Behavioural Brain Research最新文献_第2页

Effects of astrocytes in the dorsal hippocampus on anxiety-like and depressive-like behaviors in hemiparkinsonian rats

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-25 DOI: 10.1016/j.bbr.2025.115553

Yi-Wei Hu , Jian Liu , Zi-Han Qiu , Xiao-Ying Li , Juan Li , Li Chen , Tao Wang , Xin-Feng Wang , Zhong-Jie Feng , Wan-Ting Bai , Yuan Guo , Li Zhang

{"title":"Effects of astrocytes in the dorsal hippocampus on anxiety-like and depressive-like behaviors in hemiparkinsonian rats","authors":"Yi-Wei Hu , Jian Liu , Zi-Han Qiu , Xiao-Ying Li , Juan Li , Li Chen , Tao Wang , Xin-Feng Wang , Zhong-Jie Feng , Wan-Ting Bai , Yuan Guo , Li Zhang","doi":"10.1016/j.bbr.2025.115553","DOIUrl":"10.1016/j.bbr.2025.115553","url":null,"abstract":"<div><div>Anxiety and depression are the most common neuropsychiatric manifestations of Parkinson’s disease (PD) patients. Growing evidence have shown that the dorsal hippocampus (dHIPP) and astrocytes (AS) may be involved in regulating depression and anxiety, but the role and mechanism are still unclear, especially in PD-related depression and anxiety. Unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta (SNc) were used to establish the rat model of PD. Behavioral tests and measurement of monoamine levels in the depression and anxiety related brain regions were performed to investigate the effects of chemogenetic activation or inhibition of dHIPP AS on PD-related anxiety and depression. The present results showed that unilateral lesions of the SNc induced anxiety-like and depressive-like behaviors, decreased dopamine (DA) levels in some related brain regions, but did not change the density of glial fibrillary acidic protein-positive AS in the CA1, CA3 and dentate gyrus in rats. Chemogenetic inhibition of dHIPP AS significantly improved anxiety-like and depressive-like behaviors only in the lesioned rats, while chemogenetic activation of dHIPP AS had no effects on anxiety-like and depressive-like behaviors in sham-operated and the lesioned rats. Chemogenetic activation of dHIPP AS only decreased DA level in the ventral hippocampus (vHIPP) in sham-operated rats, while inhibition of dHIPP AS increased 5-hydroxytryptamine (5-HT) levels in the medial prefrontal cortex (mPFC) and vHIPP in sham-operated rats and also in the amygdala, mPFC, lateral habenula, dHIPP and vHIPP in the lesioned rats. These results indicate that chemogenetic inhibition of dHIPP AS improves the anxiety-like and depressive-like behaviors in the lesioned rats through the changes in monoamine in some brain regions.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"486 ","pages":"Article 115553"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanistic role of piracetam in the management of vascular dementia

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-24 DOI: 10.1016/j.bbr.2025.115551

Hayder M. Al-kuraishy , Ali I. Al-Gareeb , Duaa Eliwa , Athanasios Alexiou , Marios Papadakis , Mubarak Alruwaili , Gaber El-Saber Batiha

{"title":"The mechanistic role of piracetam in the management of vascular dementia","authors":"Hayder M. Al-kuraishy , Ali I. Al-Gareeb , Duaa Eliwa , Athanasios Alexiou , Marios Papadakis , Mubarak Alruwaili , Gaber El-Saber Batiha","doi":"10.1016/j.bbr.2025.115551","DOIUrl":"10.1016/j.bbr.2025.115551","url":null,"abstract":"<div><div>Piracetam is a cyclic derivative of gamma aminobutyric acid, has a neuroprotective effect against neurodegenerative disease by inhibiting neuroinflammation. Piracetam augments the effect of acetylcholine on the muscarinic receptors thereby improving learning and memory. In addition, piracetam through modulation of ion channels increases the activity of different neurotransmitters involved in cognitive function. Excitingly, piracetam improves blood flow by increasing erythrocyte deformability and reducing adhesion of erythrocytes to the vascular endothelium by inhibiting fibrinogen; thus, it improves microcirculation and can be used in the management of vascular dementia (VaD). Also, piracetam improves cognitive function in VaD by reducing mitochondrial dysfunction and oxidative stress. Hence, piracetam has a neuroprotective effect against VaD. However, the exact neuroprotective mechanism of piracetam against the development and progression of VaD was not fully clarified. Consequently, this review attempts to discuss the potential effect of piracetam in VaD.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"486 ","pages":"Article 115551"},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of anxiety induced by conditioned fear on the expression of NMDA receptors and synaptic plasticity in the rat BLA

