Behavioural Brain Research最新文献_第3页

Corrigendum to "Effects of High-Intensity Interval Training (HIIT) on miR-29c and miR-146a expression in the hippocampus of streptozotocin-induced diabetic rats" [Behav. Brain Res. 489 (2025) 115632]. “高强度间歇训练（HIIT）对链脲霉素诱导的糖尿病大鼠海马中miR-29c和miR-146a表达的影响”的更正[Behav。中国生物医学工程学报，2015(5):344 - 349。

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-06-05 DOI: 10.1016/j.bbr.2025.115687

Mehdi Soltani Ichi, Fatemeh Shabkhiz, Mohammadreza Kordi

引用次数: 0

Perceptual regulation of ideal body shape in young women with body shame: An ERP study of cognitive reappraisal 年轻女性身体羞耻感对理想体型的知觉调节：认知重评价的ERP研究

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-06-04 DOI: 10.1016/j.bbr.2025.115690

Zhennan Liu , Yinying Hu , Haoyue Qian , Xiangping Gao

{"title":"Perceptual regulation of ideal body shape in young women with body shame: An ERP study of cognitive reappraisal","authors":"Zhennan Liu , Yinying Hu , Haoyue Qian , Xiangping Gao","doi":"10.1016/j.bbr.2025.115690","DOIUrl":"10.1016/j.bbr.2025.115690","url":null,"abstract":"<div><div>Media portrayals of idealized bodies reinforce appearance-based comparisons, leading to body dissatisfaction and associated cognitive and emotional disturbances among women. Integrating objectification theory and emotion regulation frameworks, this event-related potential (ERP) study examined how cognitive reappraisal affects attractiveness evaluations and attentional biases toward idealized bodies among women experiencing body shame. Fifty-one women completed body shame assessments and were randomly assigned to cognitive reappraisal group (CRG, n = 25) or control group (CG, n = 26). A mixed factorial design (Group: CRG vs. CG × Stimulus Type: Ideal vs. Neutral Body × Time: Pre-test vs. Post-test) assessed attractiveness ratings and electroencephalographic (EEG) responses before and after reappraisal. The cognitive reappraisal group received instructions between pre- and post-tests; all participants then completed an attention bias task with EEG recording. Behavioral results revealed that cognitive reappraisal significantly reduced attractiveness ratings of idealized bodies and altered attentional biases. Importantly, mediation analyses indicated that cognitive reappraisal mediated the relationship between body shame and attentional biases. ERP analyses indicated cognitive reappraisal increased late positive potential (LPP) amplitudes during evaluation of idealized bodies. Additionally, cognitive reappraisal modulated early attentional N2 amplitudes, predicted by reappraisal-induced LPP changes. Findings suggest cognitive reappraisal regulates perceptions of idealized bodies in body-shamed women via prefrontal cortical mechanisms, with LPP and N2 as key neural markers.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115690"},"PeriodicalIF":2.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of different training intensities on Orexin-1 receptor protein expression in the nucleus accumbens and physical activity drive in male wistar rats 不同训练强度对雄性wistar大鼠伏隔核Orexin-1受体蛋白表达及运动驱力的影响

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-06-03 DOI: 10.1016/j.bbr.2025.115686

Zahra Zare , Shaghayegh Modaberi , Abbas Haghparast , Rana Fayazmilani

{"title":"The effect of different training intensities on Orexin-1 receptor protein expression in the nucleus accumbens and physical activity drive in male wistar rats","authors":"Zahra Zare , Shaghayegh Modaberi , Abbas Haghparast , Rana Fayazmilani","doi":"10.1016/j.bbr.2025.115686","DOIUrl":"10.1016/j.bbr.2025.115686","url":null,"abstract":"<div><h3>Aim</h3><div>An active lifestyle promotes both physical and mental health due to the release of endorphins, dopamine, and other neuropeptides. The orexinergic pathway might regulate physical activity. This study examined how continuous training (CT) and high-intensity interval training (HIIT) of equal volume influence the orexin-1 receptor expression in the nucleus accumbens and voluntary physical activity in male Wistar rats.</div></div><div><h3>Methods</h3><div>Thirty-three eight-week-old male Wistar rats were randomly divided into three groups: C (n = 11), CT (n = 11), and HIIT (n = 11). After an 8-week training period, each group was further divided into two subgroups for brain tissue analysis (n = 4) and voluntary physical activity on a running wheel (n = 7). In the brain tissue analysis, the NAc was dissected using a matrix, and orexin-1 receptor expression was measured using the Western blot method. The subjects' physical activity was recorded in running wheel cages for one week. Data analysis was performed using Graph Pad software.</div></div><div><h3>Key findings</h3><div>The findings showed that both training groups significantly decreased orexin1 receptor expression (p < 0.05) and covered a significantly greater distance on the voluntary running wheel after the training period (p < 0.05). Although the CT group showed significantly better adaptation in grip strength and the HIIT group in maximum speed (p < 0.05), no significant differences were observed in other variables.</div></div><div><h3>Significance</h3><div>This study highlights the critical role of the orexin-1 receptor in regulating motivated behaviors related to physical activity, revealing a significant relationship between its expression and exercise motivation. These results call for additional research to explore how variations in orexin-1 receptor levels influence exercise behavior.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115686"},"PeriodicalIF":2.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YAP/TAZ in the nervous system: Key regulatory and therapeutic implications in neurological disorders 神经系统中的YAP/TAZ：神经系统疾病的关键调控和治疗意义

