Developmental psychobiology最新文献_第10页

Caudate volume is prospectively associated with irritability in toddlerhood: A preliminary investigation 尾状体体积与幼儿期的易激惹性有前瞻性关联：初步调查

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22465

Alexander J. Dufford, Leigha MacNeill, Yudong Zhang, Ashley Nielsen, Christopher Smyser, Joan L. Luby, Cynthia E. Rogers, Elizabeth Norton, Lauren Wakschlag

{"title":"Caudate volume is prospectively associated with irritability in toddlerhood: A preliminary investigation","authors":"Alexander J. Dufford, Leigha MacNeill, Yudong Zhang, Ashley Nielsen, Christopher Smyser, Joan L. Luby, Cynthia E. Rogers, Elizabeth Norton, Lauren Wakschlag","doi":"10.1002/dev.22465","DOIUrl":"10.1002/dev.22465","url":null,"abstract":"Irritability refers to the dispositional tendency to respond with anger and frustration to environmental challenges or limits, with both mood and behavioral elements. The dimensional spectrum of irritability is an RDoC-informed transdiagnostic marker of psychopathology risk, specifically for the common and modifiable internalizing and externalizing disorders. Despite substantial interest in this robust developmentally based transdiagnostic indicator of psychopathology risk, its early brain markers are understudied. Here, we leveraged high-quality, longitudinal behavioral phenotyping of irritability within an imaging substudy (n = 31) of toddlers, from the When to Worry (W2W) study. We examined prospective associations between volume in three subcortical regions implicated in irritability (the caudate, putamen, and amygdala) around the infants’ first birthday (Baseline) and the dimensional spectrum of observed irritability using the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS) around toddlers’ second birthday (Follow-up). Both left (q = .04, FDR corrected) and right caudate volumes (q = .04, FDR corrected) at Baseline were negatively associated with observed irritability at Follow-up. We did not find support for associations between putamen and amygdala volumes at Baseline and observed irritability at Follow-up. These findings identify early prospective neuroanatomical correlates of toddler irritability and provide preliminary support for the caudate being one important brain region for further investigation regarding the early neural correlates of irritability.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal high-fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring 母鼠高脂肪饮食和妊娠期注射 LPS 会诱发雄性 Wistar 大鼠后代下丘脑炎症和代谢紊乱

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22462

Arthur Rocha-Gomes, Amanda Escobar Teixeira, Alexandre Alves da Silva, Mariana Muniz da Silva, Tatielly Roberta Santos, Túlio Pereira Alvarenga e Castro, Mayara Rodrigues Lessa, Daniel Campos Villela, Tania Regina Riul, Hércules Ribeiro Leite

{"title":"Maternal high-fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring","authors":"Arthur Rocha-Gomes, Amanda Escobar Teixeira, Alexandre Alves da Silva, Mariana Muniz da Silva, Tatielly Roberta Santos, Túlio Pereira Alvarenga e Castro, Mayara Rodrigues Lessa, Daniel Campos Villela, Tania Regina Riul, Hércules Ribeiro Leite","doi":"10.1002/dev.22462","DOIUrl":"10.1002/dev.22462","url":null,"abstract":"Maternal high-fat diet (HFD) is linked to obesity and inflammation, predisposing offspring to metabolic and nutritional disorders. Accordingly, elevated blood levels of lipopolysaccharide (LPS) are also related to inflammation and metabolic complications in the offspring. The aim of this study was to evaluate the effects of the association of maternal HFD (gestation and lactation) and the LPS injection (gestation) on metabolic, inflammatory, and redox status parameters in male adolescent offspring. Female pregnant Wistar rats received randomly a standard or an HFD during gestation and lactation. On gestation Days 8, 10, and 12, half of the females in each group were intraperitonially injected with LPS (0.1 mg.kg−1). After weaning, all offspring received a standard diet. The dams and part of the male offspring were evaluated at weaning (Postnatal Day [PND] 21; food intake and inflammatory parameters), while the rest of the male offspring were evaluated during adolescence (PND50; food intake, redox status, and inflammatory parameters). HFD dams showed during gestation a lower weight gain. After lactation, HFD and LPS+HFD dams reported higher fat mass accumulation and increased interleukin-6 (IL-6) blood levels. HFD and LPS+HFD offspring showed at weaning higher levels of fat mass, body weight, and body length, besides an increased in hypothalamic IL-6 levels. Noteworthy, at PND50, the LPS+HFD offspring showed higher energy intake, fat mass, and hypothalamic IL-6 levels, in addition to an increased sucrose preference. Therefore, LPS+HFD offspring presented a worsening in energy metabolism, which was probably due to persistent hypothalamic inflammation, and also have a predisposition for the consumption of sweet foods.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early development of object manipulation in capuchin monkeys: A naturalistic approach 卷尾猴操控物体的早期发展：自然主义方法

