Chemical Senses最新文献_第2页

Human olfactory bulb morphometry and olfactory sulcus depth measurement in normosmia. 正常人嗅球形态测定和嗅沟深度测定。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2026-03-02 DOI: 10.1093/chemse/bjag008

Shubin Li, Kwangsu Kim, Akshita Joshi, Thomas Hummel

{"title":"Human olfactory bulb morphometry and olfactory sulcus depth measurement in normosmia.","authors":"Shubin Li, Kwangsu Kim, Akshita Joshi, Thomas Hummel","doi":"10.1093/chemse/bjag008","DOIUrl":"https://doi.org/10.1093/chemse/bjag008","url":null,"abstract":"This study aimed to provide a comprehensive multiobserver magnetic resonance imaging (MRI)-based assessment of olfactory bulb (OB) morphology, including volume, width, height, anterior-posterior diameter (APD), as well as olfactory sulcus (OS) depth, in normosmic adults. High-resolution MRI scans of 118 healthy participants (mean age 28.47 ± 8.20) were manually segmented by multiple observers. Interobserver reliability was generally acceptable, with OS depth and APD showing excellent agreement. Single-observer assessments were sufficient for group-level OB morphology, but caution was advised when interpreting individual cases. Besides, right OS depth and left height decreased with age in normosmic participants, and odor discrimination was positively associated with left OB width. People with deeper right OS depth had bigger right volume and longer APD. No correlations were found between olfactory function and OB morphological parameters. OS depth was consistently deeper on the right side, supporting hemispheric asymmetry. OB shape was most often oval (≈78%). Over 70% of the subjects showed left-right consistency in OB shape, but the Cohen's κ value indicated only slight (below moderate) agreement, suggesting that left-right agreement was limited. In conclusion, we presented a standardized multiobserver segmentation and measurement workflow that enabled reliable assessment of OB structure and OS depth, and offered a comprehensive characterization of OB and OS depth morphology in normosmia.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"51 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Effects of the genetic polymorphisms of TAS2R43 and TAS2R46 on receptors' function and on perceived bitterness of caffeine by human subjects. 修正：TAS2R43和TAS2R46基因多态性对受体功能和咖啡因苦味感知的影响。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2026-03-02 DOI: 10.1093/chemse/bjag005

引用次数: 0

Device color influences e-cigarette flavor expectations, perception, and appeal. 设备颜色影响电子烟口味的预期、感知和吸引力。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2026-03-02 DOI: 10.1093/chemse/bjag007

Ina M Hellmich, Reinskje Talhout, Sanne Boesveldt

{"title":"Device color influences e-cigarette flavor expectations, perception, and appeal.","authors":"Ina M Hellmich, Reinskje Talhout, Sanne Boesveldt","doi":"10.1093/chemse/bjag007","DOIUrl":"10.1093/chemse/bjag007","url":null,"abstract":"Color influences flavor expectations and experiences in foods. For example, red can enhance perceived sweetness and green can enhance sourness. Whether color similarly affects flavor perception in e-cigarettes remains unknown. As flavor strongly contributes to e-cigarette appeal, understanding the role of color may inform product regulation. We used a 3 (device color: red, green, reference) × 2 (flavor: tobacco-flavored, flavorless) × 3 (route of administration: seeing, smelling, vaping) mixed design to investigate the influence of e-cigarette color on flavor perception in 63 e-cigarette users. Brown and white devices served as reference colors. Participants rated hedonic and analytical flavor attributes on 101-unit visual analog scales. In the seeing condition, the flavor of red and green e-cigarettes was expected to be liked (ΔMax = 22) and wanted (ΔMax = 20) more than the flavor of a reference device [ΔMax indicates the largest observed difference], and expected to be more familiar (ΔMax = 23), sweet (ΔMax = 28), sour (ΔMax = 40), and fruity. These expectations were confirmed during use (smelling and vaping; where color effects were independent of e-cigarette flavor or route) compared to reference, red and green devices were rated higher in liking (ΔMax = 5), wanting (ΔMax = 6), familiarity (ΔMax = 6), sourness (ΔMax = 9), and fruitiness (ΔMax = 18). Only the red device was rated as sweeter (Δ = 7). Red and green e-cigarettes differed only in expected sourness (seeing condition, Δ = 20). We conclude that device color influences expected and experienced e-cigarette flavor perception and appeal. These findings support regulating color as part of broader flavor restriction policies.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13016966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gustatory dysfunction is associated with increased mortality Among US adults. 在美国成年人中，味觉功能障碍与死亡率增加有关。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf037