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-06-03 DOI: 10.1016/j.bbr.2025.115672

Jia-Xin Luo , Dong-Mei Wang , Zhao Ran , Mei-Hong Lu

{"title":"YAP/TAZ in the nervous system: Key regulatory and therapeutic implications in neurological disorders","authors":"Jia-Xin Luo , Dong-Mei Wang , Zhao Ran , Mei-Hong Lu","doi":"10.1016/j.bbr.2025.115672","DOIUrl":"10.1016/j.bbr.2025.115672","url":null,"abstract":"<div><div>In recent years, an increasing number of studies have highlighted YAP/TAZ, the downstream effectors of the Hippo pathway, as promising therapeutic targets for various neurological diseases. Although YAP/TAZ signaling pathway involves multiple complex cascades of signal transduction, their specific functions across various cell types and microenvironments remain inadequately understood. Particularly in the nervous system, our comprehension of how YAP/TAZ regulates the physiological activities of diverse neural cell types, and thereby influences the onset and progression of neurological diseases, is still limited. This review investigates YAP/TAZ's function and regulation, summarizing evidence that linking them to essential regulatory processes within the nervous system. It analyzes their roles across various neuronal cell types and explores their interactions with multiple signaling pathways. Furthermore, the review details the involvement of YAP/TAZ in a range of neurological disorders, emphasizing their potential as crucial mediators in these conditions. These insights point to potential therapeutic strategies that target YAP/TAZ for the treatment of neurological diseases.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115672"},"PeriodicalIF":2.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Suok ‘ropewalking’ test of rodent anxiety and sensorimotor disintegration: А 20-year summary of its application in neuroscience research 啮齿动物焦虑和感觉运动解体的Suok“绳索行走”测试：А其在神经科学研究中的应用20年总结。

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-06-02 DOI: 10.1016/j.bbr.2025.115677

Vyacheslav D. Riga , Alisa E. Makhortykh , David S. Galstyan , Murilo S. de Abreu , Allan V. Kalueff

引用次数: 0

Effects of intracerebroventricular lipopolysaccharide administration on behavioral, neurochemical, and neurogenomic responses in adult zebrafish 脑室内脂多糖对成年斑马鱼行为、神经化学和神经基因组反应的影响。

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-06-02 DOI: 10.1016/j.bbr.2025.115676

Nikita P. Ilyin , David S. Galstyan , Anastasia E. Zolotova , Nikita I. Golushko , Varvara N. Tolkunova , Saklakova Daryna , Daniil Martynov , Kirill V. Apukhtin , Adam Michael Stewart , Murilo S. de Abreu , Allan V. Kalueff