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22458

Guilbert Araujo, Valentina Truppa, Patrícia Izar

{"title":"Early development of object manipulation in capuchin monkeys: A naturalistic approach","authors":"Guilbert Araujo, Valentina Truppa, Patrícia Izar","doi":"10.1002/dev.22458","DOIUrl":"https://doi.org/10.1002/dev.22458","url":null,"abstract":"How human and non-human primates develop their object manipulation skills has been considered an important aspect for understanding the evolution of motor and cognitive abilities in the primate order. Here, we aimed to describe the development of object manipulation from birth to 6 months in robust capuchin monkeys, platyrrhine primates well known for their highly manipulative skills, which partly resemble those observed in catarrhines. To our knowledge, this is the first longitudinal study to investigate the developmental trajectory of object manipulation in capuchin monkeys with a naturalistic approach. For this purpose, eight infants from a wild population of bearded capuchin monkeys were studied in the North-East of Brazil. Data were coded from focal-day recordings of these infants. Our results highlighted the speed and trajectory of change in the development of manipulative action over the first 6 months. In the early stages of development, infants use gentle skills to hold and touch objects. Later, with the acquisition of dexterity and postural control, they begin to exhibit behaviors requiring more complex motor patterns and/or combinatorial actions, such as rubbing and hitting objects. Additionally, we found that the target of manipulation shifted over time, with food interactions gaining prominence. Part of our data parallels those from captive-born individuals, whereas some findings suggest that certain manipulative skills might emerge later in wild capuchins.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of electrodermal activity metrics and their association with child behavior in autism spectrum disorder 对比分析自闭症谱系障碍的皮电活动指标及其与儿童行为的关系

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22461

Jessica L. Greenlee, Emily Lorang, Robert H. Olson, Geovanna Rodriquez, Dasoo Milton Yoon, Sigan Hartley

{"title":"Comparative analysis of electrodermal activity metrics and their association with child behavior in autism spectrum disorder","authors":"Jessica L. Greenlee, Emily Lorang, Robert H. Olson, Geovanna Rodriquez, Dasoo Milton Yoon, Sigan Hartley","doi":"10.1002/dev.22461","DOIUrl":"10.1002/dev.22461","url":null,"abstract":"Researchers are increasingly utilizing physiological data like electrodermal activity (EDA) to understand how stress “gets under the skin.” Results of EDA studies in autistic children are mixed, with some suggesting autistic hyperarousal, others finding hypoarousal, and yet others detecting no difference compared to non-autistics. Some of this variability likely stems from the different techniques used to assess EDA. Therefore, the purpose of this study is to investigate and compare commonly used metrics of EDA (frequency of peaks, average amplitude of peaks, and standard deviation of skin conductance level) using two data processing programs (NeuroKit2 and Ledalab) and their link to observed child behavior. EDA data were collected using Empatica E4 wristbands from 60 autistic children and adolescents (5–18 years old) during a 7-min play interaction with their primary caregiver. The play interaction was coded for a range of child behaviors including mood, social responsiveness, dysregulation, and cooperation. Results indicate a strong correlation between NeuroKit2 and Ledalab and a weak correlation between metrics within each program. Furthermore, the frequency of peaks was associated with more positive child social behaviors, and the magnitude of peaks was associated with less adaptive child behaviors. Recommendations for replication and the need for generalizability of this research are given.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the biological impacts of parent–child relationship dynamics on preschool-aged children who have experienced adversity 研究亲子关系动态对经历逆境的学龄前儿童的生物学影响

