Developmental psychobiology最新文献_第2页

Ganaxolone Therapy After Preterm Birth Restores Cerebellar Oligodendrocyte Maturation and Myelination in Guinea Pigs 早产后服用甘珀酸可恢复几内亚猪小脑少突胶质细胞的成熟和髓鞘化

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-08 DOI: 10.1002/dev.22554

Carlton L. Pavy, Julia C. Shaw, Rebecca M. Dyson, Hannah K. Palliser, Roisin A. Moloney, Ryan P. Sixtus, Mary J. Berry, Jonathan J. Hirst

{"title":"Ganaxolone Therapy After Preterm Birth Restores Cerebellar Oligodendrocyte Maturation and Myelination in Guinea Pigs","authors":"Carlton L. Pavy, Julia C. Shaw, Rebecca M. Dyson, Hannah K. Palliser, Roisin A. Moloney, Ryan P. Sixtus, Mary J. Berry, Jonathan J. Hirst","doi":"10.1002/dev.22554","DOIUrl":"10.1002/dev.22554","url":null,"abstract":"The postnatal environment is challenging for the preterm neonate with exposure to hypoxic and excitotoxic events, amplified by premature loss of placentally derived neurosteroids. Between preterm birth and term equivalent age (TEA), cerebellar development continues despite these challenges. We hypothesize that neurosteroid replacement therapy during this time will support optimal cerebellar development. Guinea pig sows delivered at term (∼69 days gestation) or were induced to deliver preterm (∼62 days), with preterm pups receiving ganaxolone or vehicle until TEA. Postnatal assessments comprised salivary cortisol (corrected postnatal age [CPA] 0, 7, 38), behavioral analysis (CPA7, 38), and tissue collection (CPA0 and CPA40). Neurodevelopmental markers (MBP, Olig2, and NeuN) were assessed in the cerebellum by immunohistochemistry, whereas RT-PCR was utilized to investigate key inhibitory/excitatory pathways and oligodendrocyte lineage markers. Following preterm birth, there was evidence of a hyperactive phenotype, increased salivary cortisol concentrations, and impaired myelination and oligodendrocyte maturation at the protein level. mRNA expressions of key inhibitory/excitatory pathways and myelin stability were also altered following preterm birth. Importantly, we showed that neurosteroid replacement therapy returns cerebellar development and behavior toward a term-like phenotype. Therefore, ganaxolone may reduce the vulnerability of the cerebellum to postnatal challenges arising from preterm birth.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meconium as an Analyte for Androgen Exposure: Analysis Through Varying Maternal-Fetal Biomarkers 作为雄激素暴露分析物的胎粪：通过不同的母胎生物标志物进行分析

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-08 DOI: 10.1002/dev.22550

Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline

{"title":"Meconium as an Analyte for Androgen Exposure: Analysis Through Varying Maternal-Fetal Biomarkers","authors":"Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline","doi":"10.1002/dev.22550","DOIUrl":"10.1002/dev.22550","url":null,"abstract":"<div>\u0000 \u0000 Meconium, the first stool produced by neonates, has been used as an analyte for exogenous fetal exposures. However, few studies have investigated the relationship between meconium and androgen exposure in utero. Here, we examine the associations of testosterone and dehydroepiandrosterone (DHEA) across maternal antenatal salivary testosterone, cord blood, meconium, and infant salivary testosterone. A total of 47 women with singleton, uncomplicated pregnancies, and their infants were included in this study. Participants were recruited from an academic obstetric clinic. Maternal saliva was collected at 36-weeks’ gestation. Cord blood and meconium were collected at birth. Infant salivary testosterone was collected at 1 and 4 weeks of age. Multivariate model results showed that meconium testosterone was associated with neonatal testosterone at 1 (F = 5.62, p = 0.029) and 4 weeks (F = 4.28, p = 0.048) postnatal age; no sex differences were detected. This study suggests meconium is a valuable tool for evaluating endogenous androgen exposure and should be used in future studies to investigate the fetal hormonal milieu.\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies 早期逆境对小脑结构和功能的影响--人类和动物研究的系统回顾

