与神经发育及相关疾病相关的胎盘改变。

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-07-05 DOI:10.1016/j.bbr.2025.115721

Isabela Drehmer , Brayan Braz-Barbosa , Carmem Gottfried , Júlio Santos-Terra , Iohanna Deckmann

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引用次数: 0

摘要

神经发育障碍（ndd），如自闭症谱系障碍（ASD）和注意力缺陷和多动障碍（ADHD），是在胚胎期神经发育期间触发并持续到出生后的情况，导致行为障碍。尽管患病率不断上升，研究也越来越广泛，但这两种疾病病因背后的机制尚不完全清楚。这篇叙述性综述探讨了遗传和环境风险因素在胎盘中的复杂相互作用，胎盘是胎儿维持的关键瞬时器官，它在母亲和胎儿之间双向传递营养物质、气体、废物、激素和炎症介质中的作用。我们提出了与ndd （ASD和ADHD）和胎儿酒精谱系障碍（FASD）诊断相关的胎盘改变的全面概述。通过这篇综述，潜在的分子靶点如ASD的表观遗传标记、ADHD的免疫改变和FASD的基因表达改变，突出了胎盘在不同情况下ndd中的特定作用。

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Placental alterations related to neurodevelopmental and associated disorders

Neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD) and attention deficit and hyperactivity disorder (ADHD), are conditions that are triggered during neurodevelopment in embryonic life and persist in postnatal life, leading to behavioral impairments. Despite the rising prevalence and extensive research, the mechanism behind the etiology of both disorders is not completely known. This narrative review explores the intricate interplay of genetic and environmental risk factors within the placenta, a pivotal transient organ crucial for fetal sustenance, and its role in the bidirectional passage of nutrients, gases, waste, hormones, and inflammatory mediators between the mother and fetus. We present a comprehensive overview of placental alterations associated with the diagnosis of NDDs (ASD and ADHD) and fetal alcohol spectrum disorders (FASD). Through this review, potential molecular targets emerged like epigenetic markers for ASD, immune alterations for ADHD, and altered gene expression for FASD, highlighting specific roles of the placenta in different contexts of NDDs

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.