Soluble carrier proteins: from chemical communication to developmental biology and artificial sensing.

IF 1.9 4区 心理学 Q1 BEHAVIORAL SCIENCES
Jiao Zhu, Valeriia Zaremska, Wolfgang Knoll, Paolo Pelosi
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引用次数: 0

Abstract

The discovery of odorant-binding proteins (OBPs) at the early nineteen eighties raised a lot of interest being the first biochemical components of the olfactory system to be experimentally studied. About 10 years later, the identification of odorant receptors attracted the attention of scientists, leaving OBPs in the background. A generally accepted role as carriers for odorants and pheromones reduced the interest in these soluble proteins, regarded as accessory elements in the process of olfactory transduction. More recently, however, OBPs have received new attention based on (i) the recognition that some proteins of this family can act directly as nonvolatile pheromones, (ii) the possibility of investigating the structures of pheromones in species extinct or difficult to approach adopting the method of reverse chemical ecology, and (iii) the suitability of OBPs and their artificial mutants as sensing elements in electronic olfaction, as well as in other biotechnological applications. In this review, after summarizing the main structural and functional aspects of OBPs and other soluble carrier proteins both in mammals and in arthropods, we focus on their most recent uses and their potential developments.

可溶性载体蛋白:从化学通讯到发育生物学和人工传感。
气味结合蛋白(OBPs)的发现在20世纪80年代初引起了人们的极大兴趣,因为它是嗅觉系统中第一个被实验研究的生化成分。大约十年后,气味受体的识别引起了科学家们的注意,而obp则处于次要地位。作为气味剂和信息素载体的作用被普遍接受,这降低了人们对这些可溶性蛋白质的兴趣,这些蛋白质被认为是嗅觉转导过程中的辅助元素。然而,最近OBPs受到了新的关注,基于(1)认识到该家族的一些蛋白质可以直接作为非挥发性信息素,(2)采用反向化学生态学方法研究灭绝或难以接近的物种的信息素结构的可能性,以及(3)OBPs及其人工突变体作为电子嗅觉传感元件的适用性,以及其他生物技术应用。本文综述了哺乳动物和节肢动物中OBPs和其他可溶性载体蛋白的主要结构和功能方面,重点介绍了它们的最新用途和潜在发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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