Developmental psychobiology最新文献

{"title":"Developmental Trajectory of Autistic-Like Behaviors in a Prenatal Valproic Acid Rat Model of Autism","authors":"Bin Lian,&nbsp;Yihan He,&nbsp;Da Dong,&nbsp;Li Quan,&nbsp;Tingyong Feng,&nbsp;Ming Li","doi":"10.1002/dev.70008","DOIUrl":"10.1002/dev.70008","url":null,"abstract":"<div>\u0000 \u0000 <p>Autism spectrum disorders (ASDs) are characterized by deficits in social functioning, stereotyped patterns of behaviors, narrowed interests, and elevated anxiety. Certain ASD symptoms can persist, whereas others may improve throughout the lifespan, but the specific patterns of changes have not been clearly delineated. Using a valproic acid (VPA) rat model of ASD, the present study took a developmental approach and examined how autistic-like behaviors, including anxiety-like behavior, object obsession, and social functioning deficits, manifested differently in three critical periods representing preadolescent (postnatal day [PND] 25), adolescent (PND 45), and adulthood life stage (PND 75) in a sex-dependent manner. Starting on PNDs 25, 45, and 75, VPA- or saline-exposed male and female offspring were tested in an elevated plus maze (EPM) and a newly validated composite social and object interaction and a triple recognition test (object, spatial, and social recognition). Across the three age groups, VPA-exposed offspring did not exhibit enhanced anxiety-like behavior in the EPM nor enhanced object interaction (“object obsession”) in the triple recognition test. However, both male and female preadolescent (PND 25) VPA-exposed offspring showed a significantly increased latency to initiate social contact than the saline-exposed controls, although their latencies to contact novel objects were comparable to those of the controls. Male preadolescent and adolescent VPA-exposed offspring, to a lesser extent the female preadolescent offspring, exhibited significantly lower levels of social interaction. These social functioning deficits were absent in adult VPA offspring. Additionally, prenatal VPA exposure did not cause an impairment of object recognition, spatial recognition, or social recognition of a familiar conspecific. Unexpectedly, it enhanced social recognition of a novel conspecific, but only in adolescent female offspring. These findings suggest that this rat model based on prenatal VPA exposure is valid in capturing early social motivational and functioning deficits but is limited in its capacity to model increased object obsession and enhanced anxiety as seen in ASD, as well as the developmental trajectory of non-social ASD symptoms. Recognizing these limitations is important as it informs us how to properly use this model to investigate the neurobiology of ASD and incentivizes us to develop better rodent models.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warm Parenting Throughout Adolescence Predicts Basal Parasympathetic Activity Among Mexican-Origin Youths","authors":"Helena Her,&nbsp;Elisa Ugarte,&nbsp;David G. Weissman,&nbsp;Richard W. Robins,&nbsp;Amanda E. Guyer,&nbsp;Paul D. Hastings","doi":"10.1002/dev.70012","DOIUrl":"10.1002/dev.70012","url":null,"abstract":"<p>Parenting that is warm and supportive has been consistently linked to better emotion regulation in children, but less is known about this association in adolescents. Adolescence is thought to be an important period for emotion regulation development given that it coincides with the emergence of mental health issues. Respiratory sinus arrhythmia (RSA) is a measure of parasympathetic regulation linked to emotion and behavior regulation. Despite the well-documented links between parenting practices and emotion regulation, and between RSA and emotion regulation, few studies have focused on the association between positive parenting and adolescent RSA or included both mothers and fathers. The current study analyzed the influence of warm parenting throughout adolescence (ages 10–16) on basal RSA at age 17 in 229 Mexican-origin youths. Latent-growth curve models were used to analyze associations between maternal and paternal warmth and baseline RSA. Changes in maternal, but not paternal, warmth from age 10 to 16 were related to youths’ basal RSA at age 17. Specifically, youths who perceived increasing (or less decreasing) maternal warmth across adolescence had higher basal RSA. This finding suggests that positive maternal parenting experiences during adolescence “get under the skin” to enhance parasympathetic functioning that supports youths’ emotion regulation capacities.