Behavioural Brain Research最新文献

{"title":"Overexpression of S100B promotes depressive-like behaviors in stroke-induced rats by modulating the PI3K/AKT/NF-κB pathway","authors":"Hao Lei ,&nbsp;Fuping Zhang ,&nbsp;Mengyang Tao ,&nbsp;Jiqing Lang ,&nbsp;Yanjiao Pei ,&nbsp;Huanhuan Liu ,&nbsp;Zhaohui Zhang ,&nbsp;Jinggui Song","doi":"10.1016/j.bbr.2025.115597","DOIUrl":"10.1016/j.bbr.2025.115597","url":null,"abstract":"<div><div>Post-stroke depression (PSD) is a common complication following a stroke, primarily characterized by low mood, cognitive sluggishness, and sleep disturbances. Currently, the precise pathogenic mechanisms underlying PSD remain elusive. Research indicates that S100B protein levels may serve as a specific biochemical marker of organic brain injury, with significantly elevated serum S100B levels noted in patients with ischemic stroke, depression, and schizophrenia. S100B facilitates apoptosis through various cellular signaling pathways and is implicated in inflammatory responses, thereby participating in the pathophysiology of numerous diseases. Nonetheless, the role of elevated S100B expression in PSD remains unclear. This study used a PSD rat model created by combining MCAO and CUMS to evaluate depressive behaviors. The expression of S100B and proteins associated with the PI3K/AKT/NF-κB signaling pathway was analyzed, while changes in inflammatory factors such as IL-1, IL-6, and TNF-α were quantified using ELISA. The findings demonstrated that the combination of MCAO and CUMS effectively induced depressive-like behaviors in the rats. In the PSD rat model, overexpression of S100B may inhibit the PI3K/AKT pathway and activate the NF-κB signaling pathway, thereby promoting the expression of inflammatory factors such as IL-1, IL-6, and TNF-α, which exacerbate brain tissue damage. However, the administration of S100B inhibitors improved depressive-like behaviors in PSD rats and reversed the alterations in the aforementioned signaling pathways and inflammatory factors. These findings advance the understanding of PSD pathogenesis and suggest therapeutic strategies.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"488 ","pages":"Article 115597"},"PeriodicalIF":2.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome modulation as a novel therapeutic modality for anxiety disorders: A review of clinical trials","authors":"Emre Adıgüzel,&nbsp;Şemsi Gül Yılmaz,&nbsp;Büşra Atabilen,&nbsp;Betül Şeref","doi":"10.1016/j.bbr.2025.115595","DOIUrl":"10.1016/j.bbr.2025.115595","url":null,"abstract":"<div><div>Anxiety disorders are one of the major conditions in psychiatry characterized by symptoms such as worry, social and performance fears, unexpected and/or triggered panic attacks, anticipatory anxiety, and avoidance behaviors. Recent developments have drawn attention to the putative involvement of peripheral systems in the control of anxiety, and the gut microbiota has come to light as an emerging peripheral target for anxiety. The relationship between the gut-brain axis, a bidirectional communication network between the central nervous system (CNS) and enteric nervous system (ENS), and anxiety has been the subject of some recent studies. Therefore, this systematic review analyzed clinical trials evaluating the potential of microbiome modulation methods in mitigating and ameliorating anxiety disorders. Clinical studies on probiotic, prebiotic, synbiotic supplements, dietary interventions, and fecal microbiota transplantation in anxiety disorders were screened. All of the studies examined the effects of probiotic intervention. One of these studies compared a prebiotic-rich diet with probiotic supplementation. Longitudinal analyses showed that the probiotic intervention alleviated anxiety. However, most of the controlled studies reported that the probiotic intervention did not make a difference compared to placebo. Thus, the current findings suggest that it is too early to consider the promising role of microbiome modulation in the treatment of anxiety disorders. However, it is obvious that more clinical research is needed to clarify issues such as probiotic strains, prebiotic types, and their doses that may be effective on anxiety disorders.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115595"},"PeriodicalIF":2.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered hypothalamic functional connectivity after partial sleep deprivation in young and elderly adults","authors":"Jing Qi,&nbsp;Wen-Li Hu","doi":"10.1016/j.bbr.2025.115587","DOIUrl":"10.1016/j.bbr.2025.115587","url":null,"abstract":"<div><h3>Background</h3><div>The hypothalamus plays a critical role in sleep-wake regulation and attention control. However, few studies explored the alterations of hypothalamic functional connectivity after sleep deprivation. The purpose of the study is to investigate the influence of partial sleep deprivation on hypothalamic functional connectivity in young and elderly adults and to determine whether age modulates the interactions between partial sleep deprivation and hypothalamic functional connectivity.