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-08 DOI: 10.1002/dev.22556

Annakarina Mundorf, Sarah A. Merklein, Laura C. Rice, John E. Desmond, Jutta Peterburs

{"title":"Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies","authors":"Annakarina Mundorf, Sarah A. Merklein, Laura C. Rice, John E. Desmond, Jutta Peterburs","doi":"10.1002/dev.22556","DOIUrl":"10.1002/dev.22556","url":null,"abstract":"Recent research has highlighted cerebellar involvement in cognition and several psychiatric conditions such as mood and anxiety disorders and schizophrenia. Attention-deficit/hyperactivity disorder and autism spectrum disorder have been linked to reduced cerebellar volume as well. Cerebellar alterations are frequently present after early adversity in humans and animals, but a systematic integration of results is lacking. To this end, a systematic literature search was conducted in PubMed, Web of Science, and EBSCO databases using the keywords “early adversity OR early life stress” AND “cerebellum OR cerebellar.” A total of 45 publications met the inclusion criteria: 25 studies investigated human subjects and 20 reported results from animal models. Findings in healthy subjects show bilateral volume reduction and decreased functional connectivity within the cerebellum and between the cerebellum and frontal regions after adversity throughout life, especially when adversity was assessed with the Childhood Trauma Questionnaire. In clinical populations, adults demonstrate increased cerebellar volume and functional connectivity after adversity, whereas pediatric patients show reduced cerebellar volume. Animal findings reveal cerebellar alterations without necessarily co-occurring pathological behavior, highlighting alterations in stress hormone receptor levels, cell density, and neuroinflammation markers. Cerebellar alterations after early adversity are robust findings across human and animal studies and occur independent of clinical symptoms.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight-Month-Old Infants Are Susceptible to the Auditory Continuity Illusion 八个月大的婴儿易受听觉连续性错觉影响

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-30 DOI: 10.1002/dev.22551

Ryoko Mugitani, Makio Kashino

{"title":"Eight-Month-Old Infants Are Susceptible to the Auditory Continuity Illusion","authors":"Ryoko Mugitani, Makio Kashino","doi":"10.1002/dev.22551","DOIUrl":"10.1002/dev.22551","url":null,"abstract":"The real world is full of noise and constantly overlapping sounds. However, our auditory system provides a solution to this, that is, the continuity illusion; when we hear a sound stream that is partially replaced by high-level noise, we can restore missing sound information and “fill in” the information as if it were smooth and continuous even against a background of noise. In the present study, we tested the preferences for familiar and novel melodies of 8-month-old infants after a 2-month memory retention interval following 1-week exposure to a specific melody. A preference for familiarity was seen not only when the melody was presented intact but also when it was periodically replaced by high-level noise, which elicits the continuity illusion in adults (Experiment 1). However, a trend toward preference for a novel melody was observed for stimuli periodically replaced by low-level noise that did not satisfy the ecological constraints for the elicitation of the illusion (Experiment 2). For the first time, this study showed that infants as young as 8 months of age are susceptible to the auditory continuity illusion. The study also revealed that the infants could recognize the melody they heard 2 months previously.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultural Values Influence the Developmental Trajectory of Resistance to Social Influence Over the Course of Adolescence 文化价值观影响青少年时期抵制社会影响的发展轨迹

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-19 DOI: 10.1002/dev.22530

Rui Pei, Elissa Kranzler, Emily B. Falk

引用次数: 0

Brief Report: An Examination of Curvilinear Relations Between Perceived Mother–Child Closeness and Maternal Hair Cortisol 简要报告：对感知到的母子亲密程度与母体毛发皮质醇之间曲线关系的研究

