发育过程中昼夜α-淀粉酶和皮质醇对焦虑和抑郁的不同预测证据

IF 1.8 4区 心理学 Q3 DEVELOPMENTAL BIOLOGY
Bethany H. McCurdy, Carl F. Weems, Travis Bradley, Ryan Matlow, Victor G. Carrión
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引用次数: 0

摘要

研究和理论表明,神经内分泌功能在情绪发育过程中起着重要作用,尤其是在高压力条件下。我们提供了实证数据来阐明α-淀粉酶(AA)与皮质醇之间的关联,并测试了AA、皮质醇与儿童焦虑、抑郁和创伤后应激症状之间的不同联系。研究人员对从暴力事件频发的低收入社区招募的儿童(n = 100;平均年龄 = 10,SD = 0.64;79% 为拉丁裔;67% 接受免费或减免午餐)进行了 AA 和皮质醇昼夜水平评估,同时还评估了焦虑、抑郁和创伤后应激症状 (PTSS)。焦虑症状的加重与较陡的 AA 线性斜率有关,早上的 AA 水平较高,而晚上的 AA 水平较低。当将 PTSS 纳入模型时,抑郁症与不同的 AA 立方轨迹相关。焦虑也预示着皮质醇的不同立方昼夜趋势,因此焦虑症状越严重,晚上的皮质醇水平就相对越高。同样,如果将 PTSS 纳入模型,抑郁症状也会预测昼夜的立方趋势,与自我报告抑郁症状较少的青少年相比,抑郁症状的升高与较低的觉醒和中午皮质醇水平相关,而与较高的晚间皮质醇水平相反。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evidence of Differential Prediction of Anxiety and Depression by Diurnal Alpha-Amylase and Cortisol in Development

Evidence of Differential Prediction of Anxiety and Depression by Diurnal Alpha-Amylase and Cortisol in Development

Research and theory suggest an important role of neuroendocrine function in emotional development, particularly under conditions of elevated stress. We provide empirical data to clarify associations between alpha-amylase (AA) and cortisol as well as test the differential linkages among AA, cortisol, and symptoms of anxiety, depression, and posttraumatic stress in children. Children recruited from a low-income elevated violence community (n = 100; mean age = 10, SD = 0.64; 79% Latino; 67% received free or reduced lunch) were assessed on diurnal levels of AA and cortisol along with assessments of anxiety, depression, and posttraumatic stress symptoms (PTSS). Elevated anxiety symptoms were associated with steeper linear slopes of AA with higher levels of AA in the morning but lower levels of AA in the evening. Depression was associated with differential cubic trajectories of AA when PTSSs were included in the model. Anxiety also predicted differential cubic diurnal trends in cortisol, such that greater anxiety symptoms were associated with relatively higher levels of cortisol in the evening. Again, depression symptoms when PTSS were included predicted diurnal cubic trends with elevated depression associated with lower awakening and midday cortisol that reversed to higher evening cortisol compared to youth with fewer self-reported depression symptoms.

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来源期刊
Developmental psychobiology
Developmental psychobiology 生物-发育生物学
CiteScore
4.20
自引率
18.20%
发文量
125
审稿时长
6-12 weeks
期刊介绍: Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.
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