Neuropsychobiology最新文献

{"title":"Oxidative stress markers predict treatment outcomes in patients with generalized anxiety disorder treated with selective serotonin reuptake inhibitors.","authors":"Lijun Cui, Jingjing Lu, Zhongxia Shen, Jielin Zhu, Huanxin Chen, Shenliang Yang, Shikai Wang, Xinhua Shen","doi":"10.1159/000544963","DOIUrl":"https://doi.org/10.1159/000544963","url":null,"abstract":"<p><strong>Introduction: </strong>The etiology of generalized anxiety disorder (GAD) has not been fully understood, and oxidative stress may potentially contribute to its pathogenesis. However, there is no published evidence concerning the possible influence of oxidative stress on antidepressant treatment outcomes. This study investigated the ability of oxidative stress markers to predict treatment outcomes in GAD patients treated with selective serotonin reuptake inhibitors (SSRIs).</p><p><strong>Methods: </strong>One hundred-one GAD patients and 100 healthy controls (HCs) were included in this study. The 101 GAD patients were selected for treatment with escitalopram (n=52) or sertraline (n=49) for eight weeks. Hamilton Anxiety Rating Scale (HAM-A) assessments were conducted before and after treatment. The serum levels of eight oxidative stress makers, malondialdehyde (MDA), lipid hydroperoxides (LPO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), cortisol, high-density lipoprotein (HDL), and nitric oxide (NO) were measured using enzyme-linked immunosorbent assays (ELISA) before and after SSRI treatment in GAD patients and at the time of HCs enrollment.</p><p><strong>Results: </strong>The serum levels of MDA, cortisol, and LPO were higher in GAD patients than in HCs (all p<.001), while SOD, GSH-Px, and CAT were lower than in HCs (all p<.001). The baseline MDA, LPO, NO, and cortisol levels were positively correlated with anxiety severity, while GSH-Px was negatively correlated. After eight weeks of SSRI treatment, the GSH-Px levels increased, and MDA and LPO decreased (all p<.05). Alterations in MDA levels co-varied with changes in anxiety measures (all p<.05). The ability of the receiver operating characteristic (ROC) area of the baseline MDA levels to predict the SSRI endpoint treatment response was 0.804 (p<.05).</p><p><strong>Conclusion: </strong>The pathogenesis of GAD might involve oxidative stress. Moreover, serum MDA levels might predict treatment response to SSRIs. However, more research is warranted to confirm these findings.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-19"},"PeriodicalIF":2.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forced running attenuates depression-like behavior and hippocampal inflammatory response in mice induced by Chronic Unpredictable Mild Stress.","authors":"Qian Zhong, Mengqi Duan","doi":"10.1159/000544843","DOIUrl":"https://doi.org/10.1159/000544843","url":null,"abstract":"<p><strong>Introduction: </strong>As a late proinflammatory factor, the role of High mobility group box 1 (HMGB-1) in nervous system inflammation has been widely studied. The inflammatory response mediated by HMGB-1 plays an important role in the pathophysiological mechanism of depression. This study aimed to investigate the antidepressant effects of forced running on chronic unpredictable mild stress (CUMS) mice by examining the impact on hippocampal HMGB-1.</p><p><strong>Methods: </strong>The experiment included a comparison with the traditional broad-spectrum antidepressant fluoxetine to evaluate the potential benefits of forced exercise or combined therapy. Mice were divided into different groups - control, forced running + fluoxetine (FR+FLU), CUMS, CUMS + forced running (CUMS+FR), CUMS + fluoxetine (CUMS+FLU), and CUMS + forced running + fluoxetine combined therapy (CUMS+FR+FLU). The study used the tail suspension test (TST), forced swimming test (FST), and sucrose preference test (SPT) to assess depression-like behavior. Following the experiment, the levels of hippocampal HMGB-1 and associated proteins and cytokines were measured.</p><p><strong>Results: </strong>The results revealed that four weeks of forced running significantly attenuated depression-like behavior and reduced the expression of HMGB-1-associated inflammatory proteins and cytokines in CUMS mice. Conversely, fluoxetine showed limited effectiveness in reversing depression-like behavior but demonstrated a reduction in the expression of hippocampal HMGB-1-associated inflammatory proteins and cytokines. The combined therapy also exhibited significant antidepressant effects and reduced levels of HMGB-1-associated inflammatory proteins and cytokines, with a faster response compared to forced running alone.</p><p><strong>Conclusion: </strong>Forced running may offer potential benefits in modulating the anti-inflammatory response associated with HMGB-1, providing insights into the potential therapeutic role of physical exercise in managing depression.