Chemical Senses最新文献_第3页

Odor-evoked food neophobia and attenuation in mice. 气味引起的小鼠新食物恐惧症和衰减。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf050

Max L Fletcher, Ian F Chapman, Keval Patel, Roshni Rameshkumar, Mariam Ceesay, Ryan Scauzillo, John D Boughter

{"title":"Odor-evoked food neophobia and attenuation in mice.","authors":"Max L Fletcher, Ian F Chapman, Keval Patel, Roshni Rameshkumar, Mariam Ceesay, Ryan Scauzillo, John D Boughter","doi":"10.1093/chemse/bjaf050","DOIUrl":"10.1093/chemse/bjaf050","url":null,"abstract":"Animals, including humans, exhibit caution when encountering novel foods, a phenomenon known as food neophobia. This hesitancy decreases with repeated exposures, provided the food is perceived as safe. While extensive research has established rodent models of food neophobia using fluid consumption tasks, studies using solid foods, particularly in mice, are relatively limited. We investigated food neophobia in mice using an olfactory-based task in which the mice were given chow odorized with isoamyl acetate. We quantified several behaviors associated with novelty response and found that the time to begin eating is the most reliable measure of neophobia. Similar levels of neophobia were found using other monomolecular odorants, suggesting that the effect is not odor specific. Further, as some reports of food neophobia in humans have suggested sex differences, we compared food neophobia behaviors in male and female mice. We observed no significant differences between the 2 groups, suggesting that the behavioral expression of food neophobia is similar across sexes. Finally, we found that food neophobia is attenuated upon a second exposure, as mice consume the odorized food as quickly as nonodorized food. Overall, our findings highlight a simple, single-test session approach for exploring olfactory-driven food neophobia.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult Drosophila aversion to caffeine requires a unique TrpA1 isoform and the PLC signaling cascade. 成年果蝇对咖啡因的厌恶需要独特的TrpA1异构体和PLC信号级联。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf058

Romane Milleville, Jade Gillas, Amanda-Thuy La, Gérard Manière, Martine Berthelot-Grosjean, Yael Grosjean, Julien Royet, Cyril Leopold Kurz

引用次数: 0

Worldwide study of the taste of bitter medicines and their modifiers. 世界范围内对苦药及其改进剂味道的研究。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf003

Ha Nguyen, Cailu Lin, Katherine Bell, Amy Huang, Mackenzie Hannum, Vicente Ramirez, Carol Christensen, Nancy E Rawson, Lauren Colquitt, Paul Domanico, Ivona Sasimovich, Riley Herriman, Paule Joseph, Oghogho Braimah, Danielle R Reed

{"title":"Worldwide study of the taste of bitter medicines and their modifiers.","authors":"Ha Nguyen, Cailu Lin, Katherine Bell, Amy Huang, Mackenzie Hannum, Vicente Ramirez, Carol Christensen, Nancy E Rawson, Lauren Colquitt, Paul Domanico, Ivona Sasimovich, Riley Herriman, Paule Joseph, Oghogho Braimah, Danielle R Reed","doi":"10.1093/chemse/bjaf003","DOIUrl":"10.1093/chemse/bjaf003","url":null,"abstract":"The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how people from diverse ancestries perceive medicines and taste modifiers, 338 adults, European and recent US and Canadian immigrants from Asia, South Asia, and Africa, rated the bitterness intensity of taste solutions on a 100-point generalized visual analog scale and provided a saliva sample for genotyping. The taste solutions were 5 medicines, tenofovir alafenamide (TAF), moxifloxacin, praziquantel, amodiaquine, and propylthiouracil (PROP), and 4 other solutions, TAF mixed with sucralose (sweet, reduces bitterness) or 6-methylflavone (tasteless, reduces bitterness), sucralose alone, and sodium chloride alone. Bitterness ratings differed by ancestry for 2 of the 5 drugs (amodiaquine and PROP) and for TAF mixed with sucralose. Genetic analysis showed that people with variants in 1 bitter receptor variant gene (TAS2R38) reported PROP was more bitter than did those with a different variant (P = 7.6e-19) and that people with either an RIMS2 or a THSD4 genotype found sucralose more bitter than did others (P = 2.6e-8, P = 7.9e-11, respectively). Our findings may help guide the formulation of bad-tasting medicines to meet the needs of those most sensitive to them.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Irregular vomeronasal system of hedgehogs is intermediate between segregated and uniform: how was type-2 receptor (V2R)-pathway in Laurasiatheria lost during evolution? 刺猬不规则的舌鼻系统介于分离和均匀之间：月牙兽的2型受体（V2R）通路是如何在进化过程中丢失的？

