Developmental psychobiology最新文献

{"title":"A dog's life: Early life histories influence methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes, cortisol levels, and attachment styles","authors":"Samantha L. Awalt,&nbsp;Lidia Boghean,&nbsp;David Klinkebiel,&nbsp;Rosemary Strasser","doi":"10.1002/dev.22482","DOIUrl":"10.1002/dev.22482","url":null,"abstract":"<p>Early life deprivation and stress can contribute to life-long, problematic consequences, including epigenetic variations related to behavior and health. Domestic dogs share human environments and social–cognitive traits, making them a promising comparative model to examine developmental plasticity. We examined 47 owner–dog dyads, including dogs rescued from abusive or neglectful environments, and matched control dogs for changes in DNA methylation of glucocorticoid (<i>NR3C1</i>) and oxytocin (<i>OXTR</i>) receptor genes previously shown to be affected by early life stress in other species including humans. We used an attachment paradigm, which included a separation event to examine cortisol levels and owner–dog attachment styles. Overall, dogs with adverse histories had different <i>NR3C1</i> methylation patterns as a function of age and less <i>OXTR</i> methylation than comparison dogs. Dogs with adverse histories did not differ in their cortisol change from baseline to poststressor from comparison dogs, but the change in cortisol was associated with <i>NR3C1</i> methylation. In addition, dogs with a history of early life stress had more insecure attachment styles; for every unit increase of <i>OXTR</i> methylation, the odds increased for insecure attachment style. This study demonstrates that adverse life histories lead to methylation differences, resulting in the hypothalamic–pituitary–adrenal (HPA) axis's dysregulation and differences in behavioral phenotypes.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions among stress, behavioral inhibition, and delta–beta coupling predict adolescent anxiety during the COVID-19 pandemic","authors":"Michelle L. Ramos,&nbsp;Anna M. Zhou,&nbsp;Marisa N. Lytle,&nbsp;Sarah Myruski,&nbsp;Koraly Pérez-Edgar,&nbsp;Kristin A. Buss","doi":"10.1002/dev.22485","DOIUrl":"10.1002/dev.22485","url":null,"abstract":"<p>The COVID-19 pandemic brought about unprecedented changes and uncertainty to the daily lives of youth. The range of adjustment in light of a near-universal experience of COVID restrictions highlights the importance of identifying factors that may render some individuals more susceptible to heightened levels of anxiety during stressful life events than others. Two risk factors to consider are temperamental behavioral inhibition (BI) and difficulties in emotion regulation (ER). As such, the current paper focused on BI examined prior to COVID, because of its developmental link to anxiety and ER, as difficulties may be associated with differences in anxiety. We examined a neurocognitive marker of ER processes, delta–beta coupling (DBC). The current paper had two goals: (1) to examine BI in relation to COVID-related worry and social anxiety experienced during the pandemic, and (2) to explore the role of individual differences in early DBC in the relationship between BI and anxiety outcomes 6 months apart during COVID-19 (<i>n </i>= 86; T1 <i>M</i>_age = 15.95, <i>SD </i>= 1.73; T6 <i>M</i>_age = 16.43, <i>SD </i>= 1.73). We found support for the moderating role of DBC in the relationship between BI levels and social anxiety disorder (SAD) symptom severity during the pandemic. Here, high BI was predictive of increased SAD symptom levels in adolescents with stronger DBC.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting respiratory sinus arrhythmia moderates the within-person relations of parental emotional expressivity and children's prosocial behaviors","authors":"Runzhu Zhang,&nbsp;Zhenhong Wang","doi":"10.1002/dev.22483","DOIUrl":"10.1002/dev.22483","url":null,"abstract":"<p>Parental supportive emotional expressivity could contribute to children's prosocial behaviors, and such an effect may differ for children with different levels of resting respiratory sinus arrhythmia (RSA). This study disentangled the stable differences across dyads (i.e., between-person effects) from the dynamic associations between parental expressivity and children's prosocial behaviors within dyads (i.e., within-person effects) and determined how resting RSA functioned as a susceptibility factor in such effects. The longitudinal design consisted of three measurements with a 1-year interval performed among 208 school-aged children (48.6% girls; Han nationality) and their parents (153 mothers and 55 fathers). The initial measurement was conducted when the children were 7 years old (<i>M</i>_age = 7.13, <i>SD</i>_age = .33). Resting RSA was calculated at the first measurement; parents reported children's prosocial behaviors and parental expressivity at each of the three measurements. The results demonstrated significant between- and within-person effects of parental expressivity on children's prosocial behaviors and found a moderating role of children's resting RSA in the within-person effects. These findings suggest that children displayed more prosocial behaviors when parents showed more supportive expressivity both across and within dyads, and higher resting RSA operated as a differential susceptibility factor in the intraindividual fluctuations in parental expressivity.