Developmental psychobiology最新文献_第4页

Adult Offspring of Deer Mouse Breeding Pairs Selected for Normal and Compulsive-Like Large Nesting Expression Invariably Show the Same Behavior Without Prior In-Breeding 因正常和强迫性大筑巢表现而被选中的鹿鼠繁殖配对的成年后代在没有事先近亲繁殖的情况下总是表现出相同的行为。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-08-06 DOI: 10.1002/dev.22533

Heike Stoppel, Brian H. Harvey, De Wet Wolmarans

{"title":"Adult Offspring of Deer Mouse Breeding Pairs Selected for Normal and Compulsive-Like Large Nesting Expression Invariably Show the Same Behavior Without Prior In-Breeding","authors":"Heike Stoppel, Brian H. Harvey, De Wet Wolmarans","doi":"10.1002/dev.22533","DOIUrl":"10.1002/dev.22533","url":null,"abstract":"<p>Obsessive-compulsive disorder is a neuropsychiatric condition with notable genetic involvement. Against this background, laboratory-housed deer mice of both sexes varyingly present with excessive and persistent large nesting behavior (LNB), which has been validated for its resemblance of clinical compulsivity. Although LNB differs from normal nesting behavior (NNB) on both a biological and cognitive level, it is unknown to what extent the expression of LNB and NNB is related to familial background. Here, we randomly selected 14 NNB- and 14 LNB-expressing mice (equally distributed between sexes) to constitute 7 breeding pairs of each phenotype. Pairs were allowed to breed two successive generations of offspring, which were raised until adulthood (12 weeks) and assessed for nesting expression. Remarkably, our findings show that offspring from LNB-expressing pairs build significantly larger nests compared to offspring from NNB-expressing pairs and the nesting expression of the offspring of each breeding pair, irrespective of parental phenotype or litter, is family specific. Collectively, the results of this investigation indicate that LNB can be explored for its potential to shed light on heritable neurocognitive mechanisms that may underlie the expression of specific persistent behavioral phenotypes.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substance Use and Its Relationship With Attachment and Early Maladaptive Schemes in Adolescents in Ecuador 厄瓜多尔青少年的药物使用及其与依恋和早期适应不良模式的关系。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-08-06 DOI: 10.1002/dev.22532

Leticia Olave, Janire Momeñe, Laura Macía, Patricia Macía, María Dolores Chávez-Vera, Marta Herrero, Ana Estévez, Itziar Iruarrizaga

{"title":"Substance Use and Its Relationship With Attachment and Early Maladaptive Schemes in Adolescents in Ecuador","authors":"Leticia Olave, Janire Momeñe, Laura Macía, Patricia Macía, María Dolores Chávez-Vera, Marta Herrero, Ana Estévez, Itziar Iruarrizaga","doi":"10.1002/dev.22532","DOIUrl":"10.1002/dev.22532","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Given the scarcity of studies addressing substance consumption and its relationship with attachment styles and early maladaptive schemas in adolescents, the present study is proposed. Aims of this study are to analyze the relationship among attachment styles, early maladaptive schemas, and substance use; test the predictive role of attachment styles on substance use; and observe the mediating role of early maladaptive schemas in the relationship between attachment and substance use. The sample consisted of 1533 adolescents from Ecuador (53.9% males) aged between 14 and 18 years (<i>M</i> = 15.76; SD = 1.25). The attachment styles of security, value to parental authority, parental permissiveness, parental interference, self-sufficiency and resentment against parents, childhood trauma, and family concern predict substance use (tobacco, alcohol, tranquilizers/sedatives or sleeping pills, hashish or marijuana, cocaine, GHB or liquid ecstasy, ecstasy, amphetamines/speed, hallucinogens, heroin, inhalants/volatiles), and the mediating role of early maladaptive schemas is confirmed (explained variance up to 33.33%). Identifying risk or vulnerability factors, such as attachment and early maladaptive schemas related to substance consumption, is especially relevant for designing and implementing preventive interventions in the adolescent population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caregivers’ Attention Toward, and Response to, Their Child's Interoceptive Hunger and Thirst Cues 看护人对孩子饥饿和口渴内感知线索的关注和反应。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-22 DOI: 10.1002/dev.22531

