Developmental psychobiology最新文献_第9页

Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate 产前接触丙戊酸钠的幼鼠自闭症样行为和黑质多巴胺能神经元的性别差异

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-02-13 DOI: 10.1002/dev.22469

David Zarate-Lopez, Andrea P. Garzón-Partida, Oscar Gonzalez-Perez, Alma Y. Gálvez-Contreras

{"title":"Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate","authors":"David Zarate-Lopez, Andrea P. Garzón-Partida, Oscar Gonzalez-Perez, Alma Y. Gálvez-Contreras","doi":"10.1002/dev.22469","DOIUrl":"10.1002/dev.22469","url":null,"abstract":"Autism spectrum disorder (ASD) is characterized by deficits in social interaction and communication and repetitive and restricted behaviors. Sex dimorphism in the brain, including midbrain dopaminergic circuits, can explain differences in social behavior impairment and stereotypic behaviors between male and female individuals with ASD. These abnormal patterns may be due to alterations in dopamine synthesis in the ventral tegmental area (VTA) and substantia nigra (SN). We used an autism-like mouse model by prenatal valproic acid (VPA) exposure. CD1 pregnant female mice were injected with 500 mg/kg VPA or 0.9% NaCl as a vehicle on gestational day 12.5. In the offspring, on postnatal day 31, we examined the social and repetitive behaviors and the number of tyrosine hydroxylase (TH)-positive cells in VTA and SN by sex. Male VPA mice showed impaired social behavior and increased repetitive behaviors when compared to male vehicles. In females, we did not find statistically significant differences in social or repetitive behaviors between the groups. Male VPA mice had fewer TH+ cells in the SN than control-vehicle mice. Interestingly, no cellular changes were observed between females. This study supports the notion that sex dimorphism of certain brain regions is involved in the etiopathogenesis and clinical presentation of ASD.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty 发育的最后阶段：青春期（尤其是青春期）大脑皮层的重组和可塑性。

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-02-13 DOI: 10.1002/dev.22468

Janice M. Juraska

{"title":"The last stage of development: The restructuring and plasticity of the cortex during adolescence especially at puberty","authors":"Janice M. Juraska","doi":"10.1002/dev.22468","DOIUrl":"10.1002/dev.22468","url":null,"abstract":"There is considerable evidence of reorganization in the prefrontal cortex during adolescence in humans, as well as in rodents, where the cellular basis can be explored. Studies from my laboratory in the rat medial prefrontal cortex are reviewed here. In general, growth predominates before puberty. Pruning mainly occurs at puberty and after with decreases in the number of synapses, dendrites, and neurons. Perineuronal nets, extracellular structures that control plasticity, are pruned peripubertally only in female rats, which may further open the adolescent prefrontal cortex to environmental influences. This is supported by our recent evidence that exposure to mild stress early, but not late, in adolescence decreases prepulse inhibition. Additionally, exposure to methamphetamine in females early in adolescence increases the number of a major class of inhibitory interneurons, parvalbumin neurons, while the opposite occurs late in adolescence. In females, even estrogen receptor beta mRNA decreases at puberty in the prefrontal cortex. Interestingly, rats of both sexes perform better after puberty on a test of cognitive flexibility in the water maze. Thus, evidence is accruing that adolescence is not a single entity but rather an ongoing set of processes, and environmental effects will differ depending on timing and sex.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Letter to the Editor: Does fetal movement shape the maternal brain? 致编辑的信胎动会塑造母体大脑吗？

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-02-09 DOI: 10.1002/dev.22467

Kathy Ayala, Kristin Voegtline, Helena JV Rutherford

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Epigenetic processes associated with neonatal spinal transection 与新生儿脊柱横断有关的表观遗传过程

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-02-07 DOI: 10.1002/dev.22466

Nicholas J. Collins, Taylor S. Campbell, Aimee L. Bozeman, Alleyna C. Martes, Sydney E. Ross, Tiffany S. Doherty, Michele R. Brumley, Tania L. Roth