Sophie E Yu, Margaret B Mitchell, Jonathan Zou, Mitali Banerjee, Simon Chiang, Regan W Bergmark, Alice Z Maxfield, Rachel E Roditi, Sarah E Fleet, Jayant M Pinto, Kentaro Ikeda, Nicholas R Rowan, Stella E Lee

{"title":"Gustatory dysfunction is associated with increased mortality Among US adults.","authors":"Sophie E Yu, Margaret B Mitchell, Jonathan Zou, Mitali Banerjee, Simon Chiang, Regan W Bergmark, Alice Z Maxfield, Rachel E Roditi, Sarah E Fleet, Jayant M Pinto, Kentaro Ikeda, Nicholas R Rowan, Stella E Lee","doi":"10.1093/chemse/bjaf037","DOIUrl":"https://doi.org/10.1093/chemse/bjaf037","url":null,"abstract":"Gustatory dysfunction (GD), or taste dysfunction, is associated with poor quality of life. Recent literature has demonstrated an association between olfactory dysfunction (OD) and mortality in older adults. However, the association between GD and mortality has not been rigorously studied in a large national cohort. This study helps characterize this relationship and explore underlying mechanisms. Cross-sectional study of the 2013 to 2014 National Health and Nutrition Examination Survey linked to the National Death Index (NDI) through 2019. GD was assessed through self-report and psychometric recognition of quinine and salt, excluding participants with self-reported and psychometric OD. Cox proportional hazards regression models examined associations between GD and mortality, adjusting for demographics, history of cardiovascular comorbidities, diabetes, and malignancy, nutritional status, cognitive function, and depression. Subgroup analysis was also performed based on age and sex. The analytical cohort consisted of 1,136 adults aged 40 and older with complete data, subsequently weighted to create a nationally representative cohort. Isolated psychometric GD is associated with an 87% increased risk of 5-year all-cause mortality after adjusting for all covariates (HR = 1.87, 95% CI = 1.09 to 3.21, P = 0.023). This relationship remains robust among a subgroup of younger participants age 40 to 64 (HR = 18.89, 95% CI = 1.73 to 205.96, P = 0.016) and among male participants (HR = 2.53, 95% CI = 1.34 to 4.76, P = 0.004). Isolated self-reported GD is not statistically significantly associated with mortality. This is one of the first studies to demonstrate an association between GD and mortality, supporting the growing body of literature linking chemosensory dysfunction with unhealthy aging, a finding that warrants more clinical scrutiny.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"50 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A deep learning and digital archaeology approach for mosquito repellent discovery. 驱蚊剂发现的深度学习和数字考古方法。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf021

Jennifer N Wei, Carlos Ruiz, Marnix Vlot, Benjamin Sanchez-Lengeling, Brian K Lee, Luuk Berning, Martijn W Vos, Rob W M Henderson, Wesley W Qian, Jacob N Sanders, D Michael Ando, Kurt M Groetsch, Richard C Gerkin, Alexander B Wiltschko, Jeffrey A Riffell, Koen J Dechering

