Developmental psychobiology最新文献_第3页

Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection 脊髓切断后运动和感觉运动反射的发育变化

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-29 DOI: 10.1002/dev.22558

Alleyna C. Martes, Aimee L. Bozeman, Julie Doell, Katie Weedn, Nicholas Collins, Taylor Campbell, Tania L. Roth, Michele R. Brumley

{"title":"Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection","authors":"Alleyna C. Martes, Aimee L. Bozeman, Julie Doell, Katie Weedn, Nicholas Collins, Taylor Campbell, Tania L. Roth, Michele R. Brumley","doi":"10.1002/dev.22558","DOIUrl":"10.1002/dev.22558","url":null,"abstract":"<div>\u0000 \u0000 <p>The developmental trajectory of weight-bearing locomotion and sensorimotor reflexes following a spinal cord injury, as well as the mechanisms for plasticity, remain unclear. In rats, the second postnatal week is a critical period for the development and recovery of spinal sensorimotor function. The purpose of the present study was to characterize developmental changes during this time frame to provide a basis for potential interventions and future research. Rats underwent a complete low-thoracic (T8–T10) spinal cord transection surgery, or sham procedure, on postnatal day (P)1. Spontaneous locomotion and sensorimotor reflexes (surface righting, hindlimb placing, and crossed-extensor reflex) were tested on P7, P14, or P21. Results show that spinal-transected and sham rats exhibited the same amount of spontaneous locomotion, but the degree of relative weight bearing on the hindlimbs was different between groups and changed over time. Reflex findings showed that throughout the neonatal period, the isolated lumbar spinal cord can respond to sensory input and execute coordinated motor output following spinal cord transection. These insights contribute to understanding the developmental trajectory of spinal cord function after injury and provide a foundation for interventions to enhance recovery outcomes.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Alcohol Exposure Disrupts Performance in a Differential Reinforcement of Low Rates Task Specifically in Adolescent Male Rats 产前酒精暴露会干扰青春期雄性大鼠在低速率差异强化任务中的表现。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-28 DOI: 10.1002/dev.22555

Amy E. Perkins, Ellie Dart, Daren Kaiser

{"title":"Prenatal Alcohol Exposure Disrupts Performance in a Differential Reinforcement of Low Rates Task Specifically in Adolescent Male Rats","authors":"Amy E. Perkins, Ellie Dart, Daren Kaiser","doi":"10.1002/dev.22555","DOIUrl":"10.1002/dev.22555","url":null,"abstract":"<p>Prenatal alcohol exposure (PAE) can lead to a wide range of adverse effects in humans, including impaired self-control and increased impulsive behavior. Deficits in self-control can interfere with academic performance and have lasting impacts. In the present study, a rodent model of PAE was used to assess impulsivity through operant conditioning. Pregnant rats were assigned to one of three groups: ad-lib control (CON), pair-fed (PF), and alcohol-exposed (ALC). ALC rats were given a liquid diet containing 6% alcohol, PF rats were yoked to an ALC rat and given a CON liquid diet, and CON rats received ad libitum food. Operant conditioning was used to evaluate extinction in adolescents (Experiment 1) and differential reinforcement of low rates (DRL) in adolescents and adults (Experiment 2). PAE resulted in an increase in responses and resets during DRL testing, indicative of impaired self-control, an effect that was only observed in adolescent males. Females, regardless of age, did not show increased impulsivity following PAE. This indicates that children with PAE may exhibit attentional deficits similar to those with attention deficit hyperactivity disorder, with males at a higher risk.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats 生命早期的稀缺性-超前性对雄性和雌性大鼠成熟期的影响

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-21 DOI: 10.1002/dev.22559

Erin Lauraine, Sasha Oak, Christine H. Nguyen, Millie Rincón-Cortés

{"title":"Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats","authors":"Erin Lauraine, Sasha Oak, Christine H. Nguyen, Millie Rincón-Cortés","doi":"10.1002/dev.22559","DOIUrl":"10.1002/dev.22559","url":null,"abstract":"<div>\u0000 \u0000 <p>Although many studies have shown a long-term negative impact of early life adversity (ELA) in rodents, literature regarding its effects on maturational milestones in rats is scarce. Available evidence suggests that ELA interferes with normal growth and development in rodents and that effects may be sex-dependent even at an early age. In accordance, we hypothesized that early life scarcity-adversity would impair physical and reflex development in male and female rats. To test this, we used an early life resource scarcity paradigm based on reducing home cage bedding during postnatal days (PND) 2–9 and assessed physical landmarks by measuring weight gain, incisor presence, fur development, and eye opening. We also evaluated the impact of early life scarcity-adversity on developmental reflexes by measuring surface righting and grasp reflexes, negative geotaxis, cliff avoidance, bar holding, and auditory startle. Early life scarcity-adversity resulted in earlier complete lower incisor presence in males (PND 6), impaired surface righting (PND 6) and grasp reflexes (PND 8) in both sexes, and impaired cliff avoidance responses in females (PND 12). These results extend previous research examining the effects of ELA on developing male and female rodents by showing that it negatively impacts a subset of physical landmarks and developmental reflexes in a sex-dependent manner.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring Socioeconomic and Stress Disparities in Infant Declarative Memory Using the Visual Paired Comparison Task 利用视觉配对比较任务测量婴儿陈述记忆中的社会经济差异和压力差异