{"title":"Epigenetic processes associated with neonatal spinal transection","authors":"Nicholas J. Collins, Taylor S. Campbell, Aimee L. Bozeman, Alleyna C. Martes, Sydney E. Ross, Tiffany S. Doherty, Michele R. Brumley, Tania L. Roth","doi":"10.1002/dev.22466","DOIUrl":"https://doi.org/10.1002/dev.22466","url":null,"abstract":"In early development, the spinal cord in healthy or disease states displays remarkable activity-dependent changes in plasticity, which may be in part due to the increased activity of brain derived neurotrophic factor (BDNF). Indeed, BDNF delivery has been efficacious in partially ameliorating many of the neurobiological and behavioral consequences of spinal cord injury (SCI), making elucidating the role of BDNF in the normative developing and injured spinal cord a critical research focus. Recent work in our laboratory provided evidence for aberrant global and locus-specific epigenetic changes in methylation of the Bdnf gene as a consequence of SCI. In the present study, animals underwent thoracic lesions on P1, with cervical and lumbar tissue being later collected on P7, P14, and P21. Levels of Bdnf expression and methylation (exon IX and exon IV), in addition to global methylation levels were quantified at each timepoint. Results indicated locus-specific reductions of Bdnf expression that was accompanied by a parallel increase in methylation caudal to the injury site, with animals displaying increased Bdnf expression at the P14 timepoint. Together, these findings suggest that epigenetic activity of the Bdnf gene may act as biomarker in the etiology and intervention effort efficacy following SCI.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of poor fetal growth and chronic hyperpalatable diet exposure in adulthood on hippocampal function and feeding patterns in male rats 胎儿发育不良和成年后长期摄入高味食物对雄性大鼠海马功能和摄食模式的影响

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-30 DOI: 10.1002/dev.22459

Amanda Brondani Mucellini, Daniela Pereira Laureano, Márcio Bonesso Alves, Roberta Dalle Molle, Mariana Balbinot Borges, Ana Paula da Ascenção Salvador, Irina Pokhvisneva, Gisele Gus Manfro, Patrícia Pelufo Silveira

{"title":"The impact of poor fetal growth and chronic hyperpalatable diet exposure in adulthood on hippocampal function and feeding patterns in male rats","authors":"Amanda Brondani Mucellini, Daniela Pereira Laureano, Márcio Bonesso Alves, Roberta Dalle Molle, Mariana Balbinot Borges, Ana Paula da Ascenção Salvador, Irina Pokhvisneva, Gisele Gus Manfro, Patrícia Pelufo Silveira","doi":"10.1002/dev.22459","DOIUrl":"https://doi.org/10.1002/dev.22459","url":null,"abstract":"Poor fetal growth affects eating behavior and the mesocorticolimbic system; however, its influence on the hippocampus has been less explored. Brain insulin sensitivity has been linked to developmental plasticity in response to fetal adversity and to cognitive performance following high-fat diet intake. We investigated whether poor fetal growth and exposure to chronic hyperpalatable food in adulthood could influence the recognition of environmental and food cues, eating behavior patterns, and hippocampal insulin signaling. At 60 days of life, we assigned male offspring from a prenatal animal model of 50% food restriction (FR) to receive either a high-fat and -sugar (HFS) diet or standard chow (CON) diet. Behavioral tests were conducted at 140 days, then tissues were collected. HFS groups showed a diminished hippocampal pAkt/Akt ratio. FR-CON and FR-HFS groups had higher levels of suppressor of cytokine signaling 3, compared to control groups. FR groups showed increased exploration of a novel hyperpalatable food, independent of their diet, and HFS groups exhibited overall lower entropy (less random, more predictable eating behavior) when the environment changed. Poor fetal growth and chronic HFS diet in adulthood altered hippocampal insulin signaling and eating patterns, diminishing the flexibility associated with eating behavior in response to extrinsic changes in food availability in the environment.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months 孕期氧化应激生物标志物与 7.5 个月婴儿认知能力之间的关系

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-29 DOI: 10.1002/dev.22457

Stephanie M. Eick, Kaegan Ortlund, Andréa Aguiar, Francheska M. Merced-Nieves, Megan L. Woodbury, Ginger L. Milne, Susan L. Schantz

{"title":"Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months","authors":"Stephanie M. Eick, Kaegan Ortlund, Andréa Aguiar, Francheska M. Merced-Nieves, Megan L. Woodbury, Ginger L. Milne, Susan L. Schantz","doi":"10.1002/dev.22457","DOIUrl":"10.1002/dev.22457","url":null,"abstract":"Oxidative stress has been identified as an important biological pathway leading to neurodevelopmental delay. However, studies assessing the effects of oxidative stress on cognitive outcomes during infancy, a critical period of neurodevelopment, are limited. Our analysis included a subset of those enrolled in the Illinois Kids Development Study (N = 144). Four oxidative stress biomarkers (8-isoprostane-PGF2α, 2,3-dinor-5,6-dihydro-8-iso-PGF2α, 2,3-dinor-8-iso-PGF2α, and prostaglandin-F2α) were measured in second and third trimesters urine and were averaged. Infant cognition was measured using a visual recognition memory task consisting of five blocks, each with one familiarization trial (two identical stimuli) and two test trials (one familiar and one novel stimulus). Outcomes measured included average run duration (a measure of information processing speed), novelty preference (a measure of recognition memory), time to reach familiarization, and shift rate (measures of attention). Linear regression was used to estimate associations between individual oxidative stress biomarkers and each outcome. Increasing 8-isoprostane-PGF2α, 2,3-dinor-8-iso-PGF2α, and prostaglandin-F2α were associated with a decrease in novelty preference (β = −0.02, 95% confidence interval [CI] = −0.03, 0.00; β = −0.02, 95% CI = −0.04, 0.00; β = −0.01, 95% CI = −0.02, 0.00, respectively), as well as a modest increase in shift rate. These findings suggest that oxidative stress may be associated with poorer recognition memory in early infancy.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caudate volume is prospectively associated with irritability in toddlerhood: A preliminary investigation 尾状体体积与幼儿期的易激惹性有前瞻性关联：初步调查

