Developmental psychobiology最新文献

{"title":"The influence of anterior cingulate GABA+ and glutamate on emotion regulation and reactivity in adolescents and adults","authors":"Ebba Widegren,&nbsp;Matilda A. Frick,&nbsp;Johanna Motilla Hoppe,&nbsp;Jan Weis,&nbsp;Stefan Möller,&nbsp;David Fällmar,&nbsp;Johanna Mårtensson,&nbsp;Karin Brocki,&nbsp;Malin Gingnell,&nbsp;Andreas Frick","doi":"10.1002/dev.22492","DOIUrl":"https://doi.org/10.1002/dev.22492","url":null,"abstract":"<p>During adolescence, emotion regulation and reactivity are still developing and are in many ways qualitatively different from adulthood. However, the neurobiological processes underpinning these differences remain poorly understood, including the role of maturing neurotransmitter systems. We combined magnetic resonance spectroscopy in the dorsal anterior cingulate cortex (dACC) and self-reported emotion regulation and reactivity in a sample of typically developed adolescents (<i>n</i> = 37; 13–16 years) and adults (<i>n</i> = 39; 30–40 years), and found that adolescents had higher levels of glutamate to total creatine (tCr) ratio in the dACC than adults. A glutamate Í age group interaction indicated a differential relation between dACC glutamate levels and emotion regulation in adolescents and adults, and within-group follow-up analyses showed that higher levels of glutamate/tCr were related to worse emotion regulation skills in adolescents. We found no age-group differences in gamma-aminobutyric acid+macromolecules (GABA+) levels; however, emotion reactivity was positively related to GABA+/tCr in the adult group, but not in the adolescent group. The results demonstrate that there are developmental changes in the concentration of glutamate, but not GABA+, within the dACC from adolescence to adulthood, in accordance with previous findings indicating earlier maturation of the GABA-ergic than the glutamatergic system. Functionally, glutamate and GABA+ are positively related to emotion regulation and reactivity, respectively, in the mature brain. In the adolescent brain, however, glutamate is negatively related to emotion regulation, and GABA+ is not related to emotion reactivity. The findings are consistent with synaptic pruning of glutamatergic synapses from adolescence to adulthood and highlight the importance of brain maturational processes underlying age-related differences in emotion processing.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140622662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental trajectory of social reward motivation from early adolescence into adulthood in female and male Long-Evans rats","authors":"Shealin H. Murray,&nbsp;Ryanne J. Logan,&nbsp;Andrew C. Sheehan,&nbsp;Arianna R. Paolone,&nbsp;Cheryl M. McCormick","doi":"10.1002/dev.22495","DOIUrl":"https://doi.org/10.1002/dev.22495","url":null,"abstract":"<p>Most studies of adolescent and adult behavior involved one age group of each, whereas the dynamic changes in brain development suggest that there may be behavioral flux in adolescence. In two studies, we investigated developmental changes in social reward motivation in female and male Long-Evans rats from prepuberty to early adulthood in a social operant conditioning task. Given the earlier onset of puberty in females than in males, we predicted the course of social reward development would differ between the sexes. Overall, the pattern of results from both studies suggests that the trajectory of social motivation across adolescence is characterized by upward and downward shifts that do not depend on the sex of the rats. During training, in both studies, the mean number of social gate openings and percentage of social gate openings was higher at P30 (prepubertal, early adolescence) and P50 (late adolescence) than at P40 (mid adolescence) and P70 (adulthood) irrespective of sex. Nevertheless, the specific age comparisons that were significant depended on the study. In both studies, P30 rats had greater levels of social motivation than did adults in accessing a social reward when increased effort was required (progressive ratio tests). In an extinction test, only P30 and P50 rats continued to show more nose-pokes at the previously social gate than at the nonsocial gate, suggesting resistance to extinction. The results highlight the importance of characterizing behavior at several timepoints in adolescence to understand the neural mechanisms, many of which show similar discontinuities as they develop across adolescence.