Developmental psychobiology最新文献_第10页

Comparative analysis of electrodermal activity metrics and their association with child behavior in autism spectrum disorder 对比分析自闭症谱系障碍的皮电活动指标及其与儿童行为的关系

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22461

Jessica L. Greenlee, Emily Lorang, Robert H. Olson, Geovanna Rodriquez, Dasoo Milton Yoon, Sigan Hartley

{"title":"Comparative analysis of electrodermal activity metrics and their association with child behavior in autism spectrum disorder","authors":"Jessica L. Greenlee, Emily Lorang, Robert H. Olson, Geovanna Rodriquez, Dasoo Milton Yoon, Sigan Hartley","doi":"10.1002/dev.22461","DOIUrl":"10.1002/dev.22461","url":null,"abstract":"Researchers are increasingly utilizing physiological data like electrodermal activity (EDA) to understand how stress “gets under the skin.” Results of EDA studies in autistic children are mixed, with some suggesting autistic hyperarousal, others finding hypoarousal, and yet others detecting no difference compared to non-autistics. Some of this variability likely stems from the different techniques used to assess EDA. Therefore, the purpose of this study is to investigate and compare commonly used metrics of EDA (frequency of peaks, average amplitude of peaks, and standard deviation of skin conductance level) using two data processing programs (NeuroKit2 and Ledalab) and their link to observed child behavior. EDA data were collected using Empatica E4 wristbands from 60 autistic children and adolescents (5–18 years old) during a 7-min play interaction with their primary caregiver. The play interaction was coded for a range of child behaviors including mood, social responsiveness, dysregulation, and cooperation. Results indicate a strong correlation between NeuroKit2 and Ledalab and a weak correlation between metrics within each program. Furthermore, the frequency of peaks was associated with more positive child social behaviors, and the magnitude of peaks was associated with less adaptive child behaviors. Recommendations for replication and the need for generalizability of this research are given.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the biological impacts of parent–child relationship dynamics on preschool-aged children who have experienced adversity 研究亲子关系动态对经历逆境的学龄前儿童的生物学影响

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22463

Jesse L. Coe, Teresa Daniels, Lindsay Huffhines, Ronald Seifer, Carmen J. Marsit, Hung-Teh Kao, Barbara Porton, Stephanie H. Parade, Audrey R. Tyrka

{"title":"Examining the biological impacts of parent–child relationship dynamics on preschool-aged children who have experienced adversity","authors":"Jesse L. Coe, Teresa Daniels, Lindsay Huffhines, Ronald Seifer, Carmen J. Marsit, Hung-Teh Kao, Barbara Porton, Stephanie H. Parade, Audrey R. Tyrka","doi":"10.1002/dev.22463","DOIUrl":"10.1002/dev.22463","url":null,"abstract":"Parent–child relationship dynamics have been shown to predict socioemotional and behavioral outcomes for children, but little is known about how they may affect biological development. The aim of this study was to test if observational assessments of parent–child relationship dynamics (cohesion, enmeshment, and disengagement) were associated with three biological indices of early life adversity and downstream health risk: (1) methylation of the glucocorticoid receptor gene (NR3C1), (2) telomere attrition, and (3) mitochondrial biogenesis, indexed by mitochondrial deoxyribonucleic acid (DNA) copy number (mtDNAcn), all of which were measured in children's saliva. We tested hypotheses using a sample of 254 preschool-aged children (M age = 51.04 months) with and without child welfare-substantiated maltreatment (52% with documented case of moderate-severe maltreatment) who were racially and ethnically diverse (17% Black, 40% White, 23% biracial, and 20% other races; 45% Hispanic) and from primarily low-income backgrounds (91% qualified for public assistance). Results of path analyses revealed that: (1) higher parent–child cohesion was associated with lower levels of methylation of NR3C1 exon 1D and longer telomeres, and (2) higher parent–child disengagement was associated with higher levels of methylation of NR3C1 exon 1D and shorter telomeres. Results suggest that parent–child relationship dynamics may have distinct biological effects on children.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139590202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy 母亲的童年逆境与婴儿的表观遗传衰老：孕期睡眠不安的调节作用

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22464

David W. Sosnowski, Darlynn M. Rojo-Wissar, Gang Peng, Stephanie H. Parade, Katherine Sharkey, Cathrine Hoyo, Susan K. Murphy, Raquel G. Hernandez, Sara B. Johnson

