Behavioural Brain Research最新文献

{"title":"Differences in frontal cortical brain function between individuals suffering from pathological mental fatigue following acquired brain injury and healthy individuals","authors":"Gustaf Glavå ,&nbsp;Simon Skau ,&nbsp;Martin Lövdén ,&nbsp;Birgitta Johansson","doi":"10.1016/j.bbr.2025.115631","DOIUrl":"10.1016/j.bbr.2025.115631","url":null,"abstract":"<div><div>Pathological mental fatigue (PMF) is a common health concern after acquired brain injuries, with tens of millions affected globally each year. Neuroimaging methods show promising results for establishing associations between PMF and brain function. The aim of this study was to investigate whether and how neural functional activity and connectivity differ during rest and cognitive tasks between people with PMF and healthy controls. Twenty participants suffering from PMF after an acquired brain injury (ABI; stroke or traumatic brain injury) and 19 healthy controls were recruited and underwent cognitive tests and functional near infrared spectroscopy (fNIRS) assessments. The results show that the PMF group and controls exhibited different functional brain activation in the frontal cortex, concerning both neural connectivity and activity. More specifically, the PMF group showed higher Global Efficiency and lower Modularity during resting state and when performing the cognitive tasks Digit Symbol Coding and Symbol Search. The groups also differed in peak oxygenated hemoglobin during the BASE task, with lower oxygenation in the PMF group. In addition, the PMF group was significantly slower than the control group in both neutral and incongruent Stroop trials. However, no group differences were observed in neural activity during the Stroop task, and nor were there differences in reactivity or proactivity as measured using the AX-CPT test. This study has developed the knowledge on the brain correlates of PMF. Future studies should explore the theoretical and practical implications of these results.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115631"},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced analgesia: Synergistic effects of melatonin and tramadol on acute thermal nociception in Wistar rats via tail-flick and hot-plate tests","authors":"Emine Çakırgöz ,&nbsp;Gülçin Durdağı ,&nbsp;Eser Öz Oyar","doi":"10.1016/j.bbr.2025.115641","DOIUrl":"10.1016/j.bbr.2025.115641","url":null,"abstract":"<div><h3>Background/aim</h3><div>The aim of the study is to evaluate the antinociceptive effects of Tramadol+Melatonin [using Hot-plate (HP) and Tail-flick (TF) tests] at the behavioral level and to investigate its effects on motor coordination (using the Rotarod test) in acute pain.</div></div><div><h3>Materials and methods</h3><div>Thirty-two male Wistar albino rats, 8 weeks old and weighing 250–300 g, were used. The rats were randomly divided into four groups of eight animals each [Control, Tramadol (20 mg/kg), Melatonin (120 mg/kg), and Tramadol+Melatonin (20 mg/kg+120 mg/kg)]. The rats were trained to walk on the rotarod for 3 days prior to the experiment. Thermal acute nociception was assessed in rats using two TF tests and one HP test. Measurements were recorded before drug administration (baseline) and at 15, 30, 60, 90, and 120 minutes post-administration.</div></div><div><h3>Results</h3><div>Significantly higher values were obtained in both the HP and TF tests compared to the control, Melatonin, and Tramadol groups at various time points. In the Rotarod test, the baseline values of the Melatonin and Tramadol+Melatonin groups were significantly longer at certain post-administration time points.</div></div><div><h3>Conclusion</h3><div>The findings indicate a potential synergistic interaction between melatonin and tramadol, as evidenced by improved pain sensitivity thresholds. These results underscore the necessity for further clinical investigations to elucidate the therapeutic advantages and underlying mechanisms of this combination. Such research could significantly contribute to the development of more efficacious pain management protocols.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115641"},"PeriodicalIF":2.6,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired cognitive function and altered dendritic morphology of hippocampal neurons in a mouse model of fetal alcohol spectrum disorder","authors":"Yu Cai ,&nbsp;Jia-Chun Wu ,&nbsp;Ying Huang ,&nbsp;Xue-Feng Yu ,&nbsp;Fu-He Liu ,&nbsp;Zi-Wei Chen ,&nbsp;Da-Peng Gao","doi":"10.1016/j.bbr.2025.115633","DOIUrl":"10.1016/j.bbr.2025.115633","url":null,"abstract":"<div><div>Prenatal ethanol exposure is a leading preventable cause of neurodevelopmental disability, clinically categorized under fetal alcohol spectrum disorders (FASD). This study explores how developmental alcohol exposure affects the dendritic morphology of hippocampal pyramidal neurons, focusing on the actin cytoskeleton's dynamics essential for neuronal structure and synaptic function. Within this context, we hypothesized that developmental alcohol exposure disrupts actin cytoskeleton dynamics, leading to cognitive deficits and dendritic remodeling in the hippocampus. Neonatal