Chemical Senses最新文献

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Soluble carrier proteins: from chemical communication to developmental biology and artificial sensing. 可溶性载体蛋白:从化学通讯到发育生物学和人工传感。
IF 1.9 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf025
Jiao Zhu, Valeriia Zaremska, Wolfgang Knoll, Paolo Pelosi
{"title":"Soluble carrier proteins: from chemical communication to developmental biology and artificial sensing.","authors":"Jiao Zhu, Valeriia Zaremska, Wolfgang Knoll, Paolo Pelosi","doi":"10.1093/chemse/bjaf025","DOIUrl":"10.1093/chemse/bjaf025","url":null,"abstract":"<p><p>The discovery of odorant-binding proteins (OBPs) at the early nineteen eighties raised a lot of interest being the first biochemical components of the olfactory system to be experimentally studied. About 10 years later, the identification of odorant receptors attracted the attention of scientists, leaving OBPs in the background. A generally accepted role as carriers for odorants and pheromones reduced the interest in these soluble proteins, regarded as accessory elements in the process of olfactory transduction. More recently, however, OBPs have received new attention based on (i) the recognition that some proteins of this family can act directly as nonvolatile pheromones, (ii) the possibility of investigating the structures of pheromones in species extinct or difficult to approach adopting the method of reverse chemical ecology, and (iii) the suitability of OBPs and their artificial mutants as sensing elements in electronic olfaction, as well as in other biotechnological applications. In this review, after summarizing the main structural and functional aspects of OBPs and other soluble carrier proteins both in mammals and in arthropods, we focus on their most recent uses and their potential developments.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semantic congruency facilitates the retrieval of visual associations to odors and decreases retroactive memory interference. 语义一致性有助于气味视觉关联的检索,减少回溯记忆干扰。
IF 1.9 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf014
Mohammad Hamzeloo, Luisa Bogenschütz, Ryan P M Hackländer, Christina Bermeitinger
{"title":"Semantic congruency facilitates the retrieval of visual associations to odors and decreases retroactive memory interference.","authors":"Mohammad Hamzeloo, Luisa Bogenschütz, Ryan P M Hackländer, Christina Bermeitinger","doi":"10.1093/chemse/bjaf014","DOIUrl":"10.1093/chemse/bjaf014","url":null,"abstract":"<p><p>Odors are often considered to be powerful memory cues, yet early olfactory paired-associate (PA) studies suggested that they are less effective than other sensory cues and particularly prone to proactive interference (PI). Research with other modalities indicates semantic similarity increases retroactive interference (RI). Two experiments compared olfactory PA memory to verbal and auditory PA memory, focusing on the role of semantic congruency. In Experiment 1, a mixed design tested the efficiency of odors as a PA cue under semantically congruent versus incongruent conditions. One hundred one participants were randomly assigned to 4 groups, each experiencing one of the following cross-modal pairs: olfactory-visual and verbal-visual (as a control group for olfactory-visual), auditory-visual, and verbal-visual (as a control group for auditory-visual). Replicating prior work, odors were less effective than verbal or auditory cues. However, semantic congruency enhanced performance across modalities, with a greater effect for olfactory PAs. Experiment 2 employed a mixed design to assess PI and RI in olfactory versus verbal PA memory. Thirty-eight participants were randomly assigned to one of two cross-modal pair groups (olfactory-visual and verbal-visual). RI was more pronounced than PI for both modalities, with RI levels increasing when the second pair of associations was semantically congruent, but the first was not. Semantic congruency consistently enhanced olfactory retrieval cues, supporting its role in mitigating interference effects. These findings demonstrate that while odors are less effective associative cues than verbal or auditory stimuli, semantic congruency significantly improves their utility, highlighting the nuanced interplay between modality and memory processes.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of the genetic polymorphisms of TAS2R43 and TAS2R46 on receptors' function and on perceived bitterness of caffeine by human subjects. TAS2R43和TAS2R46基因多态性对受体功能和咖啡因苦味感知的影响
