Behavioural Brain Research最新文献_第2页

N-stearoyltyrosine attenuates ischemia-reperfusion injury by inhibiting caspase-dependent apoptosis and PARP-1/AIF-mediated parthanatos. n -硬脂酰酪氨酸通过抑制caspase依赖性细胞凋亡和PARP-1/ aif介导的旁咽炎来减轻缺血再灌注损伤。

IF 2.9 3区心理学

Behavioural Brain Research Pub Date : 2026-08-30 DOI: 10.1016/j.bbr.2026.116439

Rui Yang, Jing Ma, Kejia Le, Yang Lu

{"title":"N-stearoyltyrosine attenuates ischemia-reperfusion injury by inhibiting caspase-dependent apoptosis and PARP-1/AIF-mediated parthanatos.","authors":"Rui Yang, Jing Ma, Kejia Le, Yang Lu","doi":"10.1016/j.bbr.2026.116439","DOIUrl":"10.1016/j.bbr.2026.116439","url":null,"abstract":"<p><p>Cerebral ischemia‑reperfusion (I/R) injury induces neuronal death via caspase-dependent apoptosis and parthanatos, a poly (ADP-ribose) polymerase 1 (PARP-1)/apoptosis-inducing factor (AIF)-mediated caspase-independent pathway. Simultaneous inhibition of these pathways may provide enhanced neuroprotection. N-Stearoyltyrosine (NsTyr), a synthetic analogue of the endocannabinoid anandamide (AEA), exhibits neuroprotective effects in various models, however, its efficacy and mechanism in middle cerebral artery occlusion (MCAO) remain unclear. Neuronal oxygen-glucose deprivation/ reoxygenation (OGD/R) and rat MCAO models were employed to evaluate the neuroprotection of NsTyr. Neuronal viability and apoptosis were assessed using MTT assay, flow cytometry, TUNEL staining, and Hoechst 33342 staining. The cognitive impairment was evaluated using the Morris water maze. Mitochondrial function and ultrastructure were eassessed by JC-1 assay and transmission electron microscopy (TEM). Expression levels of key apoptotic-related proteins were determined by immunoblotting. Intracellular NAD⁺ and ATP levels were measured to assess PARP-1 activity. NsTyr significantly improved neuronal survival, reduced apoptosis, and ameliorated cognitive deficits in both in vitro and in vivo models. Mechanistically, NsTyr preserved mitochondrial integrity, maintained the Bcl-2/Bax balance, suppressed cytochrome c release and caspase-3 activation, and inhibited nuclear translocation of AIF. Concurrently, NsTyr attenuated PARP-1 overactivation, preserved NAD⁺ and ATP levels, and thereby suppressed parthanatos. These findings demonstrate that NsTyr confers potent neuroprotection against I/R injury by dual inhibition of caspase-dependent apoptosis and PARP-1/AIF-mediated parthanatos through the maintenance of mitochondrial integrity, supporting its potential as a therapeutic candidate for ischemic stroke.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116439"},"PeriodicalIF":2.9,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferulic acid eicosyl ester enhances cognitive flexibility and modulates arousal-related neural circuits in mice. 阿魏酸二十烷酯增强小鼠的认知灵活性和调节觉醒相关的神经回路。

IF 2.9 3区心理学

Behavioural Brain Research Pub Date : 2026-08-30 DOI: 10.1016/j.bbr.2026.116451

Dana Mayer, Iman Hassan, Firat Taskaya, Afsana Chowdhury, Evelyn Kahl, Thomas Endres, Volkmar Leßmann, Bertram Gerber, Markus Fendt