{"title":"Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy","authors":"David W. Sosnowski, Darlynn M. Rojo-Wissar, Gang Peng, Stephanie H. Parade, Katherine Sharkey, Cathrine Hoyo, Susan K. Murphy, Raquel G. Hernandez, Sara B. Johnson","doi":"10.1002/dev.22464","DOIUrl":"10.1002/dev.22464","url":null,"abstract":"Maternal exposure to childhood adversity is associated with detrimental health outcomes throughout the life span and may have implications for offspring. Evidence links maternal adverse childhood experiences (ACEs) to detrimental birth outcomes, yet the impact on the infant's epigenome is unclear. Moreover, maternal sleep habits during pregnancy may influence this association. Here, we explore whether restless sleep during pregnancy moderates the association between exposure to maternal childhood adversity and infant epigenetic age acceleration in 332 mother–infant dyads (56% female; 39% Black; 25% Hispanic). During the second trimester, mothers self-reported childhood adversity and past-week restless sleep; DNA methylation from umbilical vein endothelial cells was used to estimate five epigenetic clocks. Multivariable linear regression was used to test study hypotheses. Despite no evidence of main effects, there was evidence of an interaction between maternal ACEs and restless sleep in predicting infant epigenetic age acceleration using the EPIC gestational age clock. Only infants whose mothers reported exposure to both ACEs and restless sleep demonstrated accelerated epigenetic aging. Results provide preliminary evidence that maternal childhood adversity and sleep may influence the infant epigenome.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits 质量而非数量青少年游戏经验不足会导致内侧前额叶皮层神经元改变和社会认知技能缺陷

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-21 DOI: 10.1002/dev.22456

Jackson R. Ham, Madeline Szabo, Jessica Annor-Bediako, Rachel A. Stark, Andrew N. Iwaniuk, Sergio M. Pellis

{"title":"Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits","authors":"Jackson R. Ham, Madeline Szabo, Jessica Annor-Bediako, Rachel A. Stark, Andrew N. Iwaniuk, Sergio M. Pellis","doi":"10.1002/dev.22456","DOIUrl":"10.1002/dev.22456","url":null,"abstract":"Reduced play experience over the juvenile period leads to adults with impoverished social skills and to anatomical and physiological aberrations of the neurons found in the medial prefrontal cortex (mPFC). Even rearing rats from high-playing strains with low-playing strains show these developmental consequences. In the present study, we evaluated whether low-playing rats benefit from being reared with higher playing peers. To test this, we reared male Fischer 344 rats (F344), typically thought to be a low-playing strain, with a Long–Evans (LE) peer, a relatively high-playing strain. As juveniles, F344 rats reared with LE rats experienced less play and lower quality play compared to those reared with another F344. As adults, the F344 rats reared with LE partners exhibited poorer social skills and the pyramidal neurons of their mPFC had larger dendritic arbors than F344 rats reared with same-strain peers. These findings show that being reared with a more playful partner does not improve developmental outcomes of F344 rats, rather the discordance in the play styles of F344 and LE rats leads to poorer outcomes.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139516252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience of discrimination reported during pregnancy and infant's emerging effortful control 怀孕期间遭受歧视的经历与婴儿新出现的努力控制能力

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-17 DOI: 10.1002/dev.22455

Kenia M. Rivera, Kimberly L. D'Anna-Hernandez, Benjamin L. Hankin, Elysia Poggi Davis, Jenalee R. Doom

{"title":"Experience of discrimination reported during pregnancy and infant's emerging effortful control","authors":"Kenia M. Rivera, Kimberly L. D'Anna-Hernandez, Benjamin L. Hankin, Elysia Poggi Davis, Jenalee R. Doom","doi":"10.1002/dev.22455","DOIUrl":"https://doi.org/10.1002/dev.22455","url":null,"abstract":"Discrimination reported during pregnancy is associated with poorer offspring emotional outcomes. Links with effortful control have yet to be examined. This study investigated whether pregnant individuals’ reports of lifetime racial/ethnic discrimination and everyday discrimination (including but not specific to race/ethnicity) reported during pregnancy were associated with offspring emerging effortful control at 6 months of age. Pregnant individuals (N = 174) and their offspring (93 female infants) participated. During pregnancy, participants completed two discrimination measures: (1) lifetime experience of racial/ethnic discrimination, and (2) everyday discrimination (not specific to race/ethnicity). Parents completed the Infant Behavior Questionnaire—Revised when infants were 6 months old to assess orienting/regulation, a measure of emerging effortful control. Analyses were conducted in a subsample with racially/ethnically marginalized participants and then everyday discrimination analyses were repeated in the full sample. For racially/ethnically marginalized participants, greater everyday discrimination (β = −.27, p = .01) but not greater lifetime experience of racial/ethnic discrimination (β = −.21, p = .06) was associated with poorer infant emerging effortful control. In the full sample, greater everyday discrimination was associated with poorer infant emerging effortful control (β = −.24, p = .002). Greater perceived stress, but not depressive symptoms, at 2 months postnatal mediated the association between everyday discrimination and emerging effortful control. Further research should examine additional biological and behavioral mechanisms by which discrimination reported during pregnancy may affect offspring emerging effortful control.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139488371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental windows for effects of choline and folate on excitatory and inhibitory neurotransmission during human gestation 胆碱和叶酸对人类妊娠期兴奋性和抑制性神经传递影响的发育窗口