IF 1.9 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf027
Rena Numabe, Alon Rainish, Masha Y Niv, Hiroo Imai
{"title":"Effects of the genetic polymorphisms of TAS2R43 and TAS2R46 on receptors' function and on perceived bitterness of caffeine by human subjects.","authors":"Rena Numabe, Alon Rainish, Masha Y Niv, Hiroo Imai","doi":"10.1093/chemse/bjaf027","DOIUrl":"10.1093/chemse/bjaf027","url":null,"abstract":"<p><p>We investigated the effects of coding single-nucleotide polymorphisms (SNPs) in bitter taste receptors TAS2R43 and TAS2R46 on their predicted structural stability, cellular functions, and human threshold for bitterness of caffeine. We found differences in the cell surface expression and reaction to caffeine among the haplotypes of TAS2R43 and -46 protein. Ancestral haplotypes of the proteins showed higher response to caffeine than derived haplotypes both for TAS2R43 and -46, which were also predicted to be less structurally stable and showed lower expression at the cell surface membrane. There was a significant difference in human bitter perception of caffeine between people with different TAS2R43 genotypes. Considering the functional differences based on their genotypes and the distribution of the haplotypes in the regions, these SNPs may relate to the sensitivity to several bitter compounds, which correlated with human evolution spread from Africa.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doxorubicin-induced sweet taste sensitivity reduction and compensatory receptor expression in mice. 阿霉素诱导小鼠甜味敏感性降低及代偿受体表达。
IF 1.9 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf011
Keisuke Mogi, Misaki Azuma, Shiori Iwaki, Yuka Matsuda, Katsuya Morito, Kentaro Takayama, Kazuki Nagasawa
{"title":"Doxorubicin-induced sweet taste sensitivity reduction and compensatory receptor expression in mice.","authors":"Keisuke Mogi, Misaki Azuma, Shiori Iwaki, Yuka Matsuda, Katsuya Morito, Kentaro Takayama, Kazuki Nagasawa","doi":"10.1093/chemse/bjaf011","DOIUrl":"10.1093/chemse/bjaf011","url":null,"abstract":"<p><p>In cancer chemotherapy, the development of taste disorders is a serious problem because it not only reduces quality of life but also deteriorates patients' nutritional status, sometimes resulting in cessation of chemotherapy. Doxorubicin (DOX), a widely used anticancer anthracycline, reportedly alters patients' taste perception. However, little information exists on the detailed characteristics of DOX-induced taste disorders. In this study, we investigated whether taste responsiveness was altered in DOX-administered mice using a brief-access test and examined the underlying mechanisms. DOX-administered mice exhibited decreased responsiveness to sweet taste, but not to umami, bitter, salty, or sour tastes, on day 7, with recovery by day 14. Although there was no detectable alteration in the number of type II-taste cell marker-immunoreactive cells in the circumvallate papillae (CP), expression of mRNA for sweet taste receptors T1R2, T1R3, and α-gustducin in the CP was greater in DOX-administered mice than in control mice on day 7. Interestingly, in DOX-administered mice on day 7, the lick ratios for a 300-mM sucrose solution showed a significant correlation with the relative expression of T1R3 mRNA in the CP and a trend toward a correlation with food consumption. Together, these findings suggest that the decrease in sweet taste sensitivity in DOX-administered mice might result from dysfunction in signaling downstream of taste perception, with increased sweet taste receptor expression potentially representing a compensatory response to decreased energy intake.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Olfactory training enhances semantic verbal fluency in healthy older adults, but only for individuals with low baseline performance. 嗅觉训练可提高健康老年人语义语言流畅性,但仅适用于基线表现较低的个体。
IF 1.9 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf032
Marta Rokosz, Sabina Barszcz, Michał Pieniak, Łukasz Gargula, Daniel Marek, Paulina Nawrocka, Aleksandra Reichert, Barbara Żyżelewicz, Maciej Barański, Katarzyna Resler, Anna Oleszkiewicz