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Out of Sight, Out of Mind? Neuronal Gamma Oscillations During Occlusion Events in Infants","authors":"Regine Slinning,&nbsp;Seth B. Agyei,&nbsp;Silje Hognestad Kristoffersen,&nbsp;F. R. (Ruud) van der Weel,&nbsp;Audrey L. H. van der Meer","doi":"10.1002/dev.70006","DOIUrl":"10.1002/dev.70006","url":null,"abstract":"<p>Object permanence allows infants to interact successfully with objects in the environment. What happens in the human infant brain when objects move in and out of sight? This study used high-density electroencephalography (hdEEG) to record induced oscillatory brain activities in 29 locomotor infants before, during, and after occlusion of a moving object traveling at different speeds. Temporal spectral evolution (TSE) showed that before and after the occlusion event, event-related synchronized (ERS) brain activity was observed, whereas event-related desynchronized (ERD) activity was detected when the car was hidden behind the occluder. Both synchronized and desynchronized brain activities were found in the gamma frequency band (&gt;30 Hz) in visual areas. Coherence connectivity analysis showed significant cluster differences before and during occlusion, during and after occlusion, and before and after occlusion in the gamma (30–150 Hz) and theta range (4–7 Hz) in several brain sources of interest. It was concluded that locomotor infants between 8.5 and 12 months of age show high-frequency brain oscillations while perceiving a moving object going temporarily out of sight. The significant cluster differences indicate the beginning of specialized connectivity networks, where object permanence is processed within dedicated visual, parietal, and central areas along the dorsal processing stream.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Strength of Auditory Maturity Across Different Levels of Language Ability: An Exploratory Quantile Regression Study","authors":"Theresa Pham,&nbsp;Alyssa Janes,&nbsp;Elaine Kwok,&nbsp;Janis Oram","doi":"10.1002/dev.70013","DOIUrl":"10.1002/dev.70013","url":null,"abstract":"<p>Auditory evoked potential-age (AEP-age) is proposed to index auditory maturation and has been found to predict language skills in children with and without a language disorder. However, reporting average effects using linear regression does not fully capitalize on the potential of AEP-age to estimate individual differences in young children. This study used a quantile regression approach to examine the predictive utility of AEP-age for 105 typical <i>and</i> neurodiverse 7–10-year-old children (61 males; 44 females; largely monolingual English) with varying language skills without creating subgroups. Although linear regression did not find an association between AEP-age and language skills, the quantile model added specificity by revealing differential associations. AEP-age was only related to language skills for children at around the median point of the language continuum, but, not for those at the lowest or highest end of the language distribution. Overall, the quantile regression methodology provides us with the flexibility of understanding how AEP-age is related to different language abilities.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Correlates of Emotion Regulation and Associations With Disordered Eating During Preadolescence","authors":"Kai S. Thomas,&nbsp;Catherine R. G. Jones,&nbsp;Marc O. Williams,&nbsp;Ross E. Vanderwert","doi":"10.1002/dev.70009","DOIUrl":"10.1002/dev.70009","url":null,"abstract":"<p>Difficulties with emotion regulation have been documented in individuals with eating and internalizing disorders. However, there is limited research examining the cognitive processes underlying these difficulties. Using a dimensional approach, the current study examined the link between the behavioral and neural correlates of response inhibition, disordered eating, and internalizing symptoms in a community sample of preadolescents. A total of 50 children (<i>M</i> age = 10.9 years; 58% male) completed an emotion Go/No-Go task, while ERP components were recorded, as well as self-report measures of disordered eating and internalizing symptoms. In addition, children completed an emotion recognition task to establish whether there were fundamental differences in emotion recognition across high and low levels of disordered eating and internalizing symptoms. Increased disordered eating was associated with increased mean P3-NoGo amplitudes when inhibiting responses to happy facial expressions, as well as poorer recognition of happy faces. These associations were not found for internalizing symptoms. Our findings suggest an early disruption in response inhibition, specifically for happy emotional expressions, may be relevant to the development of disordered eating behaviors in preadolescence.