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-22"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an App-Based Resilience Training on Enhancing Stress Regulation and Mental Health.","authors":"Melanie Lenger, Elena M D Schönthaler, Alina Hantke, Nina Dalkner, Suher Guggemos, Martin Pszeida, Jochen A Mosbacher, Sandra Draxler, Thomas Lutz, Silvia Russegger, Jama Nateqi, Dietrich Albert, Lucas Paletta, Eva Z Reininghaus","doi":"10.1159/000544149","DOIUrl":"10.1159/000544149","url":null,"abstract":"<p><strong>Introduction: </strong>Recent research suggests various app-based-programs to promote mental health, resilience, and stress management. Insights gained from studies with healthy participants could potentially offer training strategies that could also prove beneficial for people with mental disorders. The effectiveness of an app-based resilience training was evaluated.</p><p><strong>Methods: </strong>In the present study, 68 mentally healthy participants were included. They all received both the intervention as 2-month resilience training via an app and the control condition (waiting group) as part of a crossover design. In addition, the participants were interviewed before, and after each condition with the Stress and Coping Inventory (SCI), the Brief Symptom Inventory (BSI), and the Resilience Scale (RS13), measuring psychological stress and symptoms.</p><p><strong>Results: </strong>The results of the analyses of co-variance indicate that the app-training does not significantly improve resilience in healthy people (p = 0.278). However, it significantly enhances stress regulation in the intervention group and the control group (p = 0.030), independent of the initial stress level. Furthermore, a significant positive correlation was found between effective stress regulation and improved mental health (measured by the BSI).</p><p><strong>Conclusion: </strong>Emphasizing mindfulness and reflection through resilience training and the enhanced perception of mental health, can improve stress regulation, thereby underscoring its crucial role. To maximize the benefits of resilience training, it is imperative to further develop training apps, enhancing their attractiveness and suitability for long-term use, and extend its use. Future work should focus on refining these interventions to ensure sustained engagement and effectiveness.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-12"},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Annotation of Bipolar Disorder 2 Risk Location Implicates Novel Susceptibility Genes.","authors":"Güneş Şayan Can, Ebru Bakır, Yavuz Oktay","doi":"10.1159/000543504","DOIUrl":"10.1159/000543504","url":null,"abstract":"<p><strong>Introduction: </strong>Bipolar 2 disorder (BD2) is an independent disease with specific familial aggregation, significant functional impairment, specific treatment challenges, and several distinctive clinical features. However, unlike bipolar 1 disorder, studies investigating causal and functional genes are lacking. This study aimed to identify and prioritize causal genetic variants and genes for BD2 by analysing brain-specific gene expression markers, improve the understanding of its genetic underpinnings, and support advancements in diagnosis, treatment, and prognosis.</p><p><strong>Method: </strong>We used FUMA, a genome-wide association study (GWAS) annotation tool, to pinpoint potential causal variants and genes from the largest BD2 GWAS data. Candidate causal variants most likely affecting brain gene expression were prioritized using the following criteria: (1) variants identified as eSNPs in any brain region within any brain expression quantitative trait loci (eQTL) dataset; (2) variants annotated in the Regulome database with a score <5, indicating likely functional localization; (3) the most common 15-core chromatin state across all cell types in the Roadmap Epigenomics data being ≤7, reflecting an open chromatin state; (4) localization in genomic regions with evidence of 3D chromatin interactions, as such interactions mediate genetic effects on gene expression.</p><p><strong>Results: </strong>We identified AGRN, ORMDL3, SLC25A39, RUNDC3A, NOS2, C1orf159, RP11-5407.18, RP11-465B22.3, RP11-5407.17 as candidate causal genes. These genes are associated with important pathways such as synapse formation, mitochondrial and oxidative metabolism, intracellular transport, neurotransmission, and lipid metabolism-related pathways.</p><p><strong>Conclusion: </strong>This study provides a guide for further experimental validation of functional variants, BD2-associated genes, and novel drug targets.