Chemical Senses最新文献

Differences in hedonic perception of retronasal odors between young children and adults. 儿童和成人对后鼻气味享乐知觉的差异。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-10-17 DOI: 10.1093/chemse/bjaf046

Sarah E Colbert, Gaby de la Vega, Callie L Brown, Joost X Maier

{"title":"Differences in hedonic perception of retronasal odors between young children and adults.","authors":"Sarah E Colbert, Gaby de la Vega, Callie L Brown, Joost X Maier","doi":"10.1093/chemse/bjaf046","DOIUrl":"https://doi.org/10.1093/chemse/bjaf046","url":null,"abstract":"Early childhood is a critical developmental period for the establishment of flavor preferences that in turn affect food and beverage consumption and health into adulthood. Flavor is a multisensory experience, combining taste and retronasal odor signals. However, while early life development of taste perception has received ample attention, there is limited knowledge of retronasal odor perception in early life. In the present cross-sectional study, we tested the hypothesis that hedonic perception of retronasal smell differs between children and adults. We used video analysis of facial expressions to taste and retronasal odor solutions in children and adults. Children ages 3-6 and one of their parents (n=112 dyads) were asked to sample solutions containing either a taste or an odor compound. A subset of subjects (n=84 dyads) also explicitly rated each solution on a pictorial liking scale. No differences between the two age groups were observed in responses to taste solutions. In contrast, responses to retronasal odor stimuli were less stimulus-specific in children compared to adults. Children showed fewer negative facial expressions to broccoli and pumpkin odors, and more negative facial expressions to apple and mango odors. Similar differences between the two age groups were observed in explicit hedonic ratings. These findings support our hypothesis that the hedonic value of retronasal odor components of flavor are not innate but differ between young children and adults.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of purine and pyrimidine 5'-ribonucleotides on glutamate detection threshold and umami intensity in Japanese young female trained participants. 嘌呤和嘧啶5′-核糖核苷酸对日本年轻女性谷氨酸检测阈值和鲜味强度的影响。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-10-15 DOI: 10.1093/chemse/bjaf043

Kana Tanaka, Tatsuki Itoh, Takashi Kondoh

{"title":"Effects of purine and pyrimidine 5'-ribonucleotides on glutamate detection threshold and umami intensity in Japanese young female trained participants.","authors":"Kana Tanaka, Tatsuki Itoh, Takashi Kondoh","doi":"10.1093/chemse/bjaf043","DOIUrl":"https://doi.org/10.1093/chemse/bjaf043","url":null,"abstract":"Umami taste of L-glutamate can be synergistically amplified by the addition of some purine 5'-ribonucleotides, most notably inosine 5'-monophosphate (IMP) and guanosine 5'-monophosphate (GMP). However, potential synergistic effects of other 5'-ribonucleotides, such as adenosine 5'-monophosphate (AMP), cytidine 5'-monophosphate (CMP), and uridine 5'-monophosphate (UMP), have not been well characterized. Most recently, CMP has been proposed to function as a negative modulator of glutamate taste in some US participants. Here, we examined the effects of mixing these five 5'-ribonucleotides with monopotassium L-glutamate (MPG) on MPG detection threshold and umami intensity using Japanese young female trained participants. Purine 5'-ribonucleotides (IMP, GMP, AMP) significantly decreased MPG detection threshold and enhanced umami taste intensity. UMP showed a weak but significant reduction of MPG detection threshold and a slight but significant enhancement of umami intensity. CMP, however, did not modify MPG detection threshold or umami intensity. The rank order of the effects was GMP ≧ IMP > AMP > UMP. Therefore, these results did not support the hypothesis that \"CMP functions as a negative modulator of glutamate taste\", at least in the Japanese young female trained participants.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of odorant receptor transcription and gene choice. 气味受体转录和基因选择的决定因素。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-10-08 DOI: 10.1093/chemse/bjaf042

Joshua S Danoff, Kaitao Zhao, Kevin Monahan

引用次数: 0

Diverse approaches to diverse receptors: a multidimensional study of caffeine perception. 不同受体的不同途径：对咖啡因感知的多维研究。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-10-08 DOI: 10.1093/chemse/bjaf044

Stephen P Wooding

引用次数: 0

Post-oral receptors and alimentary taste: implications for energy intake and appetite. 口服后受体和食物味道：能量摄入和食欲的影响。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-09-24 DOI: 10.1093/chemse/bjaf039

