Chemical Senses最新文献_第5页

Sucrose, NaCl, and citric acid suppress the metallic sensation of FeSO4. 蔗糖、NaCl 和柠檬酸会抑制 FeSO4 的金属感。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjad052

Sasi Tansaraviput, Alissa A Nolden

{"title":"Sucrose, NaCl, and citric acid suppress the metallic sensation of FeSO4.","authors":"Sasi Tansaraviput, Alissa A Nolden","doi":"10.1093/chemse/bjad052","DOIUrl":"10.1093/chemse/bjad052","url":null,"abstract":"Metallic sensation is often described as unpleasant and can reduce acceptance of foods and beverages and compliance with medication. Masking and suppressing aversive sensations can help to improve acceptance of these products, with many successful strategies identified for bitterness. However, there are few studies investigating effective strategies for suppressing metallic sensation. This study aims to assess the effectiveness of mixture suppression to reduce the metallic sensation elicited from ferrous sulfate and examine whether individual differences in metallic sensation are associated with the effectiveness of suppression strategies. To achieve this, participants (n = 121) reported the intensity of suprathreshold concentrations of ferrous sulfate alone and in binary mixtures with three tastants, specifically, sucrose, citric acid, and sodium chloride. The results revealed that metallic sensation ratings were significantly lower for every binary mixture tested compared to ferrous sulfate presented in isolation. For 0.3 mM ferrous sulfate, sucrose was identified to be the most effective compound in suppressing metallic sensation, followed by citric acid and sodium chloride. For the 1.0 mM ferrous sulfate solutions, all tastants were equally effective at suppressing metallic sensation. In addition, there is a significant interaction between the perceived metallic intensity and the effectiveness of each strategy. These findings suggest that sucrose, citric acid, and sodium chloride have the potential to be effective in suppressing metallic sensation.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats. 丘脑内侧在大鼠化感偏好和消耗行为中的作用

IF 2.8 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae027

Kelly E Gartner, Chad L Samuelsen

{"title":"The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats.","authors":"Kelly E Gartner, Chad L Samuelsen","doi":"10.1093/chemse/bjae027","DOIUrl":"10.1093/chemse/bjae027","url":null,"abstract":"Experience plays a pivotal role in determining our food preferences. Consuming food generates odor-taste associations that shape our perceptual judgements of chemosensory stimuli, such as their intensity, familiarity, and pleasantness. The process of making consummatory choices relies on a network of brain regions to integrate and process chemosensory information. The mediodorsal thalamus is a higher-order thalamic nucleus involved in many experience-dependent chemosensory behaviors, including olfactory attention, odor discrimination, and the hedonic perception of flavors. Recent research has shown that neurons in the mediodorsal thalamus represent the sensory and affective properties of experienced odors, tastes, and odor-taste mixtures. However, its role in guiding consummatory choices remains unclear. To investigate the influence of the mediodorsal thalamus in the consummatory choice for experienced odors, tastes, and odor-taste mixtures, we pharmacologically inactivated the mediodorsal thalamus during 2-bottle brief-access tasks. We found that inactivation altered the preference for specific odor-taste mixtures, significantly reduced consumption of the preferred taste and increased within-trial sampling of both chemosensory stimulus options. Our results show that the mediodorsal thalamus plays a crucial role in consummatory decisions related to chemosensory preference and attention.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A non-singularity in sweet taste. 甜味的非单一性。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae006

Christian H Lemon

引用次数: 0

A status report on human odorant receptors and their allocated agonists. 人类气味受体及其分配激动剂的现状报告。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae037

Maxence Lalis, Matej Hladiš, Samar Abi Khalil, Christophe Deroo, Christophe Marin, Moustafa Bensafi, Nicolas Baldovini, Loïc Briand, Sébastien Fiorucci, Jérémie Topin