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140622664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal and postnatal cocaine exposure enhances the anxiety- and depression-like behaviors in rats during cocaine withdrawal","authors":"Susana Barbosa Méndez,&nbsp;Alberto Salazar-Juárez","doi":"10.1002/dev.22493","DOIUrl":"https://doi.org/10.1002/dev.22493","url":null,"abstract":"<p>Prenatal drug exposure is a public health problem, which results in profound behavioral problems during childhood and adolescence, mainly represented by an increase in the risk of cocaine abuse at an early age. In rodents, prenatal and postnatal cocaine exposure enhanced locomotor activity and cocaine- or nicotine-induced locomotor sensitization. Various authors consider that the adverse emotional states (anxiety and depression) that occur during cocaine withdrawal are the main factors that precipitate, relapse, and increase chronic cocaine abuse, which could increase the risk of relapse of cocaine abuse. Therefore, the objective of this study was to characterize anxiety- and depression-like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal in rats born to females exposed prenatally and postnatally to cocaine. A group of pregnant female Wistar rats were administered daily from day GD0 to GD21 with cocaine (cocaine preexposure group), and another group of pregnant female rats was administered daily with saline (saline preexposure group). Of the litters resulting from the cocaine-pre-exposed and saline-pre-exposed pregnant female groups, only the male rats were used for the recording of the anxiety- and depression-like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal The study found that prenatal and postnatal cocaine exposure dose-dependent enhanced anxiety- and depression-like behaviors. This suggests that prenatal and postnatal cocaine exposure can result in enhanced vulnerability to cocaine abuse in young and adult humans.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140622663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of parental technoference on toddlers: A commentary on physiological and developmental implications","authors":"Lien-Chung Wei","doi":"10.1002/dev.22489","DOIUrl":"https://doi.org/10.1002/dev.22489","url":null,"abstract":"","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140556261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium","authors":"Mónica López-Vicente,&nbsp;Eszter Szekely,&nbsp;Marie-Elyse Lafaille-Magnan,&nbsp;J. Bruce Morton,&nbsp;Tim F. Oberlander,&nbsp;Celia M. T. Greenwood,&nbsp;Ryan L. Muetzel,&nbsp;Henning Tiemeier,&nbsp;Anqi Qiu,&nbsp;Ashley Wazana,&nbsp;Tonya White","doi":"10.1002/dev.22481","DOIUrl":"10.1002/dev.22481","url":null,"abstract":"<p>This study explored the interactions among prenatal stress, child sex, and polygenic risk scores (PGS) for attention-deficit/hyperactivity disorder (ADHD) on structural developmental changes of brain regions implicated in ADHD. We used data from two population-based birth cohorts: Growing Up in Singapore Towards healthy Outcomes (GUSTO) from Singapore (<i>n</i> = 113) and Generation R from Rotterdam, the Netherlands (<i>n</i> = 433). Prenatal stress was assessed using questionnaires. We obtained latent constructs of prenatal adversity and prenatal mood problems using confirmatory factor analyses. The participants were genotyped using genome-wide single nucleotide polymorphism arrays, and ADHD PGSs were computed. Magnetic resonance imaging scans were acquired at 4.5 and 6 years (GUSTO), and at 10 and 14 years (Generation R). We estimated the age-related rate of change for brain outcomes related to ADHD and performed (1) prenatal stress by sex interaction models, (2) prenatal stress by ADHD PGS interaction models, and (3) 3-way interaction models, including prenatal stress, sex, and ADHD PGS. We observed an interaction between prenatal stress and ADHD PGS on mean cortical thickness annual rate of change in Generation R (i.e., in individuals with higher ADHD PGS, higher prenatal stress was associated with a lower rate of cortical thinning, whereas in individuals with lower ADHD PGS, higher prenatal stress was associated with a higher rate of cortical thinning). None of the other tested interactions were statistically significant. Higher prenatal stress may promote a slower brain developmental rate during adolescence in individuals with higher ADHD genetic vulnerability, whereas it may promote a faster brain developmental rate in individuals with lower ADHD genetic vulnerability.