Richard J. Stevenson, Jonathan Serebro, Alexandra Mruk, Daiana Martin-Rivera, Shirley Wyver, Heather M. Francis

{"title":"Caregivers’ Attention Toward, and Response to, Their Child's Interoceptive Hunger and Thirst Cues","authors":"Richard J. Stevenson, Jonathan Serebro, Alexandra Mruk, Daiana Martin-Rivera, Shirley Wyver, Heather M. Francis","doi":"10.1002/dev.22531","DOIUrl":"10.1002/dev.22531","url":null,"abstract":"<p>People can use their internal state to determine if they are hungry or thirsty. Although the meaning of some interoceptive cues may be innate (e.g., pain), it is possible that others—including those for hunger and thirst—are acquired. There has been little exploration of this idea in humans. Consequently, we conducted a survey among child caregivers to determine if the basic conditions necessary for interoceptive learning were present. Two-hundred and thirty-five caregivers of children aged 1–12 years were asked if they had recently noticed stomach rumbling, hunger-related irritability, and a dry mouth in their child. They were also asked how they would respond. The impact of several moderating variables, especially caregiver beliefs about the causes of hunger, fullness, and thirst, was also explored. Fifteen percent of caregivers had recently noticed stomach rumbling in their child, 28% hunger-related irritability, and 14% a dry mouth. Forty-four percent of caregivers had noticed at least one of these three cues. Noticing hunger cues was significantly moderated by caregiver beliefs about their cause, by child age, and in one case by temporal context (around vs. outside mealtimes). Key caregiver responses were providing the need (e.g., offer food) and/or asking the child if they had a need (e.g., hungry?). Each type of response could potentially support a different form of interoceptive learning. In conclusion, we suggest the necessary conditions for children to learn interoceptive hunger and thirst cues, are present in many caregiver–offspring dyads.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsic Infant Hippocampal Function Supports Inhibitory Processing 婴儿海马固有功能支持抑制性处理

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-15 DOI: 10.1002/dev.22529

Anika Guha, Sharon K. Hunter, Kristina T. Legget, Maureen McHugo, M. Camille Hoffman, Jason R. Tregellas

{"title":"Intrinsic Infant Hippocampal Function Supports Inhibitory Processing","authors":"Anika Guha, Sharon K. Hunter, Kristina T. Legget, Maureen McHugo, M. Camille Hoffman, Jason R. Tregellas","doi":"10.1002/dev.22529","DOIUrl":"10.1002/dev.22529","url":null,"abstract":"<div>\u0000 \u0000 <p>Impaired cerebral inhibition is commonly observed in neurodevelopmental disorders and may represent a vulnerability factor for their development. The hippocampus plays a key role in inhibition among adults and undergoes significant and rapid changes during early brain development. Therefore, the structure represents an important candidate region for early identification of pathology that is relevant to inhibitory dysfunction. To determine whether hippocampal function corresponds to inhibition in the early postnatal period, the present study evaluated relationships between hippocampal activity and sensory gating in infants 4–20 weeks of age (<i>N</i> = 18). Resting-state functional magnetic resonance imaging was used to measure hippocampal activity, including the amplitude of low-frequency fluctuations (ALFFs) and fractional ALFF. Electroencephalography during a paired-stimulus paradigm was used to measure sensory gating (P50). Higher activity of the right hippocampus was associated with better sensory gating (P50 ratio), driven by a reduction in response to the second stimulus. These findings suggest that meaningful effects of hippocampal function can be detected early in infancy. Specifically, higher intrinsic hippocampal activity in the early postnatal period may support effective inhibitory processing. Future work will benefit from longitudinal analysis to clarify the trajectory of hippocampal function, alterations of which may contribute to the risk of neurodevelopmental disorders and represent an intervention target.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Prone Skills and Motor-Based Problem-Solving Abilities in Full-Term and Preterm Infants During the First 6 Months of Life 出生后 6 个月内足月儿和早产儿的俯卧技能与运动解决问题能力之间的关系。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-10 DOI: 10.1002/dev.22525