Camille Pennaneach, Andrew Costanzo, Caterina Dinnella, Sara Spinelli, Erminio Monteleone, Russell Keast

{"title":"Post-oral receptors and alimentary taste: implications for energy intake and appetite.","authors":"Camille Pennaneach, Andrew Costanzo, Caterina Dinnella, Sara Spinelli, Erminio Monteleone, Russell Keast","doi":"10.1093/chemse/bjaf039","DOIUrl":"https://doi.org/10.1093/chemse/bjaf039","url":null,"abstract":"Eating behaviour is shaped by genetic, psychological, and physiological factors, with nutrient sensing playing a central role in modulating intake. The tongue, as the primary gustatory organ, initiates this process by influencing hedonic preferences, food choices, and feeding behaviour. Recent sensory research has highlighted the potential role of an emerging class of taste modalities known as alimentary tastes. This concept refers to the gustatory detection of compounds that produce weak or subtle taste perceptions but elicit strong post-oral effects. While most studies have focused on umami and fat taste in that category, growing interest surrounds newly characterised modalities such as kokumi and complex carbohydrate-associated tastes. Basic and alimentary taste stimulus influence behaviour and physiological processes both pre and post ingestion. Their receptors, present in enteroendocrine cells, detect specific nutrients and regulate gut feedback mechanisms. Emerging research is investigating not only their involvement in metabolic disorders and conditions such as malnutrition, but also their potential as therapeutic targets for modulating appetite, nutrient absorption, and endocrine responses. This narrative review aims to identify and characterise the functions of these post-oral receptors along the gastrointestinal tract in the regulation of food intake and to evaluate their therapeutic potential in metabolic conditions such as obesity and type 2 diabetes.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfaction and diabetes among older adults. 老年人的嗅觉和糖尿病。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf020

Jingjing Xia, Yaqun Yuan, Chenxi Li, Anna Kucharska-Newton, Qu Tian, Jayant M Pinto, Jiantao Ma, Eleanor M Simonsick, Honglei Chen

{"title":"Olfaction and diabetes among older adults.","authors":"Jingjing Xia, Yaqun Yuan, Chenxi Li, Anna Kucharska-Newton, Qu Tian, Jayant M Pinto, Jiantao Ma, Eleanor M Simonsick, Honglei Chen","doi":"10.1093/chemse/bjaf020","DOIUrl":"10.1093/chemse/bjaf020","url":null,"abstract":"Both poor olfaction and diabetes are common in older adults. It is biologically plausible that they may be related and interact to affect the health of older adults. We examined the association between poor olfaction and diabetes and their joint associations with mortality among 2,416 older adults from the Health, Aging, and Body Composition Study. Olfaction was assessed at year 3 (1999 to 2000) using the Brief Smell Identification Test (B-SIT). We used year 4 (2000 to 2001) as the study baseline and followed participants to year 11 (2007 to 2008) to identify incident diabetes and year 14 (2010 to 2011) to assess mortality. We used logistic regression to analyze the association of poor olfaction with prevalent diabetes and Cox proportional hazard models to assess its relationship to incident diabetes and its joint association with diabetes on mortality. Of the 2,416 participants, 611 (25.3%) had diabetes at baseline and 138 (7.6%) developed incident diabetes during 6.4 ± 1.7 yr of follow-up. Compared to those with good olfaction, the odds ratio of prevalent diabetes was 1.11 (95% confidence interval/CI: 0.87 to 1.42) for those with poor olfaction, and the corresponding hazard ratio (HR) for incident diabetes was 1.01 (95%CI: 0.66 to 1.57). During 8.2 ± 2.8 yr of follow-up, 1007 (41.7%) participants died. Compared with participants without poor olfaction and diabetes, those with both were twice likely to die during the follow-up (HR = 2.16, 95%CI: 1.71 to 2.73). However, we found no evidence for synergistic interaction (P = 0.97). In conclusion, poor olfaction is not associated with the risk of diabetes, and these two conditions independently predict mortality in older adults.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regularity, variability, and individuality: urine marking patterns of male mice toward stimuli representing varying degrees of kinship. 规律性、可变性和个体性：雄性小鼠对代表不同程度亲缘关系的刺激的尿标记模式。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf028