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent associations between RSA reactivity, affective and cognitive regulation, and psychopathology risk in young children exposed to varying levels of socioeconomic disadvantage","authors":"Livia Merrill,&nbsp;Rebecca Lipschutz,&nbsp;Xinge Li,&nbsp;Shutian Shen,&nbsp;Andrea Ortiz-Jimenez,&nbsp;Johanna Bick","doi":"10.1002/dev.22487","DOIUrl":"10.1002/dev.22487","url":null,"abstract":"<p>This study examined autonomic nervous system activity (respiratory sinus arrhythmia [RSA]) as a biomarker of psychopathology in an ethnically and socioeconomically diverse sample (<i>N</i> = 57) of young children ages 4–7 years. RSA was measured at baseline and across four standardized tasks designed to assess self-regulation in both affective (i.e., “hot”) and cognitive (i.e., “cool”) contexts during early childhood. Our findings reveal that age moderated RSA activity, such that reduced RSA suppression was associated with a heightened risk of externalizing problems among older children during “cool” and “hot” contexts; for younger children, only RSA suppression during “hot” contexts predicted externalizing risk. The influence of socioeconomic disadvantage did not moderate the relationship between RSA and the risk of psychopathology, and there were minimal associations between RSA suppression and internalizing symptoms at this age range. These results suggest that autonomic variability may be a more effective predictor of psychopathology risk in older children, perhaps as they transition into formal schooling and face increasingly complex cognitive and social demands. Findings have implications for the identification of psychopathology in early developmental periods when regulation over emotions becomes essential for academic and social success.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of decomposing periodic and aperiodic EEG signals for assessment of brain function in a global context","authors":"Teresa Del Bianco,&nbsp;Rianne Haartsen,&nbsp;Luke Mason,&nbsp;Virginia Carter Leno,&nbsp;Cilla Springer,&nbsp;Mandy Potter,&nbsp;Wendy Mackay,&nbsp;Petrusa Smit,&nbsp;Carlie Du Plessis,&nbsp;Lucy Brink,&nbsp;Mark H. Johnson,&nbsp;Declan Murphy,&nbsp;Eva Loth,&nbsp;Hein Odendaal,&nbsp;Emily J. H. Jones","doi":"10.1002/dev.22484","DOIUrl":"10.1002/dev.22484","url":null,"abstract":"<p>Measures of early neuro-cognitive development that are suitable for use in low-resource settings are needed to enable studies of the effects of early adversity on the developing brain in a global context. These measures should have high acquisition rates and good face and construct validity. Here, we investigated the feasibility of a naturalistic electroencephalography (EEG) paradigm in a low-resource context during childhood. Additionally, we examined the sensitivity of periodic and aperiodic EEG metrics to social and non-social stimuli. We recorded simultaneous 20-channel EEG and eye-tracking in 72 children aged 4–12 years (45 females) while they watched videos of women singing nursery rhymes and moving toys, selected to represent familiar childhood experiences. These measures were part of a feasibility study that assessed the feasibility and acceptability of a follow-up data collection of the South African Safe Passage Study, which tracks environmental adversity and brain and cognitive development from before birth up until childhood. We examined whether data quantity and quality varied with child characteristics and the sensitivity of varying EEG metrics (canonical band power in the theta and alpha band and periodic and aperiodic features of the power spectra). We found that children who completed the EEG and eye-tracking assessment were, in general, representative of the full cohort. Data quantity was higher in children with greater visual attention to the stimuli. Out of the tested EEG metrics, periodic measures in the theta frequency range were most sensitive to condition differences, compared to alpha range measures and canonical and aperiodic EEG measures. Our results show that measuring EEG during ecologically valid social and non-social stimuli is feasible in low-resource settings, is feasible for most children, and produces robust indices of social brain function. This work provides preliminary support for testing longitudinal links between social brain function, environmental factors, and emerging behaviors.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dog's life: Early life histories influence methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes, cortisol levels, and attachment styles","authors":"Samantha L. Awalt,&nbsp;Lidia Boghean,&nbsp;David Klinkebiel,&nbsp;Rosemary Strasser","doi":"10.1002/dev.22482","DOIUrl":"10.1002/dev.22482","url":null,"abstract":"<p>Early life deprivation and stress can contribute to life-long, problematic consequences, including epigenetic variations related to behavior and health. Domestic dogs share human environments and social–cognitive traits, making them a promising comparative model to examine developmental plasticity. We examined 47 owner–dog dyads, including dogs rescued from abusive or neglectful environments, and matched control dogs for changes in DNA