{"title":"Olfactory training enhances semantic verbal fluency in healthy older adults, but only for individuals with low baseline performance.","authors":"Marta Rokosz, Sabina Barszcz, Michał Pieniak, Łukasz Gargula, Daniel Marek, Paulina Nawrocka, Aleksandra Reichert, Barbara Żyżelewicz, Maciej Barański, Katarzyna Resler, Anna Oleszkiewicz","doi":"10.1093/chemse/bjaf032","DOIUrl":"10.1093/chemse/bjaf032","url":null,"abstract":"<p><p>Olfactory training (OT), a structured exposure to odors, is commonly used by otorhinolaryngologists to treat olfactory dysfunction. However, OT has been shown to improve cognition of people with cognitive or olfactory impairments and slow the age-related cognitive decline. This study investigated whether OT could enhance cognitive functions in older adults with an intact sense of smell, compared with younger adults. We hypothesized that OT would improve semantic verbal fluency and working memory in the experimental group, with no significant changes in the placebo group (PG). The final sample comprised 184 participants aged 24 to 94 years (Mage = 51.84 ± 23.25 years), including 83 young adults (53% women, Mage = 26.71 ± 2.62 years) and 101 older adults (88% women, Mage = 72.49 ± 5.40 years). For the semantic verbal fluency task, they listed as many items as possible within one of 2 semantic categories: (i) grocery products or (ii) fragrant items, within a 60-s time limit. To measure working memory, participants completed a digit span task where they repeated sequences of digits aloud. In older adults performing OT, it led to a marginal increase in semantic verbal fluency, regardless of semantic category, while no significant changes were observed in the older PG or in young adults. This effect was mainly driven by individuals with lower scores at baseline. Our findings suggest that OT can benefit semantic verbal fluency in the healthy geriatric population with lower baseline scores, but these results urge similar testing in clinical groups with compromised verbal functions.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb. 最近的气味经验选择性地调节嗅觉敏感性通过肾小球输出在小鼠嗅球。
IF 2.8 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjae045
Narayan Subramanian, Lee Min Leong, Paria Salemi Mokri Boukani, Douglas A Storace
{"title":"Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.","authors":"Narayan Subramanian, Lee Min Leong, Paria Salemi Mokri Boukani, Douglas A Storace","doi":"10.1093/chemse/bjae045","DOIUrl":"10.1093/chemse/bjae045","url":null,"abstract":"<p><p>Although animals can reliably locate and recognize odorants embedded in complex environments, the neural circuits for accomplishing these tasks remain incompletely understood. Adaptation is likely to be important as it could allow neurons in a brain area to adjust to the broader sensory environment. Adaptive processes must be flexible enough to allow the brain to make dynamic adjustments, while maintaining sufficient stability so that organisms do not forget important olfactory associations. Processing within the mouse olfactory bulb is likely involved in generating adaptation, although there are conflicting models of how it transforms the glomerular output of the mouse olfactory bulb. Here we performed 2-photon Ca2+ imaging from mitral/tufted glomeruli in awake mice to determine the time course of recovery from adaptation, and whether it acts broadly or selectively across the glomerular population. Individual glomerular responses, as well as the overall population odor representation were similar across imaging sessions. However, odor-concentration pairings presented with interstimulus intervals upwards of 30-s evoked heterogeneous adaptation that was concentration-dependent. We demonstrate that this form of adaptation is unrelated to variations in respiration, and olfactory receptor neuron glomerular measurements indicate that it is unlikely to be inherited from the periphery. Our results indicate that the olfactory bulb output can reliably transmit stable odor representations, but recent odor experiences can selectively shape neural responsiveness for upwards of 30 seconds. We propose that neural circuits that allow for non-uniform adaptation across mitral/tufted glomeruli could be important for making dynamic adjustments in complex odor environments.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perception of citric acid and citrate salt mixtures in humans. 人体对柠檬酸和柠檬酸盐混合物的感知。