{"title":"A status report on human odorant receptors and their allocated agonists.","authors":"Maxence Lalis, Matej Hladiš, Samar Abi Khalil, Christophe Deroo, Christophe Marin, Moustafa Bensafi, Nicolas Baldovini, Loïc Briand, Sébastien Fiorucci, Jérémie Topin","doi":"10.1093/chemse/bjae037","DOIUrl":"10.1093/chemse/bjae037","url":null,"abstract":"Olfactory perception begins when odorous substances interact with specialized receptors located on the surface of dedicated sensory neurons. The recognition of smells depends on a complex mechanism involving a combination of interactions between an odorant and a set of odorant receptors (ORs), where molecules are recognized according to a combinatorial activation code of ORs. Although these interactions have been studied for decades, the rules governing this ligand recognition remain poorly understood, and the complete combinatorial code is only known for a handful of odorants. We have carefully analyzed experimental results regarding the interactions between ORs and molecules to provide a status report on the deorphanization of ORs, i.e. the identification of the first agonist for a given sequence. This meticulous analysis highlights the influence of experimental methodology (cell line or readout) on molecule-receptor association results and shows that 83% of the results are conserved regardless of experimental conditions. The distribution of another key parameter, EC50, indicates that most OR ligand activities are in the micromolar range and that impurities could lead to erroneous conclusions. Focusing on the human ORs, our study shows that 88% of the documented sequences still need to be deorphanized. Finally, we also estimate the size of the ORs' recognition range, or broadness, as the number of odorants activating a given OR. By analogously estimating molecular broadness and combining the two estimates we propose a basic framework that can serve as a comparison point for future machine learning algorithms predicting OR-molecule activity.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late olfactory bulb involvement in COVID-19. COVID19 的晚期嗅球受累。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae040

Francesco Morra, Matteo Minerva, Silvia Valeggia, Giovanni Librizzi, Elena Tramarin, Caterina Scalpelli, Anna Bordin, Giancarlo Ottaviano, Piergiorgio Gaudioso, Alessandra Bertoldo, Manuela Moretto, Alessandro Miola, Eleonora Lupia, Riccardo Ceccato, Carla Mucignat, Angelo Antonini, Renzo Manara

{"title":"Late olfactory bulb involvement in COVID-19.","authors":"Francesco Morra, Matteo Minerva, Silvia Valeggia, Giovanni Librizzi, Elena Tramarin, Caterina Scalpelli, Anna Bordin, Giancarlo Ottaviano, Piergiorgio Gaudioso, Alessandra Bertoldo, Manuela Moretto, Alessandro Miola, Eleonora Lupia, Riccardo Ceccato, Carla Mucignat, Angelo Antonini, Renzo Manara","doi":"10.1093/chemse/bjae040","DOIUrl":"10.1093/chemse/bjae040","url":null,"abstract":"Transient or persistent hypo-anosmia is common in SARS‑CoV‑2 infection but olfactory pathway late-term morphometric changes are still under investigation. We evaluated late olfactory bulb (OB) imaging changes and their correlates with the olfactory function in otherwise neurologically asymptomatic COVID-19 patients. Eighty-three subjects (mean-age 43 ± 14 yr; 54 females; time-interval infection/MRI: 129±68 d) were affected by asymptomatic to mild COVID-19 in 2020 and 25 healthy controls (mean-age 40 ± 13 yr; 9 females) underwent 3T-MRI and olfactory function evaluation through anamnestic questionnaire and Sniffin' Sticks. Exclusion criteria were intensive care treatment or neurological involvement other than olfaction. Maximal OB area was measured blindly on high-resolution coronal T2w images by 2 observers. Patients were subdivided into (i) persistently hypo/anosmic, (ii) recovered normosmic, and (iii) never complaining smell dysfunction with proven normal olfactory function. No significant differences were observed among patients' subgroups (P = 0.76). Intraobserver and interobserver reliability were high (r = 0.96 and 0.86). Former COronaVIrus Disease 19 (COVID-19) patients had decreased mean maximal OB area than controls (6.52 ± 1.11 mm2 vs. 7.26 ± 1.17 mm2, P = 0.008) even when considering persistently hypo-anosmic (6.46 ± 0.90, P = 0.006) or normosmic patients at MRI (6.57 ± 1.25, P = 0.04). SARS-CoV-2 infection is associated with mid/late-term morphological changes in the OB, regardless of presence or persistence of olfactory dysfunction. The long-term consequences on olfactory aging need to be further investigated including possible links with neurodegenerative disorders.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotional self-body odors do not influence the access to visual awareness by emotional faces. 情绪化的自我身体气味不会影响情绪化面孔进入视觉意识。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjad034