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"65-73"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Mediators of the Association between Obesity and Symptoms of Depression, Anxiety, and Stress.","authors":"Joana Henriques, Vera Afreixo, Human Unterrainer, Hugo Senra","doi":"10.1159/000542767","DOIUrl":"10.1159/000542767","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;There is still paucity of knowledge about which factors can mediate the link between obesity and mental health problems. This study aimed to investigate psychological mediators of the association between different weight profiles (healthy, overweight, and obesity) and symptoms of depression, anxiety, and stress.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A sample of 407 adults (≥18 years old) with different weight profiles recruited from general population was assessed for symptoms of depression, anxiety, and stress, and dimensions of emotion regulation and body investment/body image. Robust regression and robust mediation analyses were employed to investigate predictors and mediators of mental health outcomes in relation to different weight profiles.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Body investment difficulties in relation to body image and body care, and emotion regulation difficulties related to a tendency towards negative secondary responses to negative emotions, and/or denial of distress, significantly mediated the association between obesity and symptoms of depression. The association between obesity and symptoms of anxiety and stress was significantly mediated by body investment difficulties related to body image concerns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The current study brings evidence on specific dimensions of emotion regulation and body image that play a key role for the co-occurrence of mental health problems in individuals with obesity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;There is still paucity of knowledge about which factors can mediate the link between obesity and mental health problems. This study aimed to investigate psychological mediators of the association between different weight profiles (healthy, overweight, and obesity) and symptoms of depression, anxiety, and stress.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A sample of 407 adults (≥18 years old) with different weight profiles recruited from general population was assessed for symptoms of depression, anxiety, and stress, and dimensions of emotion regulation and body investment/body image. Robust regression and robust mediation analyses were employed to investigate predictors and mediators of mental health outcomes in relation to different weight profiles.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Body investment difficulties in relation to body image and body care, and emotion regulation difficulties related to a tendency towards negative secondary responses to negative emotions, and/or denial of distress, significantly mediated the association between obesity and symptoms of depression. The association between obesity and symptoms of anxiety and stress was significantly mediated by body investment difficulties related to body image concerns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The current study brings evidence on specific dimensions of emotion regulation and body image that play a key role for the co-occurrence of mental health problems in individuals with obesit","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"26-37"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Childhood Trauma and Anxiety on the Hypothalamic-Pituitary-Adrenal Axis in Chronic Subjective Tinnitus with Distress.","authors":"Laura Lucia Maria Cassiers, Filip Van Den Eede, Koen Schruers, Annick Gilles, Vincent Van Rompaey, Bernard G C Sabbe","doi":"10.1159/000542066","DOIUrl":"10.1159/000542066","url":null,"abstract":"<p><strong>Introduction: </strong>There is some evidence for hypothalamic-pituitary-adrenal (HPA) axis hypofunction in chronic tinnitus, but findings are contradicting possibly due to clinical heterogeneity. This study aimed to assess differential effects of childhood trauma and anxiety on HPA-axis functioning in adults suffering from chronic subjective tinnitus with distress.</p><p><strong>Methods: </strong>Salivary cortisol data were collected in 22 chronic subjective tinnitus sufferers (without major depression) and 29 healthy controls after awakening, at baseline, and after a low-dose (0.5 mg) dexamethasone challenge. A factorial ANCOVA was conducted to compare the main effects of group (tinnitus versus. controls), trauma, and their interaction effect on the cortisol awakening response (CAR). Linear mixed models were fitted for baseline and post-dexamethasone cortisol levels with group, sampling time, trauma, and their interactions as fixed factors and subject as the random effect. The Beck Anxiety Index, Anxiety Sensitivity Index, and Panic Disorder Severity Scale were included to investigate effects of anxiety.