Developmental psychobiology最新文献

{"title":"Investigating Physiology-Behavior Associations for Youth During Parent–Child Conflict Discussions","authors":"Salome Vanwoerden,&nbsp;Vera Vine,&nbsp;Amy L. Byrd,&nbsp;Kathryn B. Altman,&nbsp;J. Richard Jennings,&nbsp;Stephanie D. Stepp","doi":"10.1002/dev.70149","DOIUrl":"10.1002/dev.70149","url":null,"abstract":"<p>Adolescents’ observed affective behavior is associated with patterns of concurrent physiological responding, which explain clinically relevant outcomes. Few studies have elucidated the physiology-behavior association during the developmentally salient context of conflict with parents. The current study evaluated associations between respiratory sinus arrythmia (RSA) activity and observed youth affective behavior during parent–child conflict. We took a contextually informed approach to address limitations of past research with a clinical sample of parent–child dyads (<i>N</i> = 162, <i>M</i>_youthage = 12.03 (0.92) years; 46.9% female; 42% White and non-Hispanic/Latinx; 40.7% Black; 16.7% multiracial). Dyads completed a conflict discussion during which youths’ affective behaviors were observationally coded. Additionally, we measured youths’ RSA and subjective affect as well as parents’ negative behavior. Youths’ angry/defiant behavior was predicted by faster RSA withdrawal, increases in subjective negative affect, and more negative parent behavior, whereas youths’ sad/distressed and positive engagement behaviors were predicted solely by subjective negative affect and negative parent behavior, respectively. Findings underscore the importance of taking context into account to understand the physiology-behavior association among youth in developmentally salient interactions, which has implications for enhancing etiological models of psychopathology.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effects of Early Psychosocial Factors and Polygenic Risk for Smoking: a Cross-Sectional Analysis of a Sample of Older Adults in the United States","authors":"Walter G. Dyer,&nbsp;Sung-Ha Lee,&nbsp;Hannah Wilding,&nbsp;Brianna Sutara,&nbsp;Harold H. Lee","doi":"10.1002/dev.70152","DOIUrl":"10.1002/dev.70152","url":null,"abstract":"<p>Genetic influence on smoking may be modified by negative early psychosocial factors (EPFs). However, few studies have examined this interaction. We hypothesized that negative EPFs will exacerbate the association between genetic risk for smoking and ever smoking. We used data on European Americans (EA) and African Americans (AA) from the Health and Retirement Study (HRS). Polygenic score for “ever smoking” (PGS_smoking) was assessed using PRSice from a 2010 GWAS conducted by the Tobacco and Genetics Consortium. We operationalized PGS_smoking as a binary variable: top 25% versus the rest. Ever smoking was assessed by asking participants if they had smoked 100 or more cigarettes in their lifetimes. EPFs included education levels of mother or father, perceived financial status, maternal warmth, and stressful events before age 18. We used logistic regression to assess the odds ratio (OR) for PGS_smoking, EPFs, and their interaction terms in relation to ever smoking, adjusting for age, gender, and the five principal components. Among the 6969 EA participants (mean age: 74.3 years, 57% women), 55% reported ever smoking. Among the 2141 AA participants (mean age: 59.6, 67.3% women), 61.1% reported ever smoking. Within the AA sample, high genetic risk (top 25%) was associated with a 18% higher likelihood of ever smoking for AA (95% confidence interval [CI] = 0.91–1.52). Within the EA sample, high genetic risk was associated with a 25% higher likelihood of ever smoking (95% CI = 1.11–1.41), and low maternal warmth and PGS_smoking showed significant additive interactions to increase odds of ever smoking. The expected OR for those exposed to both high genetic risk and low maternal warmth exceeded the sum of their individual effects (relative risk due to interaction [RERI] = 0.42 [0, 0.85], <i>p</i> = 0.03), resulting in 75% higher odds of smoking compared to individuals with none of these exposures. These synergistic effects observed within the EA sample were not observed within the AA sample. Several EPFs and PGS_smoking were associated with increased odds of ever smoking. Among EA participants, low maternal warmth was associated with exacerbated genetic predisposition to smoking. No synergy between EPFs and genetic risk was observed for AA participants.