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-23 DOI: 10.1016/j.bbr.2025.115547

Yue-Heng Yan, Hong-Kun Wang, Zi-Hao Wang, Rui-Ze Wang, Ruo-Xuan Li, Li-Li Huang, Yan-Yan Wang

{"title":"Effects of anxiety induced by conditioned fear on the expression of NMDA receptors and synaptic plasticity in the rat BLA","authors":"Yue-Heng Yan, Hong-Kun Wang, Zi-Hao Wang, Rui-Ze Wang, Ruo-Xuan Li, Li-Li Huang, Yan-Yan Wang","doi":"10.1016/j.bbr.2025.115547","DOIUrl":"10.1016/j.bbr.2025.115547","url":null,"abstract":"<div><div>NMDA receptors (NMDAR) are vital in CNS activities such as anxiety, memory, and cognition, and the neurobiological mechanisms behind anxiety disorders are exceedingly complicated. The \"glutamic acid theory\" posits that glutamate excitotoxicity is a key pathophysiological mechanism in anxiety disorders. However, the exact mechanism by which conditioned fear contributes to anxiety disorders remains unknown.Based on the conditioned fear-induced anxiety disorder model, this work aims to investigate changes in NMDAR and related proteins throughout the acquisition and expression of fear memory, as well as the impact on synaptic structural and functional plasticity. Injecting the NMDA receptor endogenous agonist D-Serine (50 μg/μL) and the noncompetitive antagonist MK-801 (1 μg/μL) into the lateral ventricle of the conditioned fear model rats, as well as conducting behavioral observations, show that NMDAR are closely involved in the development of conditioned fear-induced anxiety. Model rats showed significant changes in glutamate (Glu) and γ-aminobutyric acid (GABA) levels in the amygdala (BLA), as well as expression of NMDAR and downstream BDNF/TrkB signaling pathway components. At the same time, model rats exhibited synaptic and neuronal injury, aberrant long-term potentiation (LTP), and decreased expression of essential synaptic proteins SYP and PSD-95. In conclusion, our study demonstrates that NMDAR and synaptic plasticity play a critical role in the development of conditioned fear-induced anxiety, serving as an important reference for understanding the neurobiological underpinnings of anxiety disorders and providing insights into their treatment and new possible targets.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"486 ","pages":"Article 115547"},"PeriodicalIF":2.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotrophic factor neuritin ameliorates streptozotocin-induced Alzheimer's disease-like impairment of memory, neuroinflammation, apoptotic factors and compensates hippocampal neuritin expression

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-22 DOI: 10.1016/j.bbr.2025.115542