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22465

Alexander J. Dufford, Leigha MacNeill, Yudong Zhang, Ashley Nielsen, Christopher Smyser, Joan L. Luby, Cynthia E. Rogers, Elizabeth Norton, Lauren Wakschlag

{"title":"Caudate volume is prospectively associated with irritability in toddlerhood: A preliminary investigation","authors":"Alexander J. Dufford, Leigha MacNeill, Yudong Zhang, Ashley Nielsen, Christopher Smyser, Joan L. Luby, Cynthia E. Rogers, Elizabeth Norton, Lauren Wakschlag","doi":"10.1002/dev.22465","DOIUrl":"10.1002/dev.22465","url":null,"abstract":"Irritability refers to the dispositional tendency to respond with anger and frustration to environmental challenges or limits, with both mood and behavioral elements. The dimensional spectrum of irritability is an RDoC-informed transdiagnostic marker of psychopathology risk, specifically for the common and modifiable internalizing and externalizing disorders. Despite substantial interest in this robust developmentally based transdiagnostic indicator of psychopathology risk, its early brain markers are understudied. Here, we leveraged high-quality, longitudinal behavioral phenotyping of irritability within an imaging substudy (n = 31) of toddlers, from the When to Worry (W2W) study. We examined prospective associations between volume in three subcortical regions implicated in irritability (the caudate, putamen, and amygdala) around the infants’ first birthday (Baseline) and the dimensional spectrum of observed irritability using the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS) around toddlers’ second birthday (Follow-up). Both left (q = .04, FDR corrected) and right caudate volumes (q = .04, FDR corrected) at Baseline were negatively associated with observed irritability at Follow-up. We did not find support for associations between putamen and amygdala volumes at Baseline and observed irritability at Follow-up. These findings identify early prospective neuroanatomical correlates of toddler irritability and provide preliminary support for the caudate being one important brain region for further investigation regarding the early neural correlates of irritability.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toddlers’ physiological response to parent's mobile device distraction and technoference 幼儿对父母的移动设备分心和技术干预的生理反应

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22460

Chris L. Porter, Sarah M. Coyne, Noah A. Chojnacki, Brandon T. McDaniel, Peter J. Reschke, Laura A. Stockdale

{"title":"Toddlers’ physiological response to parent's mobile device distraction and technoference","authors":"Chris L. Porter, Sarah M. Coyne, Noah A. Chojnacki, Brandon T. McDaniel, Peter J. Reschke, Laura A. Stockdale","doi":"10.1002/dev.22460","DOIUrl":"10.1002/dev.22460","url":null,"abstract":"Given the prevalence of mobile device use, especially among parents of young children, the current study examines the impact of mobile device distraction (technoference) on toddlers’ physiological and emotional functioning. We suspected that toddlers’ would demonstrate difficultly maintaining physiological and emotional homeostasis when parents became distracted by a mobile device. In this study, we examined toddlers’ (N = 129, M age = 29.05 months) physiological and behavioral responses across three conditions in an induced technoference task that mimicked elements of a traditional still face paradigm (i.e., social engagement, phone distraction, and social recovery). Similar to previous studies employing still face with younger infants, a majority of toddlers demonstrated a loss of positive affective tone mirrored by heart rate increase and respiratory sinus arrhythmia (RSA) decrease (vagal withdrawal) during the phone distraction condition relative to the initial and final social engagement conditions. However, some toddlers demonstrated vagal activation (RSA increase) to parents’ phone distraction. Greater RSA withdrawal was linked to decreased positive affect and increased negative affect for children during parents’ phone distraction. Parents who reported higher levels of technoference were more likely to have children who demonstrated lower vagal reactivity (greater vagal withdrawal) to parents’ phone distraction while parents attitudes about technoference (e.g., “it is okay to use a mobile device in front of my child”) was found to be linked to higher RSA reactivity (greater vagal activation). Findings are discussed in relation to Porges’ polyvagal theory and the possible role that interactive dynamics play in children's emerging regulatory systems.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early development of object manipulation in capuchin monkeys: A naturalistic approach 卷尾猴操控物体的早期发展：自然主义方法