{"title":"Effects of intracerebroventricular lipopolysaccharide administration on behavioral, neurochemical, and neurogenomic responses in adult zebrafish","authors":"Nikita P. Ilyin , David S. Galstyan , Anastasia E. Zolotova , Nikita I. Golushko , Varvara N. Tolkunova , Saklakova Daryna , Daniil Martynov , Kirill V. Apukhtin , Adam Michael Stewart , Murilo S. de Abreu , Allan V. Kalueff","doi":"10.1016/j.bbr.2025.115676","DOIUrl":"10.1016/j.bbr.2025.115676","url":null,"abstract":"<div><div>Neuroinflammation is a common trigger of multiple neuropsychiatric disorders. Lipopolysaccharide (LPS) administration is widely used to induce systemic and neural inflammation in various in vivo animal models. Complementing rodent studies, the zebrafish emerges as a powerful model organism for studying complex neurobehavioral consequences of neuroinflammation. Here, adult fish received an intracerebroventricular injection of LPS and were assessed behaviorally in the novel tank, the zebrafish tail immobilization (ZTI) and the Y-maze tests for locomotor, affective and cognitive responses. We also performed neurochemical and neurogenomic profiling of zebrafish to assess their brain monoamine levels and the expression of selected cytokine-related genes. Overall, LPS-treated zebrafish showed hypolocomotion in the novel tank test, reduced spontaneous alternation in the Y-maze and higher ZTI test immobility, suggesting affective and cognitive deficits, accompanied by elevated serotonin turnover and upregulated pro-inflammatory (<em>Il1b, tnf</em>) and anti-inflammatory (<em>il10</em>) cytokine genes. Collectively, these findings parallel rich rodent evidence of central LPS effects, and support zebrafish as a valuable model system for probing the interplay between neuroinflammation and psychiatric disorders, with a specific focus on evolutionarily conserved, shared mechanisms of CNS pathogenesis.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115676"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blocking the NR2B in the hippocampal dentate gyrus reduced the spatial memory deficits and apoptosis through the PERK-CHOP pathway in a rat model of sporadic Alzheimer's disease 阻断海马齿状回NR2B通过PERK-CHOP通路减少散发性阿尔茨海默病大鼠模型的空间记忆缺陷和细胞凋亡

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-06-02 DOI: 10.1016/j.bbr.2025.115685

Zihan Zhang , Shuhan Guo , Mingyue Li , Kuiyang Shao , Bin Xiao , Qinghua Jin

{"title":"Blocking the NR2B in the hippocampal dentate gyrus reduced the spatial memory deficits and apoptosis through the PERK-CHOP pathway in a rat model of sporadic Alzheimer's disease","authors":"Zihan Zhang , Shuhan Guo , Mingyue Li , Kuiyang Shao , Bin Xiao , Qinghua Jin","doi":"10.1016/j.bbr.2025.115685","DOIUrl":"10.1016/j.bbr.2025.115685","url":null,"abstract":"<div><div>The hippocampal dentate gyrus (DG) integrates multiple sensory inputs and encodes spatial memory. DG-dependent spatial memory deficits have been observed in early Alzheimer's disease (AD). Our previous study demonstrated that glutamate (Glu)-mediated excitotoxicity contributes to spatial learning and memory impairment in AD. It has been reported that the N-methyl-D-aspartic acid receptor (NMDAR) 2B subunit (NR2B) is predominantly localized to extrasynaptic sites, where it is associated with Ca²⁺ neurotoxicity and neuronal loss. However, the specific contribution of NR2B-mediated excitotoxicity to DG neuronal apoptosis and memory impairment in sporadic AD (sAD) remains unclear. In this study, we established a sAD rat model through a single intraventricular injection of streptozotocin combined with intraperitoneal injection of D-galactose. We investigated the role of NR2B in DG apoptosis and spatial learning and memory by microinjecting ifenprodil, an NR2B antagonist, into the hippocampal DG. Behavioral tests showed increased escape latency, reduced swimming distance in the target quadrant and platform crossings, and the significantly increased expression of cleaved caspase-3, PARP, and p-PERK, p-eIF2α, and CHOP in the sAD rats. Microinjection of ifenprodil into the DG markedly inhibited the levels of p-PERK, p-eIF2α, CHOP, cleaved caspase-3, PARP, and neuronal apoptosis in the DG, while also ameliorating the spatial learning and memory impairments in sAD rats. These results suggest that NR2B in the hippocampal DG is associated with neuronal apoptosis <em>via</em> the PERK-CHOP pathway and contributes to the spatial learning and memory deficits observed in sAD rats.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115685"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the structural neuroimaging signature of apathy in Parkinson's disease 研究帕金森病冷漠的结构神经影像学特征。

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-05-30 DOI: 10.1016/j.bbr.2025.115664

Thiago Macedo e Cordeiro , Benson Mwangi , Eduarda Xavier Carreira , Ana Carolina de Almeida Prado , Fabíola Tavares , Francisco Cardoso , Antônio Jaeger , Leonardo Cruz de Souza , Erin Furr Stimming , Antônio Lucio Teixeira , Natalia Pessoa Rocha

