Developmental psychobiology最新文献

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Is Stress Reactivity an Intermediary Mechanism in the Association Between NR3C1 Methylation and Adolescent Loneliness? 应激反应是NR3C1甲基化与青少年孤独感相关的中介机制吗?
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-08-17 DOI: 10.1002/dev.70190
Yentl Koopmans, Stefanie A. Nelemans, Patricia Bijttebier, Guy Bosmans, Wim Van Den Noortgate, Karla Van Leeuwen, Luc Goossens
{"title":"Is Stress Reactivity an Intermediary Mechanism in the Association Between NR3C1 Methylation and Adolescent Loneliness?","authors":"Yentl Koopmans,&nbsp;Stefanie A. Nelemans,&nbsp;Patricia Bijttebier,&nbsp;Guy Bosmans,&nbsp;Wim Van Den Noortgate,&nbsp;Karla Van Leeuwen,&nbsp;Luc Goossens","doi":"10.1002/dev.70190","DOIUrl":"https://doi.org/10.1002/dev.70190","url":null,"abstract":"<div>\u0000 \u0000 <p>This study examined whether saliva-derived DNA methylation in the glucocorticoid receptor (<i>NR3C1</i>) gene was linked to loneliness through dysregulation of the hypothalamic-pituitary-adrenal axis (HPA-axis) in 101 early adolescents (<i>M</i><sub>age</sub> = 11.61 years, SD<sub>age</sub> = 0.64, 55.45% girls). Using person-centered analyses to account for interindividual differences in adolescents’ stress reactivity, we identified three subgroups of cortisol responders to a social evaluative stressor: A hyporesponsive subgroup (30.5%), a moderate-responsive subgroup (44.2%), and a hyperresponsive subgroup (25.3%). Exploratory analyses also identified subgroups for two markers of the autonomous nervous system (ANS), that is, heart rate (HR) and skin conductance (SC). Furthermore, the indirect effects from <i>NR3C1</i> methylation to early adolescent loneliness via individual differences in stress responses were examined. Results indicated that higher <i>NR3C1</i> methylation levels were associated with a lower probability of belonging to the most reactive stress response subgroups for cortisol and HR, and to the high mean-level subgroup for SC. Additionally, higher probabilities of belonging to the low mean-level SC subgroup were associated with higher levels of loneliness. However, there was no evidence that <i>NR3C1</i> methylation was associated with early adolescent loneliness, either directly or indirectly via stress reactivity. These findings highlight significant individual differences in stress reactivity, emphasizing the need to explicitly consider such variability in future research. Moreover, the results suggest that <i>NR3C1</i> methylation is linked to individual differences in stress responding, warranting further investigation.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal Origins of Stress Regulation: Maternal Psychological Distress and Inflammation During Pregnancy Prospectively Predict Infant Behavioral Reactivity and Regulation 压力调节的产前起源:怀孕期间母亲心理困扰和炎症对婴儿行为反应和调节的前瞻性预测。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-08-16 DOI: 10.1002/dev.70186
Gabrielle R. Rinne, Kharah M. Ross, Christine Dunkel Schetter
{"title":"Prenatal Origins of Stress Regulation: Maternal Psychological Distress and Inflammation During Pregnancy Prospectively Predict Infant Behavioral Reactivity and Regulation","authors":"Gabrielle R. Rinne,&nbsp;Kharah M. Ross,&nbsp;Christine Dunkel Schetter","doi":"10.1002/dev.70186","DOIUrl":"10.1002/dev.70186","url":null,"abstract":"<p>Evolutionary-developmental theories of stress responsivity contend that the in utero environment shapes offspring biobehavioral regulation in a manner that promotes postnatal functioning. To elucidate how the prenatal environment influences stress regulation, this study tested associations of maternal psychological distress and inflammation during pregnancy, based on both levels and changes over time, with infant behavioral stress regulation (<i>n</i> = 118). In early, mid, and late pregnancy, mothers reported on depressive and anxiety symptoms and completed blood draws that were assayed for pro-inflammatory cytokines (IL-6, TNF-⍺). When infants were 1 month old, research staff administered a heel stick blood draw and coded infant behavioral responses. Greater increases in maternal depressive symptoms and IL-6 from early to late pregnancy were associated with greater behavioral reactivity to and recovery from the heel stick. Conversely, higher overall levels of IL-6 predicted lower infant behavioral arousal. Maternal anxiety symptoms during pregnancy did not directly predict infant behavioral regulation, but there was evidence that overall levels of prenatal anxiety predicted infant behavior indirectly via IL-6. Anxiety symptom levels were associated with TNF-⍺. Findings add to evidence on prenatal origins of offspring behavioral regulation and suggest that changes in psychobiological processes over the course of pregnancy may distinctly predict infant outcomes.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental Switch From Elemental to Configural Processing of Odor Mixtures in Humans 人类气味混合处理从元素到结构的发展转变。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-08-05 DOI: 10.1002/dev.70188