{"title":"Ferulic acid eicosyl ester enhances cognitive flexibility and modulates arousal-related neural circuits in mice.","authors":"Dana Mayer, Iman Hassan, Firat Taskaya, Afsana Chowdhury, Evelyn Kahl, Thomas Endres, Volkmar Leßmann, Bertram Gerber, Markus Fendt","doi":"10.1016/j.bbr.2026.116451","DOIUrl":"10.1016/j.bbr.2026.116451","url":null,"abstract":"<p><p>Cognitive deficits are a major contributor to disability in numerous neuropsychiatric and neurodegenerative disorders, yet effective pharmacological treatments remain limited. Ferulic acid eicosyl ester (FAE-20), a natural constituent of the plant Rhodiola rosea, has previously been identified as an enhancer of simple forms of Pavlovian conditioning in flies, bees, and mice. Here, we investigated whether FAE-20 has further potential to enhance cognitive flexibility, working memory, or spatial learning in mice, and explored potential neurobiological mechanisms underlying such enhancement. Cognitive flexibility was assessed using the attentional set-shifting task (ASST). Subchronic FAE-20 treatment significantly improved ASST performance in both male and female young adult mice, indicating enhanced cognitive flexibility. In contrast, no effects were observed on spatial working memory, assessed by spontaneous alternations in the Y-maze, or on spatial learning in the Barnes maze in either young or aged mice. Notably, FAE-20 enabled spatial learning in the Barnes maze in a subgroup of aged mice that failed to learn the task under vehicle treatment. Histological analyses using c-Fos immunohistochemistry as a marker of neural activity and doublecortin expression and spine density as markers of hippocampal plasticity revealed sex-specific effects on components of the ascending arousal system. FAE-20 increased the activation of orexinergic neurons in the lateral hypothalamus of male mice, whereas it reduced the activity of cholinergic neurons in the laterodorsal tegmental nucleus of females. No effects were detected on hippocampal neurogenesis or dendritic spine density. These findings suggest that the cognitive effects of FAE-20 are selective, depending on the cognitive demands of the task and the baseline cognitive abilities of the animals, and may be mediated, at least in part, by modulation of arousal-related neural circuits.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116451"},"PeriodicalIF":2.9,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The appetite for freediving differs between Sprague-Dawley and Long Evans rats. Sprague-Dawley大鼠和Long Evans大鼠对自由潜水的兴趣不同。

IF 2.9 3区心理学

Behavioural Brain Research Pub Date : 2026-08-30 DOI: 10.1016/j.bbr.2026.116445

Laëtitia Chambrun, Jorelle Linda Damo Kamda, Laurent Vatrinet, Harquin Simplice Foyet, Roseline Poirier, Valérie Doyère, Marion Noulhiane

{"title":"The appetite for freediving differs between Sprague-Dawley and Long Evans rats.","authors":"Laëtitia Chambrun, Jorelle Linda Damo Kamda, Laurent Vatrinet, Harquin Simplice Foyet, Roseline Poirier, Valérie Doyère, Marion Noulhiane","doi":"10.1016/j.bbr.2026.116445","DOIUrl":"https://doi.org/10.1016/j.bbr.2026.116445","url":null,"abstract":"<p><p>Freediving in rats has emerged as a relevant model to study physiology and neural adaptation underlying submersion mechanisms. However, despite well-established strain-dependent differences in behavior and physiological responses, most studies about freediving rely on Sprague Dawley rats. As the choice of strain could significantly shape experimental results depending on the field of research, we conducted a behavioral comparative study between Long Evans (LE) rats, genetically closer to the Wild Norway rat, with the commonly used Sprague Dawley (SD) strain. We developed an 11-week progressive voluntary freediving protocol involving four distances (from 5 to 11 meters), and assessed the rats' natural willingness to dive and swim, and identified several parameters for evaluation of their confidence (waiting time before diving, speed), performance capacity (freediving time) and population variability. We found that Long Evans rats were naturally more willing to dive and more confident, compared to Sprague Dawley rats: they showed better performance with longer time underwater and slower diving speed. We also uncover differences in their variability, at trial-to-trial intra-individual and population inter-individual levels, which can guide the choice of one strain over the other, depending on the aim of the scientific inquiry.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116445"},"PeriodicalIF":2.9,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The alpha-2A adrenoceptor agonist guanfacine regulates traumatic stress processing in juvenile zebrafish. α - 2a肾上腺素受体激动剂胍法辛调节幼年斑马鱼的创伤应激加工。