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-09 DOI: 10.1002/dev.22453

Sharon K. Hunter, M. Camille Hoffman, Angelo D'Alessandro, Robert Freedman

{"title":"Developmental windows for effects of choline and folate on excitatory and inhibitory neurotransmission during human gestation","authors":"Sharon K. Hunter, M. Camille Hoffman, Angelo D'Alessandro, Robert Freedman","doi":"10.1002/dev.22453","DOIUrl":"https://doi.org/10.1002/dev.22453","url":null,"abstract":"Choline and folate are critical nutrients for fetal brain development, but the timing of their influence during gestation has not been previously characterized. At different periods during gestation, choline stimulation of α7-nicotinic receptors facilitates the conversion of γ-aminobutyric acid (GABA) receptors from excitatory to inhibitory and recruitment of GluR1-R2 receptors for faster excitatory responses to glutamate. The outcome of the fetal development of inhibition and excitation was assessed in 159 newborns by P50 cerebral auditory-evoked responses. Paired stimuli, S1 and S2, were presented 500 ms apart. Higher P50 amplitude in response to S1 (P50S1microV) assesses excitation, and lower P50S2microV assesses inhibition in this paired-stimulus paradigm. The development of inhibition was related solely to maternal choline plasma concentration and folate supplementation at 16 weeks’ gestation. The development of excitation was related only to maternal choline at 28 weeks. Higher maternal choline concentrations later in gestation did not compensate for earlier lower concentrations. At 4 years of age, increased behavior problems on the Child Behavior Checklist 1.5–5 years were related to both newborn inhibition and excitation. The incomplete development of inhibition and excitation associated with lower choline and folate during relatively brief periods of gestation thus has enduring effects on child development.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139406827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal oxytocin treatment at birth increases epigenetic age in male offspring 出生时母体催产素会增加男性后代的表观遗传年龄

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-04 DOI: 10.1002/dev.22452

Joshua S. Danoff, C. Sue Carter, Juozas Gordevičius, Milda Milčiūtė, Robert T. Brooke, Jessica J. Connelly, Allison M. Perkeybile

{"title":"Maternal oxytocin treatment at birth increases epigenetic age in male offspring","authors":"Joshua S. Danoff, C. Sue Carter, Juozas Gordevičius, Milda Milčiūtė, Robert T. Brooke, Jessica J. Connelly, Allison M. Perkeybile","doi":"10.1002/dev.22452","DOIUrl":"https://doi.org/10.1002/dev.22452","url":null,"abstract":"Exogenous oxytocin is widely used to induce or augment labor with little understanding of the impact on offspring development. In rodent models, including the prairie vole (Microtus ochrogaster), it has been shown that oxytocin administered to mothers can affect the nervous system of the offspring with long-lasting behavioral effects especially on sociality. Here, we examined the hypothesis that perinatal oxytocin exposure could have epigenetic and transcriptomic consequences. Prairie voles were exposed to exogenous oxytocin, through injections given to the mother just prior to birth, and were studied at the time of weaning. The outcome of this study revealed increased epigenetic age in oxytocin-exposed animals compared to the saline-exposed group. Oxytocin exposure led to 900 differentially methylated CpG sites (annotated to 589 genes), and two CpG sites (two genes) remained significantly different after correction for multiple comparisons. Differentially methylated CpG sites were enriched in genes known to be involved in regulation of gene expression and neurodevelopment. Using RNA-sequencing, we also found 217 nominally differentially expressed genes (p < .05) in nucleus accumbens, a brain region involved in reward circuitry and social behavior; after corrections for multiple comparisons, six genes remained significantly differentially expressed. Finally, we found that maternal oxytocin administration led to widespread alternative splicing in the nucleus accumbens. These results indicate that oxytocin exposure during birth may have long-lasting epigenetic consequences. A need for further investigation of how oxytocin administration impacts development and behavior throughout the life span is supported by these outcomes.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An in-depth analysis of the polyvagal theory in light of current findings in neuroscience and clinical research 根据神经科学和临床研究的最新发现深入分析多迷走神经理论

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2023-12-27 DOI: 10.1002/dev.22450

Andrea Manzotti, Cristina Panisi, Micol Pivotto, Federico Vinciguerra, Matteo Benedet, Federica Brazzoli, Silvia Zanni, Alberto Comassi, Sara Caputo, Francesco Cerritelli, Marco Chiera

