Behavioural Brain Research最新文献

{"title":"Evaluating alpha-synuclein proteinopathy and consequences for birdsong in zebra finch basal ganglia area X","authors":"Reed T. Bjork ,&nbsp;Famesh Z. Patel ,&nbsp;Madeleine S. Daly ,&nbsp;Julie E. Miller","doi":"10.1016/j.bbr.2025.115698","DOIUrl":"10.1016/j.bbr.2025.115698","url":null,"abstract":"<div><div>Lewy body pathology is a major hallmark of Parkinson’s Disease (PD) and other dementias. The process of Lewy body formation is largely driven by the aggregation of alpha-synuclein (αsyn), an abundant presynaptic chaperone protein that has been shown to propagate between neurons when misfolded. Preclinical animal models inducing αsyn aggregation in the brain have demonstrated a range of behavioral consequences, though studies connecting behavioral changes to specific features of pathology are lacking. Considering vocal impairment manifests early in individuals with PD and fails to resolve upon dopamine replacement, we examined the effect of αsyn proteinopathy on birdsong in adult male zebra finches to investigate these early mechanisms of PD-related vocal dysfunction. In this study, we describe a novel tool for measuring αsyn expression called the Border Expression Ratio (BER) based on the discrete physiological distribution of αsyn surrounding basal ganglia song center, Area X. Following overexpression of human αsyn in Area X using bilateral injections of adeno-associated virus, we show that BER can be used to measure regional αsyn proteinopathy, revealing a positive correlation between right hemisphere pathology and a reduction in the variation of harmonic syllable duration. Finally, we provide evidence of serine 129 phosphorylation—a biomarker for aggregated αsyn—in Area X and cortical song nucleus LMAN of αsyn-overexpressing finches, despite this residue not being conserved in zebra finch αsyn, indicating modification of the human transgene. Together, these findings provide a framework for future analyses investigating αsyn propagation over time and the effects on vocal behavior.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115698"},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The decision-making and outcome evaluation processes in the Stag Hunt Game: Evidence from neural electrophysiology","authors":"Xianjia Wang ,&nbsp;Wei Cui","doi":"10.1016/j.bbr.2025.115700","DOIUrl":"10.1016/j.bbr.2025.115700","url":null,"abstract":"<div><div>Cooperative behavior is widespread in human social interactions and helps to address social dilemma issues. The Stag Hunt Game is a classic model of social dilemmas, with no studies so far exploring the neural mechanisms behind individual cooperation in this context. To investigate the temporal dynamics of brain processing underlying individual decision-making behavior in social dilemmas, we recorded EEG data from 35 participants during a one-time, two-player Stag Hunt Game and analyzed the data using event-related potential (ERP) and event-related oscillation (ERO) techniques. The results showed that, in the decision-making phase of the game, choosing cooperation induced a smaller P2 amplitude, a larger P3 amplitude, and reduced theta band oscillations compared to choosing defection. In the outcome evaluation phase, loss feedback generated a more negative FRN amplitude, a smaller P300 amplitude, and reduced delta oscillations compared to gain feedback. This study provides preliminary electrophysiological evidence for understanding the dynamic brain processing and neural oscillatory characteristics of human cooperative behavior in the Stag Hunt Game.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115700"},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methamphetamine-induced cognitive impairment: Evaluation of amyloid beta 40 and phosphorylated tau protein 217 in male users","authors":"Mushtaq T. Abood,&nbsp;Mustafa Taha Mohammed","doi":"10.1016/j.bbr.2025.115701","DOIUrl":"10.1016/j.bbr.2025.115701","url":null,"abstract":"<div><div>Methamphetamine (METH) addiction is one of the most illegal substances use disorder worldwide, resulting in social, medical, and psychological consequences. This stimulant of the central nervous system (CNS) has been linked with different physiological effects that lead to the onset of multiple health disorders. This study aimed to