Developmental psychobiology最新文献_第4页

Trajectories of Maternal Behavior, Infant's Respiratory Sinus Arrhythmia, and Emotional Recovery Following the Still Face Paradigm 母亲行为轨迹、婴儿呼吸窦性心律失常与静脸范式后情绪恢复。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-12-08 DOI: 10.1002/dev.70011

Lindsey M. Green, Stephanie F. Thompson, Lisa Shimomaeda, Lynn Fainsilber Katz, Liliana J. Lengua

{"title":"Trajectories of Maternal Behavior, Infant's Respiratory Sinus Arrhythmia, and Emotional Recovery Following the Still Face Paradigm","authors":"Lindsey M. Green, Stephanie F. Thompson, Lisa Shimomaeda, Lynn Fainsilber Katz, Liliana J. Lengua","doi":"10.1002/dev.70011","DOIUrl":"10.1002/dev.70011","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of emotion regulation is integral to children's socioemotional adjustment. Respiratory sinus arrhythmia (RSA) reflects parasympathetic regulation of cardiac arousal and is thought to be an indicator of emotion regulation. However, it is unclear how RSA is associated with positive maternal behaviors and infant emotional recovery in real time over the course of a recovery period following a social stressor. Mothers and their 5- to 6-month-old infants (<i>N</i> = 143) completed the Still Face paradigm. Using a series of autoregressive latent trajectory models, the current study aimed to elucidate the associations among observed maternal warmth, infant RSA, and observed infant negative affect across a 5-min observation. The hypotheses were that trajectories of maternal warmth would predict trajectories of infant RSA and negative affect, and that trajectories of RSA would be associated with the infants' observed negative affect. Change in maternal warmth was associated with infant negative affect and RSA at the end of the reunion and change in RSA was associated with ultimate levels of negative affect. The results provide partial support for our hypothesis that maternal warmth supports infant physiological, and in turn, emotional recovery.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Sensitization in Virgin Female Rats: Behavioral Effects of Enriched Environment 母性致敏的处女雌性大鼠：富集环境的行为影响。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-12-08 DOI: 10.1002/dev.70010

Mauricio A. Núñez-Murrieta, Esmeralda Rendón-Candanedo, Diana Angeles-Torres, Paula Noguez, Genaro A. Coria-Avila, Victoria E. Bolado-García, Aleph A. Corona-Morales

{"title":"Maternal Sensitization in Virgin Female Rats: Behavioral Effects of Enriched Environment","authors":"Mauricio A. Núñez-Murrieta, Esmeralda Rendón-Candanedo, Diana Angeles-Torres, Paula Noguez, Genaro A. Coria-Avila, Victoria E. Bolado-García, Aleph A. Corona-Morales","doi":"10.1002/dev.70010","DOIUrl":"10.1002/dev.70010","url":null,"abstract":"<div>\u0000 \u0000 <p>In virgin female rats, the continuous presence of pups causes them to express typical maternal behaviors, a process known as maternal sensitization. Previous experience with pups accelerates maternal sensitization. It is also known that in primiparous rats, enriched environment (EE) increases the expression of maternal behaviors. Here, we investigated whether experience, other than pup exposure, affects the process of maternal sensitization and hypothesized that EE increases the expression of maternal behaviors and maternal motivation in virgin rats. Virgin adult females were housed in standard conditions or physical and social EE for 21 days. Then, females were exposed daily to pups until they expressed full maternal behaviors. Thereafter, females performed pup preference, pup motivation in a novel context, and resident-intruder tests. We found that initial pup rejection was higher in EE rats, but eventually, both groups became maternally sensitized simultaneously. The frequency and duration of pup licking were higher in EE rats. In the other tests, EE rats exhibited more entries to the open arms, retrieved more pups toward the closed arms, and were more aggressive towards an intruder. We conclude that housing in a social EE modulates aspects of the pup-induced maternal sensitization, particularly increasing pup licking and motivation in both familiar and novel circumstances.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Effects of Prenatal Buprenorphine and Methadone on Postnatal Growth and Gene Expression in the Nucleus Accumbens 产前丁丙诺啡和美沙酮对出生后伏隔核生长和基因表达的差异影响。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-12-08 DOI: 10.1002/dev.70015

