Developmental psychobiology最新文献

Navigating Academic Brokering: Enhancing Belongingness in Scientific Training Programs 导航学术中介：在科学培训项目中增强归属感。

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-30 DOI: 10.1002/dev.70089

Amanda Perozo Garcia, Michelle Perez, Thania Galvan, Violeta J. Rodriguez, Dominique L. La Barrie

{"title":"Navigating Academic Brokering: Enhancing Belongingness in Scientific Training Programs","authors":"Amanda Perozo Garcia, Michelle Perez, Thania Galvan, Violeta J. Rodriguez, Dominique L. La Barrie","doi":"10.1002/dev.70089","DOIUrl":"10.1002/dev.70089","url":null,"abstract":"<div>\u0000 \u0000 <p>As more psychologists engage with marginalized communities for research, the lack of diversity in the academic workforce and inadequate cultural sensitivity training often leads to relying on trainees from underrepresented communities to bridge these gaps—a phenomenon we term “academic brokering.” Academic brokering disproportionately burdens underrepresented trainees, tasking them with facilitating their mentors’ research by serving as intermediaries between the mentor and the marginalized community to which the mentee belongs, while simultaneously navigating their academic and professional development. This practice introduces significant challenges for trainees, including balancing institutional barriers, cultural expectations, community service pressures, and advocacy efforts. This added burden can exacerbate existing stressors, leading to burnout, impeded productivity, and higher attrition rates among underrepresented trainees. Reliance on academic brokering not only places undue pressure on trainees but also risks compromising the quality and authenticity of research with marginalized communities, as it fails to address the systemic issues of cultural sensitivity and workforce diversity. This paper explores the concept of academic brokering and its impact on trainees, concluding with practical recommendations for increasing diversity in scientific training programs, integrating culturally responsive mentoring, fostering resilience among underrepresented trainees, and advocating for training program–level policies to create more equitable academic environments.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infant 6-Month Psychophysiology During Interaction With Mother Is Differentiated by 12-Month Attachment Quality 婴儿6个月与母亲互动时的心理生理特征与12个月依恋质量的差异

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-27 DOI: 10.1002/dev.70086

Bharathi J. Zvara, Roger Mills-Koonce, Cathi Propper, Karen Grewen, Brenda Pearson, Alison M. Stuebe

{"title":"Infant 6-Month Psychophysiology During Interaction With Mother Is Differentiated by 12-Month Attachment Quality","authors":"Bharathi J. Zvara, Roger Mills-Koonce, Cathi Propper, Karen Grewen, Brenda Pearson, Alison M. Stuebe","doi":"10.1002/dev.70086","DOIUrl":"https://doi.org/10.1002/dev.70086","url":null,"abstract":"<div>\u0000 \u0000 <p>Infant–mother attachment relationships play a crucial role in shaping children's psychological and physiological well-being. This study examined whether attachment quality at 12 months is associated with infant psychophysiological responses to mild stress at 6 months. Participants were 222 ethnically and socioeconomically diverse mother–infant dyads followed from the third trimester of pregnancy through the infant's first year. At 6 months, dyads participated in a free play session followed by the Face-to-Face Still-Face Paradigm (FFSFP). Infant saliva samples were collected before and after free play and at 1, 20, and 30 min post-FFSFP to measure oxytocin, cortisol, and salivary α-amylase (sAA), biomarkers associated with stress and social regulation. Maternal blood samples were collected at 10, 20, and 30 min post-FFSFP and analyzed for oxytocin and cortisol. Attachment quality was assessed at 12 months using the Ainsworth Strange Situation Paradigm. Linear mixed-effects models showed that securely attached infants had significantly higher oxytocin and lower sAA levels than insecurely attached infants, with sAA decreasing over time only in the secure group. No significant differences emerged in infant cortisol reactivity or maternal hormone levels. Findings suggest a potential link between infant attachment quality and stress regulation, particularly involving oxytocin and sympathetic nervous system activity.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Smiling and Laughter Are Linked to Enhanced Functional Brain Connectivity in Young Infants’ Default Mode Network 社交微笑和大笑与婴儿默认模式网络中增强的功能性大脑连接有关

