Developmental psychobiology最新文献

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Early Postnatal Androgenic Activity Inhibition Produces Differential Long-Term Alterations in Anxiety-Like Behavior in Young Adult Male and Female Wistar Rats 出生后早期雄激素活性抑制在年轻成年雄性和雌性Wistar大鼠的焦虑样行为中产生不同的长期改变。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-10-15 DOI: 10.1002/dev.70211
Ulises Primo, Jose Manuel Fernández-García, Rocío García-Úbeda, Paloma Collado, Beatriz Carrillo, Helena Pinos
{"title":"Early Postnatal Androgenic Activity Inhibition Produces Differential Long-Term Alterations in Anxiety-Like Behavior in Young Adult Male and Female Wistar Rats","authors":"Ulises Primo,&nbsp;Jose Manuel Fernández-García,&nbsp;Rocío García-Úbeda,&nbsp;Paloma Collado,&nbsp;Beatriz Carrillo,&nbsp;Helena Pinos","doi":"10.1002/dev.70211","DOIUrl":"10.1002/dev.70211","url":null,"abstract":"<p>Sex differences in anxiety-like behavior are influenced by gonadal steroids, yet the contribution of early postnatal androgen signaling and testosterone metabolic pathways to the long-term organization of these behaviors remains unclear. Wistar male and female rats received daily s.c. injections from postnatal day (P) 1 to P5 of vehicle, flutamide, letrozole, or finasteride. In young adult animals, locomotor activity and anxiety-like behavior were evaluated via the open field test (OFT) and elevated plus maze (EPM). Females showed higher locomotor activity than males in both tests. Control females showed a less anxiety-like profile than control males in the EPM. Flutamide treatment abolished sex differences in EPM open-arm anxiety-related measures and increased the number of freezing episodes and their duration in the OFT. However, finasteride treatment preserved the sex differences observed in the control groups in anxiety-like measures. Finally, aromatase inhibition abolished sex differences in anxiety-like behavior and induced an anxiolytic-like effect in males, as indicated by increased open-arm entries relative to control males. These findings indicate that androgen-related pathways during early postnatal life shape adult anxiety-like behavior in a sex-dependent and pathway-dependent manner and highlight aromatization as a key mechanism in the organization of EPM behavioral outcomes in males.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Genetic Variability in OXTR Polymorphism and Infant Reactivity to Ostracism Experiences” 修正“OXTR多态性的遗传变异与婴儿对排斥经历的反应”。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-10-11 DOI: 10.1002/dev.70210
{"title":"Correction to “Genetic Variability in OXTR Polymorphism and Infant Reactivity to Ostracism Experiences”","authors":"","doi":"10.1002/dev.70210","DOIUrl":"10.1002/dev.70210","url":null,"abstract":"<p>Testa, A., E. Quadrelli, V. Dall'Olio, et al. 2026. Genetic Variability in <i>OXTR</i> Polymorphism and Infant Reactivity to Ostracism Experiences. <i>Developmental Psychobiology</i>, 68, no. 4: e70175. https://doi.org/10.1002/dev.70175</p><p>In the originally published version of this article, the authors’ given names and surnames were erroneously transposed. The correct author name order appears below. The online version has been corrected accordingly.</p><p>Alessia Testa (https://orcid.org/0009-0008-9602-7828), Ermanno Quadrelli (https://orcid.org/0000-0002-6834-0912), Valentina Dall'Olio, Laura Tizzoni, Paolo Peterlongo (https://orcid.org/0000-0001-6951-6855), Hermann Bulf (https://orcid.org/0000-0003-4121-1341), Chiara Turati (https://orcid.org/0000-0001-7496-1830).</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Exposure to Witnessed Social Defeat Stress Induces Sex-Specific Disruptions in Juvenile Social Play Behavior in Rats 母鼠暴露于目睹的社会失败压力下,会导致幼鼠社会游戏行为的性别特异性中断。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-10-06 DOI: 10.1002/dev.70205
Andrew Justin Taylor, Robinson Carrasco-Gutiérrez, Arabia Olea-Araya, Pablo R. Moya, Alexies Dagnino-Subiabre
{"title":"Maternal Exposure to Witnessed Social Defeat Stress Induces Sex-Specific Disruptions in Juvenile Social Play Behavior in Rats","authors":"Andrew Justin Taylor,&nbsp;Robinson Carrasco-Gutiérrez,&nbsp;Arabia Olea-Araya,&nbsp;Pablo R. Moya,&nbsp;Alexies Dagnino-Subiabre","doi":"10.1002/dev.70205","DOIUrl":"10.1002/dev.70205","url":null,"abstract":"<div>\u0000 \u0000 <p>Stressing rodent dams during lactation can impair offspring neurodevelopment, altering behavioral and physiological outcomes. Witnessed social defeat stress (WSDS) is a paradigm in which a juvenile or adult rodent observes aggressive encounters, affecting stress physiology and behavior. We developed a novel early-life stress model by exposing lactating rat dams to WSDS and assessed its impact on juvenile social behavior and stress-related