生命早期的稀缺性-超前性对雄性和雌性大鼠成熟期的影响

IF 1.8 4区 心理学 Q3 DEVELOPMENTAL BIOLOGY
Erin Lauraine, Sasha Oak, Christine H. Nguyen, Millie Rincón-Cortés
{"title":"生命早期的稀缺性-超前性对雄性和雌性大鼠成熟期的影响","authors":"Erin Lauraine,&nbsp;Sasha Oak,&nbsp;Christine H. Nguyen,&nbsp;Millie Rincón-Cortés","doi":"10.1002/dev.22559","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Although many studies have shown a long-term negative impact of early life adversity (ELA) in rodents, literature regarding its effects on maturational milestones in rats is scarce. Available evidence suggests that ELA interferes with normal growth and development in rodents and that effects may be sex-dependent even at an early age. In accordance, we hypothesized that early life scarcity-adversity would impair physical and reflex development in male and female rats. To test this, we used an early life resource scarcity paradigm based on reducing home cage bedding during postnatal days (PND) 2–9 and assessed physical landmarks by measuring weight gain, incisor presence, fur development, and eye opening. We also evaluated the impact of early life scarcity-adversity on developmental reflexes by measuring surface righting and grasp reflexes, negative geotaxis, cliff avoidance, bar holding, and auditory startle. Early life scarcity-adversity resulted in earlier complete lower incisor presence in males (PND 6), impaired surface righting (PND 6) and grasp reflexes (PND 8) in both sexes, and impaired cliff avoidance responses in females (PND 12). These results extend previous research examining the effects of ELA on developing male and female rodents by showing that it negatively impacts a subset of physical landmarks and developmental reflexes in a sex-dependent manner.</p>\n </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats\",\"authors\":\"Erin Lauraine,&nbsp;Sasha Oak,&nbsp;Christine H. Nguyen,&nbsp;Millie Rincón-Cortés\",\"doi\":\"10.1002/dev.22559\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Although many studies have shown a long-term negative impact of early life adversity (ELA) in rodents, literature regarding its effects on maturational milestones in rats is scarce. Available evidence suggests that ELA interferes with normal growth and development in rodents and that effects may be sex-dependent even at an early age. In accordance, we hypothesized that early life scarcity-adversity would impair physical and reflex development in male and female rats. To test this, we used an early life resource scarcity paradigm based on reducing home cage bedding during postnatal days (PND) 2–9 and assessed physical landmarks by measuring weight gain, incisor presence, fur development, and eye opening. We also evaluated the impact of early life scarcity-adversity on developmental reflexes by measuring surface righting and grasp reflexes, negative geotaxis, cliff avoidance, bar holding, and auditory startle. Early life scarcity-adversity resulted in earlier complete lower incisor presence in males (PND 6), impaired surface righting (PND 6) and grasp reflexes (PND 8) in both sexes, and impaired cliff avoidance responses in females (PND 12). These results extend previous research examining the effects of ELA on developing male and female rodents by showing that it negatively impacts a subset of physical landmarks and developmental reflexes in a sex-dependent manner.</p>\\n </div>\",\"PeriodicalId\":11086,\"journal\":{\"name\":\"Developmental psychobiology\",\"volume\":\"66 7\",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental psychobiology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/dev.22559\",\"RegionNum\":4,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental psychobiology","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dev.22559","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

尽管许多研究表明早期生活逆境(ELA)对啮齿类动物有长期的负面影响,但有关其对大鼠成熟里程碑影响的文献却很少。现有证据表明,ELA 会干扰啮齿类动物的正常生长和发育,而且即使在幼年时期,其影响也可能是性别依赖性的。因此,我们假设生命早期的匮乏逆境会损害雄性和雌性大鼠的身体和反射发育。为了验证这一假设,我们采用了一种早期生命资源匮乏范例,即在出生后第 2-9 天减少笼中垫料,并通过测量体重增加、门齿存在、皮毛发育和睁眼情况来评估身体标志物。我们还通过测量表面扶正反射和抓握反射、负地轴、悬崖回避、单杠握持和听觉惊吓,评估了早期生命稀缺逆境对发育反射的影响。早期生命稀缺-逆境导致雄性(PND 6)较早出现完整的下门牙,雌雄均出现表面扶正(PND 6)和抓握反射(PND 8)受损,雌性(PND 12)悬崖回避反应受损。这些结果表明,ELA会以性别依赖的方式对特定的物理标志和发育反射产生负面影响,从而扩展了以往研究ELA对发育中的雄性和雌性啮齿动物的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats

Although many studies have shown a long-term negative impact of early life adversity (ELA) in rodents, literature regarding its effects on maturational milestones in rats is scarce. Available evidence suggests that ELA interferes with normal growth and development in rodents and that effects may be sex-dependent even at an early age. In accordance, we hypothesized that early life scarcity-adversity would impair physical and reflex development in male and female rats. To test this, we used an early life resource scarcity paradigm based on reducing home cage bedding during postnatal days (PND) 2–9 and assessed physical landmarks by measuring weight gain, incisor presence, fur development, and eye opening. We also evaluated the impact of early life scarcity-adversity on developmental reflexes by measuring surface righting and grasp reflexes, negative geotaxis, cliff avoidance, bar holding, and auditory startle. Early life scarcity-adversity resulted in earlier complete lower incisor presence in males (PND 6), impaired surface righting (PND 6) and grasp reflexes (PND 8) in both sexes, and impaired cliff avoidance responses in females (PND 12). These results extend previous research examining the effects of ELA on developing male and female rodents by showing that it negatively impacts a subset of physical landmarks and developmental reflexes in a sex-dependent manner.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Developmental psychobiology
Developmental psychobiology 生物-发育生物学
CiteScore
4.20
自引率
18.20%
发文量
125
审稿时长
6-12 weeks
期刊介绍: Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信