{"title":"Investigating the structural neuroimaging signature of apathy in Parkinson's disease","authors":"Thiago Macedo e Cordeiro , Benson Mwangi , Eduarda Xavier Carreira , Ana Carolina de Almeida Prado , Fabíola Tavares , Francisco Cardoso , Antônio Jaeger , Leonardo Cruz de Souza , Erin Furr Stimming , Antônio Lucio Teixeira , Natalia Pessoa Rocha","doi":"10.1016/j.bbr.2025.115664","DOIUrl":"10.1016/j.bbr.2025.115664","url":null,"abstract":"<div><h3>Background</h3><div>Apathy is a common syndrome in up to 70 % of people with Parkinson's disease (PD), and it tends to worsen as the disease progresses. It is an independent predictor of poor clinical outcomes and reduced quality of life in PD patients. Apathy is linked to lower adherence to treatment and has a significant impact on the emotional well-being of caregivers. Identifying the neural basis of PD-related apathy is vital for determining treatment targets and prognostic biomarkers.</div></div><div><h3>Objectives</h3><div>To define the neuroanatomical basis of apathy in PD compared to controls.</div></div><div><h3>Methods</h3><div>Cross-sectional study including 24 patients with PD and 25 controls. Participants underwent a comprehensive clinical assessment and a structural magnetic resonance imaging (MRI) protocol. Elastic Net regression models with clinical, demographic, volumetric, and cortical thickness data were used to identify key predictors of the apathy scale (AS) scores in both groups.</div></div><div><h3>Results</h3><div>Significant neuroanatomical predictors of the AS scores were identified, with distinct predictors for PD patients and controls. The best predictor of AS scores in the PD group was the cortical thickness of the right temporal pole, while the best predictor in the control group was the volume of the mid-anterior corpus callosum. The models revealed differences in the predictors' strength and direction between groups.</div></div><div><h3>Conclusions</h3><div>The study underscores the distinct neuroanatomical correlates of apathy in PD, offering insights into the condition's underlying mechanisms. This contributes to the broader understanding of PD-related apathy and highlights potential areas for therapeutic intervention.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115664"},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting brain health and resilience: The effect of three types of acute exercise on affect, brain-derived neurotrophic factor and heart rate variability 促进大脑健康和恢复力：三种急性运动对情绪、脑源性神经营养因子和心率变异性的影响

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-05-30 DOI: 10.1016/j.bbr.2025.115675

Thomas Rawliuk , Mikal Thrones , Dean M. Cordingley , Stephen M. Cornish , Steven G. Greening

{"title":"Promoting brain health and resilience: The effect of three types of acute exercise on affect, brain-derived neurotrophic factor and heart rate variability","authors":"Thomas Rawliuk , Mikal Thrones , Dean M. Cordingley , Stephen M. Cornish , Steven G. Greening","doi":"10.1016/j.bbr.2025.115675","DOIUrl":"10.1016/j.bbr.2025.115675","url":null,"abstract":"<div><div>Physical exercise supports brain health and resilience through a variety of factors involving affective states, neurotrophins, and autonomic activity. These factors play a crucial role in supporting mental and physical health across the lifespan. We evaluated the acute effects of moderate-intensity continuous exercise, high-intensity interval exercise, and resistance exercise on positive and negative affect, Brain Derived Neurotrophic Factor (BDNF), and Heart Rate Variability (HRV). In a repeated measures cross-over design, 12 participants over 5 weeks underwent all three exercise types while affect, phlebotomy, and cardiac, measures were taken pre-, immediately post-, 30-minutes, and 60-minutes post-exercise. We found an increase in plasma BDNF concentrations irrespective of exercise type from immediately pre-exercise to post-exercise. The HRV analysis identified a decrease in root mean square of successive differences (RMSSD) immediately post-exercise, followed by a gradual increase to above pre-exercise levels at 60-minutes post exercise. We also observed a decrease in negative affect following exercise that was sustained till 60-minutes post-exercise. Taken together, the results suggest that although exercise type did not differentially affect negative affect, BDNF, or HRV, all three measures suggested a consistent physiological and psychological improvement post-exercise, highlighting the potential benefits of various forms of exercise on aspects of brain health and resilience.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"493 ","pages":"Article 115675"},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking motor impulsivity to cue-induced craving and central beta oscillations in individuals with methamphetamine use disorder 甲基苯丙胺使用障碍个体的运动冲动与线索诱导的渴望和中枢β振荡的联系。

IF 2.6 3区心理学

Behavioural Brain Research Pub Date : 2025-05-29 DOI: 10.1016/j.bbr.2025.115663

Xiaohuanghao Yang , Yun Zhao , Jing Li , Yongguang Wang

引用次数: 0