Chemical Senses最新文献

Odors as Cognitive Constructs: History of Odor Classification and Attempts to Map Odor Percepts to Physical and Chemical Parameters. 气味作为认知结构：气味分类的历史和尝试将气味感知映射到物理和化学参数。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-07-11 DOI: 10.1093/chemse/bjaf022

Richard L Doty

{"title":"Odors as Cognitive Constructs: History of Odor Classification and Attempts to Map Odor Percepts to Physical and Chemical Parameters.","authors":"Richard L Doty","doi":"10.1093/chemse/bjaf022","DOIUrl":"https://doi.org/10.1093/chemse/bjaf022","url":null,"abstract":"Attempts to map odor percepts to physical and chemical parameters have a long and challenging history. In contrast to color vision, where three classes of photoreceptors respond to the same stimulus property (wavelength), ~400 classes of olfactory receptors are available to respond in a non-linear non-additive fashion to ~5,000 different chemical parameters. Theoretically, millions of permutations between structural elements of chemicals and their smells are possible, and some chemicals with different structures have the same odor and vice versa. Importantly, the same odor quality can come from multiple environmental objects and most odors depend upon the synthesis of a complex melody of volatile chemicals that individually can have dissimilar smells. At the individual receptor level, both agonists and antagonists within a mixture can impact receptor function. Hence, it is perhaps not surprising that no universal relationship between odor quality and underlying physical or chemical dimensions analogous to spectral wavelength for vision or air pressure waves for hearing has yet been identified. This review provides a historic account of psychological odor categorization, attempts to map odor percepts to physiochemical parameters, and attendant pitfalls. It concludes that perceived odor qualities may be best viewed as cognitive constructs with attendant variability due to individual experiences, linguistic processes, and biologic factors which do not map well to universal physiochemical dimensions.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A deep learning and digital archaeology approach for mosquito repellent discovery. 驱蚊剂发现的深度学习和数字考古方法。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-07-02 DOI: 10.1093/chemse/bjaf021

Jennifer N Wei, Carlos Ruiz, Marnix Vlot, Benjamin Sanchez-Lengeling, Brian K Lee, Luuk Berning, Martijn W Vos, Rob W M Henderson, Wesley W Qian, Jacob N Sanders, D Michael Ando, Kurt M Groetsch, Richard C Gerkin, Alexander B Wiltschko, Jeffrey A Riffell, Koen J Dechering

{"title":"A deep learning and digital archaeology approach for mosquito repellent discovery.","authors":"Jennifer N Wei, Carlos Ruiz, Marnix Vlot, Benjamin Sanchez-Lengeling, Brian K Lee, Luuk Berning, Martijn W Vos, Rob W M Henderson, Wesley W Qian, Jacob N Sanders, D Michael Ando, Kurt M Groetsch, Richard C Gerkin, Alexander B Wiltschko, Jeffrey A Riffell, Koen J Dechering","doi":"10.1093/chemse/bjaf021","DOIUrl":"https://doi.org/10.1093/chemse/bjaf021","url":null,"abstract":"Insect-borne diseases kill >0.5 million people annually. Currently available repellents for personal or household protection are limited in their efficacy, applicability, and safety profile. Here, we describe a machine-learning-driven high-throughput method for the discovery of novel repellent molecules. To achieve this, we digitized a large, historic dataset containing ~19,000 mosquito repellency measurements. We then trained a graph neural network (GNN) to map molecular structure and repellency. We applied this model to select 317 candidate molecules to test in parallelizable behavioral assays, quantifying repellency in multiple insect vectors of the pathogens of disease and in follow-up trials with human volunteers. The GNN approach outperformed a chemoinformatic model and produced a hit rate that increased with training data size, suggesting that both model innovation and novel data collection were integral to predictive accuracy. We identified >10 molecules with repellency similar to or greater than the most widely used repellents. We analyzed the neural responses from the mosquito antennal (olfactory) lobe to selected repellents and found strong responses to many of the tested compounds, including those predicted to be strong repellents. Results from the AL recordings also demonstrated a correlation between the evoked responses to strong repellents and our GNN representation. This approach enables computational screening of billions of possible molecules to identify empirically tractable numbers of candidate repellents, leading to accelerated progress towards solving a global health challenge.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The taste of trigeminal sensations: relation between taste, lingual tactile acuity, and spicy perception in patients with taste dysfunction. 三叉神经感觉的味觉：味觉功能障碍患者味觉、舌触觉敏锐度与辛辣感知的关系。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-05-28 DOI: 10.1093/chemse/bjaf016

