Neuropsychobiology最新文献

{"title":"Indoleamine-2,3-dioxygenase and physical activity in bipolar disorder.","authors":"Julia Ilic, Frederike Fellendorf, Adelina Tmava-Berisha, Melanie Lenger, Susanne Bengesser, Tatjana Stross, Alexander Finner, Robert Queissner, Christian Miedl, Anna Pfannhofer, Nina Dalkner, Eva Reininghaus","doi":"10.1159/nps/adyag008","DOIUrl":"https://doi.org/10.1159/nps/adyag008","url":null,"abstract":"<p><p>Alterations in the tryptophan (TRP)-kynurenine (KYN) metabolism play an important role in the aetiopathogenesis of bipolar disorder (BD) and its obesity-related comorbidities. Physical activity has been suggested as a potential modulator of the indoleamine-2,3-dioxygenase, which regulates the metabolism of TRP towards KYN. This cross-sectional study explored differences in the KYN/TRP ratio, a proxy for indoleamine-2,3-dioxygenase, between patients with BD and healthy controls, stratified by level of physical activity. A total of 139 patients with BD and 76 controls were included. Physical activity was assessed using the International Physical Activity Questionnaire, and serum TRP and KYN levels were measured. Group differences in the KYN/TRP ratio depending on the level of physical activity (low-moderate, high) were examined using ANCOVA, controlling for age, sex, and body mass index (BMI). Results showed a significantly higher KYN/TRP ratio in patients with BD than in controls in the unadjusted comparison. After adjusting for sex, age and BMI, no statistically significant difference was observed in the KYN/TRP ratio for either group or for level of physical activity. In contrast, the interaction between age and group was significant, indicating that the age-related increase of the KYN/TRP ratio was stronger in patients with BD than in controls. However, this finding should be interpreted with caution and be considered as hypothesis-generating. The findings of the unadjusted data support previous results of altered TRP metabolism in BD but indicate that physical activity alone may not sufficiently modulate the KYN/TRP ratio. Future studies should consider longitudinal study designs, objective measures of physical activity and KYN downstream metabolites. Despite these findings, physical activity should remain a key component in the multimodal treatment of BD due to its benefits for physical and mental health.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1"},"PeriodicalIF":3.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of basal forebrain stimulation on regional blood flow and extracellular acetylcholine release in the piriform cortex.","authors":"Jura Moriya, Daichi Morihara, Fusako Kagitani, Sae Uchida","doi":"10.1159/nps/adyag007","DOIUrl":"https://doi.org/10.1159/nps/adyag007","url":null,"abstract":"<p><strong>Introduction: </strong>The piriform cortex receives substantial cholinergic innervation from neurons in the horizontal limb of the diagonal band of Broca (HDB) within the basal forebrain. This study investigated whether chemical stimulation of the HDB increases regional blood flow and extracellular acetylcholine (ACh) levels in the piriform cortex and whether the evoked hemodynamic response depends on cholinergic receptor activation.</p><p><strong>Methods: </strong>The experiments were performed on 15 adult male Fischer 344 rats. Under anesthesia, regional blood flow in the piriform cortex was measured using laser Doppler flowmetry. Extracellular ACh concentrations there were determined using microdialysis coupled with high-performance liquid chromatography and electrochemical detection (HPLC-ECD). Focal chemical stimulation of unilateral HDB was performed by microinjection of L-glutamate (50-100 nmol).</p><p><strong>Results: </strong>Following HDB stimulation with L-glutamate at doses of 50 and 100 nmol, regional blood flow in the ipsilateral piriform cortex increased to approximately 112% and 127% of prestimulus baseline levels, respectively. Mean arterial pressure was not significantly affected by HDB stimulation. In rats pretreated intravenously with the cholinergic receptor antagonists atropine and mecamylamine, HDB stimulation did not alter blood flow in the piriform cortex. HDB stimulation also increased extracellular ACh concentrations in the ipsilateral piriform cortex.</p><p><strong>Conclusion: </strong>This study showed that stimulation of HDB neurons in the basal forebrain increases regional blood flow in the piriform cortex, accompanied by an increase in ACh release in the same region, and that cholinergic receptor blockade abolishes this blood flow response. Impaired cholinergic input in this region may disrupt hemodynamic regulation, leading to olfactory dysfunction.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1"},"PeriodicalIF":3.