{"title":"Comparative efficacy of acupuncture-related therapies for Parkinson's disease: A systematic review and network meta-analysis.","authors":"Xuqing Mao, Wenrui Huang, Shanshan Zhang, Ting Chen, Lei Chen, Xiping Liu, Yibin Zhao","doi":"10.1016/j.bbr.2025.115848","DOIUrl":"10.1016/j.bbr.2025.115848","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a prevalent neurodegenerative disorder marked by progressive motor and non-motor symptoms. Although levodopa remains the standard therapy, long-term use leads to reduced efficacy and motor complications. Acupuncture-related therapies have gained attention as safe, affordable adjuncts, but the comparative effectiveness of different modalities remains uncertain.</p><p><strong>Method: </strong>We conducted a comprehensive search of Chinese and international databases to identify randomized controlled trials (RCTs) evaluating the effectiveness of acupuncture-related therapies for PD. Eligible studies were selected based on predefined PICOS criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias using the RoB 2.0 tool. A frequentist network meta-analysis was performed using Stata SE 15.1. For continuous outcomes, mean differences were calculated; for binary outcomes, risk ratios were used. A random-effects model was applied, with heterogeneity assessed by τ² and consistency tested across the network. SUCRA values were calculated to rank the comparative efficacy of interventions.</p><p><strong>Result: </strong>Fifty-seven RCTs (n = 4262; 2002-2024) were included. Interventions comprised manual acupuncture (MA), electroacupuncture (EA), warm acupuncture (WA), fire acupuncture (FA), and moxibustion (MOX), used alone or in combination with conventional medication (CM) or Chinese herbal medicine (CHM). For total effective rate (41 RCTs; n = 3086), the most pronounced benefit was observed with EA + WA + CM (RR = 3.00; 95 % CI: 1.20-7.48; SUCRA = 97 %; moderate confidence). Significant improvements were also found for MOX + CM (RR = 1.33; 1.07-1.64; SUCRA = 68.8 %), MA + CM (RR = 1.20; 1.10-1.32; SUCRA = 51.7 %), and EA + CM (RR = 1.15; 1.05-1.26; SUCRA = 38.3 %). For UPDRS (36 RCTs; n = 2655), MA + CM significantly improved motor symptoms compared with CM (MD = -0.89; 95 % CI: -1.58 to -0.20; SUCRA = 61.6 %; moderate certainty). For Webster score (5 RCTs; n = 444), both EA + CM (MD = -3.65; -5.01 to -2.28; SUCRA = 91.1 %) and MA + CM (MD = -2.62; -4.31 to -0.92; SUCRA = 61.8 %) were superior to CM. For HAMD (11 RCTs; n = 802), significant reductions in depressive symptoms were observed with MA + CM (MD = -2.41; 95 % CI: -3.48 to -1.34; SUCRA = 91.9 %) and EA + CM (MD = -2.16; 95 % CI: -3.74 to -0.58; SUCRA = 62.8 %). CINeMA ratings were low to moderate for most pairwise comparisons.</p><p><strong>Conclusion: </strong>Acupuncture-based therapies provided added benefits over conventional medication for Parkinson's disease. EA + WA + CM showed the most consistent improvement in overall effectiveness, MA + CM was most effective for motor symptoms, EA + CM and MA + CM demonstrated superiority for Webster scores, and MA + CM also performed best for depressive symptoms. Although the certainty of evidence ranged from low to moderate, these findings suggest that tai","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115848"},"PeriodicalIF":2.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily M. Tirrell , Nahid Kalantaryardebily , Julia Hocker , Caleb Bowles , Kevin Parcetich , Netta Gurari
{"title":"Impact of an auditory cognitive load on consciously perceiving electrotactile stimuli in young adults","authors":"Emily M. Tirrell , Nahid Kalantaryardebily , Julia Hocker , Caleb Bowles , Kevin Parcetich , Netta Gurari","doi":"10.1016/j.bbr.2025.115841","DOIUrl":"10.1016/j.bbr.2025.115841","url":null,"abstract":"<div><h3>Purpose:</h3><div>Tactile perception plays a critical role in sensorimotor integration and functional task performance. Consequently, the various factors, and their interactions, that influence tactile perception are of interest when considering daily function. One such factor, cognitive-perceptual load, is of particular interest, as it reflects the mental demands placed on an individual during complex, multisensory tasks. To examine this cognitive-perceptual factor, this study evaluated how discriminating auditory stimuli impacts tactile detection and discrimination while also considering additional factors including arm dominance, sex, and age.</div></div><div><h3>Methods:</h3><div>Participants completed a series of electrotactile detection and discrimination tasks under single (tactile only) and dual (tactile and auditory) conditions. Auditory stimuli were introduced via a partial auditory Stroop test. Secondary factors of interest included arm dominance, sex, stimulation site, and their interactions.