Mariano Mastinu, Max-Vincent Schönherr, Thomas Hummel

{"title":"The taste of trigeminal sensations: relation between taste, lingual tactile acuity, and spicy perception in patients with taste dysfunction.","authors":"Mariano Mastinu, Max-Vincent Schönherr, Thomas Hummel","doi":"10.1093/chemse/bjaf016","DOIUrl":"https://doi.org/10.1093/chemse/bjaf016","url":null,"abstract":"In the oral cavity, oral stereognosis and chemesthesis refer to the abilities to recognize shapes and detect noxious substances, respectively, through various receptors distributed on the tongue. The absence of standardized methods to assess oral somatosensory perception has led to a lack of consensus regarding the relationship between taste and trigeminal sensations. While some studies reported lower trigeminal perception in taste disorders, others did not confirm this correlation. In order to analyze somatosensation in quantitative and qualitative taste problems, 28 patients (21 females, mean age 59.2 years) with taste disturbance and 32 participants (20 females, mean age 42.3 years) with normogeusia identified 3D shapes and letters, sized from 2 to 18 mm, with the anterior part of their tongue, in a threshold test. Additionally, participants rated the intensity of increasing amounts of chili. Gustatory and olfactory functions were also tested. Analyses revealed that patients with taste dysfunction had significantly higher thresholds for lingual tactile sensitivity compared to controls (p < 0.001). Moreover, patients rated the intensity of chili significantly lower than controls (p < 0.001), particularly at higher concentrations. Oral stereognosis threshold scores were negatively correlated with gustatory and olfactory functions, and decreased with increasing age, while intensity for chili correlated with taste scores (p ≤ 0.009). The findings of this study suggest that taste dysfunction is associated with low oral mechanosensory and chemesthetic functions. The testing methods used in this study could be valuable in clinical practice for assessing and monitoring sensory impairments.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of physical exercise and olfactory training with pleasant and unpleasant odors on verbal fluency and depression. 愉快气味和不愉快气味的体育锻炼和嗅觉训练对语言流畅性和抑郁的影响。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-05-03 DOI: 10.1093/chemse/bjaf013

Agnieszka Sabiniewicz, Aleksandra Reichert, Anna Oleszkiewicz, Antje Hähner, Thomas Hummel

{"title":"Effects of physical exercise and olfactory training with pleasant and unpleasant odors on verbal fluency and depression.","authors":"Agnieszka Sabiniewicz, Aleksandra Reichert, Anna Oleszkiewicz, Antje Hähner, Thomas Hummel","doi":"10.1093/chemse/bjaf013","DOIUrl":"https://doi.org/10.1093/chemse/bjaf013","url":null,"abstract":"Mechanisms of olfactory training (OT) in older adults require a more thorough investigation, considering its potential beneficial effects in age-related olfactory, cognitive, and affective decline. To address this question, we examined the role of OT odor hedonics in 128 participants aged between 50 and 85 years (Mage = 68.2 ± 7.4; 105 women and 23 men). Additionally, we explored the role of physical activity in olfactory function, depression scores, and verbal fluency. Participants were randomly assigned to one of four groups, of which two performed OT with either a) pleasant or b) unpleasant odors, or c) performed physical exercises and no OT or d) a control group without OT or physical exercises. Results indicate a beneficial effect of OT, both with pleasant and unpleasant odors, on one key domain of cognitive function, namely verbal fluency. Furthermore, physical exercise alone also caused an increase in verbal fluency. Finally, a significant beneficial effect of OT on depression score was noted, but only in the group that displayed relatively robust depression symptoms in the pre-training session. OT may be of particular use for older people due to their risk of age-related cognitive decline and depression.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfaction and diabetes among older adults. 老年人的嗅觉和糖尿病。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf020