IF 2.9 3区心理学

Behavioural Brain Research Pub Date : 2026-08-27 DOI: 10.1016/j.bbr.2026.116448

C van Staden, D Weinshenker, K Finger-Baier, T L Botha, L Brand, D Wolmarans

{"title":"The alpha-2A adrenoceptor agonist guanfacine regulates traumatic stress processing in juvenile zebrafish.","authors":"C van Staden, D Weinshenker, K Finger-Baier, T L Botha, L Brand, D Wolmarans","doi":"10.1016/j.bbr.2026.116448","DOIUrl":"10.1016/j.bbr.2026.116448","url":null,"abstract":"<p><p>Early-life stress (ELS), i.e., traumatic events during vulnerable developmental periods, adversely affects adult psychobiological outcomes, with dysregulated noradrenergic processing of trauma proposed to play a role. Guanfacine, a selective alpha-2A adrenergic receptor agonist that blunts noradrenergic signalling in mammals by activating the alpha-2A inhibitory autoreceptor, may be useful to attenuate the long-term consequences of ELS. The zebrafish (Danio rerio) is extensively used in stress research. Here, we investigated the immediate and long-term effects of a traumatic ELS procedure combined with control or guanfacine (20 µg/L) treatment in 264 juvenile zebrafish. Immediate assessments in 168 juveniles included anxiety-like and risk-taking behaviours using the light-dark test (LDT) and open field test (OFT). Long-term assessments in 96 fish raised to adulthood included anxiety-like behaviour using the novel tank test (NTT) and open field avoidance and aggressor-directed risk-taking behaviour in a novel OFT (nOFT). We found that traumatic stress exposure only modestly impacted the immediate anxiety-like behaviours of juvenile zebrafish, while guanfacine had distinct stress-dependent effects on behaviour. Guanfacine elicited anxiety-like behaviours under conditions of novelty (i.e., testing in the absence of a prior traumatic experience), but had the opposite effect and suppressed anxiety-like behaviours in trauma-exposed fish. Our results also showed that zebrafish exhibit a high degree of resilience to the long-term impact of traumatic stress, as neither traumatic stress exposure, nor guanfacine administration, affected anxiety-like or risk-taking behaviours in adulthood. These findings illustrate the presence of evolutionary conserved adaptive neurobiological mechanisms in zebrafish that may blunt the impact of traumatic events.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116448"},"PeriodicalIF":2.9,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding ruminative states from neurophysiological patterns. 从神经生理模式解码沉思状态。

IF 2.9 3区心理学

Behavioural Brain Research Pub Date : 2026-08-27 DOI: 10.1016/j.bbr.2026.116450

Jana Welkerling, Patrick Schneeweiss, Sebastian Wolf, Tim Rohe

{"title":"Decoding ruminative states from neurophysiological patterns.","authors":"Jana Welkerling, Patrick Schneeweiss, Sebastian Wolf, Tim Rohe","doi":"10.1016/j.bbr.2026.116450","DOIUrl":"10.1016/j.bbr.2026.116450","url":null,"abstract":"<p><p>Individuals with depression often engage in iterative \"rumination\" about challenging situations and potential outcomes. Although the state of rumination has been associated with diverse univariate neurophysiological features, the potential to use multivariate patterns to decode it remains uncertain. In this proof-of-principle study, we trained participant-specific linear support vector machines to differentiate state rumination from distraction using patterns in the alpha, beta, and theta bands, as well as inter-channel connectivity. We used validated tasks to induce rumination or distraction for eight minutes in 24 depressed individuals in six runs over three sessions. During inductions, we recorded 64-channel EEG data and measured self-reported levels of rumination. Participants reported strongly increased rumination, and averaged across all participant-specific decoders we classified state rumination from EEG patterns with small albeit significant accuracy. However, on an individual level, decoding reached accuracies above chance level in only 10 out of 24 participants with heterogenous feature weights across individuals. Our study demonstrates that ruminative states can be decoded from inter-individually heterogenous neurophysiological patterns, but variability in ruminative processes limits the generalization of decoding approaches across participants.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116450"},"PeriodicalIF":2.9,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148824738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociable roles of lateral orbitofrontal and medial prefrontal cortex in risk-based decision-making under equal expected value in rats. 等期望值下外侧眶额皮层和内侧前额叶皮层在大鼠风险决策中的分离作用。