</p>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of Maternal Behavior, Infant's Respiratory Sinus Arrhythmia, and Emotional Recovery Following the Still Face Paradigm","authors":"Lindsey M. Green,&nbsp;Stephanie F. Thompson,&nbsp;Lisa Shimomaeda,&nbsp;Lynn Fainsilber Katz,&nbsp;Liliana J. Lengua","doi":"10.1002/dev.70011","DOIUrl":"10.1002/dev.70011","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of emotion regulation is integral to children's socioemotional adjustment. Respiratory sinus arrhythmia (RSA) reflects parasympathetic regulation of cardiac arousal and is thought to be an indicator of emotion regulation. However, it is unclear how RSA is associated with positive maternal behaviors and infant emotional recovery in real time over the course of a recovery period following a social stressor. Mothers and their 5- to 6-month-old infants (<i>N</i> = 143) completed the Still Face paradigm. Using a series of autoregressive latent trajectory models, the current study aimed to elucidate the associations among observed maternal warmth, infant RSA, and observed infant negative affect across a 5-min observation. The hypotheses were that trajectories of maternal warmth would predict trajectories of infant RSA and negative affect, and that trajectories of RSA would be associated with the infants' observed negative affect. Change in maternal warmth was associated with infant negative affect and RSA at the end of the reunion and change in RSA was associated with ultimate levels of negative affect. The results provide partial support for our hypothesis that maternal warmth supports infant physiological, and in turn, emotional recovery.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Sensitization in Virgin Female Rats: Behavioral Effects of Enriched Environment","authors":"Mauricio A. Núñez-Murrieta,&nbsp;Esmeralda Rendón-Candanedo,&nbsp;Diana Angeles-Torres,&nbsp;Paula Noguez,&nbsp;Genaro A. Coria-Avila,&nbsp;Victoria E. Bolado-García,&nbsp;Aleph A. Corona-Morales","doi":"10.1002/dev.70010","DOIUrl":"10.1002/dev.70010","url":null,"abstract":"<div>\u0000 \u0000 <p>In virgin female rats, the continuous presence of pups causes them to express typical maternal behaviors, a process known as maternal sensitization. Previous experience with pups accelerates maternal sensitization. It is also known that in primiparous rats, enriched environment (EE) increases the expression of maternal behaviors. Here, we investigated whether experience, other than pup exposure, affects the process of maternal sensitization and hypothesized that EE increases the expression of maternal behaviors and maternal motivation in virgin rats. Virgin adult females were housed in standard conditions or physical and social EE for 21 days. Then, females were exposed daily to pups until they expressed full maternal behaviors. Thereafter, females performed pup preference, pup motivation in a novel context, and resident-intruder tests. We found that initial pup rejection was higher in EE rats, but eventually, both groups became maternally sensitized simultaneously. The frequency and duration of pup licking were higher in EE rats. In the other tests, EE rats exhibited more entries to the open arms, retrieved more pups toward the closed arms, and were more aggressive towards an intruder. We conclude that housing in a social EE modulates aspects of the pup-induced maternal sensitization, particularly increasing pup licking and motivation in both familiar and novel circumstances.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Effects of Prenatal Buprenorphine and Methadone on Postnatal Growth and Gene Expression in the Nucleus Accumbens","authors":"Kelsea R. Gildawie,&nbsp;Kerri E. Budge,&nbsp;Fair M. Vassoler,&nbsp;Elizabeth Yen,&nbsp;Elizabeth M. Byrnes","doi":"10.1002/dev.70015","DOIUrl":"10.1002/dev.70015","url":null,"abstract":"<div>\u0000 \u0000 <p>Methadone and buprenorphine are commonly prescribed during pregnancy to maintain recovery and prevent symptoms of withdrawal in women with opioid use disorder. Infants prenatally exposed to medications for opioid use disorder (MOUD), however, commonly show signs of neonatal opioid withdrawal syndrome (NOWS), which can include feeding-related issues like hyperphagia. To investigate the effects of prenatal MOUD exposure on feeding behavior, female Sprague-Dawley rats were implanted with osmotic minipumps filled with methadone, buprenorphine, or saline and subsequently mated. On