IF 2.8 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf017
Astrid E D'Andrea, Helene Hopfer, John E Hayes
{"title":"Perception of citric acid and citrate salt mixtures in humans.","authors":"Astrid E D'Andrea, Helene Hopfer, John E Hayes","doi":"10.1093/chemse/bjaf017","DOIUrl":"10.1093/chemse/bjaf017","url":null,"abstract":"<p><p>With the recent identification of a sour taste receptor Otopetrin1 in mice, interest in the perception of sourness has increased. However, research is limited with regard to the human response to organic acids in combination with organic salts. Additionally, the role of counterions in sourness perception remains underexplored. Here we report on several psychophysical experiments of citric acid and citrate mixtures. A total of 206 prescreened frequent consumers of sour foods and/or beverages (i.e. at least once a month) were recruited for this study. Participants rated attribute intensities on general Labeled Magnitude Scales for aqueous equimolar mixtures of varying citric acid and citrate ratios (monosodium citrate [n = 51 participants], disodium citrate [n = 50], trisodium citrate [n = 55], and tripotassium citrate [n = 50]), each at 3 different concentrations. Results revealed that variations in total concentration, amount of citric acid in solution, and type of citrate affected sourness perception and related attributes. Specifically, the number of counterions (i.e. 1, 2, 3 sodium ions) significantly affected sourness, puckering, and drying. The effect of the counterion type (i.e. sodium and potassium) also affected sourness and saltiness. These differences can be attributed to the chemical structures and the protonation states of the mixtures. Additionally, pH measurements revealed the same sourness levels were achieved at different pH levels. From this finding, solutions can be formulated to provide the same perceived sourness at a higher pH level.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The taste of trigeminal sensations: relation between taste, lingual tactile acuity, and spicy perception in patients with taste dysfunction. 三叉神经感觉的味觉:味觉功能障碍患者味觉、舌触觉敏锐度与辛辣感知的关系。
IF 1.9 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf016
Mariano Mastinu, Max-Vincent Schönherr, Thomas Hummel
{"title":"The taste of trigeminal sensations: relation between taste, lingual tactile acuity, and spicy perception in patients with taste dysfunction.","authors":"Mariano Mastinu, Max-Vincent Schönherr, Thomas Hummel","doi":"10.1093/chemse/bjaf016","DOIUrl":"10.1093/chemse/bjaf016","url":null,"abstract":"<p><p>In the oral cavity, oral stereognosis and chemesthesis refer to the abilities to recognize shapes and detect noxious substances, respectively, through various receptors distributed on the tongue. The absence of standardized methods to assess oral somatosensory perception has led to a lack of consensus regarding the relationship between taste and trigeminal sensations. While some studies reported lower trigeminal perception in taste disorders, others did not confirm this correlation. To analyze somatosensation in quantitative and qualitative taste problems, 28 patients (21 females, mean age 59.2 yr) with taste disturbance and 32 participants (20 females, mean age 42.3 yr) with normogeusia identified 3D shapes and letters, sized from 2 to 18 mm, with the anterior part of their tongue, in a threshold test. Additionally, participants rated the intensity of increasing amounts of chili. Gustatory and olfactory functions were also tested. Analyses revealed that patients with taste dysfunction had significantly higher thresholds for lingual tactile sensitivity compared to controls (P < 0.001). Moreover, patients rated the intensity of chili significantly lower than controls (P < 0.001), particularly at higher concentrations. Oral stereognosis threshold scores were negatively correlated with gustatory and olfactory functions, and decreased with increasing age, while intensity for chili correlated with taste scores (P ≤ 0.009). The findings of this study suggest that taste dysfunction is associated with low oral mechanosensory and chemesthetic functions. The testing methods used in this study could be valuable in clinical practice for assessing and monitoring sensory impairments.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sniffing colors-color associations for descriptors and odors of the MONEX-40 test. 嗅色。MONEX-40测试中描述符和气味的颜色关联。
