Journal of abnormal psychology最新文献

Integrated multiplexed assays of variant effect reveal cis-regulatory determinants of catechol-O-methyltransferase gene expression. 变异效应的综合多重分析揭示了儿茶酚- o -甲基转移酶基因表达的顺式调控决定因素

1区心理学

Journal of abnormal psychology Pub Date : 2023-11-17 DOI: 10.1101/2023.08.02.551517

Ian Hoskins, Shilpa Rao, Charisma Tante, Can Cenik

{"title":"Integrated multiplexed assays of variant effect reveal cis-regulatory determinants of catechol-O-methyltransferase gene expression.","authors":"Ian Hoskins, Shilpa Rao, Charisma Tante, Can Cenik","doi":"10.1101/2023.08.02.551517","DOIUrl":"10.1101/2023.08.02.551517","url":null,"abstract":"Multiplexed assays of variant effect are powerful methods to profile the consequences of rare variants on gene expression and organismal fitness. Yet, few studies have integrated several multiplexed assays to map variant effects on gene expression in coding sequences. Here, we pioneered a multiplexed assay based on polysome profiling to measure variant effects on translation at scale, uncovering single-nucleotide variants that increase and decrease ribosome load. By combining high-throughput ribosome load data with multiplexed mRNA and protein abundance readouts, we mapped the cis-regulatory landscape of thousands of catechol-O-methyltransferase (COMT) variants from RNA to protein and found numerous coding variants that alter COMT expression. Finally, we trained machine learning models to map signatures of variant effects on COMT gene expression and uncovered both directional and divergent impacts across expression layers. Our analyses reveal expression phenotypes for thousands of variants in COMT and highlight variant effects on both single and multiple layers of expression. Our findings prompt future studies that integrate several multiplexed assays for the readout of gene expression.","PeriodicalId":14793,"journal":{"name":"Journal of abnormal psychology","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79422274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The wolf. 狼。

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2023-07-18 DOI: 10.2307/j.ctt1j5dfrf.17

R. K. Greenbank

引用次数: 101

Supplemental Material for Self-Esteem and Psychosis in Daily Life: An Experience Sampling Study 日常生活中自尊与精神病的补充材料:经验抽样研究

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-12-13 DOI: 10.1037/abn0000722.supp

引用次数: 0

Supplemental Material for Longitudinal Group and Individual Networks of Eating Disorder Symptoms in Individuals Diagnosed With an Eating Disorder 在诊断为饮食失调的个体中饮食失调症状的纵向团体和个人网络补充材料

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-12-06 DOI: 10.1037/abn0000727.supp

引用次数: 0

Supplemental Material for The Impact of Punishment on Cognitive Control in a Clinical Population Characterized by Heightened Punishment Sensitivity 以惩罚敏感性高为特征的临床人群中惩罚对认知控制的影响补充材料

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-12-06 DOI: 10.1037/abn0000713.supp

引用次数: 0

Supplemental Material for Multimethod Assessment of Pubertal Timing and Associations With Internalizing Psychopathology in Early Adolescent Girls 青春期早期女孩青春期时机及其与内化心理病理学关系的多方法评估补充材料

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-12-06 DOI: 10.1037/abn0000721.supp

引用次数: 0

Supplemental Material for Analyzing Dynamic Change in Children’s Socioemotional Development Using the Strengths and Difficulties Questionnaire in a Large United Kingdom Longitudinal Study 英国大型纵向研究中使用优势和困难问卷分析儿童社会情感发展动态变化的补充材料

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-11-29 DOI: 10.1037/abn0000714.supp

引用次数: 0

Supplemental Material for Estimating the Symptom Structure of Bipolar Disorder via Network Analysis: Energy Dysregulation as a Central Symptom 通过网络分析估计双相情感障碍症状结构的补充材料:能量失调是中心症状

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-11-11 DOI: 10.1037/abn0000715.supp

引用次数: 1

Supplemental Material for All by Myself: Loneliness in Social Anxiety Disorder 《独自一人:社交焦虑障碍中的孤独》补充材料

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-11-04 DOI: 10.1037/abn0000705.supp

引用次数: 0

Network models of posttraumatic stress disorder: A meta-analysis. 创伤后应激障碍的网络模型:荟萃分析。

IF 4.6 1区心理学

Journal of abnormal psychology Pub Date : 2021-11-01 DOI: 10.1037/abn0000704

Adela-Maria Isvoranu, Sacha Epskamp, Mike W-L Cheung

{"title":"Network models of posttraumatic stress disorder: A meta-analysis.","authors":"Adela-Maria Isvoranu, Sacha Epskamp, Mike W-L Cheung","doi":"10.1037/abn0000704","DOIUrl":"https://doi.org/10.1037/abn0000704","url":null,"abstract":"Posttraumatic stress disorder (PTSD) researchers have increasingly used psychological network models to investigate PTSD symptom interactions, as well as to identify central driver symptoms. It is unclear, however, how generalizable such results are. We have developed a meta-analytic framework for aggregating network studies while taking between-study heterogeneity into account and applied this framework in the first-ever meta-analytic study of PTSD symptom networks. We analyzed the correlational structures of 52 different samples with a total sample size of n = 29,561 and estimated a single pooled network model underlying the data sets, investigated the scope of between-study heterogeneity, and assessed the performance of network models estimated from single studies. Our main findings are that: (a) We identified large between-study heterogeneity, indicating that it should be expected for networks of single studies to not perfectly align with one-another, and meta-analytic approaches are vital for the study of PTSD networks. (b) While several clear symptom-links, interpretable clusters, and significant differences between strength of edges and centrality of nodes can be identified in the network, no single or small set of nodes that clearly played a more central role than other nodes could be pinpointed, except for the symptom \"amnesia\" that was clearly the least central symptom. (c) Despite large between-study heterogeneity, we found that network models estimated from single samples can lead to similar network structures as the pooled network model. We discuss the implications of these findings for both the PTSD literature as well as methodological literature on network psychometrics. (PsycInfo Database Record (c) 2021 APA, all rights reserved).","PeriodicalId":14793,"journal":{"name":"Journal of abnormal psychology","volume":"130 8","pages":"841-861"},"PeriodicalIF":4.6,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39676558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13