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-25 DOI: 10.1002/dev.70088

Olivia Allison, Caroline Kelsey, Tobias Grossmann

{"title":"Social Smiling and Laughter Are Linked to Enhanced Functional Brain Connectivity in Young Infants’ Default Mode Network","authors":"Olivia Allison, Caroline Kelsey, Tobias Grossmann","doi":"10.1002/dev.70088","DOIUrl":"https://doi.org/10.1002/dev.70088","url":null,"abstract":"<p>The current study used functional near-infrared spectroscopy (fNIRS) to investigate whether and how individual differences in positive social engagement among 5-month-old (<i>N</i> = 109; <i>N</i> = 35 final sample) infants relate to variability in functional connectivity in the human brain's Default-Mode Network (DMN). Neuroimaging results showed that on average infants displayed greater functional connectivity in the right than in the left hemisphere of the DMN, adding to prior work indicating faster connectivity development in the right hemisphere. Results did not show any positive associations between our preregistered measures of positive social engagement and functional connectivity in the DMN. However, an additional analysis revealed that higher levels of infants’ smiling and laughter during daily social interactions with their caregivers positively predicted DMN functional connectivity in the left hemisphere. This suggests that individual differences in connectivity in a long-range brain network implicated in a host of social and cognitive functions are associated with some aspects of infants’ positive social-interactive behaviors.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Interpersonal Physiological Pathway Framework Linking Racism and Well-Being in Black American Families 种族主义与美国黑人家庭幸福感的人际生理通路框架

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-25 DOI: 10.1002/dev.70077

Annabelle Armah, Betty Lin

{"title":"An Interpersonal Physiological Pathway Framework Linking Racism and Well-Being in Black American Families","authors":"Annabelle Armah, Betty Lin","doi":"10.1002/dev.70077","DOIUrl":"https://doi.org/10.1002/dev.70077","url":null,"abstract":"<div>\u0000 \u0000 <p>In the US, Black parents and children are regularly exposed to multiple forms of racism, including interpersonal experiences of discrimination and structural inequities that disproportionately affect Black Americans. A sizeable body of evidence has established that these exposures can have detrimental consequences for child health and well-being, and may do so by altering individuals’ physiological functioning. However, an understanding of how racism experienced by parents and children impacts developmental parent-child processes is lacking. A comprehensive view of the mechanisms through which racism may impact child and family functioning is critical for promoting health and well-being in Black communities. This review proposes an interpersonal physiological pathway framework for conceptualizing the ways in which parent and child exposure to interpersonal and structural racism may impact physiological functioning, with implications for lifespan health and well-being. Specifically, racism is proposed to impact parent–child physiological coregulation (i.e., how dyads influence and regulate one another's physiology during interpersonal interactions), which may contribute to racial disparities in child health and well-being over time. Special consideration is given to unique parenting and sociocultural factors in Black families that may reflect coregulatory processes. Advancing research on the links between racism and coregulation could further our understanding of adaptive approaches to coregulation in Black families, with potential implications for culturally-informed family intervention and the promotion of well-being in Black youth.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental Trajectories of Delta–Beta EEG Coupling Across Infancy: The Influence of Infant Temperament and Maternal Anxiety Over Time 婴儿δ - β脑电图耦合的发展轨迹：婴儿气质和母亲焦虑随时间的影响

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-25 DOI: 10.1002/dev.70087

Berenice Anaya, Brendan Ostlund, Vanessa LoBue, Kristin A. Buss, Koraly Pérez-Edgar

{"title":"Developmental Trajectories of Delta–Beta EEG Coupling Across Infancy: The Influence of Infant Temperament and Maternal Anxiety Over Time","authors":"Berenice Anaya, Brendan Ostlund, Vanessa LoBue, Kristin A. Buss, Koraly Pérez-Edgar","doi":"10.1002/dev.70087","DOIUrl":"https://doi.org/10.1002/dev.70087","url":null,"abstract":"<div>\u0000 \u0000 <p>Coupling, or the correlation, between delta and beta EEG power may underly regulatory processes. Stronger, positive delta–beta coupling is associated with anxiety and fearful temperament, potentially tracking dysregulation. However, most studies have reported on cross-sectional investigations of delta–beta coupling in children. Thus, the normative development of delta–beta coupling remains poorly understood. Here, we leveraged a diverse sample (<i>N</i> = 165) of infants with assessments of EEG, negative affect, and maternal anxiety across 4, 8, 12, 18, and 24 months to model trajectories of delta–beta coupling and associations with infant and maternal traits over time. Multilevel models of delta (1–2.5 Hz) and beta (11–18 Hz) power indicated that delta–beta coupling increased from 8 to 24 months at the Frontal region but decreased over time at the Central and Parietal regions. Increasing negative affect over time (slope) was associated with steeper decreases in Parietal coupling. Higher maternal anxiety levels over time were associated with increasing trajectories of Parietal delta–beta coupling, but only for infants with decreasing negative affect trajectories. We show that delta–beta coupling trajectories are differentially modulated by infant temperament and anxiety levels in the infants’ proximal environment.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Dyadic Association of Testosterone With Perceived Social Support in Couples Across the Transition to Parenthood 在过渡到为人父母的夫妻中，睾酮与感知社会支持的二元关联