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-13 DOI: 10.1002/dev.22548

Kavya Swaminathan, Samantha MacDonald, Stacey Doan

{"title":"Brief Report: An Examination of Curvilinear Relations Between Perceived Mother–Child Closeness and Maternal Hair Cortisol","authors":"Kavya Swaminathan, Samantha MacDonald, Stacey Doan","doi":"10.1002/dev.22548","DOIUrl":"https://doi.org/10.1002/dev.22548","url":null,"abstract":"<div>\u0000 \u0000 Interpersonal closeness has important health benefits; however, recent work suggests that in certain contexts, closeness can come at a cost. In the current study, curvilinear relations between mother–child closeness and health (e.g., depressive and anxiety symptoms and hair cortisol concentrations [HCC]) were tested. Our sample consisted of 117 mother (Mage = 36.86) and child (Mage = 73.07 months, 50.86% male) dyads. A quadratic relationship between maternal perceived closeness with their child and self-reported depressive and anxiety symptoms, along with overall hair cortisol output, was hypothesized. Path analysis suggested that the quadratic term was predictive of maternal cortisol (β = 0.28, p = 0.001) and depression (β = 0.23, p = 0.014), such that both high and low perceived closeness predict greater maternal depressive symptoms and HCCs as compared to moderate levels of closeness. Results are discussed in terms of parenting support and burnout.\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review 注意缺陷多动障碍、大麻使用和内源性大麻素系统：范围综述

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-13 DOI: 10.1002/dev.22540

Jennie E. Ryan, Mitchell Fruchtman, Andrea Sparr-Jaswa, Amy Knehans, Brooke Worster

{"title":"Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review","authors":"Jennie E. Ryan, Mitchell Fruchtman, Andrea Sparr-Jaswa, Amy Knehans, Brooke Worster","doi":"10.1002/dev.22540","DOIUrl":"https://doi.org/10.1002/dev.22540","url":null,"abstract":"There is emerging evidence that the endocannabinoid system (ECS) plays a significant role in the pathophysiology of many psychiatric disorders, including attention deficit hyperactivity disorder (ADHD). Increasing evidence suggests that a number of neurobiological correlates between endogenous cannabinoid function and cognitive dysfunction are seen in ADHD, making the ECS a possible target for therapeutic interventions. Cannabis use and cannabis use disorder are more prevalent in individuals with ADHD, compared to the general population, and there is growing popular perception that cannabis is therapeutic for ADHD. However, the relationship between cannabis use and ADHD symptomology is poorly understood. Further understanding of the role of the ECS in ADHD pathophysiology and the molecular alterations that may be a target for treatment is needed. To further the science on this emerging area of research, this scoping review describes the preclinical and clinical evidence seeking to understand the relationship between the ECS and ADHD.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of Differential Prediction of Anxiety and Depression by Diurnal Alpha-Amylase and Cortisol in Development 发育过程中昼夜α-淀粉酶和皮质醇对焦虑和抑郁的不同预测证据

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-13 DOI: 10.1002/dev.22549

Bethany H. McCurdy, Carl F. Weems, Travis Bradley, Ryan Matlow, Victor G. Carrión

{"title":"Evidence of Differential Prediction of Anxiety and Depression by Diurnal Alpha-Amylase and Cortisol in Development","authors":"Bethany H. McCurdy, Carl F. Weems, Travis Bradley, Ryan Matlow, Victor G. Carrión","doi":"10.1002/dev.22549","DOIUrl":"https://doi.org/10.1002/dev.22549","url":null,"abstract":"Research and theory suggest an important role of neuroendocrine function in emotional development, particularly under conditions of elevated stress. We provide empirical data to clarify associations between alpha-amylase (AA) and cortisol as well as test the differential linkages among AA, cortisol, and symptoms of anxiety, depression, and posttraumatic stress in children. Children recruited from a low-income elevated violence community (n = 100; mean age = 10, SD = 0.64; 79% Latino; 67% received free or reduced lunch) were assessed on diurnal levels of AA and cortisol along with assessments of anxiety, depression, and posttraumatic stress symptoms (PTSS). Elevated anxiety symptoms were associated with steeper linear slopes of AA with higher levels of AA in the morning but lower levels of AA in the evening. Depression was associated with differential cubic trajectories of AA when PTSSs were included in the model. Anxiety also predicted differential cubic diurnal trends in cortisol, such that greater anxiety symptoms were associated with relatively higher levels of cortisol in the evening. Again, depression symptoms when PTSS were included predicted diurnal cubic trends with elevated depression associated with lower awakening and midday cortisol that reversed to higher evening cortisol compared to youth with fewer self-reported depression symptoms.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperament in Early Childhood Is Associated With Gut Microbiota Composition and Diversity 幼儿期的性情与肠道微生物群的组成和多样性有关。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-05 DOI: 10.1002/dev.22542