Mandana Kazemi , Saeed Esmaeili-Mahani , Mehdi Abbasnejad , Vahid Sheibani

{"title":"Neurotrophic factor neuritin ameliorates streptozotocin-induced Alzheimer's disease-like impairment of memory, neuroinflammation, apoptotic factors and compensates hippocampal neuritin expression","authors":"Mandana Kazemi , Saeed Esmaeili-Mahani , Mehdi Abbasnejad , Vahid Sheibani","doi":"10.1016/j.bbr.2025.115542","DOIUrl":"10.1016/j.bbr.2025.115542","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is the main cause of dementia in the elderly, and is becoming one of the most expensive and deadly diseases. Deficiency of neurotrophic factors signaling is an important cause of this disease. Therefore, we investigated whether neuritin as a neurotrophic factor can have a neuroprotective effect against streptozotocin (STZ)-induced rat model of AD. The animals were bilaterally injected with intra hippocampal-STZ (3 mg/kg). Different concentrations of neuritin (0.5, 1, 1.5 µg/rat) were administrated 15 min before STZ injection. After 14 days, the rats were evaluated for cognitive performance using novel object recognition (NOR), open field and Morris water maze (MWM) tests and then sacrificed for biochemical analysis (by real-time PCR and western blot examinations). The results demonstrated that the STZ- induced learning and memory impairments were significantly prevented by 1.5 µg neuritin. Moreover, the increased levels of inflammatory factors (NF-κb, TNF-α and IL-1β) and apoptotic parameters (cytochrome c and caspase‑3) in STZ- treated rats were also significantly decreased by neuritin. In addition, hippocampal neuritin gene expression was downregulated by STZ injection, which was reversed by intra hippocampal neuritin injection. In conclusion, the present study suggests that neuritin prevents cognitive defects in AD rat model and its expression level is associated with cognitive resilience.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"486 ","pages":"Article 115542"},"PeriodicalIF":2.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain remodeling in stroke patients: A comprehensive review of mechanistic and neuroimaging studies

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-21 DOI: 10.1016/j.bbr.2025.115548

Jing Wang , Jian Zhou , Jing Zhu , Jinping Sheng , Rui Jiang , Xiao Zhang

{"title":"Brain remodeling in stroke patients: A comprehensive review of mechanistic and neuroimaging studies","authors":"Jing Wang , Jian Zhou , Jing Zhu , Jinping Sheng , Rui Jiang , Xiao Zhang","doi":"10.1016/j.bbr.2025.115548","DOIUrl":"10.1016/j.bbr.2025.115548","url":null,"abstract":"<div><div>Stroke-induced brain remodeling involves a complex interplay of neurovascular components, including endothelial cells, microglia, astrocytes, and pericytes, which collectively contribute to the restoration of brain function. These processes are crucial for repairing the blood-brain barrier, regulating inflammation, and promoting neurogenesis. This review examines the mechanisms underlying brain remodeling and the role of advanced neuroimaging techniques—such as functional MRI (fMRI), positron emission tomography (PET), functional near-infrared spectroscopy (fNIRS), and functional ultrasound (fUS)—in assessing these changes. We also discuss various therapeutic approaches aimed at enhancing brain remodeling, including pharmacological agents, stem cell therapy, and rehabilitation strategies that target neurovascular repair and functional recovery. Despite significant progress, challenges remain in translating imaging insights into effective treatments. Future research should focus on integrating multiple imaging modalities to provide a comprehensive view of neurovascular changes and refining therapeutic interventions to optimize recovery and functional outcomes in stroke patients.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"486 ","pages":"Article 115548"},"PeriodicalIF":2.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the comorbid mechanisms of sarcopenia and late-life depression

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-21 DOI: 10.1016/j.bbr.2025.115538

Jiale Wu , Jun Tang, Di Huang, Yu Wang, Enyuan Zhou, Qin Ru, Guodong Xu, Lin Chen, Yuxiang Wu

引用次数: 0

Targeted suppression of BRD7 with BI-9564 prevents seizure behaviors in pentylenetetrazol and pilocarpine-induced mouse model of epilepsy

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-20 DOI: 10.1016/j.bbr.2025.115549

Jie Chen , Yujia Li , Xiaofei Huo , Ziqiang Huang , Suyun Li , Wenyu Cao , Cuilan Zhou , Yang Xu