Sébastien Romagny, Gérard Coureaud, Thierry Thomas-Danguin
{"title":"Developmental Switch From Elemental to Configural Processing of Odor Mixtures in Humans","authors":"Sébastien Romagny,&nbsp;Gérard Coureaud,&nbsp;Thierry Thomas-Danguin","doi":"10.1002/dev.70188","DOIUrl":"10.1002/dev.70188","url":null,"abstract":"<p>Human perceptual abilities evolve throughout development, particularly with regard to processing complex stimuli. While many studies have investigated age-related changes in olfactory sensitivity, none have examined how developmental stages influence the perception of odor mixtures at the elemental and configural levels. In this study, we evaluated how children, teenagers, and adults (mean ages: 10, 15, and 39 years) perceive odor mixtures known to trigger either elemental or configural processing in adults. Two binary mixtures (AB and AB′) and two senary mixtures (RC and RC′), known to elicit distinct perceptual strategies in adults, were evaluated using three tasks: typicality rating, target detection, and complexity evaluation. Results showed that perception of the senary mixtures remained consistent across age groups, indicating stable processing of these complex mixtures. In contrast, age-related differences emerged for the binary mixtures. Children perceived AB as less complex than AB′, but did not rate it as more typical of the configural odor, whereas adults rated AB as more typical of this odor than AB′ and tended to show reduced access to mixture components in binary mixtures, with teenagers displaying an intermediate profile. Overall, these findings suggest developmental changes in odor mixture processing, consistent with a progressive shift from more elemental to more configural olfactory strategies, particularly for mixtures of lower chemical complexity.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Executive Function and Epigenetic Markers in Youth Exposed to Family and Community Violence in Childhood 儿童期遭受家庭和社区暴力的青少年的执行功能和表观遗传标记。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-08-02 DOI: 10.1002/dev.70183
Renata Queiroz Ramos, Cosme Marcelo Furtado Passos da Silva, Adriane Feijó Evangelista, Fernanda Serpeloni, Natasha Reis Lacerda, Joviana Quintes Avanci, Simone Gonçalves de Assis
{"title":"Executive Function and Epigenetic Markers in Youth Exposed to Family and Community Violence in Childhood","authors":"Renata Queiroz Ramos,&nbsp;Cosme Marcelo Furtado Passos da Silva,&nbsp;Adriane Feijó Evangelista,&nbsp;Fernanda Serpeloni,&nbsp;Natasha Reis Lacerda,&nbsp;Joviana Quintes Avanci,&nbsp;Simone Gonçalves de Assis","doi":"10.1002/dev.70183","DOIUrl":"10.1002/dev.70183","url":null,"abstract":"<p>Although exposure to violence has been linked to executive functioning impairments, the biological mechanisms underlying this association remain unclear. This study examined CpG sites associated with executive functions in 78 young adults and their links to family (psychological and physical) and community violence during childhood. The scales used were Conflict Tactics (family violence); Things I Have Seen and Heard (community violence); Barkley Deficits in Executive Functioning. Mean differences (Mann–Whitney-<i>U</i>/Kruskal–Wallis) and Spearman correlations were assessed. An epigenome-wide association study identified differentially methylated CpGs, and linear regressions examined associations with violence exposures. Girls reported more family and psychological violence. Black participants experienced higher family violence. Executive dysfunction (ED) correlated with psychological family and community violence, and family violence forms were interrelated. Differentially methylated positions highlighted genes tied to key biological processes: <i>MRGPRD</i> (sensory neurons development); <i>DPPA3</i> (germ-cell development); <i>UNKL</i> (cell differentiation); <i>GPR6</i> (learning and memory); <i>DUSP5</i> (cell proliferation and differentiation); and <i>CAPN13</i> (signal transduction, cytoskeletal remodeling and cell differentiation). Candidate gene analysis found associations between executive dysfunction and methylation levels in these genes. Exploratory pathway analysis suggested enrichment of neurodevelopment and synaptic plasticity, intracellular trafficking and cytoskeletal remodeling, genome stability and cellular stress responses, and neuroimmune and inflammatory signaling. These findings suggest associations between ED, childhood violence exposure, and differential DNA methylation in cognition- and health-related genes, suggesting that epigenetic markers may be associated with pathways linking early adversity to later outcomes, although no causal inference can be drawn.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Maternal High-Fat Diet and Neonatal LPS Exposure Prolong USV Sequences and Shift Call-Type Repertoires in Neonatal Rats” 更正“母体高脂肪饮食和新生儿LPS暴露延长了新生大鼠的USV序列并改变了呼叫型曲目”。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-08-02 DOI: 10.1002/dev.70181