Eitan Yisraeli, Yifat Elizera, Yoram Ben-Shaul

{"title":"Regularity, variability, and individuality: urine marking patterns of male mice toward stimuli representing varying degrees of kinship.","authors":"Eitan Yisraeli, Yifat Elizera, Yoram Ben-Shaul","doi":"10.1093/chemse/bjaf028","DOIUrl":"https://doi.org/10.1093/chemse/bjaf028","url":null,"abstract":"Successful social interactions require the identification of conspecifics and their traits. Often, individuals do not directly interact with conspecifics, but rather with their secretions. Among bodily secretions, urine plays a primary role in social communication across species. Urine provides a wealth of social information, and accordingly, several species, including mice, use it to advertise and mark territories. Here, we asked if kinship relations are reflected by the subject's marking patterns. Specifically, we studied counter-marking patterns of outbred ICR male mice following presentation of urinary cues from conspecifics with varying degrees of kinship. Examination of more than 1000 individual marking patterns from 10 mice reveals a high degree of variability. Variability is apparent across different mice and across single marking bouts of any given individual. Yet, we identify consistent effects of stimulus kinship, and, somewhat unexpectedly, even more robust differences among individuals. Individual-specific marking patterns are also evident in an empty arena, prior to the introduction of an external stimulus. Stimulus presentation gives rise to further changes in marking patterns, reflecting the relationship between the subject and donor mice. Notably, while stimuli representing highly distinct kinship relations induce robust differences at the population level, finer distinctions, including discrimination of same-strain conspecifics and self-urine, are only displayed by a subset of mice. Thus, while counter marking patterns are determined by a variety of factors, some of which cannot be easily controlled or measured, they ultimately reflect the identity of the marker and the kinship relation with the stimulus donor.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"50 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A deep learning and digital archaeology approach for mosquito repellent discovery. 驱蚊剂发现的深度学习和数字考古方法。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf021

Jennifer N Wei, Carlos Ruiz, Marnix Vlot, Benjamin Sanchez-Lengeling, Brian K Lee, Luuk Berning, Martijn W Vos, Rob W M Henderson, Wesley W Qian, Jacob N Sanders, D Michael Ando, Kurt M Groetsch, Richard C Gerkin, Alexander B Wiltschko, Jeffrey A Riffell, Koen J Dechering

{"title":"A deep learning and digital archaeology approach for mosquito repellent discovery.","authors":"Jennifer N Wei, Carlos Ruiz, Marnix Vlot, Benjamin Sanchez-Lengeling, Brian K Lee, Luuk Berning, Martijn W Vos, Rob W M Henderson, Wesley W Qian, Jacob N Sanders, D Michael Ando, Kurt M Groetsch, Richard C Gerkin, Alexander B Wiltschko, Jeffrey A Riffell, Koen J Dechering","doi":"10.1093/chemse/bjaf021","DOIUrl":"10.1093/chemse/bjaf021","url":null,"abstract":"Insect-borne diseases kill > 0.5 million people annually. Currently available repellents for personal or household protection are limited in their efficacy, applicability, and safety profile. Here, we describe a machine-learning-driven high-throughput method for the discovery of novel repellent molecules. To achieve this, we digitized a large, historic dataset containing ~19,000 mosquito repellency measurements. We then trained a graph neural network (GNN) to map molecular structure and repellency. We applied this model to select 317 candidate molecules to test in parallelizable behavioral assays, quantifying repellency in multiple insect vectors of the pathogens of disease and in follow-up trials with human volunteers. The GNN approach outperformed a chemoinformatic model and produced a hit rate that increased with training data size, suggesting that both model innovation and novel data collection were integral to predictive accuracy. We identified > 10 molecules with repellency similar to or greater than the most widely used repellents. We analyzed the neural responses from the mosquito antennal (olfactory) lobe to selected repellents and found strong responses to many of the tested compounds, including those predicted to be strong repellents. Results from the antennal lobe recordings also demonstrated a correlation between the evoked responses to strong repellents and our GNN representation. This approach enables computational screening of billions of possible molecules to identify empirically tractable numbers of candidate repellents, leading to accelerated progress towards solving a global health challenge.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Worldwide study of the taste of bitter medicines and their modifiers. 世界范围内对苦药及其改进剂味道的研究。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf003

Ha Nguyen, Cailu Lin, Katherine Bell, Amy Huang, Mackenzie Hannum, Vicente Ramirez, Carol Christensen, Nancy E Rawson, Lauren Colquitt, Paul Domanico, Ivona Sasimovich, Riley Herriman, Paule Joseph, Oghogho Braimah, Danielle R Reed