</p><p><strong>Results: </strong>A significant interaction between group and trauma (F [1, 47] = 6.9755, p = 0.0112) was found, with the tinnitus group showing lower CARs (M = 5.1808, SD = 0.5821) than the comparison group (M = 5.9974, SD = 0.5251) in traumatized individuals only. No effects were found for baseline or post-dexamethasone cortisol. Anxiety scores had no effects on any of the outcome variables.</p><p><strong>Conclusion: </strong>A differential effect of childhood trauma, but not anxiety, on the HPA-axis function in chronic subjective tinnitus was partly confirmed by the finding of a blunted CAR in tinnitus sufferers reporting early-life adversity.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"15-25"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review.","authors":"Elena M D Schönthaler, Haleh Aminfar, Nina Dalkner, Frederike T Fellendorf, Johanna Georgi, Melanie Lenger, Andreas Wedrich, Eva Z Reininghaus","doi":"10.1159/000543290","DOIUrl":"10.1159/000543290","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Bipolar disorder (BD) is a psychiatric condition with significant health implications due to its comorbidities, premature mortality, and functional impairments. Despite extensive research on treatment and rehabilitation, gaps remain in diagnosis and monitoring. Therefore, there is a need for biomarkers to identify individuals at risk for disease progression or exacerbation. Developmentally part of the central nervous system, the retina represents a possible marker for observing BD-related structural and functional alterations in the brain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary: &lt;/strong&gt;The retina's structure can be assessed through optical coherence tomography (OCT), a noninvasive and cost-effective method. Retinal alterations, particularly in the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), have been associated with neurodegenerative and psychiatric disorders in cross-sectional OCT studies. This scoping review discusses findings on retinal changes in BD as well as their association with disease characteristics like symptom severity and illness duration and highlights OCT as a potential diagnostic tool in BD treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key findings: &lt;/strong&gt;The majority of studies indicate RNFL and GCL thinning in BD patients, which was found to correlate with clinical characteristics in some studies. Although the data are currently limited, there is a possibility that retinal biomarkers could facilitate monitoring of BD, but more research needs to be conducted to observe the relationship between these parameters and BD. Moreover, other factors (e.g., treatment, metabolic and inflammatory conditions) may impact retinal changes, which highlights the need for longitudinal studies to clarify these relationships. Further research should focus on replicating current findings, understanding the role of inflammation, and differentiating between retinal regions affected by BD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Bipolar disorder (BD) is a psychiatric condition with significant health implications due to its comorbidities, premature mortality, and functional impairments. Despite extensive research on treatment and rehabilitation, gaps remain in diagnosis and monitoring. Therefore, there is a need for biomarkers to identify individuals at risk for disease progression or exacerbation. Developmentally part of the central nervous system, the retina represents a possible marker for observing BD-related structural and functional alterations in the brain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary: &lt;/strong&gt;The retina's structure can be assessed through optical coherence tomography (OCT), a noninvasive and cost-effective method. Retinal alterations, particularly in the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), have been associated with neurodegenerative and psychiatric disorders in cross-sectional OCT studies. This scoping review discusses findings on retinal changes in BD as well as their association with disease characteristic","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"100-112"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Childhood Experiences Are Associated with Mental Health Problems Later in Life: An Umbrella Review of Systematic Review and Meta-Analysis.","authors":"Biruk Beletew Abate, Ashenafi Kibret Sendekie, Abebe Merchaw, Gebremeskel Kibret Abebe, Molla Azmeraw, Addis Wondmagegn Alamaw, Alemu Birara Zemariam, Tegene Atamenta Kitaw, Amare Kassaw, Tilahun Wodaynew, Ayelign Mengesha Kassie, Gizachew Yilak, Mulat Awoke Kassa","doi":"10.1159/000542392","DOIUrl":"10.1159/000542392","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Evidence suggested a link between early adversity and mental health problems. However, it is unclear how much adverse childhood experiences (ACEs) contribute to mental health problems because researchers have produced inconsistent findings. Therefore, the objective of this umbrella review was to combine the contradictory data regarding the effect of ACEs on the development of mental health problems later in life in the global context.