</div></div><div><h3>Methods</h3><div>Data for this study were collected as part of the Stockholm Sleepy Brain Project. Forty-one young adults (aged 20–30) and thirty-six elderly adults (aged 65–75) were finally recruited in the study. Participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans following full sleep and partial sleep deprivation (3 h of sleep) in a crossover design. Seed-based functional connectivity analyses were performed for the bilateral hypothalamus using rs-fMRI data.</div></div><div><h3>Results</h3><div>For young adults, partial sleep deprivation caused enhanced hypothalamic functional connectivity with the inferior frontal gyrus and precuneus. For elderly adults, reduced functional connectivity was observed between the hypothalamus and frontal, parietal, temporal, occipital regions, and cingulate gyrus following partial sleep deprivation. Further, a significant interactive effect between age and partial sleep deprivation on the hypothalamic functional connectivity was observed. Age-related abnormalities of hypothalamic functional connectivity were observed in frontoparietal regions, pallidum, rectus, and superior occipital gyrus.</div></div><div><h3>Conclusion</h3><div>Partial sleep deprivation led to increased hypothalamic functional connectivity in young adults, while decreased hypothalamic functional connectivity in elderly adults. Our results indicate that age modulates the influence of sleep deprivation on intrinsic brain functional connectivity.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"488 ","pages":"Article 115587"},"PeriodicalIF":2.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population dependent rearing modifies sleep and decision-making ability with the involvement of noradrenaline: A study conducted using zebrafish as a model","authors":"Kumar Abhishek ,&nbsp;Birendra Nath Mallick","doi":"10.1016/j.bbr.2025.115573","DOIUrl":"10.1016/j.bbr.2025.115573","url":null,"abstract":"<div><div>Sleep is an instinct phenomenon, which affects cognitive processes including learning, memory and decision-making. Its quality, quantity and pattern vary in species through evolution. Living in groups (compared to living individually) with an increased population (as a family and a society) is an important contributing factor influencing the evolution of many behaviours. We hypothesized that rearing (upbringing) among many individuals (as compared to in isolation) and socialization might have influenced the quality, quantity and pattern of optimum sleep (a fundamental behaviour), which in turn affected animal behaviour(s) including learning and decision-making. To confirm, using zebrafish (which expresses shoaling) as a model we evaluated their sleep pattern as well as decision-making ability when reared post-birth under isolated (individually) or populated conditions. We observed that zebrafish reared under isolation affected sleep and compromised their decision-making ability when exposed to predator, which otherwise threatens their survivability. Also, the adverse effects of isolation were improved when the zebrafish were either reared in shoal or, by α1-adrenoceptor antagonist, prazosin, suggesting the role of noradrenaline in mediating the responses. Based on our findings we propose that one of the physiological benefits of living in a society is better (optimum) sleep health, which in turn helps with quality living.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115573"},"PeriodicalIF":2.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine alleviates maternal separation-induced schizophrenia-like behaviors by preventing autophagic degradation of TRPV1","authors":"Ying Xiong ,&nbsp;Shilin Xu ,&nbsp;Keke Hao ,&nbsp;Fashuai Chen ,&nbsp;Rui Xu ,&nbsp;Shijing Wang ,&nbsp;Huan Huang ,&nbsp;Zhongchun Liu ,&nbsp;Gaohua Wang ,&nbsp;Huiling Wang","doi":"10.1016/j.bbr.2025.115579","DOIUrl":"10.1016/j.bbr.2025.115579","url":null,"abstract":"<div><div>Previous studies have shown that schizophrenia is closely related to transient receptor potential vanilloid1 (TRPV1). It is reported that downregulation of TRPV1 occurs in animals undergoing maternal separation (MS) which can induce behaviors and pathology reminiscent of schizophrenia. In vitro, cortisol was found to degrade TRPV1 via autophagy induction. Hydroxychloroquine (HCQ), an autophagy inhibitor, is recognized as an effective treatment to lower the risk of central nervous system degenerative diseases. This study aimed to explore whether HCQ can alleviate schizophrenia-like behaviors by modulating TRPV1 in a MS induced schizophrenia model. HCQ was administered at a dose of 2 mg/kg to rats just before MS on postnatal day 9 (PND9). Behavioral tests and measurements of biological markers were undertaken on PND10 and in adulthood. Furthermore, autophagy and TRPV1 levels were detected in the HT22 cells model. The results showed that autophagy levels increased in the hippocampus and prefrontal cortex of PND10 in MS rats, accompanied by decreased TRPV1. MS rats in adulthood showed impaired autophagy function and neuronal apoptosis in the hippocampus and prefrontal cortex, accompanied by schizophrenia-like behaviors. Early treatment with HCQ reverses these changes in MS rats and alleviates behavioral abnormalities. Our findings in the HT22 cells model confirmed the link between TRPV1 and autophagy. In summary, our findings suggest that HCQ prevents TRPV1 degradation via autophagy, alleviating MS-induced neurobiological and behavioral alterations.