</div></div><div><h3>Results:</h3><div>Primary outcomes included electrotactile detection and discrimination thresholds and variability. Detecting electrotactile stimuli while also discriminating auditory stimuli significantly impacted the precision (p = 0.030), yet not threshold (p = 1.000), for detecting the electrotactile stimuli. In contrast, discriminating electrotactile stimuli while also discriminating auditory stimuli significantly impacted the threshold (p<span><math><mo><</mo></math></span>0.001), yet not precision (p = 1.000), in discriminating the electrotactile stimuli. Arm dominance significantly impacted the threshold at which the electrotactile stimuli could be detected (p<span><math><mo><</mo></math></span>0.001) and discriminated (p<span><math><mo><</mo></math></span>0.001). Participant sex and stimulation location (elbow, hand) had a significant interaction effect when detecting (p<span><math><mo><</mo></math></span>0.001), yet not discriminating (p = 1.000) the electrotactile stimuli.</div></div><div><h3>Conclusion:</h3><div>This work examined the impact of a cognitive-perceptual load on perceiving tactile stimuli, and highlighted additional important factors including arm dominance, sex, and stimulation location when assessing tactile perception in young adults. Results suggest that perceiving auditory stimuli increased the variability in detecting electrotactile stimuli. Additionally, perceiving auditory stimuli increased the threshold for discriminating electrotactile stimuli. Future work can expand these investigations to include differing populations including individuals following a neurological injury.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115841"},"PeriodicalIF":2.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole E. Chambers , Annique McLune , Michael Coyle , Ashley Centner , Jordan Sergio , Isabella Del Priore , Kathryn Lanza , Craig W. Lindsley , P. Jeffrey Conn , Christopher Bishop
{"title":"Investigating the role of rostral pedunculopontine nucleus M4 receptors in motor deficits and dyskinesia in hemiparkinsonian rats","authors":"Nicole E. Chambers , Annique McLune , Michael Coyle , Ashley Centner , Jordan Sergio , Isabella Del Priore , Kathryn Lanza , Craig W. Lindsley , P. Jeffrey Conn , Christopher Bishop","doi":"10.1016/j.bbr.2025.115847","DOIUrl":"10.1016/j.bbr.2025.115847","url":null,"abstract":"<div><div>Standard treatment for Parkinson’s disease (PD) is dopamine replacement therapy with L-DOPA. However, chronic treatment often results in abnormal involuntary movements called L-DOPA-induced dyskinesia (LID). Prior evidence indicates that heightened striatal cholinergic tone may contribute to LID. Restoring cholinergic inhibition by targeting the inhibitory M<sub>4</sub> muscarinic acetylcholine (ACh) receptor (M<sub>4</sub>) reduces LID in preclinical models. Although intrinsic striatal sources of ACh have been considered for their role in LID, extrinsic sources of ACh such as the pedunculopontine nucleus (PPN) have not been well investigated for their role in LID. Therefore, the current study employed hemiparkinsonian Long-Evans rats with a PPN-targeted cannula ipsilateral to 6-OHDA lesion. We examined the effect of local unilateral PPN infusion of M<sub>4</sub> PAM VU0467154 on LID, motor performance, and c-fos expression within the PPN. It was expected that PPN infusion of VU0467154 would reduce LID, reduce L-DOPA’s motor benefit, and globally reduce c-fos expression in the PPN. Contrary to our expectations, PPN infusion of M<sub>4</sub> PAM did not significantly affect LID severity. Furthermore, M<sub>4</sub> PAM did not alter L-DOPA-mediated motor improvement, and decreased c-fos expression specifically in PPN cholinergic neurons. These results suggest that local PPN ACh dynamics differ from those of the striatum. In the context of prior work, our results suggest that PPN cholinergic modulation or global PPN modulation may be a promising strategy for altering freezing of gait without decreasing motor benefit of L-DOPA and without increasing LID severity.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115847"},"PeriodicalIF":2.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mami Terao, Hiroki Furuie, Mitsuhiko Yamada, Kosuke Sawa
{"title":"Corrigendum to \"Behavioral investigation of the sense of agency in rats by manipulating temporal delays between response and outcome: Insights from a causal reasoning task\" [Behav. Brain Res. 496 (2026) 115814].","authors":"Mami Terao, Hiroki Furuie, Mitsuhiko Yamada, Kosuke Sawa","doi":"10.1016/j.bbr.2025.115844","DOIUrl":"https://doi.org/10.1016/j.bbr.2025.115844","url":null,"abstract":"","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115844"},"PeriodicalIF":2.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Louise Manfron , Lieve Filbrich , Delia Della Porta , André Mouraux , Valéry Legrain
