ-opioid receptor agonist D-Ala2,NMe-Phe4,Glyol5-enkephalin (DAMGO) + 20 min access to no diet (ND) or high-fat (HF), in counter-balanced order. Next, all rats received 12 sessions of extinction training before CPP expression was first assessed following no treatment, then again following counter-balanced ND and HF treatments. The results showed that both male and female rats expressed similar levels of morphine CPP. Subsequent examination of morphine CPP expression revealed that HF treatment significantly reduced morphine CPP expression in males, but not females, compared to ND treatment. Neither HF or ND treatment produced morphine CPP reinstatement in either males or females following extinction. In summary, the impact of palatable feeding on the expression of conditioned drug seeking may be sex-specific and more sensitive prior to extinction.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115320"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moringa oleifera Lam. seed lectin (WSMoL) reduces chronic stress-induced anxiety and depression in mice by lessening inflammation and balancing brain chemicals","authors":"Leydianne Leite de Siqueira Patriota ,&nbsp;Bárbara Raíssa Ferreira de Lima ,&nbsp;Amanda de Oliveira Marinho ,&nbsp;Jainaldo Alves da Costa ,&nbsp;Alex Leandro Andrade de Lucena ,&nbsp;Patrícia Maria Guedes Paiva ,&nbsp;Daniella Carla Napoleão ,&nbsp;Jorge Vinícius Fernandes Lima Cavalcanti ,&nbsp;Michelly Cristiny Pereira ,&nbsp;Thiago Henrique Napoleão ,&nbsp;Michelle Melgarejo da Rosa","doi":"10.1016/j.bbr.2024.115318","DOIUrl":"10.1016/j.bbr.2024.115318","url":null,"abstract":"<div><div>Phyto-based treatments for anxiety and depression are gaining attention. The efficacy of the water-soluble <em>Moringa oleifera</em> seed lectin (WSMoL) in reducing acute anxiolytic and depressive-like behaviors in mice has been previously demonstrated. In the present study, it was evaluated the effects of WSMoL on reducing anxiety and depressive-like symptoms in a mouse model of unpredictable chronic mild stress (UCMS). The animals were divided into groups and exposed to a four-week UCMS regimen. Following this, the mice received daily intraperitoneal injections of vehicle (non-stressed and UCMS control groups), WSMoL (2 or 4 mg/kg), or fluoxetine (10 mg/kg) for 21 days. Neurobehavioral tests included the open field test and elevated plus maze test to assess anxiety-like behavior, and the tail suspension test and sucrose preference test to evaluate depression-like behavior. Biochemical analyses measured serum corticosterone and cytokines as well brain levels of cytokines and monoamines. All tests indicated that WSMoL significantly (p &lt; 0.05) reversed the anxiety and depression-like behaviors induced by UCMS. The stress protocol increased serum corticosterone levels and WSMoL treatment was not able to normalize corticosterone secretion. WSMoL treatment reduced serum and brain levels of IL-2, IL-6, and TNF-α, indicating reduced neuroinflammation, and increased brain levels of dopamine, serotonin, and noradrenaline. In summary, WSMoL mitigated UCMS-induced anxiety and depression-like behaviors by reducing neuroinflammation and modulating brain monoamine levels.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115318"},"PeriodicalIF":2.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Similarities and differences between chronic primary pain and depression in brain activities: Evidence from resting-state microstates and auditory Oddball task","authors":"Lele You ,&nbsp;Banghua Yang ,&nbsp;Xi Lu ,&nbsp;Aolei Yang ,&nbsp;Yonghuai Zhang ,&nbsp;Xiaoying Bi ,&nbsp;Shu Zhou","doi":"10.1016/j.bbr.2024.115319","DOIUrl":"10.1016/j.bbr.2024.115319","url":null,"abstract":"<div><h3>Background</h3><div>In 2019, the International Association for the Study of Pain introduced the concept of 'chronic primary pain (CPP)', characterized by persistent non-organic pain with emotional and functional abnormalities. Underdiagnosed and linked to depression, CPP has poorly understood neural characteristics. Electroencephalogram (EEG) microstates enable detailed examination of brain network dynamics at the millisecond level. Incorporating task-related EEG features offers a comprehensive neurophysiological signature of brain dysfunction, facilitating exploration of potential neural mechanisms.