Jingjing Xia, Yaqun Yuan, Chenxi Li, Anna Kucharska-Newton, Qu Tian, Jayant M Pinto, Jiantao Ma, Eleanor M Simonsick, Honglei Chen

{"title":"Olfaction and diabetes among older adults.","authors":"Jingjing Xia, Yaqun Yuan, Chenxi Li, Anna Kucharska-Newton, Qu Tian, Jayant M Pinto, Jiantao Ma, Eleanor M Simonsick, Honglei Chen","doi":"10.1093/chemse/bjaf020","DOIUrl":"10.1093/chemse/bjaf020","url":null,"abstract":"Both poor olfaction and diabetes are common in older adults. It is biologically plausible that they may be related and interact to affect the health of older adults. We examined the association between poor olfaction and diabetes and their joint associations with mortality among 2,416 older adults from the Health, Aging, and Body Composition Study. Olfaction was assessed at year 3 (1999 to 2000) using the Brief Smell Identification Test (B-SIT). We used year 4 (2000 to 2001) as the study baseline and followed participants to year 11 (2007 to 2008) to identify incident diabetes and year 14 (2010 to 2011) to assess mortality. We used logistic regression to analyze the association of poor olfaction with prevalent diabetes and Cox proportional hazard models to assess its relationship to incident diabetes and its joint association with diabetes on mortality. Of the 2,416 participants, 611 (25.3%) had diabetes at baseline and 138 (7.6%) developed incident diabetes during 6.4 ± 1.7 yr of follow-up. Compared to those with good olfaction, the odds ratio of prevalent diabetes was 1.11 (95% confidence interval/CI: 0.87 to 1.42) for those with poor olfaction, and the corresponding hazard ratio (HR) for incident diabetes was 1.01 (95%CI: 0.66 to 1.57). During 8.2 ± 2.8 yr of follow-up, 1007 (41.7%) participants died. Compared with participants without poor olfaction and diabetes, those with both were twice likely to die during the follow-up (HR = 2.16, 95%CI: 1.71 to 2.73). However, we found no evidence for synergistic interaction (P = 0.97). In conclusion, poor olfaction is not associated with the risk of diabetes, and these two conditions independently predict mortality in older adults.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Worldwide study of the taste of bitter medicines and their modifiers. 世界范围内对苦药及其改进剂味道的研究。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf003

Ha Nguyen, Cailu Lin, Katherine Bell, Amy Huang, Mackenzie Hannum, Vicente Ramirez, Carol Christensen, Nancy E Rawson, Lauren Colquitt, Paul Domanico, Ivona Sasimovich, Riley Herriman, Paule Joseph, Oghogho Braimah, Danielle R Reed

{"title":"Worldwide study of the taste of bitter medicines and their modifiers.","authors":"Ha Nguyen, Cailu Lin, Katherine Bell, Amy Huang, Mackenzie Hannum, Vicente Ramirez, Carol Christensen, Nancy E Rawson, Lauren Colquitt, Paul Domanico, Ivona Sasimovich, Riley Herriman, Paule Joseph, Oghogho Braimah, Danielle R Reed","doi":"10.1093/chemse/bjaf003","DOIUrl":"10.1093/chemse/bjaf003","url":null,"abstract":"The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how people from diverse ancestries perceive medicines and taste modifiers, 338 adults, European and recent US and Canadian immigrants from Asia, South Asia, and Africa, rated the bitterness intensity of taste solutions on a 100-point generalized visual analog scale and provided a saliva sample for genotyping. The taste solutions were 5 medicines, tenofovir alafenamide (TAF), moxifloxacin, praziquantel, amodiaquine, and propylthiouracil (PROP), and 4 other solutions, TAF mixed with sucralose (sweet, reduces bitterness) or 6-methylflavone (tasteless, reduces bitterness), sucralose alone, and sodium chloride alone. Bitterness ratings differed by ancestry for 2 of the 5 drugs (amodiaquine and PROP) and for TAF mixed with sucralose. Genetic analysis showed that people with variants in 1 bitter receptor variant gene (TAS2R38) reported PROP was more bitter than did those with a different variant (P = 7.6e-19) and that people with either an RIMS2 or a THSD4 genotype found sucralose more bitter than did others (P = 2.6e-8, P = 7.9e-11, respectively). Our findings may help guide the formulation of bad-tasting medicines to meet the needs of those most sensitive to them.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate liking and disgust reactions elicited by intraoral capsaicin in male mice. 雄性小鼠口服辣椒素引起的先天喜爱和厌恶反应。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf006