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf036

Daisuke Kondoh, Yusuke K Kawai, Keiko Sakai, Yusuke Tanaka, Jumpei Tomiyasu

{"title":"Irregular vomeronasal system of hedgehogs is intermediate between segregated and uniform: how was type-2 receptor (V2R)-pathway in Laurasiatheria lost during evolution?","authors":"Daisuke Kondoh, Yusuke K Kawai, Keiko Sakai, Yusuke Tanaka, Jumpei Tomiyasu","doi":"10.1093/chemse/bjaf036","DOIUrl":"10.1093/chemse/bjaf036","url":null,"abstract":"Most mammals detect important specific chemicals such as pheromones via the vomeronasal system (VNS). The types-1 (V1R) and -2 (V2R) families of vomeronasal receptors detect volatile and water-soluble substances, respectively, and couple with G protein α subunits i2 (Gαi2) and o (Gαo), respectively. The V1R/Gαi2- and V2R/Gαo-neurons in the vomeronasal organ (VNO), respectively project to the anterior and posterior halves of the accessory olfactory bulb (AOB) (i.e. segregated type) in rodents and some other mammalian species. In contrast, the VNO in most species in the Laurasiatheria clade contains only V1R/Gαi2-neurons that project to the entire AOB (i.e. uniform type). Considering the above, the posterior pathway for identifying specific emitters via the V2R families might have disappeared from the Laurasiatheria clade. Here, we analyzed the VNS of hedgehogs, one of the earliest divergent groups in the Laurasiatheria clade. In the African pigmy hedgehog (Atelerix albiventris), immunohistochemical staining using antibodies against Gαi2 and Gαo revealed that the VNO contains V1R/Gαi2- and V2R/Gαo-neurons. The vomeronasal nerve and glomerular layers of the hedgehog AOB were positive for Gαi2, and the posterior half was also positive for Gαo. This profile is intermediate between the segregated and uniform types of the mammalian VNS. Dual immunofluorescence staining also indicated that the posterior glomeruli of the hedgehog AOB comprised mixtures of V1R/Gαi2- and V2R/Gαo-axons. These features of the hedgehog VNS seem to reflect the process of evolutionary disappearance of V2R-pathway within Laurasiatheria.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate liking and disgust reactions elicited by intraoral capsaicin in male mice. 雄性小鼠口服辣椒素引起的先天喜爱和厌恶反应。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf006

Yibin Han, Daisuke H Tanaka, Naofumi Uesaka

{"title":"Innate liking and disgust reactions elicited by intraoral capsaicin in male mice.","authors":"Yibin Han, Daisuke H Tanaka, Naofumi Uesaka","doi":"10.1093/chemse/bjaf006","DOIUrl":"10.1093/chemse/bjaf006","url":null,"abstract":"Liking and disgust are the primary positive and negative emotions, respectively, and are crucial for nutrient intake and toxin avoidance. These emotions are induced by multimodal stimuli, such as taste, olfactory, and somatosensory inputs, and their dysregulation is evident in various psychiatric disorders. To understand the biological basis of liking and disgust, it is crucial to establish an animal model that allows for quantitative estimation of liking and disgust in response to multimodal stimuli. The only readout shared by many species, including humans, for liking and disgust, has been taste reactivity. However, readouts of non-taste stimuli-induced emotions remain unestablished. Here, we show that intraoral administration of capsaicin, a chemosomatosensory stimulus, elicits orofacial and bodily reactions in male mice similar to those observed in taste reactivity. Capsaicin-induced liking reactions at low concentrations and disgust reactions at high concentrations. Capsaicin-induced disgust reactions consisted of various reactions, including gape and forelimb flail, with the proportion of each reaction among the disgust reactions being similar to that induced by bitter and sour stimuli. These findings indicate that orofacial and bodily reactions, defined as taste reactivity, are elicited not only by taste stimuli but also by intraoral chemosomatosensory stimuli. Understanding the biological basis of capsaicin-induced orofacial and bodily reactions will advance our understanding of the fundamental mechanisms underlying liking and disgust across sensory modalities.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory responses of olfactory and vomeronasal neurons in does are influenced by buck odors and their reproductive status. 雄鹿气味及其生殖状态影响雄鹿嗅觉神经元和犁鼻神经元的感觉反应。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf012