investigate cognitive impairment in individuals with METH addiction by analyzing levels of amyloid β 40 (Aβ40) and phosphorylated tau protein at threonine 217 (p-tau 217), as key biomarkers associated with neurodegeneration. Two groups of adult males were assigned in this study, one containing 75 males with no previous history of addiction, non-medical use of any type of drugs, and no history of neurodegenerative diseases. The other group contained 75 males confirmed with METH addiction (1–10 years), Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Among the METH group, 44 % exhibited cognitive impairment based on these assessments. The levels of Amβ 40 and p-tau 217 protein increased significantly (<em>p</em> &lt; 0.001) in individuals with METH addiction compared to non-addicts’ group. Also, Amβ 40 and p-tau 217 protein were correlated positively (r = 0.443, <em>p</em> &lt; 0.001), as well as p-tau 217 and albumin (r = 0.346, <em>p</em> = 0.002). Moreover, Amβ 40 has shown significant impact as risk factor for cognitive impairment in individuals with METH addiction with OR of 1.074 (1.035–1.115 95 % CI). Thus, abusing METH may stimulate dysfunction in the memory, resulting in elevation of Amβ 40 and p-tau 217 protein which leads to hypomnesia, and ultimately may increase the risk of neurodegenerative pathology.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115701"},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of quercetin on motor impairments and anxiety-like behaviors in a rat model of Parkinson’s disease","authors":"Maryam Yousefi ,&nbsp;Mohammad Ali Mirshekar ,&nbsp;Maryam Afsharfar ,&nbsp;Saeideh Arabmoazzen ,&nbsp;Elham Haghparast","doi":"10.1016/j.bbr.2025.115692","DOIUrl":"10.1016/j.bbr.2025.115692","url":null,"abstract":"<div><div>Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments such as bradykinesia and rigidity, and non-motor deficits including anxiety. These phenomena are closely associated with underlying pathological processes including oxidative stress(OS) and mitochondrial dysfunction that arise from the degeneration of dopaminergic neurons in the substantia nigra. Recent studies have shown that flavonoids like quercetin have neuroprotective effects through antioxidant and anti-inflammatory properties. In this study, we aimed to evaluate the impact of quercetin on motor function, anxiety-like behaviors, and Interleukin-6 (IL-6) levels in hippocampal dentate gyrus tissue in a rat model of PD induced by 6-hydroxydopamine (6-OHDA) and examine the behavioral findings with the use of two doses (10 and 25 mg/kg) of quercetin. Forty male Wistar rats were divided into five groups: control, sham, Parkinson's, and two quercetin-treated PD groups (10 and 25 mg/kg), and 6-OHDA (8 μg/3 μl) was injected into the left medial forebrain bundle (MFB) in three of them to induce PD. The behavioral assessments evaluated motor function and anxiety-like behaviors, including apomorphine-induced rotation, rotarod, wire hanging, elevated plus maze, and open field tests. Our results indicate that quercetin treatment significantly reduced apomorphine-induced rotations, supporting the results of rotarod and wire hanging tests, improved motor coordination, with the 25 mg/kg dose showing greater efficacy. Quercetin also alleviated anxiety-like behaviors in a dose-dependent manner based on the results of the elevated plus maze and open field tests. In addition, the results showed a significant elevation of IL-6 in the hippocampus of PD rats compared to the control group, and quercetin treatment can reduce its levels, though the levels remained higher than in the sham and control groups. These findings suggest that quercetin ameliorates both motor and anxiety-like deficits in a 6-OHDA rat model of Parkinson’s disease, potentially through modulation of hippocampal neuro-inflammation, highlighting its promise as a multi-target therapeutic agent in PD.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115692"},"PeriodicalIF":2.