Marta Rocha, Joana Grave, Sebastian Korb, Valentina Parma, Gün R Semin, Sandra C Soares

{"title":"Emotional self-body odors do not influence the access to visual awareness by emotional faces.","authors":"Marta Rocha, Joana Grave, Sebastian Korb, Valentina Parma, Gün R Semin, Sandra C Soares","doi":"10.1093/chemse/bjad034","DOIUrl":"10.1093/chemse/bjad034","url":null,"abstract":"A growing body of research suggests that emotional chemosignals in others' body odor (BO), particularly those sampled during fearful states, enhance emotional face perception in conscious and preconscious stages. For instance, emotional faces access visual awareness faster when presented with others' fear BOs. However, the effect of these emotional signals in self-BO, that is, one's own BO, is still neglected in the literature. In the present work, we sought to determine whether emotional self-BOs modify the access to visual awareness of emotional faces. Thirty-eight women underwent a breaking-Continuous Flash Suppression task in which they were asked to detect fearful, happy, and neutral faces, as quickly and accurately as possible, while being exposed to their fear, happiness, and neutral self-BOs. Self-BOs were previously collected and later delivered via an olfactometer, using an event-related design. Results showed a main effect of emotional faces, with happy faces being detected significantly faster than fearful and neutral faces. However, our hypothesis that fear self-BOs would lead to faster emotional face detection was not confirmed, as no effect of emotional self-BOs was found-this was confirmed with Bayesian analysis. Although caution is warranted when interpreting these results, our findings suggest that emotional face perception is not modulated by emotional self-BOs, contrasting with the literature on others' BOs. Further research is needed to understand the role of self-BOs in visual processing and emotion perception.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating the patient's voice into the research agenda for treatment of chemosensory disorders. 将患者的声音纳入化感障碍治疗研究议程。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae020

Claire Murphy, Pamela Dalton, Katie Boateng, Stephanie Hunter, Pamela Silberman, Jenifer Trachtman, Suz Schrandt, Bita Naimi, Emily Garvey, Paule V Joseph, Conner Frank, Abigail Albertazzi, Gurston Nyquist, Nancy E Rawson

{"title":"Integrating the patient's voice into the research agenda for treatment of chemosensory disorders.","authors":"Claire Murphy, Pamela Dalton, Katie Boateng, Stephanie Hunter, Pamela Silberman, Jenifer Trachtman, Suz Schrandt, Bita Naimi, Emily Garvey, Paule V Joseph, Conner Frank, Abigail Albertazzi, Gurston Nyquist, Nancy E Rawson","doi":"10.1093/chemse/bjae020","DOIUrl":"10.1093/chemse/bjae020","url":null,"abstract":"World-wide some 658 million people were infected with coronavirus disease 2019 (COVID-19) and millions suffer from chemosensory impairment associated with long COVID. Current treatments for taste and smell disorders are limited. Involving patients has the potential to catalyze the dynamic exchange and development of new ideas and approaches to facilitate biomedical research and therapeutics. We assessed patients' perceptions of the efficacy of treatments for chemosensory impairment using an online questionnaire completed by 5,815 people in the US Logistic regression determined variables predictive of reported treatment efficacy for patients aged 18 to 24, 25 to 39, 40 to 60, and 60+ yrs. who were treated with nasal steroids, oral steroids, zinc, nasal rinse, smell training, theophylline, platelet-rich plasma, and Omega 3. The most consistent predictor was age, with the majority of those 40 to 60 and 60+ reporting that nasal steroids, oral steroids, zinc, nasal rinse, and smell training were only slightly effective or not effective at all. Many of these treatment strategies target regeneration and immune response, processes compromised by age. Only those under 40 reported more than slight efficacy of steroids or smell training. Findings emphasize the need to include patients of all ages in clinical trials. Older adults with olfactory impairment are at increased risk for Alzheimer's disease (AD). We speculate that olfactory impairment associated with long COVID introduces the potential for a significant rise in AD. Long COVID-associated chemosensory impairment increases the urgency for translational and clinical research on novel treatment strategies. Suggestions for high-priority areas for epidemiological, basic, and clinical research on chemosensory impairment follow.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11154145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mice learn to identify and discriminate sugar solutions based on odor cues. 小鼠学会根据气味线索识别和区分糖溶液。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae024

