Behavioural Brain Research最新文献

{"title":"Early stage seronegative autoimmune psychosis","authors":"Imke Amanzada , Caroline Bouter , Dirk Fitzner , Kristina auf dem Brinke , Berend Malchow , Jens Wiltfang , Niels Hansen","doi":"10.1016/j.bbr.2025.115739","DOIUrl":"10.1016/j.bbr.2025.115739","url":null,"abstract":"","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115739"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association of cognitive reserve and frailty with incident Alzheimer's disease and related dementias","authors":"Yu-Ying Zhang ,&nbsp;Bao-Lin Han ,&nbsp;Ling-Zhi Ma ,&nbsp;Liang-Yu Huang ,&nbsp;Hai-Hua Guo ,&nbsp;Shuang-Ling Han ,&nbsp;Yin-Chu Mi ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative,&nbsp;Jia-Yao Liu ,&nbsp;Ze-Hu Sheng ,&nbsp;Lan Tan ,&nbsp;Hui-Fu Wang","doi":"10.1016/j.bbr.2025.115733","DOIUrl":"10.1016/j.bbr.2025.115733","url":null,"abstract":"<div><div>Cognitive reserve and frailty are factors associated with Alzheimer's disease and related dementias (ADRD). However, whether cognitive reserve and frailty interact to influence ADRD has not been explored well. We included 908 participants from the ADNI study. Our results suggested that cognitive reserve interacted with frailty to influence ADRD risk. High cognitive reserve was associated with lower ADRD risk in both non-frail and mildly frail participants (<em>P</em> value &lt; 0.001), but the association was not observed in severely frail participants. Furthermore, mediation analysis showed that cognitive reserve influence dementia risk partly through the modulation of AD biomarkers in non-frail and mildly frail participants. Our study demonstrated that high cognitive reserve decreased the risk of ADRD by modulating AD pathology in non-frail and mildly frail participants.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115733"},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neurocognitive basis of deception: Individual differences of N2-related conflict monitoring in a social deception task","authors":"Fee-Elisabeth Bertram,&nbsp;Anja Leue","doi":"10.1016/j.bbr.2025.115738","DOIUrl":"10.1016/j.bbr.2025.115738","url":null,"abstract":"<div><div>Conflict monitoring was investigated as a neuro-cognitive process of deception. To investigate individual differences of conflict monitoring during a social deception task, we employed the fronto-central N2 component of the electroencephalogram. <em>N</em> = 96 participants (male = 48) reported the trustworthiness or untrustworthiness of previously learned faces in two experimental conditions (affective vs. neutral) either truthfully or deceptively and completed the German BIS/BAS scales and the Conflict Monitoring Questionnaire-44. For an assessment of the robustness of the results, the N2 was quantified using three different quantification methods. Peak-to-peak N2 amplitudes were more negative following untrustworthy vs. trustworthy stimuli regardless of the truthfulness, indicating their sensitivity to negative affect. None of the investigated traits had a significant effect on the individual extent of conflict monitoring. The peak-to-peak amplitude appeared to be most suitable for quantifying the N2 in the examination of conflict monitoring during deception. Results indicated shorter response times and higher correct rates for truthful responses. Since the significance of the Picture type main effect varies with the N2 quantification method, assessing reliability data and examining paradigm parameters could clarify the impact of different N2 quantification approaches on achieving excellent reliability.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115738"},"PeriodicalIF":2.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated, sustained inflammation affects hippocampal dependent learning and neuroinflammation across age and sex","authors":"Marianna B. Frey ,&nbsp;Shabnam Tursunova ,&nbsp;Allison T. Parker ,&nbsp;Lauren L. Williamson","doi":"10.1016/j.bbr.2025.115734","DOIUrl":"10.1016/j.bbr.2025.115734","url":null,"abstract":"<div><div>Brain aging results in alterations of baseline neuroimmune signaling and cognitive function. Here, we characterize hippocampal-dependent cognitive function for two behavioral tasks, the T-maze and context object discrimination (COD), following repeated inflammation with peripheral lipopolysaccharide (LPS) treatment in three age groups. Inflammation affected behavior differently across age groups. Males that received LPS were more likely to complete the T-maze task and select the