Behavioural Brain Research最新文献

{"title":"An integrated approach to understanding the effects of exposome on neuroplasticity","authors":"Kirthana Kunikullaya U","doi":"10.1016/j.bbr.2025.115516","DOIUrl":"10.1016/j.bbr.2025.115516","url":null,"abstract":"<div><div>Anthropogenic factors are those that occur due to human activities. The exposome is proposed to complement the genome, wherein an individual’s exposure begins before birth. The range of exposures includes physical, chemical, dietary, lifestyle, biological, and occupational sources. Exposome has a positive or negative influence on neuroplasticity during different stages of life. A comprehensive study of the exposome is thus necessary to incorporate these factors and their influence on the individual, community, and the population as a whole. Exposomic research and global health present significant opportunities for interdisciplinary research. This review gives an overview of the exposome and its influence on neuroplasticity. It proposes methods to study the exposome on neuroplasticity across the lifespan of the individual. This is possible with the use of self-reported data, large-scale cohort formation, physiological sensors, neuroimaging, omics, molecular biology, and systems approaches. These approaches aim to provide a holistic understanding of an individual's neurological well-being and its implications for the population at large. This will also enable the designing of novel preventive and treatment strategies for managing neurological disorders.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"485 ","pages":"Article 115516"},"PeriodicalIF":2.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal α-Synuclein induces progressive behavioral impairments in mice","authors":"Yu-Ting Huang ,&nbsp;Tzu-Jung Yang ,&nbsp;Kou-Chen Liu ,&nbsp;Min-Chi Chen ,&nbsp;Pei-Ying S. Chan ,&nbsp;Jin-Chung Chen","doi":"10.1016/j.bbr.2025.115517","DOIUrl":"10.1016/j.bbr.2025.115517","url":null,"abstract":"<div><div>α-Synuclein (α-Syn) is implicated in the progression of Parkinson's disease, yet the disease's etiology remains unclear. This study aims to explore how α-Syn affects olfactory, motor, mood and cognitive functions if it initiates from the olfactory bulb. Mice were administered intranasal human AAV-α-Syn and subsequently evaluated for olfactory, motor, mood, and cognitive functions. Immunofluorescence was performed to assess dopaminergic neuronal damage. Results shown that olfactory dysfunction was evident as AAV-α-Syn-treated mice took longer to find buried pellets compared to controls at 3, 9, and 12 months post-instillation. Motor activity remained normal at 6 months but significantly declined at 9 months. Reduced tyrosine hydroxylase expression but increased amount of human α-Syn were observed in the substantia nigra at end of behavioral measurements. AAV-α-Syn mice showed reduced sucrose intake and decreased time in the center zone of the open field at 9 months. Cognitive deficits were observed in recognition function and social memory at 6 and 9 months, with impaired working memory at 12 months. Thus, intranasal AAV-α-Syn instillation in mice leads to progressive olfactory, motor, anxiety, depression-like, and cognitive dysfunctions, reflecting α-Syn pathology propagation.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"485 ","pages":"Article 115517"},"PeriodicalIF":2.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Prolyl endopeptidase as a novel anti-depression target of Genipin-1-b-D-gentiobioside in brain tissues","authors":"Yang Xiao ,&nbsp;Ling Gu ,&nbsp;Wenjing Zhang ,&nbsp;Yucui Jiang ,&nbsp;Cuihua Chen ,&nbsp;Weiwei Tao ,&nbsp;Feiyan Chen","doi":"10.1016/j.bbr.2025.115511","DOIUrl":"10.1016/j.bbr.2025.115511","url":null,"abstract":"<div><div>Depression is a serious mood disease that causes global impairment and mortality. In traditional Chinese medicine, herb compounds decoction with <em>Gardenia jasminoides</em> (GJ) as the main ingredient to treat depression has a history of hundreds of years in East Asian countries. Although the antidepressant effect of GJ has been well established, the antidepressant effect and target of its main component Genipin-1-b-D-gentiobioside (GG) remain unknown. In the present study, using a mouse chronic unpredictable mild stress (CUMS) model, we first examined the antidepressant effectiveness of GG. Next, we identified potential target proteins of