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Maternal Stress and Weak Handedness in Early Childhood: The Iowa Flood Study","authors":"Jad Hamaoui,&nbsp;Hao Zhang,&nbsp;Suzanne King,&nbsp;Natalie Castellanos-Ryan","doi":"10.1002/dev.70143","DOIUrl":"10.1002/dev.70143","url":null,"abstract":"<p>Weak handedness is frequently observed in individuals with neurodevelopmental and psychiatric disorders. Although birth-related stressors, such as prematurity, have been shown to contribute to this association, the influence of early prenatal maternal stress (PNMS) remains under-explored. This study examined the trimester-specific effects of disaster-related PNMS on handedness development using rare longitudinal data from the 2008 Iowa Flood Study. Pregnant women exposed to major flooding were assessed for objective (hardship severity) and subjective (psychological distress) PNMS and postnatal maternal depression, and their children's handedness was reported at 60 months (<i>n</i> = 217, 45.6% female). Path analyses revealed distinct trimester-dependent associations between PNMS and offspring handedness. When stress exposure occurred during the first trimester, weak handedness in offspring was predicted by the child's sex, with male sex being associated with higher weak handedness (<i>β</i> = −0.29) only. In contrast, for third trimester exposure, higher objective PNMS was associated with higher weak handedness (<i>β</i> = −0.34), while the child's sex was no longer a significant predictor (<i>β</i> = 0.11). These findings suggest that PNMS influences the ontogenesis of handedness through trimester-specific mechanisms, potentially mediated by epigenetic modifications. Potential neurobiological mechanisms underlying these associations and their clinical implications for neurodevelopmental outcomes are discussed.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways Linking Community-Level Social Determinants of Health to Infant Biological Markers and Early Childhood Psychopathology: A Structural Equation Modeling Approach","authors":"Viviane Valdes,&nbsp;Ellen Jopling,&nbsp;Georgia F. Celestin,&nbsp;Leticia Sefia,&nbsp;Lara Pierce,&nbsp;Jennifer Near,&nbsp;Charles A. Nelson","doi":"10.1002/dev.70144","DOIUrl":"10.1002/dev.70144","url":null,"abstract":"<div>\u0000 \u0000 <p>We aimed to examine associations between multiple community-level social determinants of health and two biological markers: frontal alpha asymmetry (FAA) and telomere length (TL) in early childhood. We also probed pathways from community-level social determinants to biological markers and subsequent psychopathology symptoms. Using a longitudinal design, 211 families were followed during the first 2 years of life. Social determinants were assessed using US Census data, FAA using resting-state electroencephalogram, TL from infant saliva samples, and child psychopathology symptoms using the ITSEA. Statistical analyses included bivariate correlations (unadjusted and with false discovery rate adjustment for multiple comparisons) and SEM. For FAA, higher rates of uninsurance (healthcare) were associated with greater right lateralization at 2 months (<i>r</i> = −0.233, <i>p</i> = 0.028), and higher rates of food insecurity were also associated with greater right lateralization at 9 months (<i>r</i> = −0.250, <i>p</i> = 0.036); however, these associations were not significant after adjustment for multiple comparisons. In our SEM model, we found that both social determinants had paths to FAA (i.e., healthcare uninsurance rates to FAA at 2 months; food insecurity rates to FAA at 9 months), which had paths to child psychopathology symptoms at 2 years. Two community-level social determinants (greater poverty levels/lower home ownership rates) were significantly associated with shorter TL at 9 months (<i>r</i> = −0.395, <i>p</i> = 0.007; <i>r</i> = 0.293, <i>p</i> = 0.048), although only community poverty levels remained significant after adjustment for multiple comparisons. In the SEM model, community poverty levels had paths through TL at 9 months to child psychopathology symptoms at 2 years; home ownership rates only covaried with poverty levels. Distinct social determinant domains may influence markers of biological stress at specific time points. These findings underscore the importance of structural-level policies and early interventions addressing multiple aspects of the environment.