Kelsea R. Gildawie, Kerri E. Budge, Fair M. Vassoler, Elizabeth Yen, Elizabeth M. Byrnes

{"title":"Differential Effects of Prenatal Buprenorphine and Methadone on Postnatal Growth and Gene Expression in the Nucleus Accumbens","authors":"Kelsea R. Gildawie, Kerri E. Budge, Fair M. Vassoler, Elizabeth Yen, Elizabeth M. Byrnes","doi":"10.1002/dev.70015","DOIUrl":"10.1002/dev.70015","url":null,"abstract":"<div>\u0000 \u0000 <p>Methadone and buprenorphine are commonly prescribed during pregnancy to maintain recovery and prevent symptoms of withdrawal in women with opioid use disorder. Infants prenatally exposed to medications for opioid use disorder (MOUD), however, commonly show signs of neonatal opioid withdrawal syndrome (NOWS), which can include feeding-related issues like hyperphagia. To investigate the effects of prenatal MOUD exposure on feeding behavior, female Sprague-Dawley rats were implanted with osmotic minipumps filled with methadone, buprenorphine, or saline and subsequently mated. On postnatal day (PND) 1, buprenorphine- and methadone-exposed offspring weighed less than saline-exposed subjects. Throughout early postnatal development (PND2, 7, and 12), this reduction in weight persisted in buprenorphine, but not methadone, offspring. RNAscope in situ hybridization was then used to measure expression of genes in the nucleus accumbens (NAc) previously associated with hyperphagia in NOWS infants, including proopiomelanocortin (<i>Pomc</i>), neuropeptide Y2 receptors (<i>Npy2r</i>), and dopamine type 2 receptors (<i>Drd2</i>). Distinct developmental expression patterns were noted across the postnatal period, with few effects of MOUD; however, significantly lower <i>Pomc</i> expression was observed in methadone-exposed but not buprenorphine-exposed offspring. These findings demonstrate differential effects of methadone and buprenorphine on offspring development and gene expression, highlighting differences in offspring outcomes associated with these two MOUDs.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross-Species Systematic Review 母体产前应激与子代肠道微生物组：跨物种系统综述。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-12-05 DOI: 10.1002/dev.70005

Michelle D. Graf, Nicolas Murgueitio, Sarah C. Vogel, Lauren Hicks, Alexander L. Carlson, Cathi B. Propper, Mary Kimmel

{"title":"Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross-Species Systematic Review","authors":"Michelle D. Graf, Nicolas Murgueitio, Sarah C. Vogel, Lauren Hicks, Alexander L. Carlson, Cathi B. Propper, Mary Kimmel","doi":"10.1002/dev.70005","DOIUrl":"10.1002/dev.70005","url":null,"abstract":"<div>\u0000 \u0000 <p>The prenatal period is a critical developmental juncture with enduring effects on offspring health trajectories. An individual's gut microbiome is associated with health and developmental outcomes across the lifespan. Prenatal stress can disrupt an infant's microbiome, thereby increasing susceptibility to adverse outcomes. This cross-species systematic review investigates whether maternal prenatal stress affects the offspring's gut microbiome. The study analyzes 19 empirical, peer-reviewed research articles, including humans, rodents, and non-human primates, that included prenatal stress as a primary independent variable and offspring gut microbiome characteristics as an outcome variable. Prenatal stress appeared to correlate with differences in beta diversity and specific microbial taxa, but not alpha diversity. Prenatal stress is positively correlated with Proteobacteria, Bacteroidaceae, Lachnospiraceae, Prevotellaceae, <i>Bacteroides</i>, and <i>Serratia</i>. Negative correlations were observed for Actinobacteria, Enterobacteriaceae, Streptococcaceae, <i>Bifidobacteria, Eggerthella, Parabacteroides</i>, and <i>Streptococcus</i>. Evidence for the direction of association between prenatal stress and <i>Lactobacillus</i> was mixed. The synthesis of findings was limited by differences in study design, operationalization and timing of prenatal stress, timing of infant microbiome sampling, and microbiome analysis methods.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Prenatal, Perinatal, and Postnatal Factors and ADHD: The Role of Nutrition, Diet, and Stress 产前、围产期和产后因素与多动症之间的关系：营养、饮食和压力的作用。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-11-07 DOI: 10.1002/dev.70004