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Litter reduction-induced obesity reduces masticatory performance and SERT expression in the mesencephalic trigeminal nucleus","authors":"Cynthya Myllena Martins Silva ,&nbsp;Isabeli Lins Pinheiro ,&nbsp;Renata Emmanuele Assunção Santos ,&nbsp;Fernanda Carolina Ribeiro Dias ,&nbsp;Nilian Cerqueira Azevêdo ,&nbsp;Lívia Maria de Lima Leoncio ,&nbsp;Sandra Lopes de Sousa ,&nbsp;Lígia Cristina Monteiro Galindo ,&nbsp;Raquel da Silva Aragão ,&nbsp;Kelli Nogueira Ferraz-Pereira","doi":"10.1016/j.bbr.2025.115694","DOIUrl":"10.1016/j.bbr.2025.115694","url":null,"abstract":"<div><h3>Introduction</h3><div>Studies associate obesity with poorer masticatory performance. Obese individuals have larger bite size, use fewer masticatory sequences, and chew faster, contributing to higher food intake. The mesencephalic trigeminal nucleus facilitates the transmission of sensory input from the oral cavity to coordinate orofacial movements during chewing and swallowing. The serotonin transporter (SERT) acts on serotonergic neurotransmission control and correlates with obesity parameters.</div></div><div><h3>Objective</h3><div>To evaluate the effect of obesity induced by litter size reduction on somatic and masticatory performance and serotonin transporter immunoreactivity in the mesencephalic trigeminal nucleus.</div></div><div><h3>Methods</h3><div>Wistar rats were distributed into a control group (CL; 9 pups per dam; n = 13) and a small litter group (SL; 3 pups per dam; n = 13), analyzing their body weight, brown and white adipose tissue weight, food intake during mastication, masticatory jaw movements, and serotonin transporter immunohistochemistry.</div></div><div><h3>Results</h3><div>The overfed group had greater body weight from postnatal day 14 onwards; greater food consumption through chewing, and fewer chewing sequences and cycles on postnatal day 22; and greater amounts of inguinal, epididymal, mesenteric, retroperitoneal, and brown fat on postnatal day 30. Overfed animals had longer chewing sequences and lower chewing rates; they also had lower expression of SERT-IR, larger diameter of neurons and lower neuronal density in the mesencephalic trigeminal nucleus.</div></div><div><h3>Conclusion</h3><div>Obesity induced by neonatal overnutrition leads to decreased SERT expression in the mesencephalic trigeminal nucleus, leading to less rhythmic chewing activity and greater food consumption during chewing. These findings show the importance of the relationship between obesity, chewing, and SERT expression.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115694"},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental caffeine triggers oxidative stress and behavioral changes in Cyprinus carpio: Insights into neurotoxicity","authors":"Idalia Casas-Hinojosa ,&nbsp;Leobardo Manuel Gómez-Oliván ,&nbsp;Sandra García-Medina ,&nbsp;Luis Alberto Orozco-Hernández ,&nbsp;José Roberto Jerónimo-Juárez ,&nbsp;Diana Belén Onofre-Camarena ,&nbsp;Karina Elisa Rosales-Pérez ,&nbsp;Veronica Margarita Gutierrez-Noya ,&nbsp;José Manuel Orozco-Hernández ,&nbsp;Gustavo Axel Elizalde-Velázquez ,&nbsp;Marcela Galar-Martínez ,&nbsp;María Dolores Hernández-Navarro ,&nbsp;Octavio Dublán-García ,&nbsp;Hariz Islas-Flores","doi":"10.1016/j.bbr.2025.115695","DOIUrl":"10.1016/j.bbr.2025.115695","url":null,"abstract":"<div><div>Caffeine (CAF) is categorized as a central nervous system (CNS) stimulant, with effects varying based on factors like species, exposure duration, and dosage. The CNS regulates vital physiological processes and is notably sensitive to environmental pollutants, particularly oxidative stress due to its high lipid content. This study investigates the impact of CAF a known CNS stimulant, on juvenile <em>Cyprinus carpio</em> at various exposure levels (0, 500, 1250, 1750 and 2500 ng/L). Employing a holistic approach, we assessed the oxidative stress markers such as lipid peroxidation (LPX), hydroperoxides content (HPC), protein carbonyl content (PCC) and antioxidant responses superoxide dismutase (SOD) and catalase (CAT), alongside AChsterase (AChE) activity, behavioral patterns (Novel Tank Test, Dark &amp; Light Test), histological changes (H&amp;E staining), and gene expression (<em>adenosine receptor A1</em>, <em>adenosine receptor A2A, serca</em>, <em>ryr, i3pr</em>). Our findings indicate that increasing CAF concentrations correlate with heightened oxidative and antioxidant biomarker levels in the carp brain. Specifically, AChE activity diminished, reflecting neurotoxicity. Behaviorally, CAF displayed a biphasic influence: at lower concentrations (500 ng/L), it promoted