{"title":"Correction to “Maternal High-Fat Diet and Neonatal LPS Exposure Prolong USV Sequences and Shift Call-Type Repertoires in Neonatal Rats”","authors":"","doi":"10.1002/dev.70181","DOIUrl":"10.1002/dev.70181","url":null,"abstract":"<p>Purohit MK, Woo I, Rahman M, Abuaish S, McGowan PO. Maternal High-Fat Diet and Neonatal LPS Exposure Prolong USV Sequences and Shift Call-Type Repertoires in Neonatal Rats. Dev Psychobiol. 2026 Mar;68(2):e70142. https://doi.org/10.1002/dev.70142.</p><p>In the original version:</p><p>Figure 5 was a duplicate of Figure 4. The correct Figure 5 appears below.</p><p>The reference citation for Rahman and McGowan (2022) was incorrect. The correct reference is:</p><p>Rahman, M. F., Yuksel, C. B., and McGowan, P. O. 2022. “Combined Exposure to Maternal High-Fat Diet and Neonatal Lipopolysaccharide Disrupts Stress-Related Signaling but Normalizes Spatial Memory in Juvenile Rats.” <i>Brain, Behavior, and Immunity</i> 102: 299–311. https://doi.org/10.1016/j.bbi.2022.03.003</p><p>Figures 1, 2, 6, and 7 were published in low resolution. The high-resolution figures appear below.</p><p>We apologize for the error.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infants' Sleep Supports the Emergence and Mastery of Locomotor and Linguistic Skills 婴儿睡眠支持运动和语言技能的出现和掌握
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-07-29 DOI: 10.1002/dev.70187
Mali Waugh, Sarah E. Berger
{"title":"Infants' Sleep Supports the Emergence and Mastery of Locomotor and Linguistic Skills","authors":"Mali Waugh,&nbsp;Sarah E. Berger","doi":"10.1002/dev.70187","DOIUrl":"https://doi.org/10.1002/dev.70187","url":null,"abstract":"<div>\u0000 \u0000 <p>Infant sleep is disrupted around the onset of motor milestones, but the causal mechanisms underlying this relationship are unclear. This study aims to corroborate prior reports of the link between locomotor milestone onset and sleep disruptions and expand the literature by asking whether language milestones are also associated with sleep disruptions. Time-series changepoint detection analyzed parent reported milestone onset data and sleep data of two age cohorts collected remotely through an online app and baby monitor system. Disruptions to sleep were found relative to the onsets of first crawling steps, first walking steps, walking mastery, babbling, cooing, expressive jargon, new word use, and object labeling. These results replicate evidence for a relationship between sleep disruption and locomotor milestone onset and offer the first evidence of disruptions to sleep associated with language milestones. To our knowledge this is the first study to show that skill acquisition affects infants’ sleep prior to the expression of the skill. Changes in sleep patterns demonstrate that prior to skill onset skill-relevant behaviors are marshaled and coordinated to facilitate the emergence of new skills. After skill onset, sleep functions to consolidate new knowledge and skills and support the process of mastery.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Methods for Prenatal Cannabis Exposure: Vapor Inhalation Chamber and Metabolite Quantification in Prairie Voles and Rats 产前大麻暴露的创新方法:草原田鼠和大鼠的蒸汽吸入室和代谢物定量。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-07-24 DOI: 10.1002/dev.70185
Sophia Rogers, Casey E. Hogrefe, Chun-Yi Wu, Adele M. H. Seelke, Anurupa Kar, Sabrina L. Mederos, Jessica Bond, Felisa J. Carbajal, Zhenmo Yu, Melissa D. Bauman, Karen L. Bales
{"title":"Innovative Methods for Prenatal Cannabis Exposure: Vapor Inhalation Chamber and Metabolite Quantification in Prairie Voles and Rats","authors":"Sophia Rogers,&nbsp;Casey E. Hogrefe,&nbsp;Chun-Yi Wu,&nbsp;Adele M. H. Seelke,&nbsp;Anurupa Kar,&nbsp;Sabrina L. Mederos,&nbsp;Jessica Bond,&nbsp;Felisa J. Carbajal,&nbsp;Zhenmo Yu,&nbsp;Melissa D. Bauman,&nbsp;Karen L. Bales","doi":"10.1002/dev.70185","DOIUrl":"10.1002/dev.70185","url":null,"abstract":"<p>The increasing prevalence of cannabis use, including among pregnant women, highlights the critical need for a deeper understanding of prenatal cannabis exposure. This study aimed to develop a standardized cross-species inhalation exposure protocol to administer