physiology. At postnatal day 24, same-sex, age-matched pairs of offspring were tested for social play by scoring pouncing (play initiation), pinning, chasing, and evading. Locomotor activity was assessed in the open field on the same day. After behavioral testing, adrenal cortex weight was measured as an indirect marker of stress-related physiology. Maternal WSDS exposure was associated with a significant sex × WSDS interaction in pouncing behavior, with reduced pouncing in juvenile males, whereas no comparable effect was observed in females. WSDS exposure also increased adrenal cortex weight overall, although the sex × WSDS interaction for this measure was not significant. The reduction in pouncing was characterized by substantial within-group variability, and randomization-based sensitivity analysis indicated that the statistical significance of the sex × WSDS interaction was sensitive to focal-animal assignment. These findings suggest that maternal WSDS exposure may produce a specific and variable alteration in social play initiation, together with changes in stress-related physiology, during early juvenile development. This model may provide a useful framework for investigating how maternal psychosocial stress influences offspring behavioral and physiological development.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Depression, Childhood Resting-State Brain Connectivity, and Adolescent Depression During the COVID-19 Outbreak COVID-19爆发期间母亲抑郁、儿童静息状态大脑连通性和青少年抑郁
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-09-30 DOI: 10.1002/dev.70209
Pan Liu, Matthew R. J. Vandermeer, Andrew R. Daoust, Haley E. Green, Ola Mohamed Ali, Kasey Stanton, Kate L. Harkness, Deanna M. Barch, Marc F. Joanisse, Elizabeth P. Hayden
{"title":"Maternal Depression, Childhood Resting-State Brain Connectivity, and Adolescent Depression During the COVID-19 Outbreak","authors":"Pan Liu,&nbsp;Matthew R. J. Vandermeer,&nbsp;Andrew R. Daoust,&nbsp;Haley E. Green,&nbsp;Ola Mohamed Ali,&nbsp;Kasey Stanton,&nbsp;Kate L. Harkness,&nbsp;Deanna M. Barch,&nbsp;Marc F. Joanisse,&nbsp;Elizabeth P. Hayden","doi":"10.1002/dev.70209","DOIUrl":"10.1002/dev.70209","url":null,"abstract":"<p>Adolescents of mothers with a history of depression are at increased risk for developing depression themselves. These adolescents may have been especially vulnerable to depression under conditions of stress, such as the beginning of the COVID-19 pandemic. To understand the complex processes involved in the transmission of maternal depression risk to adolescent offspring in the context of stress, we examined potential mediating and moderating factors that link maternal depression history and offspring depressive symptoms, including resting-state functional connectivity (rs-FC) and mothers’ depressive symptoms, in 85 adolescents during the pandemic. Adolescents’ prepandemic rs-FC between the posterior and anterior cingulate cortices (PCC–ACC) moderated the association between maternal depression history and adolescents’ symptoms during the pandemic, such that maternal depression history predicted adolescents’ symptoms only in youths with heightened PCC–ACC rs-FC. Mothers’ depressive symptoms during the pandemic mediated and moderated the link between maternal depression history and adolescents’ symptoms. Mothers with a history of depression had greater depressive symptoms early during the pandemic, which were further associated with offspring depressive symptoms. Additionally, maternal depression history predicted depressive symptoms in adolescents whose mothers had lower depressive symptoms during the pandemic. Findings speak to the mediating and moderating processes in the transmission of maternal depression risk to adolescent offspring in the context of the pandemic.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic Programming of Stress-Response Systems: A Systematic Review of How Early Life Stress Shapes Developmental Trajectories of Mental Health 应激反应系统的表观遗传编程:早期生活压力如何塑造心理健康发展轨迹的系统综述
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-09-27 DOI: 10.1002/dev.70207
Nesrullah Okan, Nihat Köse