</div></div><div><h3>Methods</h3><div>This study employed resting-state and task-related auditory Oddball EEG paradigm to evaluate 20 healthy controls, 20 patients with depression, and 20 patients with CPP. An 8-minute recording of resting-state EEG was conducted to identify four typical microstates (A-D). Additionally, power spectral density (PSD) features were examined during an auditory Oddball paradigm.</div></div><div><h3>Results</h3><div>Both CPP and Major Depressive Disorder (MDD) patients exhibited reduced occurrence rate and transition probabilities of other microstates to microstate C during resting-state EEG. Furthermore, more pronounced increase in Gamma PSD was observed in the occipital region of CPP during the Oddball task. In CPP, both resting-state microstate C and task-related Gamma PSD correlated with pain and emotional indicators. Notably, microstate C occurrence positively correlated with occipital Gamma PSD in MDD.</div></div><div><h3>Conclusion</h3><div>Conclusively, both CPP and MDD display dynamic abnormalities within the salient network, closely associated with pain and depressive symptoms in CPP. Unlike MDD, CPPs' dynamic network changes appear unrelated to perceptual integration function, indicating differing microstate functional impacts. Combining resting-state microstates and Oddball tasks may offer a promising avenue for identifying potential biomarkers in objectively assessing chronic primary pain.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115319"},"PeriodicalIF":2.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LF-DBS of the ventral striatum shortens persistence for morphine place preference and modulates BDNF expression in the hippocampus","authors":"Mario E. Lloret-Torres,&nbsp;Jennifer L. Barreto-Estrada","doi":"10.1016/j.bbr.2024.115300","DOIUrl":"10.1016/j.bbr.2024.115300","url":null,"abstract":"<div><h3>Background</h3><div>Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) represents a promising therapy for treatment-refractory patients with substance-use disorders. We previously found that low-frequency (LF) DBS aimed to the VC/VS during extinction training strengthens the extinction memory for morphine seeking under a partial extinction protocol.</div></div><div><h3>Objectives/Hypothesis</h3><div>In this study, animals were tested in a full extinction protocol to determine whether LF-DBS applied during extinction facilitates extinction while preventing drug reinstatement, and study the molecular mechanisms underlying the effects of LF-DBS,</div></div><div><h3>Methods/Results</h3><div>We used a full extinction CPP paradigm combined with LF-DBS to assess behavior. Western blots for the pro-extinction molecule, brain-derived neurotrophic factor (BDNF) were then performed in corticomesolimbic regions of the brain. Lastly, to determine whether changes in BDNF expression elicited by LF-DBS were specific to the VS/NAc afferents from the hippocampus, amygdala, and medial prefrontal cortex, we performed BDNF-like immunohistochemistry, combined with the retrograde tracer cholera toxin <em>B</em> (Ct<em>B</em>).</div></div><div><h3>Results</h3><div>We showed a significant reduction in the number of days required to fully extinguish morphine CPP in animals exposed to LF-DBS during extinction training accompanied by a significant increase in BDNF expression in the hippocampus. However, LF-DBS applied during extinction did not prevent drug reinstatement. Lastly, no changes in BDNF/Ct<em>B</em> double-labeled cells were found in VS/NAc projecting cells after one-day exposure to LF-DBS.</div></div><div><h3>Conclusion(s)</h3><div>These data suggest that LF-DBS can facilitate extinction of morphine CPP by decreasing drug seeking through potential synaptic plasticity changes in the hippocampus to strengthen extinction memories.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"477 ","pages":"Article 115300"},"PeriodicalIF":2.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}