mice (C57BL/6 J) were administered ethanol (5.0 g/kg) intraperitoneally from postnatal day 2–8, establishing a third trimester-equivalent alcohol exposure FASD model. At postnatal day 28, cognitive performance was evaluated using novel location recognition (NLR), novel object recognition (NOR), and the Morris water maze (MWM). Golgi staining assessed dendritic morphology in the hippocampal CA1 region, and the ratio of polymerized (F-actin) to globular actin (G-actin) was measured using a biochemical assay. The results revealed that developmental alcohol exposure significantly impaired recognition and spatial memory, as evidenced by decreased performances in the NOR and MWM tests across both sexes. Golgi staining revealed reduced dendritic arborization complexity and spine density in the CA1 region of the hippocampal pyramidal neurons of both male and female juvenile mice. Biochemical analyses further revealed decresed hipocampal F-actin/G-actin ratios and decreased levels of polymerized F-actin in both sexes. These findings underscore the critical role of cytoskeletal integrity in cognitive development and highlight potential targets for therapeutic intervention in FASD.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115633"},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotonin mitigates depression in a rotenone-induced mouse Parkinson’s disease model by inhibiting hippocampal neuronal pyroptosis and neuroinflammation","authors":"Jian Wang ,&nbsp;Hong Zhang","doi":"10.1016/j.bbr.2025.115620","DOIUrl":"10.1016/j.bbr.2025.115620","url":null,"abstract":"<div><div>Depression in Parkinson’s disease (dPD) is a prevalent comorbidity significantly impairing patients’ quality of life. Emerging evidence highlights the pivotal role of neuroinflammation in dPD pathogenesis, particularly the interaction between neuronal pyroptosis and microglial polarization. Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in mood regulation and neuroinflammatory processes, yet its role in modulating pyroptosis and microglial polarization remains unclear. Therefore, this study aimed to investigate neuronal pyroptosis and microglial polarization in dPD pathogenesis and explore the regulation of 5-HT on these processes. A C57BL/6 mouse model of dPD was established using injected intraperitoneally of rotenone to observe changes in body weight, sucrose preference, and exercise time. ELISA and Western blotting were used to detect the expression of relevant proteins and cytokines in the hippocampus. Co-culture experiments with HT22 and BV2 cells were conducted to explore the effect of 5-HT on neuronal pyroptosis and microglial polarization. Rotenone-induced dPD in mice led to reduced body weight, sucrose preference, and activity, accompanied by upregulation of pyroptosis markers (NLRP1, N-GSDMD, Cleaved-caspase-1) and increased M1 microglial polarization. Treatment with 5-HT and the pyroptosis inhibitor Pep19–2.5 reversed these changes, mitigating neuronal pyroptosis and shifting microglial polarization towards a less inflammatory profile. In vitro, 5-HTP suppressed LPS-induced neuronal pyroptosis, reducing TNF-α, IL-1β, IL-18 levels and oxidative stress while preserving microglial viability. The 5-HT inhibitor Scopolamine abolished these effects. Neuronal pyroptosis and M1 microglial polarization contribute critically to dPD pathogenesis. By inhibiting these processes, 5-HT emerges as a promising therapeutic target for managing dPD, offering new insights into its treatment mechanisms.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115620"},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of High-Intensity Interval Training (HIIT) on miR-29c and miR-146a expression in the hippocampus of streptozotocin-induced diabetic rats","authors":"Mehdi Soltani Ichi,&nbsp;Fatemeh Shabkhiz,&nbsp;Mohammadreza Kordi","doi":"10.1016/j.bbr.2025.115632","DOIUrl":"10.1016/j.bbr.2025.115632","url":null,"abstract":"<div><h3>Background</h3><div>MicroRNAs like miR-146a and miR-29c are potential biomarkers for diabetes, which is linked to brain impairments such as cognitive decline and hippocampal dysfunction due to hyperglycemia and inflammation. This study investigates the effects of high-intensity interval training (HIIT) on hippocampal miR-146a and miR-29c expression and serum TNF-α levels in diabetic rats, highlighting its role in reducing inflammation and improving brain function.</div></div><div><h3>Methods</h3><div>Twenty-four male Wistar rats were divided into four groups: Control (Normal), 1-week diabetes (Diabetes 1 W), 6-week diabetes (Diabetes 6 W), and diabetic HIIT (Diabetes-Exe). Diabetes was induced using streptozotocin (55 mg/kg) and rats with blood glucose &gt; 250 mg/dL were included. HIIT was conducted for six weeks, and hippocampal miR-146a, miR-29c expression, and TNF-α serum levels were assessed using Real-Time PCR and ELISA. TNF-α serum levels were measured as a marker of systemic inflammation.