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental Psychobiology Reviewer Recognition for 2025","authors":"","doi":"10.1002/dev.70119","DOIUrl":"https://doi.org/10.1002/dev.70119","url":null,"abstract":"","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147564711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Prenatal Stress Exposure Predicts Infant Sympathetic Nervous System and Affective Responses","authors":"Cecilia Martinez-Torteya,&nbsp;Amy K. Nuttall,&nbsp;G. Anne Bogat,&nbsp;Joseph S. Lonstein,&nbsp;Maria Muzik,&nbsp;Kevin J. Grimm,&nbsp;Douglas A. Granger,&nbsp;Alytia A. Levendosky","doi":"10.1002/dev.70140","DOIUrl":"10.1002/dev.70140","url":null,"abstract":"<p>Prenatal stress has broad detrimental consequences for neurodevelopment, with potential sensitive periods within gestation affecting specific developmental systems. We examined the effects of prenatal stress timing, level, and fluctuations on three markers of sympathetic nervous system activity: infant salivary alpha amylase (sAA), fear, and anger responses. In addition, we explored whether the effects of prenatal stress differed for boys and girls. We assessed 195 mother-infant dyads (45% girls) from an ethnically diverse and economically disadvantaged community sample. Women reported perceived stress weekly from gestational week 14 to delivery. Dyads completed 6-month postpartum in-person assessments in which infants’ behavioral responses to two stressful tasks were coded and saliva collected. Machine learning analyses revealed that sAA and fear responses were predicted by increases in stress during the early third trimester (31–32 weeks) while increases in stress levels during mid- (21 weeks) and late-gestation (38 weeks) predicted lower anger in response to a frustration task. Sex-specific analyses pointed to different sensitive periods for boys and girls. Our findings emphasize the importance of collecting granular data during pregnancy to identify the epochs during which stress exposure is most pernicious, as well as the usefulness of assessing multiple indicators of infant biobehavioral reactivity to better capture the full toll of prenatal stress exposure.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid and Enduring Associative Connections: Ontogenetic Differences in Minimal Conditions for Learning Transfer at 6 and 9 Months","authors":"Kimberly Cuevas,&nbsp;Amy E. Learmonth","doi":"10.1002/dev.70136","DOIUrl":"10.1002/dev.70136","url":null,"abstract":"<p>Associations can enhance memory flexibility by enabling infants to transfer learning from one cue to another. The present experiment combined sensory preconditioning and deferred imitation to investigate the minimal conditions under which 6- and 9-month-olds form associations between co-occurring stimuli without exogenous reinforcement and retain this information for at least 48 h. Six-month-olds demonstrated robust learning transfer 2 days after a single 1-min, 52-s exposure to two stationary puppets in their visual surround. A single 56-s exposure or two 56-s exposures on consecutive days were ineffective. Nine-month-olds showed learning transfer after substantially longer exposure that involved stimulus movement (15 min). Additionally, age-related differences emerged in the conditions that supported learning; 6-month-olds rapidly formed and retained associations following simultaneous exposure, whereas 9-month-olds did so only after sequential exposure. These findings highlight ontogenetic differences in the constraints of associative learning and are discussed in relation to domain-general learning mechanisms.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver Ethnic–Racial Socialization and Ethnic–Racial Minority Children's Psychological Adjustment: The Moderating Effect of Skin Conductance Level Reactivity to Exclusion","authors":"Qingfang Song,&nbsp;Casey Buck,&nbsp;Maria C. Lent,&nbsp;Grace Salloum,&nbsp;William Mkanta,&nbsp;Dianna Murray-Close","doi":"10.1002/dev.70141","DOIUrl":"10.1002/dev.70141","url":null,"abstract":"<div>\u0000 \u0000 <p>Caregiver ethnic–racial socialization (ERS) plays an important role in outcomes among ethnic–racial minority youth (ERMY), but mixed findings suggest that the impact of ERS may vary depending on additional factors such as physiological stress reactivity to exclusion. This study examined whether ERMY's skin conductance level reactivity (SCLR) to exclusion moderated the associations between caregiver ERS (cultural socialization, preparation for bias, and promotion of mistrust) and their psychological adjustment. A total of 83 children (51% Latinx; 49% Black/African American), aged 6–11 years (<i>M</i>_age = 8.82 years, SD = 1.54), and their caregivers participated in the study. Children completed Cyberball tasks eliciting experiences of exclusion while SCLR was assessed. Caregivers completed questionnaires to report ERS and children's psychosocial adjustment. All three dimensions of caregiver ERS were associated with greater externalizing problems among children who exhibited lower SCLR to exclusion. In addition, preparation for bias was related to lower adaptive skills among youth with low SCLR. In contrast, promotion of mistrust was related to lower externalizing problems, and preparation for bias was related to higher adaptive skills among children with higher SCLR. The findings support the goodness-of-fit model in understanding the impact of caregiver ERS in the context of children's physiological stress reactivity.