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Element Concentrations in Bipolar Disorder: A Case-Control Analysis by ICP-MS.","authors":"Marina Brigitte Riemer, Tatjana Stross, Frederike Fellendorf, Melanie Lenger, Nina Dalkner, Adelina Tmava-Berisha, Alfred Häussl, Julia Ilic, Silvia Wehmeier, David Clases, Eva Reininghaus","doi":"10.1159/nps/adyag006","DOIUrl":"https://doi.org/10.1159/nps/adyag006","url":null,"abstract":"<p><p>Introduction Alterations in serum element concentrations have been proposed to contribute to the pathophysiology of psychiatric disorders. However, this association has not been thoroughly investigated in bipolar disorder (BD) and existing evidence remains inconsistent. This pilot study aimed to assess the relationship between the serum concentrations of essential trace elements (ETE) alkali metals (AM), alkaline earth metals (AEM) and non-essential elements in an euthymic sample of BD and healthy controls (HC) in order to identify both group- and sex-specific differences. Methods Serum levels of fourteen elements were quantified using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in eleven euthymic patients with BD and nine HC. Both groups showed no statistical significance regarding age, sex and BMI. Results Serum Magnesium levels (Mg: t(18) = 2.441, p = .025) were significantly elevated in individuals with BD (24.5 ± 1.7 mg L-1) compared to HC (22.9 ± 1.1 mg L-1). In addition, serum copper (Cu) concentrations were significantly higher in female participants relative to males (Cu: t(18) = 2.329, p = .032), independent of diagnostic group. Conclusion This pilot study observed elevated serum Mg concentrations in euthymic BD patients. While our findings suggest that Mg may contribute to the pathophysiology of BD, the small sample size, cross-sectional design, and inability to separate medication effects from disease effects limit interpretation. Therefore, further research is necessary to gain deeper insights into elemental alterations in BD and to clarify their clinical significance.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1"},"PeriodicalIF":3.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149112646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Trauma Clusters, Klotho, Matrix Metalloproteinase-9, and Cognitive Function in Adolescents with Major Affective Disorders.","authors":"Shao-Lun Ko, Ju-Wei Hsu, Ya-Mei Bai, Shih-Jen Tsai, Li-Chi Chen, Mu-Hong Chen","doi":"10.1159/000553593","DOIUrl":"https://doi.org/10.1159/000553593","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood trauma is common among adolescents with major affective disorders (MADs), including bipolar disorder and major depressive disorder. The relationships between childhood trauma subtypes, cognitive function, and the anti-aging protein Klotho and matrix metalloproteinase-9 (MMP-9) in adolescents with MADs remain unknown.</p><p><strong>Methods: </strong>We enrolled 95 adolescents with MADs (48 bipolar disorder, 47 major depressive disorder) and 45 healthy controls. Childhood trauma was assessed using the Childhood Trauma Questionnaire-Short Form. A k-means cluster analysis identified trauma-based subgroups among patients. Serum Klotho and MMP-9 levels and cognitive functions (working memory, Wisconsin Card Sorting Test, and Go/No-Go task) were assessed. Group differences were examined using generalized linear models adjusting for demographic variables, clinical symptoms, and medication use.</p><p><strong>Results: </strong>Three trauma clusters were identified: low trauma (n = 40), emotional neglect (EN)-focused (n = 47), and multi-trauma (n = 8) groups. The EN-focused group exhibited significantly lower Klotho levels than healthy controls and higher MMP-9 levels than all other groups. Cognitively, the EN-focused group showed reduced working memory accuracy and more trials to complete the first category on the Wisconsin Card Sorting Test, whereas the multi-trauma group demonstrated increased working memory errors and reduced Go/No-Go accuracy.</p><p><strong>Conclusion: </strong>Adolescents with EN-focused trauma displayed a distinct biological-cognitive profile characterized by lower serum Klotho, higher MMP-9, and executive dysfunction. These findings suggest that deprivation-related adversity may be associated with convergent Klotho-MMP-9 alterations and neurobiological vulnerability in MADs. Longitudinal studies are warranted to clarify causal mechanisms.