Lubna Al-Gailani, Ali Al-Kaleel

{"title":"The Relationship Between Prenatal, Perinatal, and Postnatal Factors and ADHD: The Role of Nutrition, Diet, and Stress","authors":"Lubna Al-Gailani, Ali Al-Kaleel","doi":"10.1002/dev.70004","DOIUrl":"10.1002/dev.70004","url":null,"abstract":"<div>\u0000 \u0000 <p>Attention-Deficit Hyperactive Disorder (ADHD) is a neurobehavioral syndrome affecting children aged 6–17 with symptoms manifesting before age 12. ADHD presents heterogeneously and is associated with various psychiatric disorders. The cause remains elusive, but genetic and environmental factors, brain region maturation delays, and neurotransmitter dysregulation are implicated. Effective treatment requires a multi-disciplinary approach, primarily involving pharmacological and behavioral intervention. Stimulants like methylphenidate and amphetamines are first-line medications, but non-stimulants may be considered for some patients. However, stimulants face challenges related to misuse, dependence, and long-term tolerability issues. The etiology of ADHD involved genetic predisposition, environmental influences, and prenatal, perinatal, and postnatal factors. Prenatal causes encompass maternal diet, alcohol consumption, viral infections, and stress. Postnatal factors include head trauma, meningitis, toxin, nutritional deficiencies, as well as iodine deficiency and hypothyroidism. The gut microbiome's role in ADHD is emerging, influencing neurodevelopment through microbiota–gut–brain axis. Understanding these diverse etiological factors is essential for comprehensive ADHD management.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Zika Virus Exposure Alters the Interaction Between Affective Processing and Decision-Making in Juvenile Rhesus Macaques (Macaca mulatta) 产前接触寨卡病毒会改变幼年猕猴情感处理与决策之间的相互作用

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-11-07 DOI: 10.1002/dev.70002

Patrick R. Cogo, Gilda Moadab, Eliza Bliss-Moreau, Florent Pittet

{"title":"Prenatal Zika Virus Exposure Alters the Interaction Between Affective Processing and Decision-Making in Juvenile Rhesus Macaques (Macaca mulatta)","authors":"Patrick R. Cogo, Gilda Moadab, Eliza Bliss-Moreau, Florent Pittet","doi":"10.1002/dev.70002","DOIUrl":"10.1002/dev.70002","url":null,"abstract":"<div>\u0000 \u0000 <p>Many challenges during pregnancy can disrupt fetal development and have varying consequences on the subsequent psychological development of infants. Notably, exposure to infectious pathogens during fetal development, such as those encountered in viral pandemics, has been associated with persistent developmental consequences on infants’ brains and behavior. However, the underlying mechanisms and the degree to which neural plasticity over infancy may accommodate fetal insults remain unclear. To address this gap, we investigated the interaction between affective processing and decision-making in a cohort of rhesus monkey juveniles exposed to Zika virus (ZIKV) during fetal development, a pathogen known to profoundly disrupt central nervous system development. Ten juveniles exposed to ZIKV during their fetal development and nine procedure-matched controls (CONs) completed a judgment bias task with and without a negative mood induction. Although ZIKV exposure did not impact the monkeys’ decision-making processes during the task or the magnitude of their behavioral responses to the mood induction procedure, it did alter the influence of mood induction on decision-making. Although CON monkeys exhibited significantly more conservative decision-making following negative mood induction, the decision-making of Zika-exposed monkeys remained consistent among conditions. These findings suggest that fetal exposure to ZIKV impacts the neural systems involved in integrating affective and cognitive information, with potential long-term implications for learning, memory, and emotion regulation.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early- and Late-Stage Auditory Processing of Speech Versus Non-Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study 自闭症谱系障碍儿童早期和晚期对语音和非语音声音的听觉处理：ERP和振荡活动研究》。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-11-07 DOI: 10.1002/dev.22552