Ketaki Inamdar, Tanya Tripathi, Rebecca M. Molinini, Wei Fang, Arya Salgaonkar, Stacey C. Dusing

{"title":"Relationship Between Prone Skills and Motor-Based Problem-Solving Abilities in Full-Term and Preterm Infants During the First 6 Months of Life","authors":"Ketaki Inamdar, Tanya Tripathi, Rebecca M. Molinini, Wei Fang, Arya Salgaonkar, Stacey C. Dusing","doi":"10.1002/dev.22525","DOIUrl":"10.1002/dev.22525","url":null,"abstract":"<p>Motor experiences shape cognitive development in infancy, with the prone position being one such crucial motor experience in the first 6 months of life. Although the motor benefits of the prone position are well-documented, its influence on early cognitive abilities remains insufficiently explored. This study quantified the relationship between prone motor skills and motor-based problem-solving abilities in 48 full-term and preterm infants aged 3–6 months. Prone skills were assessed using the Alberta Infant Motor Scale's prone domain. The Assessment of Problem-Solving in Play was utilized to measure motor-based problem-solving by observing how motor actions were used to solve toys. Advanced prone motor skills were correlated with an increase in sophisticated exploration skills and a concurrent decline in lower order exploration skills in all infants, with correlations being stronger in preterm infants. Notably, a 1-point increase in prone skills was associated with a 1.3-point increase in total motor-based problem-solving abilities in all infants. Our findings provide preliminary evidence for the contribution of prone play to cognitive development in infants, prompting considerations for assessment and intervention strategies. Further research is needed to ascertain if the delayed acquisition of prone motor skills is indicative of poor early problem-solving abilities in preterm infants.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Nobody Here Likes Her”—The Impact of Parental Verbal Threat Information on Children's Fear of Strangers "这里没人喜欢她"--父母的口头威胁信息对儿童害怕陌生人的影响。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-09 DOI: 10.1002/dev.22526

Cosima A. Nimphy, Bernet M. Elzinga, Willem Van der Does, Bram Van Bockstaele, Koraly Pérez-Edgar, Michiel Westenberg, Evin Aktar

{"title":"“Nobody Here Likes Her”—The Impact of Parental Verbal Threat Information on Children's Fear of Strangers","authors":"Cosima A. Nimphy, Bernet M. Elzinga, Willem Van der Does, Bram Van Bockstaele, Koraly Pérez-Edgar, Michiel Westenberg, Evin Aktar","doi":"10.1002/dev.22526","DOIUrl":"10.1002/dev.22526","url":null,"abstract":"<p>Parental verbal threat (vs. safety) information about strangers may induce fears of these strangers in adolescents. In this multi-method experimental study, utilizing a within-subject design, parents provided standardized verbal threat or safety information to their offspring (<i>N</i> = 77, <i>M<sub>age</sub></i> = 11.62 years, 42 girls) regarding two strangers in the lab. We also explored whether the impact of parental verbal threat information differs depending on the social anxiety levels of parents or fearful temperaments of adolescents. Adolescent's fear of strangers during social interaction tasks was assessed using cognitive (fear beliefs, attention bias), behavioral (observed avoidance and anxiety), and physiological (heart rate) indices. We also explored whether the impact of parental verbal threat information differs depending on the social anxiety levels of parents or fearful temperaments of adolescents. The findings suggest that a single exposure to parental verbal threat (vs. safety) information increased adolescent's self-reported fears about the strangers but did not increase their fearful behaviors, heart rate, or attentional bias. Furthermore, adolescents of parents with higher social anxiety levels or adolescents with fearful temperaments were not more strongly impacted by parental verbal threat information. Longitudinal research and studies investigating parents’ naturalistic verbal expressions of threat are needed to expand our understanding of this potential verbal fear-learning pathway.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reaching While Learning to Sit: Capturing the Kinematics of Co-Developing Skills at Home 边学坐边伸手：捕捉在家共同发展技能的运动学。