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group-Dependent Associations Between Plasma Adiponectin and Hippocampal Subregional Volumes in Schizophrenia.","authors":"Chia-Chien Liu, Chen-Chia Lan, Yuan-Hwa Chou, Chenyi Chen, Yuan-Ju Chou, Yung-Tsan Jou, Shiow-Wen Yang, Wan-Yun Hsu, Li-Hung Chang, Yawei Cheng","doi":"10.1159/nps/adyag005","DOIUrl":"https://doi.org/10.1159/nps/adyag005","url":null,"abstract":"<p><strong>Introduction: </strong>Leptin and adiponectin are adipose-derived hormones that cross the blood-brain barrier and modulate hippocampal plasticity, neurogenesis, and inflammatory signaling. Dysregulated adipokine signaling may provide a biological link between systemic metabolic disturbances and hippocampal vulnerability in schizophrenia. This study investigated whether peripheral adipokines are associated with hippocampal subregional volumes in schizophrenia.</p><p><strong>Methods: </strong>Thirty-five patients with schizophrenia (SCZ) and 29 healthy controls (HCs) were enrolled in this cross-sectional study. Plasma leptin and adiponectin were quantified using ELISA. Longitudinal hippocampal subregions were delineated manually, and transverse subfields were segmented using FreeSurfer. Group differences in adipokines were assessed with Welch's t-tests. Hippocampal volumetric differences were examined using MANCOVAs followed by univariate ANCOVAs, adjusting for age, sex, body mass index (BMI), and estimated total intracranial volume (eTIV). Group-dependent adipokine-volume associations were evaluated using group × adipokine interaction models followed by group-stratified regression analyses.</p><p><strong>Results: </strong>Plasma leptin was significantly higher in SCZ than in HCs, whereas adiponectin showed a non-significant reduction. Patients with schizophrenia exhibited widespread hippocampal atrophy across both longitudinal and transverse subregions. Within the schizophrenia group, higher plasma adiponectin was associated with smaller hippocampal head volume, whereas no corresponding association was observed in healthy controls.</p><p><strong>Conclusion: </strong>Adiponectin-hippocampal associations appeared group-dependent within this sample. Higher plasma adiponectin was associated with smaller hippocampal head volume in schizophrenia but not in healthy controls, supporting further investigation of metabolic-neural relationships in larger longitudinal and mechanistic studies.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1"},"PeriodicalIF":3.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating glutamate and incident metabolic syndrome during antidepressant treatment in major depressive disorder.","authors":"Khalil El Asmar, Tala El Ghoul, Romain Colle, Rida Assaf, Séverine Martin, Séverine Trabado, Bruno Fève, Céline Verstuyft, Laurent Becquemont, Emmanuelle Corruble","doi":"10.1159/nps/adyag003","DOIUrl":"https://doi.org/10.1159/nps/adyag003","url":null,"abstract":"<p><strong>Background: </strong>Metabolic Syndrome (MetS) is increasingly prevalent worldwide, raising the risk of diabetes and cardiovascular diseases. Glutamate, a key excitatory neurotransmitter involved in depression and antidepressant response, is also implicated in metabolic dysregulation ; whereas glutamine/glutamate ratio, reflecting the balance between neurotransmission and metabolism, may provide additional insight into this relationship. This study prospectively examines the associations of blood glutamate levels and the glutamine/glutamate ratio with MetS in depressed patients treated with antidepressants for six months.</p><p><strong>Methods: </strong>In the METADAP cohort, 164 non-overweight patients with major depressive disorder were evaluated for blood glutamate and glutamine levels at baseline, three months (M3), and six months (M6) after initiating antidepressant treatment. Logistic and linear regression models were used to explore associations between glutamate levels, the glutamine/glutamate ratio, MetS incidence, its individual components, and insulin resistance. The cut-off threshold was internally validated using 1,000 bootstrap resamples with optimism correction.</p><p><strong>Results: </strong>Glutamate levels decreased significantly over time. Higher odds of MetS were observed with elevated glutamate at M3 [OR = 1.032, 95% CI 1.01-1.06, p = 0.001] and with smaller reduction from baseline [OR = 1.03, 95% CI 1.028-1.034, p < 0.001]. Glutamate levels above 38 µmol/L at M3 tripled the risk of developing MetS [OR = 3.24, 95% CI 1.83-5.72, p < 0.001]. Similar trends were observed for the glutamine/glutamate ratio, supporting its value as a complementary metabolic marker. Similar trends were observed for the glutamine/glutamate ratio, supporting its value as a complementary metabolic marker.</p><p><strong>Conclusions: </strong>Monitoring circulating glutamate levels and the glutamine/glutamate ratio at month 3 may help identify patients at higher metabolic risk during antidepressant treatment and support increased clinical vigilance with respect to metabolic outcomes.