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;PubMed, Embase, Scopus, Web of Sciences, Cochrane Database of Systematic Reviews, Scopus, and Google Scholar which reported the effect of ACEs on the development of mental health problems was searched. The quality of the included studies was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR). A weighted inverse variance random-effects model was applied to find the pooled estimates. The subgroup analysis, heterogeneity, publication bias, and sensitivity analysis were also assessed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Forty-three SRM with 14,707,614 study participants were included. The pooled effect of ACEs on the development of mental health problems later in life in the global context is found to be (AOR = 1.66 [1.46, 1.87]). Subgroup analysis based on country revealed (AOR = 1.67 [1.23, 2.11]) in UK, (AOR = 0.61 [0.41, 0.81]) in Canada, (AOR = 1.55 [1.40, 1.69]) in Brazil, (AOR = 5.65 [4.12, 7.18]) in Ethiopia, (AOR = 1.92 [1.45, 2.38]) in USA, (AOR = 2.30 [1.89, 2.72]) in Australia, and (AOR = 1.66 [1.46, 1.87]) in Ireland. While subgroup analysis based on types of adverse childhood adverse experience: domestic violence (AOR = 4.13 [1.96, 6.30]), maltreatment (AOR = 1.5 [0.79, 2.21]), physical abuse (AOR = 1.56 [1.43, 1.63]), sexual abuse (AOR = 2.07 [1.63, 2.51]), child abuse (AOR = 5.66 [4.12, 7.18]), parental mental health problem (AOR = 1.73 [1.39, 2.08]), bullying (AOR = 1.99 [1.69, 2.29], neglect (AOR = 2.11 [1.53, 2.69]), and parental divorce (AOR = 1.66 [1.46, 1.87]). Based on the type of mental health problem, the pooled effect size is 1.87 (1.45, 2.30) for depression and 1.67 (1.22, 2.13) for anxiety.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This umbrella review revealed that ACE is significantly associated (with 66% increased risk) with anxiety and depression later in life in a global context. This association is most noticeable when one is subjected to domestic violence, maltreatment, physical abuse, sexual abuse, child abuse, parental mental health problems, bullying, neglect, and parental divorce. Childhood periods are a critical window of opportunity for reducing the risk of developing mental illness in the future and for implementing intervention measures. Preventing childhood maltreatment and addressing psychiatric risk factors can prevent psychopathology. Longitudinal studies are needed to optimize healthcare responses to ACEs. Increased awareness and public health interventions are needed to prevent childhood adversity a","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"48-64"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiome in Impulsively Violent Female Convicts.","authors":"Michaela Langmajerová, Janet Ježková, Jakub Kreisinger, Jaroslav Semerád, Ivan Titov, Petra Procházková, Tomáš Cajthaml, Václav Jiřička, Jan Vevera, Radka Roubalová","doi":"10.1159/000542220","DOIUrl":"10.1159/000542220","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Impulsivity and aggression are often interlinked behavioral traits that have major implications for our society. Therefore, the study of this phenomenon and derivative interventions that could lead to better control of impulsive aggression are of interest.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We analyzed the composition and diversity of the gut bacterial microbiome of 33 impulsively violent female convicts with dissocial personality disorder and 20 non-impulsive age-matched women. Further, levels of assorted neurotransmitters and short-chain fatty acids (SCFAs) were analyzed in serum and stool samples. We also assessed all participants using a battery of psychological questionnaires and tested possible correlations between the collected clinical data and the composition and diversity of their microbiomes and metabolites.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We identified four bacterial amplicon sequencing variants that were differentially abundant in non-impulsive versus impulsive women - the genera Bacteroides, Barnesiella, and the order Rhodospirillales were more abundant in impulsive women. In contrast, the genus Catenisphaera was more abundant in non-impulsive women. Fecal tryptophan levels were significantly higher in impulsive women. Association analysis revealed a strong positive intercorrelation between most fecal SCFAs in the entire dataset.