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of epigenetic mechanisms in the long-term effects of early-life adversity and mother–infant relationship on physiology and behavior of offspring in laboratory rats and mice","authors":"Olga V. Burenkova,&nbsp;Elena L. Grigorenko","doi":"10.1002/dev.22479","DOIUrl":"10.1002/dev.22479","url":null,"abstract":"<p>Maternal care during the early postnatal period of altricial mammals is a key factor in the survival and adaptation of offspring to environmental conditions. Natural variations in maternal care and experimental manipulations with maternal–child relationships modeling early-life adversity (ELA) in laboratory rats and mice have a strong long-term influence on the physiology and behavior of offspring in rats and mice. This literature review is devoted to the latest research on the role of epigenetic mechanisms in these effects of ELA and mother–infant relationship, with a focus on the regulation of hypothalamic–pituitary–adrenal axis and brain-derived neurotrophic factor. An important part of this review is dedicated to pharmacological interventions and epigenetic editing as tools for studying the causal role of epigenetic mechanisms in the development of physiological and behavioral profiles. A special section of the manuscript will discuss the translational potential of the discussed research.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary investigation of epigenome-wide DNA methylation and temperament during infancy","authors":"John Leri,&nbsp;Jingwen Liu,&nbsp;Maria Kelly,&nbsp;Darlene A. Kertes","doi":"10.1002/dev.22475","DOIUrl":"10.1002/dev.22475","url":null,"abstract":"<p>This study provides preliminary evidence for an epigenetic architecture of infant temperament. At 12 months of age, blood was collected and assayed for DNA methylation and maternally reported infant temperament was assessed using the Infant Behavior Questionnaire in 67 mother–infant dyads. Epigenome-wide analyses showed that the higher order temperament dimensions Surgency and Negative Affect were associated with DNA methylation. The epigenetic signatures of Surgency and Negative Affect were situated at genes involved in synaptic signaling and plasticity. Although replication is required, these results are consistent with a biologically based model of temperament, create new avenues for hypothesis-driven research into epigenetic pathways that underlie individual differences in temperament, and demonstrate that infant temperament has a widespread epigenetic signature in the methylome.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synaptic pruning during adolescence shapes adult social behavior in both males and females","authors":"Julia M. Kirkland,&nbsp;Erin L. Edgar,&nbsp;Ishan Patel,&nbsp;Paul Feustel,&nbsp;Sophie Belin,&nbsp;Ashley M. Kopec","doi":"10.1002/dev.22473","DOIUrl":"10.1002/dev.22473","url":null,"abstract":"<p>Evolutionarily conserved, peer-directed social behaviors are essential to participate in many aspects of human society. These behaviors directly impact psychological, physiological, and behavioral maturation. Adolescence is an evolutionarily conserved period during which reward-related behaviors, including social behaviors, develop via developmental plasticity in the mesolimbic dopaminergic “reward” circuitry of the brain. The nucleus accumbens (NAc) is an intermediate reward relay center that develops during adolescence and mediates both social behaviors and dopaminergic signaling. In several developing brain regions, synaptic pruning mediated by microglia, the resident immune cells of the brain, is important for normal behavioral development. We previously demonstrated that during adolescence, in rats, microglial synaptic pruning shapes the development of NAc and social play behavior in males and females. In this report, we hypothesize that interrupting microglial pruning in NAc during adolescence will have persistent effects on male and female social behavior in adulthood. We found that inhibiting microglial pruning in the NAc during adolescence had different effects on social behavior in males and females. In males, inhibiting pruning increased familiar exploration and increased nonsocial contact. In females, inhibiting pruning did not change familiar exploration behavior but increased active social interaction. This leads us to infer that <i>naturally occurring</i> NAc pruning serves to reduce social behaviors toward a familiar conspecific in both males and females.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the impact of prenatal maternal internalizing symptoms and socioeconomic status on children's frontal alpha asymmetry and psychopathology","authors":"Alexis Hernandez,&nbsp;Ayesha Sania,&nbsp;Maureen E. Bowers,&nbsp;Stephanie C. Leach,&nbsp;Marco McSweeney,&nbsp;Lydia Yoder,&nbsp;William Fifer,&nbsp;Amy J. Elliott,&nbsp;Lauren Shuffrey,&nbsp;Virginia Rauh,&nbsp;Deana Around Him,&nbsp;Nathan A. Fox,&nbsp;Santiago Morales","doi":"10.1002/dev.22476","DOIUrl":"10.1002/dev.22476","url":null,"abstract":"<p>Prenatal maternal internalizing psychopathology (depression and anxiety) and socioeconomic status (SES) have been independently associated with higher risk for internalizing and externalizing problems in children. However, the pathways behind these associations are not well understood. Numerous studies have