</div></div><div><h3>Results</h3><div>Diabetic rats exhibited decreased miR-146a and increased miR-29c expression in the hippocampus compared to controls. Additionally, TNF-α serum levels were significantly higher in the diabetic groups, indicating an elevated inflammatory state. HIIT in the Diabetes-Exe group resulted in a non-significant change in miR-29c expression and TNF-α serum levels, accompanied by a significant increase in miR-146a expression compared to the Diabetes 6 W group.</div></div><div><h3>Conclusion</h3><div>HIIT exercise may help reduce hippocampal neuronal damage in diabetic rats by modulating miR-146a expression, improving blood glucose control, and reducing inflammation. Although HIIT did not significantly alter miR-29c expression, its potential as an effective non-pharmacological strategy for managing diabetic neuropathy complications cannot be excluded.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"489 ","pages":"Article 115632"},"PeriodicalIF":2.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway","authors":"Yue Liu ,&nbsp;Yun Zhai ,&nbsp;Lili Ma ,&nbsp;Zhi Wang ,&nbsp;Jing Wang ,&nbsp;Bifeng Hu ,&nbsp;Ying Tang","doi":"10.1016/j.bbr.2025.115619","DOIUrl":"10.1016/j.bbr.2025.115619","url":null,"abstract":"<div><div>White matter lesions (WMLs) caused by chronic cerebral hypoperfusion (CCH) are closely related to the activation of microglia. Inhibition of microglia overactivation is considered as a protective strategy for WMLs. Based on its anti-inflammatory properties and clinical benefits, colchicine has become a hot spot in the drug treatment and research of vascular diseases. However, its role in vascular cognitive impairment (VCI) remains unclear. In this study, BCAS model was established to induce CCH, simulate subcortical white matter lesions, and examine the effect of colchicine on WMLs after BCAS. The basic parameters of body weight and blood pressure were monitored. Behavioral evaluation included the Open Field test, Y maze and Morris Water Maze to evaluate the motor ability and cognitive level of mice respectively. The cerebral blood flow was detected by Laser Speckle Imaging (LSI). Transmission Electron Microscopy, LFB staining, corpus callosum MBP and MAG western blot levels, and mouse brain T2-weighted imaging were used to detect demyelination and white matter changes. The expression of IBA1 was determined by immunohistochemistry and western blot, and the correlation between IBA1 staining and behavioral parameters was analyzed. The expression of brain inflammatory factors was detected by Elisa. It was found that colchicine may alleviates VCI through MAPK/NF-κB pathway by means of network pharmacology enrichment analysis from the perspective of inflammation, and the classical inflammatory proteins TAK1, p38, JNK, and p65 of this pathway were subsequently detected in in vivo and in vitro models. The anti-inflammatory spectrum of colchicine, including IL-1β, IL-6, COX2, CD86 and anti-inflammatory effects, were extensively evaluated by RT-qPCR, western blot, wound healing and transwell tests on BV2 microglia stimulated by low concentration of LPS in vitro. This study shows that colchicine can improve the cognitive impairment of BCAS mice, and the specific mechanism is to regulate the inflammation of microglia by inhibiting the classical inflammatory pathway of TAK1/MAPK/NF-κB, thereby reducing WMLs and improving the cognitive impairment behavior.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115619"},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habits and vulnerability or resilience to stress – Impact on depressive disorders","authors":"Amanda Gollo Bertollo ,&nbsp;Milene Zanella Capitanio ,&nbsp;Laysa Anacleto Schuh ,&nbsp;Nandara Pradella ,&nbsp;Zuleide Maria Ignácio","doi":"10.1016/j.bbr.2025.115630","DOIUrl":"10.1016/j.bbr.2025.115630","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is prevalent worldwide and impacts the health and quality of life of millions of people. MDD is a condition influenced by a complex interplay of genetic, psychological and environmental factors. This narrative review examines the roles of stress vulnerability, resilience, and lifestyle habits in shaping the risk of depression, emphasizing holistic approaches that address both biological and environmental factors in mental health management. Vulnerability to stress, influenced by factors such as childhood adversity and personality traits such as neuroticism, increases the probability of MDD. On the other hand, resilience acts as a protective mechanism, reducing stress reactivity and supporting mental health. The main findings suggest that healthy lifestyle habits, including consistent sleep patterns, a balanced diet and regular exercise, play significant roles in increasing resilience and preventing depressive symptoms. Interventions to build resilience, such as emotional skills training and promoting a growth mindset, have been proven effective in reducing depressive symptoms. Overall, the findings suggest that lifestyle modifications combined with psychological strategies to build resilience can significantly reduce depressive disorders. This study advocates for personalized therapeutic strategies that consider the multifactorial nature of depressive disorders, integrating psychological and lifestyle interventions to enhance resilience and mental health.