locomotion and reduced anxiety, whereas at concentrations above 2500 ng/L, it suppressed locomotor activity and heightened anxiety-like behaviors. Notably, the highest concentration (2500 ng/L) resulted in significant histopathological changes, with a 45.9 % incidence of pathological alterations, predominantly vacuolization in the telencephalon and optic tectum. Gene expression analysis revealed an upregulation of <em>adenosine receptor A1</em> and <em>adenosine receptor A2A</em>, indicating variations in the CAF mechanism based on receptor interaction. Additionally, there was a positive regulation of genes involved in Ca^2 + signaling (<em>serca, ryr, i3pr</em>), crucial for cellular homeostasis and implicated in cellular neoplasia’s. The study conclusively demonstrates that while low CAF doses can have beneficial effects on mobility, higher doses lead to pronounced neurotoxicity, indicated by oxidative stress, enzymatic inhibition, anxiety-like behavior, cerebral histopathology, and gene expression dysregulation. These findings provide critical insights into the dose-dependent neurotoxic effects of environmental CAF exposure in aquatic vertebrates.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115695"},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic and endocrine dysfunctions in traumatic brain injury: Implications for cognitive recovery and therapeutic strategies","authors":"Jigar Manilal Haria ,&nbsp;Naveen Kumar Singh ,&nbsp;Jayballabh Kumar ,&nbsp;Sanjeev Kumar Jain ,&nbsp;DattaSai Pamidimarri","doi":"10.1016/j.bbr.2025.115697","DOIUrl":"10.1016/j.bbr.2025.115697","url":null,"abstract":"<div><div>Traumatic brain injury (TBI) triggers a chain reaction of intricate metabolic abnormalities, sometimes leading to ongoing cognitive deficits. These abnormalities comprise dysregulation in trace element homeostasis, disrupted neurotransmitter modulation, increased lipid peroxidation, compromised glucose metabolism, and organ-specific metabolic changes. Most recent studies suggest that metabolic abnormalities are the root cause of cognitive decline in post-traumatic stress disorder. Restoring metabolic balance through therapeutic modalities, such as antioxidant therapy to combat lipid peroxidation, glucose modulators to normalise cerebral energy metabolism, and trace element supplementation, shows promise. Furthermore, increasingly understood as important determinant of long-term neurocognitive outcomes are endocrine dysfunctions, especially post-traumatic hypopituitarism and growth hormone deficiency (GHD). Growth hormone replacement therapy has been shown to improve cognitive function and overall recovery. Biomarkers such as insulin-like growth factor-1 (IGF-1), neuroinflammatory cytokines (IL-6 and TNF-α), and oxidative stress markers (like malondialdehyde) can facilitate early diagnosis, which may allow for targeted and timely intervention. This review is metabolism-oriented, biomarker-guided therapeutic approaches to improve neurocognitive recovery and patient quality of life, highlighting the critical role that metabolic and endocrine abnormalities play in post-TBI cognitive impairment.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115697"},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An EEG-based imagined speech recognition using CSP-TP feature fusion for enhanced BCI communication","authors":"Haresh M.V.,&nbsp;Kannadasan K.,&nbsp;Shameedha Begum B.","doi":"10.1016/j.bbr.2025.115652","DOIUrl":"10.1016/j.bbr.2025.115652","url":null,"abstract":"<div><h3>Background:</h3><div>Imagined speech has emerged as a promising paradigm for intuitive control of brain-computer interface (BCI)-based communication systems, providing a means of communication for individuals with severe brain disabilities. In this work, a non-invasive electroencephalogram (EEG)-based automated imagined speech recognition model was proposed to assist communication to convey the individual’s intentions or commands. The proposed approach uses Common Spatial Patterns (CSP) and Temporal Patterns (TP) for feature extraction, followed by feature fusion to capture both spatial and temporal dynamics in EEG signals. This fusion of the CSP and TP domains enhances the discriminative power of the extracted features, leading to improved classification accuracy.