{"title":"Multisensory impact of visual stimuli on detection thresholds of thermo-nociceptive inputs conveyed by Aδ and C fibers","authors":"Louise Manfron , Lieve Filbrich , Delia Della Porta , André Mouraux , Valéry Legrain","doi":"10.1016/j.bbr.2025.115846","DOIUrl":"10.1016/j.bbr.2025.115846","url":null,"abstract":"<div><div>Nociception is seen as an alarm system that allows detecting and reacting to potential physical threats. It is hypothesized that such alarming function is optimized through interactions with other sensory systems such as vision that allows identifying surrounding objects that might have an immediate impact on the body. Here, we test the hypothesis according to which visual stimuli could modulate the response threshold to heat stimuli. Using an adaptive psychophysical procedure allowing, among other things, to take into account differences in conduction distance and velocity within visual and thermo-nociceptive pathways, laser-induced thermal stimuli of different temperatures were applied on one hand dorsum, and detection thresholds of thermal sensations conveyed by C- and Aδ-fibers were measured, respectively. Measures were taken while visual stimuli were presented either near the stimulated hand, near the opposite hand or at a neutral position in front of the participant. Results showed that the detection threshold of Aδ fibers was decreased when the visual stimuli occurred near the stimulated hand as compared to when they occurred near the opposite hand. Such modulation of nociceptive thresholds by non-somatic stimuli, at least that of Aδ fibers, could reflect a defensive mechanism to facilitate detection and response to external threats. Conversely, due to their slow conduction velocity, sensory inputs conveyed through C fibers could be less sensitive to multisensory interactions because they would be less involved in immediate defensive reactions and more involved in monitoring the general state of the body.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115846"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Espejo-Antúnez, Carlos Fernández-Morales, Manuel Albornoz-Cabello, María de Los Ángeles Cardero-Durán
{"title":"Corrigendum to \"Does pain location influence heart rate variability? A comparative analysis of patients with neck or low back pain, and healthy controls\" [Behav. Brain Res. 495 (2025), 115811].","authors":"Luis Espejo-Antúnez, Carlos Fernández-Morales, Manuel Albornoz-Cabello, María de Los Ángeles Cardero-Durán","doi":"10.1016/j.bbr.2025.115845","DOIUrl":"https://doi.org/10.1016/j.bbr.2025.115845","url":null,"abstract":"","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":" ","pages":"115845"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benke Xu, Yaocong Yang, Zijie Huang, Jiahao Li, Guoxiao Sun
{"title":"Effects of acute HIIE combined with meditation on cognitive function among sedentary college students: An fNIRS study","authors":"Benke Xu, Yaocong Yang, Zijie Huang, Jiahao Li, Guoxiao Sun","doi":"10.1016/j.bbr.2025.115843","DOIUrl":"10.1016/j.bbr.2025.115843","url":null,"abstract":"<div><h3>Background</h3><div>Prolonged sedentary behavior is prevalent among Chinese college students. As representatives of the younger demographic, college students face a multitude of academic, social, and personal challenges, underscoring the need for effective strategies to enhance their cognitive function. This study aimed to evaluate the effects of acute high-intensity interval exercise (HIIE) combined with meditation on the cognitive performance of sedentary college students.</div></div><div><h3>Methods</h3><div>A total of 51 sedentary college students (mean age: 20.24 ± 2.19 years) participated in this study. Participants were randomly assigned to one of three groups: a group performing HIIE combined with meditation, a group performing only HIIE, and a control group. To examine the effects of acute HIIE with and without meditation, as well as a control condition, functional near-infrared spectroscopy (fNIRS) was used to measure changes in cortical hemodynamics (i.e., oxygenated and deoxygenated hemoglobin) during an executive functioning task (Stroop test).</div></div><div><h3>Results</h3><div>Both acute HIIE combined with meditation [F = 7.783, p = 0.008, η² = 0.140] and acute HIIE alone [F = 37.231, p < 0.001, η² = 0.437] significantly improved cognitive performance in sedentary college students. During the Stroop task, the activation of the left dorsolateral prefrontal cortex (L-DLPFC) was significantly enhanced when combining HIIE with meditation. However, following HIIE alone, a higher activation of both the L-DLPFC and right frontopolar area (R-FPA) was observed.</div></div><div><h3>Conclusions</h3><div>Both the combined intervention (HIIE and meditation) and HIIE alone had positive effects on cognitive performance in sedentary college students. In the short term, HIIE alone demonstrated a greater impact on cognitive enhancement.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115843"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of acridine derivatives as acetylcholinesterase inhibitors: Cytotoxicity, molecular interactions, and neuroprotective potential in AD","authors":"E. Joel Mart, C. Ronald Darwin","doi":"10.1016/j.bbr.2025.115842","DOIUrl":"10.1016/j.bbr.2025.115842","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is characterized by progressive neurodegeneration, memory impairment, and neuroinflammation. Acetylcholinesterase (AChE) represents a critical therapeutic target due to its role in acetylcholine regulation and amyloid-beta aggregation. This study evaluated five synthesized acridine derivatives (AAM7, AAM5, AC8, AC6, AM1) as potential AChE inhibitors through molecular docking, dynamics simulations, ADMET profiling, and