Developmental psychobiology最新文献

{"title":"Adrenal Biomarkers of Stress in Transgender and Gender-Diverse Adolescents.","authors":"Simone Coslovich, Stefania Tonetto, Giulia Bragato, Gianluca Tamaro, Alice Fachin, Paolo Dalena, Lorenzo Zandonà, Antonella Fabretto, Egidio Barbi, Gianluca Tornese","doi":"10.1002/dev.70156","DOIUrl":"10.1002/dev.70156","url":null,"abstract":"<p><p>Transgender and gender diverse (TGD) adolescents are frequently exposed to minority stress, which may influence the hypothalamic-pituitary-adrenal (HPA) axis during critical developmental windows. Altered cortisol dynamics have been described in populations facing chronic stress, yet evidence in TGD youth is limited. Understanding adrenal function in this context is essential for clarifying potential biological pathways linking social stressors to developmental and health outcomes. In the present study, identifying as TGD serves as an indirect proxy of exposure to minority stressors, which were not directly measured. We conducted a retrospective, case-control study at a tertiary pediatric center, including 48 TGD adolescents and 298 controls referred for evaluation of premature pubarche with nonclassical congenital adrenal hyperplasia excluded. All participants underwent a standard dose synacthen test (SDST; 250 µg tetracosactide iv, sampling at baseline and 60 min, 8:00 a.m.), which assesses adrenal responsiveness to pharmacological ACTH stimulation. Serum cortisol, DHEAS, ACTH, and 17-hydroxyprogesterone were assayed. Statistical analyses included nonparametric group comparisons, correlations, and multivariable regression adjusting for age and sex assigned at birth. TGD individuals demonstrated significantly higher baseline cortisol levels (293 vs. 214 nmol/L; p < 0.001) and a reduced cortisol response to SDST (Δcortisol: 354 vs. 446 nmol/L; p < 0.001). In the full sample, basal DHEAS levels were higher in TGD youth (231 vs. 142 nmol/L; p = 0.362), whereas the DHEAS-to-cortisol ratio did not differ significantly between groups. In an age-matched subsample (1:2 matching), the DHEAS-to-cortisol ratio was significantly lower in TGD adolescents (0.72 vs. 1.03; p = 0.004). Multivariate analysis confirmed an independent association between TGD status and higher basal cortisol, lower Δcortisol, and a reduced DHEAS-to-cortisol ratio after adjustment for covariates (all p < 0.001). Our findings provide preliminary evidence of altered adrenal responsiveness in TGD adolescents, potentially reflecting the biological embedding of minority stress during development. Although exploratory, these results highlight the need for prospective, longitudinal studies integrating psychosocial and neuroendocrine measures to clarify mechanisms linking stress, HPA axis function, and developmental outcomes in gender-diverse youth.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":"e70156"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preconception Exposure to Chronic Stressors Impairs Social Behaviors in Prairie Vole Offspring (Microtus ochrogaster): Partial Mediation by Parental Pair-Bonding and Parenting Behaviors.","authors":"W Tang Watanasriyakul","doi":"10.1002/dev.70158","DOIUrl":"https://doi.org/10.1002/dev.70158","url":null,"abstract":"<p><p>Chronic stress can induce lasting physiological changes that may affect subsequent generations. Parental factors-such as affect, interparental relationship quality, and parenting styles-are potential mediators of these intergenerational effects. Utilizing the socially monogamous and biparental prairie vole, we previously reported that parents with a history of chronic stress exposure prior to conception (vs. stress-naïve parents), exhibited poorer pair-bonding quality and preferred maintaining physical contact while parenting. However, the impact of these subtle parental differences on offspring development remained unclear. Therefore, the current study examined the developmental and sociobehavioral outcomes in offspring indirectly exposed to preconception stress or in stress-naïve offspring. Indirectly stress-exposed offspring showed reduced allogrooming in juvenile males, inhibited social play in both sexes, and decreased self-grooming in adult females relative to their stress-naïve counterparts. These behavioral changes were partially mediated by parental allogrooming and aggression during early pair-bonding and parental proximity during the parental care task. These findings indicate that preconception stress is associated with impaired offspring sociobehavioral development, primarily through modifications in interparental relationships and parenting styles. These results underscore the importance of the preconception period in shaping offspring development and may inform both preclinical studies of stress transmission and clinical interventions targeting family dynamics.