linked greater right frontal alpha asymmetry to internalizing problems; however, findings have been mixed. Several studies have also linked maternal internalizing psychopathology to children's frontal alpha asymmetry. Additionally, emerging studies have linked SES to children's frontal alpha asymmetry. To date, only a limited number of studies have examined these associations within a longitudinal design, and the majority have utilized relatively small samples. The current preregistered study utilizes data from a large prospective study of young children (<i>N</i> = 415; Mean_age = 7.27 years; Range_age = 5–11 years) to examine the association between prenatal maternal internalizing symptoms, children's frontal alpha asymmetry, and behavior problems. Prenatal maternal internalizing symptoms did not predict children's frontal alpha asymmetry, and there was no association between frontal alpha asymmetry and behavior problems. However, mothers’ internalizing symptoms during pregnancy predicted children's internalizing and externalizing outcomes. Non-preregistered analyses showed that lower prenatal maternal SES predicted greater child right frontal alpha asymmetry and internalizing problems. Additional non-preregistered analyses did not find evidence for frontal alpha asymmetry as a moderator of the relation between prenatal maternal internalizing psychopathology and SES to children's behavior problems. Future research should examine the impact of SES on children's frontal alpha asymmetry in high-risk samples.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental Psychobiology Reviewer Recognition for 2023","authors":"","doi":"10.1002/dev.22472","DOIUrl":"10.1002/dev.22472","url":null,"abstract":"","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive neonatal procedural pain affects stress-induced plasma corticosterone increase in young adult females but not in male rats","authors":"Mathilde Baudat,&nbsp;Sinno H. P. Simons,&nbsp;Elbert A. J. Joosten","doi":"10.1002/dev.22478","DOIUrl":"10.1002/dev.22478","url":null,"abstract":"<p>Exposure to repetitive painful procedures in the neonatal intensive care unit results in long-lasting effects, especially visible after a “second hit” in adulthood. As the nociceptive system and the hypothalamic–pituitary–adrenal (HPA) axis interact and are vulnerable in early life, repetitive painful procedures in neonates may affect later-life HPA axis reactivity. The first aim of the present study was to investigate the effects of repetitive neonatal procedural pain on plasma corticosterone levels after mild acute stress (MAS) in young adult rats. Second, the study examined if MAS acts as a “second hit” and affects mechanical sensitivity. Fifty-two rats were either needle pricked four times a day, disturbed, or left undisturbed during the first neonatal week. At 8 weeks, the animals were subjected to MAS, and plasma was collected before (t0), after MAS (t20), and at recovery (t60). Corticosterone levels were analyzed using an enzyme-linked immunosorbent assay, and mechanical sensitivity was assessed with von Frey filaments. Results demonstrate that repetitive neonatal procedural pain reduces stress-induced plasma corticosterone increase after MAS only in young adult females and not in males. Furthermore, MAS does not affect mechanical sensitivity in young adult rats. Altogether, the results suggest an age- and sex-dependent effect of repetitive neonatal procedural pain on HPA axis reprogramming.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between disordered eating, internalizing symptoms, and behavioral and neural correlates of response inhibition in preadolescence","authors":"Kai S. Thomas,&nbsp;Catherine R. G. Jones,&nbsp;Marc O. Williams,&nbsp;Ross E. Vanderwert","doi":"10.1002/dev.22477","DOIUrl":"10.1002/dev.22477","url":null,"abstract":"<p>Response inhibition difficulties are reported in individuals with eating disorders (EDs), anxiety, and depression. Although ED symptoms and internalizing symptoms co-occur in preadolescence, there is limited research examining associations between these symptoms and response inhibition in this age group. This study is the first to investigate the associations between behavioral and neural markers of response inhibition, disordered eating (DE), and internalizing symptoms in a community sample of preadolescents. Forty-eight children (<i>M</i> age = 10.95 years, 56.3% male) completed a Go/NoGo task, whereas electroencephalography was recorded. Self-report measures of DE and internalizing symptoms were collected. Higher levels of anxiety and depression were associated with neural markers of suboptimal response inhibition (attenuated P3_NoGo amplitudes) in preadolescence. In contrast, higher levels of depression were associated with greater response inhibition at a behavioral level. These findings suggest internalizing symptoms in preadolescence are associated with P3-indexed difficulties in evaluation and monitoring, but these are not sufficient to disrupt behavioral performance on a response inhibition task. This pattern may reflect engagement of compensatory processes to support task performance. DE was not significantly associated with response inhibition, suggesting that difficulties in response inhibition may only be reliably observed in more chronic and severe DE and ED presentations.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}