Elizabeth V. Edgar, Kjersti McGuire, Kevin A. Pelphrey, Pamela Ventola, Stefon van Noordt, Michael J. Crowley

{"title":"Early- and Late-Stage Auditory Processing of Speech Versus Non-Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study","authors":"Elizabeth V. Edgar, Kjersti McGuire, Kevin A. Pelphrey, Pamela Ventola, Stefon van Noordt, Michael J. Crowley","doi":"10.1002/dev.22552","DOIUrl":"10.1002/dev.22552","url":null,"abstract":"<div>\u0000 \u0000 <p>Individuals with autism spectrum disorder (ASD) often exhibit greater sensitivity to non-speech sounds, reduced sensitivity to speech, and increased variability in cortical activity during auditory speech processing. We assessed differences in cortical responses and variability in early and later processing stages of auditory speech versus non-speech sounds in typically developing (TD) children and children with ASD. Twenty-eight 4- to 9-year-old children (14 ASDs) listened to speech and non-speech sounds during an electroencephalography session. We measured peak amplitudes for early (P2) and later (P3a) stages of auditory processing and inter-trial theta phase coherence as a marker of cortical variability. TD children were more sensitive to speech sounds during early and later processing stages than ASD children, reflected in larger P2 and P3a amplitudes. Individually, twice as many TD children showed reliable differentiation between speech and non-speech sounds compared to children with ASD. Children with ASD showed greater intra-individual variability in theta responses to speech sounds during early and later processing stages. Children with ASD show atypical auditory processing of fundamental speech sounds, perhaps due to reduced and more variable cortical activation. These atypicalities in the consistency of cortical responses to fundamental speech features may impact the development of cortical networks and have downstream effects on more complex forms of language processing.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences Between Preterm and Full-Term Infants in Electroencephalogram Power Spectral Density Slope 早产儿和足月儿脑电图功率谱密度斜率的差异。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-11-05 DOI: 10.1002/dev.70001

Jennifer Hammond, Rakesh Sahni, Philip Grieve, Joseph Isler, Elizabeth Werner, Brendan Ostlund, Daniel Alschuler, Seonjoo Lee, Catherine Monk

{"title":"Differences Between Preterm and Full-Term Infants in Electroencephalogram Power Spectral Density Slope","authors":"Jennifer Hammond, Rakesh Sahni, Philip Grieve, Joseph Isler, Elizabeth Werner, Brendan Ostlund, Daniel Alschuler, Seonjoo Lee, Catherine Monk","doi":"10.1002/dev.70001","DOIUrl":"10.1002/dev.70001","url":null,"abstract":"<div>\u0000 \u0000 <p>A growing body of literature suggests that power spectral density (PSD) slope, measured using electroencephalography (EEG), might reflect synaptic activity and be a useful marker of early brain development. The objective of this article is to identify differences between preterm and full-term infants in PSD slope in active and quiet sleep. This is a secondary analysis of two studies, including premature (<i>N</i> = 33) (30 0/7 and 36 0/7 weeks’ gestation) and full-term infants (<i>N</i> = 22). EEG was performed at near term-equivalent age in premature infants and within 36 h after birth in full-term infants. The natural log of the EEG power spectrum was plotted versus the natural log of the frequency spectrum. To estimate PSD slope, the power law exponent derived from the slope of the log(power) versus log(frequency) was calculated for the 1–20 Hz range and the 21–40 Hz range. Linear regression models were fit for each region in active and quiet sleep to examine the association between the PSD slope and infant age group. Preterm versus full-term infants demonstrated a less negative slope across multiple brain regions in active and quiet sleep. PSD slope may be an early measure of altered brain development in premature infants.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Supraspinal Influences on Human Embryonic Posture 早期脊柱上部对人类胚胎姿势的影响