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our study demonstrated possible associations between gut microbiomes and their metabolites and impulsive behavior in a unique cohort of prisoners convicted of violent assaults and a matched group of non-impulsive women from the same prison. Genus Bacteroides, which was differentially abundant in the two groups, encoded enzymes that affect serotonin pathways and could contribute to this maladaptive behavior. Similarly, increased fecal tryptophan levels in impulsive individuals could affect neuronal circuits in the brain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Impulsivity and aggression are often interlinked behavioral traits that have major implications for our society. Therefore, the study of this phenomenon and derivative interventions that could lead to better control of impulsive aggression are of interest.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We analyzed the composition and diversity of the gut bacterial microbiome of 33 impulsively violent female convicts with dissocial personality disorder and 20 non-impulsive age-matched women. Further, levels of assorted neurotransmitters and short-chain fatty acids (SCFAs) were analyzed in serum and stool samples. We also assessed all participants using a battery of psychological questionnaires and tested possible correlations between the collected clinical data and the composition and diversity of their microbiomes and metabolites.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We identified four bacterial amplicon sequencing variants that were differentially abundant in non-impulsive versus impulsive women - the genera","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-14"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The St. Göran Project: A Multipronged Strategy for Longitudinal Studies for Bipolar Disorders.","authors":"Mikael Landén, Lina Jonsson, Anna Luisa Klahn, Mathias Kardell, Andreas Göteson, Christoph Abé, Andreas Aspholmer, Benny Liberg, Aurimantas Pelanis, Timea Sparding, Erik Pålsson","doi":"10.1159/000543335","DOIUrl":"10.1159/000543335","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The St. Göran Bipolar Project (SBP) is a longitudinal outpatient study investigation aimed at identifying predictive factors associated with long-term outcomes in individuals with bipolar disorder. These outcomes include cognitive function, relapse rate, treatment responses, and functional outcomes. The study employs a multifaceted approach, integrating brain imaging, biochemical analyses of cerebrospinal fluid and blood, and genetics. This paper provides an overview of the research methods used in the SBP, along with a summary of the main findings to date.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;SBP is a collaborative effort between academia and healthcare, enrolling study participants from bipolar outpatient clinics in Stockholm (SBP-S) and Gothenburg (SBP-G), Sweden. Healthy controls were recruited through Statistics Sweden. Data and samples were collected using structured interviews, self-rated questionnaires, blood and cerebrospinal fluid samples, magnetic resonance imaging, and neuropsychological tests. Follow-up visits are conducted 7 and 14 years after baseline.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The SBP has generated numerous original findings and has contributed to advancing knowledge on cognitive function, personality, cerebrospinal and blood biomarkers, neuroimaging, and genetics. Further, as data collection nears completion, new research questions can be addressed. The study's strengths include detailed, multimodal information from each study visit and a long follow-up period. The naturalistic setting ensures that findings are relevant to real-world scenarios. However, variability in data completeness can introduce selection bias. Additionally, the control population, while randomly selected, may not be fully representative due to the voluntary nature of participation. Future projects will focus on longitudinal analyses and novel methods to exploit the study's multifaceted approach.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The St. Göran Bipolar Project (SBP) is a longitudinal outpatient study investigation aimed at identifying predictive factors associated with long-term outcomes in individuals with bipolar disorder. These outcomes include cognitive function, relapse rate, treatment responses, and functional outcomes. The study employs a multifaceted approach, integrating brain imaging, biochemical analyses of cerebrospinal fluid and blood, and genetics. This paper provides an overview of the research methods used in the SBP, along with a summary of the main findings to date.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;SBP is a collaborative effort between academia and healthcare, enrolling study participants from bipolar outpatient clinics in Stockholm (SBP-S) and Gothenburg (SBP-G), Sweden. Healthy controls were recruited through Statistics Sweden. Data and samples were collected using structured interviews, self-rated questionnaires, blood and cerebrospinal fluid samples, magnetic resonance imaging, and neuropsychologica","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"86-99"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}