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":"e70158"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Neonatal Imitation and General Movements Assessment in Late Preterm Infants.","authors":"Mürüvvet Elif Şimşir, Defne Engur, Canberk Yılmaz, Irem Zengi, Pinar Gencpinar, Anil Soykan, Nihal Olgac Dündar","doi":"10.1002/dev.70159","DOIUrl":"https://doi.org/10.1002/dev.70159","url":null,"abstract":"<p><p>Neonatal imitation (NI) is a foundational marker of early social-cognitive development, yet its universality remains debated, particularly in non-WEIRD (Western, Educated, Industrialized, Rich, and Democratic) populations and in infants at higher neurodevelopmental risk. This study examined NI in healthy late-preterm newborns, compared their responses with term infants, and explored the prognostic value of imitation using longitudinal Prechtl's General Movements Assessment (GMA). Twenty-three late-preterm and 27 term infants were tested within 72 h of birth for facial imitation using a blinded, counterbalanced protocol focusing on mouth opening (MO) and tongue protrusion (TP). Neurodevelopmental status was assessed using Prechtl's GMA at corrected ages of 5 and 11 weeks. Both groups exhibited significantly more TP gestures in response to the matching TP model (late-preterm: p = 0.002; term: p < 0.001), whereas MO responses did not differ significantly (p > 0.05). Imitative behavior was present from Day 1 (p = 0.005) and strengthened on Days 2-3 (p < 0.001). No significant sex differences were observed. NI scores did not significantly correlate with GMA outcomes (p > 0.05), likely reflecting the clinical homogeneity of this mostly healthy sample. Selective NI for TP emerges within the first days of life in both late preterm and term infants. By including a non-WEIRD population and late preterm infants, this study expands the generalizability of NI. Strengths include early assessment, blinded scoring, and standardized neurodevelopmental evaluation. NI appears robust across gestational age and sociocultural contexts, highlighting its potential as an early neurobehavioral marker. Further longitudinal research in diverse populations is warranted.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":"e70159"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair Cortisol Concentrations in Children: A Longitudinal Analysis Across Childhood.","authors":"Miguel Ángel Baos-González, Javier De Echarri-Lorente, María Ángeles García-León, Raquel González-Pérez, María Isabel Peralta-Ramírez","doi":"10.1002/dev.70154","DOIUrl":"10.1002/dev.70154","url":null,"abstract":"<p><p>Hair cortisol concentration (HCC) reflects long-term cortisol exposure and is commonly used as a biomarker of hypothalamic-pituitary-adrenal axis activity. Although increasingly applied in pediatric populations, developmental changes in HCC and potential sex differences remain unclear. This longitudinal study examined HCC across childhood and the influence of sociodemographic and perinatal factors. A total of 212 mother-child dyads participated. Sociodemographic and perinatal data were collected during pregnancy and postpartum. Offspring HCC (pg/mg) was assessed at birth, 6 months, and annually from 1 to 7 years. HCC decreased with age, with the steepest decline occurring in early childhood and greater stability observed between 4 and 7 years of age. Sex differences emerged only at 3 years, with higher HCC in females. Standardized birth height was negatively associated with newborn HCC; maternal BMI and weight before and during pregnancy were negatively associated with HCC at 1-2 years; and gestational week at delivery was positively associated with HCC at 3 years. Descriptive HCC percentiles were calculated for newborns, at 6 months, and at ages 1-3 years. These findings illustrate the developmental trajectory of HCC across childhood and provide insights into sociodemographic and perinatal factors associated with children's HCC.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":"e70154"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone Levels, Challenging Parenting Behavior, and Protective Parenting Behavior: A Correlational Study Among First-Time Fathers in the First Year of Fatherhood.","authors":"Annemieke M Witte, Carolina Santos, Mirjana Majdandžić, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg","doi":"10.1002/dev.70160","DOIUrl":"https://doi.org/10.1002/dev.70160","url":null,"abstract":"<p><p>Only few studies have examined whether testosterone levels are involved in parenting behaviors other than sensitivity and nurturing behavior. This preregistered study examined associations between fathers' hair testosterone levels, challenging parenting behavior (CPB), and protective parenting. Seventy first-time partnered fathers with a healthy-born infant (M = 6.70 months, SD = 2.16) visited our research center for hormonal and behavioral assessments. Hair samples were collected to measure testosterone concentrations over the past month. CPB was observed during father-infant free play interaction and coded for the extent to which fathers verbally and physically challenged their infants to act outside their comfort zone. Paternal sensitivity was independently rated and analyzed exploratively. Protective parenting behavior was observed during the auditory startling task, which involved exposing the dyads to a short, unexpected loud sound. No significant correlations between fathers' hair testosterone levels, CPB, and protective parenting emerged. Exploratory analyses (not preregistered) showed that fathers with lower testosterone levels were more sensitive. Future studies with larger and more diverse samples may benefit from incorporating multiple testosterone indices (e.g., hair, diurnal, and reactivity measures) to examine whether these indices are differentially related to CPB and protective parenting.