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1"},"PeriodicalIF":3.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Soluble Triggering Receptor Expressed on Myeloid Cells-1 and -2 and Fractalkine in Depression and Childhood Adversity: An Exploratory Study.","authors":"An Bin Cho, Christian Otte, Carsten Spitzer, Berk Uesekes, Linn K Kuehl, Julian Hellmann-Regen, Katja Wingenfeld","doi":"10.1159/nps/adyag002","DOIUrl":"10.1159/nps/adyag002","url":null,"abstract":"<p><strong>Introduction: </strong>Adverse childhood experiences (ACEs) and major depressive disorder (MDD) are associated with altered inflammatory processes, dysregulation of the hypothalamic-pituitary-adrenal axis and an increased risk of developing metabolic diseases. Soluble Triggering Receptor Expressed on Myeloid Cells-1 and -2 (sTREM1, sTREM2) and Fractalkine (CX3CL1) are markers of the innate immune system regulating inflammatory response but are relatively underexplored in ACE and MDD.</p><p><strong>Methods: </strong>In this exploratory study, we measured serum sTREM1, sTREM2, CX3CL1, and pro-inflammatory cytokines in 23 women with ACE and MDD, 23 women with MDD without ACE, 22 healthy women with ACE with no current or lifetime MDD and 25 healthy women with neither ACE nor MDD. Additionally, explorative correlations between levels of sTREM1, sTREM2, CX3CL1, and cytokines, measures of trauma, depressive symptoms, anxiety, self-reported stress, metabolic parameters, and cortisol release were calculated.</p><p><strong>Results: </strong>The four groups in this study did not differ in levels of sTREM1 and sTREM2. Healthy women without ACE had higher CX3CL1 concentrations than both depression groups. They also had lower IL-8 and IL-18 levels than each of the other three groups (ACE+/MDD+, ACE-/MDD+, and ACE+/MDD-). sTREM1 and CX3CL1 were related to pro-inflammatory activity, such as TNF-α and NGF, while sTREM2 was associated with an increased metabolic risk. Furthermore, CX3CL1 correlated with lower stress ratings and a higher cortisol release to psychosocial stress induction, while sTREM2 correlated positively with symptoms of depression and anxiety.</p><p><strong>Conclusion: </strong>Lower CX3CL1 and increased cytokines might be an unspecific correlate of mental disorders and early traumatic experiences. sTREM1, sTREM2, and CX3CL1 seem to be associated with somatic as well as mental health variables. Further studies are needed to investigate the specific role of sTREM1, sTREM2, and CX3CL1 in the interplay between physical and mental health.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1"},"PeriodicalIF":3.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Therapy for Autism Spectrum Disorder: Preclinical Advances, Translational Barriers, and Ethical Dimensions - A Scoping Review.","authors":"Ali Naderi Malek, Amir Hossein Rasoli Jokar, Patricia Prelock","doi":"10.1159/000552956","DOIUrl":"10.1159/000552956","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) lacks disease-modifying therapies. Gene therapy offers a promising approach for targeting the molecular mechanisms underlying ASD, particularly in monogenic or syndromic forms in which single-gene mutations play a central role.</p><p><strong>Summary: </strong>A scoping review was conducted following the PRISMA-ScR framework. PubMed, Scopus, Web of Science, PsycINFO, and the Cochrane Library were searched for studies published from 2000 to July 2025. Eligible studies included preclinical or translational investigations of gene-therapy modalities, such as adeno-associated viral vectors, antisense oligonucleotides, and CRISPR-based editing, targeting high-confidence ASD-linked genes. Non-gene-therapy studies, unrelated conditions, reviews, and non-English publications were excluded. Data were extracted using a standardized form and synthesized descriptively across two evidence streams. Stream 1 examined preclinical studies of gene therapy, and Stream 2 addressed translational advances and ethical issues. Twenty-one preclinical studies were identified in Stream 1, focusing on genes including UBE3A, MECP2, FMR1, SHANK3/2, SCN2A, and SYNGAP1. Most studies reported molecular correction and improvements in synaptic, electrophysiological, and behavioral outcomes, with therapeutic effects observed from early developmental to adult stages. Stream 2 included 12 studies highlighting translational barriers such as delivery challenges, safety concerns, and ethical issues related to pediatric consent, neurodiversity, and equity of access. Important limitations included heterogeneity across models, reliance on rodent studies, and the lack of completed human clinical trials.