John I Glendinning, Alix Archambeau, Catherine Conlin, Zoee Drimmer, Gabriel Griffith, Rayna Isber, Kayla Koffler, Gabriella Ortiz, Anisha Prakash, Catherine Sollitto, Harini Srinivasan

{"title":"Mice learn to identify and discriminate sugar solutions based on odor cues.","authors":"John I Glendinning, Alix Archambeau, Catherine Conlin, Zoee Drimmer, Gabriel Griffith, Rayna Isber, Kayla Koffler, Gabriella Ortiz, Anisha Prakash, Catherine Sollitto, Harini Srinivasan","doi":"10.1093/chemse/bjae024","DOIUrl":"10.1093/chemse/bjae024","url":null,"abstract":"This study examined how olfaction impacts ingestive responses of mice to sugar solutions. Experiment 1 asked whether naïve C57BL/6 (B6) mice could identify 1 M glucose, fructose, or sucrose solutions based on odor cues, during a 30-min 2-bottle acceptability test. We tested mice both before and after they were rendered anosmic with ZnSO4 treatment. We used 2 indirect measures of odor-mediated response: number of trials initiated and latency to initiate licking. Before ZnSO4 treatment, the mice learned how to identify 1 M glucose and fructose (but not sucrose) solutions based on odor cues. ZnSO4 treatment eliminated their ability to identify the glucose and fructose solutions. Experiment 2 asked whether 2 d of exposure to a 1 M glucose, fructose, or sucrose solution improved the identification of the same sugar solution. Following exposure, the B6 mice identified all 3 sugar solutions based on odor cues. Experiment 3 asked whether T1R3 knockout mice (i.e. mice lacking the T1R3 subunit of the T1R2 + R3 sweet taste receptor) could learn to discriminate 0.44 M glucose and fructose solutions based on odor cues. All mice were subjected to a 1-h preference test, both before and after exposure to the 0.44 M glucose and fructose solutions. During exposure, the experimental mice received ZnSO4 treatment, whereas the control mice received saline treatment. Before exposure, neither type of mouse preferred the glucose solution. After exposure, the control mice preferred the glucose solution, whereas the experimental mice did not. Our results reveal that mice can learn to use odor cues to identify and discriminate between sugar solutions.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory function is reduced in a subset of former elite American football players with traumatic encephalopathy syndrome. 患有创伤性脑病综合征的前美国橄榄球精英运动员的嗅觉功能下降。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae043

Ben J Braunecker, Jenna R Groh, Charles H Adler, Michael L Alosco, David W Dodick, Yorghos Tripodis, Laura J Balcer, Charles Bernick, Sarah J Banks, William B Barr, Jennifer V Wethe, Joseph N Palmisano, Brett Martin, Kaitlin Hartlage, Robert C Cantu, Yonas E Geda, Douglas I Katz, Jesse Mez, Jeffery L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern