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22463

Jesse L. Coe, Teresa Daniels, Lindsay Huffhines, Ronald Seifer, Carmen J. Marsit, Hung-Teh Kao, Barbara Porton, Stephanie H. Parade, Audrey R. Tyrka

{"title":"Examining the biological impacts of parent–child relationship dynamics on preschool-aged children who have experienced adversity","authors":"Jesse L. Coe, Teresa Daniels, Lindsay Huffhines, Ronald Seifer, Carmen J. Marsit, Hung-Teh Kao, Barbara Porton, Stephanie H. Parade, Audrey R. Tyrka","doi":"10.1002/dev.22463","DOIUrl":"10.1002/dev.22463","url":null,"abstract":"Parent–child relationship dynamics have been shown to predict socioemotional and behavioral outcomes for children, but little is known about how they may affect biological development. The aim of this study was to test if observational assessments of parent–child relationship dynamics (cohesion, enmeshment, and disengagement) were associated with three biological indices of early life adversity and downstream health risk: (1) methylation of the glucocorticoid receptor gene (NR3C1), (2) telomere attrition, and (3) mitochondrial biogenesis, indexed by mitochondrial deoxyribonucleic acid (DNA) copy number (mtDNAcn), all of which were measured in children's saliva. We tested hypotheses using a sample of 254 preschool-aged children (M age = 51.04 months) with and without child welfare-substantiated maltreatment (52% with documented case of moderate-severe maltreatment) who were racially and ethnically diverse (17% Black, 40% White, 23% biracial, and 20% other races; 45% Hispanic) and from primarily low-income backgrounds (91% qualified for public assistance). Results of path analyses revealed that: (1) higher parent–child cohesion was associated with lower levels of methylation of NR3C1 exon 1D and longer telomeres, and (2) higher parent–child disengagement was associated with higher levels of methylation of NR3C1 exon 1D and shorter telomeres. Results suggest that parent–child relationship dynamics may have distinct biological effects on children.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139590202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy 母亲的童年逆境与婴儿的表观遗传衰老：孕期睡眠不安的调节作用

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22464

David W. Sosnowski, Darlynn M. Rojo-Wissar, Gang Peng, Stephanie H. Parade, Katherine Sharkey, Cathrine Hoyo, Susan K. Murphy, Raquel G. Hernandez, Sara B. Johnson

{"title":"Maternal childhood adversity and infant epigenetic aging: Moderation by restless sleep during pregnancy","authors":"David W. Sosnowski, Darlynn M. Rojo-Wissar, Gang Peng, Stephanie H. Parade, Katherine Sharkey, Cathrine Hoyo, Susan K. Murphy, Raquel G. Hernandez, Sara B. Johnson","doi":"10.1002/dev.22464","DOIUrl":"10.1002/dev.22464","url":null,"abstract":"Maternal exposure to childhood adversity is associated with detrimental health outcomes throughout the life span and may have implications for offspring. Evidence links maternal adverse childhood experiences (ACEs) to detrimental birth outcomes, yet the impact on the infant's epigenome is unclear. Moreover, maternal sleep habits during pregnancy may influence this association. Here, we explore whether restless sleep during pregnancy moderates the association between exposure to maternal childhood adversity and infant epigenetic age acceleration in 332 mother–infant dyads (56% female; 39% Black; 25% Hispanic). During the second trimester, mothers self-reported childhood adversity and past-week restless sleep; DNA methylation from umbilical vein endothelial cells was used to estimate five epigenetic clocks. Multivariable linear regression was used to test study hypotheses. Despite no evidence of main effects, there was evidence of an interaction between maternal ACEs and restless sleep in predicting infant epigenetic age acceleration using the EPIC gestational age clock. Only infants whose mothers reported exposure to both ACEs and restless sleep demonstrated accelerated epigenetic aging. Results provide preliminary evidence that maternal childhood adversity and sleep may influence the infant epigenome.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits 质量而非数量青少年游戏经验不足会导致内侧前额叶皮层神经元改变和社会认知技能缺陷