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22458

Guilbert Araujo, Valentina Truppa, Patrícia Izar

{"title":"Early development of object manipulation in capuchin monkeys: A naturalistic approach","authors":"Guilbert Araujo, Valentina Truppa, Patrícia Izar","doi":"10.1002/dev.22458","DOIUrl":"https://doi.org/10.1002/dev.22458","url":null,"abstract":"How human and non-human primates develop their object manipulation skills has been considered an important aspect for understanding the evolution of motor and cognitive abilities in the primate order. Here, we aimed to describe the development of object manipulation from birth to 6 months in robust capuchin monkeys, platyrrhine primates well known for their highly manipulative skills, which partly resemble those observed in catarrhines. To our knowledge, this is the first longitudinal study to investigate the developmental trajectory of object manipulation in capuchin monkeys with a naturalistic approach. For this purpose, eight infants from a wild population of bearded capuchin monkeys were studied in the North-East of Brazil. Data were coded from focal-day recordings of these infants. Our results highlighted the speed and trajectory of change in the development of manipulative action over the first 6 months. In the early stages of development, infants use gentle skills to hold and touch objects. Later, with the acquisition of dexterity and postural control, they begin to exhibit behaviors requiring more complex motor patterns and/or combinatorial actions, such as rubbing and hitting objects. Additionally, we found that the target of manipulation shifted over time, with food interactions gaining prominence. Part of our data parallels those from captive-born individuals, whereas some findings suggest that certain manipulative skills might emerge later in wild capuchins.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Maternal high-fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring 母鼠高脂肪饮食和妊娠期注射 LPS 会诱发雄性 Wistar 大鼠后代下丘脑炎症和代谢紊乱

IF 2.2 4区心理学

Developmental psychobiology Pub Date : 2024-01-28 DOI: 10.1002/dev.22462

Arthur Rocha-Gomes, Amanda Escobar Teixeira, Alexandre Alves da Silva, Mariana Muniz da Silva, Tatielly Roberta Santos, Túlio Pereira Alvarenga e Castro, Mayara Rodrigues Lessa, Daniel Campos Villela, Tania Regina Riul, Hércules Ribeiro Leite

{"title":"Maternal high-fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring","authors":"Arthur Rocha-Gomes, Amanda Escobar Teixeira, Alexandre Alves da Silva, Mariana Muniz da Silva, Tatielly Roberta Santos, Túlio Pereira Alvarenga e Castro, Mayara Rodrigues Lessa, Daniel Campos Villela, Tania Regina Riul, Hércules Ribeiro Leite","doi":"10.1002/dev.22462","DOIUrl":"10.1002/dev.22462","url":null,"abstract":"Maternal high-fat diet (HFD) is linked to obesity and inflammation, predisposing offspring to metabolic and nutritional disorders. Accordingly, elevated blood levels of lipopolysaccharide (LPS) are also related to inflammation and metabolic complications in the offspring. The aim of this study was to evaluate the effects of the association of maternal HFD (gestation and lactation) and the LPS injection (gestation) on metabolic, inflammatory, and redox status parameters in male adolescent offspring. Female pregnant Wistar rats received randomly a standard or an HFD during gestation and lactation. On gestation Days 8, 10, and 12, half of the females in each group were intraperitonially injected with LPS (0.1 mg.kg−1). After weaning, all offspring received a standard diet. The dams and part of the male offspring were evaluated at weaning (Postnatal Day [PND] 21; food intake and inflammatory parameters), while the rest of the male offspring were evaluated during adolescence (PND50; food intake, redox status, and inflammatory parameters). HFD dams showed during gestation a lower weight gain. After lactation, HFD and LPS+HFD dams reported higher fat mass accumulation and increased interleukin-6 (IL-6) blood levels. HFD and LPS+HFD offspring showed at weaning higher levels of fat mass, body weight, and body length, besides an increased in hypothalamic IL-6 levels. Noteworthy, at PND50, the LPS+HFD offspring showed higher energy intake, fat mass, and hypothalamic IL-6 levels, in addition to an increased sucrose preference. Therefore, LPS+HFD offspring presented a worsening in energy metabolism, which was probably due to persistent hypothalamic inflammation, and also have a predisposition for the consumption of sweet foods.","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139587397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0