GG in brain tissue using liquid chromatography-mass spectrometry (LC-MS)-based drug affinity responsive target stability (DARTS), and we intersected these targets with databases of depression targets to obtain GG's antidepressant protein targets. Finally, Prolyl endopeptidase (PREP) was initially confirmed as a potential antidepressant target of GG in brain tissue by molecular docking and biolayer interferometry (BLI). The results showed that GG administration reduced depression-like behavior in CUMS mice and increased the mRNA and protein expression levels of BDNF in the hippocampus of CUMS mice. Subsequently, there was an overlapping protein target between LC-MS-based DARTS and the databases of depression targets. Finally, molecular docking and BLI kinetic analysis indicated that GG specifically bound to PREP. According to the aforementioned research, PREP is a potential antidepressant protein target of GG in the brain. This conclusion could offer a chemical and biological foundation for future research on treating depression by focusing on PREP.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115511"},"PeriodicalIF":2.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscarinic cholinergic system of the dorsal hippocampus involvement in the modulation of formalin-induced orofacial nociception and relevant memory impairment in rats","authors":"Amir Erfanparast,&nbsp;Esmaeal Tamaddonfard,&nbsp;Sina Tamaddonfard,&nbsp;Behzad Firooznia,&nbsp;Ali Hatami-Marandi","doi":"10.1016/j.bbr.2025.115518","DOIUrl":"10.1016/j.bbr.2025.115518","url":null,"abstract":"<div><div>The hippocampus is well recognized for its significant contributions to learning, memory formation, and emotional regulation. In addition, it was approved by several studies that hippocampus plays a pivotal role in pain modulation; however, the exact mechanism has not yet been identified. In the current research, effects of microinjection of muscarinic M₁ cholinergic agents into the CA1 region of the hippocampus in orofacial nociception evoked by formalin and corresponding memory impairment were investigated. Left and right sides of the hippocampus were implanted by guide cannulas. Orofacial nociception was elicited through subcutaneously injection of formalin (1.5 %) solution into the pad of vibrissa region. Evaluating memory was conducted with Morris water maze (MWM). Microinjections of McN-A-343 (a selective agonist of muscarinic M₁ receptors) attenuated the both phases of orofacial nociceptive behavior, face rubbing. This effect of McN-A-343 was blocked by prior microinjection of pirenzepine (an antagonist of muscarinic receptors). On the other hand, McN-A-343 and pirenzepine increased and decreased traveled time as well as traveled distance in target zone of MWM, respectively. Additionally, McN-A-343 improved the memory deficits caused by orofacial nociception. Our results indicate that muscarinic acetylcholine receptors contribute significantly in the hippocampal modulation of orofacial nociception and related memory impairment.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115518"},"PeriodicalIF":2.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appetitive and aversive classical conditioning: Self-reports and physiological responses","authors":"Mykola Petrenko ,&nbsp;Lena Coenen ,&nbsp;Alice Doubliez ,&nbsp;Thomas M. Ernst ,&nbsp;Enzo Nio ,&nbsp;Nicolas Diekmann ,&nbsp;Metin Uengoer ,&nbsp;Sen Cheng ,&nbsp;Christian J. Merz ,&nbsp;Dagmar Timmann ,&nbsp;Giorgi Batsikadze","doi":"10.1016/j.bbr.2025.115509","DOIUrl":"10.1016/j.bbr.2025.115509","url":null,"abstract":"<div><div>Understanding the neural mechanisms underlying appetitive and aversive conditioning has important clinical implications because maladaptive associative learning processes are thought to contribute to various mental disorders, including anxiety, mood and eating disorders, as well as addiction and chronic pain. Since brain areas related to appetitive and aversive conditioning overlap with one another, but are probably also distinct, it is of interest to directly compare appetitive and aversive conditioning in behavioral and imaging studies. To what extent do behavioral outcome recordings in appetitive and aversive conditioning tasks match? We compared self-reports and physiological responses (skin conductance responses and pupil size) using commonly applied appetitive and aversive unconditioned stimuli (US) in 