postnatal day (PND) 1, buprenorphine- and methadone-exposed offspring weighed less than saline-exposed subjects. Throughout early postnatal development (PND2, 7, and 12), this reduction in weight persisted in buprenorphine, but not methadone, offspring. RNAscope in situ hybridization was then used to measure expression of genes in the nucleus accumbens (NAc) previously associated with hyperphagia in NOWS infants, including proopiomelanocortin (<i>Pomc</i>), neuropeptide Y2 receptors (<i>Npy2r</i>), and dopamine type 2 receptors (<i>Drd2</i>). Distinct developmental expression patterns were noted across the postnatal period, with few effects of MOUD; however, significantly lower <i>Pomc</i> expression was observed in methadone-exposed but not buprenorphine-exposed offspring. These findings demonstrate differential effects of methadone and buprenorphine on offspring development and gene expression, highlighting differences in offspring outcomes associated with these two MOUDs.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Prenatal Stress and the Offspring Gut Microbiome: A Cross-Species Systematic Review","authors":"Michelle D. Graf,&nbsp;Nicolas Murgueitio,&nbsp;Sarah C. Vogel,&nbsp;Lauren Hicks,&nbsp;Alexander L. Carlson,&nbsp;Cathi B. Propper,&nbsp;Mary Kimmel","doi":"10.1002/dev.70005","DOIUrl":"10.1002/dev.70005","url":null,"abstract":"<div>\u0000 \u0000 <p>The prenatal period is a critical developmental juncture with enduring effects on offspring health trajectories. An individual's gut microbiome is associated with health and developmental outcomes across the lifespan. Prenatal stress can disrupt an infant's microbiome, thereby increasing susceptibility to adverse outcomes. This cross-species systematic review investigates whether maternal prenatal stress affects the offspring's gut microbiome. The study analyzes 19 empirical, peer-reviewed research articles, including humans, rodents, and non-human primates, that included prenatal stress as a primary independent variable and offspring gut microbiome characteristics as an outcome variable. Prenatal stress appeared to correlate with differences in beta diversity and specific microbial taxa, but not alpha diversity. Prenatal stress is positively correlated with Proteobacteria, Bacteroidaceae, Lachnospiraceae, Prevotellaceae, <i>Bacteroides</i>, and <i>Serratia</i>. Negative correlations were observed for Actinobacteria, Enterobacteriaceae, Streptococcaceae, <i>Bifidobacteria, Eggerthella, Parabacteroides</i>, and <i>Streptococcus</i>. Evidence for the direction of association between prenatal stress and <i>Lactobacillus</i> was mixed. The synthesis of findings was limited by differences in study design, operationalization and timing of prenatal stress, timing of infant microbiome sampling, and microbiome analysis methods.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"67 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Prenatal, Perinatal, and Postnatal Factors and ADHD: The Role of Nutrition, Diet, and Stress","authors":"Lubna Al-Gailani,&nbsp;Ali Al-Kaleel","doi":"10.1002/dev.70004","DOIUrl":"10.1002/dev.70004","url":null,"abstract":"<div>\u0000 \u0000 <p>Attention-Deficit Hyperactive Disorder (ADHD) is a neurobehavioral syndrome affecting children aged 6–17 with symptoms manifesting before age 12. ADHD presents heterogeneously and is associated with various psychiatric disorders. The cause remains elusive, but genetic and environmental factors, brain region maturation delays, and neurotransmitter dysregulation are implicated. Effective treatment requires a multi-disciplinary approach, primarily involving pharmacological and behavioral intervention. Stimulants like methylphenidate and amphetamines are first-line medications, but non-stimulants may be considered for some patients. However, stimulants face challenges related to misuse, dependence, and long-term tolerability issues. The etiology of ADHD involved genetic predisposition, environmental influences, and prenatal, perinatal, and postnatal factors. Prenatal causes encompass maternal diet, alcohol consumption, viral infections, and stress. Postnatal factors include head trauma, meningitis, toxin, nutritional deficiencies, as well as iodine deficiency and hypothyroidism. The gut microbiome's role in ADHD is emerging, influencing neurodevelopment through microbiota–gut–brain axis. Understanding these diverse etiological factors is essential for comprehensive ADHD management.</p>\u0000 </div>","PeriodicalId":11086,"journal":{"name":"Developmental psychobiology","volume":"66 8","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}