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-07 DOI: 10.1002/dev.22527

Jana M. Iverson, Emily R. Britsch, Joshua L. Schneider, Samantha N. Plate, Valentina Focaroli, Fabrizio Taffoni, Flavio Keller

{"title":"Reaching While Learning to Sit: Capturing the Kinematics of Co-Developing Skills at Home","authors":"Jana M. Iverson, Emily R. Britsch, Joshua L. Schneider, Samantha N. Plate, Valentina Focaroli, Fabrizio Taffoni, Flavio Keller","doi":"10.1002/dev.22527","DOIUrl":"10.1002/dev.22527","url":null,"abstract":"<div>\u0000 \u0000 <p>This study examined the co-development of infant reaching and postural control across the transition to arms-free sitting at home. We observed infants with typical likelihood (TL; <i>n</i> = 24) and elevated likelihood (EL; <i>n</i> = 20) for autism at four biweekly sessions spanning the transition to arms-free sitting (infant age = 4.5–8 months at first session). At each session, infants sat on a pressure-sensitive mat with external support or independently, wore magneto-inertial sensors on both wrists, and reached for toys presented at midline. Analyses focused on characterizing and comparing control of sitting during reaching actions and standard kinematic metrics of reaching during Supported versus Independent Sitting. Although EL infants achieved arms-free sitting later than TL peers, there were no group differences on any measures. Across sessions, infants’ control of the sitting posture during concurrent reaching movements improved in both contexts, though they were less stable as they reached when sitting independently compared to when sitting with support. A similar effect was apparent in the kinematics of reaches, with overall improvement over time, but evidence of poorer control in Independent relative to Supported Sitting. Taken together, these findings underscore the mutually influential and dynamic relations between emerging skills and well-established behaviors.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and Age Differences in Ontogeny of Alloparenting: A Relation to Forebrain DRD1, DRD2, and HTR2A mRNA Expression? 异体亲子关系本体发育的性别和年龄差异：与前脑 DRD1、DRD2 和 HTR2A mRNA 表达的关系？

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-07 DOI: 10.1002/dev.22524

Yujie Huang, Ruoting Qing, Yu Yang, Ming Li, Jun Gao

{"title":"Sex and Age Differences in Ontogeny of Alloparenting: A Relation to Forebrain DRD1, DRD2, and HTR2A mRNA Expression?","authors":"Yujie Huang, Ruoting Qing, Yu Yang, Ming Li, Jun Gao","doi":"10.1002/dev.22524","DOIUrl":"10.1002/dev.22524","url":null,"abstract":"<div>\u0000 \u0000 <p>Alloparenting refers to the practice of caring for the young by individuals other than their biological parents. The relationship between the dynamic changes in psychological functions underlying alloparenting and the development of specific neuroreceptors remains unclear. Using a classic 10-day pup sensitization procedure, together with a pup preference and pup retrieval test on the EPM (elevated plus maze), we showed that both male and female adolescent rats (24 days old) had significantly shorter latency than adult rats (65 days old) to be alloparental, and their motivation levels for pups and objects were also significantly higher. In contrast, adult rats retrieved more pups than adolescent rats even though they appeared to be more anxious on the EPM. Analysis of mRNA expression using real-time-PCR revealed a higher dopamine D<sub>2</sub> receptor (DRD2) receptor expression in adult hippocampus, amygdala, and ventral striatum, along with higher dopamine D<sub>1</sub> receptor (DRD1) receptor expression in ventral striatum compared to adolescent rats. Adult rats also showed significantly higher levels of 5-hydroxytryptamine receptor 2A (HTR2A) receptor expression in the medial prefrontal cortex, amygdala, ventral striatum, and hypothalamus. These results suggest that the faster onset of alloparenting in adolescent rats compared to adult rats, along with the psychological functions involved, may be mediated by varying levels of dopamine DRD1, DRD2, and HTR2A in different forebrain regions.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupillary Responses to Dynamic Negative Versus Positive Facial Expressions of Emotion in Children and Parents: Links to Depression and Anxiety 瞳孔对儿童和父母面部动态消极与积极情绪表达的反应：与抑郁和焦虑的联系