IF 2.9 3区心理学

Behavioural Brain Research Pub Date : 2026-08-25 DOI: 10.1016/j.bbr.2026.116446

Yi-Hua Yang, Chih-Yi Chen, Shuo-Fu Chen, Lee-Xieng Yang, Ruey-Ming Liao

{"title":"Dissociable roles of lateral orbitofrontal and medial prefrontal cortex in risk-based decision-making under equal expected value in rats.","authors":"Yi-Hua Yang, Chih-Yi Chen, Shuo-Fu Chen, Lee-Xieng Yang, Ruey-Ming Liao","doi":"10.1016/j.bbr.2026.116446","DOIUrl":"10.1016/j.bbr.2026.116446","url":null,"abstract":"<p><p>The prefrontal cortex (PFC) plays a critical role in decision-making under uncertainty. Although prior studies have shown that PFC subregions influence risky choice in tasks manipulating reward probability, their contributions to decision-making across different levels of risk, independent of expected value, remain unclear. In the present study, we examined the effects of excitotoxic lesions of the lateral orbitofrontal cortex (lOFC) and the medial PFC (mPFC) on a novel T-maze risk choice task in male rats. In this task, expected value was held constant across choice options, while outcome variance was manipulated using three reward ratios corresponding to low, medium, and high levels of risk. Control rats developed distinct choice patterns across risk levels, exhibiting risk-prone behavior under low risk and risk-averse behavior under high risk. The acquisition of risk-dependent choice was differentially modulated by lOFC and mPFC lesions, with more pronounced effects of lOFC lesions under the low-risk condition. Microstructural analysis revealed that lOFC lesions altered sensitivity to negative feedback, as reflected by decreased lose-stay and increased lose-shift responses. Computational modeling further indicated that lOFC function was associated with reward learning and choice persistence, whereas mPFC function was related to learning from both reward and punishment outcomes. Together, these results demonstrate dissociable roles of the lOFC and mPFC in risk-dependent decision-making. Specifically, the lOFC plays a critical role in stabilizing choice behavior under low-risk conditions, likely by modulating choice persistence in response to negative feedback, a function that may contribute to the processing of outcome variability during risk-dependent choice.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116446"},"PeriodicalIF":2.9,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Escitalopram and N-acetylcysteine alleviate major depressive disorder with cognitive impairment through YTHDC1/ATF4/CHOP-mediated pyroptosis. 艾司西酞普兰和n -乙酰半胱氨酸通过YTHDC1/ATF4/ chop介导的焦亡缓解重度抑郁症伴认知障碍。

IF 2.9 3区心理学

Behavioural Brain Research Pub Date : 2026-07-27 DOI: 10.1016/j.bbr.2026.116403

Yuting Zhou, Yuqian Zhang, Lixia Yang

{"title":"Escitalopram and N-acetylcysteine alleviate major depressive disorder with cognitive impairment through YTHDC1/ATF4/CHOP-mediated pyroptosis.","authors":"Yuting Zhou, Yuqian Zhang, Lixia Yang","doi":"10.1016/j.bbr.2026.116403","DOIUrl":"10.1016/j.bbr.2026.116403","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment (CI) is an important factor contributing to poor prognosis in major depressive disorder (MDD). Endoplasmic reticulum stress and microglial inflammatory response are closely associated with the occurrence and development of MDD with CI. Escitalopram (ESC) and N-acetylcysteine (NAC) are two drugs used to improve depression. However, the therapeutic efficacy and underlying molecular mechanisms of ESC and NAC in treating MDD with CI are still not fully understood.</p><p><strong>Methods: </strong>The depression rat was established using the chronic unpredictable mild stress (CUMS) protocol. The antidepressant effects of ESC and NAC were evaluated through behavioral tests including the open field test, sucrose preference test, and Morris water maze test and. The underlying molecular mechanisms were investigated using ELISA and immunofluorescence techniques.</p><p><strong>Results: </strong>The CUMS group of rats showed decreased responsiveness and memory capacity, which were significantly improved following intervention with ESC and NAC. Treatment with ESC and NAC alleviated hippocampal injury in the CUMS group of rats. The expression of microglial activation markers CD68 and IBA1 in hippocampal tissue was significantly reduced. The levels of NLRP3 inflammasome and pro-inflammatory cytokines IL-6, IL-18, and IL-1β in the hippocampus were significantly decreased. Mechanistically, ESC and NAC downregulate ATF4/CHOP expression by inhibiting the m6A reader YTHDC1, thereby reducing hippocampal cell pyroptosis.</p><p><strong>Conclusion: </strong>This study demonstrates that ESC and NAC alleviate hippocampal tissue damage by modulating YTHDC1/ATF4/CHOP-mediated pyroptosis, thereby improving MDD with CI. These findings provide experimental evidence supporting the therapeutic potential of targeting YTHDC1/ATF4/CHOP-mediated pyroptosis in MDD-associated CI.</p>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"116403"},"PeriodicalIF":2.9,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-pharmacotherapy for craving in methamphetamine use disorder: A systematic review and network meta-analysis of randomised controlled trials 非药物治疗对甲基苯丙胺使用障碍的渴望：随机对照试验的系统回顾和网络荟萃分析。

