Greater Frontoparietal Connectivity During Task Engagement Among Toddlers With Parent-Reported Inattention

IF 1.8 4区心理学 Q3 DEVELOPMENTAL BIOLOGY

Developmental psychobiology Pub Date : 2024-09-05 DOI:10.1002/dev.22546

Heather M. Joseph, Hendrik Santosa, Nadiyah Fisher, Theodore Huppert, Judith K. Morgan

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引用次数: 0

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with lifelong impairments. ADHD-related behaviors have been observed as early as toddlerhood for children who later develop ADHD. Children with ADHD have disrupted connectivity in neural circuitry involved in executive control of attention, including the prefrontal cortex (PFC) and dorsal attention network (DAN). It is not known if these alterations in connectivity can be identified before the onset of ADHD. Children (N = 51) 1.5–3 years old were assessed using functional near-infrared spectroscopy while engaging with a book. The relation between mother-reported ADHD-related behaviors and neural connectivity, computed using robust innovation-based correlation, was examined. Task engagement was high across the sample and unrelated to ADHD-related behaviors. Observed attention was associated with greater connectivity between the right lateral PFC and the right temporal parietal junction (TPJ). Children with greater ADHD-related behaviors had greater frontoparietal connectivity, particularly between the PFC bilaterally and the right TPJ. Toddlers at risk for developing ADHD may require increased frontoparietal connectivity to sustain attention. Future work is needed to examine early interventions that enhance developing attention and their effect on neural connectivity between the PFC and attention networks.

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家长反映注意力不集中的幼儿在任务参与过程中前额叶连接性更强。

注意缺陷多动障碍（ADHD）是一种常见的神经发育障碍，会造成终身损害。早在蹒跚学步时，就能观察到与多动症相关的行为，这些儿童后来发展成了多动症。多动症患儿的神经回路（包括前额叶皮质（PFC）和背侧注意力网络（DAN））中涉及注意力执行控制的连接被破坏。目前尚不清楚这些连接性改变是否能在多动症发病前被发现。我们使用功能性近红外光谱对 1.5-3 岁的儿童（N = 51）在看书时进行了评估。采用基于创新的稳健相关性计算方法，研究了母亲报告的多动症相关行为与神经连通性之间的关系。所有样本的任务参与度都很高，且与多动症相关行为无关。观察到的注意力与右外侧前脑皮层和右侧颞顶叶交界处（TPJ）之间更强的连通性有关。多动症相关行为较多的儿童的额顶叶连接性较强，尤其是双侧前额叶与右侧颞顶交界处之间的连接性。有患多动症风险的幼儿可能需要增加额顶连接来维持注意力。未来的工作需要研究能提高注意力发展的早期干预措施及其对前额顶叶和注意力网络之间神经连接的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental psychobiology 生物-发育生物学

CiteScore

4.20

自引率

18.20%

发文量

125

审稿时长

6-12 weeks

期刊介绍： Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field. The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief. Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.