{"title":"Targeted suppression of BRD7 with BI-9564 prevents seizure behaviors in pentylenetetrazol and pilocarpine-induced mouse model of epilepsy","authors":"Jie Chen , Yujia Li , Xiaofei Huo , Ziqiang Huang , Suyun Li , Wenyu Cao , Cuilan Zhou , Yang Xu","doi":"10.1016/j.bbr.2025.115549","DOIUrl":"10.1016/j.bbr.2025.115549","url":null,"abstract":"<div><div>Epilepsy is a serious neurological disorder, but its underlying cellular and molecular mechanisms remains incomplete. As a member of the bromodomain-containing protein (BCP) family, BRD7 has been implicated in a variety of cellular processes, including chromatin remodeling, transcriptional regulation, and cell cycle progression. However, the role of BRD7 in epilepsy in vivo is still poorly understood. In the present study, we found that pentylenetetrazole (PTZ)-induced epilepsy increased hippocampal BRD7, which was mainly localized in neurons. In addition, the enhanced expression of hippocampal BRD7 was normalized by using the anti-epilepsy drug valproic acid (VPA). Furthermore, we identified that the BRD7 inhibitor BI-9564 could dose dependently alleviated the seizure behavior in PTZ treated mice, which was also validated in pilocarpine mouse model. Mechanistically, the anti-seizure effect of BI- 9564 might be due to its negative-regulation of hippocampal TRPV4 that downregulated neuronal over-excitability. Importantly, BRD7 blockade retained its antiepileptic activity over chronic dosing that was not related to psychomotor or cognitive effects. To our knowledge, these results are the first evidence to demonstrate that BRD7 inhibitor can down-regulate neuronal over-excitation caused by epilepsy possible by regulating TRPV4. Targeting BRD7 through the development of selective inhibitors may lead to disease-modifying therapies that reduce seizure behavior.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"485 ","pages":"Article 115549"},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Mechanisms of Neuroprotection: The Interplay of Klotho, SIRT-1, Nrf2, and HO-1 in Neurological Health

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-20 DOI: 10.1016/j.bbr.2025.115545

Ravi Rana , Ritam Mukherjee , Sidharth Mehan , Zuber khan , Ghanshyam Das Gupta , Acharan S Narula

{"title":"Molecular Mechanisms of Neuroprotection: The Interplay of Klotho, SIRT-1, Nrf2, and HO-1 in Neurological Health","authors":"Ravi Rana , Ritam Mukherjee , Sidharth Mehan , Zuber khan , Ghanshyam Das Gupta , Acharan S Narula","doi":"10.1016/j.bbr.2025.115545","DOIUrl":"10.1016/j.bbr.2025.115545","url":null,"abstract":"<div><div>Neurological disorders significantly impair neuronal function and lead to cognitive and motor deficits. This review manuscript explores the therapeutic potential of key proteins—Klotho, SIRT-1, Nrf2, and HO-1—in combating these disorders. Neurological conditions encompass neurotraumatic, neurodegenerative, and neuropsychiatric diseases, all characterized by neuronal loss and dysfunction. The complex functions of Klotho, an anti-aging protein, and SIRT-1, a histone deacetylase, highlight their roles in neuronal survival and neuroprotection through the enhancement of antioxidant defences and the modulation of stress responses. Nrf2 functions as the principal regulator of the antioxidant response, whereas HO-1 facilitates the control of oxidative stress and the resolution of inflammation. Evidence suggests that the interplay between these proteins facilitates neuroprotection by decreasing oxidative damage and promoting cognitive function. The study emphasises the significance of signalling pathways, particularly the Nrf2/HO-1 axis, which are essential in mitigating oxidative stress and inflammation linked to neurodegenerative disorders. Future therapeutic strategies must consider personalized approaches, innovative drug delivery systems, and early intervention to optimize outcomes. This review provides a comprehensive framework for understanding how targeting these pathways can mitigate the burden of neurological disorders, advancing the development of effective interventions for enhancing brain health.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"485 ","pages":"Article 115545"},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The resting-state brain activity and connectivity mediates the effect of overt narcissism on negative physical self

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-20 DOI: 10.1016/j.bbr.2025.115546