IF 2.3 3区心理学

Behavioural Brain Research Pub Date : 2026-04-27 Epub Date: 2026-02-06 DOI: 10.1016/j.bbr.2026.116084

Jisheng Xu , Xue Li , Zhicheng Zhu , Junwei Wang , Yan Yang , Xulin Zhou , Guosi Ying

{"title":"Non-pharmacotherapy for craving in methamphetamine use disorder: A systematic review and network meta-analysis of randomised controlled trials","authors":"Jisheng Xu , Xue Li , Zhicheng Zhu , Junwei Wang , Yan Yang , Xulin Zhou , Guosi Ying","doi":"10.1016/j.bbr.2026.116084","DOIUrl":"10.1016/j.bbr.2026.116084","url":null,"abstract":"<div><h3>Objectives</h3><div>We evaluated the effects of non-pharmacotherapy on quality of life (QOL) and craving in individuals with methamphetamine use disorder (MUD), ranking the efficacy of various protocols.</div></div><div><h3>Methods</h3><div>We searched multiple databases for randomized controlled trials from inception to Dec 2025. The analysis included 53 studies with 3174 participants, investigating interventions such as exercise, transcranial magnetic stimulation (TMS), transcranial direct current stimulation, behavioral therapy, and acupuncture. The protocol was prospectively registered in PROSPERO (CRD42023443291).</div></div><div><h3>Results</h3><div>For craving reduction, both exercise and TMS demonstrated statistically significant benefits compared to conventional rehabilitation. Combined aerobic/resistance exercise and 10 Hz repetitive TMS targeting the left dorsolateral prefrontal cortex emerged as the most effective specific protocols within their respective categories. Furthermore, preliminary evidence from a limited number of studies indicated that exercise, acupuncture, and behavioral therapy improved patients' QOL.</div></div><div><h3>Conclusion</h3><div>This study confirms that several non-pharmacotherapies are effective for managing craving in MUD. Exercise and TMS are particularly promising for reducing craving. The findings, synthesized within a novel \"Intervention-Circuit-Symptom\" integrative framework, provide a robust evidence base to inform clinical decision-making and guide the future development of MUD treatment guidelines.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"504 ","pages":"Article 116084"},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined transcranial electrical stimulation (tES) and cognitive training (CT) for cognitive impairment: Evidence from clinical applications and basic research 联合经颅电刺激（tES）和认知训练（CT）治疗认知障碍：来自临床应用和基础研究的证据。

IF 2.3 3区心理学

Behavioural Brain Research Pub Date : 2026-04-27 Epub Date: 2026-02-02 DOI: 10.1016/j.bbr.2026.116078