40 young and healthy participants (20 women). Different to animal studies, secondary reinforcers, particularly monetary rewards, are most commonly used as appetitive US in humans. Therefore, the first study compared self-reports and physiological assessments that were elicited by electric shock and three monetary rewards (one Euro, two Euros and five Euros). In the second study, differential aversive and appetitive conditioning were performed on two consecutive days with order being randomized between participants. Since outcome measures of electric shock best matched the one Euro reward, one Euro was used as US in the appetitive conditioning paradigm. In both studies, physiological responses were significantly lower towards appetitive conditioned stimuli (CS) and US compared to aversive CS and US (all <em>p</em>-values &lt; 0.001). Self-reports, on the other hand, showed much fewer differences in response magnitude and differential CS responding comparing appetitive and aversive CS and US. Overall, self-reports of valence were higher towards monetary rewards compared to the electrical stimulus considering both responses to the US in study 1 and CS in study 2 (<em>p</em>-values &lt; 0.001). Our findings show that full comparability between behavioral outcomes can probably not be achieved in appetitive and aversive conditioning paradigms since outcomes might easily diverge. Future studies comparing the neural responses in processing of aversive and appetitive stimuli using brain imaging, electroencephalography or other neurobiological methods need to control for possible differences in response magnitudes and learning rates.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115509"},"PeriodicalIF":2.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern-VEP findings in individuals with mild cognitive impairment","authors":"Mesude Kisli ,&nbsp;Hikmet Saçmacı","doi":"10.1016/j.bbr.2025.115504","DOIUrl":"10.1016/j.bbr.2025.115504","url":null,"abstract":"<div><h3>Background</h3><div>Visual evoked potential (VEP) is a technique used to evaluate the electrical response of the brain to visual stimuli. This study aimed to examine neural transmission in the visual pathway by VEP test in individuals with mild cognitive impairment (MCI) and compare it with age-appropriate controls and also investigate for a correlation between VEP parameters and cognitive test domains.</div></div><div><h3>Methods</h3><div>The groups consisted of 56 MCI and 50 healthy volunteers, aged 60–80 years, matched for age and education. Mini-Mental State Examination (MMSE) was applied to the participants for cognitive assessment. Patients were also subjected to other dementia screening tests and other treatable causes were excluded. In addition, groups were formed from those who completed the test. The pattern-reversal VEP method was used in this study.</div></div><div><h3>Results</h3><div>The mean MMSE score in the MCI group was 21.42 ± 1.55 points. Our findings showed that individuals with MCI had a longer left P100 latency compared to controls (p = 0.027). In addition, right N75-P100 and right P100-N145 amplitudes of VEP parameters were found to be positively correlated with the recall test, which is one of the MMSE domains (p &lt; 0.05, rho: 0.399,0.314).</div></div><div><h3>Conclusion</h3><div>The evidence provided by this study supports the possibility of using pattern VEP with clinical parameters to evaluate MCI patients. In addition, a positive correlation between interpeak amplitudes and the recall test highlights the importance of the VEP test in these patients.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115504"},"PeriodicalIF":2.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRMP2 in the hippocampus alleviates chronic stress-induced depressive-like behaviours in mice by affecting synaptic function","authors":"Ruiling Li ,&nbsp;Yuhui Zhang ,&nbsp;Honghan Zhang ,&nbsp;Chao Wang ,&nbsp;Hao Duan ,&nbsp;Siqi Sun ,&nbsp;Dan Xiang ,&nbsp;Zhongchun Liu","doi":"10.1016/j.bbr.2025.115495","DOIUrl":"10.1016/j.bbr.2025.115495","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a prevalent psychiatric illness and a significant contributor to the global burden of disease. However, the molecular mechanisms underlying depression are complex and have yet to be fully elucidated. Previous studies demonstrated that collapsin response mediator protein 2 (CRMP2) involved in the onset of