产后第10天母亲分离诱导雄性大鼠抑郁样行为增加，海马树突棘减少，而焦虑样行为无变化

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-05-17 DOI:10.1016/j.bbr.2025.115617

Kento Takabayashi , Yuki Kajita , Hajime Mushiake

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引用次数: 0

摘要

神经发育有一个“敏感期”，在此期间大脑对经验高度敏感。在这项研究中，我们使用雌性分离（MS）模型来研究雄性龙-埃文斯大鼠在出生后10天（PND）后对应激的敏感性是否会发生变化，此时海马CA (Cornu amonis)1区的树突棘密度开始迅速增加。我们将幼崽分为三组：早期母崽分离组（EMS: PND 1-9期间MS）、晚期母崽分离组（LMS: PND 10-20期间MS）和对照组。成年期（PND 56 ~ 75，严格对应青年期），LMS表现为抑郁样行为增加，海马CA1区树突棘密度降低；然而，EMS没有显示出任何这样的变化。因此，PND 10-20的幼崽比PND 1-9的幼崽更容易患多发性硬化。这些发现表明，海马体中树突棘的形成是决定MS敏感性的一个重要因素。

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Maternal separation after postnatal day 10 induces increase in depression-like behavior with decrease in hippocampal dendritic spines, but no change in anxiety-like behavior in male rats

Neurodevelopment has a “sensitive period” during which the brain is highly sensitive to experience. In this study, we used maternal separation (MS) models of male Long-Evans rats to examine whether sensitivity to stress changes after postnatal day (PND) 10, when dendritic spine density begins to increase rapidly in the CA (Cornu Ammonis)1 region of the hippocampus.

We assigned littermates to three groups: early maternal separation group (EMS: MS during PND 1–9), late maternal separation group (LMS: MS during PND 10–20), and control group. During adulthood (PND 56–75, which strictly corresponds to young adulthood), LMS showed increased depression-like behaviors and decreased dendritic spine density in the CA1 hippocampal region; however, EMS did not show any such changes.

Accordingly, littermates at PND 10–20 have a greater vulnerability to MS than those at PND 1–9. These findings suggest that dendritic spine formation in the hippocampus is an important factor in determining sensitivity to MS.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.