幼儿期的性情与肠道微生物群的组成和多样性有关。

IF 1.8 4区 心理学 Q3 DEVELOPMENTAL BIOLOGY
Eriko Ueda, Michiko Matsunaga, Hideaki Fujihara, Takamasa Kajiwara, Aya K. Takeda, Satoshi Watanabe, Keisuke Hagihara, Masako Myowa
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引用次数: 0

摘要

气质是预测人类心理健康、认知和情感发展的关键因素。据报道,虽然人类的恐惧行为与婴儿期的肠道微生物群有关,但婴儿肠道微生物群在最初 5 年中会发生巨大变化,此时肠道微生物群的多样性和组成已经确立。这一时期对参与情绪调节的前额叶皮层的发育至关重要。因此,本研究调查了 284 名 3-4 岁学龄前儿童的气质与肠道微生物群之间的关系。儿童气质通过母亲对儿童行为问卷的报告进行评估。通过对粪便样本进行 16S rRNA 测序,对肠道微生物群(α/β 多样性和菌属丰度)进行了评估。抗炎细菌(如粪杆菌)的低丰度和促炎细菌(如卵菌、黄杆菌)的高丰度与较高的消极情绪和应激反应(即消极情绪,β = -0.17,p = 0.004)以及较低的积极情绪和奖励追求(即急躁/外向,β = 0.15,p = 0.013)有关。此外,肠道微生物群多样性还与启动反应的速度有关(即冲动性,急躁/外向的一个特定方面,β = 0.16,p = 0.008)。这项研究深入揭示了气质的生物机制,为确定心理/情绪风险的预测标记迈出了重要一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Temperament in Early Childhood Is Associated With Gut Microbiota Composition and Diversity

Temperament in Early Childhood Is Associated With Gut Microbiota Composition and Diversity

Temperament is a key predictor of human mental health and cognitive and emotional development. Although human fear behavior is reportedly associated with gut microbiome in infancy, infant gut microbiota changes dramatically during the first 5 years, when the diversity and composition of gut microbiome are established. This period is crucial for the development of the prefrontal cortex, which is involved in emotion regulation. Therefore, this study investigated the relationship between temperament and gut microbiota in 284 preschool children aged 3–4 years. Child temperament was assessed by maternal reports of the Children's Behavior Questionnaire. Gut microbiota (alpha/beta diversity and genera abundance) was evaluated using 16S rRNA sequencing of stool samples. A low abundance of anti-inflammatory bacteria (e.g., Faecalibacterium) and a high abundance of pro-inflammatory bacteria (e.g., Eggerthella, Flavonifractor) were associated with higher negative emotionality and stress response (i.e., negative affectivity, β = −0.17, p = 0.004) and lower positive emotionality and reward-seeking (i.e., surgency/extraversion, β = 0.15, p = 0.013). Additionally, gut microbiota diversity was associated with speed of response initiation (i.e., impulsivity, a specific aspect of surgency/extraversion, β = 0.16, p = 0.008). This study provides insight into the biological mechanisms of temperament and takes important steps toward identifying predictive markers of psychological/emotional risk.

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来源期刊
Developmental psychobiology
Developmental psychobiology 生物-发育生物学
CiteScore
4.20
自引率
18.20%
发文量
125
审稿时长
6-12 weeks
期刊介绍: Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.
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