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-17 DOI: 10.1002/dev.22557

Mindy L. Rosengarten, Aislinn Sandre, Sonya V. Troller-Renfree, Lauren C. Shuffrey, Melina Amarante, Marion Bakhoya, Kimberly G. Noble

引用次数: 0

Childhood Maltreatment and Electrodermal Reactivity to Stress Among Pregnant Women 童年虐待与孕妇对压力的电热反应性

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-13 DOI: 10.1002/dev.22553

Bailey Speck, Parisa R. Kaliush, Tracey Tacana, Elisabeth Conradt, Sheila E. Crowell, K. Lee Raby

{"title":"Childhood Maltreatment and Electrodermal Reactivity to Stress Among Pregnant Women","authors":"Bailey Speck, Parisa R. Kaliush, Tracey Tacana, Elisabeth Conradt, Sheila E. Crowell, K. Lee Raby","doi":"10.1002/dev.22553","DOIUrl":"https://doi.org/10.1002/dev.22553","url":null,"abstract":"<p>There are competing theoretical hypotheses regarding the consequences of early adversity, such as childhood maltreatment, for individuals’ autonomic nervous system activity. Research examining potential implications of child maltreatment for sympathetic nervous system activity, specifically, is scarce. In this preregistered study, we examined whether childhood maltreatment history is associated with pregnant adults’ sympathetic responses to different stressors. This population is particularly relevant, given potential intergenerational consequences of pregnant individuals’ physiological responses to stress. Pregnant women's (<i>N</i> = 162) electrodermal levels were recorded while completing the Trier Social Stress Test (TSST), which elicits social-evaluative threat, and while watching a video of an unfamiliar infant crying, which was intended to activate the attachment system. Pregnant women's retrospective reports of childhood maltreatment were negatively associated with their electrodermal reactivity to the TSST and to the video of the infant crying. Follow-up analyses indicated that these associations were specific to reported experiences of childhood abuse and not childhood neglect. Altogether, these findings indicate that self-reported childhood maltreatment experiences, and childhood abuse in particular, may result in blunted activity of the sympathetic nervous system in response to multiple types of stressors.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ganaxolone Therapy After Preterm Birth Restores Cerebellar Oligodendrocyte Maturation and Myelination in Guinea Pigs 早产后服用甘珀酸可恢复几内亚猪小脑少突胶质细胞的成熟和髓鞘化

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-08 DOI: 10.1002/dev.22554

Carlton L. Pavy, Julia C. Shaw, Rebecca M. Dyson, Hannah K. Palliser, Roisin A. Moloney, Ryan P. Sixtus, Mary J. Berry, Jonathan J. Hirst

{"title":"Ganaxolone Therapy After Preterm Birth Restores Cerebellar Oligodendrocyte Maturation and Myelination in Guinea Pigs","authors":"Carlton L. Pavy, Julia C. Shaw, Rebecca M. Dyson, Hannah K. Palliser, Roisin A. Moloney, Ryan P. Sixtus, Mary J. Berry, Jonathan J. Hirst","doi":"10.1002/dev.22554","DOIUrl":"10.1002/dev.22554","url":null,"abstract":"<p>The postnatal environment is challenging for the preterm neonate with exposure to hypoxic and excitotoxic events, amplified by premature loss of placentally derived neurosteroids. Between preterm birth and term equivalent age (TEA), cerebellar development continues despite these challenges. We hypothesize that neurosteroid replacement therapy during this time will support optimal cerebellar development. Guinea pig sows delivered at term (∼69 days gestation) or were induced to deliver preterm (∼62 days), with preterm pups receiving ganaxolone or vehicle until TEA. Postnatal assessments comprised salivary cortisol (corrected postnatal age [CPA] 0, 7, 38), behavioral analysis (CPA7, 38), and tissue collection (CPA0 and CPA40). Neurodevelopmental markers (MBP, Olig2, and NeuN) were assessed in the cerebellum by immunohistochemistry, whereas RT-PCR was utilized to investigate key inhibitory/excitatory pathways and oligodendrocyte lineage markers. Following preterm birth, there was evidence of a hyperactive phenotype, increased salivary cortisol concentrations, and impaired myelination and oligodendrocyte maturation at the protein level. mRNA expressions of key inhibitory/excitatory pathways and myelin stability were also altered following preterm birth. Importantly, we showed that neurosteroid replacement therapy returns cerebellar development and behavior toward a term-like phenotype. Therefore, ganaxolone may reduce the vulnerability of the cerebellum to postnatal challenges arising from preterm birth.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meconium as an Analyte for Androgen Exposure: Analysis Through Varying Maternal-Fetal Biomarkers 作为雄激素暴露分析物的胎粪：通过不同的母胎生物标志物进行分析

