Altered gray matter networks in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder

IF 2.3 3区 心理学 Q2 BEHAVIORAL SCIENCES
Hongzhu Liu , Tong Li , Rui Qin , Lin Li , Congshan Ji , Xianshun Yuan , Baojin Chen , Cuicui Li , Ximing Wang
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引用次数: 0

Abstract

Although the comorbidity of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) (ASD+ADHD) is prevalent, the neurobiological mechanisms underlying this combined condition are not yet fully understood. Both ASD and ADHD have been associated with alterations in gray matter (GM) structural networks, suggesting that such altered GM networks may serve as potential markers for identifying this comorbid disorder. In this study, we compared the GM structural networks in ASD+ADHD, ASD without ADHD (ASD-only), ADHD without ASD (ADHD-only), and typically developing controls (TDc). Structural magnetic resonance imaging data of 41 individuals with ASD+ADHD, 53 individuals with ASD-only, 40 individuals with ADHD-only, and 62 TDc were obtained from the Autism Brain Imaging Data Exchange II and the ADHD-200 Sample databases. Graph theory analysis was employed to construct individual GM structural networks for each participant, followed by the calculation of topological metrics based on these networks. Our analysis revealed both common and disorder-specific nodal centralities alterations across the ASD+ADHD, ASD-only, and ADHD-only groups, compared with TDc. A significant correlation was found between the severity of symptoms and altered nodal centralities in the amygdala in the ASD+ADHD group. These findings support the Diagnostic and Statistical Manual of Mental Disorders-5 diagnosis of ASD+ADHD. Moreover, these findings provide novel neurobiological evidence for the ASD+ADHD comorbid state, which could lead to more targeted diagnostic and therapeutic approaches.
自闭症谱系障碍和注意缺陷多动障碍共发的灰质网络改变。
虽然自闭症谱系障碍(ASD)和注意力缺陷/多动障碍(ADHD) (ASD + ADHD)的共病很普遍,但这种联合病症的神经生物学机制尚未完全了解。ASD和ADHD都与灰质(GM)结构网络的改变有关,这表明这种改变的GM网络可能作为识别这种共病障碍的潜在标记物。在这项研究中,我们比较了ASD +ADHD、ASD无ADHD(仅ASD)、ADHD无ASD(仅ADHD)和典型发展对照组(TDc)的GM结构网络。从自闭症脑成像数据交换II和ADHD-200样本数据库中获得41例ASD + ADHD、53例ASD单纯性、40例ADHD单纯性和62例TDc的结构磁共振成像数据。利用图论分析为每个参与者构建GM结构网络,并在此基础上计算拓扑度量。我们的分析显示,与TDc相比,ASD + ADHD、ASD-only和ADHD-only组的常见和疾病特异性淋巴结中心性改变。在ASD + ADHD组中,症状的严重程度与杏仁核淋巴结中心性的改变之间存在显著的相关性。这些发现支持了《精神疾病诊断与统计手册-5》对ASD + ADHD的诊断。此外,这些发现为ASD + ADHD共病状态提供了新的神经生物学证据,这可能会导致更有针对性的诊断和治疗方法。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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