methylation of glucocorticoid (<i>NR3C1</i>) and oxytocin (<i>OXTR</i>) receptor genes previously shown to be affected by early life stress in other species including humans. We used an attachment paradigm, which included a separation event to examine cortisol levels and owner–dog attachment styles. Overall, dogs with adverse histories had different <i>NR3C1</i> methylation patterns as a function of age and less <i>OXTR</i> methylation than comparison dogs. Dogs with adverse histories did not differ in their cortisol change from baseline to poststressor from comparison dogs, but the change in cortisol was associated with <i>NR3C1</i> methylation. In addition, dogs with a history of early life stress had more insecure attachment styles; for every unit increase of <i>OXTR</i> methylation, the odds increased for insecure attachment style. This study demonstrates that adverse life histories lead to methylation differences, resulting in the hypothalamic–pituitary–adrenal (HPA) axis's dysregulation and differences in behavioral phenotypes.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dev.22482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions among stress, behavioral inhibition, and delta–beta coupling predict adolescent anxiety during the COVID-19 pandemic","authors":"Michelle L. Ramos,&nbsp;Anna M. Zhou,&nbsp;Marisa N. Lytle,&nbsp;Sarah Myruski,&nbsp;Koraly Pérez-Edgar,&nbsp;Kristin A. Buss","doi":"10.1002/dev.22485","DOIUrl":"10.1002/dev.22485","url":null,"abstract":"<p>The COVID-19 pandemic brought about unprecedented changes and uncertainty to the daily lives of youth. The range of adjustment in light of a near-universal experience of COVID restrictions highlights the importance of identifying factors that may render some individuals more susceptible to heightened levels of anxiety during stressful life events than others. Two risk factors to consider are temperamental behavioral inhibition (BI) and difficulties in emotion regulation (ER). As such, the current paper focused on BI examined prior to COVID, because of its developmental link to anxiety and ER, as difficulties may be associated with differences in anxiety. We examined a neurocognitive marker of ER processes, delta–beta coupling (DBC). The current paper had two goals: (1) to examine BI in relation to COVID-related worry and social anxiety experienced during the pandemic, and (2) to explore the role of individual differences in early DBC in the relationship between BI and anxiety outcomes 6 months apart during COVID-19 (<i>n </i>= 86; T1 <i>M</i>_age = 15.95, <i>SD </i>= 1.73; T6 <i>M</i>_age = 16.43, <i>SD </i>= 1.73). We found support for the moderating role of DBC in the relationship between BI levels and social anxiety disorder (SAD) symptom severity during the pandemic. Here, high BI was predictive of increased SAD symptom levels in adolescents with stronger DBC.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting respiratory sinus arrhythmia moderates the within-person relations of parental emotional expressivity and children's prosocial behaviors","authors":"Runzhu Zhang,&nbsp;Zhenhong Wang","doi":"10.1002/dev.22483","DOIUrl":"10.1002/dev.22483","url":null,"abstract":"<p>Parental supportive emotional expressivity could contribute to children's prosocial behaviors, and such an effect may differ for children with different levels of resting respiratory sinus arrhythmia (RSA). This study disentangled the stable differences across dyads (i.e., between-person effects) from the dynamic associations between parental expressivity and children's prosocial behaviors within dyads (i.e., within-person effects) and determined how resting RSA functioned as a susceptibility factor in such effects. The longitudinal design consisted of three measurements with a 1-year interval performed among 208 school-aged children (48.6% girls; Han nationality) and their parents (153 mothers and 55 fathers). The initial measurement was conducted when the children were 7 years old (<i>M</i>_age = 7.13, <i>SD</i>_age = .33). Resting RSA was calculated at the first measurement; parents reported children's prosocial behaviors and parental expressivity at each of the three measurements. The results demonstrated significant between- and within-person effects of parental expressivity on children's prosocial behaviors and found a moderating role of children's resting RSA in the within-person effects. These findings suggest that children displayed more prosocial behaviors when parents showed more supportive expressivity both across and within dyads, and higher resting RSA operated as a differential susceptibility factor in the intraindividual fluctuations in parental expressivity.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}