{"title":"Worldwide study of the taste of bitter medicines and their modifiers.","authors":"Ha Nguyen, Cailu Lin, Katherine Bell, Amy Huang, Mackenzie Hannum, Vicente Ramirez, Carol Christensen, Nancy E Rawson, Lauren Colquitt, Paul Domanico, Ivona Sasimovich, Riley Herriman, Paule Joseph, Oghogho Braimah, Danielle R Reed","doi":"10.1093/chemse/bjaf003","DOIUrl":"10.1093/chemse/bjaf003","url":null,"abstract":"The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how people from diverse ancestries perceive medicines and taste modifiers, 338 adults, European and recent US and Canadian immigrants from Asia, South Asia, and Africa, rated the bitterness intensity of taste solutions on a 100-point generalized visual analog scale and provided a saliva sample for genotyping. The taste solutions were 5 medicines, tenofovir alafenamide (TAF), moxifloxacin, praziquantel, amodiaquine, and propylthiouracil (PROP), and 4 other solutions, TAF mixed with sucralose (sweet, reduces bitterness) or 6-methylflavone (tasteless, reduces bitterness), sucralose alone, and sodium chloride alone. Bitterness ratings differed by ancestry for 2 of the 5 drugs (amodiaquine and PROP) and for TAF mixed with sucralose. Genetic analysis showed that people with variants in 1 bitter receptor variant gene (TAS2R38) reported PROP was more bitter than did those with a different variant (P = 7.6e-19) and that people with either an RIMS2 or a THSD4 genotype found sucralose more bitter than did others (P = 2.6e-8, P = 7.9e-11, respectively). Our findings may help guide the formulation of bad-tasting medicines to meet the needs of those most sensitive to them.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Irregular vomeronasal system of hedgehogs is intermediate between segregated and uniform: how was type-2 receptor (V2R)-pathway in Laurasiatheria lost during evolution? 刺猬不规则的舌鼻系统介于分离和均匀之间：月牙兽的2型受体（V2R）通路是如何在进化过程中丢失的？

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf036

Daisuke Kondoh, Yusuke K Kawai, Keiko Sakai, Yusuke Tanaka, Jumpei Tomiyasu

{"title":"Irregular vomeronasal system of hedgehogs is intermediate between segregated and uniform: how was type-2 receptor (V2R)-pathway in Laurasiatheria lost during evolution?","authors":"Daisuke Kondoh, Yusuke K Kawai, Keiko Sakai, Yusuke Tanaka, Jumpei Tomiyasu","doi":"10.1093/chemse/bjaf036","DOIUrl":"10.1093/chemse/bjaf036","url":null,"abstract":"Most mammals detect important specific chemicals such as pheromones via the vomeronasal system (VNS). The types-1 (V1R) and -2 (V2R) families of vomeronasal receptors detect volatile and water-soluble substances, respectively, and couple with G protein α subunits i2 (Gαi2) and o (Gαo), respectively. The V1R/Gαi2- and V2R/Gαo-neurons in the vomeronasal organ (VNO), respectively project to the anterior and posterior halves of the accessory olfactory bulb (AOB) (i.e. segregated type) in rodents and some other mammalian species. In contrast, the VNO in most species in the Laurasiatheria clade contains only V1R/Gαi2-neurons that project to the entire AOB (i.e. uniform type). Considering the above, the posterior pathway for identifying specific emitters via the V2R families might have disappeared from the Laurasiatheria clade. Here, we analyzed the VNS of hedgehogs, one of the earliest divergent groups in the Laurasiatheria clade. In the African pigmy hedgehog (Atelerix albiventris), immunohistochemical staining using antibodies against Gαi2 and Gαo revealed that the VNO contains V1R/Gαi2- and V2R/Gαo-neurons. The vomeronasal nerve and glomerular layers of the hedgehog AOB were positive for Gαi2, and the posterior half was also positive for Gαo. This profile is intermediate between the segregated and uniform types of the mammalian VNS. Dual immunofluorescence staining also indicated that the posterior glomeruli of the hedgehog AOB comprised mixtures of V1R/Gαi2- and V2R/Gαo-axons. These features of the hedgehog VNS seem to reflect the process of evolutionary disappearance of V2R-pathway within Laurasiatheria.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0