</div></div><div><h3>New method:</h3><div>An EEG data set was collected from 15 subjects while performing an imagined speech task with a set of ten words that are more suitable for paralyzed patients. The EEG signals were preprocessed and a set of statistical characteristics was extracted from the fused CSP and TP domains. Spectral analysis of the signals was performed with respect to ten imagined words to identify the underlying patterns in EEG. Machine learning models, including Linear Discriminant Analysis (LDA), Random Forest (RF), Support Vector Machine (SVM), and Logistic Regression (LR), were employed for pairwise and multiclass classification.</div></div><div><h3>Results:</h3><div>The proposed model achieved average classification accuracies of 83.83% <span><math><mo>±</mo></math></span> 5.94 and 64.58% <span><math><mo>±</mo></math></span> 10.43 and maximum accuracies of 97.78% and 79.22% for pairwise and multiclass classification, respectively. These results demonstrate the effectiveness of the CSP-TP feature fusion approach, outperforming existing state-of-the-art methods in imagined speech recognition.</div></div><div><h3>Conclusion:</h3><div>The findings suggest that EEG-based automatic imagined speech recognition (AISR) using CSP and TP techniques has significant potential for use in BCI-based assistive technologies, offering a more natural and intuitive means of communication for individuals with severe communication limitations.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115652"},"PeriodicalIF":2.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effects of orexin receptor 1 antagonism on decision making under uncertainty","authors":"Jeremy A. Metha ,&nbsp;Mathilde Bertheau ,&nbsp;Carsten Murawski ,&nbsp;Daniel Hoyer ,&nbsp;Laura H. Jacobson","doi":"10.1016/j.bbr.2025.115691","DOIUrl":"10.1016/j.bbr.2025.115691","url":null,"abstract":"<div><div>Orexins/hypocretins are neuropeptides produced by several thousand neurons in the lateral hypothalamus. They project widely through the central nervous system where they release orexins which bind to two regionally selective G-protein coupled receptors: OX₁R and OX₂R. Orexins are well known as regulators of the sleep/wake cycle, however, recent investigations into orexinergic modulation of feeding and drug-seeking behaviour suggest they also play a role in reward processing and decision making. In the present study, we investigated the effects of OX₁R antagonism on goal-directed decision making using an operant probabilistic reversal learning (PRL) task. 44 male C57/BL6 mice were dosed daily with an OX₁R selective antagonist (1-SORA-51, 45 mg/kg) or vehicle (20 % w/v TPGS) while performing a PRL task consisting of 5 sessions on 5 consecutive days of probabilistic discrimination learning, followed by 5 sessions of reversal learning, both on and off drug, in a crossover design. Behaviours were then analysed within a reinforcement learning framework. Mice treated with 1-SORA-51 show a significant decrease in learning both initial and reversed reward contingencies, mediated largely through learning from positive outcomes. 1-SORA-51 also increased exploratory behaviours, both during learning and after reward contingencies had been learned. The findings suggest that OX₁R signalling plays multiple roles in decision making in both learning and reward processing, largely by impacting the positive reward domain. As such, OX₁R antagonists may be of therapeutic interest for improving abnormal reward processing and explore-exploit behaviours, such as the heightened sensitivity to drug cues and reduced responses to natural rewards, or heightened delay discounting as observed in people with substance use disorders.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115691"},"PeriodicalIF":2.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Effects of High-Intensity Interval Training (HIIT) on miR-29c and miR-146a expression in the hippocampus of streptozotocin-induced diabetic rats\" [Behav. Brain Res. 489 (2025) 115632].","authors":"Mehdi Soltani Ichi, Fatemeh Shabkhiz, Mohammadreza Kordi","doi":"10.1016/j.bbr.2025.115687","DOIUrl":"https://doi.org/10.1016/j.bbr.2025.115687","url":null,"abstract":"","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115687"},"PeriodicalIF":2.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}