自闭症谱系障碍的营养治疗方法。

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-05-21 DOI:10.1016/j.bbr.2025.115653

Fernando Dobrachinski , Kátia Alves Ribeiro , Iverson Conrado Bezerra , Artur José da Silva , Camila Milagres Macedo Pereira , Kelle Vellasques , Heloísa Aiolfi Padilha , Sandra Elisa Haas , Daiana Silva Ávila , Priscila Gubert

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引用次数: 0

摘要

自闭症谱系障碍（ASD）是一种越来越普遍的神经发育疾病，其特点是在社会交往、沟通和感觉反应方面存在一定程度的困难。根据世界卫生组织的数据，每100名儿童中就有1名患有自闭症，许多因素可能导致大脑改变，比如遗传和环境因素。目前，自闭症谱系障碍还没有标准的治疗方法。值得注意的是，这种情况的标志之一是神经炎症，因为有人认为自闭症是由于慢性炎症反应引起的中枢神经系统紊乱，伴有小胶质细胞的激活。因此，抗氧化和抗炎化合物可能是减轻ASD受试者神经炎症影响的营养补充剂。本文综述了在临床前和临床试验中取得成功的主要分子，以及可能作为进一步研究策略的潜在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nutraceutical approaches for Autism Spectrum Disorder treatment

The Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that has been increasing in prevalence and is characterized by some degree of difficulty with social interaction, communication, and sensory response. According to the World Health Organization, ASD affects 1 in 100 children, and many factors may cause brain alterations, such as genetic and environmental factors. Currently, there is no standard treatment for ASD. Notably, one of the hallmarks of this condition is neuroinflammation since it has been suggested that autism results from central nervous system derangements due to chronic inflammatory reactions, with activation of microglial cells. Therefore, antioxidant and anti-inflammatory compounds may be nutraceutical supplements of interest to attenuate the impacts of neuroinflammation in ASD subjects. This review highlights the main molecules that have been successful in preclinical and clinical trials, as well as potential associations that might be further strategies to investigate.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.