correct arm compared to other groups. Six-month-old female rats were more successful on the COD task following LPS compared to other ages. Three-month-old rats were impaired by previous LPS treatment, while 12-month-old rats were unable to complete the task at all. However, the molecular mechanisms for these behavioral changes remain unclear. Microglial morphology was altered in 6-month-olds, but interleukin-1β and phosphorylated tau expression decreased within the brain across age. The behavioral improvement in the 6-month-olds following LPS indicates a unique response of their brains to peripheral inflammation and shows a distinct trajectory from young to older adults. Specific mechanisms for these behavioral differences remain unexplored.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115734"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural circuit for non-suicidal self-injury and causal clinical validation","authors":"Shaoyang Wang ,&nbsp;Yue Wu ,&nbsp;Wenjia Wang ,&nbsp;Jiahua Zhang ,&nbsp;Feng Geng ,&nbsp;Qianqian Li ,&nbsp;Guixian Xiao ,&nbsp;Meidan Zu ,&nbsp;Jiajia Nie ,&nbsp;Liangping Ni ,&nbsp;Dai Zhang ,&nbsp;Kunpeng Cheng ,&nbsp;Rui Qin ,&nbsp;Gong-Jun Ji ,&nbsp;Yanghua Tian","doi":"10.1016/j.bbr.2025.115736","DOIUrl":"10.1016/j.bbr.2025.115736","url":null,"abstract":"<div><h3>Background</h3><div>Non-suicidal self-injury (NSSI) refers to the intentional damage inflicted on one's body tissues without the intent to die. This behavior significantly affects individuals' psychological health and social functioning. Given the unclear neural mechanisms of NSSI, this study aimed to explore the neural circuits involved in NSSI to improve and provide alternative treatment options.</div></div><div><h3>Methods</h3><div>This study combined Activation Likelihood Estimation (ALE) with network mapping theory through a systematic literature search, selection, and meta-analysis to define the NSSI circuit. Additionally, a clinical trial of transcranial magnetic stimulation (TMS) treatment guided by neuronavigation was conducted to verify the accuracy of the defined NSSI circuit.</div></div><div><h3>Results</h3><div>The ALE meta-analysis identified a significant difference in the left parahippocampal gyrus (PHG). The NSSI circuit included bilateral PHG and cingulate gyrus, bilateral middle frontal gyrus, middle temporal gyrus, inferior temporal gyrus, parietal lobes, and portions of the cerebellum, occipital lobe, and brainstem. A clinical trial of TMS targeting the NSSI circuit significantly improved NSSI symptoms. Moreover, significant changes were observed in the activity levels of specific brain regions of the NSSI circuit, and were significantly correlated with the improvement of NSSI symptoms.</div></div><div><h3>Conclusions</h3><div>This study successfully explored and validated the NSSI circuit using a targeted treatment. TMS targeting the NSSI circuit significantly improved NSSI symptoms and changed the activity levels of specific brain regions of the NSSI circuit. These findings offer a new perspective for a deeper understanding of the neural mechanisms underlying NSSI and provide a scientific basis for developing new treatment methods.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115736"},"PeriodicalIF":2.6,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D intervention improves recognition memory and reduces hippocampal inflammation in rats submitted to an experimental model of cerebral palsy","authors":"Henrique José Cavalcanti Bezerra Gouveia ,&nbsp;Ana Elisa Toscano ,&nbsp;Márcia Maria da Silva ,&nbsp;Luan Kelwyny Thaywã Marques da Silva ,&nbsp;Mariana de Almeida Cruz Silva ,&nbsp;Osmar Henrique dos Santos-Júnior ,&nbsp;Paula Brielle Pontes Silva ,&nbsp;Eulália Rebeca da Silva Araújo ,&nbsp;Raul Manhães de Castro","doi":"10.1016/j.bbr.2025.115735","DOIUrl":"10.1016/j.bbr.2025.115735","url":null,"abstract":"<div><div>Cerebral Palsy (CP) comprises neurological conditions characterized by abnormalities in movement, body posture, and altered muscle tone. Vitamin D (VitD) is important in bone metabolism and has anti-inflammatory, immune, and neuromodulatory properties. The aim of this study was thus to investigate the effects of VitD supplementation on parameters associated with memory, hippocampal inflammation, and neuronal loss in male and female rats with CP. The experimental model of CP included postnatal anoxia (P0-P1) and sensory-motor restriction (P2-P28). The pups were treated intraperitoneally with vehicle or VitD (5 μg/kg/day) during the