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-25 DOI: 10.1002/dev.70078

Nicole M. Froidevaux, Jocelyn Lai, Shauna G. Simon, Laurel Benjamin, Jennifer A. Somers, Douglas A. Granger, Dana Shai, Jessica L. Borelli

{"title":"The Dyadic Association of Testosterone With Perceived Social Support in Couples Across the Transition to Parenthood","authors":"Nicole M. Froidevaux, Jocelyn Lai, Shauna G. Simon, Laurel Benjamin, Jennifer A. Somers, Douglas A. Granger, Dana Shai, Jessica L. Borelli","doi":"10.1002/dev.70078","DOIUrl":"https://doi.org/10.1002/dev.70078","url":null,"abstract":"<p>Social support is associated with positive health outcomes and may be protective during sensitive life periods. Importantly, biological factors, including hormones, are associated with psychological and interpersonal functioning, but less is known about the link between biological factors and perceived social support during the transition to parenthood. The current study examined prenatal testosterone levels as a predictor of postpartum perceived social support among first-time parents. Participants (<i>N</i> = 110 husband–wife dyads) engaged in an ecologically valid laboratory-based infant simulator task involving an inconsolable doll. Saliva samples were collected prenatally before and after the infant simulator task. Perceived social support was self-reported prenatally and at 6 months postpartum. On average, fathers’ baseline testosterone levels were higher than mothers’ (<i>p</i> < 0.001). Most fathers and mothers demonstrated an increase in testosterone in response to the parenting task (<i>n</i><sub>fathers</sub> = 66; <i>n</i><sub>mothers</sub> = 67). An actor–partner interdependence model tested the association of prenatal baseline testosterone and testosterone reactivity predicting postpartum perceived social support, accounting for prenatal perceived social support. Findings revealed that (1) lower mother prenatal baseline testosterone was associated with higher mother postpartum perceived social support and (2) lower father prenatal testosterone reactivity was associated with higher mother postpartum perceived social support. No paths predicted fathers’ postpartum perceived social support. Interpretations and implications of these findings are discussed.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of 24-Hour Ambulatory Blood Pressure During Pregnancy in Adolescents and Young Adults With Measures of Fetal Autonomic Nervous System Development 青少年和青壮年怀孕期间24小时动态血压与胎儿自主神经系统发育的关系

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-11 DOI: 10.1002/dev.70085

Cristin M. Holland, Bradley S. Peterson, Jacquelyn Y. Taylor, Bin Cheng, Marisa N. Spann

{"title":"Association of 24-Hour Ambulatory Blood Pressure During Pregnancy in Adolescents and Young Adults With Measures of Fetal Autonomic Nervous System Development","authors":"Cristin M. Holland, Bradley S. Peterson, Jacquelyn Y. Taylor, Bin Cheng, Marisa N. Spann","doi":"10.1002/dev.70085","DOIUrl":"https://doi.org/10.1002/dev.70085","url":null,"abstract":"<div>\u0000 \u0000 <p>The autonomic nervous system regulates physiological processes, including cardiovascular functions. Changes in maternal systolic and diastolic blood pressure (SBP; DBP), as well as fetal heart rate and heart rate variability, can serve as indicators of possible risk for adverse perinatal and developmental outcomes. This study examined the association between maternal blood pressure during pregnancy and fetal autonomic nervous system heart rate indices. This was a secondary analysis of a pregnant adolescent and young adult cohort with data collected between 2009 and 2012. Ambulatory SBP and DBP measurements were recorded for 24-hours, three times across the second and third trimesters of pregnancy. Fetal heart rate indices were obtained from a standardized paradigm at 36–38 weeks gestational age. Associations of maternal ambulatory blood pressure trajectories with fetal heart rate indices were evaluated while controlling for body mass index (BMI) using linear mixed model regression. Higher maternal nighttime SBP and DBP trajectories, when controlling for pre-pregnancy BMI, were associated with greater fetal heart rate variability during rest. The associations did not survive Bonferroni correction. Nighttime blood pressure trajectories may affect the development of the fetal autonomic system, and additional research in diverse, adult samples is needed.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Neural Markers of Reward and Loss Processing and Problematic Parenting Styles A Mothers With and Without Histories of Depression 探索奖励和损失处理的神经标记以及有和没有抑郁症史的母亲的问题教养方式。