{"title":"An in-depth analysis of the polyvagal theory in light of current findings in neuroscience and clinical research","authors":"Andrea Manzotti, Cristina Panisi, Micol Pivotto, Federico Vinciguerra, Matteo Benedet, Federica Brazzoli, Silvia Zanni, Alberto Comassi, Sara Caputo, Francesco Cerritelli, Marco Chiera","doi":"10.1002/dev.22450","DOIUrl":"10.1002/dev.22450","url":null,"abstract":"The polyvagal theory has led to the understanding of the functions of the autonomic nervous system in biological development in humans, since the vagal system, a key structure within the polyvagal theory, plays a significant role in addressing challenges of the mother–child dyad. This article aims to summarize the neurobiological aspects of the polyvagal theory, highlighting some of its strengths and limitations through the lens of new evidence emerging in several research fields—including comparative anatomy, embryology, epigenetics, psychology, and neuroscience—in the 25 years since the theory's inception. Rereading and incorporating the polyvagal idea in light of modern scientific findings helps to interpret the role of the vagus nerve through the temporal dimension (beginning with intrauterine life) and spatial dimension (due to the numerous connections of the vagus with various structures and systems) in the achievement and maintenance of biopsychosocial well-being, from the uterus to adulthood.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139056581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of fathers in child development from preconception to postnatal influences: Opportunities for the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) program 从孕前到产后影响，父亲在儿童发展中的作用：美国国立卫生研究院环境对儿童健康结果的影响（ECHO）计划的机遇

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2023-12-27 DOI: 10.1002/dev.22451

Elena Jansen, Kristine Marceau, Ruth Sellers, Tong Chen, Craig F. Garfield, Leslie D. Leve, Jenae M. Neiderhiser, Erica L. Spotts, Mary Roary, program collaborators for Environmental influences on Child Health Outcomes

{"title":"The role of fathers in child development from preconception to postnatal influences: Opportunities for the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) program","authors":"Elena Jansen, Kristine Marceau, Ruth Sellers, Tong Chen, Craig F. Garfield, Leslie D. Leve, Jenae M. Neiderhiser, Erica L. Spotts, Mary Roary, program collaborators for Environmental influences on Child Health Outcomes","doi":"10.1002/dev.22451","DOIUrl":"10.1002/dev.22451","url":null,"abstract":"A growing body of literature highlights the important role of paternal health and socioemotional characteristics in child development, from preconception through adolescence. Much of this research addresses the indirect effects of fathers, for instance, their influence on maternal behaviors during the prenatal period or via the relationship with their partner. However, emerging evidence also recognizes the direct role of paternal health and behavior for child health and adjustment across development. This critical review presents evidence of biological and sociocultural influences of fathers on preconception, prenatal, and postnatal contributions to child development. The National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) program incorporates in its central conceptualization the impact of fathers on family and child outcomes. This critical synthesis of the literature focuses on three specific child outcomes in the ECHO program: health outcomes (e.g., obesity), neurodevelopmental outcomes (e.g., emotional, behavioral, psychopathological development), and positive health. We highlight the unique insights gained from the literature to date and provide next steps for future studies on paternal influences.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139056818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adulthood effects of developmental exercise in rats 锻炼对大鼠成年期的影响

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2023-12-19 DOI: 10.1002/dev.22444

Emma C. Perez, Kevin H. Gehm, Valeria Gaume Lobo, Marcelle Olvera, J. Leigh Leasure

{"title":"Adulthood effects of developmental exercise in rats","authors":"Emma C. Perez, Kevin H. Gehm, Valeria Gaume Lobo, Marcelle Olvera, J. Leigh Leasure","doi":"10.1002/dev.22444","DOIUrl":"10.1002/dev.22444","url":null,"abstract":"Exercise is known to promote efficient function of stress circuitry. The developing brain is malleable and thus exercise during adolescence could potentially exert lasting beneficial effects on the stress response that would be detectable in adulthood. The current study determined whether adolescent wheel running was associated with reduced stress response in adulthood, 6 weeks after cessation of exercise. Male and female adolescent rats voluntarily ran for 6 weeks and then were sedentary for 6 weeks prior to 10 days of chronic restraint stress in adulthood. Fecal corticosterone levels were measured during stress, and escape from the restraint tube was assessed on the final day as a proxy for depressive-like behavior. Anxiety-like behavior was measured 24 h later with the elevated plus maze and locomotor behaviors with the open field. Brain and body measurements were taken immediately following behavioral testing. Developmental exercise and adulthood stress both exerted independent effects on physiological and behavioral outcomes in adulthood. Exercise history increased the odds ratio of escape from restraint stress in males, but did not influence other stress-induced behaviors. In summary, exercise early in life exerted lasting effects, but did not substantially alter the adulthood response to restraint stress.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138822447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0