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-29 DOI: 10.1002/dev.70000

Sophie Plasschaert, Annemarie Mulders, Anne Frudiger, Anton Koning, Regine Steegers-Theunissen, Johanna de Vries, Eric Steegers, Melek Rousian

{"title":"Early Supraspinal Influences on Human Embryonic Posture","authors":"Sophie Plasschaert, Annemarie Mulders, Anne Frudiger, Anton Koning, Regine Steegers-Theunissen, Johanna de Vries, Eric Steegers, Melek Rousian","doi":"10.1002/dev.70000","DOIUrl":"10.1002/dev.70000","url":null,"abstract":"<p>Knowledge of embryonic body posture as a reflection of neurodevelopment is limited. Here, we investigate embryonic body posture, preference, symmetry, and lateralization during periods of rest using virtual reality (VR) and four-dimensional (4D) ultrasound techniques to enhance our knowledge of neurodevelopment. It is hypothesized that lateralization and asymmetry in embryonic posture are absent. Embryos from low-risk pregnancies at 9 weeks gestational age (GA) were analyzed using a 30-min 4D ultrasound and VR techniques. In the middle of an embryonic resting period, the total body posture was determined by combining joint positions. Interindividual and intraindividual postures were analyzed over time to identify posture preferences, asymmetry, and lateralization. Sixteen embryos (<i>N</i> = 210 middle frames out of 210 resting periods) displayed 27 different embryonic body postures. Interindividual and intraindividual variations in postures were seen. Asymmetry was noted in upper extremities, whereas lateralization of the head and spine was observed in nine embryos. Intraindividual and interindividual variation in embryonic posture at 9 weeks’ GA is seen, suggesting the presence of supraspinal influences on body posture this early. Future interdisciplinary longitudinal studies on embryonic posture may provide further insights into embryonic central nervous system development, contributing to our understanding of embryonic health.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection 脊髓切断后运动和感觉运动反射的发育变化

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-10-29 DOI: 10.1002/dev.22558

Alleyna C. Martes, Aimee L. Bozeman, Julie Doell, Katie Weedn, Nicholas Collins, Taylor Campbell, Tania L. Roth, Michele R. Brumley

{"title":"Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection","authors":"Alleyna C. Martes, Aimee L. Bozeman, Julie Doell, Katie Weedn, Nicholas Collins, Taylor Campbell, Tania L. Roth, Michele R. Brumley","doi":"10.1002/dev.22558","DOIUrl":"10.1002/dev.22558","url":null,"abstract":"<div>\u0000 \u0000 <p>The developmental trajectory of weight-bearing locomotion and sensorimotor reflexes following a spinal cord injury, as well as the mechanisms for plasticity, remain unclear. In rats, the second postnatal week is a critical period for the development and recovery of spinal sensorimotor function. The purpose of the present study was to characterize developmental changes during this time frame to provide a basis for potential interventions and future research. Rats underwent a complete low-thoracic (T8–T10) spinal cord transection surgery, or sham procedure, on postnatal day (P)1. Spontaneous locomotion and sensorimotor reflexes (surface righting, hindlimb placing, and crossed-extensor reflex) were tested on P7, P14, or P21. Results show that spinal-transected and sham rats exhibited the same amount of spontaneous locomotion, but the degree of relative weight bearing on the hindlimbs was different between groups and changed over time. Reflex findings showed that throughout the neonatal period, the isolated lumbar spinal cord can respond to sensory input and execute coordinated motor output following spinal cord transection. These insights contribute to understanding the developmental trajectory of spinal cord function after injury and provide a foundation for interventions to enhance recovery outcomes.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0