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-21 DOI: 10.1002/dev.22456

Jackson R. Ham, Madeline Szabo, Jessica Annor-Bediako, Rachel A. Stark, Andrew N. Iwaniuk, Sergio M. Pellis

{"title":"Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits","authors":"Jackson R. Ham, Madeline Szabo, Jessica Annor-Bediako, Rachel A. Stark, Andrew N. Iwaniuk, Sergio M. Pellis","doi":"10.1002/dev.22456","DOIUrl":"10.1002/dev.22456","url":null,"abstract":"Reduced play experience over the juvenile period leads to adults with impoverished social skills and to anatomical and physiological aberrations of the neurons found in the medial prefrontal cortex (mPFC). Even rearing rats from high-playing strains with low-playing strains show these developmental consequences. In the present study, we evaluated whether low-playing rats benefit from being reared with higher playing peers. To test this, we reared male Fischer 344 rats (F344), typically thought to be a low-playing strain, with a Long–Evans (LE) peer, a relatively high-playing strain. As juveniles, F344 rats reared with LE rats experienced less play and lower quality play compared to those reared with another F344. As adults, the F344 rats reared with LE partners exhibited poorer social skills and the pyramidal neurons of their mPFC had larger dendritic arbors than F344 rats reared with same-strain peers. These findings show that being reared with a more playful partner does not improve developmental outcomes of F344 rats, rather the discordance in the play styles of F344 and LE rats leads to poorer outcomes.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139516252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience of discrimination reported during pregnancy and infant's emerging effortful control 怀孕期间遭受歧视的经历与婴儿新出现的努力控制能力

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-17 DOI: 10.1002/dev.22455

Kenia M. Rivera, Kimberly L. D'Anna-Hernandez, Benjamin L. Hankin, Elysia Poggi Davis, Jenalee R. Doom

{"title":"Experience of discrimination reported during pregnancy and infant's emerging effortful control","authors":"Kenia M. Rivera, Kimberly L. D'Anna-Hernandez, Benjamin L. Hankin, Elysia Poggi Davis, Jenalee R. Doom","doi":"10.1002/dev.22455","DOIUrl":"https://doi.org/10.1002/dev.22455","url":null,"abstract":"Discrimination reported during pregnancy is associated with poorer offspring emotional outcomes. Links with effortful control have yet to be examined. This study investigated whether pregnant individuals’ reports of lifetime racial/ethnic discrimination and everyday discrimination (including but not specific to race/ethnicity) reported during pregnancy were associated with offspring emerging effortful control at 6 months of age. Pregnant individuals (N = 174) and their offspring (93 female infants) participated. During pregnancy, participants completed two discrimination measures: (1) lifetime experience of racial/ethnic discrimination, and (2) everyday discrimination (not specific to race/ethnicity). Parents completed the Infant Behavior Questionnaire—Revised when infants were 6 months old to assess orienting/regulation, a measure of emerging effortful control. Analyses were conducted in a subsample with racially/ethnically marginalized participants and then everyday discrimination analyses were repeated in the full sample. For racially/ethnically marginalized participants, greater everyday discrimination (β = −.27, p = .01) but not greater lifetime experience of racial/ethnic discrimination (β = −.21, p = .06) was associated with poorer infant emerging effortful control. In the full sample, greater everyday discrimination was associated with poorer infant emerging effortful control (β = −.24, p = .002). Greater perceived stress, but not depressive symptoms, at 2 months postnatal mediated the association between everyday discrimination and emerging effortful control. Further research should examine additional biological and behavioral mechanisms by which discrimination reported during pregnancy may affect offspring emerging effortful control.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139488371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental windows for effects of choline and folate on excitatory and inhibitory neurotransmission during human gestation 胆碱和叶酸对人类妊娠期兴奋性和抑制性神经传递影响的发育窗口