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115579"},"PeriodicalIF":2.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and sex independently influence safety learning in mice","authors":"Gabrielle Magalhães ,&nbsp;Beckett Blocker ,&nbsp;Hannah Burnell ,&nbsp;Sambridhi Subedi ,&nbsp;Heidi Meyer","doi":"10.1016/j.bbr.2025.115594","DOIUrl":"10.1016/j.bbr.2025.115594","url":null,"abstract":"<div><div>Difficulty discriminating between threat and safety cues is a hallmark symptom of many fear-related disorders including anxiety, which are highly prevalent during adolescence. Moreover, females are disproportionately affected by fear and anxiety disorders. Correspondingly, growing evidence suggests that sex differences in fear responding and regulation are readily apparent in adults. Yet, it remains unclear when these differences emerge throughout development and what behavioral factors may drive them. Using adult (postnatal day/PND 69–128) and adolescent (PND 29–34) mice, we set out to study age and sex differences in learning about cues explicitly indicating safety (i.e., safety learning). Our results revealed that female mice of both ages froze more and discriminated less than males of both ages during initial discriminative conditioning. All mice showed evidence of conditioned inhibition during a summation test, though the magnitude of suppression was smaller in females. During an expanded summation test that included novel cues and different combinations of stimulus parameters, females of both ages exhibited higher fear generalization to novel cues. In addition, adolescents of both sexes failed to inhibit fear using a safety cue, suggesting that adolescent learning may be disrupted by complex experimental design. Finally, neural activity (cFos expression) was greater in the prefrontal cortex and ventral hippocampus of adolescents relative to adults, and the retrosplenial cortex and ventral hippocampus of males relative to females. Together, these findings illustrate the potential to take age and sex into account in the identification and treatment of fear and anxiety disorders.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115594"},"PeriodicalIF":2.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The time-dependent effects of physical exercise on fear memory reconsolidation and extinction in male rats","authors":"Vitor Flores Ferreira ,&nbsp;Rossana Rosa Porto ,&nbsp;Bruno Popik ,&nbsp;Angel David Arellano Pérez ,&nbsp;Henrique Schaan Fernandes ,&nbsp;Débora Aguirre Gonçalves ,&nbsp;Lucas de Oliveira Alvares","doi":"10.1016/j.bbr.2025.115593","DOIUrl":"10.1016/j.bbr.2025.115593","url":null,"abstract":"<div><div>Aversive memories can enter a labile state during reactivation, allowing its content to be modified. Molecular changes induced by distinct interventions such as physical exercise can either facilitate or impair the strength of the original memory. However, the effect of the physical exercise performed at distinct time-points around memory reactivation remains poorly understood. Here we investigated how a single treadmill exercise bout delivered at different moments before or after a 5, 15 or 30-min reactivation session influences the reconsolidation and extinction of contextual fear conditioned memory in rats. Our results indicate that physical exercise of low-intensity 24 h and 10 min before the reactivation impairs reconsolidation and facilitates extinction. However, when the exercise protocol is performed immediately after the reactivation session, it facilitates reconsolidation and impairs extinction memory. Our results suggest that the specific time-point in which the physical exercise is performed plays an essential role in the reconsolidation and extinction outcome in fear conditioned animals.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115593"},"PeriodicalIF":2.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep deprivation and memory consolidation in rats: A meta-analysis of experimental studies","authors":"Cristina Dumitru ,&nbsp;Claudia Iuliana Iacob ,&nbsp;Florin Zamfirache ,&nbsp;Ruxandra Folostina ,&nbsp;Beatrice Mihaela Radu","doi":"10.1016/j.bbr.2025.115591","DOIUrl":"10.1016/j.bbr.2025.115591","url":null,"abstract":"<div><div>Sleep deprivation (SD) continues to be used today to examine the role of sleep across diverse cognitive domains. Extensive research has been conducted to investigate the impact of SD on memory, though findings across studies have been inconsistent. This meta-analysis systematically assessed the effects of SD on memory performance in rats and identified the factors that may moderate these effects. PubMed, PsychInfo, Google scholar, and Scopus databases were used to search for studies. Out of 128 identified studies, 25 studies with 78 reports were included in the final analysis. A random effects meta-analysis was performed, along with subgroup analysis and meta-regression. The results showed that overall, SD has a negative impact on memory in rats. Additionally, sex, memory response type, and number of learning trials for spatial tasks can act as moderators of the relationship between SD and memory. The type of memory task and assessment method used contributed to variability in observed outcomes, with hippocampus-dependent tasks showing the most pronounced memory impairments. The number of learning trials for spatial tasks also moderated the effects, with more trials mitigating the impact of SD. These findings reinforce the role of sleep in memory, particularly for hippocampus-dependent tasks.