the principal psychoactive component of cannabis, Δ9-tetrahydrocannabinol (THC), to prairie voles (<i>Microtus ochrogaster</i>) and laboratory rats (<i>Rattus norvegicus</i>), and to investigate the distribution of THC in maternal and fetal tissues following prenatal exposure. Using an established e-cigarette system for delivering vaporized THC, we administered THC to pregnant prairie voles and rats. THC concentrations were measured in maternal plasma and fetal brain tissue using LC–MS/MS (liquid chromatography coupled with tandem mass spectrometry). We found that THC readily crossed the placental barrier in both species, resulting in significantly higher concentrations of THC in the fetal brain within the THC-exposed groups compared to the vehicle controls. Interspecies comparison revealed higher THC concentrations in rat fetal brain tissue compared to prairie voles. No significant effects of fetal position on THC levels were found for either species. The findings confirm placental transfer of THC and reveal species-specific patterns of THC distribution. Additional studies were then carried out in voles to compare plasma and brain THC levels in maternal and virgin adult prairie voles. Maternal brain THC concentrations were significantly higher than fetal brain concentrations in prairie voles. This study establishes a translational model for investigating prenatal cannabis exposure using an aerosolized administration method in voles compared to established methods in rats. The standardized protocol and results provide a foundation for future research into the developmental consequences of prenatal cannabis exposure and offer crucial insights for informing public health policies and clinical practices in response to the global increase in cannabis use.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13397050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Omega-3 Fatty Acid Docosahexaenoic Acid Supplementation in Individuals During Pregnancy on Neurodevelopment and Growth of Offspring: Systematic Review and Meta-Analysis 孕期补充Omega-3脂肪酸二十二碳六烯酸对后代神经发育和生长的影响:系统回顾和荟萃分析。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-07-24 DOI: 10.1002/dev.70184
Linyun Xie, Meicen Zhou, Liqun Lu, XueMei Ning, Yue Song
{"title":"Impact of Omega-3 Fatty Acid Docosahexaenoic Acid Supplementation in Individuals During Pregnancy on Neurodevelopment and Growth of Offspring: Systematic Review and Meta-Analysis","authors":"Linyun Xie,&nbsp;Meicen Zhou,&nbsp;Liqun Lu,&nbsp;XueMei Ning,&nbsp;Yue Song","doi":"10.1002/dev.70184","DOIUrl":"10.1002/dev.70184","url":null,"abstract":"<div>\u0000 \u0000 <p>Maternal prenatal docosahexaenoic acid (DHA) intake is critical for fetal brain and retinal development; however, evidence regarding its effects on offspring neurodevelopment and growth remains inconsistent. This systematic review and meta-analysis evaluated the efficacy of prenatal DHA supplementation on offspring neurodevelopmental outcomes (attention, motor, intelligence, language, executive function, and short-term memory) and growth parameters (birth weight, head circumference, gestational age, and birth length) in the general population. We analyzed randomized controlled trials (RCTs) from 2001 to 2023 across PubMed, Embase, and the Cochrane Library. Of 917 records, 21 RCTs were included in the systematic review, of which 19 were eligible for meta-analysis. The meta-analysis showed that prenatal DHA supplementation had no significant benefits on any neurodevelopmental outcome. Subgroup analyses revealed no improvements across all assessed domains (all <i>p</i> &gt; 0.05). In contrast, prenatal DHA supplementation significantly increased neonatal birth weight (mean difference [MD] = 72.51 g, 95% CI: 37.55–107.48), whereas no notable improvements were observed in head circumference, gestational age, birth length, or any of the assessed neurodevelopmental outcomes. Overall, the current evidence does not support benefits of prenatal DHA supplementation for neurodevelopmental outcomes or for growth outcomes other than birth weight in the general population. Future research should focus on identifying subgroups that may be responsive to DHA based on genetic, nutritional, or environmental factors.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low Pregnancy Cortisol and Infant Socioemotional Problems: The Mediating Role of Postpartum Depressive Symptoms 低妊娠皮质醇与婴儿社会情绪问题:产后抑郁症状的中介作用
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-07-03 DOI: 10.1002/dev.70180
Jennifer E. Khoury, Lauren Giles, Mackenna Pattison, Tanya Tulipan, Victoria Allen, Marsha Campbell-Yeo, Tara Perrot