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-09 DOI: 10.1002/dev.22453

Sharon K. Hunter, M. Camille Hoffman, Angelo D'Alessandro, Robert Freedman

{"title":"Developmental windows for effects of choline and folate on excitatory and inhibitory neurotransmission during human gestation","authors":"Sharon K. Hunter, M. Camille Hoffman, Angelo D'Alessandro, Robert Freedman","doi":"10.1002/dev.22453","DOIUrl":"https://doi.org/10.1002/dev.22453","url":null,"abstract":"Choline and folate are critical nutrients for fetal brain development, but the timing of their influence during gestation has not been previously characterized. At different periods during gestation, choline stimulation of α7-nicotinic receptors facilitates the conversion of γ-aminobutyric acid (GABA) receptors from excitatory to inhibitory and recruitment of GluR1-R2 receptors for faster excitatory responses to glutamate. The outcome of the fetal development of inhibition and excitation was assessed in 159 newborns by P50 cerebral auditory-evoked responses. Paired stimuli, S1 and S2, were presented 500 ms apart. Higher P50 amplitude in response to S1 (P50S1microV) assesses excitation, and lower P50S2microV assesses inhibition in this paired-stimulus paradigm. The development of inhibition was related solely to maternal choline plasma concentration and folate supplementation at 16 weeks’ gestation. The development of excitation was related only to maternal choline at 28 weeks. Higher maternal choline concentrations later in gestation did not compensate for earlier lower concentrations. At 4 years of age, increased behavior problems on the Child Behavior Checklist 1.5–5 years were related to both newborn inhibition and excitation. The incomplete development of inhibition and excitation associated with lower choline and folate during relatively brief periods of gestation thus has enduring effects on child development.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139406827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal oxytocin treatment at birth increases epigenetic age in male offspring 出生时母体催产素会增加男性后代的表观遗传年龄

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-04 DOI: 10.1002/dev.22452

Joshua S. Danoff, C. Sue Carter, Juozas Gordevičius, Milda Milčiūtė, Robert T. Brooke, Jessica J. Connelly, Allison M. Perkeybile

{"title":"Maternal oxytocin treatment at birth increases epigenetic age in male offspring","authors":"Joshua S. Danoff, C. Sue Carter, Juozas Gordevičius, Milda Milčiūtė, Robert T. Brooke, Jessica J. Connelly, Allison M. Perkeybile","doi":"10.1002/dev.22452","DOIUrl":"https://doi.org/10.1002/dev.22452","url":null,"abstract":"Exogenous oxytocin is widely used to induce or augment labor with little understanding of the impact on offspring development. In rodent models, including the prairie vole (Microtus ochrogaster), it has been shown that oxytocin administered to mothers can affect the nervous system of the offspring with long-lasting behavioral effects especially on sociality. Here, we examined the hypothesis that perinatal oxytocin exposure could have epigenetic and transcriptomic consequences. Prairie voles were exposed to exogenous oxytocin, through injections given to the mother just prior to birth, and were studied at the time of weaning. The outcome of this study revealed increased epigenetic age in oxytocin-exposed animals compared to the saline-exposed group. Oxytocin exposure led to 900 differentially methylated CpG sites (annotated to 589 genes), and two CpG sites (two genes) remained significantly different after correction for multiple comparisons. Differentially methylated CpG sites were enriched in genes known to be involved in regulation of gene expression and neurodevelopment. Using RNA-sequencing, we also found 217 nominally differentially expressed genes (p < .05) in nucleus accumbens, a brain region involved in reward circuitry and social behavior; after corrections for multiple comparisons, six genes remained significantly differentially expressed. Finally, we found that maternal oxytocin administration led to widespread alternative splicing in the nucleus accumbens. These results indicate that oxytocin exposure during birth may have long-lasting epigenetic consequences. A need for further investigation of how oxytocin administration impacts development and behavior throughout the life span is supported by these outcomes.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0