Shu Xing , Yuan Yuan , Ping Ren , Zhuangfei Chen , Yu Fu

{"title":"Combined transcranial electrical stimulation (tES) and cognitive training (CT) for cognitive impairment: Evidence from clinical applications and basic research","authors":"Shu Xing , Yuan Yuan , Ping Ren , Zhuangfei Chen , Yu Fu","doi":"10.1016/j.bbr.2026.116078","DOIUrl":"10.1016/j.bbr.2026.116078","url":null,"abstract":"<div><div>Cognitive impairment is a serious pathological feature of neuropsychiatric disorders, making the exploration of effective treatments urgent. Recent research shows that combined transcranial electrical stimulation (tES) and cognitive training (CT) can reduce cognitive deficits. This review summarizes studies on neurological disorders that use both clinical patients and rodent models to highlight the underlying neural mechanisms. In patients, this combined approach improves cognitive domains such as attention, working memory, and executive function. Improvements have been observed in patients with mild cognitive impairment (MCI), dementia (e.g., Alzheimer’s disease (AD)), Parkinson’s disease (PD), stroke, traumatic brain injury (TBI), multiple sclerosis, schizophrenia, attention deficit hyperactivity disorder (ADHD) and depression, as well as in healthy populations. In contrast, studies on the combined intervention are lacking in rodent models of disease. However, tES and CT separately improve spatial learning and memory in AD, TBI, schizophrenia, ADHD, and healthy animals, as well as in models of vascular dementia and cerebral ischemia. The combined intervention regulates and remodels functional connectivity in brain networks, and improves cerebrovascular microcirculation and glutamatergic neurotransmission. Importantly, tES and CT may enhance each other through cooperative and complementary effects. In addition, some studies have reported the limited efficacy or negative outcomes of combined and single interventions, which may be due to suboptimal parameters or techniques that fail to target key pathologies. Future clinical trials should explore tES-CT combination strategies targeting disease-specific brain regions. Furthermore, animal studies must be strengthened to elucidate the potential mechanisms and interactions of tES and CT.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"504 ","pages":"Article 116078"},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of acute and repeated adolescent MDMA exposure on behavior, cognition, and the monoamine neurotransmitter systems: A review of human and pre-clinical research 青少年MDMA急性和反复暴露对行为、认知和单胺神经递质系统的影响：人类和临床前研究综述

IF 2.3 3区心理学

Behavioural Brain Research Pub Date : 2026-04-27 Epub Date: 2026-02-10 DOI: 10.1016/j.bbr.2026.116098

Kristin A. Felsch, Jessica A. Siegel

{"title":"The effects of acute and repeated adolescent MDMA exposure on behavior, cognition, and the monoamine neurotransmitter systems: A review of human and pre-clinical research","authors":"Kristin A. Felsch, Jessica A. Siegel","doi":"10.1016/j.bbr.2026.116098","DOIUrl":"10.1016/j.bbr.2026.116098","url":null,"abstract":"<div><div>3,4-methylenedioxymethamphetamine (MDMA) is a psychomotor stimulant drug. While much research has examined the effects of MDMA in adults, relatively little research has examined the effects in adolescents. Adolescence is a unique period of brain development, and the effects of MDMA may differ in adolescents compared to adults. In this review, we summarize the literature on the effects of acute and repeated adolescent MDMA exposure on behavior, cognition, and the monoamine neurotransmitter systems in adolescent rodents and humans. PubMed was searched using predefined criteria, resulting in the evaluation of 1012 articles. Fifty-four articles met the search criteria, 48 of which examined the effects of adolescent MDMA exposure in adolescent rodents and 6 of which examined the effects in adolescent humans. Studies measuring the effects of acute MDMA exposure examine outcome measures following a single exposure to MDMA, and studies measuring the effects of repeated MDMA exposure examine outcome measures at some point following multiple exposures to MDMA. Exposure to acute higher doses of MDMA generally increases locomotor activity and causes impairments in the serotonin neurotransmitter system. The literature on the effects of repeated adolescent MDMA exposure shows conflicting results, and the findings are dependent on the dosing, testing environment, and timing of testing following MDMA exposure. There is a lack of literature examining the effects of MDMA in adolescent females. More research is needed with consistent exposure and dosing paradigms and in female subjects to better understand the effects of adolescent MDMA exposure.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"504 ","pages":"Article 116098"},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0