{"title":"Low Pregnancy Cortisol and Infant Socioemotional Problems: The Mediating Role of Postpartum Depressive Symptoms","authors":"Jennifer E. Khoury,&nbsp;Lauren Giles,&nbsp;Mackenna Pattison,&nbsp;Tanya Tulipan,&nbsp;Victoria Allen,&nbsp;Marsha Campbell-Yeo,&nbsp;Tara Perrot","doi":"10.1002/dev.70180","DOIUrl":"10.1002/dev.70180","url":null,"abstract":"<p>Infant socioemotional development has important implications for later functioning, reflecting capacities for emotional regulation, stress responsivity, and social engagement. Stress and mental health during pregnancy and the postpartum can adversely influence infant socioemotional functioning. This study examined whether postpartum depressive and anxiety symptoms mediate associations between prenatal maternal hair cortisol concentration (HCC) and infant socioemotional development. A sample of 128 participants was followed from the third trimester of pregnancy to 6 months postpartum. Maternal HCC was collected during the third trimester to reflect cortisol during the second half of pregnancy. Symptoms of depression and anxiety were measured at 2 weeks postpartum, and infant socioemotional problems were assessed at 6 months of age. Structural equation modeling tested postpartum depression and anxiety as parallel mediators. Results indicated that lower HCC in pregnancy predicted greater postpartum depression (<i>B</i> = −3.676, <i>p</i> = 0.003) and anxiety (<i>B</i> = −3.41, <i>p</i> = 0.009); depression was associated with greater infant socioemotional problems at 6 months (<i>B</i> = 1.900, <i>p</i> &lt; 0.001). HCC was not directly associated with infant socioemotional outcomes (<i>B</i> = 1.071, <i>p</i> = 0.792); however, the indirect effect, through depressive symptoms, was significant (<i>B</i> = −6.99, <i>p</i> = 0.01). These findings suggest that prenatal physiological stress may influence infant socioemotional development indirectly through early postpartum depressive symptoms, highlighting the importance of integrated perinatal processes.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bedding Type Modulates the Effects of Postpartum Resource Scarcity on Maternal Behavior in Rats 床褥类型调节产后资源稀缺对母性行为的影响。
IF 1.9 4区 心理学
Developmental psychobiology Pub Date : 2026-07-02 DOI: 10.1002/dev.70182
Jeffy Jackson, Christine H. Nguyen, Skylar Mendez, Erin Lauraine, Jasmine Peter, Millie Rincón-Cortés
{"title":"Bedding Type Modulates the Effects of Postpartum Resource Scarcity on Maternal Behavior in Rats","authors":"Jeffy Jackson,&nbsp;Christine H. Nguyen,&nbsp;Skylar Mendez,&nbsp;Erin Lauraine,&nbsp;Jasmine Peter,&nbsp;Millie Rincón-Cortés","doi":"10.1002/dev.70182","DOIUrl":"10.1002/dev.70182","url":null,"abstract":"<div>\u0000 \u0000 <p>Resource scarcity paradigms are widely used to model environmentally induced disruptions in rodent maternal behavior. Yet, the critical methodological variable of bedding substrate type has received limited attention despite substantial variation in its use across laboratories. This study examined how two distinct bedding types (corncob, cellulose) interact with scarcity-adversity to influence maternal behavior in postpartum rats. We report that scarcity-adversity reliably increased insensitive pup-directed behaviors, elevated stress-related behaviors (tail biting/chasing), and impaired pup retrieval performance across both bedding types, confirming that resource scarcity disrupts maternal care regardless of substrate. However, the specific pattern of behavioral effects differed across bedding conditions. Increases in pup shoving were specific to scarcity-adversity dams in corncob bedding, whereas increases in anogenital licking of pups were specific to scarcity-adversity dams in cellulose bedding. Independent of adversity, cellulose dams displayed greater percentages of time spent grooming pups and nest building, while corncob dams displayed greater percentages of time spent nursing. In the pup retrieval test, cellulose dams exhibited longer latencies to retrieve 70% of pups than corncob dams. Together, these findings suggest that while core scarcity-adversity effects on insensitive pup-directed behaviors and pup retrieval generalize across these two substrates, bedding properties shape the specific expression of maternal behavioral disruption. Cellulose bedding may partially buffer certain aspects of intended adversity through compensatory caregiving, while corncob bedding may compound adversity through substrate discomfort. We recommend reporting bedding type in resource scarcity studies to facilitate cross-laboratory comparisons and ensure substrate characteristics align with experimental goals when modeling postpartum environmental adversity.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"68 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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