depression, but its role is unclear yet. To explore the mechanism of CRMP2 in depression and whether it ameliorates depressive-like behaviours by modulating synaptic functions, we manipulate the expression of CRMP2 by adeno-associated virus (AAV) injected into the hippocampal CA1 region and then induced depressive-like behaviour by subjecting the mice to chronic unpredictable mild stress (CUMS). Sucrose preference test (SPT), open field test (OFT), elevated plus maze test (EPM), forced swimming test (FST), and tail suspension test (TST) are utilized to detect behavioral changes. Golgi-Cox staining and electron microscopy were applied to examine alterations in the structure and morphology of neural synapses. Synaptophysin (SYP), synaptophysin 1 (SYN1), growth-associated protein 43 (GAP43), glutamate receptor 2 (GLUR2) and postsynaptic density protein 95 (PSD95) is tested for synaptic function. The proteins interacting with CRMP2 were comprehensively investigated utilizing Immunoprecipitation-Mass Spectrometry (IP-MS) analysis and the direct binding between CRMP2 and PSD95 was validated. In our study, we observed CRMP2 in the hippocampal CA1 region was downregulated following CUMS. Knockdown of CRMP2 resulted in impaired synaptic structure and decreased expression of synapse-associated proteins, accompanied by increased depressive-like behaviour, like anhedonia and hopelessness. Conversely, overexpression of CRMP2 significantly ameliorated behavioural deficits associated with depression and restore the compromised synaptic structure and function. Our findings suggest that CRMP2 exerts a crucial function in modulating depressive-like behaviours by influencing the synaptic structure and function, and it can directly interact with PSD95.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115495"},"PeriodicalIF":2.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nigella sativa oil modulates neurobehavioral and neurochemical alterations in alcohol-exposed rats: An in vivo and in silico study","authors":"Beenish Asrar ,&nbsp;Muhammad Hassam ,&nbsp;Sidra Rafi ,&nbsp;Ikram Ullah ,&nbsp;Judith R. Homberg ,&nbsp;Darakhshan Jabeen Haleem","doi":"10.1016/j.bbr.2025.115494","DOIUrl":"10.1016/j.bbr.2025.115494","url":null,"abstract":"<div><h3>Background</h3><div>Chronic alcohol (ethanol) drinking changes central serotonin and dopamine levels, and thereby the functioning of brain circuits that support cognition and anxiety. Previously, it has been proven that <em>Nigella sativa</em> oil (NSO) improves cognition and reduces anxiety by regulating the neurotransmission but the underlying mechanisms are unknown.</div></div><div><h3>Methods</h3><div>To address the knowledge gap, an <em>in vivo</em> experiment was done to investigate effects of NSO on behavior and neurotransmission in ethanol drinking Wistar male rats. Specifically, control, NSO treated, ethanol and ethanol + NSO treated groups were tested for changes in anxiety-like behavior, locomotor activity and learning and memory using the elevated plus-maze test (EPM) and light and dark (L&amp;D) box test; open field test (OFT) and Morris water maze (MWM) test, respectively. Brain neurotransmitter concentrations were determined using HPLC-EC. To validate the <em>in vivo</em> findings, we assessed <em>in silico</em> the docking between NSO compounds and proteins using auto dock vina.</div></div><div><h3>Key findings</h3><div>Ethanol and NSO reduced weight in the ethanol and ethanol + NSO groups. Food intake, fluid consumption, calorie intake, and growth were similarly affected by ethanol and NSO. In the in behavioral tests, ethanol drinking rats spent less time in the open arms of the EPM and had fewer entries compared to controls, while ethanol + NSO group also showed reduced entries. Similar patterns were observed in the OFT. No differences were found in the L&amp;D box test. In the memory tests, ethanol + NSO treatment increased latency in short-term memory, while ethanol consumption increased latency in retention. Neurochemical analysis revealed that ethanol + NSO treatment increased serotonin levels in the PFC and hippocampus while reducing dopamine levels in the PFC compared to all groups, and in the hippocampus compared to control and NSO groups. The <em>in silico</em> experiment revealed that NSO has nine main active compounds. By molecular docking, we found that all nine compounds showed good binding affinity with our target proteins but the best docking values were obtained with thymoquinone and dithymoquinone. The binding affinity estimations identified the superior binding affinity and efficiency of dithymoquinone over all nine NSO compounds for serotonin, dopamine receptors and MAO-enzymes.