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":"e70160"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkey Meltdowns: Do Tantrums Influence Maternal Investment in Bearded Capuchin Monkeys?","authors":"Mábia B Cera, Guilbert Araujo, Helena F Lima, Mateus Oka, Vinícius Andrietta, Patrícia Izar","doi":"10.1002/dev.70157","DOIUrl":"https://doi.org/10.1002/dev.70157","url":null,"abstract":"<p><p>Tantrums are widely discussed in human development literature and are typically defined as displays of frustration or anger. In behavioral ecology, they are hypothesized to function as a strategy for securing greater maternal investment. Infant primates often exhibit tantrums when their attempts to obtain maternal care are rejected. We investigated whether these displays influence maternal investment in a wild population of capuchin monkeys (Sapajus libidinosus) at Fazenda Boa Vista, Brazil. We analyzed 213 h of footage of 12 infants filmed over their first 18 months of life using focal animal sampling and identified 550 infant solicitation events for nursing and transportation. Maternal rejection was rare (N = 47) but increased significantly with age. Infants displayed tantrums after most rejections (N = 31), but their occurrence did not vary significantly with age and had no significant effect on the likelihood of obtaining maternal care. Infant solicitations declined significantly with age, suggesting that maternal investment decreases as infants' behavior changes. Our findings suggest that tantrums may reflect the challenges infants face during the transition to independence associated with weaning rather than an effective strategy for securing additional maternal care. By not reinforcing tantrums, mothers may facilitate infants' gradual adjustment and shift toward greater independence.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":"e70157"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between New Mothers' Neural Reward Response and Perceptions of Their Own Infant.","authors":"Kaylin E Hill, Julia Garon-Bissonnette, McKenzie N Greene, Emilia F Cárdenas, Maya Jackson, Samantha Pegg, Kathryn L Humphreys, Autumn Kujawa","doi":"10.1002/dev.70164","DOIUrl":"https://doi.org/10.1002/dev.70164","url":null,"abstract":"<p><p>Reward responsiveness is a key process in social motivation and may support important caregiver social processes such as caregiver perceptions of their infant. Reward responsiveness is commonly measured at the neural level via the reward positivity (RewP), an event-related potential derived from electroencephalogram (EEG), in both monetary and social domains. The current study examined whether and to what degree the RewP, in response to monetary and personally salient social reward feedback, relates to mothers' perceptions of their infant during the early postpartum period (mean = 9.23 weeks post birth). Mothers (N = 91) completed two reward tasks while continuous EEG was recorded and provided descriptors of their infant's personality. The RewP was measured in response to a novel social incentive delay task (i.e., \"winning\" allowed participants to view a photo of their own infant) as well as a standard monetary incentive delay task. Both the social RewP and monetary RewP shared positive associations with mothers' perceptions of their infant (social: β = 0.39, 95% CI [0.07, 0.71], p = 0.016; monetary: β = 0.39, 95% CI [0.07, 0.71], p = 0.017). Together, results suggest mothers' neural motivational systems are related to how they perceive their child, with implications for understanding caregiver functioning and the caregiver-child relationship as context for child development.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":"e70164"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error-Related Brain Activity Moderates the Association Between Interpersonal Stressor Exposure and Both Current and Future Anxiety Symptoms in Adolescent Girls","authors":"Alannah R. Srsich,&nbsp;George M. Slavich,&nbsp;Greg Hajcak,&nbsp;Brady D. Nelson","doi":"10.1002/dev.70150","DOIUrl":"10.1002/dev.70150","url":null,"abstract":"<div>\u0000 \u0000 <p>Anxiety disorders are one of the most common forms of psychopathology and often emerge in childhood and adolescence. The error-related negativity (ERN) is a potential neural vulnerability marker for anxiety. Although some studies have indicated that the ERN interacts with stressful life events to