</p><p><strong>Key messages: </strong>Gene therapy for ASD shows substantial promise, especially for genetically defined forms of the condition, but major translational and ethical challenges remain. Future progress will depend on more standardized preclinical designs, stronger safety evaluation, and transparent engagement with stakeholders to support responsible clinical translation.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-17"},"PeriodicalIF":3.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gray Matter Structural Asymmetry and Premenstrual Dysphoric Disorder.","authors":"Elise Bücklein-Ehlers, Manon Dubol, Birgit Derntl, Melanies Henes, Ann-Christine Ehlis, Thomas Dresler, Inger Sundström-Poromaa, Andreas Fallgatter, Erika Comasco","doi":"10.1159/000553663","DOIUrl":"10.1159/000553663","url":null,"abstract":"<p><strong>Introduction: </strong>Left-right brain asymmetry is an important feature of human neuroanatomy, with implications for cognition, behavior, and vulnerability to mental disorders. Despite evidence for lateralized brain sensitivity to hormonal fluctuations, the cortical and subcortical asymmetry profile of individuals with premenstrual dysphoric disorder (PMDD), a hormone-related mood disorder associated with alterations in brain structure, remains unexplored.</p><p><strong>Methods: </strong>In this study, a total of 68 females with PMDD and 51 healthy females underwent magnetic resonance imaging during the luteal phase of the menstrual cycle. Structural asymmetry was assessed using voxel-wise whole-brain analysis and region of interest (ROI) approaches for gray matter volume (GMV), as well as ROI-based analysis of cortical thickness. Associations between asymmetry and symptom severity were also investigated.</p><p><strong>Results: </strong>Whole-brain analyses revealed significantly greater leftward GMV asymmetry in PMDD participants in two clusters within the anterior fusiform gyrus and the anterior insula. ROI-based analyses did not show any asymmetry group differences in either GMV or cortical thickness. Within the PMDD group, greater leftward asymmetry in the amygdala GMV was moderately associated with higher irritability.</p><p><strong>Conclusion: </strong>These findings provide novel, region-specific evidence for structural asymmetry in PMDD and suggest that lateralized brain architecture may contribute to affective symptom expression in this disorder.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-12"},"PeriodicalIF":3.7,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of Cortisol in Cognitive Impairment Observed in Cancer Patients: A Systematic Review.","authors":"Ángel Rodríguez-Ramos, Raquel Espejo-Siles, Ana Belén Castillo-Miranda, Francisco García-Torres","doi":"10.1159/000553504","DOIUrl":"10.1159/000553504","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer-related cognitive impairment (CRCI) is a frequent adverse effect observed in patients, but the underlying mechanisms are still unclear. Cortisol has been proposed as a potential contributor to CRCI, so the aim of this review was to systematically evaluate the evidence on the role of cortisol in CRCI.</p><p><strong>Methods: </strong>This review followed PRISMA guidelines and was registered in PROSPERO (CRD42024570561). The search was conducted in PubMed, Web of Science, SCOPUS, ProQuest, OSF PREPRINTS, OATD, NDLTD Global E-Theses and Dissertations, and EBSCO. Inclusion criteria were studies on adult cancer patients/survivors assessing cortisol and CRCI, published in English from inception to January 30, 2025. The risk of bias was analyzed with the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, and a qualitative GRADE-like summary of the certainty of the evidence.</p><p><strong>Results: </strong>Twelve articles were finally included and analyzed using content analysis methods. Overall, findings suggest that altered diurnal cortisol rhythm (i.e., blunted cortisol secretion pattern) might be involved in CRCI; although results are inconsistent and the exact mechanisms remain unknown. Stress response associated to diagnosis, surgery, and life changes, as well as certain treatments, of cancer patients may contribute to dysregulated cortisol secretion, which in turn has been linked to CRCI. Additionally, personality traits and sociodemographic factors may act as mediators between cortisol release and CRCI.</p><p><strong>Conclusion: </strong>Recent data suggest cortisol relates to CRCI; however, future research should standardize cognitive outcomes and cortisol assessment methods, and consider clinical, sociodemographic, and psychological factors that may modulate stress responses.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-16"},"PeriodicalIF":3.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}