{"title":"A deep learning and digital archaeology approach for mosquito repellent discovery.","authors":"Jennifer N Wei, Carlos Ruiz, Marnix Vlot, Benjamin Sanchez-Lengeling, Brian K Lee, Luuk Berning, Martijn W Vos, Rob W M Henderson, Wesley W Qian, Jacob N Sanders, D Michael Ando, Kurt M Groetsch, Richard C Gerkin, Alexander B Wiltschko, Jeffrey A Riffell, Koen J Dechering","doi":"10.1093/chemse/bjaf021","DOIUrl":"10.1093/chemse/bjaf021","url":null,"abstract":"Insect-borne diseases kill > 0.5 million people annually. Currently available repellents for personal or household protection are limited in their efficacy, applicability, and safety profile. Here, we describe a machine-learning-driven high-throughput method for the discovery of novel repellent molecules. To achieve this, we digitized a large, historic dataset containing ~19,000 mosquito repellency measurements. We then trained a graph neural network (GNN) to map molecular structure and repellency. We applied this model to select 317 candidate molecules to test in parallelizable behavioral assays, quantifying repellency in multiple insect vectors of the pathogens of disease and in follow-up trials with human volunteers. The GNN approach outperformed a chemoinformatic model and produced a hit rate that increased with training data size, suggesting that both model innovation and novel data collection were integral to predictive accuracy. We identified > 10 molecules with repellency similar to or greater than the most widely used repellents. We analyzed the neural responses from the mosquito antennal (olfactory) lobe to selected repellents and found strong responses to many of the tested compounds, including those predicted to be strong repellents. Results from the antennal lobe recordings also demonstrated a correlation between the evoked responses to strong repellents and our GNN representation. This approach enables computational screening of billions of possible molecules to identify empirically tractable numbers of candidate repellents, leading to accelerated progress towards solving a global health challenge.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfaction and diabetes among older adults. 老年人的嗅觉和糖尿病。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf020

Jingjing Xia, Yaqun Yuan, Chenxi Li, Anna Kucharska-Newton, Qu Tian, Jayant M Pinto, Jiantao Ma, Eleanor M Simonsick, Honglei Chen

{"title":"Olfaction and diabetes among older adults.","authors":"Jingjing Xia, Yaqun Yuan, Chenxi Li, Anna Kucharska-Newton, Qu Tian, Jayant M Pinto, Jiantao Ma, Eleanor M Simonsick, Honglei Chen","doi":"10.1093/chemse/bjaf020","DOIUrl":"10.1093/chemse/bjaf020","url":null,"abstract":"Both poor olfaction and diabetes are common in older adults. It is biologically plausible that they may be related and interact to affect the health of older adults. We examined the association between poor olfaction and diabetes and their joint associations with mortality among 2,416 older adults from the Health, Aging, and Body Composition Study. Olfaction was assessed at year 3 (1999 to 2000) using the Brief Smell Identification Test (B-SIT). We used year 4 (2000 to 2001) as the study baseline and followed participants to year 11 (2007 to 2008) to identify incident diabetes and year 14 (2010 to 2011) to assess mortality. We used logistic regression to analyze the association of poor olfaction with prevalent diabetes and Cox proportional hazard models to assess its relationship to incident diabetes and its joint association with diabetes on mortality. Of the 2,416 participants, 611 (25.3%) had diabetes at baseline and 138 (7.6%) developed incident diabetes during 6.4 ± 1.7 yr of follow-up. Compared to those with good olfaction, the odds ratio of prevalent diabetes was 1.11 (95% confidence interval/CI: 0.87 to 1.42) for those with poor olfaction, and the corresponding hazard ratio (HR) for incident diabetes was 1.01 (95%CI: 0.66 to 1.57). During 8.2 ± 2.8 yr of follow-up, 1007 (41.7%) participants died. Compared with participants without poor olfaction and diabetes, those with both were twice likely to die during the follow-up (HR = 2.16, 95%CI: 1.71 to 2.73). However, we found no evidence for synergistic interaction (P = 0.97). In conclusion, poor olfaction is not associated with the risk of diabetes, and these two conditions independently predict mortality in older adults.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regularity, variability, and individuality: urine marking patterns of male mice toward stimuli representing varying degrees of kinship. 规律性、可变性和个体性：雄性小鼠对代表不同程度亲缘关系的刺激的尿标记模式。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf028