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115591"},"PeriodicalIF":2.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the neurophysiological basis of misinformation: A behavioral and neural complexity analysis","authors":"R. Molina ,&nbsp;Y. Crespo ,&nbsp;J.R. Árbol ,&nbsp;A.V. Arias-Orduña ,&nbsp;A.J. Ibáñez-Molina ,&nbsp;S. Iglesias-Parro","doi":"10.1016/j.bbr.2025.115592","DOIUrl":"10.1016/j.bbr.2025.115592","url":null,"abstract":"<div><div>The proliferation of misinformation on social media platforms poses significant challenges to public health, political discourse, and social cohesion. This study investigates the efficacy of a World Health Organization (WHO) infodemic intervention in mitigating the spread of misinformation and explores the underlying neural mechanisms involved in information processing. A sample of 77 university students was randomly assigned to an experimental group, which was exposed to the WHO's infodemic intervention, or a control group, which received a campaign on healthy lifestyle habits. Participants viewed a series of manipulated and non-manipulated tweets before and after the intervention, rating their likelihood to share, verify, and perceive the truthfulness of the information. Electroencephalogram (EEG) data were collected throughout the experiment to assess neural complexity using Sample Entropy (SampEn) measures. Results revealed that the experimental group significantly reduced their intention to share information and perceived truthfulness of both manipulated and non-manipulated items post-intervention. The control group showed no significant changes. EEG analysis demonstrated higher SampEn scores in the frontal and temporal regions for the experimental group post-intervention, indicating increased neural complexity and more homogeneous activation patterns. These findings suggest that the WHO intervention effectively enhanced participants' critical evaluation of information, reflected in both behavioral and neurophysiological changes. This study contributes to the growing body of research on misinformation interventions by providing evidence for the effectiveness of passive, less demanding campaigns in fostering critical thinking and information discernment. Moreover, it offers novel insights into the neural correlates of information processing following such interventions, highlighting the potential of combining behavioral and neurophysiological measures in misinformation research. These findings have important implications for developing targeted strategies to combat misinformation, enhance digital literacy, and inform future public health and policy initiatives in the digital era.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115592"},"PeriodicalIF":2.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of cognitive-motor interference in dual-task walking among healthy children aged 7–12 years","authors":"Delphine Fauvel,&nbsp;Olivier Daniel,&nbsp;Estelle Palluel","doi":"10.1016/j.bbr.2025.115577","DOIUrl":"10.1016/j.bbr.2025.115577","url":null,"abstract":"<div><div>This study investigated cognitive-motor interference (CMI) and attentional resource management during development using a dual-task (DT) paradigm. Participants aged 7–9 years (n = 11), 10–12 years (n = 14), and adults (n = 17) performed an auditory oddball task with two difficulty levels while sitting or walking on a treadmill. Cognitive and motor performance, along with P3a and P3b event-related potentials, were analyzed. Results showed improved cognitive and motor performance with age, associated with reorganization of brain responses. Children exhibited larger P3a and P3b amplitudes compared to adults, suggesting higher attentional resource allocation. Increasing cognitive difficulty led to decreased cognitive performance and increased P3a amplitude in children. Motor complexity resulted in decreased P3b amplitude in children, indicating reallocation of attentional resources to gait control. Notably, children aged 10–12 years demonstrated more adult-like CMI management strategies compared to younger children. The study revealed that attentional resource management evolves with age, with older children showing more efficient resource utilization despite similar resource allocation. These findings highlight the complex development of cognitive-motor systems and attentional resource management during childhood, emphasizing the importance of considering age-specific strategies in dual-task paradigms. The results contribute to understanding the developmental trajectory of CMI management and its implications for cognitive and motor performance in children.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"487 ","pages":"Article 115577"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}