Yibin Han, Daisuke H Tanaka, Naofumi Uesaka

{"title":"Innate liking and disgust reactions elicited by intraoral capsaicin in male mice.","authors":"Yibin Han, Daisuke H Tanaka, Naofumi Uesaka","doi":"10.1093/chemse/bjaf006","DOIUrl":"10.1093/chemse/bjaf006","url":null,"abstract":"Liking and disgust are the primary positive and negative emotions, respectively, and are crucial for nutrient intake and toxin avoidance. These emotions are induced by multimodal stimuli, such as taste, olfactory, and somatosensory inputs, and their dysregulation is evident in various psychiatric disorders. To understand the biological basis of liking and disgust, it is crucial to establish an animal model that allows for quantitative estimation of liking and disgust in response to multimodal stimuli. The only readout shared by many species, including humans, for liking and disgust, has been taste reactivity. However, readouts of non-taste stimuli-induced emotions remain unestablished. Here, we show that intraoral administration of capsaicin, a chemosomatosensory stimulus, elicits orofacial and bodily reactions in male mice similar to those observed in taste reactivity. Capsaicin-induced liking reactions at low concentrations and disgust reactions at high concentrations. Capsaicin-induced disgust reactions consisted of various reactions, including gape and forelimb flail, with the proportion of each reaction among the disgust reactions being similar to that induced by bitter and sour stimuli. These findings indicate that orofacial and bodily reactions, defined as taste reactivity, are elicited not only by taste stimuli but also by intraoral chemosomatosensory stimuli. Understanding the biological basis of capsaicin-induced orofacial and bodily reactions will advance our understanding of the fundamental mechanisms underlying liking and disgust across sensory modalities.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features of taste disorders in Cronkhite-Canada syndrome: a report of 10 cases. cronkite - canada综合征味觉障碍的临床特征（附10例报告）

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjae044

Tomomi Nin, Koji Kamikozuru, Tetsuya Takagawa, Shinichiro Shinzaki, Kenzo Tsuzuki

{"title":"Clinical features of taste disorders in Cronkhite-Canada syndrome: a report of 10 cases.","authors":"Tomomi Nin, Koji Kamikozuru, Tetsuya Takagawa, Shinichiro Shinzaki, Kenzo Tsuzuki","doi":"10.1093/chemse/bjae044","DOIUrl":"10.1093/chemse/bjae044","url":null,"abstract":"Cronkhite-Canada syndrome (CCS) is a very rare gastrointestinal disorder with ectodermal abnormalities. Taste abnormalities appear in more than 80% of cases. Our objective was to investigate the characteristics of CCS. Ten patients with taste abnormalities who were diagnosed with CCS were included. A medical interview, examination of the tongue findings, and blood tests were performed, and taste functions were assessed using an electrogustometry (EGM) and a filter paper disc (FPD) before and after treatment. There was nail atrophy in all cases, weight loss in 8 cases, hair loss in 6 cases, skin hyperpigmentation in 5 cases, gastrointestinal symptoms in 4 cases, and atrophy of the lingual papillae in at least 8 cases. Zinc therapy for taste disorders by the previous physicians was ineffective in all cases. The results of the FPD at the first examination showed a severe decrease in taste function of the anterior tongue, whereas taste function tended to be preserved in the posterior tongue (P < 0.01, Wilcoxon). In all cases, subjective symptoms improved within 3 mo after treatment of CCS. Taste function improved significantly after treatment (FPD in anterior tongue, P < 0.05, EGM in posterior tongue, P < 0.01, Wilcoxon). Taste disorder in CCS tended to be severe in the anterior tongue with findings of tongue papillary atrophy, which appears to be an ectodermal abnormality. Their taste function improved along with symptoms after treatment. The taste tests were useful for determining the effect of treatment for CCS.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common scents? A review of potentially shared chemical signals in the order Carnivora. 共同的气味吗?食肉目潜在的共同化学信号的综述。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf019