</div></div><div><h3>Conclusions and significance</h3><div>NSO partially modulated ethanol induced neurobehavioral and neurochemical alterations, improving serotonin levels but not fully reversing behavioral deficits. Further studies are needed to explore its protective potential.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115494"},"PeriodicalIF":2.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the therapeutic promise of miRNAs in promoting amyloid-β clearance for Alzheimer's disease","authors":"Vajinder Kaur,&nbsp;Aditya Sunkaria","doi":"10.1016/j.bbr.2025.115505","DOIUrl":"10.1016/j.bbr.2025.115505","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a neurological disorder that affects cognition and behavior, accounting for 60–70 % of dementia cases. Its mechanisms involve amyloid aggregates, hyperphosphorylated tau tangles, and loss of neural connections. Current treatments have limited efficacy due to a lack of specific targets. Recently, microRNAs (miRNAs) have emerged as key modulators in AD, regulating gene expression through interactions with mRNA. Dysregulation of specific miRNAs contributes to disease progression by disrupting clearance pathways. Antisense oligonucleotide (ASO)-based therapies show promise for AD treatment, particularly when combined with miRNA mimics or antagonists, targeting complex regulatory networks. However, miRNAs can interact with each other, complicating cellular processes and potentially leading to side effects. Our review emphasizes the role of miRNAs in regulating amyloid-beta (Aβ) clearance and highlights their potential as therapeutic targets and early biomarkers for AD, underscoring the need for further research to enhance their efficacy and safety.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115505"},"PeriodicalIF":2.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study on effects of acute exposure to high altitude hypoxia on cognitive function in lowlander","authors":"Shuai Xu ,&nbsp;Zi-Yu Zheng ,&nbsp;Guang-Chao Zhao ,&nbsp;Zhi-Hong Lu ,&nbsp;Huang Nie ,&nbsp;Xue-Jun Wang ,&nbsp;Bin-Xiao Su ,&nbsp;Cheng Jiang ,&nbsp;Quan Li ,&nbsp;Tao He ,&nbsp;Tian-Yu Wei ,&nbsp;Hao-Peng Zhang ,&nbsp;Hai-Long Dong","doi":"10.1016/j.bbr.2025.115515","DOIUrl":"10.1016/j.bbr.2025.115515","url":null,"abstract":"<div><div>The investigation of cognitive functions in response to high-altitude exposure has garnered increasing scientific interest. However, it remains unclear whether cognitive abilities are selectively impaired or what are the trends of the function. In this study, we examined the effects of acute exposure to 3800 m on cognition among 20 lowlanders (27.9 ± 3.08 years; 18 males) for 1 week. Cognitive functions, physiological parameters, various questionnaires, and electroencephalogram (EEG) data were assessed at 400 m (D0) and during the acute phase at 3800 m (D1, D2, D3, D5, D7). A control group consisting of 23 subjects (26.5 ± 3.17 years; 21 males) underwent identical assessments at 400 m. Our findings indicate that within two days following ascent to 3800 m, nearly all cognitive indicators exhibited impairment, but gradually improved from the 3rd day and largely recovered to the plain level on the 5th to 7th day. EEG frequency analysis also revealed significant alterations, relative power in the delta band decreased markedly by D7 compared with D0, while theta and alpha bands showed the opposite trends. Correlational analyses between EEG features and cognitive functions revealed that relative power in the delta band exhibited a negative correlation with most cognitive measures, while relative power in the theta and beta bands predominantly demonstrated positive correlations. We conclude that most cognitive functions exhibit a pattern characterized by initial decline followed by recovery at 3800 m—an observation closely linked to observed EEG changes. These findings provide valuable insights into cognitive function and EEG performance at high altitudes.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"484 ","pages":"Article 115515"},"PeriodicalIF":2.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}