Eriko Ueda, Michiko Matsunaga, Hideaki Fujihara, Takamasa Kajiwara, Aya K. Takeda, Satoshi Watanabe, Keisuke Hagihara, Masako Myowa

{"title":"Temperament in Early Childhood Is Associated With Gut Microbiota Composition and Diversity","authors":"Eriko Ueda, Michiko Matsunaga, Hideaki Fujihara, Takamasa Kajiwara, Aya K. Takeda, Satoshi Watanabe, Keisuke Hagihara, Masako Myowa","doi":"10.1002/dev.22542","DOIUrl":"10.1002/dev.22542","url":null,"abstract":"Temperament is a key predictor of human mental health and cognitive and emotional development. Although human fear behavior is reportedly associated with gut microbiome in infancy, infant gut microbiota changes dramatically during the first 5 years, when the diversity and composition of gut microbiome are established. This period is crucial for the development of the prefrontal cortex, which is involved in emotion regulation. Therefore, this study investigated the relationship between temperament and gut microbiota in 284 preschool children aged 3–4 years. Child temperament was assessed by maternal reports of the Children's Behavior Questionnaire. Gut microbiota (alpha/beta diversity and genera abundance) was evaluated using 16S rRNA sequencing of stool samples. A low abundance of anti-inflammatory bacteria (e.g., Faecalibacterium) and a high abundance of pro-inflammatory bacteria (e.g., Eggerthella, Flavonifractor) were associated with higher negative emotionality and stress response (i.e., negative affectivity, β = −0.17, p = 0.004) and lower positive emotionality and reward-seeking (i.e., surgency/extraversion, β = 0.15, p = 0.013). Additionally, gut microbiota diversity was associated with speed of response initiation (i.e., impulsivity, a specific aspect of surgency/extraversion, β = 0.16, p = 0.008). This study provides insight into the biological mechanisms of temperament and takes important steps toward identifying predictive markers of psychological/emotional risk.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greater Frontoparietal Connectivity During Task Engagement Among Toddlers With Parent-Reported Inattention 家长反映注意力不集中的幼儿在任务参与过程中前额叶连接性更强。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-05 DOI: 10.1002/dev.22546

Heather M. Joseph, Hendrik Santosa, Nadiyah Fisher, Theodore Huppert, Judith K. Morgan

{"title":"Greater Frontoparietal Connectivity During Task Engagement Among Toddlers With Parent-Reported Inattention","authors":"Heather M. Joseph, Hendrik Santosa, Nadiyah Fisher, Theodore Huppert, Judith K. Morgan","doi":"10.1002/dev.22546","DOIUrl":"10.1002/dev.22546","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with lifelong impairments. ADHD-related behaviors have been observed as early as toddlerhood for children who later develop ADHD. Children with ADHD have disrupted connectivity in neural circuitry involved in executive control of attention, including the prefrontal cortex (PFC) and dorsal attention network (DAN). It is not known if these alterations in connectivity can be identified before the onset of ADHD. Children (N = 51) 1.5–3 years old were assessed using functional near-infrared spectroscopy while engaging with a book. The relation between mother-reported ADHD-related behaviors and neural connectivity, computed using robust innovation-based correlation, was examined. Task engagement was high across the sample and unrelated to ADHD-related behaviors. Observed attention was associated with greater connectivity between the right lateral PFC and the right temporal parietal junction (TPJ). Children with greater ADHD-related behaviors had greater frontoparietal connectivity, particularly between the PFC bilaterally and the right TPJ. Toddlers at risk for developing ADHD may require increased frontoparietal connectivity to sustain attention. Future work is needed to examine early interventions that enhance developing attention and their effect on neural connectivity between the PFC and attention networks.\u0000 </section>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0