{"title":"Epigenetic Programming of Stress-Response Systems: A Systematic Review of How Early Life Stress Shapes Developmental Trajectories of Mental Health","authors":"Nesrullah Okan,&nbsp;Nihat Köse","doi":"10.1002/dev.70207","DOIUrl":"https://doi.org/10.1002/dev.70207","url":null,"abstract":"<div>\u0000 \u0000 <p>Early life stress (ELS) is a critical environmental factor influencing developmental trajectories of behavioral and emotional regulation. Increasing evidence suggests that such experiences can alter biological systems during sensitive developmental periods through epigenetic processes. This systematic review aims to synthesize empirical human studies examining how ELS contributes to the developmental programming of mental health via epigenetic regulation of stress-response systems. This systematic review was conducted in accordance with PRISMA 2020 guidelines. A comprehensive search of PubMed/MEDLINE, Web of Science, Scopus, and PsycINFO databases was performed for studies published up to March 2026. Eligible studies included empirical human research investigating associations between ELS, epigenetic mechanisms (primarily DNA methylation), and mental health-related outcomes across developmental stages. A total of 14 studies met inclusion criteria and were synthesized using a qualitative approach. Findings indicate that ELS is associated with persistent epigenetic modifications in key genes regulating stress-response systems, particularly within the hypothalamic–pituitary–adrenal (HPA) axis. Altered DNA methylation patterns in genes such as NR3C1, FKBP5, SLC6A4, MAOA, and ANK3 were consistently linked to developmental alterations in emotional regulation and increased vulnerability to psychiatric conditions, including depression, anxiety disorders, and post-traumatic stress disorder. Importantly, evidence highlights early childhood as a sensitive developmental window during which environmental inputs exert stronger and more enduring biological effects. Some studies further suggest that epigenetic profiles may show partial plasticity in response to environmental or therapeutic changes across development. This review supports the concept that ELS contributes to the developmental programming of mental health through epigenetic mechanisms affecting stress-response systems. These findings underscore the importance of timing and environmental context in shaping long-term behavioral outcomes. However, the existing literature remains limited by methodological heterogeneity, including variability in developmental stages, tissue types, and measurement approaches. Future research should prioritize longitudinal and developmentally informed designs to better capture the dynamic interplay between environment, biology, and behavior across the lifespan.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
It Takes Two to Regulate: Neural and Behavioral Synchrony Relate to Child Externalizing and Internalizing Profiles 需要两个人来调节:与儿童外化和内化档案有关的神经和行为同步。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-09-23 DOI: 10.1002/dev.70203
Abigél Miskolczi, Ying Li, Ö. Ece Demir-Lira
{"title":"It Takes Two to Regulate: Neural and Behavioral Synchrony Relate to Child Externalizing and Internalizing Profiles","authors":"Abigél Miskolczi,&nbsp;Ying Li,&nbsp;Ö. Ece Demir-Lira","doi":"10.1002/dev.70203","DOIUrl":"10.1002/dev.70203","url":null,"abstract":"<p>Parent–child interactions contribute to children's behavioral development and may buffer against psychopathology. Less is known about behavioral and neural alignment's association to development. Therefore, we examined behavioral and neural synchrony's relation to child behavioral problems. Parent–child behavioral synchrony was measured by Mutually Responsive Orientation coding, capturing coordinated routines, mutual cooperation, emotional ambiance, and harmonious communication. Functional near-infrared spectroscopy hyperscanning was used to measure parent–child neural synchrony in the temporoparietal junction (TPJ) and the dorsolateral prefrontal cortex (dlPFC). Children's externalizing and internalizing behaviors were assessed using the Child Behavior Checklist. 39 dyads (children aged 4 to 6) participated. Mutual cooperation positively related to externalizing and internalizing behaviors. Coordinated routines negatively related to externalizing behaviors. Neural synchrony between child TPJ and parent left dlPFC positively, whereas between child regions and parent right dlPFC negatively related to child externalizing behaviors. Neural synchrony between child regions and parent left dlPFC positively, whereas between child left-hemisphere and parent TPJ negatively related to child internalizing behaviors. Combining behavioral and neural synchrony did not improve model fit beyond considering each level alone. Our results suggest that distinct synchrony components uniquely relate to child psychopathology. Synchrony type matters more than amount, with flexible, turn-taking interactions being particularly beneficial.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trajectories of Caregiver Psychosocial Stress and Child Psychiatric Risk: The Role of Preterm Birth and Racial Socioenvironmental Inequity 照顾者心理社会压力和儿童精神疾病风险的轨迹:早产和种族社会环境不平等的作用。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-09-23 DOI: 10.1002/dev.70198