Eitan Yisraeli, Yifat Elizera, Yoram Ben-Shaul

{"title":"Regularity, variability, and individuality: urine marking patterns of male mice toward stimuli representing varying degrees of kinship.","authors":"Eitan Yisraeli, Yifat Elizera, Yoram Ben-Shaul","doi":"10.1093/chemse/bjaf028","DOIUrl":"https://doi.org/10.1093/chemse/bjaf028","url":null,"abstract":"Successful social interactions require the identification of conspecifics and their traits. Often, individuals do not directly interact with conspecifics, but rather with their secretions. Among bodily secretions, urine plays a primary role in social communication across species. Urine provides a wealth of social information, and accordingly, several species, including mice, use it to advertise and mark territories. Here, we asked if kinship relations are reflected by the subject's marking patterns. Specifically, we studied counter-marking patterns of outbred ICR male mice following presentation of urinary cues from conspecifics with varying degrees of kinship. Examination of more than 1000 individual marking patterns from 10 mice reveals a high degree of variability. Variability is apparent across different mice and across single marking bouts of any given individual. Yet, we identify consistent effects of stimulus kinship, and, somewhat unexpectedly, even more robust differences among individuals. Individual-specific marking patterns are also evident in an empty arena, prior to the introduction of an external stimulus. Stimulus presentation gives rise to further changes in marking patterns, reflecting the relationship between the subject and donor mice. Notably, while stimuli representing highly distinct kinship relations induce robust differences at the population level, finer distinctions, including discrimination of same-strain conspecifics and self-urine, are only displayed by a subset of mice. Thus, while counter marking patterns are determined by a variety of factors, some of which cannot be easily controlled or measured, they ultimately reflect the identity of the marker and the kinship relation with the stimulus donor.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"50 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bitter taste receptors. 苦味感受器。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf064

Maik Behrens, Silvia Schaefer

引用次数: 0

Opponent coding mechanisms in Drosophila taste neurons. 果蝇味觉神经元中的对手编码机制。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf066

Christopher Creighton, Anupama Dahanukar

引用次数: 0

Descending projections from the central nucleus of the amygdala synapse with different neuron types in the nucleus of the solitary tract. 杏仁核突触中央核与孤立束核内不同类型神经元的下降投射。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf059

Jane Bartonjo, Abigail Muccilli, Robert Lundy

{"title":"Descending projections from the central nucleus of the amygdala synapse with different neuron types in the nucleus of the solitary tract.","authors":"Jane Bartonjo, Abigail Muccilli, Robert Lundy","doi":"10.1093/chemse/bjaf059","DOIUrl":"10.1093/chemse/bjaf059","url":null,"abstract":"Several forebrain areas project to the rostral gustatory portion of the nucleus of the solitary tract (rNST), where they modulate processing of oral gustatory signals. Among them, the central nucleus of the amygdala (CeA) provides descending input via somatostatin-expressing (Sst) neurons, where suppression of CeA/Sst-to-rNST neural activity alters ingestion of the bitter tastant quinine. Together, these results indicate that the regulation of ingestive behavior involves descending neuromodulatory processes. Yet, the postsynaptic targets of CeA/Sst and non-Sst-expressing neurons in rNST, as well as the projection targets of rNST neurons receiving CeA input, remain unknown. Using a combination of transmission electron microscopy and transsynaptic viral tracing in transgenic mice, we show that CeA axon terminals in the rNST are GABAergic and form synapses with Phox2b-, glutamate-, calretinin-, and GABA-expressing neurons in distinct proportions. rNST neurons receiving CeA input were distributed across the medial, central, and ventral subdivisions and projected primarily to the ipsilateral reticular formation and parabrachial nucleus. These findings suggest that CeA input to rNST neurons influences both ascending gustatory information and orosensory motor functions, including licking, mastication, and salivation.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145573306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0