first 30 days of postnatal life. The following were assessed: reflex-ontogeny, T-Maze and novel object recognition test (NORT), glial and neuronal responses, and inflammatory markers in the hippocampus. In male pups, CP caused delayed reflex maturation, impaired short- (P31) and long-term (P38) object recognition and spatial memory (P50-P52), reduced neuronal density, increased microglial area and density, and elevated expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Female CP pups showed only delayed reflex maturation, impaired long-term object recognition, and increased microglial area. Intervention with VitD led to an earlier maturation of the righting reflex in males and females with CP, better performance in object recognition in the long term, a reduction in the area and density of microglia, as well as a reduction in the expression of TNF-α and IL-6 in CP males. These results confirm the greater resilience of females to the damage caused by CP and the promising effects of VitD in reducing hippocampal neuroinflammation.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115735"},"PeriodicalIF":2.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a single session of transcranial direct current stimulation on inhibitory control and impulsivity in users with excessive Internet gaming: A double-blind, randomized controlled trial","authors":"Zhuoyan Wu,&nbsp;Liang He,&nbsp;Yuetan Wang,&nbsp;Zhuo Ma,&nbsp;Qiuyan Yao,&nbsp;Xiaobin Ding,&nbsp;Bo Wu","doi":"10.1016/j.bbr.2025.115732","DOIUrl":"10.1016/j.bbr.2025.115732","url":null,"abstract":"<div><div>Excessive Internet gaming has become an increasingly serious public health problem, closely related to changes in cognitive function (especially inhibitory control deficits and increased impulsivity) and related brain regions (such as the dorsolateral prefrontal cortex, DLPFC). As a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS) may improve these cognitive deficits by regulating the activity of DLPFC, but its specific effects and mechanisms in the excessive Internet gaming population still need to be further clarified. This study aims to investigate the regulatory effect of transcranial direct current stimulation (tDCS) on the right dorsolateral prefrontal cortex (rDLPFC) on excessive Internet game usage behavior. Fifty-seven excessive Internet game users were randomly divided into real tDCS stimulation (1.5 mA,20 min) and sham tDCS stimulation. We assessed their degree of impulsivity and inhibitory control of Internet gaming-related distractors before and after stimulation.Comparing pre- and post-stimulation with real versus sham tDCS, measures of inhibitory control (GO/NOGO task) and impulsivity (BIS-11) revealed no significant changes in the sham group. However, real tDCS significantly enhanced inhibitory control (increased total accuracy, decreased NOGO error rate, and prolonged GO reaction time) and significantly reduced impulsivity (decreased BIS-11 total and subscale scores).These results indicate that tDCS stimulating rDLPFC can enhance inhibitory control ability and reduce impulsivity, having a positive impact on excessive Internet gamers.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115732"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic signatures of accelerated aging and immune dysregulation in youth with social anxiety disorder","authors":"Zhijian Song ,&nbsp;Xiaobing Lu ,&nbsp;Jijun Zhu ,&nbsp;Pan Li ,&nbsp;Shenghan Wang ,&nbsp;Shunjie Zhang ,&nbsp;Zhongting Huang ,&nbsp;Fuqiang Cai ,&nbsp;Weixin Liu ,&nbsp;Fei Ling ,&nbsp;Junfang Chen","doi":"10.1016/j.bbr.2025.115729","DOIUrl":"10.1016/j.bbr.2025.115729","url":null,"abstract":"<div><div>Social anxiety disorder (SAD) is a prevalent psychiatric condition with significant psychological and socioeconomic consequences. While its psychological characteristics are well-documented, the underlying molecular mechanisms remain poorly understood, particularly in younger populations. This study investigates the epigenetic basis of SAD by identifying differential DNA methylation sites, pathway enrichment patterns, and tissue-specific expression profiles. Genome-wide methylation analysis revealed nominally significant CpG sites associated with SAD, mapping to genes involved in neurotransmitter release, synaptic function, and immune regulation. Tissue enrichment analysis demonstrated that these genes are preferentially modulated in brain regions critical for emotional and social processing, including the frontal cortex and anterior cingulate cortex. Additionally, individuals with young SAD exhibited significant differences in epigenetic age acceleration and immune cell composition, particularly in natural killer cell counts. Finally, colocalization analysis identified genetic variants that overlap with methylation quantitative trait loci, highlighting potential regulatory relationships between genetic risk factors and epigenetic modifications in SAD. These findings provide new insights into the molecular architecture of SAD in youth, offering potential biomarkers and mechanistic targets for future research and therapeutic development.