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115630"},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Love addiction symptoms and subjective cognitive complaints: The mediator role of depression and anxiety and the impact of social media use","authors":"Gianpaolo Maggi ,&nbsp;Chiara Giacobbe ,&nbsp;Lorenzo Borrello ,&nbsp;Angelo Barone ,&nbsp;Clara Mastromarino ,&nbsp;Paolo Antonelli ,&nbsp;Gabriella Santangelo","doi":"10.1016/j.bbr.2025.115621","DOIUrl":"10.1016/j.bbr.2025.115621","url":null,"abstract":"<div><div>Love addiction (LA) can lead to adverse psychological, social, and cognitive consequences. However, the relationship between LA symptoms and perceived cognitive function, as well as the contribution of social media use, remains unclear. The present study aimed to unravel the exact nature of these relationships in a large Italian sample using an online questionnaire. We found that individuals with even mild LA symptoms experienced reduced everyday memory ability and more severe cognitive failures during daily activities and at work, compared to those without LA. Psychological symptoms mediated the effect of LA symptoms on perceived cognitive function, with the use of social media as a strong risk factor for LA development. LA deserves more scientific attention to provide clinicians with a clinical framework and spread awareness of its harmful consequences involving cognitive aspects. Awareness should encourage most at-risk individuals to recognize early LA manifestations and seek professional help for mental health care.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115621"},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensing the beauty of interface: Neural oscillatory correlates of visual aesthetic judgment","authors":"Yanci Liu ,&nbsp;Shiyu Zhang ,&nbsp;Zheng Jiang ,&nbsp;Feng Du","doi":"10.1016/j.bbr.2025.115623","DOIUrl":"10.1016/j.bbr.2025.115623","url":null,"abstract":"<div><div>It is critical for manufacturers to assess customers' aesthetic preferences for various interfaces. However, few studies on neural oscillations for aesthetic judgment have yielded inconsistent results. In this study, we explored the EEG oscillations linked to aesthetic judgments using interface materials (from aesthetic to medium and unaesthetic) along with corresponding scrambled images. Present findings showed that theta-band synchronization to interface were significantly higher for aesthetic interfaces than unaesthetic ones during 200–240 ms at the bilateral occipitotemporal electrodes. However, no significant differences in theta-band oscillations were observed between scrambled images of aesthetic and unaesthetic interfaces. During 250–300 ms, similar theta oscillation patterns were found only at the right occipitotemporal electrodes. Meanwhile, during 220–270 ms, aesthetic interfaces induced stronger alpha-beta desynchronization than unaesthetic ones at the left frontal electrodes, and still no such significant differences were observed in scrambled images. These EEG oscillations could serve as valuable real-time indicators for assessing individual aesthetic judgments.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"489 ","pages":"Article 115623"},"PeriodicalIF":2.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-type calcium channel blockade attenuates cue-induced cocaine-seeking in female rats","authors":"Violet M. Kimble ,&nbsp;Eric J. Nunes ,&nbsp;Anjali M. Rajadhyaksha ,&nbsp;Nii A. Addy","doi":"10.1016/j.bbr.2025.115613","DOIUrl":"10.1016/j.bbr.2025.115613","url":null,"abstract":"<div><div>Periods of cocaine abstinence are associated with a high risk of relapse, often triggered by exposure to drug-associated cues. Previous research has implicated L-type calcium channels (LTCCs) in drug-seeking behaviors, yet their role in cue-induced relapse, particularly in females, remains underexplored. This study investigated the effects of LTCC inhibition on cue-induced cocaine-seeking behavior during abstinence in female Sprague-Dawley rats. Following a 10-day cocaine self-administration and a 14-day forced abstinence period, the rats were tested for cue-induced cocaine-seeking after receiving systemic administration of isradipine, a non-selective LTCC inhibitor (0.0 mg/kg, 0.1 mg/kg, 0.4 mg/kg, or 1.2 mg/kg, i.p.). Isradipine significantly reduced cue-induced cocaine-seeking in a dose-dependent manner without affecting cocaine-taking or natural reward-taking or seeking behaviors. Notably, these findings in females were comparable to our prior results observed in males, demonstrating that LTCC inhibition selectively attenuates the impact of cocaine-associated cues across sexes. These results highlight the translational potential of LTCCs as a therapeutic agent to reduce relapse risk in cocaine-dependent individuals. This study underscores the importance of considering sex-specific mechanisms in addiction treatment and calls for further research into LTCCs as a target for relapse prevention.</div></div>","PeriodicalId":8823,"journal":{"name":"Behavioural Brain Research","volume":"490 ","pages":"Article 115613"},"PeriodicalIF":2.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}