Joint association of cognitive reserve and frailty with incident Alzheimer's disease and related dementias

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-07-15 DOI:10.1016/j.bbr.2025.115733

Yu-Ying Zhang , Bao-Lin Han , Ling-Zhi Ma , Liang-Yu Huang , Hai-Hua Guo , Shuang-Ling Han , Yin-Chu Mi , for the Alzheimer’s Disease Neuroimaging Initiative, Jia-Yao Liu , Ze-Hu Sheng , Lan Tan , Hui-Fu Wang

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引用次数: 0

Abstract

Cognitive reserve and frailty are factors associated with Alzheimer's disease and related dementias (ADRD). However, whether cognitive reserve and frailty interact to influence ADRD has not been explored well. We included 908 participants from the ADNI study. Our results suggested that cognitive reserve interacted with frailty to influence ADRD risk. High cognitive reserve was associated with lower ADRD risk in both non-frail and mildly frail participants (P value < 0.001), but the association was not observed in severely frail participants. Furthermore, mediation analysis showed that cognitive reserve influence dementia risk partly through the modulation of AD biomarkers in non-frail and mildly frail participants. Our study demonstrated that high cognitive reserve decreased the risk of ADRD by modulating AD pathology in non-frail and mildly frail participants.

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认知储备和虚弱与阿尔茨海默病和相关痴呆的联合关联。

认知储备和虚弱是与阿尔茨海默病和相关痴呆（ADRD）相关的因素。然而，认知储备和虚弱是否相互作用影响ADRD尚未得到很好的探讨。我们从ADNI研究中纳入了908名参与者。我们的研究结果表明，认知储备与虚弱相互作用影响ADRD风险。在非虚弱和轻度虚弱的参与者中，高认知储备与较低的ADRD风险相关（P值< 0.001），但在严重虚弱的参与者中没有观察到这种关联。此外，中介分析表明，认知储备部分通过调节非虚弱和轻度虚弱参与者的AD生物标志物来影响痴呆风险。我们的研究表明，在非虚弱和轻度虚弱的参与者中，高认知储备通过调节AD病理来降低ADRD的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.