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115729"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal and ventral striatal dendritic morphology: Effects of life-long complex housing and amphetamine administration","authors":"Bryan Kolb ,&nbsp;Yilin Li ,&nbsp;Terry E. Robinson","doi":"10.1016/j.bbr.2025.115728","DOIUrl":"10.1016/j.bbr.2025.115728","url":null,"abstract":"<div><div>Complex housing is one of the most effective experiences in producing plastic changes in the brain. For example, animals living in complex environments show widespread synaptic changes both in cerebral cortex and the striatum. Similarly, repeatedly treating animals with drugs such as amphetamine also induces changes in prefrontal cortex and the striatum. The purpose of the current study was to determine the effects of life-long housing in a complex environment versus standard laboratory caging and the later effects of amphetamine. Both male and female Long-Evans rats were placed in complex environments for about 110 days, beginning at conception, until adulthood at which time they were administered saline or amphetamine daily (1 mg/kg, IP) for 14 days. A week later the brains were harvested and processed for Golgi-Cox staining to analyze dendritic length, branching, and spine density in prefrontal cortex (areas Cg3 and AID) and Nucleus Accumbens (NAcc). Prolonged enriched housing produced significant synaptic changes in all three measures in all three areas measured, but the effects differed in the two sexes. Amphetamine produced large synaptic changes in Cg3 and NAcc in males but only spine changes in those regions in females. Complex housing did not interact with the later effects of amphetamine administration. Thus, both complex housing and amphetamine can produce a range of synaptic changes depending upon sex and area examined. Furthermore, the effect of complex housing varies depending on the details of when complex housing is begun and how long it lasts.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115728"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Movement-related cortical potential during dual tasks with distinct load levels","authors":"Daisuke Hirano ,&nbsp;Misaki Wada ,&nbsp;Naotoshi Kimura ,&nbsp;Yoshinobu Goto ,&nbsp;Takamichi Taniguchi","doi":"10.1016/j.bbr.2025.115730","DOIUrl":"10.1016/j.bbr.2025.115730","url":null,"abstract":"<div><div>We investigated movement-related cortical potential (MRCP) during dual-task performance under different levels of secondary task load. This study included 20 healthy young, right-footed adults. MRCPs were measured under three conditions. The single task (ST) involved internal-paced dorsiflexion of the right ankle joint, whereas in the simple dual task (DT-S) and complex dual task (DT-C), participants engaged in the ST along with a visual number counting and memorizing task, with varying levels of cognitive load. These conditions represented no-, low-, and high-load divided attention tasks, respectively. Although the coefficient of variation (CV) in movement interval was higher during DT-C compared to ST and DT-S, the negative peak amplitude of MRCPs, recorded from the Cz electrode using the international 10/20 system, was lower in DT-S and DT-C compared to ST. Although no significant differences in CV were observed, DT-S resulted in a significant decrease in MRCP amplitude. Our findings indicate that MRCPs may serve as a biomarker for assessing divided attention capacity during dual-task performance, even in the absence of observable differences in task performance. These results suggest that the MRCP amplitude is an indicator of supplementary motor area activation, highlighting the crucial role of attention division in movement preparation and execution when performing dual tasks.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"494 ","pages":"Article 115730"},"PeriodicalIF":2.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}