{"title":"Olfactory function is reduced in a subset of former elite American football players with traumatic encephalopathy syndrome.","authors":"Ben J Braunecker, Jenna R Groh, Charles H Adler, Michael L Alosco, David W Dodick, Yorghos Tripodis, Laura J Balcer, Charles Bernick, Sarah J Banks, William B Barr, Jennifer V Wethe, Joseph N Palmisano, Brett Martin, Kaitlin Hartlage, Robert C Cantu, Yonas E Geda, Douglas I Katz, Jesse Mez, Jeffery L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern","doi":"10.1093/chemse/bjae043","DOIUrl":"10.1093/chemse/bjae043","url":null,"abstract":"Former American football players are at risk for developing traumatic encephalopathy syndrome (TES), the clinical disorder associated with neuropathologically diagnosed chronic traumatic encephalopathy (CTE). The objective of this study was to determine whether hyposmia is present in traumatic encephalopathy syndrome. The study included 119 former professional American football players, 60 former college football players, and 58 same-age asymptomatic unexposed men from the DIAGNOSE CTE Research Project. All subjects included in the analysis had completed the Brief Smell Identification Test (B-SIT). Traumatic encephalopathy syndrome and the level of CTE certainty were diagnosed using the 2021 NINDS consensus diagnostic criteria. TES is categorized antemortem by provisional levels of increasing CTE certainty: Suggestive, Possible, and Probable. Former players who had traumatic encephalopathy syndrome and Probable CTE had lower B-SIT scores than those with TES and Suggestive CTE. Hyposmia was more likely in the former players with TES who were either CTE Possible or Probable than in those who did not have TES or had TES but were less likely to have CTE, or CTE Suggestive. There was no difference in B-SIT scores between all former players versus unexposed men nor overall between the football players with and without TES. We conclude that lower B-SIT scores may be a clinical biomarker for underlying CTE in former American football players.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral stimulation with glucose and fructose, but not sucrose, accelerates gastric emptying in humans. 口服葡萄糖和果糖（而非蔗糖）会加速人体胃排空。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2024-01-01 DOI: 10.1093/chemse/bjae028

Masako Kanda, Hideaki Kashima, Akira Miura, Yoshiyuki Fukuba, Makoto Takahashi, Masako Yamaoka Endo

{"title":"Oral stimulation with glucose and fructose, but not sucrose, accelerates gastric emptying in humans.","authors":"Masako Kanda, Hideaki Kashima, Akira Miura, Yoshiyuki Fukuba, Makoto Takahashi, Masako Yamaoka Endo","doi":"10.1093/chemse/bjae028","DOIUrl":"10.1093/chemse/bjae028","url":null,"abstract":"Postprandial regulation of the gastric emptying (GE) rate plays an important role in food intake. Although oral sweetening with glucose may accelerate GE, the effects of different sweetness intensities of glucose (10% and 20%, w/v) and other energy sweeteners (e.g. fructose and sucrose) remain uncertain. The purpose of this study was to determine the effects of different glucose concentrations (Experiment 1) and different sugars with the same sweet taste intensity (Experiment 2) on postprandial GE. In both experiments, after ingesting a 200 kcal carbohydrate solution containing 50 g of maltodextrin, participants repeatedly sipped, but did not swallow, one of three (water, 10% and 20%, w/v glucose) or four (water and equally sweet 20%, w/v glucose, 12%, w/v fructose, and 14%, w/v sucrose) solutions for 1 min every 5 min over a 30 min period. GE was evaluated by measuring the temporal change in the cross-sectional area of the gastric antrum using ultrasound. In Experiment 1, oral stimulation with 20% (w/v) glucose resulted in greater GE than the control stimulus (i.e. water), but the effect of stimulation with 10% (w/v) glucose on GE was not different from that of the control stimulus. In Experiment 2, stimulation with 20% (w/v) glucose or 12% (w/v) fructose resulted in greater GE than the control stimulus. However, the effect of stimulation with 14% (w/v) sucrose on GE did not differ from that of the control stimulus. Consequently, oral stimulation with glucose or fructose solutions of moderate to high sweetness following a meal facilitates postprandial GE.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0