cytotoxicity assessment using SH-SY5Y neuroblastoma cells. Molecular docking revealed AAM7 exhibited the highest binding affinity (-10.6 kcal/mol) to AChE, followed by AAM5, AC6, and AC8 (each −10.2 kcal/mol), while AM1 showed the lowest affinity (-9.1 kcal/mol). Molecular dynamics simulations confirmed AAM7's stable protein-ligand interactions with consistent hydrogen bonding (>70 % trajectory occupancy) and π-π stacking with key residues Tyr124, Asp74, Ser125, and Trp86. ADMET analysis demonstrated favorable CNS penetration for all compounds, with AAM7 showing optimal drug-like properties (MW: 383.49 g/mol, LogP: 4.65, TPSA: 45.23 Ų) despite moderate solubility concerns. Cytotoxicity studies revealed AC6 as the most potent compound (IC₅₀: 135.56 μg/ml), followed by AM1 (IC₅₀: 202.36 μg/ml), while AAM7 demonstrated minimal cytotoxicity (IC₅₀: 394.02 μg/ml), indicating superior safety profile. Network analysis identified AChE as a central hub protein in neurodegeneration pathways. These findings establish AAM7 as a promising lead compound for AD therapy, combining strong AChE binding affinity with favorable safety characteristics, warranting further optimization for clinical development.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115842"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurological and behavioural correlates of construal in economic decision-making under cognitive load","authors":"Christopher J. Wilson","doi":"10.1016/j.bbr.2025.115829","DOIUrl":"10.1016/j.bbr.2025.115829","url":null,"abstract":"<div><div>Construal level has been shown to influence economic decisions, affecting both risk perception and risk-taking. However, there has been some inconsistency as to the exact effects of high/low construal on economic decisions, with some findings suggesting that construal might interact with cognitive load and self-control in a risk-taking context. In two experiments, the current paper examines behavioural and neurological (using functional near-infrared spectroscopy) responses to high and low construal manipulations during and economic decision task, under experimentally-induced cognitive load. We also examine the how construal interacts with self-control, financial literacy and subjective numeracy to predict lateral pre-frontal cortex (LPFC) activation during these decisions. Some of the behavioural results supported previous findings that under cognitive load, high construal prompts risk aversion. Neurological data supported the theory that construal promotes risk sensitivity. Self-control, financial literacy and subjective numeracy were all found to interact with construal in predicting LPFC activation during decision-making. These findings extend our understanding of how construal effects economic decisions under cognitive load while also providing new insights into how self-control, financial literacy and subjective numeracy might interact with construal in this context.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115829"},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alyse N. Maksimoski , Changjiu Zhao, Ella Butzine, Lauren V. Riters
{"title":"Sexually-motivated song correlates with opioid- and dopamine-related gene expression in the rostral nucleus accumbens of male European starlings","authors":"Alyse N. Maksimoski , Changjiu Zhao, Ella Butzine, Lauren V. Riters","doi":"10.1016/j.bbr.2025.115839","DOIUrl":"10.1016/j.bbr.2025.115839","url":null,"abstract":"<div><div>Recent studies on songbirds reveal that the nucleus accumbens (NAc) plays a role in facilitating and rewarding “gregarious” singing behavior, a form of communication produced outside a mating context that plays a role in flock cohesion. In addition to its role in reward, the NAc and both opioids and dopamine in this region are known to modulate incentively-motivated behaviors, including sexually-motivated behaviors. This raises the possibility that in addition to gregarious birdsong, the NAc may also play a role in “sexually-motivated” male courtship song. The goal of the present study was to provide insight into this hypothesis using RNAscope and behavioral observations to identify relationships between the expression of opioid- and dopamine-related genes, song, and other social behaviors. Negative correlations were identified between a principal behavioral component containing sexually-motivated song and preening and the expression of both pre-proenkephalin [PENK] and the dopamine D1 receptor [DRD1] gene in NAc. The expression of the mu opioid receptor [OPRM1] gene in NAc correlated negatively with social motivation, reflected in the propensity to spend time near a large compared to a small group, with a similar trend observed for DRD2. Results are the first to reveal a potential role for the NAc in sexually-motivated song and to suggest that specific patterns of opioid- and dopamine-related gene expression within a rostral portion of the songbird NAc may play distinct roles in sexually-motivated song, preening and social motivation.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"496 ","pages":"Article 115839"},"PeriodicalIF":2.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}