Holly Root-Gutteridge, Neil de Kock, Madeleine Young, Andrew C Gill, Jake A Penny, Thomas W Pike, Daniel S Mills

{"title":"Common scents? A review of potentially shared chemical signals in the order Carnivora.","authors":"Holly Root-Gutteridge, Neil de Kock, Madeleine Young, Andrew C Gill, Jake A Penny, Thomas W Pike, Daniel S Mills","doi":"10.1093/chemse/bjaf019","DOIUrl":"10.1093/chemse/bjaf019","url":null,"abstract":"Many animals transmit information in the form of chemical signals to modify behavior or induce physiological change in receivers. For some taxa, such as species in the order Carnivora, chemical signals are known to provide a critical mode of communication, although they are still poorly understood compared to other signal modalities. Here, we review the literature to identify and categorize potential chemical signals within the Carnivora with a view to determining commonalities based on sex, taxon, and function. Data were drawn from 112 publications, dating from 1896 to 2021. Of the 1,532 discrete chemicals identified, 169 were detected in > 5 species, with 58 found in ≥ 10 species. However, multiple different names were often used to report the same compound, reducing the transparency of the literature. Two hundred and fifty-two chemicals were identified as biomarkers, i.e. associated with specific behavioral contexts (dominance hierarchy, appeasement, agonistic, etc.) or specific demographic traits (age, sex, etc.). Few studies established a causal link between these biomarkers and behavioral or physiological changes, so only a few could be definitively described as behaviorally functional bioactive signals. We found high variability concerning which species, chemicals, and sources were represented in the literature, which could potentially lead to a perceptual bias in the relative importance of certain chemicals. Finally, we propose a method for standardized reporting of chemical signals and suggest that future work should focus on a more consistent expansion of the range of species, products, and chemical types analyzed so that the phylogenetic relationship of chemical signals across taxa can be determined.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory responses of olfactory and vomeronasal neurons in does are influenced by buck odors and their reproductive status. 雄鹿气味及其生殖状态影响雄鹿嗅觉神经元和犁鼻神经元的感觉反应。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf012

Maxime A Meunier, Elliott Trives, Emma Gerardin, Chantal Porte, Adrien Acquistapace, Philippe Chemineau, Pablo Chamero, Hélène Vacher, Matthieu Keller

{"title":"Sensory responses of olfactory and vomeronasal neurons in does are influenced by buck odors and their reproductive status.","authors":"Maxime A Meunier, Elliott Trives, Emma Gerardin, Chantal Porte, Adrien Acquistapace, Philippe Chemineau, Pablo Chamero, Hélène Vacher, Matthieu Keller","doi":"10.1093/chemse/bjaf012","DOIUrl":"10.1093/chemse/bjaf012","url":null,"abstract":"In mammals, olfactory communication between conspecifics is crucial in modulating reproductive function. In anestrous does (i.e. female goats), exposure to hair from sexually active bucks (SAB, i.e. male goats) triggers a luteinizing hormone response that may induce ovulation, the \"male effect.\" However, the chemicals in buck hair responsible for this effect and the sensory pathways used by the females to detect this information remain insufficiently understood. In this study, we investigated whether sensory cells from the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) of does respond differently to olfactory stimuli from SAB versus wethers (CAS, i.e. castrated bucks) and how this response is influenced by the female reproductive status (breeding season, anestrous, or ovariectomized (OVX)). To explore this possibility, we stimulated freshly dissociated cells of MOE and VNO cells with chloroform/methanol and aqueous extractions from buck hair, and we assessed cell activation using calcium imaging. Regardless of the extraction method, we observed more cells activated by SAB hair compounds than by those from CAS males. More MOE cells from anestrous were activated by both chloroform and aqueous extracts from SAB than MOE cells from breeding season, or OVX does. Most of these responses originated from non-mature olfactory neurons. These findings suggest that females can discriminate buck sexual activity through sensory detection by the MOE and VNO. The increased response in the MOE to SAB hair compounds during the anestrous period suggests that the MOE may play a more significant role in the \"male effect\" during this period.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0