Effects of childhood trauma and anxiety on the hypothalamic-pituitary-adrenal axis in chronic subjective tinnitus with distress.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2024-11-21 DOI:10.1159/000542066

Laura Lucia Maria Cassiers, Filip Van Den Eede, Koen Schruers, Annick Gilles, Vincent Van Rompaey, Bernard G C Sabbe

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引用次数: 0

Abstract

Introduction: There is some evidence for hypothalamic-pituitary-adrenal (HPA) axis hypofunction in chronic tinnitus, but findings are contradicting possibly due to clinical heterogeneity. This study aims to assess differential effects of childhood trauma and anxiety on HPA-axis functioning in adults suffering from chronic subjective tinnitus with distress.

Methods: Salivary cortisol data were collected in 22 chronic subjective tinnitus sufferers (without major depression) and 29 healthy controls after awakening, at baseline and after a low-dose (0.5 mg) dexamethasone challenge. A factorial ANCOVA was conducted to compare the main effects of group (tinnitus versus controls), trauma and their interaction effect on the cortisol awakening response (CAR). Linear mixed models were fitted for baseline and post-dexamethasone cortisol levels with group, sampling time, trauma and their interactions as fixed factors and subject as the random effect. The Beck Anxiety Index, Anxiety Sensitivity Index and Panic Disorder Severity Scale were included to investigate effects of anxiety.

Results: A significant interaction between group and trauma (F(1, 47) = 6.9755, p = 0.0112) was found, with the tinnitus group showing lower CARs (M = 5.1808, SD = 0.5821) than the comparison group (M = 5.9974; SD = 0.5251) in traumatised individuals only. No effects were found for baseline or post-dexamethasone cortisol. Anxiety scores had no effects on any of the outcome variables.

Conclusion: A differential effect of childhood trauma, but not anxiety, on the HPA-axis function in chronic subjective tinnitus was partly confirmed by the finding of a blunted CAR in tinnitus sufferers reporting early-life adversity.

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童年创伤和焦虑对慢性主观性痛苦耳鸣患者下丘脑-垂体-肾上腺轴的影响。

导言：有证据表明慢性耳鸣患者的下丘脑-垂体-肾上腺（HPA）轴功能低下，但可能由于临床异质性，研究结果相互矛盾。本研究旨在评估童年创伤和焦虑对患有慢性主观性耳鸣的成人 HPA 轴功能的不同影响：方法：收集了 22 名慢性主观性耳鸣患者（无重度抑郁症）和 29 名健康对照者在觉醒后、基线时和低剂量（0.5 毫克）地塞米松挑战后的唾液皮质醇数据。研究人员进行了因子方差分析，以比较组别（耳鸣患者与对照组）、创伤及其交互作用对皮质醇觉醒反应（CAR）的主要影响。以组别、取样时间、创伤及其交互作用为固定因子，以受试者为随机效应，对基线和地塞米松后皮质醇水平进行线性混合模型拟合。贝克焦虑指数、焦虑敏感性指数和恐慌症严重程度量表也被纳入该模型，以研究焦虑的影响：研究发现，组别与创伤之间存在明显的交互作用（F(1, 47) = 6.9755, p = 0.0112），仅在创伤个体中，耳鸣组的 CARs（M = 5.1808，SD = 0.5821）低于对比组（M = 5.9974; SD = 0.5251）。对基线或地塞米松后皮质醇没有影响。焦虑评分对任何结果变量都没有影响：结论：童年创伤（而非焦虑）对慢性主观性耳鸣患者的 HPA 轴功能有不同程度的影响，这在一定程度上得到了证实，因为耳鸣患者在报告早期生活逆境时发现 CAR 功能减弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.