产前接触寨卡病毒会改变幼年猕猴情感处理与决策之间的相互作用

IF 1.8 4区 心理学 Q3 DEVELOPMENTAL BIOLOGY
Patrick R. Cogo, Gilda Moadab, Eliza Bliss-Moreau, Florent Pittet
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引用次数: 0

摘要

怀孕期间的许多挑战都会扰乱胎儿的发育,并对婴儿随后的心理发育产生不同的影响。值得注意的是,在胎儿发育期间接触传染性病原体(如病毒大流行时遇到的病原体)与婴儿大脑和行为的持续发育后果有关。然而,婴儿期神经可塑性适应胎儿损伤的潜在机制和程度仍不清楚。为了填补这一空白,我们研究了一组在胎儿发育期间暴露于寨卡病毒(ZIKV)的恒河猴幼猴的情感处理和决策之间的相互作用。十只在胎儿发育期间接触过 ZIKV 病毒的幼猴和九只程序匹配对照组(CONs)分别在有和没有负面情绪诱导的情况下完成了一项判断偏差任务。虽然暴露于ZIKV病毒不会影响猴子在任务中的决策过程,也不会影响它们对情绪诱导程序的行为反应程度,但它确实改变了情绪诱导对决策的影响。虽然CON猴在消极情绪诱导后表现出明显更保守的决策,但寨卡暴露猴的决策在不同条件下保持一致。这些研究结果表明,胎儿暴露于寨卡病毒会影响参与整合情感和认知信息的神经系统,从而对学习、记忆和情绪调节产生潜在的长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prenatal Zika Virus Exposure Alters the Interaction Between Affective Processing and Decision-Making in Juvenile Rhesus Macaques (Macaca mulatta)

Many challenges during pregnancy can disrupt fetal development and have varying consequences on the subsequent psychological development of infants. Notably, exposure to infectious pathogens during fetal development, such as those encountered in viral pandemics, has been associated with persistent developmental consequences on infants’ brains and behavior. However, the underlying mechanisms and the degree to which neural plasticity over infancy may accommodate fetal insults remain unclear. To address this gap, we investigated the interaction between affective processing and decision-making in a cohort of rhesus monkey juveniles exposed to Zika virus (ZIKV) during fetal development, a pathogen known to profoundly disrupt central nervous system development. Ten juveniles exposed to ZIKV during their fetal development and nine procedure-matched controls (CONs) completed a judgment bias task with and without a negative mood induction. Although ZIKV exposure did not impact the monkeys’ decision-making processes during the task or the magnitude of their behavioral responses to the mood induction procedure, it did alter the influence of mood induction on decision-making. Although CON monkeys exhibited significantly more conservative decision-making following negative mood induction, the decision-making of Zika-exposed monkeys remained consistent among conditions. These findings suggest that fetal exposure to ZIKV impacts the neural systems involved in integrating affective and cognitive information, with potential long-term implications for learning, memory, and emotion regulation.

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来源期刊
Developmental psychobiology
Developmental psychobiology 生物-发育生物学
CiteScore
4.20
自引率
18.20%
发文量
125
审稿时长
6-12 weeks
期刊介绍: Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.
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