Berenice Anaya, Rachel E. Lean, Anna Constantino-Pettit, Christopher D. Smyser, Cynthia E. Rogers
{"title":"Trajectories of Caregiver Psychosocial Stress and Child Psychiatric Risk: The Role of Preterm Birth and Racial Socioenvironmental Inequity","authors":"Berenice Anaya,&nbsp;Rachel E. Lean,&nbsp;Anna Constantino-Pettit,&nbsp;Christopher D. Smyser,&nbsp;Cynthia E. Rogers","doi":"10.1002/dev.70198","DOIUrl":"10.1002/dev.70198","url":null,"abstract":"<div>\u0000 \u0000 <p>The current study examines trajectories of caregiver psychosocial stress in a large (<i>N</i> = 288) and representative longitudinal sample of families impacted by very preterm (VPT) birth, including a group of VPT infants with white matter injury (WMI) and a group of term control (TC) families followed from birth to age 9/10. We examine trajectories of caregiver psychosocial stress as a function of caregiver race, the extent to which social determinants of health (SDoH) factors mitigate or exacerbate differences in caregiver psychosocial stress trajectories, and whether these trajectories relate to child psychopathology outcomes. Using multigroup (birth group: TC, VPT, and WMI) latent growth models, we show that trajectories of caregiver anxiety and total stress, but not depression, varied across birth groups. Specifically, caregivers of VPT and WMI infants reported higher levels of early anxiety and total stress (birth and 2 years postpartum) compared to TC caregivers, but these early high levels of anxiety and stress significantly decreased over time. We also show distinct trajectories of anxiety in Black VPT caregivers compared to White VPT caregivers as a function of health insurance status, such that White VPT caregivers using public insurance experienced more persistent anxiety levels over time while Black VPT caregivers seemed to leverage both public and private insurance. We also found longitudinal associations between caregiver depression and child psychopathology in all birth groups, reiterating the critical need for care and intervention during the postpartum period.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress and Sleep in Adolescence: The Interactive Effects of Skin Conductance Level Reactivity and Parental Psychological Control 青少年压力与睡眠:皮肤电导水平反应与父母心理控制的交互作用。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-09-21 DOI: 10.1002/dev.70202
Stephen A. Erath, Peggy S. Keller, Zeynep Su Altinoz, Lauren E. Philbrook, Mona El-Sheikh
{"title":"Stress and Sleep in Adolescence: The Interactive Effects of Skin Conductance Level Reactivity and Parental Psychological Control","authors":"Stephen A. Erath,&nbsp;Peggy S. Keller,&nbsp;Zeynep Su Altinoz,&nbsp;Lauren E. Philbrook,&nbsp;Mona El-Sheikh","doi":"10.1002/dev.70202","DOIUrl":"10.1002/dev.70202","url":null,"abstract":"<div>\u0000 \u0000 <p>Adolescents are vulnerable to poor sleep, and both individual and environmental factors predict youth sleep problems. The present study examined the independent and interactive associations of adolescent sympathetic nervous system reactivity and experiences of parenting with multiple aspects of their sleep. Participants were 579 late adolescents (<i>M</i><sub>age</sub> = 17.14 years, 47.3% males, 52.7% females; 62.7% White, 37.3% Black). Sympathetic reactivity was measured via skin conductance level reactivity in response to a lab-based stressor, and participants reported on experiences of parental psychological control. Adolescent sleep was assessed both objectively through actigraphy and subjectively from self-report. Structural equation models demonstrated a consistent pattern of interaction effects, such that higher adolescent skin conductance level reactivity predicted better actigraphy-derived sleep 1 year later at low levels of paternal psychological control, but worse actigraphy-derived sleep at high levels of paternal psychological control. There were no independent or interactive effects for mothers’ parenting. Findings are consistent with biological sensitivity to context theory and indicate that high skin conductance level reactivity may reflect appropriate engagement with the environment in low-stress contexts but lead to wear and tear of bioregulatory systems in contexts of high stress, eroding sleep.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fathers’ Childcare Success and Maternal Parenting Stress: A Comparative Study of Families With and Without Children Having Neurodevelopmental Disabilities 父亲育儿成功与母亲育儿压力:有与无神经发育障碍儿童家庭的比较研究。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-09-20 DOI: 10.1002/dev.70201
Shiori Ishida, Tomone Takahashi, Aimi Kinoshita, Hisato Igarashi