IF 2.8 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf004
Sally Arnhardt, Lilian Wei Fu, Johannes Kornhuber, Jessica Freiherr
{"title":"Sniffing colors-color associations for descriptors and odors of the MONEX-40 test.","authors":"Sally Arnhardt, Lilian Wei Fu, Johannes Kornhuber, Jessica Freiherr","doi":"10.1093/chemse/bjaf004","DOIUrl":"10.1093/chemse/bjaf004","url":null,"abstract":"<p><p>Research on odor-color associations provides insights into brain processes that integrate attributes from seemingly independent senses, forming crossmodal correspondences. Since multisensory integration is based, among others, on semantic congruency, we aimed to provide a color profile-encompassing hue, saturation, and lightness-for the standardized MONEX-40 test. This color profile will enable the use of odor-congruent or odor-incongruent colors in olfactory-visual studies. In Study 1, participants completed an online survey, selecting colors corresponding to each descriptor in the smell test. The analysis revealed distinct color patterns, highlighting the importance of learning in descriptor-color associations. Study 2 explored color associations for all 40 odors of the MONEX-40 at different time points. Initially, participants reported color associations based solely on odor perception. Then, they identified the odor from a set of four descriptors and reassigned colors after odor identification. Both qualitative and quantitative methods, including statistical tests and ΔE (CIE 2000) analysis, demonstrated shifts in color associations after odor identification, affecting hue, saturation, and lightness. This research deepens our understanding of how color associations form in response to various stimuli, including descriptors and odors. The findings have scientific relevance, as mentioned above, but also practical applications in product development, particularly in the food and cosmetics industries, where combining specific colors and odors can enhance product appeal.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional characterization of Type IV basal cells in rat fungiform taste buds. 大鼠蕈状味蕾IV型基底细胞的功能表征。
IF 2.8 4区 心理学
Chemical Senses Pub Date : 2025-01-22 DOI: 10.1093/chemse/bjaf005
Albertino Bigiani, Roberto Tirindelli, MeeRa Rhyu, Jonathan Mapelli
{"title":"Functional characterization of Type IV basal cells in rat fungiform taste buds.","authors":"Albertino Bigiani, Roberto Tirindelli, MeeRa Rhyu, Jonathan Mapelli","doi":"10.1093/chemse/bjaf005","DOIUrl":"10.1093/chemse/bjaf005","url":null,"abstract":"<p><p>Taste buds, the end organs of taste, consist of a diverse population of sensory cells that is constantly renewed. Cell differentiation begins with Type IV basal cells, which are ovoid elements located inside the taste bud near its base. These cells are postmitotic precursors that give rise to all other cell types, including glial-like cells (Type I cells) and chemoreceptors (Type II and Type III cells). Despite their critical role in cell turnover, Type IV basal cells are relatively unknown in terms of functional features. Here, we used Lucifer yellow labeling and patch-clamp technique to investigate their electrophysiological properties in the rat fungiform taste buds. All Type IV basal cells showed voltage-gated sodium currents (INa), albeit at a far lower density (17 pA/pF) than chemoreceptors (444 pA/pF), which fire action potentials during sensory transduction. Furthermore, they lacked calcium homeostasis modulator currents, which are required for neurotransmitter release by some chemoreceptor types. Amiloride-sensitive epithelial sodium channel (ENaC) was found to be only present in a subset of Type IV basal cells. Interestingly, Type IV basal cells shared some membrane features with glial-like cells, such as high cell capacitance and low INa density; however, input resistance was greater in Type IV basal cells than in glial-like cells. Thus, although Type IV basal cells may eventually differentiate into distinct cell lineages, our findings indicate that they are quite homogeneous in terms of the electrophysiological characteristics, with the exception of functional ENaCs, which appear to be only expressed in one subset.</p>","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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