predict anxiety, these studies have only examined natural disasters or adult life stress, and it is thus unclear whether this vulnerability marker moderates the association between early life stressors and the development of psychopathology. To investigate, we assessed the past year stressor exposure of 180 nine- to 17-year-old girls using the Stress and Adversity Inventory for Adolescents, and self-report anxiety symptoms at baseline and 3 years later. At baseline, participants also completed a flanker task while electroencephalography was recorded to measure the ERN. As hypothesized, the ERN moderated the association between chronic interpersonal stressor exposure and both concurrent and 3-year follow-up anxiety symptoms. Specifically, greater chronic interpersonal stress was related to more concurrent and future anxiety symptoms, and this association was strongest in the context of a larger ERN. Error-related brain activity is thus an important moderating factor in the relation between chronic interpersonal stressor exposure and the development of anxiety symptoms across adolescence.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Touch Modulates Gamma-Band Network Dynamics in the Infant Brain","authors":"Silvia Polver,&nbsp;Margaret Addabbo,&nbsp;Chiara Turati,&nbsp;Eleonora Arrigoni,&nbsp;Ermanno Quadrelli,&nbsp;Alberto Pisoni,&nbsp;Hermann Bulf","doi":"10.1002/dev.70151","DOIUrl":"10.1002/dev.70151","url":null,"abstract":"<div>\u0000 \u0000 <p>Touch is a foundational sensory modality in early development, playing a pivotal role in shaping social, emotional, and cognitive functions. This study focused on EEG data from 8-month-old infants to investigate the neural networks underlying the processing of naturalistic hand-to-hand touch—both felt and observed. Unlike prior research in which infants were presented with artificial stimuli, we employed ecologically valid, caregiver-like tactile interactions to better capture real-world dynamics. Our findings reveal that felt touch elicited widespread, highly coordinated gamma-band activity across sensory and higher-order cortical areas, supporting early integration of bodily experiences with attentional and perceptual systems. Observed touch, while activating a more localized somatosensory network, still demonstrated distinct gamma connectivity, consistent with early self-other differentiation. A control condition involving observed failed contact elicited increased frontal and temporal activity, possibly reflecting expectancy violation and heightened attentional demands. These results underscore the significance of touch in scaffolding early neural architecture, especially within sensorimotor and social–cognitive domains. Furthermore, our findings highlight the value of analyzing multiple frequency bands beyond traditional μ rhythm desynchronization to understand infant mirroring mechanisms. Importantly, this study advances our understanding of how early tactile experiences may shape the developing connectome, revealing gamma oscillations as a marker of sensorimotor processing and emerging intersubjective awareness.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preconception Exposure to Chronic Stressors Influences Pair-Bonding Quality and Promotes Proximity-Based Parenting Styles in Adult Prairie Voles (Microtus ochrogaster)","authors":"W. Tang Watanasriyakul","doi":"10.1002/dev.70145","DOIUrl":"10.1002/dev.70145","url":null,"abstract":"<div>\u0000 \u0000 <p>The transition to parenthood, while exciting, can be a period of significant stress. Chronic stress is linked to parental mental health issues, interparental conflict, and poor parenting, all factors that contribute to adverse offspring outcomes. Unlike traditional rodent models that focus primarily on maternal care, the current study utilized the socially monogamous and biparental prairie vole (<i>Microtus ochrogaster</i>) to investigate how chronic preconception stress influences parental affect, pair-bonding, and parenting in both parents. Breeding pairs were assigned to either a stress exposure group, which underwent a 4-week chronic stress protocol (social isolation + mild unpredictable environmental stressors) prior to conception, or a no stress group (control). Chronic stress exposure did not induce anxiety- or depressive-like phenotypes or alter related hypothalamic activation in parents. However, stress-exposed parents exhibited atypical pair-bonding dynamics and a shift toward a proximity-based parenting style. Exploratory analyses revealed evidence for the intergenerational transmission of affective behavior and central oxytocin activation, primarily through maternal influences. In conclusion, chronic preconception stress can subtly disrupt the parental unit by altering pair-bonding quality and caregiving behavior, with potential consequences for offspring development. These findings highlight the family unit as a critical target for understanding and mitigating the intergenerational effects of stress.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}