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-05 DOI: 10.1002/dev.22522

Evin Aktar, Marianna Venetikidi, Bram van Bockstaele, Danielle van der Giessen, Koraly Pérez-Edgar

{"title":"Pupillary Responses to Dynamic Negative Versus Positive Facial Expressions of Emotion in Children and Parents: Links to Depression and Anxiety","authors":"Evin Aktar, Marianna Venetikidi, Bram van Bockstaele, Danielle van der Giessen, Koraly Pérez-Edgar","doi":"10.1002/dev.22522","DOIUrl":"10.1002/dev.22522","url":null,"abstract":"<p>Witnessing emotional expressions in others triggers physiological arousal in humans. The current study focused on pupil responses to emotional expressions in a community sample as a physiological index of arousal and attention. We explored the associations between parents’ and offspring's responses to dynamic facial expressions of emotion, as well as the links between pupil responses and anxiety/depression. Children (<i>N</i> = 90, <i>M<sub>Age</sub></i> = 10.13, range = 7.21–12.94, 47 girls) participated in this lab study with one of their parents (47 mothers). Pupil responses were assessed in a computer task with dynamic happy, angry, fearful, and sad expressions, while participants verbally labeled the emotion displayed on the screen as quickly as possible. Parents and children reported anxiety and depression symptoms in questionnaires. Both parents and children showed stronger pupillary responses to negative versus positive expressions, and children's responses were overall stronger than those of parents. We also found links between the pupil responses of parents and children to negative, especially to angry faces. Child pupil responses were related to their own and their parents’ anxiety levels and to their parents’ (but not their own) depression. We conclude that child pupils are sensitive to individual differences in parents’ pupils and emotional dispositions in community samples.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22522","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Stress Affects the Relaxin/Insulin-Like Family Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats 急性应激影响青春期雄性 Wistar 大鼠脑中松弛素/类胰岛素家族肽受体 3 mRNA 的表达

IF 1.8 4区心理学

Developmental psychobiology Pub Date : 2024-07-05 DOI: 10.1002/dev.22523

Miłosz Gołyszny, Michał Zieliński, Ewa Obuchowicz

{"title":"Acute Stress Affects the Relaxin/Insulin-Like Family Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats","authors":"Miłosz Gołyszny, Michał Zieliński, Ewa Obuchowicz","doi":"10.1002/dev.22523","DOIUrl":"10.1002/dev.22523","url":null,"abstract":"<div>\u0000 \u0000 <p>The current literature suggests that relaxin-3/relaxin/insulin-like family peptide receptor 3 (RLN-3/RXFP-3) system is involved in the pathophysiology of affective disorders because the results of anatomical and pharmacological studies have shown that the RLN-3 signaling pathway plays a role in modulating the stress response, anxiety, arousal, depression-like behavior, and neuroendocrine homeostasis. The risk of developing mental illnesses in adulthood is increased by exposure to stress in early periods of life. The available data indicate that puberty is especially characterized by the development of the neural system and emotionality and is a “stress-sensitive” period. The presented study assessed the short-term changes in the expression of RLN-3 and RXFP-3 mRNA in the stress-dependent brain regions in male pubertal Wistar rats that had been subjected to acute stress. Three stressors were applied from 42 to 44 postnatal days (first day: a single forced swim; second day: stress on an elevated platform that was repeated three times; third day: restraint stress three times). Anxiety (open field, elevated plus maze test) and anhedonic-like behavior (sucrose preference test) were estimated during these tests. The corticosterone (CORT) levels and blood morphology were estimated. We found that the RXFP-3 mRNA expression decreased in the brainstem, whereas it increased in the hypothalamus 72 h after acute stress. These molecular changes were accompanied by the increased levels of CORT and anxiety-like behavior detected in the open field test that had been conducted earlier, that is, 24 h after the stress procedure. These findings shed new light on the neurochemical changes that are involved in the compensatory response to adverse events in pubertal male rats and support other data that suggest a regulatory interplay between the RLN-3 pathway and the hypothalamus–pituitary–adrenal axis activity in the mechanisms of anxiety-like behavior.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0