Maxime A Meunier, Elliott Trives, Emma Gerardin, Chantal Porte, Adrien Acquistapace, Philippe Chemineau, Pablo Chamero, Hélène Vacher, Matthieu Keller

{"title":"Sensory responses of olfactory and vomeronasal neurons in does are influenced by buck odors and their reproductive status.","authors":"Maxime A Meunier, Elliott Trives, Emma Gerardin, Chantal Porte, Adrien Acquistapace, Philippe Chemineau, Pablo Chamero, Hélène Vacher, Matthieu Keller","doi":"10.1093/chemse/bjaf012","DOIUrl":"10.1093/chemse/bjaf012","url":null,"abstract":"In mammals, olfactory communication between conspecifics is crucial in modulating reproductive function. In anestrous does (i.e. female goats), exposure to hair from sexually active bucks (SAB, i.e. male goats) triggers a luteinizing hormone response that may induce ovulation, the \"male effect.\" However, the chemicals in buck hair responsible for this effect and the sensory pathways used by the females to detect this information remain insufficiently understood. In this study, we investigated whether sensory cells from the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) of does respond differently to olfactory stimuli from SAB versus wethers (CAS, i.e. castrated bucks) and how this response is influenced by the female reproductive status (breeding season, anestrous, or ovariectomized (OVX)). To explore this possibility, we stimulated freshly dissociated cells of MOE and VNO cells with chloroform/methanol and aqueous extractions from buck hair, and we assessed cell activation using calcium imaging. Regardless of the extraction method, we observed more cells activated by SAB hair compounds than by those from CAS males. More MOE cells from anestrous were activated by both chloroform and aqueous extracts from SAB than MOE cells from breeding season, or OVX does. Most of these responses originated from non-mature olfactory neurons. These findings suggest that females can discriminate buck sexual activity through sensory detection by the MOE and VNO. The increased response in the MOE to SAB hair compounds during the anestrous period suggests that the MOE may play a more significant role in the \"male effect\" during this period.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging decreases preferences for salts, but not for sucrose, and alters morphology of fungiform taste pores in mice. 衰老降低了对盐的偏好，但没有对蔗糖的偏好，并改变了小鼠蕈状味觉孔的形态。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf040

Kolbe M Sussman, Thomas G Mast, Joseph M Breza

{"title":"Aging decreases preferences for salts, but not for sucrose, and alters morphology of fungiform taste pores in mice.","authors":"Kolbe M Sussman, Thomas G Mast, Joseph M Breza","doi":"10.1093/chemse/bjaf040","DOIUrl":"10.1093/chemse/bjaf040","url":null,"abstract":"Mice are commonly used for laboratory research, due in large part to the widespread advancement in the genetic toolbox, such as reporters, knock-in, and knockout mice. The effects of aging on the taste system in mice have been largely unstudied. The aim of this study was to examine whether taste preferences to sucrose, NaCl, and NH4Cl were associated with aging and changes in ultrastructural characteristics of fungiform taste pores using scanning electron microscopy. Thirty-minute 2-bottle preference tests in wild-type mice indicated that preferences for NaCl and NH4Cl, but not sucrose, were significantly different in aged mice (16 to 17 months old) relative to young mice (5 months old). In the same animals, we found that the percentage of fungiform papilla with taste pores present was significantly reduced in the aged group. These findings are consistent with our recent study in rats, where aging had a significant impact on chorda tympani nerve responses to salt and ultrastructural characteristics of fungiform taste pores. Collectively, these data suggest that aging significantly affects fungiform taste pore morphology and has a significant impact on taste processing. Future studies investigating the factors that form and maintain taste pores are of critical importance as the pore is necessary for taste stimuli access to taste bud cells.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of odorant receptor transcription and gene choice. 气味受体转录和基因选择的决定因素。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf042

Joshua S Danoff, Kaitao Zhao, Kevin Monahan

引用次数: 0

Clinical features of taste disorders in Cronkhite-Canada syndrome: a report of 10 cases. cronkite - canada综合征味觉障碍的临床特征（附10例报告）

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjae044

Tomomi Nin, Koji Kamikozuru, Tetsuya Takagawa, Shinichiro Shinzaki, Kenzo Tsuzuki