{"title":"Fathers’ Childcare Success and Maternal Parenting Stress: A Comparative Study of Families With and Without Children Having Neurodevelopmental Disabilities","authors":"Shiori Ishida,&nbsp;Tomone Takahashi,&nbsp;Aimi Kinoshita,&nbsp;Hisato Igarashi","doi":"10.1002/dev.70201","DOIUrl":"10.1002/dev.70201","url":null,"abstract":"<p>Paternal engagement has been described as a relational process that redistributes caregiving responsibilities and strengthens family resilience and function. This study investigated the association between fathers’ childcare success and maternal parenting stress by comparing families raising children with neurodevelopmental disabilities (ND) with those raising typically developing (TD) children. Fifty-three fathers of children with ND and 206 fathers of TD children completed online surveys on parenting self-efficacy, childcare knowledge, involvement, communication with their spouse, and perceived social support. In paired surveys, spouses reported on parenting stress. Structural equation modeling indicated that in both groups, higher paternal childcare success was significantly associated with lower maternal stress (ND: <i>β</i> = −0.42, <i>p</i> &lt; 0.05; TD: <i>β</i> = −0.39, <i>p</i> &lt; 0.001). However, the contributing factors differed; in TD families, paternal role awareness, father–child relationship, and spousal relationship were most strongly related to fathers’ childcare success, whereas these associations were less prominent in ND families. These findings highlight the importance of interventions that address fathers’ psychological traits as well as the specialized skills and knowledge required for parenting children with ND to enhance family functioning and parental well-being.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal Maternal Stress and Infant Gut Microbiome in Human and Animal Studies: A Comprehensive Systematic Review 产前母亲压力和婴儿肠道微生物组在人类和动物研究:一个全面的系统综述。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-09-15 DOI: 10.1002/dev.70199
Galina V. Khafizova, Harini Kanamarlapudi, Jessica Garcia, Aidan Nichols, Arfa Ali, Hechmi Kilani, Elena L. Grigorenko
{"title":"Prenatal Maternal Stress and Infant Gut Microbiome in Human and Animal Studies: A Comprehensive Systematic Review","authors":"Galina V. Khafizova,&nbsp;Harini Kanamarlapudi,&nbsp;Jessica Garcia,&nbsp;Aidan Nichols,&nbsp;Arfa Ali,&nbsp;Hechmi Kilani,&nbsp;Elena L. Grigorenko","doi":"10.1002/dev.70199","DOIUrl":"10.1002/dev.70199","url":null,"abstract":"<div>\u0000 \u0000 <p>The infant gut microbiome plays a fundamental role in immune maturation, metabolic programming, and neurodevelopment, with early microbial colonization representing a sensitive period for long-term health outcomes. Maternal factors during pregnancy powerfully modulate infant microbiome assembly; however, the specific effects of prenatal stress exposure (PSE) on offspring gut microbial communities remain incompletely understood. Here, we present a cross-species systematic review, the first of this scale, examining associations between prenatal stress and offspring gut microbiome composition. Searches of PubMed (MEDLINE), Scopus, and PsycINFO identified 33 review-eligible articles published over the past two decades. Across studies, we evaluated stressor characteristics, offspring age at microbiome assessment, and methodological issues relevant to result interpretation. Although the literature is heterogeneous and reports mixed findings, several recurring patterns emerge. Most studies report an increased relative abundance of Proteobacteria and reduced levels of early-life beneficial taxa from the Actinobacteria and Firmicutes phyla following PSE, driving a negative shift toward a pro-inflammatory profile and early-life dysbiosis. At the genus level, decreases in <i>Bifidobacterium</i>, <i>Lactobacillus</i>, <i>Muribaculum</i>, and <i>Parabacteroides</i> are frequently observed, alongside increases in <i>Klebsiella, Enterobacter</i>, and <i>Sutterella</i>, taxonomic shifts that disrupt gut homeostasis and are associated with increased lifelong risks for metabolic, inflammatory, and neurodevelopmental disorders. Differences between human cohorts and animal models regarding alpha diversity patterns and beta diversity clustering are identified. Finally, we explore methodological limitations in the existing literature and discuss recent advances and recommendations to support the continued development of research on prenatal stress, the gut microbiome, and developmental outcomes. Altogether, our study demonstrates that while PSE acts as a powerful upstream ecological modifier of the early-life gut microbiota across species, its long-term biological embedding is heavily moderated by sex, developmental timing, and specific environmental context.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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