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-08 DOI: 10.1002/dev.22550

Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline

{"title":"Meconium as an Analyte for Androgen Exposure: Analysis Through Varying Maternal-Fetal Biomarkers","authors":"Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline","doi":"10.1002/dev.22550","DOIUrl":"10.1002/dev.22550","url":null,"abstract":"<div>\u0000 \u0000 <p>Meconium, the first stool produced by neonates, has been used as an analyte for exogenous fetal exposures. However, few studies have investigated the relationship between meconium and androgen exposure in utero. Here, we examine the associations of testosterone and dehydroepiandrosterone (DHEA) across maternal antenatal salivary testosterone, cord blood, meconium, and infant salivary testosterone. A total of 47 women with singleton, uncomplicated pregnancies, and their infants were included in this study. Participants were recruited from an academic obstetric clinic. Maternal saliva was collected at 36-weeks’ gestation. Cord blood and meconium were collected at birth. Infant salivary testosterone was collected at 1 and 4 weeks of age. Multivariate model results showed that meconium testosterone was associated with neonatal testosterone at 1 (<i>F </i>= 5.62, <i>p </i>= 0.029) and 4 weeks (<i>F </i>= 4.28, <i>p </i>= 0.048) postnatal age; no sex differences were detected. This study suggests meconium is a valuable tool for evaluating endogenous androgen exposure and should be used in future studies to investigate the fetal hormonal milieu.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies 早期逆境对小脑结构和功能的影响--人类和动物研究的系统回顾

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-08 DOI: 10.1002/dev.22556

Annakarina Mundorf, Sarah A. Merklein, Laura C. Rice, John E. Desmond, Jutta Peterburs

{"title":"Early Adversity Affects Cerebellar Structure and Function—A Systematic Review of Human and Animal Studies","authors":"Annakarina Mundorf, Sarah A. Merklein, Laura C. Rice, John E. Desmond, Jutta Peterburs","doi":"10.1002/dev.22556","DOIUrl":"10.1002/dev.22556","url":null,"abstract":"<p>Recent research has highlighted cerebellar involvement in cognition and several psychiatric conditions such as mood and anxiety disorders and schizophrenia. Attention-deficit/hyperactivity disorder and autism spectrum disorder have been linked to reduced cerebellar volume as well. Cerebellar alterations are frequently present after early adversity in humans and animals, but a systematic integration of results is lacking. To this end, a systematic literature search was conducted in PubMed, Web of Science, and EBSCO databases using the keywords “early adversity OR early life stress” AND “cerebellum OR cerebellar.” A total of 45 publications met the inclusion criteria: 25 studies investigated human subjects and 20 reported results from animal models. Findings in healthy subjects show bilateral volume reduction and decreased functional connectivity within the cerebellum and between the cerebellum and frontal regions after adversity throughout life, especially when adversity was assessed with the Childhood Trauma Questionnaire. In clinical populations, adults demonstrate increased cerebellar volume and functional connectivity after adversity, whereas pediatric patients show reduced cerebellar volume. Animal findings reveal cerebellar alterations without necessarily co-occurring pathological behavior, highlighting alterations in stress hormone receptor levels, cell density, and neuroinflammation markers. Cerebellar alterations after early adversity are robust findings across human and animal studies and occur independent of clinical symptoms.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight-Month-Old Infants Are Susceptible to the Auditory Continuity Illusion 八个月大的婴儿易受听觉连续性错觉影响

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-30 DOI: 10.1002/dev.22551

Ryoko Mugitani, Makio Kashino

{"title":"Eight-Month-Old Infants Are Susceptible to the Auditory Continuity Illusion","authors":"Ryoko Mugitani, Makio Kashino","doi":"10.1002/dev.22551","DOIUrl":"10.1002/dev.22551","url":null,"abstract":"<p>The real world is full of noise and constantly overlapping sounds. However, our auditory system provides a solution to this, that is, the continuity illusion; when we hear a sound stream that is partially replaced by high-level noise, we can restore missing sound information and “fill in” the information as if it were smooth and continuous even against a background of noise. In the present study, we tested the preferences for familiar and novel melodies of 8-month-old infants after a 2-month memory retention interval following 1-week exposure to a specific melody. A preference for familiarity was seen not only when the melody was presented intact but also when it was periodically replaced by high-level noise, which elicits the continuity illusion in adults (Experiment 1). However, a trend toward preference for a novel melody was observed for stimuli periodically replaced by low-level noise that did not satisfy the ecological constraints for the elicitation of the illusion (Experiment 2). For the first time, this study showed that infants as young as 8 months of age are susceptible to the auditory continuity illusion. The study also revealed that the infants could recognize the melody they heard 2 months previously.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultural Values Influence the Developmental Trajectory of Resistance to Social Influence Over the Course of Adolescence 文化价值观影响青少年时期抵制社会影响的发展轨迹

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-09-19 DOI: 10.1002/dev.22530

Rui Pei, Elissa Kranzler, Emily B. Falk

引用次数: 0