{"title":"Clinical features of taste disorders in Cronkhite-Canada syndrome: a report of 10 cases.","authors":"Tomomi Nin, Koji Kamikozuru, Tetsuya Takagawa, Shinichiro Shinzaki, Kenzo Tsuzuki","doi":"10.1093/chemse/bjae044","DOIUrl":"10.1093/chemse/bjae044","url":null,"abstract":"Cronkhite-Canada syndrome (CCS) is a very rare gastrointestinal disorder with ectodermal abnormalities. Taste abnormalities appear in more than 80% of cases. Our objective was to investigate the characteristics of CCS. Ten patients with taste abnormalities who were diagnosed with CCS were included. A medical interview, examination of the tongue findings, and blood tests were performed, and taste functions were assessed using an electrogustometry (EGM) and a filter paper disc (FPD) before and after treatment. There was nail atrophy in all cases, weight loss in 8 cases, hair loss in 6 cases, skin hyperpigmentation in 5 cases, gastrointestinal symptoms in 4 cases, and atrophy of the lingual papillae in at least 8 cases. Zinc therapy for taste disorders by the previous physicians was ineffective in all cases. The results of the FPD at the first examination showed a severe decrease in taste function of the anterior tongue, whereas taste function tended to be preserved in the posterior tongue (P < 0.01, Wilcoxon). In all cases, subjective symptoms improved within 3 mo after treatment of CCS. Taste function improved significantly after treatment (FPD in anterior tongue, P < 0.05, EGM in posterior tongue, P < 0.01, Wilcoxon). Taste disorder in CCS tended to be severe in the anterior tongue with findings of tongue papillary atrophy, which appears to be an ectodermal abnormality. Their taste function improved along with symptoms after treatment. The taste tests were useful for determining the effect of treatment for CCS.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gustatory dysfunction in multiple sclerosis: a systematic review and meta-analysis. 多发性硬化症的味觉功能障碍：系统回顾和荟萃分析。

IF 1.9 4区心理学

Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjae046

Shahryar Rajai Firouzabadi, Ida Mohammadi, Mohammadreza Alinejadfard, Mohammad Yazdan Panah, Saeed Vaheb, Vahid Shaygannejad, Omid Mirmosayyeb

{"title":"Gustatory dysfunction in multiple sclerosis: a systematic review and meta-analysis.","authors":"Shahryar Rajai Firouzabadi, Ida Mohammadi, Mohammadreza Alinejadfard, Mohammad Yazdan Panah, Saeed Vaheb, Vahid Shaygannejad, Omid Mirmosayyeb","doi":"10.1093/chemse/bjae046","DOIUrl":"10.1093/chemse/bjae046","url":null,"abstract":"Gustatory dysfunction is an often overlooked symptom in people with multiple sclerosis (PwMS), potentially leading to poor appetite, malnutrition, weight loss, and decreased quality of life. This systematic review and meta-analysis aimed to assess the pooled prevalence of gustatory dysfunction in PwMS and compare their gustatory test scores with healthy controls. An online database search of PubMed, Embase, Scopus, and Web of Science was conducted on 2024 June 29. Observational studies reporting gustatory dysfunction or gustatory test scores in PwMS were included. Pooled prevalence rates were calculated using a random-effects model, with subgroup analyses based on the type of gustatory test used. Standardized mean differences (SMD) were calculated for comparisons between PwMS and healthy controls. A total of 9 studies encompassing 1385 PwMS were included. The pooled prevalence of gustatory dysfunction among PwMS was 16.4% (95% confidence intervals [95% CI]: 8.7% to 24.1%, I² = 90%, P < 0.01). Subgroup analysis showed a prevalence of 18.8% (95% CI: 10.5% to 27.2%, I² = 0%) in 4 studies using the Taste Strip Test (TST), while 3 non-TST studies using liquid tastants or self-reports reported a prevalence of 20.2% (95% CI: 7.2% to 33.3%, I² = 86%). PwMS had significantly lower gustatory test scores compared to healthy controls (SMD: -0.93, 95% CI: -1.20 to -0.65, I² = 0%, P = 0.48). Gustatory dysfunction affects a notable proportion of PwMS, with prevalence rates varying by assessment method. Future studies should assess the possible causes of gustatory dysfunction in PwMS using validated gustatory assessment scales.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0