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Hit Exposure to Lipopolysaccharide and Acetaminophen Alters Larval Zebrafish (Danio rerio) Swim Behavior.","authors":"Joshua A Herrington, Robert A Mans, Christopher Harshaw, Joshua Richardson, Jessica Tran, Jade Bender, Cynthia Ware","doi":"10.1002/dev.70138","DOIUrl":"https://doi.org/10.1002/dev.70138","url":null,"abstract":"<p><p>Acetaminophen (APAP) has been implicated in the etiology of developmental disorders. While rodent models have demonstrated lasting neurobehavioral changes following prenatal and/or perinatal exposure to APAP, few studies have examined such effects in zebrafish (Danio rerio), and none have done so in the translationally relevant context of systemic inflammation. Zebrafish eggs were treated with Escherichia coli-derived lipopolysaccharide (LPS) and/or APAP in the first 24 h postfertilization (hpf). At 96 hpf, larval behavior was recorded during a light/dark transition test. Results showed embryonic APAP exposure elevated swim velocity, with APAP-treated larvae displaying more activity than those not treated with APAP. We also found significant interaction between LPS and APAP exposures, with \"two-hit\" LPS + APAP larvae exhibiting increased activity relative to LPS- and APAP-only groups during the dark phase. APAP-treated larvae also exhibited greater activity than controls during the light phase. In addition, LPS + APAP larvae displayed significantly fewer clockwise relative to counterclockwise rotations compared to LPS-only larvae. To explore a potential mechanism underlying observed behavioral differences, we analyzed glycogen synthase kinase-3 (GSK-3) Y216+Y279 ɑ/β phosphorylation and total levels in homogenized whole-brain tissue. Unexpectedly, the ratio of pGSK-3/total GSK-3 was not affected by any treatments. Nevertheless, this study demonstrates the utility of zebrafish as a model for studying the combinatorial effects of exposures such as inflammation and APAP early in life.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":"e70138"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal High-Fat Diet and Neonatal LPS Exposure Prolong USV Sequences and Shift Call-Type Repertoires in Neonatal Rats.","authors":"Mansi Kamlesh Purohit, Ingrid Woo, Mouly Rahman, Sameera Abuaish, Patrick O McGowan","doi":"10.1002/dev.70142","DOIUrl":"10.1002/dev.70142","url":null,"abstract":"<p><p>Rodent pups emit ultrasonic vocalizations (USVs) to solicit maternal care, enhancing survival. Inflammatory stressors, such as maternal high-fat diet (mHFD) and neonatal lipopolysaccharide (nLPS) exposure, affect neonatal neurodevelopment and behavior. Although basic features of USVs are widely used to assess these impacts, their sonographic and syntax characteristics remain underexplored. We employed DeepSqueak, a deep learning system, for automated unsupervised USV classification and detailed analysis of temporal and syntax changes, comparing it to manual coding for call number, duration, and frequency. Offspring of Long Evans rat dams, fed a high-fat or control diet for three weeks premating and throughout gestation and lactation, received 0.05 mg/kg intraperitoneal nLPS or saline on postnatal days (PND) 3 and 5 (n = 5-6 per condition, total N = 41). On PND 7, USVs were recorded after a brief maternal separation. DeepSqueak yielded 97% concordance (p > 0.8 vs. manual); mHFD increased bout duration by 25% (p < 0.01), and nLPS increased calls per sequence by 30% (p < 0.05). DeepSqueak matched manual accuracy, with automated analysis revealing that mHFD and nLPS significantly prolonged sequence durations and altered syntax transition probabilities. These findings suggest that temporal and syntactic USV features are sensitive markers of early inflammatory stress.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 2","pages":"e70142"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}