miR-27a rs895819多态性与抑郁症患者抗抑郁治疗反应的关系

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2025-05-15 DOI:10.1159/000546405

Yanle Bai, Junjuan Zhu, Chunhu Zhang, Kuancai Deng, Yingzhi Xu

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引用次数: 0

摘要

抑郁症是一种普遍存在的心理健康障碍。miR-27a调控神经元发育。本研究旨在探讨miR-27a rs895819多态性与抑郁症患者抗抑郁治疗反应的关系。方法：采用逆转录聚合酶链反应检测miR-27a的表达水平。rs895819的基因型采用pcr -限制性片段长度多态性分析。采用17项汉密尔顿抑郁评定量表（HAMD-17）对患者进行评定。降低率= （HAMD-17基线- HAMD-17 8周）/ HAMD-17基线× 100%。有效缓解的定义为减少率≥50%。缓解定义为HAMD-17≤17。SNP与抑郁风险的相关性采用χ2检验。采用Logistic回归分析评价SNP对抗抑郁治疗反应的影响。结果：抑郁症患者173例，健康对照186例。在CC vs TT （P=0.044， OR=0.412, 95%CI=0.170 ~ 0.996）、CC+TC vs TT （OR=0.607, 95%CI=0.397 ~ 0.927）和C vs T （OR=0.633, 95%CI=0.448 ~ 0.896）模型下，rs895819与抑郁呈负相关。与TT基因型相比，TC/CC基因型个体的miR-27a表达显著降低。rs895819 （TC/CC）与有效反应呈正相关（P=0.005， OR=2.551, 95%CI=1.322 ~ 4.920）。结论：rs895819 TC/CC基因型与抑郁显著相关，且与有效应答增加相关。

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Association between miR-27a rs895819 polymorphism and antidepressant treatment response in patients with depression.

Introduction: Depression is a prevalent mental health disorder. miR-27a regulates neuronal development. This study aimed to investigate the association between the miR-27a rs895819 polymorphism and antidepressant treatment response in patients with depression.

Methods: The expression level of miR-27a was detected by reverse transcription-polymerase chain reaction. The genotype of rs895819 was performed by PCR-restriction fragment length polymorphism. The condition of patients was evaluated by a 17-item Hamilton Depression Rating Scale (HAMD-17). Reduction rate = (HAMD-17 baseline- HAMD-17 8 week)/ HAMD-17 baseline × 100%. Effective response was defined as a reduction rate of ≥50%. Remission was defined as HAMD-17 ≤17. The association between SNP and depression risk was calculated by the χ2 test. Logistic regression analysis was performed to evaluate the effects of SNP on antidepressant treatment response.

Results: There were 173 patients with depression and 186 healthy controls. rs895819 was negatively correlated with depression under CC vs. TT (P=0.044, OR=0.412, 95%CI=0.170-0.996), CC+TC vs. TT (OR=0.607, 95%CI=0.397-0.927) and C vs. T (OR=0.633, 95%CI=0.448-0.896) models. miR-27a expression was significantly decreased in individuals with TC/CC genotypes than TT genotypes. rs895819 (TC/CC) was positively correlated with the effective response (P=0.005, OR=2.551, 95%CI=1.322-4.920).

Conclusion: rs895819 TC/CC genotypes were significantly correlated with depression, and associated with increased effective response.

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.