Xiaowei Xie , Linlin Fan , Ximei Chen , Yijun Luo , Hong Chen

{"title":"The resting-state brain activity and connectivity mediates the effect of overt narcissism on negative physical self","authors":"Xiaowei Xie , Linlin Fan , Ximei Chen , Yijun Luo , Hong Chen","doi":"10.1016/j.bbr.2025.115546","DOIUrl":"10.1016/j.bbr.2025.115546","url":null,"abstract":"<div><div>Overt narcissism is a stable personality trait in which individuals maintain a relatively positive self-image through self-improvement. Previous studies have suggested that examining the neurobiological processes behind personality could help to understand the mechanism by which the personality acts as a risk or protective factor. However, there is a lack of research investigating the neural mechanisms underlying the influence of overt narcissism on negative physical self (NPS). This study evaluated the resting state brain activity (fractional amplitude of low-frequency fluctuations, fALFF) and connectivity (functional connectivity, FC) of 1647 college students. Whole brain correlation analysis showed that overt narcissism was positively correlated with fALFF in the left insula, left precentral gyrus (PreCG) and bilateral superior temporal gyrus (STG). Moreover, overt narcissism exhibited a significant positive correlation with the right STG-PreCG connectivity, and also was significantly positively correlated with FC between the left STG and posterior cingulate gyrus, the left orbitofrontal cortex, the right inferior frontal gyrus and the right thalamus. The results of mediating analysis showed that fALFF in the left PreCG and the right STG-PreCG connectivity partially mediated the effects of overt narcissism on general and facial appearance of NPS, respectively. This study constructed a model (i.e., overt narcissism→brain regions/FC→NPS), providing neurobiological evidence for the relationship between overt narcissism and NPS.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"485 ","pages":"Article 115546"},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cecal slurry-induced sepsis in mice impairs cognition and decreases SUMO-2/3 conjugation

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-03-19 DOI: 10.1016/j.bbr.2025.115544

Letícia Yoshitome Queiroz , Luana Nunes Mariot , Ericks Sousa Soares , Carolina Urach Stahler , Gustavo Griebner , Gustavo de Moraes Machado , João M. Gissoni , Jaquelini Betta Canever , Regina Sordi , Helena Cimarosti

{"title":"Cecal slurry-induced sepsis in mice impairs cognition and decreases SUMO-2/3 conjugation","authors":"Letícia Yoshitome Queiroz , Luana Nunes Mariot , Ericks Sousa Soares , Carolina Urach Stahler , Gustavo Griebner , Gustavo de Moraes Machado , João M. Gissoni , Jaquelini Betta Canever , Regina Sordi , Helena Cimarosti","doi":"10.1016/j.bbr.2025.115544","DOIUrl":"10.1016/j.bbr.2025.115544","url":null,"abstract":"<div><div>Sepsis is characterized by multiple organ dysfunction, dysregulation of the response to the infection process, and a high mortality rate in intensive care units. In addition, individuals who overcome sepsis often manifest cognitive deficits associated with neuroinflammation resulting from the entry of pro-inflammatory cytokines into the brain. Post-translational protein modifications, such as SUMOylation, can regulate the expression of pro-inflammatory genes during sepsis. Since SUMO-2/3 can play a role in pathological conditions, our aim was to investigate a potential link between sepsis-induced cognitive decline and SUMOylation by this isoform. Firstly, the cecal slurry model was induced by intraperitoneally injecting male Swiss mice with different volumes of a cecal solution. Following assessment of body temperature, mass and septic scores, the groups that received 300 μL and 350 μL of the cecal solution were selected for the behavioural tests, as they presented signs of sepsis without excessive mortality. Surviving animals were evaluated for cognition/memory and anxious/depressive-like behaviours through the open-field, object recognition, Y-maze, and tail suspension tests. Subsequently, SUMO-2/3 conjugation was determined in samples from the hippocampus and prefrontal cortex by Western blotting. Mice in the septic groups showed decreased locomotor activity, anxious-and depressive-like behaviours, as well as impaired memory. These deficits were accompanied by a decrease in SUMO-2/3 conjugation in the hippocampus and prefrontal cortex at 24 h and 10 days after the induction of the cecal slurry model. Taken together, our findings suggest that SUMOylation is impaired in septic animals and this could be related to the behavioural deficits seen in the surviving mice.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"485 ","pages":"Article 115544"},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0