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-10 DOI: 10.1002/dev.70083

Jennifer H. Suor, Rebecca Mueller, Stewart A. Shankman, Katie L. Burkhouse

{"title":"Exploring Neural Markers of Reward and Loss Processing and Problematic Parenting Styles A Mothers With and Without Histories of Depression","authors":"Jennifer H. Suor, Rebecca Mueller, Stewart A. Shankman, Katie L. Burkhouse","doi":"10.1002/dev.70083","DOIUrl":"10.1002/dev.70083","url":null,"abstract":"<p>Depressed mothers often experience parenting difficulties, which can persist after their symptoms have remitted. However, not all depressed mothers show parenting struggles, suggesting that there could be unidentified characteristics that increase risk. Specifically, neurobiological models emphasize that reward system deficits contribute to maladaptive parenting and depression, but no studies have evaluated how they could conjointly lead to parenting challenges. This study focused on event-related potential (ERP) components, the reward positivity (RewP), and feedback negativity (FN), which assess neural responsiveness to reward and loss feedback, respectively. Mothers with (<i>n</i> = 81) and without (<i>n</i> = 55) depression histories completed a monetary reward task to elicit the FN and RewP, and depression and parenting questionnaires. We found mothers demonstrating a blunted FN to loss and increased depressive symptoms reported greater authoritarian parenting, whereas there was no association between depressive symptoms and authoritarian parenting among mothers exhibiting greater neural loss responsiveness. Furthermore, these effects were specific to maternal current depressive symptoms and not major depressive disorder (MDD) diagnostic history. Maternal depressive symptoms were associated with reduced warmth, but the RewP did not moderate this association. Together, findings suggest that depressed mothers with blunted responsiveness to negative cues may be particularly vulnerable to adopt authoritarian parenting styles.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Buffering of Acute Early Life Stress Sex-Dependently Ameliorates Fear Incubation in Adulthood 社会缓冲急性早期生活压力的性别依赖性改善成年期的恐惧孵化

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-09 DOI: 10.1002/dev.70082

Amanda N. Reichert, Collin A. Riddle, Jennifer J. Quinn

{"title":"Social Buffering of Acute Early Life Stress Sex-Dependently Ameliorates Fear Incubation in Adulthood","authors":"Amanda N. Reichert, Collin A. Riddle, Jennifer J. Quinn","doi":"10.1002/dev.70082","DOIUrl":"https://doi.org/10.1002/dev.70082","url":null,"abstract":"<p>Social buffering may reduce the persistent impacts of acute early life stress (aELS) and, thus, has important implications for anxiety- and trauma-related disorders. First, we assessed whether aELS would induce maladaptive fear incubation in adult mice, a PTSD-like phenotype. Overall, animals showed incubation of fear memory in adulthood, independent of aELS condition. Next, we investigated whether social interaction with the dam and/or the littermates following the aELS session would eliminate adult fear incubation. Males demonstrated social buffering only if the dam was present, and females demonstrated social buffering only if the littermates were present. Finally, we assessed whether social buffering following aELS exposure reduces consolidation of the associative fear learning that occurs during the aELS session. Animals received aELS followed by isolation or social interaction (dam + littermates). Over the next four consecutive days, they received 30-min exposures to the context (test/extinction). There were no differences between isolation and social interaction on contextual fear memory expression or its extinction. Taken together, these results indicate that social buffering reduces the impact of nonassociative processes during aELS on subsequent adult fear memory in a sex-dependent manner and further supports social buffering as an important intervention following early trauma experiences.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrous Cycle Impacts Fear Extinction and Relapse in Female Adolescent Rats 发情周期影响青春期雌性大鼠恐惧消退和复发

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2025-09-09 DOI: 10.1002/dev.70084

August Gable, Rick Richardson, Kathryn D. Baker

{"title":"Estrous Cycle Impacts Fear Extinction and Relapse in Female Adolescent Rats","authors":"August Gable, Rick Richardson, Kathryn D. Baker","doi":"10.1002/dev.70084","DOIUrl":"https://doi.org/10.1002/dev.70084","url":null,"abstract":"<p>Adolescent male rodents and humans exhibit impairments in extinguishing learned fear. Here, we investigated whether female adolescent rats exhibit such impairments and if extinction is affected by the estrous cycle as in adults. Following fear conditioning to a discrete cue, female adolescent Sprague Dawley rats were extinguished either around the onset of puberty, when estrous cycling begins, or across different stages of the estrous cycle. Both extinction retention and renewal (a form of relapse) were assessed. Peri-pubertal females had comparable freezing during extinction training and tests of extinction retention and fear renewal as age-matched males. They were noted to generally be in metestrus, a low estradiol phase, at extinction training. Postpubertal females that received extinction training in proestrus (high estradiol phase), but not metestrus (low estradiol phase), had lower freezing during extinction training and retention than males; males exhibited more freezing during a renewal test than both groups of females. Our findings suggest that female adolescent rats have reduced fear during extinction training and retention compared to males only when extinguished in a high-estradiol phase. These findings suggest fear inhibition fluctuates across the estrous cycle in adolescence, and estradiol may protect females against impairments in fear extinction during this developmental period.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0