Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline
{"title":"作为雄激素暴露分析物的胎粪：通过不同的母胎生物标志物进行分析","authors":"Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline","doi":"10.1002/dev.22550","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Meconium, the first stool produced by neonates, has been used as an analyte for exogenous fetal exposures. However, few studies have investigated the relationship between meconium and androgen exposure in utero. Here, we examine the associations of testosterone and dehydroepiandrosterone (DHEA) across maternal antenatal salivary testosterone, cord blood, meconium, and infant salivary testosterone. A total of 47 women with singleton, uncomplicated pregnancies, and their infants were included in this study. Participants were recruited from an academic obstetric clinic. Maternal saliva was collected at 36-weeks’ gestation. Cord blood and meconium were collected at birth. Infant salivary testosterone was collected at 1 and 4 weeks of age. Multivariate model results showed that meconium testosterone was associated with neonatal testosterone at 1 (<i>F </i>= 5.62, <i>p </i>= 0.029) and 4 weeks (<i>F </i>= 4.28, <i>p </i>= 0.048) postnatal age; no sex differences were detected. This study suggests meconium is a valuable tool for evaluating endogenous androgen exposure and should be used in future studies to investigate the fetal hormonal milieu.</p>\n </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 7","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Meconium as an Analyte for Androgen Exposure: Analysis Through Varying Maternal-Fetal Biomarkers\",\"authors\":\"Nicole Knudsen, Stacey Tang, Sylvie Lauzon, Supriya Dhaurali, Nathaniel W. Snyder, Kristin M. Voegtline\",\"doi\":\"10.1002/dev.22550\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Meconium, the first stool produced by neonates, has been used as an analyte for exogenous fetal exposures. However, few studies have investigated the relationship between meconium and androgen exposure in utero. Here, we examine the associations of testosterone and dehydroepiandrosterone (DHEA) across maternal antenatal salivary testosterone, cord blood, meconium, and infant salivary testosterone. A total of 47 women with singleton, uncomplicated pregnancies, and their infants were included in this study. Participants were recruited from an academic obstetric clinic. Maternal saliva was collected at 36-weeks’ gestation. Cord blood and meconium were collected at birth. Infant salivary testosterone was collected at 1 and 4 weeks of age. Multivariate model results showed that meconium testosterone was associated with neonatal testosterone at 1 (<i>F </i>= 5.62, <i>p </i>= 0.029) and 4 weeks (<i>F </i>= 4.28, <i>p </i>= 0.048) postnatal age; no sex differences were detected. This study suggests meconium is a valuable tool for evaluating endogenous androgen exposure and should be used in future studies to investigate the fetal hormonal milieu.</p>\\n </div>\",\"PeriodicalId\":11086,\"journal\":{\"name\":\"Developmental psychobiology\",\"volume\":\"66 7\",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Developmental psychobiology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/dev.22550\",\"RegionNum\":4,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental psychobiology","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dev.22550","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Meconium as an Analyte for Androgen Exposure: Analysis Through Varying Maternal-Fetal Biomarkers
Meconium, the first stool produced by neonates, has been used as an analyte for exogenous fetal exposures. However, few studies have investigated the relationship between meconium and androgen exposure in utero. Here, we examine the associations of testosterone and dehydroepiandrosterone (DHEA) across maternal antenatal salivary testosterone, cord blood, meconium, and infant salivary testosterone. A total of 47 women with singleton, uncomplicated pregnancies, and their infants were included in this study. Participants were recruited from an academic obstetric clinic. Maternal saliva was collected at 36-weeks’ gestation. Cord blood and meconium were collected at birth. Infant salivary testosterone was collected at 1 and 4 weeks of age. Multivariate model results showed that meconium testosterone was associated with neonatal testosterone at 1 (F = 5.62, p = 0.029) and 4 weeks (F = 4.28, p = 0.048) postnatal age; no sex differences were detected. This study suggests meconium is a valuable tool for evaluating endogenous androgen exposure and should be used in future studies to investigate the fetal hormonal milieu.
期刊介绍：
Developmental Psychobiology is a peer-reviewed journal that publishes original research papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavior development. Research that focuses on development in the embryo/fetus, neonate, juvenile, or adult animal and multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, or evolution is appropriate. The journal represents a broad phylogenetic perspective on behavior development by publishing studies of invertebrates, fish, birds, humans, and other animals. The journal publishes experimental and descriptive studies whether carried out in the laboratory or field.
The journal also publishes review articles and theoretical papers that make important conceptual contributions. Special dedicated issues of Developmental Psychobiology , consisting of invited papers on a topic of general interest, may be arranged with the Editor-in-Chief.
Developmental Psychobiology also publishes Letters to the Editor, which discuss issues of general interest or material published in the journal. Letters discussing published material may correct errors, provide clarification, or offer a different point of view. Authors should consult the editors on the preparation of these contributions.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
