Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection

IF 1.8 4区心理学 Q3 DEVELOPMENTAL BIOLOGY

Developmental psychobiology Pub Date : 2024-10-29 DOI:10.1002/dev.22558

Alleyna C. Martes, Aimee L. Bozeman, Julie Doell, Katie Weedn, Nicholas Collins, Taylor Campbell, Tania L. Roth, Michele R. Brumley

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Abstract

The developmental trajectory of weight-bearing locomotion and sensorimotor reflexes following a spinal cord injury, as well as the mechanisms for plasticity, remain unclear. In rats, the second postnatal week is a critical period for the development and recovery of spinal sensorimotor function. The purpose of the present study was to characterize developmental changes during this time frame to provide a basis for potential interventions and future research. Rats underwent a complete low-thoracic (T8–T10) spinal cord transection surgery, or sham procedure, on postnatal day (P)1. Spontaneous locomotion and sensorimotor reflexes (surface righting, hindlimb placing, and crossed-extensor reflex) were tested on P7, P14, or P21. Results show that spinal-transected and sham rats exhibited the same amount of spontaneous locomotion, but the degree of relative weight bearing on the hindlimbs was different between groups and changed over time. Reflex findings showed that throughout the neonatal period, the isolated lumbar spinal cord can respond to sensory input and execute coordinated motor output following spinal cord transection. These insights contribute to understanding the developmental trajectory of spinal cord function after injury and provide a foundation for interventions to enhance recovery outcomes.

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脊髓切断后运动和感觉运动反射的发育变化

脊髓损伤后负重运动和感觉运动反射的发育轨迹以及可塑性机制仍不清楚。在大鼠中，出生后第二周是脊髓感觉运动功能发育和恢复的关键时期。本研究的目的是描述这一时期的发育变化，为潜在的干预措施和未来的研究提供依据。大鼠在出生后第 1 天接受了低胸（T8-T10）脊髓完全横断手术或假手术。在出生后第7天、第14天或第21天测试大鼠的自发运动和感觉运动反射（体表扶正、后肢放置和交叉伸肌反射）。结果表明，脊髓横断大鼠和假大鼠表现出相同的自发运动量，但后肢相对负重的程度在不同组间有所不同，并且随着时间的推移而变化。反射研究结果表明，在整个新生儿期，脊髓横断后，离体腰脊髓可以对感觉输入做出反应，并执行协调的运动输出。这些发现有助于了解脊髓损伤后的功能发育轨迹，并为采取干预措施提高康复效果奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental psychobiology 生物-发育生物学

CiteScore

4.20

自引率

18.20%

发文量

125

审稿时长

6-12 weeks

期刊介绍： Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.